NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1677530342|ref|NP_065919|]
View 

inactive dipeptidyl peptidase 10 isoform long [Homo sapiens]

Protein Classification

S9 family peptidase( domain architecture ID 12012129)

peptidase S9 family protein, an oligopeptidase which may cleave the prolyl bond of short peptides, similar to oligopeptidase B, which cleaves on the C-terminal side of lysyl and argininyl residues

CATH:  3.40.50.1820|2.140.10.30
EC:  3.4.-.-
Gene Ontology:  GO:0008236|GO:0006508
MEROPS:  S9
PubMed:  19508187|12369917|35631755

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
DPPIV_N pfam00930
Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region ...
 133-499 9.37e-140

Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region to the N-terminal side of the active site. The Prosite motif does not correspond to this Pfam entry.


:

Pssm-ID: 395744 [Multi-domain]  Cd Length: 352  Bit Score: 416.33  E-value: 9.37e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530342 133 SPDLKYVLLAYDVKQIFHYSYTASYVIYNIHTREVWELNPPEvedSVLQYAAWGVQGQQLIYIFENNIYYQPDIKSSSLR 212
Cdd:pfam00930   1 SPDGKYLLLATNYTKNWRHSYTADYYIYDLETNRVEPLPPGE---GKIQDAKWSPDGDRLAFVRDNNLYVRELATGKEIQ 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530342 213 LTSSGkEEIIFNGIADWLYEEELLHSHIAHWWSPDGERLAFLMINDSLVPTMVIPRFT-GALYPKGKQYPYPKAGQVNPT 291
Cdd:pfam00930  78 ITSDG-SDGIFNGVADWVYEEEVLGSNSAVWWSPDGSRLAFLRFDESEVPIITLPYYTdEGPGPEVREIKYPKAGAPNPT 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530342 292 IKLYVVNLYGPTHTlELMPPDSFKSREYYITMVKWVSNTKTVVRWLNRAQNISILTVCETTTGACSKKYEMTSDTWLSQQ 371
Cdd:pfam00930 157 VELFVYDLASGKTV-EVVPPDDLSDADYYITRVKWVPDGKLLVQWLNRDQNRLKVVLCDAETGRTVVILEETSDGWVELH 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530342 372 NEEPVFSRDGSKFFMTVPvKQGgrgeFHHVAMFLIQSKSeqitVRHLTSGNWEVIKILAYDETTQKIYFLSTESSPRGRQ 451
Cdd:pfam00930 236 QDPHFIKRDGSGFLWISE-RDG----YNHLYLYDLDGKS----PIQLTSGNWEVTSILGVDETRDLVYFTATEDSPTERH 306

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 1677530342 452 LYSASTEGLLNRQCISCNFMKEqctYFDASFSPMNQHFLLFCEGPRVP 499
Cdd:pfam00930 307 LYSVSLDSGGEPTCLTDDSGDH---DYSASFSPNGSYYVLTYSGPDTP 351
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
580-782 2.84e-49

Prolyl oligopeptidase family;


:

Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 172.80  E-value: 2.84e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530342 580 FHIDWD-SVLIDMDnVIVARFDGRGSGFQGLKILQEIHRRLGSVEVKDQITAVKFLLKLPYIDSKRLSIFGKGYGGYIAS 658
Cdd:pfam00326   1 PSFSWNaQLLADRG-YVVAIANGRGSGGYGEAFHDAGKGDLGQNEFDDFIAAAEYLIEQGYTDPDRLAIWGGSYGGYLTG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530342 659 MILKSDEKLFKCGSVVAPITDLKLYAS----AFSERYLGMPS--KEESTYQAASVLHNVHGLKEEN-ILIIHGTADTKVH 731
Cdd:pfam00326  80 AALNQRPDLFKAAVAHVPVVDWLAYMSdtslPFTERYMEWGNpwDNEEGYDYLSPYSPADNVKVYPpLLLIHGLLDDRVP 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1677530342 732 FQHSAELIKHLIKAGVNYTMQVYPDEGHNV-SEKSKYHLYSTILKFFSDCLK 782
Cdd:pfam00326 160 PWQSLKLVAALQRKGVPFLLLIFPDEGHGIgKPRNKVEEYARELAFLLEYLG 211
 
Name Accession Description Interval E-value
DPPIV_N pfam00930
Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region ...
 133-499 9.37e-140

Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region to the N-terminal side of the active site. The Prosite motif does not correspond to this Pfam entry.


