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Conserved domains on  [gi|10946866|ref|NP_067446|]
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solute carrier organic anion transporter family member 1C1 isoform 1 [Mus musculus]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
42-582 0e+00

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17459:

Pssm-ID: 452895 [Multi-domain]  Cd Length: 498  Bit Score: 848.67  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866  42 LKVFLGALSFVYFAKALAEGYLKSTVTQIERRFEIPSSLVGIIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCLVMGF 121
Cdd:cd17459   1 LKIFLAALSFAYFAKALSGSYMKSTITQIERRFDIPSSLIGVIDGSFEMGNLLVIAFVSYFGAKLHRPRIIGAGCLLMAI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 122 GTMLIAVPQFFMEKYSYEKyeRYSPSSNVTPSISPCYLESSSPSPSsiLGKSQNKISHECVGDSSSSMWVYVFLGNLLRG 201
Cdd:cd17459  81 GTFLIALPHFFMGRYKYET--AIQSSSNSTVSISPCSLEPSPQLHS--IESSDSKTGTGCEKEPGSSMWIYVFLGNLLRG 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 202 LGETPIQPLGIAYLDDFASEDNAAFYIGCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVNLDHITITPKDPQWVGAWWLGY 281
Cdd:cd17459 157 IGETPVQPLGISYIDDFAKEENAAFYIGCVQTIAIIGPVFGFLLGSLCAKLYVDIGFVNLDSITITPKDARWVGAWWLGY 236
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 282 LIAGFLSLLAAVPFWCLPKTLPrsqsrensgstsekskfiddpihyqmapgddkmkimemaKDFLPSLKTLFRNPVYILY 361
Cdd:cd17459 237 LIAGVITLLSAVPFWFLPKSLP---------------------------------------KDFLPSLKNLLGNPVYFLY 277
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 362 LCASTVQFNSLFGMVTYKPKYIEQQYGQSSSKANFVIGLINIPAVALGIFSGGIVMKKFRLGICEATKLYLGSSVFGYLL 441
Cdd:cd17459 278 LCTSILQFNSLIGMVTYKPKYIEQQYGQSASKANFLIGLINIPAVAIGIFSGGLLMKKFKLSVIGAAKLSFGTSFFGYLL 357
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 442 FLSLFALGCENSSVAGLTVSYQGTKPVSYHERALFSDCNSRCKCSDSKWEPMCGDNGITYVSACLAGCQSSSRSGKNIIF 521
Cdd:cd17459 358 LLSFFAMGCENSDVAGLTVSYNGTKQVSYADRSLFSQCNADCKCSQKDWDPVCGENGITYVSPCLAGCKASNGSGKNTVF 437
                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 10946866 522 SNCTCVGFAAPKSGNWSGMMGRCQKDNGCSQMFLYFLVISVITSYTLSLGGIPGYILLLRC 582
Cdd:cd17459 438 HNCSCIGIPSSASGSSSAILGQCPKGNACARMFLYFLAISVISSFTLSLGGTPGYILLIRC 498
 
Name Accession Description Interval E-value
MFS_SLCO1C_OATP1C cd17459
Solute carrier organic anion transporter 1C subfamily of the Major Facilitator Superfamily of ...
42-582 0e+00

Solute carrier organic anion transporter 1C subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1C (SLCO1C), also called Organic anion-transporting polypeptide 1C (OATP1C), subfamily contains one mammalian member, OATP1C1 (encoded by SLCO1C1), which is also called thyroxine transporter. It mediates the high affinity transport of the thyroid hormones, T4 (3,5,3',5'tetraiodo-L-thyronine or thyroxine), rT3 (3,3'5'-triiodo-L-thyronine), and T3 (3,5,3'tri-iodo-L-thyronine or triiodothyronine), as well as organic anions such as 17-beta-glucuronosyl estradiol, estrone-3-sulfate, and sulfobromophthalein (BSP), which are transported with much lower efficiency. The SLCO1C/OATP1C subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341017 [Multi-domain]  Cd Length: 498  Bit Score: 848.67  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866  42 LKVFLGALSFVYFAKALAEGYLKSTVTQIERRFEIPSSLVGIIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCLVMGF 121
Cdd:cd17459   1 LKIFLAALSFAYFAKALSGSYMKSTITQIERRFDIPSSLIGVIDGSFEMGNLLVIAFVSYFGAKLHRPRIIGAGCLLMAI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 122 GTMLIAVPQFFMEKYSYEKyeRYSPSSNVTPSISPCYLESSSPSPSsiLGKSQNKISHECVGDSSSSMWVYVFLGNLLRG 201
Cdd:cd17459  81 GTFLIALPHFFMGRYKYET--AIQSSSNSTVSISPCSLEPSPQLHS--IESSDSKTGTGCEKEPGSSMWIYVFLGNLLRG 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 202 LGETPIQPLGIAYLDDFASEDNAAFYIGCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVNLDHITITPKDPQWVGAWWLGY 281
Cdd:cd17459 157 IGETPVQPLGISYIDDFAKEENAAFYIGCVQTIAIIGPVFGFLLGSLCAKLYVDIGFVNLDSITITPKDARWVGAWWLGY 236
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 282 LIAGFLSLLAAVPFWCLPKTLPrsqsrensgstsekskfiddpihyqmapgddkmkimemaKDFLPSLKTLFRNPVYILY 361
Cdd:cd17459 237 LIAGVITLLSAVPFWFLPKSLP---------------------------------------KDFLPSLKNLLGNPVYFLY 277
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 362 LCASTVQFNSLFGMVTYKPKYIEQQYGQSSSKANFVIGLINIPAVALGIFSGGIVMKKFRLGICEATKLYLGSSVFGYLL 441
Cdd:cd17459 278 LCTSILQFNSLIGMVTYKPKYIEQQYGQSASKANFLIGLINIPAVAIGIFSGGLLMKKFKLSVIGAAKLSFGTSFFGYLL 357
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 442 FLSLFALGCENSSVAGLTVSYQGTKPVSYHERALFSDCNSRCKCSDSKWEPMCGDNGITYVSACLAGCQSSSRSGKNIIF 521
Cdd:cd17459 358 LLSFFAMGCENSDVAGLTVSYNGTKQVSYADRSLFSQCNADCKCSQKDWDPVCGENGITYVSPCLAGCKASNGSGKNTVF 437
                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 10946866 522 SNCTCVGFAAPKSGNWSGMMGRCQKDNGCSQMFLYFLVISVITSYTLSLGGIPGYILLLRC 582
Cdd:cd17459 438 HNCSCIGIPSSASGSSSAILGQCPKGNACARMFLYFLAISVISSFTLSLGGTPGYILLIRC 498
OATP pfam03137
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ...
44-641 0e+00

Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.


