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Conserved domains on  [gi|158711686|ref|NP_065066|]
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solute carrier family 12 member 5 isoform 3 [Mus musculus]

Protein Classification

solute carrier family 12 protein( domain architecture ID 11489985)

solute carrier family 12 protein similar to Arabidopsis thaliana cation-chloride cotransporter 1, which mediates both potassium-chloride and sodium-chloride cotransports and is involved in plant development and Cl(-) homeostasis, or human kidney-specific Na-K-Cl symporter that mediates the transepithelial NaCl reabsorption in the thick ascending limb and plays an essential role in the urinary concentration and volume regulation

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
21-1115 0e+00

K-Cl cotransporter; [Transport and binding proteins, Other]


:

Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 1342.06  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686    21 NPKESSPFINSTDTEKGREYDGRNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSREHEEAENNEGGKKKPV-QAPRMGT 99
Cdd:TIGR00930    1 NTVDAVPRIEHYRNSEGQGGPKRNRPSLEELHDLLDKVVSLLGPLADYTNNGQGMKEHEEAEDAEGTKEKPPaGAVKFGW 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   100 FMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGA 179
Cdd:TIGR00930   81 VMGVLVPCLLNIWGVILFLRLSWIVGQAGIGLSLLIILLCCCVTTITGLSMSAIATNGVVKGGGAYYLISRSLGPEFGGS 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   180 VGLCFYLGTTFAGAMYILGTIEILLAylfpamaIFKaEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVF 259
Cdd:TIGR00930  161 IGLIFAFANAVAVAMYVVGFAETVLD-------LLR-ENGSKIMVDPINDIRIYGTVTVVVLLGISFAGMEWENKAQVLF 232
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   260 LGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHgfdvcaklawegnetvttrlwglfcssrllnatcdeyftrnn 339
Cdd:TIGR00930  233 LVIVLLSILNIFVGTIIPAFDKPAKGFFGLGNEIFSEN------------------------------------------ 270
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   340 vtEIQGIPGAASGlikenlwssyltkgviverrgmpsvgladgtpvdmdhpyvfsdmtsyFTLLVGIYFPSVTGIMAGSN 419
Cdd:TIGR00930  271 --FIPGIPGPEGG-----------------------------------------------FFSLFGIFFPSVTGILAGAN 301
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   420 RSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVN---------------------GNLVVGT 478
Cdd:TIGR00930  302 ISGDLKDPQKAIPKGTLLAILTTTVVYLGSVVLFGACVVRDATGDKNDTLVTnctsaacfsecahntcsyglmNNLQVMS 381
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   479 LAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKA-NGEPTWALLLTACICEIGILIASLDEV 557
Cdd:TIGR00930  382 LVSPFPPLITAGIFSATLSSALASLVSAPRLFQALCKDNIYPFLQFFGKGYGkNGEPLRAYLLTAFIAEGFILIAELNTI 461
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   558 APILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGA 637
Cdd:TIGR00930  462 APIISNFFLASYALINFSCFHASLLRSPGWRPRFKYYHWWLSLLGASLCCAIMFLISWWAALVAMVIALFLYKYVTYKKP 541
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   638 EKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDqdqnVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLD 717
Cdd:TIGR00930  542 DVNWGSSTQALSYSLALYSLLRLEEVEDHVKNWRPQCLVLTGPP----VCRPALLDFASQFTKGKGLMICGSVIQGPRLE 617
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   718 NHPQAQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQkEDHQTWRNFIELVRE 797
Cdd:TIGR00930  618 CVKEAQAAEAKIQTWLEKNKVKAFYAVVVADDLREGVRHLIQASGLGRMKPNTLVMGYKKDWRQ-AEPRAWETYIGIIHD 696
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   798 TTAGHLALLVTKNVSMFPGNP--------------------------------------ERFSEGSIDVWWIVHDGGMLM 839
Cdd:TIGR00930  697 AFDAHLAVVVVRNSEGLPISVlqvqeelendcsedsielndgkistqpdmhleastqfqKKQGKGTIDVWWLVDDGGLTL 776
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   840 LLPFLLRHHKVWRKCKMRIFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMhesDISAytYEKTLVMEQRSQILKQM 919
Cdd:TIGR00930  777 LLPYLLTTKKVWKKCKIRIFVGAQKDDRSEQEKKDMATLLYKFRIDAEVIVVLM---DINA--KPQTESMEAFEEMIRPF 851
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   920 HLTKNEREREIqsitdesrgsirrknpanprlrlnvpeetacdneekpeeevqlihdqsapscpssspspgeepegeret 999
Cdd:TIGR00930  852 RLHKTEKDREA--------------------------------------------------------------------- 862
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686  1000 dPEVHLTWTKDKSVAEKNkgpspvssegikdffsmkpewenlNQSNVRRMHTAVRLNEVIVNKSRDAKLVLLNMPGPPRN 1079
Cdd:TIGR00930  863 -KDPKMTWTKPWKITDAE------------------------LQSNVRKSYRQVRLNELLLEYSRDAALVVLSLPVPRKG 917
                         1130      1140      1150
                   ....*....|....*....|....*....|....*.
gi 158711686  1080 RNGDENYMEFLEVLTEQLDRVMLVRGGGREVITIYS 1115
Cdd:TIGR00930  918 SIPDELYMAWLEVLSEDLPPVLLVRGNHRNVLTFYS 953
 
Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
21-1115 0e+00

K-Cl cotransporter; [Transport and binding proteins, Other]


Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 1342.06  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686    21 NPKESSPFINSTDTEKGREYDGRNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSREHEEAENNEGGKKKPV-QAPRMGT 99
Cdd:TIGR00930    1 NTVDAVPRIEHYRNSEGQGGPKRNRPSLEELHDLLDKVVSLLGPLADYTNNGQGMKEHEEAEDAEGTKEKPPaGAVKFGW 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   100 FMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGA 179
Cdd:TIGR00930   81 VMGVLVPCLLNIWGVILFLRLSWIVGQAGIGLSLLIILLCCCVTTITGLSMSAIATNGVVKGGGAYYLISRSLGPEFGGS 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   180 VGLCFYLGTTFAGAMYILGTIEILLAylfpamaIFKaEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVF 259
Cdd:TIGR00930  161 IGLIFAFANAVAVAMYVVGFAETVLD-------LLR-ENGSKIMVDPINDIRIYGTVTVVVLLGISFAGMEWENKAQVLF 232
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   260 LGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHgfdvcaklawegnetvttrlwglfcssrllnatcdeyftrnn 339
Cdd:TIGR00930  233 LVIVLLSILNIFVGTIIPAFDKPAKGFFGLGNEIFSEN------------------------------------------ 270
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   340 vtEIQGIPGAASGlikenlwssyltkgviverrgmpsvgladgtpvdmdhpyvfsdmtsyFTLLVGIYFPSVTGIMAGSN 419
Cdd:TIGR00930  271 --FIPGIPGPEGG-----------------------------------------------FFSLFGIFFPSVTGILAGAN 301
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   420 RSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVN---------------------GNLVVGT 478
Cdd:TIGR00930  302 ISGDLKDPQKAIPKGTLLAILTTTVVYLGSVVLFGACVVRDATGDKNDTLVTnctsaacfsecahntcsyglmNNLQVMS 381
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   479 LAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKA-NGEPTWALLLTACICEIGILIASLDEV 557
Cdd:TIGR00930  382 LVSPFPPLITAGIFSATLSSALASLVSAPRLFQALCKDNIYPFLQFFGKGYGkNGEPLRAYLLTAFIAEGFILIAELNTI 461
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   558 APILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGA 637
Cdd:TIGR00930  462 APIISNFFLASYALINFSCFHASLLRSPGWRPRFKYYHWWLSLLGASLCCAIMFLISWWAALVAMVIALFLYKYVTYKKP 541
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   638 EKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDqdqnVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLD 717
Cdd:TIGR00930  542 DVNWGSSTQALSYSLALYSLLRLEEVEDHVKNWRPQCLVLTGPP----VCRPALLDFASQFTKGKGLMICGSVIQGPRLE 617
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   718 NHPQAQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQkEDHQTWRNFIELVRE 797
Cdd:TIGR00930  618 CVKEAQAAEAKIQTWLEKNKVKAFYAVVVADDLREGVRHLIQASGLGRMKPNTLVMGYKKDWRQ-AEPRAWETYIGIIHD 696
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   798 TTAGHLALLVTKNVSMFPGNP--------------------------------------ERFSEGSIDVWWIVHDGGMLM 839
Cdd:TIGR00930  697 AFDAHLAVVVVRNSEGLPISVlqvqeelendcsedsielndgkistqpdmhleastqfqKKQGKGTIDVWWLVDDGGLTL 776
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   840 LLPFLLRHHKVWRKCKMRIFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMhesDISAytYEKTLVMEQRSQILKQM 919