Pssm-ID: 395744 [Multi-domain]  Cd Length: 352  Bit Score: 416.33  E-value: 9.37e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530342 133 SPDLKYVLLAYDVKQIFHYSYTASYVIYNIHTREVWELNPPEvedSVLQYAAWGVQGQQLIYIFENNIYYQPDIKSSSLR 212
Cdd:pfam00930   1 SPDGKYLLLATNYTKNWRHSYTADYYIYDLETNRVEPLPPGE---GKIQDAKWSPDGDRLAFVRDNNLYVRELATGKEIQ 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530342 213 LTSSGkEEIIFNGIADWLYEEELLHSHIAHWWSPDGERLAFLMINDSLVPTMVIPRFT-GALYPKGKQYPYPKAGQVNPT 291
Cdd:pfam00930  78 ITSDG-SDGIFNGVADWVYEEEVLGSNSAVWWSPDGSRLAFLRFDESEVPIITLPYYTdEGPGPEVREIKYPKAGAPNPT 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530342 292 IKLYVVNLYGPTHTlELMPPDSFKSREYYITMVKWVSNTKTVVRWLNRAQNISILTVCETTTGACSKKYEMTSDTWLSQQ 371
Cdd:pfam00930 157 VELFVYDLASGKTV-EVVPPDDLSDADYYITRVKWVPDGKLLVQWLNRDQNRLKVVLCDAETGRTVVILEETSDGWVELH 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530342 372 NEEPVFSRDGSKFFMTVPvKQGgrgeFHHVAMFLIQSKSeqitVRHLTSGNWEVIKILAYDETTQKIYFLSTESSPRGRQ 451
Cdd:pfam00930 236 QDPHFIKRDGSGFLWISE-RDG----YNHLYLYDLDGKS----PIQLTSGNWEVTSILGVDETRDLVYFTATEDSPTERH 306

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 1677530342 452 LYSASTEGLLNRQCISCNFMKEqctYFDASFSPMNQHFLLFCEGPRVP 499
Cdd:pfam00930 307 LYSVSLDSGGEPTCLTDDSGDH---DYSASFSPNGSYYVLTYSGPDTP 351
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
580-782 2.84e-49

Prolyl oligopeptidase family;


Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 172.80  E-value: 2.84e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530342 580 FHIDWD-SVLIDMDnVIVARFDGRGSGFQGLKILQEIHRRLGSVEVKDQITAVKFLLKLPYIDSKRLSIFGKGYGGYIAS 658
Cdd:pfam00326   1 PSFSWNaQLLADRG-YVVAIANGRGSGGYGEAFHDAGKGDLGQNEFDDFIAAAEYLIEQGYTDPDRLAIWGGSYGGYLTG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530342 659 MILKSDEKLFKCGSVVAPITDLKLYAS----AFSERYLGMPS--KEESTYQAASVLHNVHGLKEEN-ILIIHGTADTKVH 731
Cdd:pfam00326  80 AALNQRPDLFKAAVAHVPVVDWLAYMSdtslPFTERYMEWGNpwDNEEGYDYLSPYSPADNVKVYPpLLLIHGLLDDRVP 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1677530342 732 FQHSAELIKHLIKAGVNYTMQVYPDEGHNV-SEKSKYHLYSTILKFFSDCLK 782
Cdd:pfam00326 160 PWQSLKLVAALQRKGVPFLLLIFPDEGHGIgKPRNKVEEYARELAFLLEYLG 211
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
595-782 3.82e-41

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 150.55  E-value: 3.82e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530342 595 IVARFDGRGSGFQGlkilqeihRRLGSVEVKDQITAVKFLLKLPYIDSKRLSIFGKGYGGYIASMILKSDEKLFKCGSVV 674
Cdd:COG1506    53 AVLAPDYRGYGESA--------GDWGGDEVDDVLAAIDYLAARPYVDPDRIGIYGHSYGGYMALLAAARHPDRFKAAVAL 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530342 675 APITDLKLYA---SAFSERYLGMPSKEESTYQAASVLHNVHGLKEeNILIIHGTADTKVHFQHSAELIKHLIKAGVNYTM 751
Cdd:COG1506   125 AGVSDLRSYYgttREYTERLMGGPWEDPEAYAARSPLAYADKLKT-PLLLIHGEADDRVPPEQAERLYEALKKAGKPVEL 203

