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Conserved domains on  [gi|55741643|ref|NP_065856|]
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kelch-like protein 14 [Homo sapiens]

Protein Classification

kelch-like protein 14( domain architecture ID 13033046)

kelch-like protein 14 (KLHL14) is a novel torsinA-interacting protein implicated in dystonia pathogenesis

Gene Symbol:  KLHL14
Gene Ontology:  GO:0005515
PubMed:  23676014|15544948|17120193

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB_POZ_KLHL14_printor cd18243
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1-188 4.36e-71

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349552 [Multi-domain]  Cd Length: 130  Bit Score: 225.69  E-value: 4.36e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643   1 MSRSGDRTSTFDPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSshpplgggvggqdglga 80
Cdd:cd18243   1 MSRSGDRTSTFDPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFS----------------- 63

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  81 pkdqqqppqqqpsqqqqpppqeepgtpssspddklltspraINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSV 160
Cdd:cd18243  64 -----------------------------------------INNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSV 102

                       170       180
                ....*....|....*....|....*...
gi 55741643 161 SKILHIPQVTKLCVQFLNDQISVQNYKQ 188
Cdd:cd18243 103 SKILHIPQVTKLCVQFLNDQISVQNYKQ 130
BACK_KLHL14 cd18453
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 14 (KLHL14); KLHL14, also ...
 181-282 4.92e-69

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 14 (KLHL14); KLHL14, also termed protein interactor of Torsin-1A, or Printor, or protein interactor of torsinA, is a novel ATP-free form of torsinA-interacting protein implicated in dystonia pathogenesis.


:

Pssm-ID: 350528  Cd Length: 102  Bit Score: 219.12  E-value: 4.92e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643 181 ISVQNYKQVCKIAALHGLEETKKLANKYLVEDVLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDL 260
Cdd:cd18453   1 ISVQNYKQVCKIAALHGLEETKKLANKYLVEDVLLLNFEEMRAMLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDL 80

                        90       100
                ....*....|....*....|..
gi 55741643 261 MKRLRFALIPAPELVERVQSVD 282
Cdd:cd18453  81 MKRLRFALIPAPELVERVQSVD 102
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
324-577 1.93e-47

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 168.03  E-value: 1.93e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643 324 LLLVGGLPPGpdrLPSNLVQYYDDEKKTWKILTIMPYNSAHH-CVVEVENFLFVLGGEDQWNPNGKHSTNfVSRYDPRFN 402
Cdd:COG3055  25 VYVAGGLSGG---SASNSFEVYDPATNTWSELAPLPGPPRHHaAAVAQDGKLYVFGGFTGANPSSTPLND-VYVYDPATN 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643 403 SWIQLPPMQERRASFYACRLDKHLYVIGGRNETGYLSSVECYNLETNEWRYVSSLPQPLAAHAGAVH-NGKIYISGGVHN 481
Cdd:COG3055 101 TWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHLAAAVLpDGKILVIGGRNG 180

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643 482 GEYVpwlycydpvmDVWARKQDMNTKRAIHTLAVMNDRLYAIGGNHlkGFSHLdvmlVECYDPKGDQWNILqTPILEGRS 561
Cdd:COG3055 181 SGFS----------NTWTTLAPLPTARAGHAAAVLGGKILVFGGES--GFSDE----VEAYDPATNTWTAL-GELPTPRH 243

                       250
                ....*....|....*.
gi 55741643 562 GPGCAVLDDSIYLVGG 577
Cdd:COG3055 244 GHAAVLTDGKVYVIGG 259
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 560-602 1.86e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


:

Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 42.21  E-value: 1.86e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 55741643   560 RSGPGCAVLDDSIYLVGGysWSMGAYKSSTICYCPEKGTWTEL 602
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGG--FDGNQSLNSVEVYDPETNTWSKL 42
 
Name Accession Description Interval E-value
BTB_POZ_KLHL14_printor cd18243
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1-188 4.36e-71

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349552 [Multi-domain]  Cd Length: 130  Bit Score: 225.69  E-value: 4.36e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643   1 MSRSGDRTSTFDPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSshpplgggvggqdglga 80
Cdd:cd18243   1 MSRSGDRTSTFDPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFS----------------- 63

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  81 pkdqqqppqqqpsqqqqpppqeepgtpssspddklltspraINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSV 160
Cdd:cd18243  64 -----------------------------------------INNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSV 102

                       170       180
                ....*....|....*....|....*...
gi 55741643 161 SKILHIPQVTKLCVQFLNDQISVQNYKQ 188
Cdd:cd18243 103 SKILHIPQVTKLCVQFLNDQISVQNYKQ 130
BACK_KLHL14 cd18453
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 14 (KLHL14); KLHL14, also ...
 181-282 4.92e-69

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 14 (KLHL14); KLHL14, also termed protein interactor of Torsin-1A, or Printor, or protein interactor of torsinA, is a novel ATP-free form of torsinA-interacting protein implicated in dystonia pathogenesis.


Pssm-ID: 350528  Cd Length: 102  Bit Score: 219.12  E-value: 4.92e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643 181 ISVQNYKQVCKIAALHGLEETKKLANKYLVEDVLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDL 260
Cdd:cd18453   1 ISVQNYKQVCKIAALHGLEETKKLANKYLVEDVLLLNFEEMRAMLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDL 80

                        90       100
                ....*....|....*....|..
gi 55741643 261 MKRLRFALIPAPELVERVQSVD 282
Cdd:cd18453  81 MKRLRFALIPAPELVERVQSVD 102
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
324-577 1.93e-47

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 168.03  E-value: 1.93e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643 324 LLLVGGLPPGpdrLPSNLVQYYDDEKKTWKILTIMPYNSAHH-CVVEVENFLFVLGGEDQWNPNGKHSTNfVSRYDPRFN 402
Cdd:COG3055  25 VYVAGGLSGG---SASNSFEVYDPATNTWSELAPLPGPPRHHaAAVAQDGKLYVFGGFTGANPSSTPLND-VYVYDPATN 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643 403 SWIQLPPMQERRASFYACRLDKHLYVIGGRNETGYLSSVECYNLETNEWRYVSSLPQPLAAHAGAVH-NGKIYISGGVHN 481
Cdd:COG3055 101 TWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHLAAAVLpDGKILVIGGRNG 180

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643 482 GEYVpwlycydpvmDVWARKQDMNTKRAIHTLAVMNDRLYAIGGNHlkGFSHLdvmlVECYDPKGDQWNILqTPILEGRS 561
Cdd:COG3055 181 SGFS----------NTWTTLAPLPTARAGHAAAVLGGKILVFGGES--GFSDE----VEAYDPATNTWTAL-GELPTPRH 243

                       250
                ....*....|....*.
gi 55741643 562 GPGCAVLDDSIYLVGG 577
Cdd:COG3055 244 GHAAVLTDGKVYVIGG 259
PHA03098 PHA03098
kelch-like protein; Provisional
 138-600 4.57e-44

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 165.33  E-value: 4.57e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  138 VLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQNYKQVCKIAALHGLeetKKLANK---------- 207
Cdd:PHA03098  62 VIKYIYTGKINITSNNVKDILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGC---KKLYSAaynyirnnie 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  208 --YLVEDVLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMKRLRFALIpAPELVERVqsvdfmr 285
Cdd:PHA03098 139 liYNDPDFIYLSKNELIKILSDDKLNVSSEDVVLEIIIKWLTSKKNNKYKDICLILKVLRITFL-SEEGIKKL------- 210

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  286 tdpvcqKLLLDAMNYHLMPFRQHCRQSLASRIRSNKKMLLLVGGLP------PGPDRLPSNLVQYYDDEKKTWKILTImP 359
Cdd:PHA03098 211 ------KRWKLRIKKKKIVFNKRCIKIIYSKKYNLNKILPRSSTFGsiiyihITMSIFTYNYITNYSPLSEINTIIDI-H 283

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  360 YNSAHHCVVEvENFLFVLGGEDQWNpngkHSTNFVSRYDPRFNSWIQLPPMQERRASFYACRLDKHLYVIGGRNETGYLS 439
Cdd:PHA03098 284 YVYCFGSVVL-NNVIYFIGGMNKNN----LSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLN 358

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  440 SVECYNLETNEWRYVSSLPQPLAAHAGAVHNGKIYISGGVH-NGEYVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMND 518
Cdd:PHA03098 359 TVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGGISkNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDG 438

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  519 RLYAIGgnhlkGFSHLDVML----VECYDPKGDQWNILqTPILEGRSGPGCAVLDDSIYLVGGYswsMGAYKSSTI-CYC 593
Cdd:PHA03098 439 KIYVIG-----GISYIDNIKvyniVESYNPVTNKWTEL-SSLNFPRINASLCIFNNKIYVVGGD---KYEYYINEIeVYD 509


                 ....*..
gi 55741643  594 PEKGTWT 600
Cdd:PHA03098 510 DKTNTWT 516
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 23-181 1.04e-20

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 87.31  E-value: 1.04e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643    23 LNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPplgggvggqdglgapkdqqqppqqqpsqqqqpppqe 102
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQE------------------------------------ 44

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 55741643   103 epgtpssspddklltSPRAINNLVLQGCSSIGLRLVLEYLYTANvTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQI 181
Cdd:pfam00651  45 ---------------SESSVSEITLDDVSPEDFEALLEFMYTGK-LISEENVDDLLAAADKLQIPSLVDKCEEFLIKSL 107
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 189-277 6.63e-14

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 67.75  E-value: 6.63e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643    189 VCKIAALHGLEETKKLANKYLV---------EDVLLLNFEEMRALL--DSLPppVESELALFQMSVLWLEHDRETRMQYA 257
Cdd:smart00875   4 IRRFADAHGLEELAEKALRFILqnfsevsssEEFLELPLEQLLELLssDDLN--VSSEEEVFEAVLRWVKHDPEKRREHL 81

                           90       100
                   ....*....|....*....|
gi 55741643    258 PDLMKRLRFALIPAPELVER 277
Cdd:smart00875  82 PELLEHVRLPLLSPDYLLEV 101
Kelch smart00612
Kelch domain;
425-471 1.43e-13

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 65.27  E-value: 1.43e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 55741643    425 HLYVIGGRNETGYLSSVECYNLETNEWRYVSSLPQPLAAHAGAVHNG 471
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 34-181 2.41e-13

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 66.18  E-value: 2.41e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643     34 DVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPplgggvggqdglgapkdqqqppqqqpsqqqqpppqeepgtpssSPDD 113
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDF-------------------------------------------KESD 37

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 55741643    114 KlltspraiNNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQI 181
Cdd:smart00225  38 K--------SEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYLQIPGLVELCEEFLLKLL 97
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 192-279 5.24e-13

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 65.26  E-value: 5.24e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643   192 IAALHGLEETKKLANKYLV---------EDVLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMK 262
Cdd:pfam07707   7 FADAYGCTELAEAALRFILqnflevaksEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKHLPELLS 86

                          90
                  ....*....|....*..
gi 55741643   263 RLRFALIPAPELVERVQ 279
Cdd:pfam07707  87 AVRLPLLSPQYLLNLVE 103
PHA02713 PHA02713
hypothetical protein; Provisional
 12-478 6.86e-13

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 71.58  E-value: 6.86e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643   12 DPSHSDNLLHGLNLLWRKQLFCDVTLT-AQGQQFHCHKAVLASCSQYFRSLFsshpplgggvggqdglgapkdqqqppqq 90
Cdd:PHA02713   5 DIKHNRRVVSNISNLLDDDILCDVIITiGDGEEIKAHKTILAAGSKYFRTLF---------------------------- 56

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643   91 qpsqqqqpppqeepgtpssspddkllTSPRAINNLV----LQGCSSIGLRLVLEYLYtaNVTLSLDTVEEVLSVSKILHI 166
Cdd:PHA02713  57 --------------------------TTPMIIRDLVtrvnLQMFDKDAVKNIVQYLY--NRHISSMNVIDVLKCADYLLI 108

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  167 PQVTKLCVQFLNDQISvqnyKQVCkIAALHGLEETKKLANKYLVEDVLLLNFEEM-----------RALLDSLPPPVESE 235
Cdd:PHA02713 109 DDLVTDCESYIKDYTN----HDTC-IYMYHRLYEMSHIPIVKYIKRMLMSNIPTLittdafkktvfEILFDIISTNDNVY 183

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  236 LAL--FQMSVL--WLEHDRETRMQY--------APDLMKRLRFALIpapelvervqSVDFMRTDPVCQKLLLD-AMNYHL 302
Cdd:PHA02713 184 LYRegYKVTILlkWLEYNYITEEQLlcilscidIQNLDKKSRLLLY----------SNKTINMYPSCIQFLLDnKQNRNI 253

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  303 MPfRQHCRQSLASRIRSNKKMLLLvgglppgpdrlpsnlvqyYDDEKKTWKILTIMPYNSAHHCVVEVENFLFVLGGEDQ 382
Cdd:PHA02713 254 IP-RQLCLVCHDTKYNVCNPCILV------------------YNINTMEYSVISTIPNHIINYASAIVDNEIIIAGGYNF 314

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  383 WNPngkhSTNFVSRYDPRFNSWIQLPPMQERRASFYACRLDKHLYVIGGRNETGYLSSVECYNLETNEWRYVSSLPQPLA 462
Cdd:PHA02713 315 NNP----SLNKVYKINIENKIHVELPPMIKNRCRFSLAVIDDTIYAIGGQNGTNVERTIECYTMGDDKWKMLPDMPIALS 390

                        490
                 ....*....|....*.
gi 55741643  463 AHAGAVHNGKIYISGG 478
Cdd:PHA02713 391 SYGMCVLDQYIYIIGG 406
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 413-458 9.07e-12

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 59.93  E-value: 9.07e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 55741643   413 RRASFYACRLDKHLYVIGGRNETGYLSSVECYNLETNEWRYVSSLP 458
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 560-602 1.86e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 42.21  E-value: 1.86e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 55741643   560 RSGPGCAVLDDSIYLVGGysWSMGAYKSSTICYCPEKGTWTEL 602
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGG--FDGNQSLNSVEVYDPETNTWSKL 42
muta_rot_YjhT TIGR03547
mutatrotase, YjhT family; Members of this protein family contain multiple copies of the ...
 457-578 3.86e-04

mutatrotase, YjhT family; Members of this protein family contain multiple copies of the beta-propeller-forming Kelch repeat. All are full-length homologs to YjhT of Escherichia coli, which has been identified as a mutarotase for sialic acid. This protein improves bacterial ability to obtain host sialic acid, and thus serves as a virulence factor. Some bacteria carry what appears to be a cyclically permuted homolog of this protein.


Pssm-ID: 274641 [Multi-domain]  Cd Length: 346  Bit Score: 43.08  E-value: 3.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643   457 LPQPLAAHAGAVHNGKIYI---SGGVHngeyvpWLYCYDPVMDV-WARKQDMNT-KRAIHTLAVMNDRLYAIGG---NHL 528
Cdd:TIGR03547   4 LPVGFKNGTGAIIGDKVYVglgSAGTS------WYKLDLKKPSKgWQKIADFPGgPRNQAVAAAIDGKLYVFGGigkANS 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 55741643   529 KGFSHLdVMLVECYDPKGDQWNILQTPILEGRSGPGCAVLDDS-IYLVGGY 578
Cdd:TIGR03547  78 EGSPQV-FDDVYRYDPKKNSWQKLDTRSPVGLLGASGFSLHNGqAYFTGGV 127
 
Name Accession Description Interval E-value
BTB_POZ_KLHL14_printor cd18243
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1-188 4.36e-71

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349552 [Multi-domain]  Cd Length: 130  Bit Score: 225.69  E-value: 4.36e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643   1 MSRSGDRTSTFDPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSshpplgggvggqdglga 80
Cdd:cd18243   1 MSRSGDRTSTFDPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFS----------------- 63

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  81 pkdqqqppqqqpsqqqqpppqeepgtpssspddklltspraINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSV 160
Cdd:cd18243  64 -----------------------------------------INNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSV 102

                       170       180
                ....*....|....*....|....*...
gi 55741643 161 SKILHIPQVTKLCVQFLNDQISVQNYKQ 188
Cdd:cd18243 103 SKILHIPQVTKLCVQFLNDQISVQNYKQ 130
BACK_KLHL14 cd18453
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 14 (KLHL14); KLHL14, also ...
 181-282 4.92e-69

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 14 (KLHL14); KLHL14, also termed protein interactor of Torsin-1A, or Printor, or protein interactor of torsinA, is a novel ATP-free form of torsinA-interacting protein implicated in dystonia pathogenesis.