Cdd:TIGR00930  777 LLPYLLTTKKVWKKCKIRIFVGAQKDDRSEQEKKDMATLLYKFRIDAEVIVVLM---DINA--KPQTESMEAFEEMIRPF 851
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   920 HLTKNEREREIqsitdesrgsirrknpanprlrlnvpeetacdneekpeeevqlihdqsapscpssspspgeepegeret 999
Cdd:TIGR00930  852 RLHKTEKDREA--------------------------------------------------------------------- 862
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686  1000 dPEVHLTWTKDKSVAEKNkgpspvssegikdffsmkpewenlNQSNVRRMHTAVRLNEVIVNKSRDAKLVLLNMPGPPRN 1079
Cdd:TIGR00930  863 -KDPKMTWTKPWKITDAE------------------------LQSNVRKSYRQVRLNELLLEYSRDAALVVLSLPVPRKG 917
                         1130      1140      1150
                   ....*....|....*....|....*....|....*.
gi 158711686  1080 RNGDENYMEFLEVLTEQLDRVMLVRGGGREVITIYS 1115
Cdd:TIGR00930  918 SIPDELYMAWLEVLSEDLPPVLLVRGNHRNVLTFYS 953
AA_permease pfam00324
Amino acid permease;
102-675 7.99e-45

Amino acid permease;


Pssm-ID: 366028 [Multi-domain]  Cd Length: 467  Bit Score: 169.04  E-value: 7.99e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   102 GVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATNGVVpAGGSYYMISRSLGPEFGGAVG 181
Cdd:pfam00324    1 HVQMIALGGVIGTGLFVGSGSVLGQAGPAGALLGYLISGVVIFLVMLSLGEISTNGPV-SGGFYTYASRFLGPSLGFATG 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   182 LcFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKAEdasgeaaamlnnmrVYGTCVLTCMATVVFVGVKYVNKFALVFLG 261
Cdd:pfam00324   80 W-NYWLSWITVLALELTAASILIQFWELVPDIPYLW--------------VWGAVFLVLLTIINLVGVKWYGEAEFWFAL 144
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   262 CVILSILAIYAGVIksafdppnfpicllgnrtlsrhgfdvcaklawegnetvttrlwGLFCSSRLLNATCDEYFTRNnvt 341
Cdd:pfam00324  145 IKIIAIIGFIIVGI-------------------------------------------ILLSGGNPNDGAIFRYLGDN--- 178
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   342 eiqgipgaasgLIKENLwSSYLTKGVIverrgmpsvgladgtpvdmdhpYVFSdmtsyftllvgIYFPSVTGIMAGSNRS 421
Cdd:pfam00324  179 -----------GGKNNF-PPGFGKGFI----------------------SVFV-----------IAFFAFTGIELVGIAA 213
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   422 GDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVV------GTLAWPSpwVIVIGSFFST 495
Cdd:pfam00324  214 GEVKNPEKSIPKAILQVIWRITIFYILSLLAIGLLVPWNDPGLLNDSASAASPFViffkflGISGLAP--LINAVILTAA 291
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   496 CGAGLQSLTGAPRLLQAISRDGIVPFlqVFGHGKANGEPTWALLLTACICEIGILIASLdeVAPILSMFFLMCYMFVNLA 575
Cdd:pfam00324  292 LSAANSSLYSGSRMLYSLARDGLAPK--FLKKVDKRGVPLRAILVSMVISLLALLLASL--NPAIVFNFLLAISGLSGLI 367
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   576 CAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARY 655
Cdd:pfam00324  368 VWGLISLSHLRFRKAFKYQGRSIDELPFKAPLGPLGVILGLAAIIIILIIQFLYAFLPVPGGPKNWGAGSFAAAYLIVLL 447
                          570       580
                   ....*....|....*....|
gi 158711686   656 ALLRLEEGPPHTKNWRPQLL 675
Cdd:pfam00324  448 FLIILIGVKLHVKNWKPQLL 467
PotE COG0531
Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
110-635 7.44e-33

Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];


Pssm-ID: 440297 [Multi-domain]  Cd Length: 438  Bit Score: 133.10  E-value: 7.44e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686  110 NIFGVILFLRLTWVVGIAG--IMESFCMVFICCsctMLTAISMSAIATNgvVP-AGGSYYMISRSLGPEFGGAVGLCFYL 186
Cdd:COG0531    25 AIIGAGIFVLPGLAAGLAGpaAILAWLIAGLLA---LLVALSYAELASA--FPrAGGAYTYARRALGPLLGFLAGWALLL 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686  187 GTTFAGAMYILGTIEiLLAYLFPAMAIFkaedasgeaaamlnnmrVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILS 266
Cdd:COG0531   100 SYVLAVAAVAVAFGG-YLSSLFPAGGSV-----------------LIALVLILLLTLLNLRGVKESAKVNNILTVLKLLV 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686  267 ILAIYAGVIkSAFDPPNFpicllgnrtlsrHGFDvcaklawegneTVTTRLWGLFcssrllnatcdeyftrnnvteiqgi 346
Cdd:COG0531   162 LLLFIVVGL-FAFDPANF------------TPFL-----------PAGGGLSGVL------------------------- 192
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686  347 pgAASGLIkenlwssyltkgviverrgmpsvgladgtpvdmdhpyvfsdmtsyftllvgiyFPSVTGIMAGSNRSGDLRD 426
Cdd:COG0531   193 --AALALA-----------------------------------------------------FFAFTGFEAIANLAEEAKN 217
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686  427 AQKSIPTGTILAIATTSAVYISSVVLFGacieGVVLRDKFGEAVNGNLVVGTLAWPSP--WVIVIGSFFSTCGAGLQSLT 504
Cdd:COG0531   218 PKRNIPRAIILSLLIVGVLYILVSLALT----GVVPYDELAASGAPLADAAEAVFGPWgaILIALGALLSLLGALNASIL 293
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686  505 GAPRLLQAISRDGIVPflQVFGH-GKANGEPTWALLLTACICEIGILI--ASLDEVAPILSMFFLMCYMFVNLACAVQtL 581
Cdd:COG0531   294 GASRLLYAMARDGLLP--KVFAKvHPRFGTPVNAILLTGVIALLLLLLgaASFTALASLASVGVLLAYLLVALAVIVL-R 370
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 158711686  582 LRTPNWRPRFRYYHWTLSFLGMSLCLALMFIC---SWYYALVAMLIAGLIYKYIEYR 635
Cdd:COG0531   371 RRRPDLPRPFRVPLPLIPILGILLCLFLLYLLgpgALLIGLVLLAIGLLLYLLYRRR 427
 
Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
21-1115 0e+00

K-Cl cotransporter; [Transport and binding proteins, Other]


Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 1342.06  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686    21 NPKESSPFINSTDTEKGREYDGRNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSREHEEAENNEGGKKKPV-QAPRMGT 99
Cdd:TIGR00930    1 NTVDAVPRIEHYRNSEGQGGPKRNRPSLEELHDLLDKVVSLLGPLADYTNNGQGMKEHEEAEDAEGTKEKPPaGAVKFGW 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   100 FMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGA 179
Cdd:TIGR00930   81 VMGVLVPCLLNIWGVILFLRLSWIVGQAGIGLSLLIILLCCCVTTITGLSMSAIATNGVVKGGGAYYLISRSLGPEFGGS 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   180 VGLCFYLGTTFAGAMYILGTIEILLAylfpamaIFKaEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVF 259
Cdd:TIGR00930  161 IGLIFAFANAVAVAMYVVGFAETVLD-------LLR-ENGSKIMVDPINDIRIYGTVTVVVLLGISFAGMEWENKAQVLF 232
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   260 LGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHgfdvcaklawegnetvttrlwglfcssrllnatcdeyftrnn 339
Cdd:TIGR00930  233 LVIVLLSILNIFVGTIIPAFDKPAKGFFGLGNEIFSEN------------------------------------------ 270
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   340 vtEIQGIPGAASGlikenlwssyltkgviverrgmpsvgladgtpvdmdhpyvfsdmtsyFTLLVGIYFPSVTGIMAGSN 419
Cdd:TIGR00930  271 --FIPGIPGPEGG-----------------------------------------------FFSLFGIFFPSVTGILAGAN 301
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   420 RSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVN---------------------GNLVVGT 478
Cdd:TIGR00930  302 ISGDLKDPQKAIPKGTLLAILTTTVVYLGSVVLFGACVVRDATGDKNDTLVTnctsaacfsecahntcsyglmNNLQVMS 381
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   479 LAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKA-NGEPTWALLLTACICEIGILIASLDEV 557
Cdd:TIGR00930  382 LVSPFPPLITAGIFSATLSSALASLVSAPRLFQALCKDNIYPFLQFFGKGYGkNGEPLRAYLLTAFIAEGFILIAELNTI 461
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   558 APILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGA 637
Cdd:TIGR00930  462 APIISNFFLASYALINFSCFHASLLRSPGWRPRFKYYHWWLSLLGASLCCAIMFLISWWAALVAMVIALFLYKYVTYKKP 541
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   638 EKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDqdqnVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLD 717
Cdd:TIGR00930  542 DVNWGSSTQALSYSLALYSLLRLEEVEDHVKNWRPQCLVLTGPP----VCRPALLDFASQFTKGKGLMICGSVIQGPRLE 617
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   718 NHPQAQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQkEDHQTWRNFIELVRE 797
Cdd:TIGR00930  618 CVKEAQAAEAKIQTWLEKNKVKAFYAVVVADDLREGVRHLIQASGLGRMKPNTLVMGYKKDWRQ-AEPRAWETYIGIIHD 696
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   798 TTAGHLALLVTKNVSMFPGNP--------------------------------------ERFSEGSIDVWWIVHDGGMLM 839
Cdd:TIGR00930  697 AFDAHLAVVVVRNSEGLPISVlqvqeelendcsedsielndgkistqpdmhleastqfqKKQGKGTIDVWWLVDDGGLTL 776
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   840 LLPFLLRHHKVWRKCKMRIFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMhesDISAytYEKTLVMEQRSQILKQM 919
Cdd:TIGR00930  777 LLPYLLTTKKVWKKCKIRIFVGAQKDDRSEQEKKDMATLLYKFRIDAEVIVVLM---DINA--KPQTESMEAFEEMIRPF 851
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   920 HLTKNEREREIqsitdesrgsirrknpanprlrlnvpeetacdneekpeeevqlihdqsapscpssspspgeepegeret 999
Cdd:TIGR00930  852 RLHKTEKDREA--------------------------------------------------------------------- 862
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686  1000 dPEVHLTWTKDKSVAEKNkgpspvssegikdffsmkpewenlNQSNVRRMHTAVRLNEVIVNKSRDAKLVLLNMPGPPRN 1079
Cdd:TIGR00930  863 -KDPKMTWTKPWKITDAE------------------------LQSNVRKSYRQVRLNELLLEYSRDAALVVLSLPVPRKG 917
                         1130      1140      1150
                   ....*....|....*....|....*....|....*.
gi 158711686  1080 RNGDENYMEFLEVLTEQLDRVMLVRGGGREVITIYS 1115
Cdd:TIGR00930  918 SIPDELYMAWLEVLSEDLPPVLLVRGNHRNVLTFYS 953
AA_permease pfam00324
Amino acid permease;
102-675 7.99e-45