Pssm-ID: 427161 [Multi-domain]  Cd Length: 526  Bit Score: 634.24  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866    44 VFLGALSFVYFAKALAEGYLKSTVTQIERRFEIPSSLVGIIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCLVMGFGT 123
Cdd:pfam03137   1 GFLVFLSLLGLAQALVSGYFNSSITTIEKRFGLPSSLSGLISSSYDIGNLLLILFVSYFGGKGHRPRWIGVGSLLMGLGS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866   124 MLIAVPQFFmekysyekyeryspssnvtpsispcylessspspssilgksqnkishecvgdssssmwvYVFLGNLLRGLG 203
Cdd:pfam03137  81 LLFALPHFL-----------------------------------------------------------SFFLGQLLLGIG 101
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866   204 ETPIQPLGIAYLDDFASEDNAAFYIGCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVNldhITITPKDPQWVGAWWLGYLI 283
Cdd:pfam03137 102 GTPLYTLGISYIDDNVKKKNSPLYLGILYAVRVLGPALGFLLGSLCLRIYVDIGSVS---LTLTPKDPRWVGAWWLGFLI 178
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866   284 AGFLSLLAAVPFWCLPKTLPRSQSRENSGSTSEKSKFIDDPIHyqmapgDDKMKIMEMAKDFLPSLKTLFRNPVYILYLC 363
Cdd:pfam03137 179 AGLLLLLTAIPFFFFPKSLPGTAKRRAEKKKEPESHSIKDSEK------TKSLKLGKSLKDFPRALKRLLKNPVYMLLTL 252
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866   364 ASTVQFNSLFGMVTYKPKYIEQQYGQSSSKANFVIGLINIPAVALGIFSGGIVMKKFRLGICEATKLYLGSSVFGYLLFL 443
Cdd:pfam03137 253 ASVSEFLLIAGYATFLPKYIETQFGLSASTANLLTGVVLIPGAALGILLGGLIIKKFKLSAKGLAKFNLITSLVSLLLSL 332
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866   444 SLFALGCENSSVAGLTVSYQGTKPVSyheRALFSDCNSRCKCSDSKWEPMCGDNG--ITYVSACLAGCQSSSRSGKNIIF 521
Cdd:pfam03137 333 LLFFLGCPNSPVAGITVPYGGTQQLS---GNLTASCNSNCSCSTSFYSPVCGSDGigYTSPCPCGAGCSSSSGAGKSTYN 409
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866   522 SNCTCVGFAAPKSGNWSGMMGRCqkDNGCSQMFLYFLVISVITSYTLSLGGIPGYILLLRCIQPQLKSFALGIYTLAVRV 601
Cdd:pfam03137 410 CSCCCSCGSSTSGGNGSATPGKC--PSDCSNKLPLFLALLFLASFFSSLSSTPGTLIILRCVPPEDKSFALGLQFLILRL 487
                         570       580       590       600
                  ....*....|....*....|....*....|....*....|
gi 10946866   602 LAGIPAPVYFGVLIDTSCLKWGfKKCGSRGSCRLYDSHAF 641
Cdd:pfam03137 488 LGFIPGPIIFGALIDSTCLLWT-KTCGGRGNCWLYDNDKL 526
oat TIGR00805
sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2. ...
40-669 0e+00

sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2.A.60)Proteins of the OAT family catalyze the Na+-independent facilitated transport of organic anions such as bromosulfobromophthalein and prostaglandins as well as conjugated and unconjugated bile acids (taurocholate and cholate, respectively). These transporters have been characterized in mammals, but homologues are present in C. elegans and A. thaliana. Some of the mammalian proteins exhibit a high degree of tissue specificity. For example, the rat OAT is found at high levels in liver and kidney and at lower levels in other tissues. These proteins possess 10-12 putative a-helical transmembrane spanners. They may catalyze electrogenic anion uniport or anion exchange.


Pssm-ID: 273279 [Multi-domain]  Cd Length: 632  Bit Score: 581.30  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866    40 GKLKVFLGALSFVYFAKALAEGYLKSTVTQIERRFEIPSSLVGIIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCLVM 119
Cdd:TIGR00805  29 SKIKMFSLLLTCARLQGLLVNGLVNSMLTSIERRFKIPTSRSGFINGSYEIGNLLLIIFVSYFGTKLHRPIVIGAGCAIM 108
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866   120 GFGTMLIAVPQFFMEKYSYEKyerySPSSNVTPSISPCYLesSSPSPSSILGKSQNkiSHECVGDSSSSMWVYVFLGNLL 199
Cdd:TIGR00805 109 GLGSLLSSLPHFLMGRYSYST----TVSSTGNLSSANSFL--CMENLTQTLRPTQD--PSECQKQHKSLMWLLFLVSNIL 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866   200 RGLGETPIQPLGIAYLDDFASEDNAAFYIGCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVNLDHITITPKDPQWVGAWWL 279
Cdd:TIGR00805 181 RGIGATPIFPLGISYIDDFAKSKNSPLYIGILESGSVFGPAFGFLLGSFCLQIYVDTGSVNTEDLIITPTDPRWIGAWWI 260
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866   280 GYLIAGFLSLLAAVPFWCLPKTLPRSQSRENSGST-SEKSKFIDDPihyqmapgdDKMKIMEMAKDFLPSLKTLFRNPVY 358
Cdd:TIGR00805 261 GFLVCGFVALLTSIPLFFFPKTLPKEGKRVNVDVHeAEKLEKSRGE---------DRKKNSGITKDFPKFIKRLLCNKIY 331
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866   359 ILYLCASTVQFNSLFGMVTYKPKYIEQQYGQSSSKANFVIGLINIPAVALGIFSGGIVMKKFRLGICEATKLYLGSSVFG 438
Cdd:TIGR00805 332 MLVILAQVIDVLAFNGYITFLPKYLENQYGISSAEANLLIGVVNVPPIGLGYLIGGFIMKKFKLNVKKAAYFAICLSTLE 411
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866   439 YLLFLSLFALGCENSSVAGLTV-SYQGTKPVsyherALFSDCNSRCKCSDSKWEPMCGDNGITYVSACLAGCQSSSRSGK 517
Cdd:TIGR00805 412 YLLYSPKFLITCESAPVAGVNNpSNDQPLYV-----ENRTDCNRQCSCDSSIWDPVCGDNGLAYLSPCHAGCRMSVGTGS 486
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866   518 NIIFSNCTCVgfaaPKSGNWSGMMGRCqkDNGCSQMFLYFLVISVITSYTLSLGGIPGYILLLRCIQPQLKSFALGIYTL 597
Cdd:TIGR00805 487 NMVFTNCSCI----QTPGNSSAKKGLC--DPPCATSLQYFLILFIPLSFIYFITAVPGYMVLLRCVKSEERSLGLGLQWF 560
                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 10946866   598 AVRVLAGIPAPVYFGVLIDTSCLKWGFKKCGSRGSCRLYDSHAFRHIYLGLTTLLGTVSVFLSMAVLFVLKK 669
Cdd:TIGR00805 561 CIRVFGTIPAPILFGALIDVTCLHWQTLKCGASGACRMYDNDNLRVIYLGLTIALRGSSLLPLFFILILARK 632
 
Name Accession Description Interval E-value
MFS_SLCO1C_OATP1C cd17459
Solute carrier organic anion transporter 1C subfamily of the Major Facilitator Superfamily of ...
42-582 0e+00