Pssm-ID: 350528  Cd Length: 102  Bit Score: 219.12  E-value: 4.92e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643 181 ISVQNYKQVCKIAALHGLEETKKLANKYLVEDVLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDL 260
Cdd:cd18453   1 ISVQNYKQVCKIAALHGLEETKKLANKYLVEDVLLLNFEEMRAMLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDL 80

                        90       100
                ....*....|....*....|..
gi 55741643 261 MKRLRFALIPAPELVERVQSVD 282
Cdd:cd18453  81 MKRLRFALIPAPELVERVQSVD 102
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
324-577 1.93e-47

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 168.03  E-value: 1.93e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643 324 LLLVGGLPPGpdrLPSNLVQYYDDEKKTWKILTIMPYNSAHH-CVVEVENFLFVLGGEDQWNPNGKHSTNfVSRYDPRFN 402
Cdd:COG3055  25 VYVAGGLSGG---SASNSFEVYDPATNTWSELAPLPGPPRHHaAAVAQDGKLYVFGGFTGANPSSTPLND-VYVYDPATN 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643 403 SWIQLPPMQERRASFYACRLDKHLYVIGGRNETGYLSSVECYNLETNEWRYVSSLPQPLAAHAGAVH-NGKIYISGGVHN 481
Cdd:COG3055 101 TWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHLAAAVLpDGKILVIGGRNG 180

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643 482 GEYVpwlycydpvmDVWARKQDMNTKRAIHTLAVMNDRLYAIGGNHlkGFSHLdvmlVECYDPKGDQWNILqTPILEGRS 561
Cdd:COG3055 181 SGFS----------NTWTTLAPLPTARAGHAAAVLGGKILVFGGES--GFSDE----VEAYDPATNTWTAL-GELPTPRH 243

                       250
                ....*....|....*.
gi 55741643 562 GPGCAVLDDSIYLVGG 577
Cdd:COG3055 244 GHAAVLTDGKVYVIGG 259
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
351-618 4.28e-47

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 166.87  E-value: 4.28e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643 351 TWKILTIMPYNSAHHCVVEVENFLFVLGGEDQWNPngkhsTNFVSRYDPRFNSWIQLPPMQERRASFYACRL-DKHLYVI 429
Cdd:COG3055   2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSA-----SNSFEVYDPATNTWSELAPLPGPPRHHAAAVAqDGKLYVF 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643 430 GGRNE----TGYLSSVECYNLETNEWRYVSSLPQPLAAHAGAVHNGKIYISGGVHNGEYVPWLYCYDPVMDVWARKQDMN 505
Cdd:COG3055  77 GGFTGanpsSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLP 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643 506 TKRAIHTLAVM-NDRLYAIGGNHLKGFShldvmlvecydpkgDQWNILQtPILEGRSGPGCAVLDDSIYLVGGYS-WSMG 583
Cdd:COG3055 157 TPRDHLAAAVLpDGKILVIGGRNGSGFS--------------NTWTTLA-PLPTARAGHAAAVLGGKILVFGGESgFSDE 221

                       250       260       270
                ....*....|....*....|....*....|....*
gi 55741643 584 AYksstiCYCPEKGTWTELeGDVAEPLAGPACVTV 618
Cdd:COG3055 222 VE-----AYDPATNTWTAL-GELPTPRHGHAAVLT 250
PHA03098 PHA03098
kelch-like protein; Provisional
 138-600 4.57e-44

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 165.33  E-value: 4.57e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  138 VLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQNYKQVCKIAALHGLeetKKLANK---------- 207
Cdd:PHA03098  62 VIKYIYTGKINITSNNVKDILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGC---KKLYSAaynyirnnie 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  208 --YLVEDVLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMKRLRFALIpAPELVERVqsvdfmr 285
Cdd:PHA03098 139 liYNDPDFIYLSKNELIKILSDDKLNVSSEDVVLEIIIKWLTSKKNNKYKDICLILKVLRITFL-SEEGIKKL------- 210

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  286 tdpvcqKLLLDAMNYHLMPFRQHCRQSLASRIRSNKKMLLLVGGLP------PGPDRLPSNLVQYYDDEKKTWKILTImP 359
Cdd:PHA03098 211 ------KRWKLRIKKKKIVFNKRCIKIIYSKKYNLNKILPRSSTFGsiiyihITMSIFTYNYITNYSPLSEINTIIDI-H 283

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  360 YNSAHHCVVEvENFLFVLGGEDQWNpngkHSTNFVSRYDPRFNSWIQLPPMQERRASFYACRLDKHLYVIGGRNETGYLS 439
Cdd:PHA03098 284 YVYCFGSVVL-NNVIYFIGGMNKNN----LSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLN 358

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  440 SVECYNLETNEWRYVSSLPQPLAAHAGAVHNGKIYISGGVH-NGEYVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMND 518
Cdd:PHA03098 359 TVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGGISkNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDG 438

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  519 RLYAIGgnhlkGFSHLDVML----VECYDPKGDQWNILqTPILEGRSGPGCAVLDDSIYLVGGYswsMGAYKSSTI-CYC 593
Cdd:PHA03098 439 KIYVIG-----GISYIDNIKvyniVESYNPVTNKWTEL-SSLNFPRINASLCIFNNKIYVVGGD---KYEYYINEIeVYD 509


                 ....*..
gi 55741643  594 PEKGTWT 600
Cdd:PHA03098 510 DKTNTWT 516
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-185 3.75e-27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 106.32  E-value: 3.75e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSShpplgggvggqdglgapkdqqqppqqqpsq 94
Cdd:cd18255   1 HSVTLLQGLNALRAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFTG------------------------------ 50

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  95 qqqpppqeepGTPSSSPDDklltsprainnLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCV 174
Cdd:cd18255  51 ----------GMRESSQDE-----------IELKGVSAKGLKHILDFAYTSELTLDLDCIQDVLGAAVHLQMLPVVELCE 109

                       170
                ....*....|.
gi 55741643 175 QFLNDQISVQN 185
Cdd:cd18255 110 EFLKSAMSVEN 120
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 23-181 1.04e-20

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 87.31  E-value: 1.04e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643    23 LNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPplgggvggqdglgapkdqqqppqqqpsqqqqpppqe 102
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQE------------------------------------ 44

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 55741643   103 epgtpssspddklltSPRAINNLVLQGCSSIGLRLVLEYLYTANvTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQI 181
Cdd:pfam00651  45 ---------------SESSVSEITLDDVSPEDFEALLEFMYTGK-LISEENVDDLLAAADKLQIPSLVDKCEEFLIKSL 107
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-185 1.72e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 87.52  E-value: 1.72e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  12 DPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSshpplgggvggqdglgapkdqqqppqqq 91
Cdd:cd18250   1 DPAHALHLLRGLSELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMFA---------------------------- 52

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  92 psqqqqpppqeepGTPSSSPDDKlltsprainnLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTK 171
Cdd:cd18250  53 -------------GELRESRADR----------VVLHGVSAEILGLLLDFSYTGRVTVTQDNVEALLRAADLFQFPSVKE 109

                       170
                ....*....|....
gi 55741643 172 LCVQFLNDQISVQN 185
Cdd:cd18250 110 ACCAYLQQRLDVSN 123
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-185 9.39e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 85.59  E-value: 9.39e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  13 PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHpplgggvggqdglgapkdqqqppqqqp 92
Cdd:cd18265   4 PCHAERILQVLNAYRRSGTFTDVVLLVDGKDFPCHRATLSANSAYFRAMFGGH--------------------------- 56

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  93 sqqqqpppqeepgTPSSSPDdklltsprAINnlvLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKL 172
Cdd:cd18265  57 -------------LKESRQA--------VVE---IQKVSAAAMEVLLDYMYGGGLRIQEDNVESVLEASDLLQVSKLREA 112

                       170
                ....*....|...
gi 55741643 173 CVQFLNDQISVQN 185
Cdd:cd18265 113 CVRFLEGQLHPCN 125
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 32-164 1.98e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 82.99  E-value: 1.98e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  32 FCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHpplgggvggqdglgapkdqqqppqqqpsqqqqpppqeepgtpsssp 111
Cdd:cd18186   1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSG---------------------------------------------- 34

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 55741643 112 ddkllTSPRAINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKIL 164
Cdd:cd18186  35 -----MKESSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELLAAADKL 82
BTB_POZ_KLHL32 cd18261
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-186 4.33e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349570 [Multi-domain]  Cd Length: 133  Bit Score: 80.78  E-value: 4.33e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  14 SHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSshpplgggvggqdglgapkdqqqppqqqps 93
Cdd:cd18261  10 SHKDAVLAALNQQRNDGILCDITLVAEEQKFHAHKAVLAACSDYFRAMFS------------------------------ 59

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  94 qqqqpppqeepgtpssspddkLLTSPRAINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLC 173
Cdd:cd18261  60 ---------------------LCMVESEADEVNLHGVTSLGLKQALDFAYTGQILLEPGVIQDVLAAGSHLQLLELLSLC 118

                       170
                ....*....|...
gi 55741643 174 VQFLNDQISVQNY 186
Cdd:cd18261 119 SHYLIQELNSFNY 131
BTB_POZ_KLHL31_KBTBD1 cd18260
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-185 2.06e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349569 [Multi-domain]  Cd Length: 120  Bit Score: 78.70  E-value: 2.06e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPplgggvggqdglgapkdqqqppqqqpsq 94
Cdd:cd18260   1 YGANLLEGLNRMRQERFLCDLTIATKTKSFDVHKVVMASCSEYFRNILKKDP---------------------------- 52

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  95 qqqpppqeepgtpssspddklltsprAINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCV 174
Cdd:cd18260  53 --------------------------SLQRVELNDISPLGLATVITYAYTGKLTLSLYTIGSTISAASYLQIHALVKMCC 106

                       170
                ....*....|.
gi 55741643 175 QFLNDQISVQN 185
Cdd:cd18260 107 DFLMQEMNVEN 117
BTB_POZ_KLHL28_BTBD5 cd18257
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-181 4.85e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349566 [Multi-domain]  Cd Length: 118  Bit Score: 77.58  E-value: 4.85e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHpplgggvggqdglgapkdqqqppqqqpsq 94
Cdd:cd18257   1 HSEQLLQGLNLLRQHHELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFTGN----------------------------- 51

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  95 qqqpppqeepgtpssspddkllTSPRAINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCV 174
Cdd:cd18257  52 ----------------------LSEKENSEVEFQCIDETALQAIVEYAYTGTVFISQATVESLLPAANLLQIKLVLKECC 109


                ....*..
gi 55741643 175 QFLNDQI 181
Cdd:cd18257 110 DFLESQL 116
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-185 4.24e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 75.22  E-value: 4.24e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  14 SHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHpplgggvggqdglgapkdqqqppqqqps 93
Cdd:cd18264  10 SHGEAVLSQYQSLRAEGFLCDVVLEAEGNEFPAHRSLLACSSDYFRALFKDY---------------------------- 61

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  94 qqqqpppqeepgtpssspddkllTSPRAINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLC 173
Cdd:cd18264  62 -----------------------TQESKARVIHLPVVSAAGLQRVLDFIYTSWLSLSLDTLEDTLEAASYLQVTEAIGLC 118

                       170
                ....*....|..
gi 55741643 174 VQFLNDQISVQN 185
Cdd:cd18264 119 SQYLINNLAPEN 130
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-178 4.31e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 74.59  E-value: 4.31e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  13 PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSShpplgggvggqdglgapkdqqqppqqqp 92
Cdd:cd18326   6 PDHSSDILSSLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFKKLFTS---------------------------- 57

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  93 sqqqqpppqeepgtpSSSPDDKlltspraiNNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKL 172
Cdd:cd18326  58 ---------------GAVVDQQ--------NVYEIDFVSAEALTALLDFAYTATLTVSTSNVGDILSAARLLEIPAVSHV 114


                ....*.
gi 55741643 173 CVQFLN 178
Cdd:cd18326 115 CADLLD 120
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-181 1.55e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 73.36  E-value: 1.55e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  14 SHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPplgggvggqdglgapkdqqqppqqqps 93
Cdd:cd18228   1 SHSQELLGKLNSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLVGQA--------------------------- 53

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  94 qqqqpppqeEPGTPSSSPDDKLLTSpraINNLVLQGCSSIglrlvLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLC 173
Cdd:cd18228  54 ---------SPRLVLVSPAGKCVLD---LHHVTVTGFAPL-----LEYAYTSTLSINTENIIDVLAAASYMQMFNVANTC 116


                ....*...
gi 55741643 174 VQFLNDQI 181
Cdd:cd18228 117 SEFMKSSI 124
BTB_POZ_ZBTB7B_ZBTB15 cd18327
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-177 1.79e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349636 [Multi-domain]  Cd Length: 127  Bit Score: 73.34  E-value: 1.79e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  13 PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPplgggvggqdglgapkdqqqppqqqp 92
Cdd:cd18327   6 PEHSSELLSCLNEQRRAGLLCDLTIKTRGLEYRTHRAVLAACSLYFRKLFTGGG-------------------------- 59

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  93 sqqQQPPPQEEPGTPSSSPDDklLTSPRAINNLvlqgcssiglrlvLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKL 172
Cdd:cd18327  60 ---GGSGDLGAGGGQDVCELD--FVGPEALGAL-------------LEFAYTATLTISSSNMREVLRAARLLEIPCVADA 121


                ....*
gi 55741643 173 CVQFL 177
Cdd:cd18327 122 CADIL 126
BACK_KLHL3 cd18513
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as ...
 193-301 2.56e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. It is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation.


Pssm-ID: 350588 [Multi-domain]  Cd Length: 130  Bit Score: 72.79  E-value: 2.56e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643 193 AALHGLEETKKLANKY---------LVEDVLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMKR 263
Cdd:cd18513  13 ADVHTCTELLQQANAYaeqhfpevmLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWIKYDKEARLEHMAKLMEH 92

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 55741643 264 LRFALIPAPELVERVQSVDFMRTDPVCQKLLLDAMNYH 301
Cdd:cd18513  93 VRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYH 130
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-181 2.62e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 72.46  E-value: 2.62e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  13 PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHpplgggvggqdglgapkdqqqppqqqp 92
Cdd:cd18235   2 PQHTQKAFDVMNELRKQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMFTGD--------------------------- 54

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  93 sqqqqpppqeepgtpssspddklLTSPRAiNNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKL 172
Cdd:cd18235  55 -----------------------LSESRA-NRVTLQDVDGKALLLLIDYVYTAEIQVTEENVQVLLPAANLLQLTDVRDA 110


                ....*....
gi 55741643 173 CVQFLNDQI 181
Cdd:cd18235 111 CCDFLQSQL 119
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-185 2.96e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 72.44  E-value: 2.96e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSshpplgggvggqdglgapkdqqqppqqqpsq 94
Cdd:cd18256   3 HASLILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFA------------------------------- 51

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  95 qqqpppqeePGTPSSSPDDklltsprainnLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCV 174
Cdd:cd18256  52 ---------GGMSESSKDV-----------VQIHGVEPDIFHILLDFIYTGVVEVTVSNVQELLVAADMLQLTEVVEICC 111

                       170
                ....*....|.
gi 55741643 175 QFLNDQISVQN 185
Cdd:cd18256 112 EFLKGQLHPSN 122
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-185 7.37e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 71.20  E-value: 7.37e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  16 SDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHpplgggvggqdglgapkdqqqppqqqpsqq 95
Cdd:cd18240   1 SAMACNVFNELRLEGKLCDVVIRVNGVEFPAHRNILCACSPYFRALFTNG------------------------------ 50

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  96 qqpppqeepgtpSSSPDDKLLTSPrainnlvlqGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQ 175
Cdd:cd18240  51 ------------WNETEKKVYKIP---------GVSPEMMELIIEYAYTRTVPITAENVEELLPAADQFNIMGIVKACCD 109

                       170
                ....*....|
gi 55741643 176 FLNDQISVQN 185
Cdd:cd18240 110 FLEDQLCPEN 119
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-185 8.49e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 71.14  E-value: 8.49e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSShpplgggvggqdglgapkdqqqppqqqpsq 94
Cdd:cd18306   1 HPESVLAKLNALRKNRQFCDVILQVGGHEIPAHRAVLACASPYLFELFSS------------------------------ 50

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  95 qqqpppqEEPGTPssspddklltspraINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCV 174
Cdd:cd18306  51 -------DSDGES--------------ILTVKLDGLDPDAVEVLVNYAYTSRLEVPADLVKSVYSAAKKLKMDRVKKACG 109

                       170
                ....*....|.
gi 55741643 175 QFLNDQISVQN 185
Cdd:cd18306 110 DFLLEKLTPQN 120
BTB_POZ_ZBTB7 cd18198
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-177 1.49e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349507 [Multi-domain]  Cd Length: 120  Bit Score: 70.28  E-value: 1.49e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  13 PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSShpplgggvggqdglgapkdqqqppqqqp 92
Cdd:cd18198   6 PDHSSEILSGLNEQRTQGLLCDVVILVQGREYRTHRSVLAACSQYFKKLFTS---------------------------- 57

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  93 sqqqqpppqeepGTPSSSPD--DKLLTSPRAINNLvlqgcssiglrlvLEYLYTANVTLSLDTVEEVLSVSKILHIPQVT 170
Cdd:cd18198  58 ------------GAVVDQQNvyEIDFVSPEALTAL-------------LEFAYTATLTVSTANVGDILSAARLLEIPCVS 112


                ....*..
gi 55741643 171 KLCVQFL 177
Cdd:cd18198 113 HVCAEIL 119
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-177 2.22e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 69.68  E-value: 2.22e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  19 LLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPPlgggvggqdglgapkdqqqppqqqpsqqqqp 98
Cdd:cd18245   1 LLRALNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLNYNPP------------------------------- 49

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 55741643  99 ppqEEPGTPSSspddklltsprainnLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFL 177
Cdd:cd18245  50 ---KDDGSTYK---------------IELEGISVEVMEEILDYIYTGQIKLSEDNIQDIVQAADLLLMTDLKDLCCEFL 110
BACK_KLHL2_Mayven cd18512
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also ...
 193-301 3.88e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation.