Amino acid permease;


Pssm-ID: 366028 [Multi-domain]  Cd Length: 467  Bit Score: 169.04  E-value: 7.99e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   102 GVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATNGVVpAGGSYYMISRSLGPEFGGAVG 181
Cdd:pfam00324    1 HVQMIALGGVIGTGLFVGSGSVLGQAGPAGALLGYLISGVVIFLVMLSLGEISTNGPV-SGGFYTYASRFLGPSLGFATG 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   182 LcFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKAEdasgeaaamlnnmrVYGTCVLTCMATVVFVGVKYVNKFALVFLG 261
Cdd:pfam00324   80 W-NYWLSWITVLALELTAASILIQFWELVPDIPYLW--------------VWGAVFLVLLTIINLVGVKWYGEAEFWFAL 144
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   262 CVILSILAIYAGVIksafdppnfpicllgnrtlsrhgfdvcaklawegnetvttrlwGLFCSSRLLNATCDEYFTRNnvt 341
Cdd:pfam00324  145 IKIIAIIGFIIVGI-------------------------------------------ILLSGGNPNDGAIFRYLGDN--- 178
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   342 eiqgipgaasgLIKENLwSSYLTKGVIverrgmpsvgladgtpvdmdhpYVFSdmtsyftllvgIYFPSVTGIMAGSNRS 421
Cdd:pfam00324  179 -----------GGKNNF-PPGFGKGFI----------------------SVFV-----------IAFFAFTGIELVGIAA 213
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   422 GDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVV------GTLAWPSpwVIVIGSFFST 495
Cdd:pfam00324  214 GEVKNPEKSIPKAILQVIWRITIFYILSLLAIGLLVPWNDPGLLNDSASAASPFViffkflGISGLAP--LINAVILTAA 291
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   496 CGAGLQSLTGAPRLLQAISRDGIVPFlqVFGHGKANGEPTWALLLTACICEIGILIASLdeVAPILSMFFLMCYMFVNLA 575
Cdd:pfam00324  292 LSAANSSLYSGSRMLYSLARDGLAPK--FLKKVDKRGVPLRAILVSMVISLLALLLASL--NPAIVFNFLLAISGLSGLI 367
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   576 CAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARY 655
Cdd:pfam00324  368 VWGLISLSHLRFRKAFKYQGRSIDELPFKAPLGPLGVILGLAAIIIILIIQFLYAFLPVPGGPKNWGAGSFAAAYLIVLL 447
                          570       580
                   ....*....|....*....|
gi 158711686   656 ALLRLEEGPPHTKNWRPQLL 675
Cdd:pfam00324  448 FLIILIGVKLHVKNWKPQLL 467
PotE COG0531
Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
110-635 7.44e-33

Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];