Solute carrier organic anion transporter 1C subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1C (SLCO1C), also called Organic anion-transporting polypeptide 1C (OATP1C), subfamily contains one mammalian member, OATP1C1 (encoded by SLCO1C1), which is also called thyroxine transporter. It mediates the high affinity transport of the thyroid hormones, T4 (3,5,3',5'tetraiodo-L-thyronine or thyroxine), rT3 (3,3'5'-triiodo-L-thyronine), and T3 (3,5,3'tri-iodo-L-thyronine or triiodothyronine), as well as organic anions such as 17-beta-glucuronosyl estradiol, estrone-3-sulfate, and sulfobromophthalein (BSP), which are transported with much lower efficiency. The SLCO1C/OATP1C subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341017 [Multi-domain]  Cd Length: 498  Bit Score: 848.67  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866  42 LKVFLGALSFVYFAKALAEGYLKSTVTQIERRFEIPSSLVGIIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCLVMGF 121
Cdd:cd17459   1 LKIFLAALSFAYFAKALSGSYMKSTITQIERRFDIPSSLIGVIDGSFEMGNLLVIAFVSYFGAKLHRPRIIGAGCLLMAI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 122 GTMLIAVPQFFMEKYSYEKyeRYSPSSNVTPSISPCYLESSSPSPSsiLGKSQNKISHECVGDSSSSMWVYVFLGNLLRG 201
Cdd:cd17459  81 GTFLIALPHFFMGRYKYET--AIQSSSNSTVSISPCSLEPSPQLHS--IESSDSKTGTGCEKEPGSSMWIYVFLGNLLRG 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 202 LGETPIQPLGIAYLDDFASEDNAAFYIGCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVNLDHITITPKDPQWVGAWWLGY 281
Cdd:cd17459 157 IGETPVQPLGISYIDDFAKEENAAFYIGCVQTIAIIGPVFGFLLGSLCAKLYVDIGFVNLDSITITPKDARWVGAWWLGY 236
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 282 LIAGFLSLLAAVPFWCLPKTLPrsqsrensgstsekskfiddpihyqmapgddkmkimemaKDFLPSLKTLFRNPVYILY 361
Cdd:cd17459 237 LIAGVITLLSAVPFWFLPKSLP---------------------------------------KDFLPSLKNLLGNPVYFLY 277
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 362 LCASTVQFNSLFGMVTYKPKYIEQQYGQSSSKANFVIGLINIPAVALGIFSGGIVMKKFRLGICEATKLYLGSSVFGYLL 441
Cdd:cd17459 278 LCTSILQFNSLIGMVTYKPKYIEQQYGQSASKANFLIGLINIPAVAIGIFSGGLLMKKFKLSVIGAAKLSFGTSFFGYLL 357
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 442 FLSLFALGCENSSVAGLTVSYQGTKPVSYHERALFSDCNSRCKCSDSKWEPMCGDNGITYVSACLAGCQSSSRSGKNIIF 521
Cdd:cd17459 358 LLSFFAMGCENSDVAGLTVSYNGTKQVSYADRSLFSQCNADCKCSQKDWDPVCGENGITYVSPCLAGCKASNGSGKNTVF 437
                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 10946866 522 SNCTCVGFAAPKSGNWSGMMGRCQKDNGCSQMFLYFLVISVITSYTLSLGGIPGYILLLRC 582
Cdd:cd17459 438 HNCSCIGIPSSASGSSSAILGQCPKGNACARMFLYFLAISVISSFTLSLGGTPGYILLIRC 498
MFS_SLCO1_OATP1 cd17400
Solute carrier organic anion transporter 1 family of the Major Facilitator Superfamily of ...
42-581 0e+00

Solute carrier organic anion transporter 1 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1 (SLCO1) or Organic anion transporting polypeptide 1 (OATP1) family contains three subfamilies: OATP1A, OATP1B, and OATP1C. OATP1A contains one human member, OATP1A2, which shows a broad spectrum of substrates including endogenous compounds (such as bile acids, steroid hormones and their conjugates, thyroid hormones) and various drugs (such as fexofenadine, ouabain and the cyanobacterial toxin microcystin). OATP1B contains two human proteins, OATP1B1 and OATP1B3, which can both accept a wide variety of structurally-unrelated compounds as substrates including clinically-important drugs such as hydroxymethylglutaryl (HMG)-CoA reductase inhibitors (statins), angiotensin II receptor blockers (sartans), angiotensin converting enzyme (ACE) inhibitors, and anti-diabetes drugs (glinides). OATP1C contains one mammalian member, OATP1C1, which is also called thyroxine transporter. It mediates the high affinity transport of the thyroid hormones, T4 (3,5,3',5'tetraiodo-L-thyronine or thyroxine), rT3 (3,3'5'-triiodo-L-thyronine), and T3 (3,5,3'tri-iodo-L-thyronine or triiodothyronine). The SLCO1/OATP1 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340958 [Multi-domain]  Cd Length: 436  Bit Score: 681.56  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866  42 LKVFLGALSFVYFAKALAEGYLKSTVTQIERRFEIPSSLVGIIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCLVMGF 121
Cdd:cd17400   1 LKMFLLALSCAFVAKTLSGSYMKSMITQIERRFNIPSSLVGFIDGSFEIGNLLVIIFVSYFGTKLHRPKMIGIGCVIMGL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 122 GTMLIAVPQFFMEKYSYekyeryspssnvtpsispcylessspspssilgksqnkishecvgdssSSMWVYVFLGNLLRG 201
Cdd:cd17400  81 GCFLKALPHFFMNQYEY------------------------------------------------SLMWIYVFVGNILRG 112
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 202 LGETPIQPLGIAYLDDFASEDNAAFYIGCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVNLDHITITPKDPQWVGAWWLGY 281
Cdd:cd17400 113 IGETPILPLGISYIDDFAKEENSPLYIGLVETGAIIGPIIGFLLGSLCAKVYVDIGFVNLDDIIITPTDTRWVGAWWLGF 192
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 282 LIAGFLSLLAAVPFWCLPktlprsqsrensgstsekskfiddpihyqmapgddkmkimemakdflpslktlfrnPVYILY 361
Cdd:cd17400 193 LICGGVSVLTAIPFFFLP--------------------------------------------------------PIYMLF 216
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 362 LCASTVQFNSLFGMVTYKPKYIEQQYGQSSSKANFVIGLINIPAVALGIFSGGIVMKKFRLGICEATKLYLGSSVFGYLL 441
Cdd:cd17400 217 ILVSVIQFNSFVGMITYMPKYLEQQYGQSSSDANFLMGIINIPPIAIGYFIGGLIMKKFKITVKGAAKIGCWLSVLEYLL 296
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 442 FLSLFALGCENSSVAGLTVSYQGTKPVSYHERALFSDCNSRCKCSDSKWEPMCGDNGITYVSACLAGCQSSSRSGKNIIF 521
Cdd:cd17400 297 YLLSFLMTCENSSVAGLTTSYEGIPPVLYHENDIFSDCNSDCNCPEKIWEPVCGNNGITYLSACLAGCETSIGTGKNIVF 376
                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 522 SNCTCVGFAAPKSGNWSGMMGRCQKDNGCSQMFLYFLVISVITSYTLSLGGIPGYILLLR 581
Cdd:cd17400 377 YNCSCIQTSGNSSANLSLCDGGCPRDPDCSLMFQYFLIISVMSSFIYSLGGIPGYMLLLR 436
OATP pfam03137
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ...
44-641 0e+00

Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.


Pssm-ID: 427161 [Multi-domain]  Cd Length: 526  Bit Score: 634.24  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866    44 VFLGALSFVYFAKALAEGYLKSTVTQIERRFEIPSSLVGIIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCLVMGFGT 123
Cdd:pfam03137   1 GFLVFLSLLGLAQALVSGYFNSSITTIEKRFGLPSSLSGLISSSYDIGNLLLILFVSYFGGKGHRPRWIGVGSLLMGLGS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866   124 MLIAVPQFFmekysyekyeryspssnvtpsispcylessspspssilgksqnkishecvgdssssmwvYVFLGNLLRGLG 203
Cdd:pfam03137  81 LLFALPHFL-----------------------------------------------------------SFFLGQLLLGIG 101
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866   204 ETPIQPLGIAYLDDFASEDNAAFYIGCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVNldhITITPKDPQWVGAWWLGYLI 283
Cdd:pfam03137 102 GTPLYTLGISYIDDNVKKKNSPLYLGILYAVRVLGPALGFLLGSLCLRIYVDIGSVS---LTLTPKDPRWVGAWWLGFLI 178
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866   284 AGFLSLLAAVPFWCLPKTLPRSQSRENSGSTSEKSKFIDDPIHyqmapgDDKMKIMEMAKDFLPSLKTLFRNPVYILYLC 363
Cdd:pfam03137 179 AGLLLLLTAIPFFFFPKSLPGTAKRRAEKKKEPESHSIKDSEK------TKSLKLGKSLKDFPRALKRLLKNPVYMLLTL 252
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866   364 ASTVQFNSLFGMVTYKPKYIEQQYGQSSSKANFVIGLINIPAVALGIFSGGIVMKKFRLGICEATKLYLGSSVFGYLLFL 443
Cdd:pfam03137 253 ASVSEFLLIAGYATFLPKYIETQFGLSASTANLLTGVVLIPGAALGILLGGLIIKKFKLSAKGLAKFNLITSLVSLLLSL 332
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866   444 SLFALGCENSSVAGLTVSYQGTKPVSyheRALFSDCNSRCKCSDSKWEPMCGDNG--ITYVSACLAGCQSSSRSGKNIIF 521
Cdd:pfam03137 333 LLFFLGCPNSPVAGITVPYGGTQQLS---GNLTASCNSNCSCSTSFYSPVCGSDGigYTSPCPCGAGCSSSSGAGKSTYN 409
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866   522 SNCTCVGFAAPKSGNWSGMMGRCqkDNGCSQMFLYFLVISVITSYTLSLGGIPGYILLLRCIQPQLKSFALGIYTLAVRV 601
Cdd:pfam03137 410 CSCCCSCGSSTSGGNGSATPGKC--PSDCSNKLPLFLALLFLASFFSSLSSTPGTLIILRCVPPEDKSFALGLQFLILRL 487
                         570       580       590       600
                  ....*....|....*....|....*....|....*....|
gi 10946866   602 LAGIPAPVYFGVLIDTSCLKWGfKKCGSRGSCRLYDSHAF 641
Cdd:pfam03137 488 LGFIPGPIIFGALIDSTCLLWT-KTCGGRGNCWLYDNDKL 526
MFS_SLCO1A_OATP1A cd17458
Solute carrier organic anion transporter 1A subfamily of the Major Facilitator Superfamily of ...
41-582 0e+00