Pssm-ID: 350587 [Multi-domain]  Cd Length: 130  Bit Score: 69.67  E-value: 3.88e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643 193 AALHGLEETKKLANKY---------LVEDVLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMKR 263
Cdd:cd18512  13 ADMHACTELLNQANTYaeqhfsdvvLSEEFLNLGIEQVCSLIASDKLTISSEEKVFEAVIAWVNHDKEVRQEHMAHLMEH 92

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 55741643 264 LRFALIPAPELVERVQSVDFMRTDPVCQKLLLDAMNYH 301
Cdd:cd18512  93 VRLPLLSREYLVQRVEEETLVKNSSACKDYLIEAMKYH 130
BTB_POZ_KLHL36 cd18266
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-186 4.62e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349575 [Multi-domain]  Cd Length: 135  Bit Score: 69.53  E-value: 4.62e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSshpplgggvggqdglgapkdqqqppqqqpsq 94
Cdd:cd18266   8 HSNLVLQGLNEQRQRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFT------------------------------- 56

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  95 qqqpppqeepgtpssspddklLTSPRAINNLV-LQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLC 173
Cdd:cd18266  57 ---------------------IGMREAHQKEVeLVGASYIGLKAVIDFLYSSELPLDGGNIDYVLETAHLLQIWKVVDFC 115

                       170
                ....*....|...
gi 55741643 174 VQFLNDQISVQNY 186
Cdd:cd18266 116 CEYLENEVSEENY 128
BTB_POZ_ZBTB17_MIZ1 cd18206
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-176 5.79e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349515 [Multi-domain]  Cd Length: 112  Bit Score: 68.42  E-value: 5.79e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  13 PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHpplgggvggqdglgapKDQQQppqqqp 92
Cdd:cd18206   3 PQHSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFRMLFVDQ----------------KDVVH------ 60

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  93 sqqqqpppqeepgtpssspddklltsprainnlvLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKL 172
Cdd:cd18206  61 ----------------------------------LDISNAAGLGQVLEFMYTAKLSLSPENVDDVLAVATFLQMQDIVTA 106


                ....
gi 55741643 173 CVQF 176
Cdd:cd18206 107 CHAL 110
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 189-277 6.63e-14

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 67.75  E-value: 6.63e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643    189 VCKIAALHGLEETKKLANKYLV---------EDVLLLNFEEMRALL--DSLPppVESELALFQMSVLWLEHDRETRMQYA 257
Cdd:smart00875   4 IRRFADAHGLEELAEKALRFILqnfsevsssEEFLELPLEQLLELLssDDLN--VSSEEEVFEAVLRWVKHDPEKRREHL 81

                           90       100
                   ....*....|....*....|
gi 55741643    258 PDLMKRLRFALIPAPELVER 277
Cdd:smart00875  82 PELLEHVRLPLLSPDYLLEV 101
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-185 7.42e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 68.88  E-value: 7.42e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  18 NLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSShpplgggvggqdglgapkdqqqppqqqpsqqqq 97
Cdd:cd18270  12 SLLEQLKFFYEQQLLTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMS--------------------------------- 58

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  98 pppqeepGTPSSSPddklltspraiNNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFL 177
Cdd:cd18270  59 -------GLSESKQ-----------THVHLRNVDAATLQIIITYAYTGNLAINDSTVEQLYETACFLQVEDVLQRCREYL 120


                ....*...
gi 55741643 178 NDQISVQN 185
Cdd:cd18270 121 IKKINAEN 128
PHA03098 PHA03098
kelch-like protein; Provisional
 340-458 7.91e-14

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 74.42  E-value: 7.91e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  340 NLVQYYDDEKKTWKILTIMPYNSAHHCVVEVENFLFVLGGEDqwNPNGKHSTNFVSRYDPRFNSWIQLPPMQERRASFYA 419
Cdd:PHA03098 406 KTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGIS--YIDNIKVYNIVESYNPVTNKWTELSSLNFPRINASL 483

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 55741643  420 CRLDKHLYVIGGRNETGYLSSVECYNLETNEWRYVSSLP 458
Cdd:PHA03098 484 CIFNNKIYVVGGDKYEYYINEIEVYDDKTNTWTLFCKFP 522
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-185 1.03e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 68.09  E-value: 1.03e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  23 LNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSShpplgggvggqdglgapkdqqqppqqqpsqqqqpppqe 102
Cdd:cd18238   6 LHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTS-------------------------------------- 47

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643 103 ePGTPSSSpddklltspraiNNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQIS 182
Cdd:cd18238  48 -EMAESKQ------------DSITIKDIDEEAVELLVDFAYTGKLTLTVDNVQSLLYAASLLQVEEVAKACCEFMKDHLH 114


                ...
gi 55741643 183 VQN 185
Cdd:cd18238 115 PSN 117
Kelch smart00612
Kelch domain;
425-471 1.43e-13

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 65.27  E-value: 1.43e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 55741643    425 HLYVIGGRNETGYLSSVECYNLETNEWRYVSSLPQPLAAHAGAVHNG 471
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 34-181 2.41e-13

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 66.18  E-value: 2.41e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643     34 DVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPplgggvggqdglgapkdqqqppqqqpsqqqqpppqeepgtpssSPDD 113
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDF-------------------------------------------KESD 37

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 55741643    114 KlltspraiNNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQI 181
Cdd:smart00225  38 K--------SEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYLQIPGLVELCEEFLLKLL 97
BTB_POZ_ZBTB7C_ZBTB36 cd18328
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-178 2.51e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349637 [Multi-domain]  Cd Length: 120  Bit Score: 66.83  E-value: 2.51e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  13 PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSShpplgggvggqdglgapkdqqqppqqqp 92
Cdd:cd18328   6 PNHSSEVLCSLNEQRHDGLLCDVVLIVQDQEYRTHRSVLAACSKYFKKLFTA---------------------------- 57

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  93 sqqqqpppqeepGTPSSSPD--DKLLTSPRAinnlvlqgcssigLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVT 170
Cdd:cd18328  58 ------------GTLADQPYvyEIDFVTPEA-------------LSAILEFAYTSTLTITTSNVKHILNAAQMLEIQCII 112


                ....*...
gi 55741643 171 KLCVQFLN 178
Cdd:cd18328 113 NVCLEIMD 120
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-185 3.58e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 66.78  E-value: 3.58e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  13 PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSShpplgggvggqdglgapkdqqqppqqqp 92
Cdd:cd18259  13 PSHPQSILDGLQTLRSNPKLSDVTLLVGGREFPCHRSVLALCSHYFNAMFTG---------------------------- 64

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  93 sqqqqpppqeepgtpssspddKLLTSPRAinNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKL 172
Cdd:cd18259  65 ---------------------DFVESISA--RVEIKDVDPAVMESLIDFAYTGKLTINQGNVEALIRTSNRLQFPTVRKV 121

                       170
                ....*....|...
gi 55741643 173 CVQFLNDQISVQN 185
Cdd:cd18259 122 CSRYLQQQIDATN 134
PLN02193 PLN02193
nitrile-specifier protein
 345-525 3.77e-13

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 71.91  E-value: 3.77e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  345 YDDEKKTWKILTI---MPYNSAHH-CVVEVENFLFVLGGED---QWNpngkhstNFVSrYDPRFNSWIQLPPMQERRA-- 415
Cdd:PLN02193 198 FDLETRTWSISPAtgdVPHLSCLGvRMVSIGSTLYVFGGRDasrQYN-------GFYS-FDTTTNEWKLLTPVEEGPTpr 269

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  416 SFYACRLDK-HLYVIGGRNETGYLSSVECYNLETNEWRYVSSLPQPLAAHAGA---VHNGKIYISGGVhNGEYVPWLYCY 491
Cdd:PLN02193 270 SFHSMAADEeNVYVFGGVSATARLKTLDSYNIVDKKWFHCSTPGDSFSIRGGAgleVVQGKVWVVYGF-NGCEVDDVHYY 348

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 55741643  492 DPVMDVWARKQDMNTK---RAIHTLAVMNDRLYAIGG 525
Cdd:PLN02193 349 DPVQDKWTQVETFGVRpseRSVFASAAVGKHIVIFGG 385
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 192-279 5.24e-13

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 65.26  E-value: 5.24e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643   192 IAALHGLEETKKLANKYLV---------EDVLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMK 262
Cdd:pfam07707   7 FADAYGCTELAEAALRFILqnflevaksEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKHLPELLS 86

                          90
                  ....*....|....*..
gi 55741643   263 RLRFALIPAPELVERVQ 279
Cdd:pfam07707  87 AVRLPLLSPQYLLNLVE 103
PHA02713 PHA02713
hypothetical protein; Provisional
 12-478 6.86e-13

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 71.58  E-value: 6.86e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643   12 DPSHSDNLLHGLNLLWRKQLFCDVTLT-AQGQQFHCHKAVLASCSQYFRSLFsshpplgggvggqdglgapkdqqqppqq 90
Cdd:PHA02713   5 DIKHNRRVVSNISNLLDDDILCDVIITiGDGEEIKAHKTILAAGSKYFRTLF---------------------------- 56

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643   91 qpsqqqqpppqeepgtpssspddkllTSPRAINNLV----LQGCSSIGLRLVLEYLYtaNVTLSLDTVEEVLSVSKILHI 166
Cdd:PHA02713  57 --------------------------TTPMIIRDLVtrvnLQMFDKDAVKNIVQYLY--NRHISSMNVIDVLKCADYLLI 108

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  167 PQVTKLCVQFLNDQISvqnyKQVCkIAALHGLEETKKLANKYLVEDVLLLNFEEM-----------RALLDSLPPPVESE 235
Cdd:PHA02713 109 DDLVTDCESYIKDYTN----HDTC-IYMYHRLYEMSHIPIVKYIKRMLMSNIPTLittdafkktvfEILFDIISTNDNVY 183

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  236 LAL--FQMSVL--WLEHDRETRMQY--------APDLMKRLRFALIpapelvervqSVDFMRTDPVCQKLLLD-AMNYHL 302
Cdd:PHA02713 184 LYRegYKVTILlkWLEYNYITEEQLlcilscidIQNLDKKSRLLLY----------SNKTINMYPSCIQFLLDnKQNRNI 253

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  303 MPfRQHCRQSLASRIRSNKKMLLLvgglppgpdrlpsnlvqyYDDEKKTWKILTIMPYNSAHHCVVEVENFLFVLGGEDQ 382
Cdd:PHA02713 254 IP-RQLCLVCHDTKYNVCNPCILV------------------YNINTMEYSVISTIPNHIINYASAIVDNEIIIAGGYNF 314

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  383 WNPngkhSTNFVSRYDPRFNSWIQLPPMQERRASFYACRLDKHLYVIGGRNETGYLSSVECYNLETNEWRYVSSLPQPLA 462
Cdd:PHA02713 315 NNP----SLNKVYKINIENKIHVELPPMIKNRCRFSLAVIDDTIYAIGGQNGTNVERTIECYTMGDDKWKMLPDMPIALS 390

                        490
                 ....*....|....*.
gi 55741643  463 AHAGAVHNGKIYISGG 478
Cdd:PHA02713 391 SYGMCVLDQYIYIIGG 406
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-185 8.67e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 65.54  E-value: 8.67e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  14 SHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHpplgggvggqdglgapkdqqqppqqqps 93
Cdd:cd18242   3 SHAKSILNTMNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFTSE---------------------------- 54

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  94 qqqqpppqeepgtpssspddkllTSPRAINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLC 173
Cdd:cd18242  55 -----------------------MSEKGKSEVELQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQAC 111

                       170
                ....*....|..
gi 55741643 174 VQFLNDQISVQN 185
Cdd:cd18242 112 CEFLESQLDPSN 123
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-63 9.71e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 66.17  E-value: 9.71e-13
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 55741643  13 PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFS 63
Cdd:cd18267  21 SSYADSVLTHLNLLRQQRLFTDVLLHAGNRSFPCHRAVLAACSRYFEAMFS 71
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-185 1.11e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 65.62  E-value: 1.11e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  12 DPSHSDNLLHGLNLLWRKQLFCDVTL--------TAQGQQFHCHKAVLASCSQYFRSLFSshpplgggvggqdglgapkd 83
Cdd:cd18273   6 DAAHARALLAQLKSFYDARLLTDVTIevngpgsgPGSGRLFPCNRNVLAAASPYFKSMFT-------------------- 65

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  84 qqqppqqqpsqqqqpppqeepGTPSSSPDDKlltsprainnLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKI 163
Cdd:cd18273  66 ---------------------GGLYESKQET----------VTIHDVDSESMALIIDYCYTGRVTLSEANVQRLYAAANM 114

                       170       180
                ....*....|....*....|..
gi 55741643 164 LHIPQVTKLCVQFLNDQISVQN 185
Cdd:cd18273 115 LQLEYVREACASFLARRLDLSN 136
BTB_POZ_KLHL9_13 cd18239
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-185 1.28e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349548 [Multi-domain]  Cd Length: 128  Bit Score: 65.21  E-value: 1.28e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  15 HSDNLLHGLNLLWRKQLFCDVTLTA--QGQQFHCHKAVLASCSQYFRSLFSShpplgggvggqdglgapkdqqqppqqqp 92
Cdd:cd18239   6 HSSVVLQGFDQLRGEGLLCDVTLVPgdGDETFPVHRAMMASASDYFKAMFTG---------------------------- 57

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  93 sqqqqpppqeepgtpsSSPDDKLltspRAINnlvLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKL 172
Cdd:cd18239  58 ----------------GMKEQEL----MCIK---LHGVSKIGLKNIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDF 114

                       170
                ....*....|...
gi 55741643 173 CVQFLNDQISVQN 185
Cdd:cd18239 115 CKVLLISGVTLEN 127
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-63 1.86e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 64.65  E-value: 1.86e-12
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 55741643  13 PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFS 63
Cdd:cd18254   3 PSHPDCVLTHLNTLRKQCMFTDVTLWAGNRSFPCHRAVLAACSRYFEAMFS 53
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-185 2.23e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 64.46  E-value: 2.23e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  12 DPSHSDNLLHGLNLLWRKQLFCDVTL-TAQGQQFHCHKAVLASCSQYFRSLFSShpplgggvggqdglgapkdqqqppqq 90
Cdd:cd18252   1 DSSHPADFLDAFRTFYLDGLFTDITLqCASGQIFHCHKAALAACSSYFKVMFTA-------------------------- 54

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  91 qpsqqqqpppqeepgtpssspDDKlltsPRAINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVT 170
Cdd:cd18252  55 ---------------------DMK----EKSNNVIKLSGIDHDILEALVNYVYTSQICITERNVQSLLEAADLLQFISVK 109

                       170
                ....*....|....*
gi 55741643 171 KLCVQFLNDQISVQN 185
Cdd:cd18252 110 KACEQFLVRHLDIDN 124
BACK_KLHL31_KBTBD1 cd18470
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also ...
 181-269 2.35e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also termed BTB and kelch domain-containing protein 6, or Kelch repeat and BTB domain-containing protein 1, or Kelch-like protein KLHL, is a transcriptional repressor in MAPK/JNK signaling pathway that regulates cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).