Pssm-ID: 440297 [Multi-domain]  Cd Length: 438  Bit Score: 133.10  E-value: 7.44e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686  110 NIFGVILFLRLTWVVGIAG--IMESFCMVFICCsctMLTAISMSAIATNgvVP-AGGSYYMISRSLGPEFGGAVGLCFYL 186
Cdd:COG0531    25 AIIGAGIFVLPGLAAGLAGpaAILAWLIAGLLA---LLVALSYAELASA--FPrAGGAYTYARRALGPLLGFLAGWALLL 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686  187 GTTFAGAMYILGTIEiLLAYLFPAMAIFkaedasgeaaamlnnmrVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILS 266
Cdd:COG0531   100 SYVLAVAAVAVAFGG-YLSSLFPAGGSV-----------------LIALVLILLLTLLNLRGVKESAKVNNILTVLKLLV 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686  267 ILAIYAGVIkSAFDPPNFpicllgnrtlsrHGFDvcaklawegneTVTTRLWGLFcssrllnatcdeyftrnnvteiqgi 346
Cdd:COG0531   162 LLLFIVVGL-FAFDPANF------------TPFL-----------PAGGGLSGVL------------------------- 192
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686  347 pgAASGLIkenlwssyltkgviverrgmpsvgladgtpvdmdhpyvfsdmtsyftllvgiyFPSVTGIMAGSNRSGDLRD 426
Cdd:COG0531   193 --AALALA-----------------------------------------------------FFAFTGFEAIANLAEEAKN 217
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686  427 AQKSIPTGTILAIATTSAVYISSVVLFGacieGVVLRDKFGEAVNGNLVVGTLAWPSP--WVIVIGSFFSTCGAGLQSLT 504
Cdd:COG0531   218 PKRNIPRAIILSLLIVGVLYILVSLALT----GVVPYDELAASGAPLADAAEAVFGPWgaILIALGALLSLLGALNASIL 293
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686  505 GAPRLLQAISRDGIVPflQVFGH-GKANGEPTWALLLTACICEIGILI--ASLDEVAPILSMFFLMCYMFVNLACAVQtL 581
Cdd:COG0531   294 GASRLLYAMARDGLLP--KVFAKvHPRFGTPVNAILLTGVIALLLLLLgaASFTALASLASVGVLLAYLLVALAVIVL-R 370
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 158711686  582 LRTPNWRPRFRYYHWTLSFLGMSLCLALMFIC---SWYYALVAMLIAGLIYKYIEYR 635
Cdd:COG0531   371 RRRPDLPRPFRVPLPLIPILGILLCLFLLYLLgpgALLIGLVLLAIGLLLYLLYRRR 427
SLC12 pfam03522
Solute carrier family 12;
689-1115 1.31e-22

Solute carrier family 12;


Pssm-ID: 460955  Cd Length: 414  Bit Score: 101.93  E-value: 1.31e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   689 PQLLSLTSQLKAGKGLTIVGSVLEGTfldnHPQAQRAE--ESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGL 766
Cdd:pfam03522    2 PALVDFAHLITKNVSLMICGHVVKGR----LSQKLRSElqKKAYRWLRKRKIKAFYALVDGDNLREGAQALLQASGLGKL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   767 QHNTVLVGWPRNWR-----------------------------------------------------------QKEDHQT 787
Cdd:pfam03522   78 KPNILLMGYKSDWRtcdkeeleeyfnvihdafdlqyavailrlpegldvshllqdqdteelglgdetnssyaeQSSEEQS 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   788 WRNFIELVRETTAGH-------LALLVTKNVSMFPGNPE------------------------------RFSEGSIDVWW 830
Cdd:pfam03522  158 TSNSKQDDDKSKLSKkdsnlslSPDKSTKNPSGKDSSKSdklkkkspsiilrtasnekeilnnitqfqkKQKKGTIDVWW 237
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   831 IVHDGGMLMLLPFLLRHHKVWRKCKMRIFTVAQMDDNSIQMKKDLTTFLYHLRIT-AEVEVVemheSDISAYTYEKTlvm 909
Cdd:pfam03522  238 LYDDGGLTLLLPYILSTRSKWSDCKLRVFALGNRKDELEEEQRNMASLLSKFRIDySDLTVI----PDITKKPKKET--- 310
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   910 eqrsqilKQMH--LTKNEREREiqsitdesrgsirrknpanprlrlnvpeetacdnEEKPEEEVQLIhdqsapscpsssp 987
Cdd:pfam03522  311 -------KKFFdeLIEPFRLHE----------------------------------DDKEEESAEKI------------- 336
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   988 spgeepegereTDPEVHLtwTKDKSvaeknkgpspvssegikdffsmkpewenlnqsnvRRMhtaVRLNEVIVNKSRDAK 1067
Cdd:pfam03522  337 -----------TDSELEA--LKEKT----------------------------------NRQ---LRLRELLLEHSSDAN 366
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*...
gi 158711686  1068 LVLLNMPGPPRNRNGDENYMEFLEVLTEQLDRVMLVRGGGREVITIYS 1115
Cdd:pfam03522  367 LIVMTLPMPRKGTVSAPLYMAWLETLTKDLPPFLLVRGNQTSVLTFYS 414
AA_permease_2 pfam13520
Amino acid permease;
384-632 2.54e-14