Solute carrier organic anion transporter 1A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1A (SLCO1A), also called Organic anion-transporting polypeptide 1A (OATP1A), subfamily is composed of one human member OATP1A2 (encoded by SLCO1A2) and several rodent proteins encoded by the Slco1a1, Slco1a3, Slco1a4, Slco1a5, and Slco1a6 genes. OATP1A2, also known as human OATP-A or OATP1, shows a broad spectrum of substrates including endogenous compounds (such as bile acids, steroid hormones and their conjugates, thyroid hormones) and various drugs (such as fexofenadine, ouabain and the cyanobacterial toxin microcystin). It is expressed in the brain, kidney, intestine, liver, lung, testes, and the eye (ciliary body). The SLCO1A/OATP1A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341016 [Multi-domain]  Cd Length: 527  Bit Score: 619.18  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866  41 KLKVFLGALSFVYFAKALAEGYLKSTVTQIERRFEIPSSLVGIIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCLVMG 120
Cdd:cd17458   1 KLKIFLLALSYAYVAKTLSGAYMNSMITQIERRFNIPSSLVGIINGSFEIGNLLVIAFVSYFGAKLHRPKVIGLGCLIMS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 121 FGTMLIAVPQFFMEKYSYEKyeRYSPSSNVTPSISPCYLESSspspssiLGKSQNKISHECVGDSSSSMWVYVFLGNLLR 200
Cdd:cd17458  81 LGCFLASLPHFLMGRYEYES--TVSTTSNSSSRVPLCLANQS-------LSHNVTQLPSECEKESMSLMWIFVLVGNLLR 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 201 GLGETPIQPLGIAYLDDFASEDNAAFYIGCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVNLDHITITPKDPQWVGAWWLG 280
Cdd:cd17458 152 GIGETPVMPLGISYIDDFSKKENSPFYIGCLHTATIVGPLLGLLLASFCAQLYVDLGSVNADDLTITPTDIRWVGAWWLG 231
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 281 YLIAGFLSLLAAVPFWCLPKTLPRsQSRENSGSTSEKSKFIDDPIHYQMApgddKMKIMEMAKDFLPSLKTLFRNPVYIL 360
Cdd:cd17458 232 FLICAGVNFLAGLPFWFLPKSLPK-EGEENETEPSKTLTVELEENKGQET----KQEMYEIAKDFLPFLKSLFRNPIYML 306
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 361 YLCASTVQFNSLFGMVTYKPKYIEQQYGQSSSKANFVIGLINIPAVALGIFSGGIVMKKFRLGICEATKLYLGSSVFGYL 440
Cdd:cd17458 307 FIIVTVLQFNAFSGMISFMPKYLEQQYGKSASDAIFLIGVYNLPIICLGYFFGGLYMKKFKINTYQAAHIGFWVSLLEYL 386
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 441 LFLSLFALGCENSSVAGLTVSYQGTKPVSYHERALFSDCNSRCKCSDSKWEPMCGDNGITYVSACLAGCQSSSRSGKNII 520
Cdd:cd17458 387 LYFSAFWMGCDNSPVAGLTVSYEGIDQDSYYENTLLADCNRDCDCPLKVWDPVCGNNGLTYVSACLAGCKASVGTGKNMV 466
                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 10946866 521 FSNCTCVGfAAPKSGNWSGMMGRCQKDNGCSQMFLYFLVISVITSYTLSLGGIPGYILLLRC 582
Cdd:cd17458 467 FQNCSCVA-ASGFPSQNSSAVGQCDKGETCDKMLQYFLILSLVCSFIFSLAAMPGYMVLIRS 527
oat TIGR00805
sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2. ...
40-669 0e+00

sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2.A.60)Proteins of the OAT family catalyze the Na+-independent facilitated transport of organic anions such as bromosulfobromophthalein and prostaglandins as well as conjugated and unconjugated bile acids (taurocholate and cholate, respectively). These transporters have been characterized in mammals, but homologues are present in C. elegans and A. thaliana. Some of the mammalian proteins exhibit a high degree of tissue specificity. For example, the rat OAT is found at high levels in liver and kidney and at lower levels in other tissues. These proteins possess 10-12 putative a-helical transmembrane spanners. They may catalyze electrogenic anion uniport or anion exchange.


Pssm-ID: 273279 [Multi-domain]  Cd Length: 632  Bit Score: 581.30  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866    40 GKLKVFLGALSFVYFAKALAEGYLKSTVTQIERRFEIPSSLVGIIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCLVM 119
Cdd:TIGR00805  29 SKIKMFSLLLTCARLQGLLVNGLVNSMLTSIERRFKIPTSRSGFINGSYEIGNLLLIIFVSYFGTKLHRPIVIGAGCAIM 108
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866   120 GFGTMLIAVPQFFMEKYSYEKyerySPSSNVTPSISPCYLesSSPSPSSILGKSQNkiSHECVGDSSSSMWVYVFLGNLL 199
Cdd:TIGR00805 109 GLGSLLSSLPHFLMGRYSYST----TVSSTGNLSSANSFL--CMENLTQTLRPTQD--PSECQKQHKSLMWLLFLVSNIL 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866   200 RGLGETPIQPLGIAYLDDFASEDNAAFYIGCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVNLDHITITPKDPQWVGAWWL 279
Cdd:TIGR00805 181 RGIGATPIFPLGISYIDDFAKSKNSPLYIGILESGSVFGPAFGFLLGSFCLQIYVDTGSVNTEDLIITPTDPRWIGAWWI 260
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866   280 GYLIAGFLSLLAAVPFWCLPKTLPRSQSRENSGST-SEKSKFIDDPihyqmapgdDKMKIMEMAKDFLPSLKTLFRNPVY 358
Cdd:TIGR00805 261 GFLVCGFVALLTSIPLFFFPKTLPKEGKRVNVDVHeAEKLEKSRGE---------DRKKNSGITKDFPKFIKRLLCNKIY 331
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866   359 ILYLCASTVQFNSLFGMVTYKPKYIEQQYGQSSSKANFVIGLINIPAVALGIFSGGIVMKKFRLGICEATKLYLGSSVFG 438
Cdd:TIGR00805 332 MLVILAQVIDVLAFNGYITFLPKYLENQYGISSAEANLLIGVVNVPPIGLGYLIGGFIMKKFKLNVKKAAYFAICLSTLE 411
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866   439 YLLFLSLFALGCENSSVAGLTV-SYQGTKPVsyherALFSDCNSRCKCSDSKWEPMCGDNGITYVSACLAGCQSSSRSGK 517
Cdd:TIGR00805 412 YLLYSPKFLITCESAPVAGVNNpSNDQPLYV-----ENRTDCNRQCSCDSSIWDPVCGDNGLAYLSPCHAGCRMSVGTGS 486
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866   518 NIIFSNCTCVgfaaPKSGNWSGMMGRCqkDNGCSQMFLYFLVISVITSYTLSLGGIPGYILLLRCIQPQLKSFALGIYTL 597
Cdd:TIGR00805 487 NMVFTNCSCI----QTPGNSSAKKGLC--DPPCATSLQYFLILFIPLSFIYFITAVPGYMVLLRCVKSEERSLGLGLQWF 560
                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 10946866   598 AVRVLAGIPAPVYFGVLIDTSCLKWGFKKCGSRGSCRLYDSHAFRHIYLGLTTLLGTVSVFLSMAVLFVLKK 669
Cdd:TIGR00805 561 CIRVFGTIPAPILFGALIDVTCLHWQTLKCGASGACRMYDNDNLRVIYLGLTIALRGSSLLPLFFILILARK 632
MFS_SLCO1B_OATP1B cd17457
Solute carrier organic anion transporter 1B subfamily of the Major Facilitator Superfamily of ...
42-581 0e+00