Pssm-ID: 350545  Cd Length: 98  Bit Score: 63.36  E-value: 2.35e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643 181 ISVQNYKQVCKIAALHGLEETKKLANKYL---------VEDVLLLNFEEMRALL--DSLPPPveSELALFQMSVLWLEHD 249
Cdd:cd18470   1 INVENCMYVVNIAETYGLKNTKEAAQKFIrdnfiefseTDQFLKLTFEQINEFLidDDLQLP--SEITAFQIAMKWLDFD 78

                        90       100
                ....*....|....*....|
gi 55741643 250 rETRMQYAPDLMKRLRFALI 269
Cdd:cd18470  79 -QKRVKYAADLLSNIRFGTI 97
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-185 5.79e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 63.28  E-value: 5.79e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSShpplgggvggqdglgapkdqqqppqqqpsq 94
Cdd:cd18237   4 LLADFMGVMNNMRKQKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTS------------------------------ 53

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  95 qqqpppqeepgtpssspddKLLTSPRAinNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCV 174
Cdd:cd18237  54 -------------------NMTESKSS--EVELKDAEPDIIELLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCV 112

                       170
                ....*....|.
gi 55741643 175 QFLNDQISVQN 185
Cdd:cd18237 113 DFLKEQLDASN 123
BACK_KLHL34 cd18473
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 34 (KLHL34); KLHL34 belongs ...
 192-274 9.06e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 34 (KLHL34); KLHL34 belongs to the KLHL family. Its function remains unclear. The methylation status of KLHL34 cg14232291 may be a predictive candidate of sensitivity to preoperative chemoradiation therapy.


Pssm-ID: 350548  Cd Length: 106  Bit Score: 62.06  E-value: 9.06e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643 192 IAALHGLEETKKLANKYLVED-------------VLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDrETRMQYAP 258
Cdd:cd18473  12 IAARFGLPDALKAAEKYIISNlwrllasdaddagLLELNLESLQAVLEADDIPRVKESRLLTLVLEWLNQD-ESRLAYAN 90

                        90
                ....*....|....*.
gi 55741643 259 DLMKRLRFALIPAPEL 274
Cdd:cd18473  91 ALLSRIRYGLVPVEEL 106
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 413-458 9.07e-12

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 59.93  E-value: 9.07e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 55741643   413 RRASFYACRLDKHLYVIGGRNETGYLSSVECYNLETNEWRYVSSLP 458
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-185 1.01e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 62.70  E-value: 1.01e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  12 DPSHSDNLLHGLNLLWRKQLFCDVTLTA-QGQQFHCHKAVLASCSQYFRSLFSSHPplgggvggqdglgapkdqqqppqq 90
Cdd:cd18274   2 DPLHACSILQQLKAMYDEGQLTDIVVEVdHGKTFSCHRNVLAAISPYFRSMFTSGL------------------------ 57

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  91 qpsqqqqpppqeepgTPSSSPDDKLLtsprainnlvlqGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVT 170
Cdd:cd18274  58 ---------------TESTQKEVRIV------------GVEAESMHLVLDYAYTSRVTLTEANVQALFTAASIFQIPSLQ 110

                       170
                ....*....|....*
gi 55741643 171 KLCVQFLNDQISVQN 185
Cdd:cd18274 111 DQCAQFMISRLDPQN 125
BTB_POZ_KLHL15 cd18244
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 4-189 1.65e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349553 [Multi-domain]  Cd Length: 137  Bit Score: 62.28  E-value: 1.65e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643   4 SGDRTSTFDPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHpplgggvggqdglgapkd 83
Cdd:cd18244   2 AGDVEVYNSSIHDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTAD------------------ 63

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  84 qqqppqqqpsqqqqpppqeepgtpssspddkllTSPRAINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKI 163
Cdd:cd18244  64 ---------------------------------MRERDQDKIHLKGLTATGFSHVLQFMYYGTIELSMLTVHEILQAAMY 110

                       170       180
                ....*....|....*....|....*.
gi 55741643 164 LHIPQVTKLCVQFLNDQISVQNYKQV 189
Cdd:cd18244 111 VQLTEVVKFCCSFLLAKICLDNCAEI 136
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-62 1.72e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 61.77  E-value: 1.72e-11
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 55741643  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLF 62
Cdd:cd18253   1 HSESILQVFNEFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMF 48
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-177 2.31e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 61.11  E-value: 2.31e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  30 QLFCDVT--LTAQGQQFHCHKAVLASCSQYFRSLFSSHPPlgggvggqdglgapkdqqqppqqqpsqqqqpppqeepGTP 107
Cdd:cd18294  12 PEFSDVKflVGPERQEIFAHKCILAARCEVFRAMFLTGPQ-------------------------------------KES 54

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643 108 SSSPddklltsprainnLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFL 177
Cdd:cd18294  55 TQSP-------------LVLSDIEPEVFRAVLEFIYTNCVTLSNHTVIEVLAAAVEYGLDELRKLCERFI 111
BTB_POZ_BACH2 cd18278
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-177 2.43e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349587 [Multi-domain]  Cd Length: 124  Bit Score: 61.50  E-value: 2.43e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHpplgggvggqdglgapkdqqqppqqqpsq 94
Cdd:cd18278  14 HCTNILLCLNDQRKQDILCDVTLIVEGKEFRAHRAVLAACSEYFLQALVGQ----------------------------- 64

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  95 qqqpppqeepgtpssSPDDKLLTSPRAInnlvlqgcSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCV 174
Cdd:cd18278  65 ---------------TENDLVVSLPEEV--------TARGFGPLLQFAYTAKLLLSRENIQEVIRCAEFLRMHNLEDSCF 121


                ...
gi 55741643 175 QFL 177
Cdd:cd18278 122 RFL 124
BTB_POZ_BACH1 cd18277
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-177 5.51e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349586 [Multi-domain]  Cd Length: 120  Bit Score: 60.08  E-value: 5.51e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHpplgggvggqdglgapkdqqqppqqqpsq 94
Cdd:cd18277  10 HSTNVLLSLNDQRKKDVLCDVTILVEGQRFRAHRSVLAACSSYFHSRIVGQ----------------------------- 60

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  95 qqqpppqeepgtpssSPDDKLLTSPRAInnlvlqgcSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCV 174
Cdd:cd18277  61 ---------------ADAELNITLPEEV--------TVKGFEPLIQFAYTAKLILSKDNVDEVCKCVEFLSVHNIEESCF 117


                ...
gi 55741643 175 QFL 177
Cdd:cd18277 118 QFL 120
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
303-445 8.87e-11

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 62.87  E-value: 8.87e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643 303 MPFRqhcRQSLASRIRSNKKmLLLVGGlppgpdrlpsnlvQYYDDEKKTWKILTIMPYNSAHHCVVEVENFLFVLGGEDQ 382
Cdd:COG3055 155 LPTP---RDHLAAAVLPDGK-ILVIGG-------------RNGSGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESG 217

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 55741643 383 WNPNgkhstnfVSRYDPRFNSWIQLPPMQERRASFYACRLDKHLYVIGGRNETG----YLSSVECYN 445
Cdd:COG3055 218 FSDE-------VEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGGETKPGvrtpLVTSAEVYD 277
BTB_POZ_ZBTB24_ZNF450 cd18212
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-179 1.11e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349521 [Multi-domain]  Cd Length: 118  Bit Score: 59.04  E-value: 1.11e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  14 SHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSshpplgggvggqdglgapkdqqqppqqqps 93
Cdd:cd18212   5 THKDTVLTNFEEQRKKDFLCDITLIVENVQFRAHKALLAASSEYFSMMFA------------------------------ 54

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  94 qqqqpppqeEPGTPSSSPddklltsprainnLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLC 173
Cdd:cd18212  55 ---------DEGEVGQSI-------------YMLEGMVAETFGALLEFIYTGCLQVGEKSLEQILATAQFLKVNDLVKAY 112


                ....*.
gi 55741643 174 VQFLND 179
Cdd:cd18212 113 SDYQNN 118
BTB_POZ_ZBTB11 cd18202
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-65 1.86e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349511 [Multi-domain]  Cd Length: 118  Bit Score: 58.71  E-value: 1.86e-10
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 55741643  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLF------SSH 65
Cdd:cd18202   2 HGQTVLDQLNQQRLNNQFCDVTLLIEGEEYKAHKSVLAANSEYFRELFiekgavSSH 58
BTB_POZ_ZBTB38_CIBZ cd18223
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-65 2.42e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349532 [Multi-domain]  Cd Length: 114  Bit Score: 58.26  E-value: 2.42e-10
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 55741643  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSH 65
Cdd:cd18223   1 HSDTVLSCLNEQRIQGILCDVTIVVEDTKFKAHKNVLAASSLYFKNAFSSQ 51
BACK_KLHL12 cd18452
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also ...
 193-304 2.75e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also termed CUL3-interacting protein 1 (C3IP1), or DKIR, is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.


Pssm-ID: 350527 [Multi-domain]  Cd Length: 136  Bit Score: 58.56  E-value: 2.75e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643 193 AALHGLEETKKLANKYLV---------EDVLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMKR 263
Cdd:cd18452  13 AETHNCVDLMQAAEVFSQkhfpevvqhEEFMLLSQEEVEKLIKSDEIQVDSEEPVFEAVLNWVKHDKEEREDYLPELLQY 92

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 55741643 264 LRFALIPAPELVERVQSVDFMRTDPVCQKLLLDAMNYHLMP 304
Cdd:cd18452  93 VRLPLLSPRYITDVVDAEPLIRCSLECRDLVDEAKKFHLRP 133
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-185 3.32e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 58.19  E-value: 3.32e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  19 LLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSShpplgggvggqdglgapkdqqqppqqqpsqqqqp 98
Cdd:cd18269  14 LQDGLKDLLDENKFVDCVLKIGDKEFPCHRLVLAACSPYFRAMFLS---------------------------------- 59

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  99 ppqeepgtpSSSPDDKlltspraiNNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLN 178
Cdd:cd18269  60 ---------DLEESKK--------KEVVLEDVDPDVMGMILKYLYTSEIDLNDQNVQDIFALASRFQIPSIFTVCVSYLQ 122


                ....*..
gi 55741643 179 DQISVQN 185
Cdd:cd18269 123 KRLSLSN 129
BTB_POZ_ZBTB4 cd18195
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-81 3.56e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349504 [Multi-domain]  Cd Length: 124  Bit Score: 57.98  E-value: 3.56e-10
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 55741643  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPPLGGGVGGQDGLGAP 81
Cdd:cd18195   1 HAGALLLQLNEQRLRGLFCDVTLIAGDTKFRAHRSVLAASSPYFRELLSSPLPLGAAAVAAAPGATQ 67
BTB_POZ_KLHL2_Mayven cd18338
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-181 4.31e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349647 [Multi-domain]  Cd Length: 121  Bit Score: 57.77  E-value: 4.31e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  12 DPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHpplgggvggqdglgapkdqqqppqqq 91
Cdd:cd18338   1 NPRHMKKAFKVMNELRSQNLLCDVTIVAEDVEIAAHRVVLAACSPYFHAMFTGE-------------------------- 54

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  92 psqqqqpppqeepgtpssspddklLTSPRAiNNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTK 171
Cdd:cd18338  55 ------------------------MSESRA-KRVRIKEVDGWTLKMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKK 109

                       170
                ....*....|
gi 55741643 172 LCVQFLNDQI 181
Cdd:cd18338 110 TCCEFLESQL 119
BTB_POZ_KLHL41_KBTBD10 cd18341
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-185 5.35e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349650 [Multi-domain]  Cd Length: 133  Bit Score: 57.55  E-value: 5.35e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  19 LLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHpplgggvggqdglgapkdqqqppqqqpsqqqqp 98
Cdd:cd18341  14 LQDGLKELLDENKFVDCTLKAGDKSLPCHRLILAACSPYFREYFLSE--------------------------------- 60

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  99 pPQEEPGtpssspddklltspraiNNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLN 178
Cdd:cd18341  61 -ESEEKK-----------------KEVVLDNVDPNIMDMILKYLYSAEIDLNDGNVQDIFALASRFQIPSVFTVCVTYLQ 122


                ....*..
gi 55741643 179 DQISVQN 185
Cdd:cd18341 123 KRLSPAN 129
BTB_POZ_ZBTB28_BCL6B cd18332
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-177 5.81e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349641 [Multi-domain]  Cd Length: 114  Bit Score: 57.17  E-value: 5.81e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSshpplgggvggqdglgapkdqqqppqqqpsq 94
Cdd:cd18332   2 HSSDVLLNLNELRKRDILTDVTLLVGGTPLRAHKAVLIACSGFFYSIFS------------------------------- 50

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  95 qqqpppqEEPGTPSSSpddklLTSPrainnlvlQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCV 174
Cdd:cd18332  51 -------GRVGEGVSV-----LTLP--------SGLEARGFQLLLDFMYTSRLPLTPRTVPAVLAAATYLQMEHVVETCR 110


                ...
gi 55741643 175 QFL 177
Cdd:cd18332 111 RFI 113
BTB_POZ_BTBD14B_NAC1 cd18290
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-67 5.96e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349599 [Multi-domain]  Cd Length: 123  Bit Score: 57.35  E-value: 5.96e-10
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 55741643  13 PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPP 67
Cdd:cd18290   8 PNFGNSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSSRS 62
PLN02153 PLN02153
epithiospecifier protein
 359-611 6.18e-10

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 61.16  E-value: 6.18e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  359 PYNSAHHCVVEVENFLFVLGGEdqWNPNgKHSTNFVSRYDPRFNSWIQLPPMQER-RASFYACRL---DKHLYVIGGRNE 434
Cdd:PLN02153  20 PGPRCSHGIAVVGDKLYSFGGE--LKPN-EHIDKDLYVFDFNTHTWSIAPANGDVpRISCLGVRMvavGTKLYIFGGRDE 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  435 TGYLSSVECYNLETNEWRYVSSL-----PQPLAAHAGAVHNGKIYISGGVHNGEYvpwlycydpvmdvwarkqdMNTKRA 509
Cdd:PLN02153  97 KREFSDFYSYDTVKNEWTFLTKLdeeggPEARTFHSMASDENHVYVFGGVSKGGL-------------------MKTPER 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  510 IHTlavmndrlyaiggnhlkgfshldvmlVECYDPKGDQWNILQTP--ILEGRSGPGCAVLDDSIYLVGGYSWSM----- 582
Cdd:PLN02153 158 FRT--------------------------IEAYNIADGKWVQLPDPgeNFEKRGGAGFAVVQGKIWVVYGFATSIlpggk 211

                        250       260       270
                 ....*....|....*....|....*....|
gi 55741643  583 GAYKSSTICYC-PEKGTWTELEGDVAEPLA 611
Cdd:PLN02153 212 SDYESNAVQFFdPASGKWTEVETTGAKPSA 241
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 32-166 7.37e-10

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 55.63  E-value: 7.37e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  32 FCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPplgggvggqdglgapkdqqqppqqqpsqqqqpppqeepgtPSSSP 111
Cdd:cd18315   1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKETP----------------------------------------PDEHP 40

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 55741643 112 DdklltsprainnLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHI 166
Cdd:cd18315  41 V------------IILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAELLQI 83
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-185 8.49e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 57.10  E-value: 8.49e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  11 FDPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSShpplgggvggqdglgapkdqqqppqq 90
Cdd:cd18268   2 KDQDLSSELLRQLNSLRQERILTDVILCTGDKEIPCHRNVLASSSPYFRAMFCN-------------------------- 55

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  91 qpsqqqqpppqeepgtpssspDDKLLTSPRainnLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVT 170
Cdd:cd18268  56 ---------------------NFRESSQAK----VDLKGIDSDVLDQIVDYVYTGEILITRDNVLPLMEAASMLQYPKLF 110

                       170
                ....*....|....*
gi 55741643 171 KLCVQFLNDQISVQN 185
Cdd:cd18268 111 EACSLYLQDQLTPEN 125
BTB2_POZ_KLHL33 cd18263
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 20-64 1.02e-09

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349572 [Multi-domain]  Cd Length: 118  Bit Score: 56.36  E-value: 1.02e-09
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 55741643  20 LHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSS 64
Cdd:cd18263   1 LQSIEGLWEKGVGCDVQLEADGSIFRVHRVILAAGSDYFRAMFTS 45
BACK_KLHL2_like cd18445
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This ...
 193-279 1.51e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.