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1677530342 752 QVYPDEGHNVSEKSKYHLYSTILKFFSDCLK 782
Cdd:COG1506   204 LVYPGEGHGFSGAGAPDYLERILDFLDRHLK 234
PLN02442 PLN02442
S-formylglutathione hydrolase
 631-759 3.07e-04

S-formylglutathione hydrolase


Pssm-ID: 178061 [Multi-domain]  Cd Length: 283  Bit Score: 43.61  E-value: 3.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530342 631 VKFLLKL-----PYIDSKRLSIFGKGYGGYIASMI-LKSDEKlFKCGSVVAPI---TDLKLYASAFSErYLGmPSKEE-S 700
Cdd:PLN02442  126 VKELPKLlsdnfDQLDTSRASIFGHSMGGHGALTIyLKNPDK-YKSVSAFAPIanpINCPWGQKAFTN-YLG-SDKADwE 202

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530342 701 TYQAASVLHNVHGLKEEnILIIHGTADTKVHFQHSAELIKHLIK-AGVNYTMQVYPDEGH 759
Cdd:PLN02442  203 EYDATELVSKFNDVSAT-ILIDQGEADKFLKEQLLPENFEEACKeAGAPVTLRLQPGYDH 261
 
Name Accession Description Interval E-value
DPPIV_N pfam00930
Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region ...
 133-499 9.37e-140

Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region to the N-terminal side of the active site. The Prosite motif does not correspond to this Pfam entry.


Pssm-ID: 395744 [Multi-domain]  Cd Length: 352  Bit Score: 416.33  E-value: 9.37e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530342 133 SPDLKYVLLAYDVKQIFHYSYTASYVIYNIHTREVWELNPPEvedSVLQYAAWGVQGQQLIYIFENNIYYQPDIKSSSLR 212
Cdd:pfam00930   1 SPDGKYLLLATNYTKNWRHSYTADYYIYDLETNRVEPLPPGE---GKIQDAKWSPDGDRLAFVRDNNLYVRELATGKEIQ 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530342 213 LTSSGkEEIIFNGIADWLYEEELLHSHIAHWWSPDGERLAFLMINDSLVPTMVIPRFT-GALYPKGKQYPYPKAGQVNPT 291
Cdd:pfam00930  78 ITSDG-SDGIFNGVADWVYEEEVLGSNSAVWWSPDGSRLAFLRFDESEVPIITLPYYTdEGPGPEVREIKYPKAGAPNPT 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530342 292 IKLYVVNLYGPTHTlELMPPDSFKSREYYITMVKWVSNTKTVVRWLNRAQNISILTVCETTTGACSKKYEMTSDTWLSQQ 371
Cdd:pfam00930 157 VELFVYDLASGKTV-EVVPPDDLSDADYYITRVKWVPDGKLLVQWLNRDQNRLKVVLCDAETGRTVVILEETSDGWVELH 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530342 372 NEEPVFSRDGSKFFMTVPvKQGgrgeFHHVAMFLIQSKSeqitVRHLTSGNWEVIKILAYDETTQKIYFLSTESSPRGRQ 451
Cdd:pfam00930 236 QDPHFIKRDGSGFLWISE-RDG----YNHLYLYDLDGKS----PIQLTSGNWEVTSILGVDETRDLVYFTATEDSPTERH 306

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 1677530342 452 LYSASTEGLLNRQCISCNFMKEqctYFDASFSPMNQHFLLFCEGPRVP 499
Cdd:pfam00930 307 LYSVSLDSGGEPTCLTDDSGDH---DYSASFSPNGSYYVLTYSGPDTP 351
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
580-782 2.84e-49

Prolyl oligopeptidase family;


Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 172.80  E-value: 2.84e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530342 580 FHIDWD-SVLIDMDnVIVARFDGRGSGFQGLKILQEIHRRLGSVEVKDQITAVKFLLKLPYIDSKRLSIFGKGYGGYIAS 658
Cdd:pfam00326   1 PSFSWNaQLLADRG-YVVAIANGRGSGGYGEAFHDAGKGDLGQNEFDDFIAAAEYLIEQGYTDPDRLAIWGGSYGGYLTG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530342 659 MILKSDEKLFKCGSVVAPITDLKLYAS----AFSERYLGMPS--KEESTYQAASVLHNVHGLKEEN-ILIIHGTADTKVH 731
Cdd:pfam00326  80 AALNQRPDLFKAAVAHVPVVDWLAYMSdtslPFTERYMEWGNpwDNEEGYDYLSPYSPADNVKVYPpLLLIHGLLDDRVP 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1677530342 732 FQHSAELIKHLIKAGVNYTMQVYPDEGHNV-SEKSKYHLYSTILKFFSDCLK 782
Cdd:pfam00326 160 PWQSLKLVAALQRKGVPFLLLIFPDEGHGIgKPRNKVEEYARELAFLLEYLG 211
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
595-782 3.82e-41

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 150.55  E-value: 3.82e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530342 595 IVARFDGRGSGFQGlkilqeihRRLGSVEVKDQITAVKFLLKLPYIDSKRLSIFGKGYGGYIASMILKSDEKLFKCGSVV 674
Cdd:COG1506    53 AVLAPDYRGYGESA--------GDWGGDEVDDVLAAIDYLAARPYVDPDRIGIYGHSYGGYMALLAAARHPDRFKAAVAL 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530342 675 APITDLKLYA---SAFSERYLGMPSKEESTYQAASVLHNVHGLKEeNILIIHGTADTKVHFQHSAELIKHLIKAGVNYTM 751
Cdd:COG1506   125 AGVSDLRSYYgttREYTERLMGGPWEDPEAYAARSPLAYADKLKT-PLLLIHGEADDRVPPEQAERLYEALKKAGKPVEL 203

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1677530342 752 QVYPDEGHNVSEKSKYHLYSTILKFFSDCLK 782
Cdd:COG1506   204 LVYPGEGHGFSGAGAPDYLERILDFLDRHLK 234
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 595-781 9.39e-09

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 56.85  E-value: 9.39e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530342 595 IVARFDGRGSGF-QGLkilqeiHRRLGSVEVKDQITAVKFLLKLPYIDSKRLSIFGKGYGGYIASMILKSDEKlFKCGSV 673
Cdd:COG1073    66 NVLAFDYRGYGEsEGE------PREEGSPERRDARAAVDYLRTLPGVDPERIGLLGISLGGGYALNAAATDPR-VKAVIL 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530342 674 VAPITDLK-----LYASAFSERYLGMPSKEESTY-----QAASVLHNVHGLKeENILIIHGTADTKVHFQHSAELIKhli 743
Cdd:COG1073   139 DSPFTSLEdlaaqRAKEARGAYLPGVPYLPNVRLasllnDEFDPLAKIEKIS-RPLLFIHGEKDEAVPFYMSEDLYE--- 214

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1677530342 744 KAGVNYTMQVYPDEGHNVSEKSKYHLY-STILKFFSDCL 781
Cdd:COG1073   215 AAAEPKELLIVPGAGHVDLYDRPEEEYfDKLAEFFKKNL 253
COG4099 COG4099
Predicted peptidase [General function prediction only];
630-761 5.92e-07

Predicted peptidase [General function prediction only];


Pssm-ID: 443275 [Multi-domain]  Cd Length: 235  Bit Score: 51.51  E-value: 5.92e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530342 630 AVKFLLKLPYIDSKRLSIFGKGYGGYIA-SMILKSDEkLFKCGSVVAPITDLklyasAFSERYLGMPskeestyqaasvl 708
Cdd:COG4099   112 LLDDLIAEYRIDPDRIYLTGLSMGGYGTwDLAARYPD-LFAAAVPICGGGDP-----ANAANLKKVP------------- 172

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1677530342 709 hnvhglkeenILIIHGTADTKVHFQHSAELIKHLIKAGVNYTMQVYPDEGHNV 761
Cdd:COG4099   173 ----------VWIFHGAKDDVVPVEESRAMVEALKAAGADVKYTEYPGVGHNS 215
YpfH COG0400
Predicted esterase [General function prediction only];
640-763 5.47e-05

Predicted esterase [General function prediction only];