Solute carrier organic anion transporter 1B subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1B (SLCO1B), also called organic anion-transporting polypeptide 1B (OATP1B), subfamily is composed of two human proteins, OATP1B1 (encoded by SLCO1B1) and OATP1B3 (encoded by SLCO1B3), and one rodent member, OATP1B2 (encoded by Slco1b2). OATP1B1 and OATP1B3 are almost exclusively expressed on the basal side of hepatocytes in normal human organs. They both can accept a wide variety of structurally-unrelated compounds as substrates including clinically-important drugs such as hydroxymethylglutaryl (HMG)-CoA reductase inhibitors (statins), angiotensin II receptor blockers (sartans), angiotensin converting enzyme (ACE) inhibitors, and anti-diabetes drugs (glinides). Loss-of-function mutations in both SLCO1B1 and SLCO1B3 genes result in the Rotor syndrome, a hereditary hyperbilirubinemia. The SLCO1B/OATP1B subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341015 [Multi-domain]  Cd Length: 455  Bit Score: 573.33  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866  42 LKVFLGALSFVYFAKALAEGYLKSTVTQIERRFEIPSSLVGIIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCLVMGF 121
Cdd:cd17457   1 LKMFLAALSFSYFAKALSGIIMKSSITQIERRFDISSSTVGFIDGSFEIGNLLVIAFVSYFGAKLHRPKLIAAGCFIMGL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 122 GTMLIAVPQFFMEKYSYEkyeryspssnvtpsispcylessspspssilgksqnkisheCVGDSSSSMWVYVFLGNLLRG 201
Cdd:cd17457  81 GSVLTALPHFFMGYYKYG-----------------------------------------CLKESGSYMWVYVLMGNMLRG 119
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 202 LGETPIQPLGIAYLDDFASEDNAAFYIGCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVNLDHITITPKDPQWVGAWWLGY 281
Cdd:cd17457 120 IGETPIVPLGISYLDDFAKEENSPLYLACLHTIAMIGPMIGFTLGSLFAKLYVDIGFVDLSTIRITPQDSRWVGAWWLGF 199
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 282 LIAGFLSLLAAVPFWCLPktlprsqsrensgstsekskfiddpihyqmapgddkmkimemakDFLPSLKTLFRNPVYILY 361
Cdd:cd17457 200 LVSGLFSIISAIPFFFLP--------------------------------------------GFFQSLKSILTNRLYVMF 235
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 362 LCASTVQFNSLFGMVTYKPKYIEQQYGQSSSKANFVIGLINIPAVALGIFSGGIVMKKFRLGICEATKLYLGSSVFGYLL 441
Cdd:cd17457 236 VCLTLLQVSSFIGFFTYKPKYMEQQYGQSSSKANFLLGVITLPIFASGMFLGGYIMKKYKLNTVGAAKFACFTSVMALSF 315
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 442 FLSLFALGCENSSVAGLTVSYQGTKPVSYHERALFSDCNSRCKCSDSKWEPMCGDNGITYVSACLAGCQSSSRSGKNIIF 521
Cdd:cd17457 316 YLLYFFIGCENKSVAGITMTYDGNNPVTSHRDVILSYCNSDCNCDESQWDPVCGNNGITYISACLAGCKSSSGNGKPIVF 395
                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 522 SNCTCVGFAAPKSGNWSGMMGRCQKDNGCSQMFLYFLVISVITSYTLSLGGIPGYILLLR 581
Cdd:cd17457 396 HNCSCLEVTGSQNRNYSAHLGECPRDDDCSRMFYFYVVIQVLNLFFSALGGTSAYMLIVK 455
MFS_SLCO_OATP cd17336
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ...
42-581 1.79e-126

Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340894 [Multi-domain]  Cd Length: 411  Bit Score: 381.97  E-value: 1.79e-126
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866  42 LKVFLGALSFVYFAKALAEGYLKSTVTQIERRFEIPSSLVGIIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCLVMGF 121
Cdd:cd17336   1 PKVFVVLLCLLGLLQGAVVSYFVSTITTIEKRFGLSSSQSGLILSANDIGQLLAVLLVSYFGGRGHRPRWIGIGSILMGL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 122 GTMLIAVPQFFmekysyekyeryspssnvtpsispcylessspspssilgksqnkishecvgdssssmwvyvFLGNLLRG 201
Cdd:cd17336  81 GCFLLALPHFL-------------------------------------------------------------FVGQFLLG 99
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 202 LGETPIQPLGIAYLDDFASEDNAAFYIGCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVNldhITITPKDPQWVGAWWLGY 281
Cdd:cd17336 100 IGSSPLYTLGITYIDDNVSKKNSPLYIGILYAMRVLGPALGFLLGSFLLRIYVDFSRVP---LGITPDDPRWIGAWWLGF 176
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 282 LIAGFLSLLAAVPFWCLPktlprsqsrensgstsekskfiddpihyqmapgddkmkimemakdflpslktlfrnPVYILY 361
Cdd:cd17336 177 LILGILLLIVSIPLFFFP--------------------------------------------------------PIFILL 200
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 362 LCASTVQFNSLFGMVTYKPKYIEQQYGQSSSKANFVIGLINIPAVALGIFSGGIVMKKFRLGICEATKLYLGSSVFGYLL 441
Cdd:cd17336 201 LLAIVFESFAISGFSTFLPKYLETQFRLSASLASLLTGLILVPGAALGILLGGLIIKKFKLTARGLAKFVLILSLLSVIL 280
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 442 FLSLFALGCENSSVAGLTVSYQGTKPVSYheralfSDCNSRCKCSDSKWEPMCGDNGITYVSACLAGCQSSSRSGKNIIF 521
Cdd:cd17336 281 YISLFFLGCDNPPIAGVTTPYGSSSSPIT------SSCNSDCNCSDSSFSPVCGSDGITYFSPCHAGCTSSDAGNGTKTY 354
                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 522 SNCTCVGfaaPKSGNWSGMMGRCQKDNGCSQMFLYFLVISVITSYTLSLGGIPGYILLLR 581
Cdd:cd17336 355 SNCSCIN---SGTATSSGCPPDCSVAPNCCSKLIPFLAVLFLSSFLLSLSIVPSTMITLR 411
MFS_SLCO2A_OATP2A cd17461
Solute carrier organic anion transporter 2A subfamily of the Major Facilitator Superfamily of ...
42-581 1.37e-106