Amino acid permease;


Pssm-ID: 404414 [Multi-domain]  Cd Length: 427  Bit Score: 76.58  E-value: 2.54e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   384 PVDMDHPYVFSDMTSYFTLLVGIYFpSVTGIMAGSNRSGDLRdaQKSIPTGTILAIATTSAVYISSVVLFGACI--EGVV 461
Cdd:pfam13520  175 LSGEWHTFFPDGWPGVFAGFLGVLW-SFTGFESAANVSEEVK--KRNVPKAIFIGVIIVGVLYILVNIAFFGVVpdDEIA 251
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   462 LRD-------KFGEAVNGNLVVGtlawpspwVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEP 534
Cdd:pfam13520  252 LSSglgqvaaLLFQAVGGKWGAI--------IVVILLALSLLGAVNTAIVGASRLLYALARDGVLPFSRFFAKVNKFGSP 323
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   535 TWALLLTACICEIGILIASLDEVAPI----LSMFFLMCYMFVNLACAVqtLLRTPNWRPRFRYYHWTLSFLGMsLCLALM 610
Cdd:pfam13520  324 IRAIILTAILSLILLLLFLLSPAAYNallsLSAYGYLLSYLLPIIGLL--ILRKKRPDLGRIPGRWPVAIFGI-LFSLFL 400
                          250       260
                   ....*....|....*....|..
gi 158711686   611 FICSWYYALVAMLIAGLIYKYI 632
Cdd:pfam13520  401 IVALFFPPVGPATGSSLNYAII 422
2A0308 TIGR00911
L-type amino acid transporter; [Transport and binding proteins, Amino acids, peptides and ...
422-623 4.27e-04

L-type amino acid transporter; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273332 [Multi-domain]  Cd Length: 501  Bit Score: 44.35  E-value: 4.27e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   422 GDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVN-GNLVVGTLAWPSPwvIVIGsfFSTCGAGL 500
Cdd:TIGR00911  259 EEVKNPYRTLPIAIIISMPIVTFIYVLTNIAYFTVLSPEELLASLAVAVDfGERLLGVMSWAMP--ALVG--LSCFGSVN 334
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158711686   501 QSLTGAPRLLQAISRDGIVPFLQVFGHGKANgEPTWALLLTaciCEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQT 580
Cdd:TIGR00911  335 GSLFSSSRLFFVGGREGHLPSLLSMIHVKRL-TPLPSLLIV---CTLTLLMLFSGDIYSLINLISFANWLFNALAVAGLL 410
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 158711686   581 LLR--TPNWRPRFRyyhwtlsflgMSLCLALMFICSWYYALVAML 623
Cdd:TIGR00911  411 WLRykRPEMNRPIK----------VPLFFPVFFLLSCLFLIILSL 445
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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