Pssm-ID: 350520 [Multi-domain]  Cd Length: 114  Bit Score: 55.70  E-value: 1.51e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643 193 AALHGLEETKKLANKYLV---------EDVLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMKR 263
Cdd:cd18445  13 ADLHSCTDLLKYAQTYTEqhfsevvkgEEFLLLSKEQVCELISSDDLTVPSEEKVFEAVMSWVNHDPENRKEHLAELLEH 92

                        90
                ....*....|....*.
gi 55741643 264 LRFALIPAPELVERVQ 279
Cdd:cd18445  93 VRLPLLSPEYLVQRVE 108
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-177 1.77e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 55.71  E-value: 1.77e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSShpplgggvggqdglgapkdqqqppqqqpsq 94
Cdd:cd18287   5 HVHFLSEDIGALFLNEEYSDVTFVVEEKRFPAHRVILAARSEYFRALLYG------------------------------ 54

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  95 qqqpppqeepGTPSSSPDDklltsprainnLVLQGCSSIGLRLVLEYLYTANVTLSL---DTVEEVLSVSKILHIPQVTK 171
Cdd:cd18287  55 ----------GMRESQQSE-----------IELKDTNAEAFKALLKYIYTGRLTLTDlkeDVLLDVLGLAHQYGFEELEA 113


                ....*.
gi 55741643 172 LCVQFL 177
Cdd:cd18287 114 AISDYL 119
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-184 2.08e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 55.74  E-value: 2.08e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  15 HSDNLLHGLNLlWRKQ--LFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHpplgggvggqdglgapkdqqqppqqqp 92
Cdd:cd18207   9 HSADMLHNLNQ-QRKSggRFCDVLLRVGEESFPAHRAVLAACSEYFESVFSAQ--------------------------- 60

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  93 sqqqqpppQEEPGTPssspddklltspraiNNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKL 172
Cdd:cd18207  61 --------EGDGGTP---------------RELEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIDI 117

                       170
                ....*....|..
gi 55741643 173 CVQFLNdQISVQ 184
Cdd:cd18207 118 CQEVIK-QSNVQ 128
BTB_POZ_ZBTB48_TZAP_KR3 cd18232
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-176 3.03e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349541 [Multi-domain]  Cd Length: 108  Bit Score: 54.76  E-value: 3.03e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFsshpplgggvggqdglgapkdqqqppqqqpsq 94
Cdd:cd18232   1 HSVKVLQALNKQREEGQYCDATLDVGGRVFKAHWSVLACCSHFFQSLY-------------------------------- 48

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  95 qqqpppqeepGTPSSSpddklltsprainNLVL-QGCSSIgLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLC 173
Cdd:cd18232  49 ----------GDGTSG-------------SVVLpESFAEV-FGLLLDFFYTGELALTRENRDRVLLAAKELRVPEAVELC 104


                ...
gi 55741643 174 VQF 176
Cdd:cd18232 105 QRF 107
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-185 3.60e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 55.23  E-value: 3.60e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  19 LLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHpplgggvggqdglgapkdqqqppqqqpsqqqqp 98
Cdd:cd18340  14 LQDGLKDLLDHNKFVDCVLKIKEKEFPCHRLVLAACSPYFRAMFLSD--------------------------------- 60

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  99 ppqeepgtpssspddkllTSPRAINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLN 178
Cdd:cd18340  61 ------------------LEESKKREIVLEDVDPDVMGKILHYIYTSEIEITEQNVQDIFAAANMFQIPSIFTVCVSFLQ 122


                ....*..
gi 55741643 179 DQISVQN 185
Cdd:cd18340 123 KRLCLSN 129
BTB_POZ_ZBTB10 cd18201
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-182 3.73e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349510 [Multi-domain]  Cd Length: 122  Bit Score: 54.96  E-value: 3.73e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  14 SHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSShpplgggvggqdglgapkdqqqppqqqps 93
Cdd:cd18201   3 SYCYQLLQELNEQRKKGILCDVNIVVSGKVFRAHKNILVAGSRFFKTLYCF----------------------------- 53

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  94 qqqqpppqeepgTPSSSPDDKLLTSpraINNLVLQGCSSIglrlvLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLC 173
Cdd:cd18201  54 ------------TNKESCDQTTVTH---LDVVAVQGFSVI-----LDFMYSGNLVLTSQNAIEVMSVASYLQMTEVVQSC 113


                ....*....
gi 55741643 174 VQFLNDQIS 182
Cdd:cd18201 114 RNFIKDALN 122
BTB_POZ_KLHL3 cd18339
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-181 4.44e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349648 [Multi-domain]  Cd Length: 121  Bit Score: 54.73  E-value: 4.44e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  12 DPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSshpplgggvggqdglgapkdqqqppqqq 91
Cdd:cd18339   1 NPAHMKKAFKVMNELRSKQLLCDVTIVAEDVEIEAHRVVLAACSPYFCAMFT---------------------------- 52

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  92 psqqqqpppqeepGTPSSSPDDKLltsprAINNLVLQgcssiGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTK 171
Cdd:cd18339  53 -------------GDMSESKAKKI-----EIKDVDGQ-----TLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQ 109

                       170
                ....*....|
gi 55741643 172 LCVQFLNDQI 181
Cdd:cd18339 110 NCCDFLQSQL 119
BTB_POZ_BACH cd18955
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 33-177 4.54e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349736 [Multi-domain]  Cd Length: 94  Bit Score: 54.01  E-value: 4.54e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  33 CDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHpplgggvggqdglgapkdqqqppqqqpsqqqqpppqeepgtpssSPD 112
Cdd:cd18955   2 CDVTIVVEDQRFRAHRAVLAACSDYFLSRVVGQ--------------------------------------------TDG 37

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 55741643 113 DKLLTSPRAInnlvlqgcSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFL 177
Cdd:cd18955  38 DLVITLPEEV--------TVKGFEPLLQFAYTAKLLLSKENVLEVCRCAEFLGVHNIEKACFDFL 94
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-181 5.95e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 54.31  E-value: 5.95e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  14 SHSDNLLHGLNLLWRKQLFCDVTLTAQGQ----QFHCHKAVLASCSQYFRSLFSShpplgggvggqdglgapkdqqqppq 89
Cdd:cd18248   3 DHTKEAFQIMNELRLSQQLCDVTLKVKYQdpkeEFMAHKVVLASSSPYFKAMFTS------------------------- 57

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  90 qqpsqqqqppPQEEpgtpssspddklltspRAINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQV 169
Cdd:cd18248  58 ----------GLRE----------------CGMEVVPIEGVHPCVMSRLIEFAYTASISVGEKCVLHVLPGAVMYQMDSV 111

                       170
                ....*....|..
gi 55741643 170 TKLCVQFLNDQI 181
Cdd:cd18248 112 VKACCDFLEQQL 123
BTB_POZ_BTBD18 cd18293
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 26-175 8.68e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349602 [Multi-domain]  Cd Length: 120  Bit Score: 54.03  E-value: 8.68e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  26 LWRKQ---LFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPPlgggvggqdglgapkdqqqppqqqpsqqqqpppqe 102
Cdd:cd18293   6 LHRQQnsgVFCDVLLQAEGESVPAHCCVLSACSPYLTERLSSEPP----------------------------------- 50

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 55741643 103 epgtPSSSpddKLLtsprainnLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQ 175
Cdd:cd18293  51 ----PAGQ---KVV--------LELQGLKAHTLLKLVDFLYTSELEVSSEEAQDVLAAARRLQISELESLCLE 108
PLN02193 PLN02193
nitrile-specifier protein
 365-577 1.08e-08

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 58.04  E-value: 1.08e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  365 HCVVEVENFLFVLGGEDQWN-PNGKHSTNFvsryDPRFNSWIQLPPMQE-RRASFYACRL---DKHLYVIGGRNETGYLS 439
Cdd:PLN02193 169 HGIAQVGNKIYSFGGEFTPNqPIDKHLYVF----DLETRTWSISPATGDvPHLSCLGVRMvsiGSTLYVFGGRDASRQYN 244

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  440 SVECYNLETNEWRYVSSL---PQPLAAHAGAVHNGKIYISGGVHNGEYVPWLYCYDPVMDVW---ARKQDMNTKRAIHTL 513
Cdd:PLN02193 245 GFYSFDTTTNEWKLLTPVeegPTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKWfhcSTPGDSFSIRGGAGL 324

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 55741643  514 AVMNDRLYAIggnhlKGFSHLDVMLVECYDPKGDQWNILQT----PilEGRSGPGCAVLDDSIYLVGG 577
Cdd:PLN02193 325 EVVQGKVWVV-----YGFNGCEVDDVHYYDPVQDKWTQVETfgvrP--SERSVFASAAVGKHIVIFGG 385
BTB_POZ_BTBD14A_NAC2 cd18289
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-63 1.55e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349598 [Multi-domain]  Cd Length: 131  Bit Score: 53.50  E-value: 1.55e-08
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 55741643  13 PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFS 63
Cdd:cd18289  10 PNFGNTVLGCLNEQRLMGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFS 60
BTB_POZ_ZBTB33_KAISO cd18219
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-63 1.67e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349528 [Multi-domain]  Cd Length: 106  Bit Score: 52.53  E-value: 1.67e-08
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 55741643  12 DPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFS 63
Cdd:cd18219   1 DTQYSGSLLKSLNEQRGHGLFCDVTVIVEDRKFRAHKNILSASSTYFHQLFS 52
BACK_KLHL9_13 cd18449
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 ...
 181-267 1.92e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 and KLHL13 (also termed BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.


Pssm-ID: 350524 [Multi-domain]  Cd Length: 95  Bit Score: 52.04  E-value: 1.92e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643 181 ISVQNYKQVCKIAALHGLEETKKLANKYL---------VEDVLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDrE 251
Cdd:cd18449   1 VSLENCVEIGRIANTYHLTEVDKYVNDFIlknfpallsTGDFVKLPFERLAFVLSSNSLKGCTELELFKAACRWLRHE-D 79

                        90
                ....*....|....*.
gi 55741643 252 TRMQYAPDLMKRLRFA 267
Cdd:cd18449  80 DRMQFAAKLMENIRFP 95
PHA02713 PHA02713
hypothetical protein; Provisional
 433-577 2.36e-08

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 56.94  E-value: 2.36e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  433 NETGYLSSVEC---YNLETNEWRYVSSLPQPLAAHAGAVHNGKIYISGGVH-NGEYVPWLYCYDPVMDVWARKQDMNTKR 508
Cdd:PHA02713 263 HDTKYNVCNPCilvYNINTMEYSVISTIPNHIINYASAIVDNEIIIAGGYNfNNPSLNKVYKINIENKIHVELPPMIKNR 342

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  509 AIHTLAVMNDRLYAIGGNHLKGFSHldvmLVECYDPKGDQWNIL-QTPIleGRSGPGCAVLDDSIYLVGG 577
Cdd:PHA02713 343 CRFSLAVIDDTIYAIGGQNGTNVER----TIECYTMGDDKWKMLpDMPI--ALSSYGMCVLDQYIYIIGG 406
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 30-173 2.52e-08

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 52.68  E-value: 2.52e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  30 QLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHpplgggvggqdglgapkdqqqppqqqpsqqqqppPQEEPGTPSS 109
Cdd:cd18296  15 LSFPDVCFQVEGHRFPCHKAFFCGRSDYFKALLRDH----------------------------------FAESEENNGS 60

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 55741643 110 SPddklltsprainNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLC 173
Cdd:cd18296  61 IP------------VVTLHDVSPEVFAIVLYYIYTDDTDLPPENAYDVLYVADMYLLPGLKRLC 112
BTB_POZ_ZBTB49 cd18233
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-177 3.10e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349542 [Multi-domain]  Cd Length: 112  Bit Score: 52.20  E-value: 3.10e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSShpplgggvggqdglgapkdqqqppqqqpsq 94
Cdd:cd18233   1 HSCHLLQQLHEQRIQGLLCDCMLVVKGVCFKAHKNVLAAFSQYFRSLFQN------------------------------ 50

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  95 qqqpppqeepgTPSSSPDdklltspraINNLVLQGCSSIGlrLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCV 174
Cdd:cd18233  51 -----------SSSQKND---------VFHLDIKNVGGIG--QILDFMYTSHLDLNQDNVQVMLDIAQCLQVQNVLNMCY 108


                ...
gi 55741643 175 QFL 177
Cdd:cd18233 109 TFL 111
BTB_POZ_ZBTB6 cd18197
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-62 4.24e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 6 (ZBTB6); ZBTB6, also called zinc finger protein 482 (ZNF482) or zinc finger protein with interaction domain, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349506 [Multi-domain]  Cd Length: 116  Bit Score: 51.79  E-value: 4.24e-08
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 55741643  14 SHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLF 62
Cdd:cd18197   7 QQGDAVLQKMNLLRQQNLFCDVSIYINDTEFHGHKVILAACSTFMRDQF 55
BTB_POZ_ZBTB12 cd18203
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-66 4.44e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 12 (ZBTB12); ZBTB12, also called protein G10, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349512 [Multi-domain]  Cd Length: 122  Bit Score: 51.80  E-value: 4.44e-08
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 55741643  13 PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHP 66
Cdd:cd18203   6 PGHEAATLRNMNQLRSEERFCDVTIVADSLKFRGHKVVLAACSPFLRDQFLLNP 59
BTB_POZ_KBTBD12 cd18276
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-185 4.66e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349585 [Multi-domain]  Cd Length: 127  Bit Score: 52.11  E-value: 4.66e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSShpplgggvggqdglgapkdqqqppqqqpsq 94
Cdd:cd18276   4 HSLTLLDQLNRMKELAELTDVVLVAEGEKFPCHRLVLAAFSPYFKAMFTC------------------------------ 53

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  95 qqqpppqeepgtpssspddKLLTSPRaiNNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCV 174
Cdd:cd18276  54 -------------------GLMECSQ--REVVLHDITAESVSIILNYMYSSDLHLTNSNVQGVATAAFFLQMEDIFSVCQ 112

                       170
                ....*....|.
gi 55741643 175 QFLNDQISVQN 185
Cdd:cd18276 113 KYMMDHMDASN 123
BTB_POZ_KLHL6 cd18236
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-185 1.24e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349545 [Multi-domain]  Cd Length: 129  Bit Score: 51.00  E-value: 1.24e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  19 LLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHpplgggvggqdglgapkdqqqppqqqpsqqqQP 98
Cdd:cd18236  11 LQNGLENLRLENSLTDVILCVDSQEFSCHRVVLAAASNYFRAMFCND-------------------------------LK 59

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  99 PPQEEpgtpssspddklltsprainNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLN 178
Cdd:cd18236  60 EKYEE--------------------KIIIKGVDAETMQILLDYTYTSKVLITKQNVQRVLEAASLFQFLRMVDACASFLT 119


                ....*..
gi 55741643 179 DQISVQN 185
Cdd:cd18236 120 EALHPEN 126
BTB_POZ_ZBTB3 cd18323
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-173 1.40e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349632 [Multi-domain]  Cd Length: 128  Bit Score: 50.60  E-value: 1.40e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  13 PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPPlgggvggqdglgaPKDQQQPpqqqp 92
Cdd:cd18323   4 PDHSRHLLQSLREQRHQGFLCDCTVLVGSTQFLAHRAVLASCSPFFHMFYKEQLD-------------KRDLVCI----- 65

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  93 sqqqqpppqeepgtpssspDDKLLTSPrainnlvlqgcssiGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKL 172
Cdd:cd18323  66 -------------------NNEIVTAP--------------AFSLLLEFMYEGRLSFNDTPVEDVLAAASYLHMNDIVKV 112


                .
gi 55741643 173 C 173
Cdd:cd18323 113 C 113
BTB_POZ_ZBTB18_2-like cd18325
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-180 1.68e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349634 [Multi-domain]  Cd Length: 128  Bit Score: 50.42  E-value: 1.68e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  13 PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSshpplgggvggqdglgapkdqqqppqqqp 92
Cdd:cd18325   4 PDHSRQLLQCLSQQRHQGFLCDCTVLVGEAQFRAHRAVLASCSMYFHLFYR----------------------------- 54

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  93 sqqqqpppqeepgtpssspdDKLltSPRAINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKL 172
Cdd:cd18325  55 --------------------DQL--DKRDIVHLNSDIVTAPAFSLLLEFMYEGKLEFSSLPVEDVLAAASYLHMYDIVKV 112


                ....*...
gi 55741643 173 CVQFLNDQ 180
Cdd:cd18325 113 CKGKLKDK 120
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 460-505 1.98e-07