Pssm-ID: 440169 [Multi-domain]  Cd Length: 200  Bit Score: 44.90  E-value: 5.47e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530342 640 IDSKRLSIFGKGYGGYIASMILKSDEKLFKCgsVVApitdlklyasaFSerylGMPSKEESTYQAASVLHNVHglkeenI 719
Cdd:COG0400    86 IDPERIVLAGFSQGAAMALSLALRRPELLAG--VVA-----------LS----GYLPGEEALPAPEAALAGTP------V 142

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1677530342 720 LIIHGTADTKVHFQHSAELIKHLIKAGVNYTMQVYPDeGHNVSE 763
Cdd:COG0400   143 FLAHGTQDPVIPVERAREAAEALEAAGADVTYREYPG-GHEISP 185
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
624-759 2.72e-04

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 43.03  E-value: 2.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530342 624 VKDQITAVKFLLKLPYIDSKRLSIFGKGYGGYIAsMILKSDEKLFKCgsVVApitdlklyasafserYLGMPSKEESTYQ 703
Cdd:COG0412    90 AADLRAALDWLKAQPEVDAGRVGVVGFCFGGGLA-LLAAARGPDLAA--AVS---------------FYGGLPADDLLDL 151

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1677530342 704 AASVLHNVhglkeeniLIIHGTADTKVHFQHSAELIKHLIKAGVNYTMQVYPDEGH 759
Cdd:COG0412   152 AARIKAPV--------LLLYGEKDPLVPPEQVAALEAALAAAGVDVELHVYPGAGH 199
PLN02442 PLN02442
S-formylglutathione hydrolase
 631-759 3.07e-04

S-formylglutathione hydrolase


Pssm-ID: 178061 [Multi-domain]  Cd Length: 283  Bit Score: 43.61  E-value: 3.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530342 631 VKFLLKL-----PYIDSKRLSIFGKGYGGYIASMI-LKSDEKlFKCGSVVAPI---TDLKLYASAFSErYLGmPSKEE-S 700
Cdd:PLN02442  126 VKELPKLlsdnfDQLDTSRASIFGHSMGGHGALTIyLKNPDK-YKSVSAFAPIanpINCPWGQKAFTN-YLG-SDKADwE 202

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530342 701 TYQAASVLHNVHGLKEEnILIIHGTADTKVHFQHSAELIKHLIK-AGVNYTMQVYPDEGH 759
Cdd:PLN02442  203 EYDATELVSKFNDVSAT-ILIDQGEADKFLKEQLLPENFEEACKeAGAPVTLRLQPGYDH 261
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
596-779 2.36e-03

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 40.37  E-value: 2.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530342 596 VARFDGRGSGfqglkilqEIHRRLGSVE-----VKDQITAVKFLLKLPyidSKRLSIFGKGYGGYIASMILKSDEKLFKc 670
Cdd:COG2267    58 VLAFDLRGHG--------RSDGPRGHVDsfddyVDDLRAALDALRARP---GLPVVLLGHSMGGLIALLYAARYPDRVA- 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530342 671 gSVVapitdlkLYASAFSERYLGMPSkeESTYQAASVLHNVHGLKEEnILIIHGTADTKVHFQHSAELIKHLIKAGvnyT 750
Cdd:COG2267   126 -GLV-------LLAPAYRADPLLGPS--ARWLRALRLAEALARIDVP-VLVLHGGADRVVPPEAARRLAARLSPDV---E 191

                         170       180       190
                  ....*....|....*....|....*....|
gi 1677530342 751 MQVYPDEGHNV-SEKSKYHLYSTILKFFSD 779
Cdd:COG2267   192 LVLLPGARHELlNEPAREEVLAAILAWLER 221
PRK11460 PRK11460
putative hydrolase; Provisional
 686-759 9.79e-03

putative hydrolase; Provisional


Pssm-ID: 183144 [Multi-domain]  Cd Length: 232  Bit Score: 38.48  E-value: 9.79e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1677530342 686 AFSERYLGMPSKEestyQAASVLHnvhglkeenilIIHGTADTKVHFQHSAELIKHLIKAGVNYTMQVYPDEGH 759
Cdd:PRK11460  133 AFSGRYASLPETA----PTATTIH-----------LIHGGEDPVIDVAHAVAAQEALISLGGDVTLDIVEDLGH 191
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH