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Conserved domains on  [gi|10946594|ref|NP_067272|]
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toll-like receptor 4 precursor [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
672-813 3.16e-33

Toll - interleukin 1 - resistance;


:

Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 124.74  E-value: 3.16e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594    672 YDAFVIYSSQneDWVRNELVKNLEEGVPRFHLCLHYRDFIPGVAIAANIIqEGFHKSRKVIVVVSRHFIQSRWCIFEYEI 751
Cdd:smart00255   2 YDVFISYSGK--EDVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEID-EAIEKSRIAIVVLSPNYAESEWCLDELVA 78
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 10946594    752 AQTWQFLSSRSGIIFIVLEkVEKSLLRQQVELYRLLSRNTYLEWEDNPLGRhiFWRRLKNAL 813
Cdd:smart00255  79 ALENALEEGGLRVIPIFYE-VIPSDVRKQPGKFRKVFKKNYLKWPEDEKEQ--FWKKALYAV 137
PLN00113 super family cl33413
leucine-rich repeat receptor-like protein kinase; Provisional
46-456 1.12e-10

leucine-rich repeat receptor-like protein kinase; Provisional


The actual alignment was detected with superfamily member PLN00113:

Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 65.25  E-value: 1.12e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594   46 KVPDDI---PSSTKNIDLSFNPLKilKSYSFSNFSELQWLDLSRceiETIEDKAWHGLHHLSNLI---LTGNPIQSFSPG 119
Cdd:PLN00113 108 PIPDDIfttSSSLRYLNLSNNNFT--GSIPRGSIPNLETLDLSN---NMLSGEIPNDIGSFSSLKvldLGGNVLVGKIPN 182
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594  120 SFSGLTSLENLVAVETKLASLESFPIGQLITLKKLNVAHNFIhSCKLPAYFSNLTNLVHVDLSYNYIQTITVNDLQFLRE 199
Cdd:PLN00113 183 SLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNL-SGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKN 261
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594  200 NPQVNLSLDMSLNPIdfiQDQAFQGIKLHELTLRGNFNSSNI--MKTCLQNLAGLHVhrlilgeFKDErnleiFEPSIME 277
Cdd:PLN00113 262 LQYLFLYQNKLSGPI---PPSIFSLQKLISLDLSDNSLSGEIpeLVIQLQNLEILHL-------FSNN-----FTGKIPV 326
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594  278 GLCDVTIDEFRLTYTNDFSDDIVK-------FHCLaNVSAMSLAGVSIKYLEDVPKHFKW------------------QS 332
Cdd:PLN00113 327 ALTSLPRLQVLQLWSNKFSGEIPKnlgkhnnLTVL-DLSTNNLTGEIPEGLCSSGNLFKLilfsnslegeipkslgacRS 405
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594  333 LSIIRCQLKQFPT------LDLPFLKSLTLTMNK--GSISFKKVALPSLSYLDLSRNalSFSGCCSYSdLGTNSLRHLDL 404
Cdd:PLN00113 406 LRRVRLQDNSFSGelpsefTKLPLVYFLDISNNNlqGRINSRKWDMPSLQMLSLARN--KFFGGLPDS-FGSKRLENLDL 482
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 10946594  405 S---FNGAIIMSanFMGLEELQHLDFQHSTLKRV--TEFSaflSLEKLLYLDISYTN 456
Cdd:PLN00113 483 SrnqFSGAVPRK--LGSLSELMQLKLSENKLSGEipDELS---SCKKLVSLDLSHNQ 534
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
369-555 3.24e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd00116:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 319  Bit Score: 53.13  E-value: 3.24e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 369 ALPSLSYLDLSRNALSFSGCCSYSDLGTN-SLRHLDLSFNGaiimsanfmglEELQHLDFQHSTLKRVTEfsaflSLEKL 447
Cdd:cd00116  79 KGCGLQELDLSDNALGPDGCGVLESLLRSsSLQELKLNNNG-----------LGDRGLRLLAKGLKDLPP-----ALEKL 142
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 448 LYLDISYTNTK-IDFDGIFLGLTSLNTLKMAGNSFKDN---TLSNVFANTTNLTFLDLSKCQLE-----QISwGVFDTLH 518
Cdd:cd00116 143 VLGRNRLEGAScEALAKALRANRDLKELNLANNGIGDAgirALAEGLKANCNLEVLDLNNNGLTdegasALA-ETLASLK 221
                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 10946594 519 RLQLLNMSHNNL-----LFLDSSHYNQLYSLSTLDCSFNRIE 555
Cdd:cd00116 222 SLEVLNLGDNNLtdagaAALASALLSPNISLLTLSLSCNDIT 263
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
672-813 3.16e-33

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 124.74  E-value: 3.16e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594    672 YDAFVIYSSQneDWVRNELVKNLEEGVPRFHLCLHYRDFIPGVAIAANIIqEGFHKSRKVIVVVSRHFIQSRWCIFEYEI 751
Cdd:smart00255   2 YDVFISYSGK--EDVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEID-EAIEKSRIAIVVLSPNYAESEWCLDELVA 78
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 10946594    752 AQTWQFLSSRSGIIFIVLEkVEKSLLRQQVELYRLLSRNTYLEWEDNPLGRhiFWRRLKNAL 813
Cdd:smart00255  79 ALENALEEGGLRVIPIFYE-VIPSDVRKQPGKFRKVFKKNYLKWPEDEKEQ--FWKKALYAV 137
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
675-814 1.81e-29

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246  Cd Length: 165  Bit Score: 114.77  E-value: 1.81e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594   675 FVIYSS----QNEDWVRNELVKNLeeGVPRFHLCLHYRDFIPGVAIAANIiQEGFHKSRKVIVVVSRHFIQSRWCIFEYE 750
Cdd:pfam01582   1 YDVFLSfrgsDTREWFVSHLLKEL--KQKGIKLFIDDRDLEPGEAIAPEL-LSAIEKSRRSVVVLSPNYASSGWCLDELV 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594   751 IAQTWQfLSSRSGIIFIVLEKVEK-------SLLRQQVELYRLLSRNTYLEWE------------DNPLGRHIFWRRLKN 811
Cdd:pfam01582  78 KILECA-LDLGQKVIPIFYEVDPSdvrkqtgSFGKAFKKHKKVLTEEKVLKWRgalnevaniwhsKSVSDESKFWKKIAY 156

                  ...
gi 10946594   812 ALL 814
Cdd:pfam01582 157 DIS 159
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
46-456 1.12e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 65.25  E-value: 1.12e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594   46 KVPDDI---PSSTKNIDLSFNPLKilKSYSFSNFSELQWLDLSRceiETIEDKAWHGLHHLSNLI---LTGNPIQSFSPG 119
Cdd:PLN00113 108 PIPDDIfttSSSLRYLNLSNNNFT--GSIPRGSIPNLETLDLSN---NMLSGEIPNDIGSFSSLKvldLGGNVLVGKIPN 182
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594  120 SFSGLTSLENLVAVETKLASLESFPIGQLITLKKLNVAHNFIhSCKLPAYFSNLTNLVHVDLSYNYIQTITVNDLQFLRE 199
Cdd:PLN00113 183 SLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNL-SGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKN 261
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594  200 NPQVNLSLDMSLNPIdfiQDQAFQGIKLHELTLRGNFNSSNI--MKTCLQNLAGLHVhrlilgeFKDErnleiFEPSIME 277
Cdd:PLN00113 262 LQYLFLYQNKLSGPI---PPSIFSLQKLISLDLSDNSLSGEIpeLVIQLQNLEILHL-------FSNN-----FTGKIPV 326
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594  278 GLCDVTIDEFRLTYTNDFSDDIVK-------FHCLaNVSAMSLAGVSIKYLEDVPKHFKW------------------QS 332
Cdd:PLN00113 327 ALTSLPRLQVLQLWSNKFSGEIPKnlgkhnnLTVL-DLSTNNLTGEIPEGLCSSGNLFKLilfsnslegeipkslgacRS 405
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594  333 LSIIRCQLKQFPT------LDLPFLKSLTLTMNK--GSISFKKVALPSLSYLDLSRNalSFSGCCSYSdLGTNSLRHLDL 404
Cdd:PLN00113 406 LRRVRLQDNSFSGelpsefTKLPLVYFLDISNNNlqGRINSRKWDMPSLQMLSLARN--KFFGGLPDS-FGSKRLENLDL 482
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 10946594  405 S---FNGAIIMSanFMGLEELQHLDFQHSTLKRV--TEFSaflSLEKLLYLDISYTN 456
Cdd:PLN00113 483 SrnqFSGAVPRK--LGSLSELMQLKLSENKLSGEipDELS---SCKKLVSLDLSHNQ 534
LRR_8 pfam13855
Leucine rich repeat;
53-113 3.15e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.90  E-value: 3.15e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 10946594    53 SSTKNIDLSFNPLKILKSYSFSNFSELQWLDLSRCEIETIEDKAWHGLHHLSNLILTGNPI 113
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
369-555 3.24e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 53.13  E-value: 3.24e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 369 ALPSLSYLDLSRNALSFSGCCSYSDLGTN-SLRHLDLSFNGaiimsanfmglEELQHLDFQHSTLKRVTEfsaflSLEKL 447
Cdd:cd00116  79 KGCGLQELDLSDNALGPDGCGVLESLLRSsSLQELKLNNNG-----------LGDRGLRLLAKGLKDLPP-----ALEKL 142
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 448 LYLDISYTNTK-IDFDGIFLGLTSLNTLKMAGNSFKDN---TLSNVFANTTNLTFLDLSKCQLE-----QISwGVFDTLH 518
Cdd:cd00116 143 VLGRNRLEGAScEALAKALRANRDLKELNLANNGIGDAgirALAEGLKANCNLEVLDLNNNGLTdegasALA-ETLASLK 221
                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 10946594 519 RLQLLNMSHNNL-----LFLDSSHYNQLYSLSTLDCSFNRIE 555
Cdd:cd00116 222 SLEVLNLGDNNLtdagaAALASALLSPNISLLTLSLSCNDIT 263
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
342-547 5.70e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 227223 [Multi-domain]  Cd Length: 394  Bit Score: 52.66  E-value: 5.70e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 342 QFPTLDLPFLKSLTLTMNKGS--ISFKKVALPSLSYLDLSRNALSFSgccsYSDLGT-NSLRHLDLSFNGAIIMSANFMG 418
Cdd:COG4886 109 ISELLELTNLTSLDLDNNNITdiPPLIGLLKSNLKELDLSDNKIESL----PSPLRNlPNLKNLDLSFNDLSDLPKLLSN 184
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 419 LEELQHLDFQHSTLKRVTEFSAFLSleKLLYLDISYtNTKIDFDGIFLGLTSLNTLKMAGNSFKDntLSNVFANTTNLTF 498
Cdd:COG4886 185 LSNLNNLDLSGNKISDLPPEIELLS--ALEELDLSN-NSIIELLSSLSNLKNLSGLELSNNKLED--LPESIGNLSNLET 259
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 10946594 499 LDLSKCQLEQISwgVFDTLHRLQLLNMSHNNLLFLDSSHYNQLYSLSTL 547
Cdd:COG4886 260 LDLSNNQISSIS--SLGSLTNLRELDLSGNSLSNALPLIALLLLLLELL 306
LRR_8 pfam13855
Leucine rich repeat;
494-554 4.84e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 4.84e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 10946594   494 TNLTFLDLSKCQLEQISWGVFDTLHRLQLLNMSHNNLLFLDSSHYNQLYSLSTLDCSFNRI 554
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
73-214 1.31e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.92  E-value: 1.31e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594  73 FSNFSELQWLDLSRCEIETIEDkaWHGLHHLSNLILTGNPIQSFSpgsfsGLTSLENL---------VAVETKLASLESF 143
Cdd:cd21340  42 LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVE-----GLENLTNLeelhienqrLPPGEKLTFDPRS 114
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 10946594 144 PIGQLITLKKLNVAHNFIHScklPAYFSNLTNLVHVDLSYNYIQTI-----TVNDLQFLREnpqvnlsLDMSLNPI 214
Cdd:cd21340 115 LAALSNSLRVLNISGNNIDS---LEPLAPLRNLEQLDASNNQISDLeelldLLSSWPSLRE-------LDLTGNPV 180
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
672-813 3.16e-33

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 124.74  E-value: 3.16e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594    672 YDAFVIYSSQneDWVRNELVKNLEEGVPRFHLCLHYRDFIPGVAIAANIIqEGFHKSRKVIVVVSRHFIQSRWCIFEYEI 751
Cdd:smart00255   2 YDVFISYSGK--EDVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEID-EAIEKSRIAIVVLSPNYAESEWCLDELVA 78
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 10946594    752 AQTWQFLSSRSGIIFIVLEkVEKSLLRQQVELYRLLSRNTYLEWEDNPLGRhiFWRRLKNAL 813
Cdd:smart00255  79 ALENALEEGGLRVIPIFYE-VIPSDVRKQPGKFRKVFKKNYLKWPEDEKEQ--FWKKALYAV 137
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
675-814 1.81e-29

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246  Cd Length: 165  Bit Score: 114.77  E-value: 1.81e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594   675 FVIYSS----QNEDWVRNELVKNLeeGVPRFHLCLHYRDFIPGVAIAANIiQEGFHKSRKVIVVVSRHFIQSRWCIFEYE 750
Cdd:pfam01582   1 YDVFLSfrgsDTREWFVSHLLKEL--KQKGIKLFIDDRDLEPGEAIAPEL-LSAIEKSRRSVVVLSPNYASSGWCLDELV 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594   751 IAQTWQfLSSRSGIIFIVLEKVEK-------SLLRQQVELYRLLSRNTYLEWE------------DNPLGRHIFWRRLKN 811
Cdd:pfam01582  78 KILECA-LDLGQKVIPIFYEVDPSdvrkqtgSFGKAFKKHKKVLTEEKVLKWRgalnevaniwhsKSVSDESKFWKKIAY 156

                  ...
gi 10946594   812 ALL 814
Cdd:pfam01582 157 DIS 159
TIR_2 pfam13676
TIR domain; This is a family of bacterial Toll-like receptors.
675-770 5.98e-12

TIR domain; This is a family of bacterial Toll-like receptors.


Pssm-ID: 433398  Cd Length: 119  Bit Score: 63.12  E-value: 5.98e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594   675 FVIYSSQNEDWVRnELVKNLEE-GvprFHLCLHYRDFIPGVAIAANIiQEGFHKSRKVIVVVSRHFIQSRWCIFEYEIAQ 753
Cdd:pfam13676   2 FISYAGEDRAWAE-WLADALEAaG---YRVWLDRWDIRPGDDWVEEI-EEAIENSDRVLVVLSPAYLESPWCRAEWEAAL 76
                          90
                  ....*....|....*..
gi 10946594   754 TwQFLSSRSGIIFIVLE 770
Cdd:pfam13676  77 A-ADPEGRKRLIPVRLE 92
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
46-456 1.12e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 65.25  E-value: 1.12e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594   46 KVPDDI---PSSTKNIDLSFNPLKilKSYSFSNFSELQWLDLSRceiETIEDKAWHGLHHLSNLI---LTGNPIQSFSPG 119
Cdd:PLN00113 108 PIPDDIfttSSSLRYLNLSNNNFT--GSIPRGSIPNLETLDLSN---NMLSGEIPNDIGSFSSLKvldLGGNVLVGKIPN 182
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594  120 SFSGLTSLENLVAVETKLASLESFPIGQLITLKKLNVAHNFIhSCKLPAYFSNLTNLVHVDLSYNYIQTITVNDLQFLRE 199
Cdd:PLN00113 183 SLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNL-SGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKN 261
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594  200 NPQVNLSLDMSLNPIdfiQDQAFQGIKLHELTLRGNFNSSNI--MKTCLQNLAGLHVhrlilgeFKDErnleiFEPSIME 277
Cdd:PLN00113 262 LQYLFLYQNKLSGPI---PPSIFSLQKLISLDLSDNSLSGEIpeLVIQLQNLEILHL-------FSNN-----FTGKIPV 326
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594  278 GLCDVTIDEFRLTYTNDFSDDIVK-------FHCLaNVSAMSLAGVSIKYLEDVPKHFKW------------------QS 332
Cdd:PLN00113 327 ALTSLPRLQVLQLWSNKFSGEIPKnlgkhnnLTVL-DLSTNNLTGEIPEGLCSSGNLFKLilfsnslegeipkslgacRS 405
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594  333 LSIIRCQLKQFPT------LDLPFLKSLTLTMNK--GSISFKKVALPSLSYLDLSRNalSFSGCCSYSdLGTNSLRHLDL 404
Cdd:PLN00113 406 LRRVRLQDNSFSGelpsefTKLPLVYFLDISNNNlqGRINSRKWDMPSLQMLSLARN--KFFGGLPDS-FGSKRLENLDL 482
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 10946594  405 S---FNGAIIMSanFMGLEELQHLDFQHSTLKRV--TEFSaflSLEKLLYLDISYTN 456
Cdd:PLN00113 483 SrnqFSGAVPRK--LGSLSELMQLKLSENKLSGEipDELS---SCKKLVSLDLSHNQ 534
LRR_8 pfam13855
Leucine rich repeat;
53-113 3.15e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.90  E-value: 3.15e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 10946594    53 SSTKNIDLSFNPLKILKSYSFSNFSELQWLDLSRCEIETIEDKAWHGLHHLSNLILTGNPI 113
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
369-555 3.24e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 53.13  E-value: 3.24e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 369 ALPSLSYLDLSRNALSFSGCCSYSDLGTN-SLRHLDLSFNGaiimsanfmglEELQHLDFQHSTLKRVTEfsaflSLEKL 447
Cdd:cd00116  79 KGCGLQELDLSDNALGPDGCGVLESLLRSsSLQELKLNNNG-----------LGDRGLRLLAKGLKDLPP-----ALEKL 142
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 448 LYLDISYTNTK-IDFDGIFLGLTSLNTLKMAGNSFKDN---TLSNVFANTTNLTFLDLSKCQLE-----QISwGVFDTLH 518
Cdd:cd00116 143 VLGRNRLEGAScEALAKALRANRDLKELNLANNGIGDAgirALAEGLKANCNLEVLDLNNNGLTdegasALA-ETLASLK 221
                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 10946594 519 RLQLLNMSHNNL-----LFLDSSHYNQLYSLSTLDCSFNRIE 555
Cdd:cd00116 222 SLEVLNLGDNNLtdagaAALASALLSPNISLLTLSLSCNDIT 263
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
342-547 5.70e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 227223 [Multi-domain]  Cd Length: 394  Bit Score: 52.66  E-value: 5.70e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 342 QFPTLDLPFLKSLTLTMNKGS--ISFKKVALPSLSYLDLSRNALSFSgccsYSDLGT-NSLRHLDLSFNGAIIMSANFMG 418
Cdd:COG4886 109 ISELLELTNLTSLDLDNNNITdiPPLIGLLKSNLKELDLSDNKIESL----PSPLRNlPNLKNLDLSFNDLSDLPKLLSN 184
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 419 LEELQHLDFQHSTLKRVTEFSAFLSleKLLYLDISYtNTKIDFDGIFLGLTSLNTLKMAGNSFKDntLSNVFANTTNLTF 498
Cdd:COG4886 185 LSNLNNLDLSGNKISDLPPEIELLS--ALEELDLSN-NSIIELLSSLSNLKNLSGLELSNNKLED--LPESIGNLSNLET 259
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 10946594 499 LDLSKCQLEQISwgVFDTLHRLQLLNMSHNNLLFLDSSHYNQLYSLSTL 547
Cdd:COG4886 260 LDLSNNQISSIS--SLGSLTNLRELDLSGNSLSNALPLIALLLLLLELL 306
LRR_8 pfam13855
Leucine rich repeat;
77-130 1.22e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 1.22e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 10946594    77 SELQWLDLSRCEIETIEDKAWHGLHHLSNLILTGNPIQSFSPGSFSGLTSLENL 130