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 47.61  E-value: 1.98e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 55741643   460 PLAAHAGAVHNGKIYISGGVHNGEYVPWLYCYDPVMDVWARKQDMN 505
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
BTB_POZ_ZBTB1 cd18192
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-65 2.06e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1); ZBTB1 acts as a transcriptional repressor that represses cAMP-responsive element (CRE)-mediated transcriptional activation. It also has a role in translesion DNA synthesis, and is essential for lymphocyte development. ZBTB1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349501 [Multi-domain]  Cd Length: 114  Bit Score: 49.82  E-value: 2.06e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 55741643  13 PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSH 65
Cdd:cd18192   2 PSHSSYVLQQLNNQREWGFLCDCCIAIDDIYFQAHKAVLAACSSYFRMMFINH 54
BTB_POZ_ZBTB21_ZNF295 cd18209
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-64 2.11e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349518 [Multi-domain]  Cd Length: 112  Bit Score: 49.87  E-value: 2.11e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 55741643  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSS 64
Cdd:cd18209   1 HAISLLSALNEERLKGQLCDVLLIVGDQKFRAHKNVLAASSEYFQSLFTE 50
Kelch_4 pfam13418
Galactose oxidase, central domain;
413-459 2.30e-07

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 47.61  E-value: 2.30e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 55741643   413 RRASFYACRLDKH-LYVIGGRNETG-YLSSVECYNLETNEWRYVSSLPQ 459
Cdd:pfam13418   1 PRAYHTSTSIPDDtIYLFGGEGEDGtLLSDLWVFDLSTNEWTRLGSLPS 49
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-189 3.12e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 49.83  E-value: 3.12e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  14 SHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHpplgggvggqdglgapkdqqqppqqqps 93
Cdd:cd18271   6 CHGQQILSVLQNFREQNAFFDFNIIVKDETIPCHRCVLAACSDFFRAMFEVN---------------------------- 57

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  94 qqqqpppqeepgtpSSSPDDKLLTspraINNLvlqgcSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLC 173
Cdd:cd18271  58 --------------MKERDDGSVT----ISNL-----SPKAVKAFLDYAYTGKAEITDDNVEMFFQMSSFLQVSLLSKAC 114

                       170
                ....*....|....*.
gi 55741643 174 VQFLNDQISVQNYKQV 189
Cdd:cd18271 115 SDFLIKSIDLTNCLQL 130
BTB_POZ_ZBTB35_ZNF131 cd18221
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-62 3.34e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349530 [Multi-domain]  Cd Length: 113  Bit Score: 49.23  E-value: 3.34e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 55741643  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLF 62
Cdd:cd18221   1 HYKVMLDRLNEQRELDQFTDITLIVDGHQFKAHKAVLAACSQFFYKFF 48
BTB_POZ_ZBTB39 cd18224
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-64 3.38e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349533 [Multi-domain]  Cd Length: 123  Bit Score: 49.45  E-value: 3.38e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 55741643  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSS 64
Cdd:cd18224   9 HPNNLLKELNKCRLSETMCDVTIVVGNRSFAAHKAVLACAAGYFQKLFLS 58
PRK14131 PRK14131
N-acetylneuraminate epimerase;
422-577 3.57e-07

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 52.71  E-value: 3.57e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  422 LDKHLYVIGG---RNETG---YLSSVECYNLETNEWRYVSSL-PQPLAAHAGAV-HNGKIYISGGVH----NGEYVpwly 489
Cdd:PRK14131  83 IDGKLYVFGGigkTNSEGspqVFDDVYKYDPKTNSWQKLDTRsPVGLAGHVAVSlHNGKAYITGGVNknifDGYFE---- 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  490 cydpvmDVWARKQDMNTKRAIhTLAVMNDRLYAIggnhlkgFSHLDVMLvecYDPKGDQW-NILQTPILeGRSGPGCAVL 568
Cdd:PRK14131 159 ------DLAAAGKDKTPKDKI-NDAYFDKKPEDY-------FFNKEVLS---YDPSTNQWkNAGESPFL-GTAGSAVVIK 220


                 ....*....
gi 55741643  569 DDSIYLVGG 577
Cdd:PRK14131 221 GNKLWLING 229
BTB_POZ_ZBTB37 cd18222
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-63 4.47e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349531 [Multi-domain]  Cd Length: 123  Bit Score: 49.27  E-value: 4.47e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 55741643  13 PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFS 63
Cdd:cd18222   6 PDFSNSVLSHLNQLRMQGRLCDIVVNVQGQSFRAHKVVLAASSPYFRDHMS 56
PHA02790 PHA02790
Kelch-like protein; Provisional
 364-604 4.64e-07

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 52.74  E-value: 4.64e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  364 HHCV-VEVENFLFVLGGedqWNPNGKHstNFVSRYDPRFNSWIQLPPMQERRASFYACRLDKHLYVIGGRNETgylSSVE 442
Cdd:PHA02790 263 HMCTsTHVGEVVYLIGG---WMNNEIH--NNAIAVNYISNNWIPIPPMNSPRLYASGVPANNKLYVVGGLPNP---TSVE 334

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  443 CYNLETNEWRYVSSLPQPLAAHAGAVHNGKIYISGGvHNGEYVPWLYCYdPVMDVWARKQDMNTKRAIHTLAVMNDRLYA 522
Cdd:PHA02790 335 RWFHGDAAWVNMPSLLKPRCNPAVASINNVIYVIGG-HSETDTTTEYLL-PNHDQWQFGPSTYYPHYKSCALVFGRRLFL 412

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  523 IGGNhlkgfshldvmlVECYDPKGDQWNILQTPILEgRSGPGCAVLDDSIYLVGGYswSMGAYKSSTICYCPEKGTWTEL 602
Cdd:PHA02790 413 VGRN------------AEFYCESSNTWTLIDDPIYP-RDNPELIIVDNKLLLIGGF--YRGSYIDTIEVYNNRTYSWNIW 477


                 ..
gi 55741643  603 EG 604
Cdd:PHA02790 478 DG 479
BTB_POZ_ZBTB27-like cd18215
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-62 4.78e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349524 [Multi-domain]  Cd Length: 113  Bit Score: 48.72  E-value: 4.78e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 55741643  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLF 62
Cdd:cd18215   2 HASDVLLNLNRLRSRDILTDVVLVVGREQFRAHKTVLMACSGLFYSIF 49
BTB_POZ_ZBTB8A_BOZF1 cd18329
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-63 5.00e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349638 [Multi-domain]  Cd Length: 116  Bit Score: 48.67  E-value: 5.00e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 55741643  14 SHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFS 63
Cdd:cd18329   3 SHQSRLLQQLDEQRKQELFCDCSILVEGQVFKAHRNVLFASSGYFKMLLS 52
BTB_POZ_KLHL29_KBTBD9 cd18258
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-185 6.36e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349567 [Multi-domain]  Cd Length: 125  Bit Score: 48.82  E-value: 6.36e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  19 LLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSShpplgggvggqdglgAPKDqqqppqqqpsqqqqp 98
Cdd:cd18258   4 MLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKR---------------SSRD--------------- 53

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  99 ppqeepgtpsSSPDDKLltsprainNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLN 178
Cdd:cd18258  54 ----------SGGGEKL--------ELTMSNINADVLELLLEFVYTGSLIIDSANAKTLLEAANKFQFHTFCKVCVSFLE 115


                ....*..
gi 55741643 179 DQISVQN 185
Cdd:cd18258 116 KQLTASN 122
BTB_POZ_KBTBD4 cd18272
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-189 6.60e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349581 [Multi-domain]  Cd Length: 140  Bit Score: 49.12  E-value: 6.60e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643   8 TSTF-DPSHSDNLLHG-LNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHpplgggvggqdglgapkdqq 85
Cdd:cd18272   6 SYTFtDRSHSSRVAQSiMDLCLEDGLFADVTISVEGKEFQLHRLVLSAQSCFFRSMFTSN-------------------- 65

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  86 qppqqqpsqqqqpppqeepgtpssspddklLTSPRAiNNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILH 165
Cdd:cd18272  66 ------------------------------LKEARN-RVIELKDVSESVFQLLVDYIYHGTVKLRVEELQETYEVADMYQ 114

                       170       180
                ....*....|....*....|....
gi 55741643 166 IPQVTKLCVQFLNDQISVQNYKQV 189
Cdd:cd18272 115 LTALFEECSRFLARTVQVRNCLQV 138
BTB_POZ_ZBTB18_RP58 cd18324
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-184 6.85e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349633 [Multi-domain]  Cd Length: 147  Bit Score: 49.27  E-value: 6.85e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  13 PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFsshpplgggvggqdglgapKDQQqppqqqp 92
Cdd:cd18324   4 PDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHLFY-------------------KDQL------- 57

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  93 sqqqqpppqeepgtpssspdDKlltspRAINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKL 172
Cdd:cd18324  58 --------------------DK-----RDIVHLNSDIVTAPAFALLLEFMYEGKLQFKDLPIEDVLAAASYLHMYDIVKV 112

                       170
                ....*....|..
gi 55741643 173 CVQFLNDQISVQ 184
Cdd:cd18324 113 CKKKLKEKATTE 124
BACK_KLHL18 cd18457
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as ...
 205-278 9.64e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A.


Pssm-ID: 350532 [Multi-domain]  Cd Length: 107  Bit Score: 47.69  E-value: 9.64e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643 205 ANKYL---------VEDVLLLNFEEMRALL--DSLPppVESELALFQMSVLWLEHDRETRMQYAPDLMKRLRFALIPAPE 273
Cdd:cd18457  25 ANKYIqqhfievskSEEFLALSKEEVLEILsrDELN--VKSEEQVFEAALAWVKYDRENREEYLPELLSKVRLPLLRPQF 102


                ....*
gi 55741643 274 LVERV 278
Cdd:cd18457 103 LTDRV 107
BTB_POZ_KLHL22 cd18251
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-177 1.24e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349560 [Multi-domain]  Cd Length: 125  Bit Score: 47.89  E-value: 1.24e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  14 SHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSShpplgggvggqdglgapkdqqqppqqqps 93
Cdd:cd18251   5 AHSQALLDGLVALRDSGILFDVVLVVEGKPIEAHRILLAASCDYFRGMFAG----------------------------- 55

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  94 qQQQPPPQEEpgtpssspddklltsprainnLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLC 173
Cdd:cd18251  56 -GLREMQQTE---------------------VLIHGVSYNAMCKILDFIYTSELELSLDNVQETLTAACQLQIPEVIGFC 113


                ....
gi 55741643 174 VQFL 177
Cdd:cd18251 114 CDFL 117
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 32-185 1.24e-06

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 47.36  E-value: 1.24e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  32 FCDVTLTAQ-GQQFHCHKAVLASCSQYFRSLFSSHpplgggvggqdglgapkdqqqppqqqpsqqqqpppqeepGTPSSS 110
Cdd:cd18302   5 LYDVTIVSEdGKEFPCHKCVLVARLEYFHSMLSSS---------------------------------------WIEASS 45

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643 111 pdDKLLTSPraINNLVLQgcssiglrLVLEYLYT---ANVTLSLDT--VEEVLSVSKILHIPQVTKLCVQFLNDQISVQN 185
Cdd:cd18302  46 --CSALTMP--IPSDILE--------IILDYLYTdeaSAVKESQNVefLCNVLVIADQLLITRLKEICEVALVELLSLKN 113
BTB_POZ_ZBTB29-like cd18216
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-61 1.65e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349525 [Multi-domain]  Cd Length: 118  Bit Score: 47.14  E-value: 1.65e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 55741643  13 PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSL 61
Cdd:cd18216   1 PSHATQLLLQLNNQRTKGFLCDVIIVVENSLFRAHKNVLAASSGYFKSL 49
Kelch smart00612
Kelch domain;
472-518 1.79e-06

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 44.86  E-value: 1.79e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 55741643    472 KIYISGGVHNGEYVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMND 518
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BACK_KLHL1_like cd18444
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; ...
 193-275 1.83e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This subfamily contains Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. Members of this subfamily contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels.


Pssm-ID: 350519 [Multi-domain]  Cd Length: 106  Bit Score: 46.94  E-value: 1.83e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643 193 AALHGLEETKKLANKYLVE---------DVLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMKR 263
Cdd:cd18444  14 ADAQGCTDLLKVAHNYTMEhfmeviqnqEFLLLPAEEVAKLLASDDLNVPSEETIFHALLLWVKHDLPERKKHLAKLLAL 93

                        90
                ....*....|..
gi 55741643 264 LRFALIPaPELV 275
Cdd:cd18444  94 IRLPLLT-PQFL 104
BTB_POZ_ZBTB41 cd18226
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-66 2.00e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349535 [Multi-domain]  Cd Length: 114  Bit Score: 47.10  E-value: 2.00e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 55741643  15 HSDNLLHGLNLLWRKQL-FCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHP 66
Cdd:cd18226   4 YNKNLLKYLNDDRQKQSsFCDLVITVEGKEFSAHKVVVAVGSSYFHACLSKNP 56
BTB_POZ_KLHL20_KLEIP cd18249
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-63 2.09e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349558 [Multi-domain]  Cd Length: 128  Bit Score: 47.45  E-value: 2.09e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 55741643  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFS 63
Cdd:cd18249   6 HPRQTLEAINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFT 54
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-62 2.24e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 47.15  E-value: 2.24e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 55741643  23 LNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLF 62
Cdd:cd18345   9 LGLLFERSAFSDVTLCVGGREFQAHKAILAARSPVFNAMF 48
BTB_POZ_ZBTB3-like cd18194
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-66 2.40e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349503 [Multi-domain]  Cd Length: 128  Bit Score: 47.12  E-value: 2.40e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 55741643  13 PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHP 66
Cdd:cd18194   4 PEHSRQLLQCLREQRSQGFLCDCTVLVGSAQFPAHRAVLASCSMYFHLFYRDRL 57
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 33-185 2.53e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 46.21  E-value: 2.53e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  33 CDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHpplgggvggqdglgapkdqqqppqqqpsqqQQPPPQEEpgtpssspd 112
Cdd:cd18234   2 CDVILIAGDRRIPAHRLVLSAVSDYFAAMFTND------------------------------VREATEEE--------- 42

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 55741643 113 dklltsprainnLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQN 185
Cdd:cd18234  43 ------------IKLKDVDPDALWTLVQYCYTGRLELKEDNVESLLATACLLQLSEVVEACCGFLMKQLHPSN 103
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-64 3.00e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 46.50  E-value: 3.00e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 55741643  23 LNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSS 64
Cdd:cd18247  10 MEEIRRQGKLCDVTLKVGDQKFSAHRIVLAATIPYFHAMFTH 51
Kelch smart00612
Kelch domain;
519-570 3.35e-06

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 44.09  E-value: 3.35e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 55741643    519 RLYAIGGNHlkGFSHLDVmlVECYDPKGDQWNILqTPILEGRSGPGCAVLDD 570
Cdd:smart00612   1 KIYVVGGFD--GGQRLKS--VEVYDPETNKWTPL-PSMPTPRSGHGVAVING 47
BTB_POZ_ZBTB23_GZF1 cd18211
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-175 3.52e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349520 [Multi-domain]  Cd Length: 128  Bit Score: 46.77  E-value: 3.52e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  18 NLLHGLNLLWRKQLFCDVTLTAQGQ----QFHCHKAVLASCSQYFRSLFSShpplgggvggqdglgapkdqqqppqqqps 93
Cdd:cd18211  11 NLLNEMHKLRLLGHLCDVTVQVEHQgskeEFSAHKAVLAASSKYFKEVFLN----------------------------- 61

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  94 qqqqpppqeepgtpssspdDKLLTSPRAinNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLC 173
Cdd:cd18211  62 -------------------EKISDGKNT--NVMLNEIYTADFASFLEFVYTAKVEVEEDRVQRMLEIAEKLKCLDLSETC 120


                ..
gi 55741643 174 VQ 175
Cdd:cd18211 121 FQ 122
BTB2_POZ_LZTR1 cd18309
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 32-67 4.03e-06

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349618 [Multi-domain]  Cd Length: 126  Bit Score: 46.23  E-value: 4.03e-06
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 55741643  32 FCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPP 67
Cdd:cd18309  20 FCDITLLLDGHPIPAHKAILAARCSYFEAMFRSFMP 55
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 32-173 4.14e-06

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 45.41  E-value: 4.14e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  32 FCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSshpplgggvggqdglgapkdqqqppqqqpsqqqqpppqeePGTPSSSp 111
Cdd:cd18314   6 FSDVVLCVGDRKFFAHRIVLCARSPVFRSMLT----------------------------------------GSMIESN- 44

