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Conserved domains on  [gi|9910544|ref|NP_064624|]
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CDC42 small effector protein 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CRIB super family cl00113
PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; ...
 29-67 2.23e-03

PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the Ras-Rac pathway. CRIB-containing effector proteins are functionally diverse and include serine/threonine kinases, tyrosine kinases, actin-binding proteins, and adapter molecules.


The actual alignment was detected with superfamily member cd00132:

Pssm-ID: 412170  Cd Length: 42  Bit Score: 32.41  E-value: 2.23e-03
                       10        20        30
               ....*....|....*....|....*....|....*....
gi 9910544  29 MIGEPMNFVHLTHIGSGEMGaGDGLAMTGAVQEQMRSKG 67
Cdd:cd00132  2 EISTPTDFKHISHVGWDGVG-FDGANLPPDLQSLFQTAG 39
 
Name Accession Description Interval E-value
CRIB cd00132
PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; ...
 29-67 2.23e-03

PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the Ras-Rac pathway. CRIB-containing effector proteins are functionally diverse and include serine/threonine kinases, tyrosine kinases, actin-binding proteins, and adapter molecules.


Pssm-ID: 238077  Cd Length: 42  Bit Score: 32.41  E-value: 2.23e-03
                       10        20        30
               ....*....|....*....|....*....|....*....
gi 9910544  29 MIGEPMNFVHLTHIGSGEMGaGDGLAMTGAVQEQMRSKG 67
Cdd:cd00132  2 EISTPTDFKHISHVGWDGVG-FDGANLPPDLQSLFQTAG 39
PBD pfam00786
P21-Rho-binding domain; Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also ...
 29-43 9.65e-03

P21-Rho-binding domain; Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also known as the Cdc42/Rac interactive binding (CRIB).


Pssm-ID: 395634  Cd Length: 59  Bit Score: 31.13  E-value: 9.65e-03
                         10
                 ....*....|....*
gi 9910544    29 MIGEPMNFVHLTHIG 43
Cdd:pfam00786  1 MISAPTNFKHTVHVG 15
 
Name Accession Description Interval E-value
CRIB cd00132
PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; ...
 29-67 2.23e-03

PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the Ras-Rac pathway. CRIB-containing effector proteins are functionally diverse and include serine/threonine kinases, tyrosine kinases, actin-binding proteins, and adapter molecules.


Pssm-ID: 238077  Cd Length: 42  Bit Score: 32.41  E-value: 2.23e-03
                       10        20        30
               ....*....|....*....|....*....|....*....
gi 9910544  29 MIGEPMNFVHLTHIGSGEMGaGDGLAMTGAVQEQMRSKG 67
Cdd:cd00132  2 EISTPTDFKHISHVGWDGVG-FDGANLPPDLQSLFQTAG 39
PBD pfam00786
P21-Rho-binding domain; Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also ...
 29-43 9.65e-03

P21-Rho-binding domain; Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also known as the Cdc42/Rac interactive binding (CRIB).


Pssm-ID: 395634  Cd Length: 59  Bit Score: 31.13  E-value: 9.65e-03
                         10
                 ....*....|....*
gi 9910544    29 MIGEPMNFVHLTHIG 43
Cdd:pfam00786  1 MISAPTNFKHTVHVG 15
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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