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYL 54
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
41-296 2.09e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 227223 [Multi-domain]  Cd Length: 394  Bit Score: 50.74  E-value: 2.09e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594  41 DQKLSKVPDDI--PSSTKNIDLSFNPLKILkSYSFSNFSELQWLDLSRCEIETIEDKAWHgLHHLSNLILTGNPIQSFsP 118
Cdd:COG4886 149 DNKIESLPSPLrnLPNLKNLDLSFNDLSDL-PKLLSNLSNLNNLDLSGNKISDLPPEIEL-LSALEELDLSNNSIIEL-L 225
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 119 GSFSGLTSLENLVAVETKLASLESfPIGQLITLKKLNVAHNFIHScklPAYFSNLTNLVHVDLSYNyiqtitvndlQFLR 198
Cdd:COG4886 226 SSLSNLKNLSGLELSNNKLEDLPE-SIGNLSNLETLDLSNNQISS---ISSLGSLTNLRELDLSGN----------SLSN 291
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 199 ENPQVNLSLDMSLNPIDFIQDQAFQGIKLHELTLrGNFNSSNIMKTCLQNLAGLHVHRLI--LGEFKDERNLEIFEPSIM 276
Cdd:COG4886 292 ALPLIALLLLLLELLLNLLLTLKALELKLNSILL-NNNILSNGETSSPEALSILESLNNLwtLDNALDESNLNRYIVKNP 370
                       250       260
                ....*....|....*....|..
gi 10946594 277 E--GLCDVTIDEFRLTYTNDFS 296
Cdd:COG4886 371 NaiGSLLDLVKKHVNQLLEKVN 392
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
41-214 3.67e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 227223 [Multi-domain]  Cd Length: 394  Bit Score: 46.88  E-value: 3.67e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594  41 DQKLSKVPDDIPSSTKNIDLSFNPLKILK-SYSFSNFSELQWLDLSRCEIeTIEDKAWHGLHHLSNLILTGNPIQSFSPG 119
Cdd:COG4886  56 SNTLLLLPSSLSRLLSLDLLSPSGISSLDgSENLLNLLPLPSLDLNLNRL-RSNISELLELTNLTSLDLDNNNITDIPPL 134
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 120 SFSGLTSLENLVAVETKLASLESfPIGQLITLKKLNVAHNfiHSCKLPAYFSNLTNLVHVDLSYNYIQTITVndlqfLRE 199
Cdd:COG4886 135 IGLLKSNLKELDLSDNKIESLPS-PLRNLPNLKNLDLSFN--DLSDLPKLLSNLSNLNNLDLSGNKISDLPP-----EIE 206
                       170
                ....*....|....*
gi 10946594 200 NPQVNLSLDMSLNPI 214
Cdd:COG4886 207 LLSALEELDLSNNSI 221
LRR_8 pfam13855
Leucine rich repeat;
494-554 4.84e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 4.84e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 10946594   494 TNLTFLDLSKCQLEQISWGVFDTLHRLQLLNMSHNNLLFLDSSHYNQLYSLSTLDCSFNRI 554
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
97-168 8.03e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 46.35  E-value: 8.03e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 10946594   97 WHGLHHLSNLILTGNPIQSFSPGSFSGLTSLENLVAVETKLASLESFPIGQLITLKKLNVAHNFIhSCKLPA 168
Cdd:PLN03150 438 ISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSL-SGRVPA 508
LRR_8 pfam13855
Leucine rich repeat;
490-530 9.42e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.89  E-value: 9.42e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 10946594   490 FANTTNLTFLDLSKCQLEQISWGVFDTLHRLQLLNMSHNNL 530
Cdd:pfam13855  21 FKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
73-214 1.31e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.92  E-value: 1.31e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594  73 FSNFSELQWLDLSRCEIETIEDkaWHGLHHLSNLILTGNPIQSFSpgsfsGLTSLENL---------VAVETKLASLESF 143
Cdd:cd21340  42 LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVE-----GLENLTNLeelhienqrLPPGEKLTFDPRS 114
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 10946594 144 PIGQLITLKKLNVAHNFIHScklPAYFSNLTNLVHVDLSYNYIQTI-----TVNDLQFLREnpqvnlsLDMSLNPI 214
Cdd:cd21340 115 LAALSNSLRVLNISGNNIDS---LEPLAPLRNLEQLDASNNQISDLeelldLLSSWPSLRE-------LDLTGNPV 180
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
47-162 1.57e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.14  E-value: 1.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594   47 VPDDIPSST-KNIDLSFNPLKILKSYSFSNFSELQWLDLSRCEIETIEDKAWHGLHHLSNLILTGNPIQSFSPGSFSGLT 125
Cdd:PLN00113 468 LPDSFGSKRlENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMP 547
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 10946594  126 SLENLVAVETKLASLESFPIGQLITLKKLNVAHNFIH 162
Cdd:PLN00113 548 VLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHLH 584
YjbI COG1357
Uncharacterized protein YjbI, contains pentapeptide repeats [Function unknown];
392-509 4.03e-03