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 55741643 112 ddklltspraINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLC 173
Cdd:cd18314  45 ----------LKEVTLEDVEPEIFETVLKYMYTGQVTLSEENVLDLLMLASKYQVPDLEKLC 96
BTB_POZ_ZBTB30_HIC2 cd18334
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-61 4.68e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349643 [Multi-domain]  Cd Length: 120  Bit Score: 46.11  E-value: 4.68e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 55741643  13 PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSL 61
Cdd:cd18334   2 PNHAKQLLLQLNQQRAKGFLCDVIIVVENALFRAHKNILAASSMYFKSL 50
BTB_POZ_ZBTB34 cd18220
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-59 4.86e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349529 [Multi-domain]  Cd Length: 120  Bit Score: 46.17  E-value: 4.86e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 55741643  11 FD-PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFR 59
Cdd:cd18220   3 FDvPEYSNTVLSQLNELRLQGKLCDIIVHIQGQPFRAHKAVLAASSPYFR 52
BTB_POZ_ZBTB29_HIC1 cd18333
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-61 5.24e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349642 [Multi-domain]  Cd Length: 121  Bit Score: 46.05  E-value: 5.24e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 55741643  13 PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSL 61
Cdd:cd18333   2 PSHSRQLLLQLNTQRTKGFLCDVIIVVQNALFRAHKNILAASSVYLKSL 50
BTB_POZ_ZBTB46 cd18230
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-183 5.74e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349539 [Multi-domain]  Cd Length: 125  Bit Score: 45.82  E-value: 5.74e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  13 PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSShpplgggvggqdglgapkdqqqppqqqp 92
Cdd:cd18230   2 TSHYRHLLRELNEQRQHGILCDVCIIVEGKIFKAHKNVLLGSSRYFKTLYCQ---------------------------- 53

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  93 sqqqqPPPQEEPGTPSSspddklltsprainnlvLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKL 172
Cdd:cd18230  54 -----VQKTSDQATVTH-----------------LDIVTAQGFKAIIDFMYSAHLALTSKNVIEVMSAASYLQMTDIVQA 111

                       170
                ....*....|.
gi 55741643 173 CVQFLNDQISV 183
Cdd:cd18230 112 CHNFIKAALDI 122
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-64 6.10e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 45.35  E-value: 6.10e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 55741643  16 SDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSS 64
Cdd:cd18292   1 SREFLQDIAQLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSN 49
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 26-62 7.05e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 45.60  E-value: 7.05e-06
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 55741643  26 LWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLF 62
Cdd:cd18279  12 LWENSRFTDCCLCVGGQEFQAHKAILAARSPVFSAMF 48
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 21-178 7.98e-06

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 44.89  E-value: 7.98e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  21 HGLNLLWRKQLFCDVTLTAQGQQ-FHCHKAVLASCSQYFRSLFSSHPPLGggvggqdglgapkdqqqppqqqpsqqqqpp 99
Cdd:cd18299   1 EDLRNLLHSPSCADVVFILQGGVrIFAHRIVLAAASSVFADLFLMMTVVT------------------------------ 50

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 55741643 100 pqeepgtpssspddklltspraINNLVLQGCssigLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLN 178
Cdd:cd18299  51 ----------------------LDSDITPEA----FRRVLEFLYTGVLDENEDDLKELKDAAELLELFDLVMMCTNVLN 103
BTB_POZ_TDPOZ cd18344
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-62 8.27e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349653 [Multi-domain]  Cd Length: 128  Bit Score: 45.72  E-value: 8.27e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 55741643  12 DPSHSdnLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLF 62
Cdd:cd18344   5 DPRHM--LTDDLGELWENSLFTDCCLLVAGHEFRAHKAILAARSPVFRAMF 53
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 24-185 9.15e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 45.42  E-value: 9.15e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  24 NLLWRKQLfCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHpplgggvggqdglgapkdqqqppqqqpsqqQQPPPQEE 103
Cdd:cd18336  12 NYLQHKQL-CDVLLIAGNLKIPAHRLVLSAVSDYFAAMFTND------------------------------VREAKQEE 60

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643 104 pgtpssspddklltsprainnLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISV 183
Cdd:cd18336  61 ---------------------IKMEGVDPDALKALVHYAYTGVLELKEDTIESLLAAACLLQLSQVIDVCCNFLMKQLHP 119


                ..
gi 55741643 184 QN 185
Cdd:cd18336 120 SN 121
BTB_POZ_ZBTB43 cd18227
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-58 9.41e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349536 [Multi-domain]  Cd Length: 121  Bit Score: 45.32  E-value: 9.41e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 55741643  13 PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYF 58
Cdd:cd18227   6 PDFSSTILQKLNQQRQQGQLCDISVVVQGHLFRAHKAVLAASSPYF 51
Kelch smart00612
Kelch domain;
374-424 9.66e-06

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 42.93  E-value: 9.66e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 55741643    374 LFVLGGedqWNpnGKHSTNFVSRYDPRFNSWIQLPPMQERRASFYACRLDK 424
Cdd:smart00612   2 IYVVGG---FD--GGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch_3 pfam13415
Galactose oxidase, central domain;
423-469 1.06e-05

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 43.05  E-value: 1.06e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 55741643   423 DKHLYVIGGRNETG--YLSSVECYNLETNEWRYVSSLPQPLAAHAGAVH 469
Cdd:pfam13415   1 GDKLYIFGGLGFDGqtRLNDLYVYDLDTNTWTQIGDLPPPRSGHSATYI 49
BTB_POZ_KLHL17_actinfilin cd18246
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1-64 1.18e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349555 [Multi-domain]  Cd Length: 139  Bit Score: 45.41  E-value: 1.18e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 55741643   1 MSRSGDRTSTFDPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSS 64
Cdd:cd18246   8 LNRDGHSISHNSKRHYHDAFVSMNRMRQRGLLCDIVLHVGTKEIKAHKVVLASCSPYFHAMFTN 71
BTB_POZ_ZBTB27_BCL6 cd18331
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-63 1.36e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349640 [Multi-domain]  Cd Length: 118  Bit Score: 44.85  E-value: 1.36e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 55741643  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFS 63
Cdd:cd18331   7 HASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFT 55
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 560-602 1.86e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 42.21  E-value: 1.86e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 55741643   560 RSGPGCAVLDDSIYLVGGysWSMGAYKSSTICYCPEKGTWTEL 602
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGG--FDGNQSLNSVEVYDPETNTWSKL 42
BTB_POZ_KBTBD11 cd18275
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-189 2.09e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349584 [Multi-domain]  Cd Length: 104  Bit Score: 43.63  E-value: 2.09e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  34 DVTLTAQGQQFHCHKAVLASCSQYFRSLFSshpplgggvggqdglgapkdqqqppqqqpsqqqqpppqeepgtpssspdd 113
Cdd:cd18275   6 DLVIEVSGQRIRAHKSVLAAKSDYFRARLS-------------------------------------------------- 35

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 55741643 114 klltspRAInnLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQNYKQV 189
Cdd:cd18275  36 ------RDI--LKVKGLSYATLRLLVDYVYSGRMAVSKDNVVEVVAGARFLQMPCAAQCAVDAVRAQLCLGNCYEV 103
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 363-411 2.50e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 41.83  E-value: 2.50e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 55741643   363 AHHCVVEVENFLFVLGGEDqwnpnGKHSTNFVSRYDPRFNSWIQLPPMQ 411
Cdd:pfam01344   3 SGAGVVVVGGKIYVIGGFD-----GNQSLNSVEVYDPETNTWSKLPSMP 46
BACK_KLHL8 cd18448
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ...
 189-267 2.67e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.


Pssm-ID: 350523 [Multi-domain]  Cd Length: 97  Bit Score: 43.06  E-value: 2.67e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643 189 VCKIAALHGLEETKKLANKY---------LVEDVLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPD 259
Cdd:cd18448  10 VRTFAEQHNRVDLMKMADKYacdhfnevvECEEFVSISAQHLEKLISSSDLNVESESQVYEAVMKWVKHDPQHRKRHLDD 89


                ....*...
gi 55741643 260 LMKRLRFA 267
Cdd:cd18448  90 LLSQVRLP 97
BTB_POZ_ZBTB9 cd18200
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-58 2.90e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349509 [Multi-domain]  Cd Length: 111  Bit Score: 43.69  E-value: 2.90e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 55741643  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYF 58
Cdd:cd18200   1 YSSALLETLNKHRLEGKFCDLSVHVQGRVFRAHKAVLAASSPYF 44
BTB_POZ_ZBTB40 cd18225
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-64 3.01e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349534 [Multi-domain]  Cd Length: 116  Bit Score: 43.66  E-value: 3.01e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 55741643  13 PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSS 64
Cdd:cd18225   4 PNYSRQLLQQLHTLRKEQQFCDCTIFIGTFHFRAHKLVLAASSLLFKSLLDS 55
Kelch_6 pfam13964
Kelch motif;
414-460 3.56e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 41.55  E-value: 3.56e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 55741643   414 RASFYACRLDKHLYVIGGR-NETGYLSSVECYNLETNEWRYVSSLPQP 460
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYtNASPALNKLEVYNPLTKSWEELPPLPTP 49
BACK_KLHL40_KBTBD5 cd18516
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also ...
 211-270 3.78e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5, or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy.


Pssm-ID: 350591 [Multi-domain]  Cd Length: 99  Bit Score: 42.82  E-value: 3.78e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643 211 EDVLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMKRLRFALIP 270
Cdd:cd18516  40 EDFLQLSPDELIAIISSDSLNVEKEEDVFEAVMKWVGKDQEERTKALPVLLESIRFRLMP 99
BTB_POZ_KLHL11 cd18241
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-185 4.10e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349550 [Multi-domain]  Cd Length: 135  Bit Score: 43.69  E-value: 4.10e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  21 HGLNLLWRKQ------LFCDVTLT---AQGQQFHCHKAVLASCSQYFRSLFSSHpplgggvggqdglgapkdqqqPPQQQ 91
Cdd:cd18241   6 HCSELSWRQNeqrkqgLFCDITLAfggAGGREFRAHRSVLAAATEYFTPLLSGQ---------------------FSESR 64

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  92 PSQQQQPPPQEEPGtpsssPDDKLLTSprainnlvlqgcssiglrlVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTK 171
Cdd:cd18241  65 SGRVEMRKWSSEPG-----PDPDTVEA-------------------VIQYMYTGRIRVSTGNVHEVLELADRFLLIRLKE 120

                       170
                ....*....|....
gi 55741643 172 LCVQFLNDQISVQN 185
Cdd:cd18241 121 FCGEFLKKKLNLSN 134
BTB_POZ_ZBTB8 cd18199
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-63 4.36e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349508 [Multi-domain]  Cd Length: 113  Bit Score: 43.18  E-value: 4.36e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 55741643  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFS 63
Cdd:cd18199   1 HQSRLLGQLNEQRKQDFFCDCSIIVEGRIFKAHRNVLFASSGYFRMLLS 49
BTB_POZ_ZBTB47_ZNF651 cd18231
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-180 5.23e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349540 [Multi-domain]  Cd Length: 115  Bit Score: 42.99  E-value: 5.23e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  34 DVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPPLGGGvggqdglgapkdqqqppqqqpsqqqqpppqeepgtpssspdd 113
Cdd:cd18231  18 DIVLVRQRSTFPAHKGVLAAYSQFFHSLFTQNKQLQRV------------------------------------------ 55

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 55741643 114 klltsprainNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQ 180
Cdd:cd18231  56 ----------ELSLEALTSQGLQQILNFIYTSKLLVNSCNVQDVLNAAAVLQMNDIAASCQELIDSR 112
BACK_KLHL1 cd18509
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a ...
 193-276 5.82e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton in brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350584 [Multi-domain]  Cd Length: 106  Bit Score: 42.70  E-value: 5.82e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643 193 AALHGLEETKKLANKYLVEDV---------LLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMKR 263
Cdd:cd18509  14 ADAQGCIELMKVAHSYTMENImevirnqefLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQRRCSDLSMLLAY 93

                        90
                ....*....|...
gi 55741643 264 LRFALIPAPELVE 276
Cdd:cd18509  94 IRLPLLPPQLLAD 106
BTB_POZ_ZBTB14 cd18204
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-65 6.02e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349513 [Multi-domain]  Cd Length: 114  Bit Score: 42.72  E-value: 6.02e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 55741643  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSH 65
Cdd:cd18204   1 HKTVFLKTLNEQRLEGEFCDIAIVVEDVKFRAHRCVLAACSTYFKKLFKKL 51
BTB_POZ_ZBTB22_BING1 cd18210
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-58 6.12e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349519 [Multi-domain]  Cd Length: 112  Bit Score: 42.52  E-value: 6.12e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 55741643  13 PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYF 58
Cdd:cd18210   2 PEITSSLLESLNQQRMEGKLCDISIHVQGRVFRAHRAVLAASSPYF 47
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 511-555 8.05e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 40.29  E-value: 8.05e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 55741643   511 HTLAVMNDRLYAIGGnhLKGFSHLDVmlVECYDPKGDQWNILQTP 555
Cdd:pfam01344   5 AGVVVVGGKIYVIGG--FDGNQSLNS--VEVYDPETNTWSKLPSM 45
Kelch_6 pfam13964
Kelch motif;
363-414 9.43e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 40.40  E-value: 9.43e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 55741643   363 AHHCVVEVENFLFVLGGEDQWNPngkhSTNFVSRYDPRFNSWIQLPPMQERR 414
Cdd:pfam13964   3 TFHSVVSVGGYIYVFGGYTNASP----ALNKLEVYNPLTKSWEELPPLPTPR 50
BACK_KLHL32_BKLHD5 cd18471
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also ...
 185-269 9.74e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also termed BTB and kelch domain-containing protein 5 (BKLHD5), belongs to the KLHL family. Its function remains unclear. KLHL32 SNPs may be associated with body mass index in individuals of African ancestry.


Pssm-ID: 350546 [Multi-domain]  Cd Length: 98  Bit Score: 41.81  E-value: 9.74e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643 185 NYKQVCKIAALHGLEETKKLANKYLV-----------EDVLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDreTR 253
Cdd:cd18471   5 NYLDLYKLADLFNLTLLEEAVVDFLVkhlsellkshpEEVLALPYRLLREVLKSDRLTSLSEEQIWQLAVRWLEHN--CR 82

                        90
                ....*....|....*.
gi 55741643 254 MQYAPDLMKRLRFALI 269
Cdd:cd18471  83 YQYMDELLQYVRFGLM 98
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 33-62 1.01e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 42.32  E-value: 1.01e-04
                        10        20        30
                ....*....|....*....|....*....|
gi 55741643  33 CDVTLTAQGQQFHCHKAVLASCSQYFRSLF 62
Cdd:cd18280  15 ADVTFNVDGEKFRAHKLVLAARSPVFRSML 44
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 34-65 1.07e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 42.25  E-value: 1.07e-04
                        10        20        30
                ....*....|....*....|....*....|..
gi 55741643  34 DVTLTAQGQQFHCHKAVLASCSQYFRSLFSSH 65
Cdd:cd18286  19 DITIKVDGKTFKAHRCILCARSSYFAAMLSGS 50
BTB_POZ_ZBTB5 cd18196
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-63 1.11e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349505 [Multi-domain]  Cd Length: 126  Bit Score: 42.34  E-value: 1.11e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 55741643  13 PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFS 63
Cdd:cd18196   2 PGHFEQIFQQLNYQRLHGQLCDCVIVVGNRHFKAHRSVLAACSTHFRALFT 52
BTB_POZ_ZBTB31_myoneurin cd18217
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-173 1.27e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349526 [Multi-domain]  Cd Length: 111  Bit Score: 41.66  E-value: 1.27e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFsshpplgggvggqdglgapkdqqqppqqqpsq 94
Cdd:cd18217   1 HCEQLLERLNKQREAGFLCDCTIVIGQFQFKAHRNVLAAFSEYFGAQY-------------------------------- 48

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 55741643  95 qqqpppqeepgtpSSSPDDKLLTSPRAInnlvlqgcSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLC 173
Cdd:cd18217  49 -------------KDTEDNIVFLDQSQV--------SADGFQKLLEFIYTGNLNLDSWNVAEIHQAASYLGMEEVVAKC 106
BACK_KBTBD12 cd18485
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 197-269 1.44e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also termed Kelch domain-containing protein 6 (KLHDC6), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350560 [Multi-domain]  Cd Length: 100  Bit Score: 41.25  E-value: 1.44e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643 197 GLEETKKLANKYLV---------EDVLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMKRLRFA 267
Cdd:cd18485  17 GAEDLSDRARKYLYqhftevclhEEVLEIEAHQLLTLIKSDDLNVSREESILDLVLRWVNHNRKSRVQHLVELLKQVRLE 96


                ..
gi 55741643 268 LI 269
Cdd:cd18485  97 LV 98
BACK_KBTBD2 cd18479
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 173-265 3.12e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulating the insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation.