Uncharacterized protein YjbI, contains pentapeptide repeats [Function unknown];


Pssm-ID: 224276 [Multi-domain]  Cd Length: 238  Bit Score: 39.86  E-value: 4.03e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 392 SDLGTNSLRHLDLSFNGAIIMSANFMGLEeLQHLDFQHSTLKRV--TEFSAF---------LSLEKLLYLDISYTNTKID 460
Cdd:COG1357  32 ADLQGSELQLGDLNFENANLSGLDLSGAN-LSGADLSNANLRGAdlSKGADLsgadleganLRGANLSGANLSGANLSNA 110
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 10946594 461 FDGIFLGlTSLNTLKMAGNSFKDNTLSNVFANTTNLTFLDLSKCQLEQI 509
Cdd:COG1357 111 TRANLSG-ADLSGANLSNANLTGANLSGANLNGANLSNANLSGADLSGA 158
LRR_8 pfam13855
Leucine rich repeat;
150-214 4.60e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 4.60e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 10946594   150 TLKKLNVAHNFIHSCKlPAYFSNLTNLVHVDLSYNYIQTITVNDLQFLRenpqvNL-SLDMSLNPI 214
Cdd:pfam13855   2 NLRSLDLSNNRLTSLD-DGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLP-----SLrYLDLSGNRL 61
YjbI COG1357
Uncharacterized protein YjbI, contains pentapeptide repeats [Function unknown];
329-512 5.38e-03

Uncharacterized protein YjbI, contains pentapeptide repeats [Function unknown];


Pssm-ID: 224276 [Multi-domain]  Cd Length: 238  Bit Score: 39.47  E-value: 5.38e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 329 KWQSLSIIRCQLKQFPTLDLPFLKSltltmNKGSISFKKVALPSLSY--LDLSRNALS---FSGC--CSYSDLGTNSLRH 401
Cdd:COG1357  15 ESSRLQGIRELKANLLGADLQGSEL-----QLGDLNFENANLSGLDLsgANLSGADLSnanLRGAdlSKGADLSGADLEG 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 402 LDLS---FNGAIIMSANFMGLEE--LQHLDFQHSTLKRVTEFSAFLSLEKLLYLDISYTN------TKIDFDGIFLGLTS 470
Cdd:COG1357  90 ANLRganLSGANLSGANLSNATRanLSGADLSGANLSNANLTGANLSGANLNGANLSNANlsgadlSGADLSGADLSGAN 169
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 10946594 471 -----LNTLKMAGNSFKDNTLSNVFANTTNLTFLDLSKCQLEQISWG 512
Cdd:COG1357 170 lsgadLRGANLSGANLSGADLRNANLSGADLSGADLTGANLVNANLG 216
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
422-554 8.65e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.61  E-value: 8.65e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946594 422 LQHLDFQHSTLKRVTEFSAFLSLEKLlYLDisytNTKI----DFDGiflgLTSLNTLKMAGNS--------FKDNTLSNV 489
Cdd:cd21340  48 LTHLYLQNNQIEKIENLENLVNLKKL-YLG----GNRIsvveGLEN----LTNLEELHIENQRlppgekltFDPRSLAAL 118
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 10946594 490 fANTtnLTFLDLSKCQLEQISWgvFDTLHRLQLLNMSHNNLLFLD--SSHYNQLYSLSTLDCSFNRI 554
Cdd:cd21340 119 -SNS--LRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGNPV 180
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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