Pssm-ID: 350554 [Multi-domain]  Cd Length: 96  Bit Score: 40.42  E-value: 3.12e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643 173 CVQFLN--DQISVQNYKQVCKIAALHgleetkKLANKYLVEDVLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDR 250
Cdd:cd18479   6 CVRLLSfaDLFSCEELKQSAKRMVEH------KFTAVYHQEAFMQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYNT 79

                        90
                ....*....|....*
gi 55741643 251 ETRMQYAPDLMKRLR 265
Cdd:cd18479  80 ESRSQYLSSVLSQIR 94
BTB1_POZ_BTBD7 cd18283
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 32-66 3.59e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349592 [Multi-domain]  Cd Length: 92  Bit Score: 40.01  E-value: 3.59e-04
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 55741643  32 FC-DVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHP 66
Cdd:cd18283   1 YCtDVDLVFQGTCFPVHRAILSARCPFFRDLLSSSP 36
muta_rot_YjhT TIGR03547
mutatrotase, YjhT family; Members of this protein family contain multiple copies of the ...
 457-578 3.86e-04

mutatrotase, YjhT family; Members of this protein family contain multiple copies of the beta-propeller-forming Kelch repeat. All are full-length homologs to YjhT of Escherichia coli, which has been identified as a mutarotase for sialic acid. This protein improves bacterial ability to obtain host sialic acid, and thus serves as a virulence factor. Some bacteria carry what appears to be a cyclically permuted homolog of this protein.


Pssm-ID: 274641 [Multi-domain]  Cd Length: 346  Bit Score: 43.08  E-value: 3.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643   457 LPQPLAAHAGAVHNGKIYI---SGGVHngeyvpWLYCYDPVMDV-WARKQDMNT-KRAIHTLAVMNDRLYAIGG---NHL 528
Cdd:TIGR03547   4 LPVGFKNGTGAIIGDKVYVglgSAGTS------WYKLDLKKPSKgWQKIADFPGgPRNQAVAAAIDGKLYVFGGigkANS 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 55741643   529 KGFSHLdVMLVECYDPKGDQWNILQTPILEGRSGPGCAVLDDS-IYLVGGY 578
Cdd:TIGR03547  78 EGSPQV-FDDVYRYDPKKNSWQKLDTRSPVGLLGASGFSLHNGqAYFTGGV 127
Kelch_6 pfam13964
Kelch motif;
462-508 4.93e-04

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 38.09  E-value: 4.93e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 55741643   462 AAHAGAVHNGKIYISGG-VHNGEYVPWLYCYDPVMDVWARKQDMNTKR 508
Cdd:pfam13964   3 TFHSVVSVGGYIYVFGGyTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 34-65 5.64e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 39.58  E-value: 5.64e-04
                        10        20        30
                ....*....|....*....|....*....|..
gi 55741643  34 DVTLTAQGQQFHCHKAVLASCSQYFRSLFSSH 65
Cdd:cd18301  20 DVVFQVGGKTFPAHKFILASRSDYFRKLFLSS 51
BTB_POZ_ZBTB26_Bioref cd18214
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-62 7.35e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 26 (ZBTB26); ZBTB26, also called zinc finger protein 481 (ZNF481) or zinc finger protein Bioref, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349523 [Multi-domain]  Cd Length: 122  Bit Score: 39.81  E-value: 7.35e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 55741643  14 SHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLF 62
Cdd:cd18214   7 NYGDSMLQKMNKLREQNKFCDVTVHIDDLEVPGHKVVFAAGSPFLRDQF 55
BTB_POZ_ZBTB8B cd18330
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-177 8.54e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349639 [Multi-domain]  Cd Length: 113  Bit Score: 39.53  E-value: 8.54e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  19 LLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHpplgggvggqdglgapkdqqqppqqqpsqqqqp 98
Cdd:cd18330   5 LLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLIHY--------------------------------- 51

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 55741643  99 ppQEEPGTPSSSPDDKLltsprainnlvlqgcSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFL 177
Cdd:cd18330  52 --IQDSGRHSTASLDIV---------------TSEAFSIILDFLYSGKLDLCSENVIEVMSAASYLQMTDVVNFCKGYI 113
BACK_KLHL25_like cd18464
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The ...
 205-270 8.90e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The family includes KLHL25 and KLHL37. KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350539 [Multi-domain]  Cd Length: 98  Bit Score: 39.02  E-value: 8.90e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 55741643 205 ANKYLVEDVLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMKRLRFALIP 270
Cdd:cd18464  33 TTLRKTEDFLSLPKDKLLELVSSEELEVEDERLVYEAVIGWIRYDLPRRHEVLPELLRSVRLALLP 98
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 559-605 8.95e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 37.32  E-value: 8.95e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 55741643   559 GRSGPGCAVLDDSIYLVGGYSWSMGAYKSSTICYCPEKGTWTELEGD 605
Cdd:pfam07646   1 PRYPHASSVPGGKLYVVGGSDGLGDLSSSDVLVYDPETNVWTEVPRL 47
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-185 9.31e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 39.18  E-value: 9.31e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  34 DVTLTAQGQQFHCHKAVLASCSQYFRSLFSShpplgggvggqdglgapkdqqqppqqqpsqqqqpppqeePGTPSSSPDD 113
Cdd:cd18297  14 DVTFLVEGRPFYAHKIVLVTASDRFKSMLSS---------------------------------------GSTEAQTPVI 54

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 55741643 114 KlltspraINNL---VLQgcssiglrLVLEYLYTANV---TLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQN 185
Cdd:cd18297  55 E-------IPDIrydIFQ--------LMMQYLYTGGVeslDVAQDDALELLRAASFFQLDGLKRHCEILLSQQIDLDN 117
BTB_POZ_calicin cd18307
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 32-176 9.61e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349616 [Multi-domain]  Cd Length: 97  Bit Score: 39.02  E-value: 9.61e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  32 FCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHpplgggvggqdglgapkdqqqppqqqpsqqqqpppqeepgtpSSSP 111
Cdd:cd18307   1 FCDVVISVDNHSFAAHRNVLAAVSPFVKSLISSN------------------------------------------DMKA 38

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 55741643 112 DDKLLTSprainnLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQF 176
Cdd:cd18307  39 TDELSIT------IDCDYLSPETVEQLLDYFYTGKIVISEKNVEDLLKGAKYFNIPRLKDHCVDF 97
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-66 1.43e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 39.22  E-value: 1.43e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 55741643  23 LNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFsSHP 66
Cdd:cd18343  12 LGNLWENSRFTDCSLFVGGQEFKAHKSILAARSPVFNAMF-EHE 54
BTB_POZ_ZBTB16_PLZF cd18205
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-62 1.48e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 16 (ZBTB16); ZBTB16 is also called promyelocytic leukemia zinc finger protein, zinc finger protein 145, or zinc finger protein PLZF. It is a DNA-binding transcription factor essential for undifferentiated cell maintenance. ZBTB16 also acts as a downstream transcriptional regulator of Osterix and can be useful as a late marker of osteoblastic differentiation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349514 [Multi-domain]  Cd Length: 107  Bit Score: 38.48  E-value: 1.48e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 55741643  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLF 62
Cdd:cd18205   1 HPTGLLHKANQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFEILF 48
Kelch_4 pfam13418
Galactose oxidase, central domain;
565-602 1.58e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 36.82  E-value: 1.58e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 55741643   565 CAVLDDSIYLVGGYSWSMGAYkSSTICYCPEKGTWTEL 602
Cdd:pfam13418   8 TSIPDDTIYLFGGEGEDGTLL-SDLWVFDLSTNEWTRL 44
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 35-64 1.63e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 37.65  E-value: 1.63e-03
                        10        20        30
                ....*....|....*....|....*....|
gi 55741643  35 VTLTAQGQQFHCHKAVLASCSQYFRSLFSS 64
Cdd:cd01165   1 VVLVVEGEKFHVNKELLAQSSEYFRALFRG 30
BACK_KLHL40_like cd18477
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The ...
 211-270 1.74e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells.


Pssm-ID: 350552 [Multi-domain]  Cd Length: 99  Bit Score: 38.28  E-value: 1.74e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643 211 EDVLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMKRLRFALIP 270
Cdd:cd18477  40 EDFLGLSADELIAIISSDGLNVEKEEAVFEAVMKWVREAKENRQKALPTVFESIRFRLLP 99
BACK_KLHL4 cd18510
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares ...
 196-275 2.01e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350585 [Multi-domain]  Cd Length: 106  Bit Score: 38.36  E-value: 2.01e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643 196 HGLEETKKLANKYLVE---------DVLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMKRLRF 266
Cdd:cd18510  17 QGCTELLKVAHSYTMEhfleviknqEFLLLPASEIVKLLASDDINVPDEETIFQALMMWVRHDLQNRQKDLGMLLSYIRL 96


                ....*....
gi 55741643 267 ALIPaPELV 275
Cdd:cd18510  97 PLLP-PQLL 104
BTB_POZ_BTBD3_6 cd18282
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 136-177 2.22e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349591 [Multi-domain]  Cd Length: 108  Bit Score: 38.15  E-value: 2.22e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 55741643 136 RLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFL 177
Cdd:cd18282  63 LNLLRYLYCDEIDLEPDTVLATLYAAKKYLVPHLARACVQFL 104
BACK_KLHL25_ENC2 cd18514
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also ...
 211-270 2.56e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1).


Pssm-ID: 350589 [Multi-domain]  Cd Length: 99  Bit Score: 37.52  E-value: 2.56e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643 211 EDVLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMKRLRFALIP 270
Cdd:cd18514  40 EDFYSLSKDKLLDLISSDELEIEDEQVVFNAVLQWVKYDLEKRKDYLPELLRNVRLALLP 99
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 413-457 2.62e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 36.16  E-value: 2.62e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 55741643   413 RRASFYACRLDKHLYVIGGRNETG--YLSSVECYNLETNEWRYVSSL 457
Cdd:pfam07646   1 PRYPHASSVPGGKLYVVGGSDGLGdlSSSDVLVYDPETNVWTEVPRL 47
BTB_POZ_ZBTB25_ZNF46_KUP cd18213
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-62 2.62e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25); ZBTB25, also called zinc finger protein 46 (ZNF46) or zinc finger protein KUP, is a transcription repressor that facilitates viral RNA transcription and replication. It interacts with viral RNA-dependent RNA polymerase (RdRp) proteins and modulates their transcription activity. It also functions as a viral RNA-binding protein, binding preferentially to the U-rich sequence within 5' UTR of vRNA. ZBTB25 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349522 [Multi-domain]  Cd Length: 128  Bit Score: 38.34  E-value: 2.62e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 55741643  14 SHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLF 62
Cdd:cd18213   3 SHSLVLLQQLNMQREFGFLCDCTVAIGDVYFKAHRAVLAAFSNYFKMIF 51
BTB_POZ_CP190-like cd18311
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 19-66 2.66e-03

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster centrosomal protein 190kD (CP190) and similar proteins; CP190 is a large, multi-domain protein, first identified as a centrosome protein with oscillatory localization over the course of the cell cycle. It has an essential function in the nucleus as a chromatin insulator. It is known to associate with the nuclear matrix, components of the RNAi machinery, active promoters and borders of the repressive chromatin domains. CP190 contains an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349620 [Multi-domain]  Cd Length: 110  Bit Score: 37.95  E-value: 2.66e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 55741643  19 LLHGLNLLWRKQLFCDVTLTAQ-GQQFHCHKAVLASCSQYFRSLFSSHP 66
Cdd:cd18311   1 FLQRLQNLFNKTEYCDLTLQFRdNEQLKVHRLVLSACTDYFNVLEQTCE 49
BTB_POZ_ZBTB32_FAZF_TZFP cd18218
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-67 2.73e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349527 [Multi-domain]  Cd Length: 110  Bit Score: 38.00  E-value: 2.73e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 55741643  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPP 67
Cdd:cd18218   1 HSDRLLHLAARLRPAGALCDTLITVGSQEFPAHSLVLAGASQQLGRQLTNPNP 53
BTB_POZ_ZBTB42 cd18956
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-66 3.26e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349737 [Multi-domain]  Cd Length: 129  Bit Score: 38.26  E-value: 3.26e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 55741643  13 PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHP 66
Cdd:cd18956   4 PEHGGRLLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFHLFYRDRP 57
Kelch_3 pfam13415
Galactose oxidase, central domain;
569-616 3.29e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 35.73  E-value: 3.29e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 55741643   569 DDSIYLVGGYSWSMGAYKSSTICYCPEKGTWTELeGDVAEPLAGPACV 616
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTRLNDLYVYDLDTNTWTQI-GDLPPPRSGHSAT 47
BTB_POZ_BTBD11 cd18351
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 7-67 3.82e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing protein. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349660 [Multi-domain]  Cd Length: 131  Bit Score: 38.04  E-value: 3.82e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 55741643   7 RTSTFDPshsdnllHGLNllwRKQLfCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPP 67
Cdd:cd18351  10 QTSRLDP-------HFLN---NKEM-SDVTFLVEGRPFYAHKVLLFTASPRFKALLSNKPS 59
BTB_POZ_SPOP cd18342
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 26-62 4.56e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349651 [Multi-domain]  Cd Length: 125  Bit Score: 37.77  E-value: 4.56e-03
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 55741643  26 LWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLF 62
Cdd:cd18342  16 LWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMF 52
BTB_POZ_KLHL1 cd18335
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-177 4.60e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349644 [Multi-domain]  Cd Length: 126  Bit Score: 37.72  E-value: 4.60e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHpplgggvggqdglgapkdqqqppqqqpsq 94
Cdd:cd18335   2 HAEQTFRKMESYLKQQQLCDVILIAGNRKIPAHRLVLSAVSDYFAAMFTSD----------------------------- 52

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  95 qQQPPPQEEpgtpssspddklltsprainnLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCV 174
Cdd:cd18335  53 -VCEAKQEE---------------------IKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLSQVVEVCC 110


                ...
gi 55741643 175 QFL 177
Cdd:cd18335 111 HFL 113
BTB_POZ_KLHL5 cd18337
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 24-185 7.08e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It is abundantly expressed in the ovary, adrenal gland, and thymus. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349646 [Multi-domain]  Cd Length: 130  Bit Score: 37.35  E-value: 7.08e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643  24 NLLWRKQLfCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHpplgggvggqdglgapkdqqqppqqqpsqqQQPPPQEE 103
Cdd:cd18337  16 NYLRHKQL-CDVVLVAGDRRIPAHRLVLSSVSDYFAAMFTND------------------------------VREAKQEE 64

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643 104 pgtpssspddklltsprainnLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISV 183
Cdd:cd18337  65 ---------------------IKMEGVEPNALWALVQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHP 123


                ..
gi 55741643 184 QN 185
Cdd:cd18337 124 SN 125
BACK_KLHL37_ENC1 cd18515
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also ...
 211-270 7.37e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350590 [Multi-domain]  Cd Length: 98  Bit Score: 36.49  E-value: 7.37e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 55741643 211 EDVLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMKRLRFALIP 270
Cdd:cd18515  39 EDFLQLPKDMVVQLLSSEELETEDERLVYEAAINWVNYDLKKRHCYLSELLQTVRLALLP 98
Kelch_3 pfam13415
Galactose oxidase, central domain;
470-515 8.40e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 34.57  E-value: 8.40e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 55741643   470 NGKIYISGG--VHNGEYVPWLYCYDPVMDVWARKQDMNTKRAIHTLAV 515
Cdd:pfam13415   1 GDKLYIFGGlgFDGQTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSATY 48
BTB_POZ_NPR_plant cd18310
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 16-64 9.48e-03

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349619 [Multi-domain]  Cd Length: 145  Bit Score: 36.90  E-value: 9.48e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 55741643  16 SDNLLhglNLLWRKQLFC-DVTLT-AQGQQFHCHKAVLASCSQYFRSLFSS 64
Cdd:cd18310   4 SSDLE---NLLDSPDLFYsDAEIIvEGGRPVPVHRCILAARSPFFRDIFAS 51
Kelch_6 pfam13964
Kelch motif;
560-602 9.67e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 34.62  E-value: 9.67e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 55741643   560 RSGPGCAVLDDSIYLVGGYSwSMGAYKSSTICYCPEKGTWTEL 602
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYT-NASPALNKLEVYNPLTKSWEEL 43
BACK_KLHL16_gigaxonin cd18455
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, ...
 211-267 9.85e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy.


Pssm-ID: 350530 [Multi-domain]  Cd Length: 97  Bit Score: 35.76  E-value: 9.85e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 55741643 211 EDVLLLNFEEMRALL--DSLPppVESELALFQMSVLWLEHDRETRMQYAPDLMKRLRFA 267
Cdd:cd18455  39 EEFLELSPEKLKELLsrDKLN--VGNEEYIFEAVLRWVRHDPEERKVHLKDLMSSCWRS 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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