Solute carrier organic anion transporter 2A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2A (SLCO2A), also called Organic anion-transporting polypeptide 2A (OATP2A), subfamily has one mammalian member, OATP2A1 (encoded by SLCO2A1), which is also called prostaglandin transporter. It is a lactate/prostaglandin anion exchanger that mediates the release of newly synthesized prostaglandins (PGD2, PGE1, PGE2, PGF2A and PGI2) from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. Mutations in SLCO2A1 can cause primary hypertrophic osteoarthropathy (PHO), a rare multi-organic disease characterized by digital clubbing, pachydermia and periosteal reaction. The SLCO2A/OATP2A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341019 [Multi-domain]  Cd Length: 474  Bit Score: 332.93  E-value: 1.37e-106
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866  42 LKVFLGALSFVYFAKALAEGYLKSTVTQIERRFEIPSSLVGIIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCLVMGF 121
Cdd:cd17461   2 IKVFVLCHGLLQLSQLLYSAYFKSSLTTIEKRFGLSSLSSGLISSLHEIGNAVLIIFVSYFGSRVHRPRLIGIGGLLLAL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 122 GTMLIAVPQFFMEKYSYekyeryspssnvtpsispcylessspspssilgksqnkishecvgdsssSMWVYVFLGNLLRG 201
Cdd:cd17461  82 GAFLLTLPHFLSEPYQY-------------------------------------------------SMWVLMVVAQLLAG 112
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 202 LGETPIQPLGIAYLDDFASEDNAAFYIGCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVNLDHITITPKDPQWVGAWWLGY 281
Cdd:cd17461 113 IGTVPIQPFGISYVDDFAEPSNSPLYIAILFAISVFGPAFGYLLGSVVLRIFVDIGRVNTATVELTPADPRWIGAWWLGL 192
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 282 LIAGFLSLLAAVPFWCLPKTLPRSQSRENSGSTSEKSKfiddpihyqmAPGDDKMKIMEMAKDFLPSLKTLFRNPVYILY 361
Cdd:cd17461 193 LISSGLLVLTSLPYFFFPREMLVGKKPSPEGDMLRKKE----------DEKKEEGSLLDFIKRFPKMFVKLLLNPLFMLL 262
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 362 LCASTVQFNSLFGMVTYKPKYIEQQYGQSSSKANFVIGLINIPAVALGIFSGGIVMKKFRLGICEATKLYLGSSVFGYLL 441
Cdd:cd17461 263 VLAQCTFSSVIAGLSTFLNKFLEKQYGASASYANFLIGAVNLPAAALGMLLGGIIMKRFGFSLRAIPRFSVVILSISIML 342
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 442 FLSLFALGCENSSVAGLtvsYQGTKPVSYHERAlfsDCNSRCKCSDSKWEPMCGDNGITYVSACLAGCQSS---SRSGKN 518
Cdd:cd17461 343 CVPLFFMGCSTQDVAGV---YPKTSNSSDGPHL---SCSANCSCPESAFNPVCGENGIEYISPCHAGCTNSnmdSSTYRQ 416
                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 10946866 519 IIFSNCTCVgfaAPKSGNWSGMMGRCQkdNGCSQMFLYFLVISVITSYTLSLGGIPGYILLLR 581
Cdd:cd17461 417 QIYSNCSCI---PDLSGEKPAKTGSCP--NSCSHLLLPVMFLISFAGLIACLTHNPLYMMVLR 474
MFS_SLCO2B_OATP2B cd17460
Solute carrier organic anion transporter 2B subfamily of the Major Facilitator Superfamily of ...
42-581 3.78e-105

Solute carrier organic anion transporter 2B subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2B (SLCO2B), also called Organic anion-transporting polypeptide 2B (OATP2B), subfamily has one mammalian member, OATP2B1 (encoded by SLCO2B1). It mediates the Na(+)-independent transport of various organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost. It also mediates the transport of endogenous sex steroid conjugates such as dehydroepiandrosterone sulfate (DHEAS). SLCO2B1 variations result in differential expression and uptake of DHEAS, which impacts subsequent resistance to androgen-deprivation therapy (ADT), the primary treatment of metastatic prostate cancer. The SLCO2B/OATP2B subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341018 [Multi-domain]  Cd Length: 479  Bit Score: 329.04  E-value: 3.78e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866  42 LKVFLGALSFVYFAKALAEGYLKSTVTQIERRFEIPSSLVGIIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCLVMGF 121
Cdd:cd17460   1 IKFFVLCHGLLQLSQLLVSGYLKSSISTIEKRFGLSSQTSGLLASFNEVGNTVLIVFVSYFGSRVHRPRFIGCGAILVSL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 122 GTMLIAVPQFFMEKYSYekyeryspssnvtpsispcylessspspssilgksqnkishecvgdssssmwVYVFLGNLLRG 201
Cdd:cd17460  81 AGFLMALPHFISEPYEY----------------------------------------------------GILFLGQLLLG 108
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 202 LGETPIQPLGIAYLDDFASEDNAAFYIGCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVNLDHITITPKDPQWVGAWWLGY 281
Cdd:cd17460 109 IGGVPIQPFGISYIDDFASESNSPLYLGILFAVTVLGPGFGFMLGSAMLRFYVDIDKMSEDEISLEIGDPRWVGAWWLGF 188
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 282 LIAGFLSLLAAVPFWCLPKTLPRSQSREN-SGSTSEKSKFIDDPIHYQMAPgddKMKIMEMAKDFLPSLKTLFRNPVYIL 360
Cdd:cd17460 189 LIAATLVALSAVPYFFFPREMPKEVVELQpREKKLAKTMLKKLKSLSDILQ---NLSLLQFIKKFPRILLRTLRNPIYLL 265
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 361 YLCASTVQFNSLFGMVTYKPKYIEQQYGQSSSKANFVIGLINIPAVALGIFSGGIVMKKFRLGICEATKLYLGSSVFGYL 440
Cdd:cd17460 266 VVLAQVNLSAMVAGLATFMGKFLERQFSITASFANLMIGGLNIPSAMVGIVVGGVILKRLQLTVRGCGAMCVLGMLLCLF 345
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 441 LFLSLFALGCENSSVAGLTVSYQgtkpvSYHERALFSDCNSRCKCSDSKWEPMCGDNGITYVSACLAGCQSSS---RSGK 517
Cdd:cd17460 346 FALPLLFIGCSTQKIAGITHRTS-----SSPGLELSSQCSEACSCPPEAFNPVCGSDGVEYISPCHAGCKSVNvqaLDNS 420
                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 10946866 518 NIIFSNCTCVGfaapkSGNWSGMMGRCQKDNGCSQMFLYFLVISVITSYTLSLGGIPGYILLLR 581
Cdd:cd17460 421 VVNYTDCSCVS-----EGGPVGAASPGTCGSGCSHLLVPFMLLVSLGGFLASLSHTPSFMLILR 479
MFS_SLCO5_OATP5 cd17404
Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of ...
43-581 3.51e-99

Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 5 (SLCO5) or Organic anion transporting polypeptide 5 (OATP5) family contains only one subfamily, OATP5A, which contains only one mammalian member OATP5A1 (encoded by SLCO5A1). Deletion of the SLCO5A1 gene has been implicated in the pathogenesis of Mesomelia-synostoses syndrome (MSS), a rare autosomal-dominant disorder characterized by mesomelic limb shortening, acral synostoses, and multiple congenital malformations. OATP5A1 may be a non-classical OATP which is involved in biological processes that require the reorganization of the cell shape, such as differentiation and migration. It seems to affect intracellular transport of drugs and may participate in chemoresistance of small cell lung cancer (SCLC by sequestration), rather than mediating cellular uptake. The SLCO5/OATP5 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340962 [Multi-domain]  Cd Length: 425  Bit Score: 311.59  E-value: 3.51e-99
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866  43 KVFLGALSFVYFAK-ALAEGYLKSTVTQIERRFEIPSSLVGIIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCLVMGF 121
Cdd:cd17404   1 KAFLVCMCLLIFIQsALSSGYLNSVITTIEKRYSLKSSESGLIVSSYEIGSLLTVVFVSYFGGRGHRPRWIAVGGVLIAL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 122 GTMLIAVPQFFMekysyekyeryspssnvtpsispcylessspspssilgksqnkishecvgdssssmwvyvfLGNLLRG 201
Cdd:cd17404  81 GSFLFSLPHFFI-------------------------------------------------------------LAQILIG 99
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 202 LGETPIQPLGIAYLDDFASEDNAAFYIGCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVNLDhitITPKDPQWVGAWWLGY 281
Cdd:cd17404 100 MGGTPIFTLGTTYLDDHVKKESSSLYLAIMYVMGALGPAAGFLLGGLLINFYVDPLSTPPD---ISPGDPRWIGAWWGGF 176
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 282 LIAGFLSLLAAVPFWCLPKtlprsqsrensgstsekskfiddpihyqmapgddkmkimemakdflpslktlfrnPVYILY 361
Cdd:cd17404 177 LLCGIALLLVAFPFFTFPK-------------------------------------------------------MTFLVV 201
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 362 LCASTVQFNSLFGMVTYKPKYIEQQYGQSSSKANFVIGLINIPAVALGIFSGGIVMKKFRLGICEATKLYLGSSVFGYLL 441
Cdd:cd17404 202 SLGYCMELAIVSGFITFLPKYLETQFGIPASNANIFTGVIAVPGAGIGIVLGGYILKRFKLGPKGAAKLALICNFLSLLL 281
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 442 FLSLFALGCENSSVAGLTVSYQ-GTKPVSYHERALFSDCNSRCKCSDSKWEPMCGDNGITYVSACLAGC-QSSSRSGKNI 519
Cdd:cd17404 282 FLTLFFLGCESIKLAGITIPYTtGPSLSSTHGRNLTSECNVNCGCSINEYEPVCGSDGITYFSPCLAGCtSVGNTSTGIR 361
                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 10946866 520 IFSNCTCVGFAAPKSGNWSGMMGRCQ--KDNGCSQMFLYFLVISVITSYTLSLGGIPGYILLLR 581
Cdd:cd17404 362 NYTNCACLQSRSSISPPTVGQGSQLQagPCSRTCNTLIPFLILLFIVTLITACAQMPALMITLR 425
MFS_SLCO2_OATP2 cd17401
Solute carrier organic anion transporter 2 family of the Major Facilitator Superfamily of ...
42-581 1.97e-94

Solute carrier organic anion transporter 2 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2 (SLCO2) or Organic anion transporting polypeptide 2 (OATP2) family contains two subfamilies: OATP2A and OATP2B, each containing one mammalian member, OATP2A1 and OATP2B1, respectively. OATP2A1 (encoded by SLCO2A1) is a lactate/prostaglandin anion exchanger that mediates the release of newly synthesized prostaglandins (PGD2, PGE1, PGE2, PGF2A and PGI2) from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. OATP2B1 (encoded by SLCO2B1) mediates the Na(+)-independent transport of various organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost, as well as endogenous sex steroid conjugates such as dehydroepiandrosterone sulfate (DHEAS). The SLCO2/OATP2 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340959 [Multi-domain]  Cd Length: 440  Bit Score: 299.84  E-value: 1.97e-94
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866  42 LKVFLGALSFVYFAKALAEGYLKSTVTQIERRFEIPSSLVGIIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCLVMGF 121
Cdd:cd17401   1 IKVFVLCHGLLQLCQLLYSGYLKSSITTIEKRFGLSSSSSGLLASFNEVGNTILIVFVSYFGSRVHRPRLIGIGGLFLAA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 122 GTMLIAVPQFFMEKYSYEkyeryspssnvtpsispcylessspspssilgksqnkishecvgdssssmwvYVFLGNLLRG 201
Cdd:cd17401  81 GAFLLTLPHFISEPYQYG----------------------------------------------------IMVVAQLLLG 108
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 202 LGETPIQPLGIAYLDDFASEDNAAFYIGCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVNLDHITITPKDPQWVGAWWLGY 281
Cdd:cd17401 109 IGGVPIQPFGISYIDDFAEPSNSPLYLGILFAVTVFGPAFGYLLGSVMLRLYVDIGRMNTAAVNLVPGDPRWIGAWWLGF 188
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 282 LIAGFLSLLAAVPFWCLPKTLprsqsrensgstsekskfiddpihyqmapgddkmkimemaKDFLPSLKTLFRNPVYILY 361
Cdd:cd17401 189 LIAAALLVLTSFPYFFFPRFI----------------------------------------KRFPCIFLRTLRNPIFLLV 228
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 362 LCASTVQFNSLFGMVTYKPKYIEQQYGQSSSKANFVIGLINIPAVALGIFSGGIVMKKFRLGICEATKLYLGSSVFGYLL 441
Cdd:cd17401 229 VLAQVTLSSMIAGLATFLNKFLEKQFGTTASYANFLIGAVNLPSAALGILFGGVLMKRLVLSLQAIPAICTTIITISMIF 308
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 442 FLSLFALGCENSSVAGLTvsYQGTkpvSYHERALFSDCNSRCKCSDSKWEPMCGDNGITYVSACLAGCQ----SSSRSGK 517
Cdd:cd17401 309 CVPLFFIGCSTPTIAGVY--PPSS---SSSIHPQSPACRRDCSCPDSIFNPVCGDNGVEYLSPCHAGCSninmSTSATSK 383
                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 10946866 518 NIIFSNCTCVgfaapKSGNWSGMMGRCqkDNGCSQMFLYFLVISVITSYTLSLGGIPGYILLLR 581
Cdd:cd17401 384 QVIYTNCSCV-----TGGSASAKTGSC--PSPCSHLLLPFIFLISLVSLIACLSHTPSFMMILR 440
MFS_SLCO3_OATP3 cd17402
Solute carrier organic anion transporter 3 family of the Major Facilitator Superfamily of ...
42-581 3.71e-91

Solute carrier organic anion transporter 3 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 3 (SLCO3) or Organic anion transporting polypeptide 3 (OATP3) family contains only one subfamily, OATP3A, which contains only one mammalian member OATP3A1 (encoded by SLCO3A1). It mediates the Na(+)-independent transport of organic anions such as estrone-3-sulfate, prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123, and vasopressin. SLCO3A1 has been identified as a Crohn's disease (CD)-associated gene, which mediates inflammatory processes in intestinal epithelial cells through NF-kappaB transcription activation, resulting in a higher incidence of bowel perforation in CD patients. The SLCO3/OATP3 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340960 [Multi-domain]  Cd Length: 444  Bit Score: 291.45  E-value: 3.71e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866  42 LKVFLGALSFVYFAKALAEGYLKSTVTQIERRFEIPSSLVGIIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCLVMGF 121
Cdd:cd17402   1 IKIFLVSECALMLAQGTVGAYLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMAL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 122 GTMLIAVPQFFMEKYSyekyeryspssnvtpsispcylessspspssilgksqnkishecvgdsSSSMWVYVFLGNLLRG 201
Cdd:cd17402  81 GALLSALPEFLTHQYK------------------------------------------------TNMMYLLLIGAQVLLG 112
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 202 LGETPIQPLGIAYLDDFASEDNAAFYIGCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVNLDHITITPKDPQWVGAWWLGY 281
Cdd:cd17402 113 IGATPVQPLGVSYIDDHVRRKDSSLYIGILFTMLVFGPACGFILGSFCTKIYVDAVFIDTSKLDITPDDPRWIGAWWGGF 192
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 282 LIAGFLSLLAAVPFWCLPKTLprSQSRensgstsekskfiddpihyqmapgddkmkimemakdFLPSL-KTLFRNPVYIL 360
Cdd:cd17402 193 LLCGALLFFSALLMFGFPQSL--QQLR------------------------------------VIPKVtKHLLSNPVFTC 234
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 361 YLCASTVQFNSLFGMVTYKPKYIEQQYGQSSSKANFVIGLINIPAVALGIFSGGIVMKKFRLGICEATKLYLGSSVFGYL 440
Cdd:cd17402 235 IVLAACMEIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTA 314
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 441 LFLSLFALGCENSSVAGLTVSYqGTKPVSYHERALFSDCNSRCKCSDSKWEPMCGDNGITYVSACLAGCQSSSRSGknii 520
Cdd:cd17402 315 CYVSFLFLGCDTGPVAGVTVPY-GNDTAPGSSLDPYAPCNSNCECQTDSFSPVCGADGITYLSACFAGCSSTNLSG---- 389
                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 10946866 521 fsnCTCVGFAAPKsgNWSGMMGRCQKDnGCSQMFLYFLVISVITSYTLSLGGIPGYILLLR 581
Cdd:cd17402 390 ---CACLSSVPAE--NATVVPGKCPSP-GCQEAFLTFLCVMCVCSMIGAMAQTPSVIILIR 444
MFS_SLCO4_OATP4 cd17403
Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of ...
43-581 8.32e-87

Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4 (SLCO4) or Organic anion transporting polypeptide 4 (OATP4) family contains two families: OATP4A and OATP4C, each containing one mammalian member, OATP4A1 and OATP4C1, respectively. OATP4A1 (encoded by SLCO4A1), is ubiquitously expressed and mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4C1 (encoded by SLCO4C1) is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate, cAMP, and uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs). The SLCO4/OATP4 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340961 [Multi-domain]  Cd Length: 420  Bit Score: 279.14  E-value: 8.32e-87
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866  43 KVFLGALS-FVYFAKALAEGYLKSTVTQIERRFEIPSSLVGIIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCLVMGF 121
Cdd:cd17403   2 KGFLFFLCiFAFLQGMVVNGFVNVSITTIEKRFGLTSTQTGLIASSYDIASVLLLLFVSYFGGRGHKPRWLGIGAFIMGI 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 122 GTMLIAVPQFFMekysyekyeryspssnvtpsispcylessspspssilgksqnkishecvgdssssmwvyVFLGNLLRG 201
Cdd:cd17403  82 GSLVFALPHFTV-----------------------------------------------------------FILAQLLHG 102
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 202 LGETPIQPLGIAYLDDFASEDNAAFYIGCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVNLDhITITPKDPQWVGAWWLGY 281
Cdd:cd17403 103 AGATPLYTLGVTYLDENVSTKMSPLYIGIFYAMAILGPAIGYVLGGFLLNLYTDIDQVDSE-LGLTPDDPRWVGAWWLGF 181
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 282 LIAGFLSLLAAVPFWCLPKTlprsqsrensgstsekskfiddpihyqmapgddkmkimemakdflpslktlfrnpvYILY 361
Cdd:cd17403 182 LISGALALIIAFPLLGFPPT--------------------------------------------------------FMFL 205
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 362 LCASTVQFNSLFGMVTYKPKYIEQQYGQSSSKANFVIGLINIPAVALGIFSGGIVMKKFRLGICEATKLYLGSSVFGYLL 441
Cdd:cd17403 206 NLAGASEGMLLAGFATFLPKLIESQFSLSASLAALLVGVVVVPGGILGTFLGGLIVKKLKLKCKGILKFCIVCSIVAFLF 285
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 442 FLSLFaLGCENSSVAGLTVSYQGTKpvSYHERALFSDCNSRCKCSDSKWEPMCGDNGITYVSACLAGCQSSSRSGKNIIF 521
Cdd:cd17403 286 SFILL-IYCPNAPFAGVTVPYGNSP--LEGTSNLTSTCNADCHCSEDFYDPVCGSDGVTYYSPCHAGCTTSHGDDGQKVY 362
                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 10946866 522 SNCTCVgfaAPKSGNWSG--MMGRCQKDNGCSQMFLYFLVISVITSYTLsLGGIPGYILLLR 581
Cdd:cd17403 363 SNCSCI---QSNSSKTSTaaTGKACPCETCCQKLYLFLAVFFLLIVFTF-MSSTPALSATLR 420
MFS_SLCO4A_OATP4A cd17462
Solute carrier organic anion transporter 4A subfamily of the Major Facilitator Superfamily of ...
44-581 2.38e-71

Solute carrier organic anion transporter 4A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4A (SLCO4A), also called Organic anion-transporting polypeptide 4A (OATP4A), subfamily has one mammalian member, OATP4A1 (encoded by SLCO4A1). It is ubiquitously expressed and it mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4A1 is the most abundantly expressed transporter colorectal cancer (CRC) and its role in the transport of estrone sulfate, which is used in hormone replacement therapy (HRT), affects the outcome of the treatment. The SLCO4A/OATP4A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341020 [Multi-domain]  Cd Length: 427  Bit Score: 238.58  E-value: 2.38e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866  44 VFLGALSFVyfAKALAEGYLKSTVTQIERRFEIPSSLVGIIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCLVMGFGT 123
Cdd:cd17462   6 FFLCAASFL--QGMTVNGFINTVITSIERRFDLRSYQSGLIASSYDIAACLCLTFVSYFGGSGHKPRWLGWGVLIMGLGS 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 124 MLIAVPQF--FMekysyekyeryspssnvtpsispcylessspspssilgksqnkishecvgdssssmwvyvfLGNLLRG 201
Cdd:cd17462  84 LVFALPHFtvFM-------------------------------------------------------------LGQFLHG 102
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 202 LGETPIQPLGIAYLDDFASEDNAAFYIGCVQTVAIIGPIFGFLLGSLCAKLYVDIGfvnlDHITITPKDPQWVGAWWLGY 281
Cdd:cd17462 103 IGATPLYTLGVTYLDENVKSNYSPVYIGIFYTAAIVGPAAGYLLGGFFLNIYTEIG----RQTELTPENPLWVGAWWIGF 178
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 282 LIAGFLSLLAAVPFWCLPKTLPrsqsrensgstsekskfiddpihyqmapgddkmkimemakdflpslkTLFRNPVYILY 361
Cdd:cd17462 179 LGAGAAALLIALPILGYPRQLP-----------------------------------------------GLLKNPTFIFL 211
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 362 LCASTVQFNSLFGMVTYKPKYIEQQYGQSSSKANFVIGLINIPAVALGIFSGGIVMKKFRLGICEATKLYLGSSVFGyLL 441
Cdd:cd17462 212 CLAGATEATLIAGMSTFGPKFLESQFSLSASEAATLFGYLVVPAGGGGTFLGGFIVNKLKLRCSGIIKFCLICTVVS-LL 290
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 442 FLSLFALGCENSSVAGLTVSYQGTKPVSYHERaLFSDCNSRCKCSDSKWEPMCGDNGITYVSACLAGCQSSSRSGKN--I 519
Cdd:cd17462 291 AIFIFSLHCPNVPMAGVTASYRGSVLPEGSLN-LTALCNADCRCLEEIYSPVCGADGLMYYSPCHAGCSEAYSDIRNgqK 369
                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 10946866 520 IFSNCTCVgfaaPKSGNWS-GMMGRCQKDNGCSQMFLYFLVISVITSYTLsLGGIPGYILLLR 581
Cdd:cd17462 370 VYQDCSCV----AGNLSVGfGEASAGKCTSNCNHMPLLLAFVFLVILFTF-LCSIPALTATLR 427
MFS_SLCO4C_OATP4C cd17463
Solute carrier organic anion transporter 4C subfamily of the Major Facilitator Superfamily of ...
61-581 5.87e-67

Solute carrier organic anion transporter 4C subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4C (SLCO4C), also called Organic anion-transporting polypeptide 4C (OATP4C), subfamily has one mammalian member, OATP4C1 (encoded by SLCO4C1). It is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAMP. It is the only OATP expressed at the basolateral side of proximal tubular cells in human kidney and it mediates the excretion of uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs) and cause further progression of renal damage and cardiovascular diseases. Overexpression of human SLCO4C1 in rat kidney promotes the renal excretion of uremic toxins and reduces hypertension, cardiomegaly, and renal inflammation in renal failure. The SLCO4C/OATP4C subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341021 [Multi-domain]  Cd Length: 429  Bit Score: 226.93  E-value: 5.87e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866  61 GYLKSTVTQIERRFEIPSSLVGIIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCLVMGFGTMLIAVPQFFmekysyek 140
Cdd:cd17463  21 GLVNISISTIEKRYELSSSLTGLISSSYDISFCLLSLFVSFYGERGHKPRWLAFSAFMIGLGSLVFSLPHFF-------- 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 141 yeryspssnvtpsispcylessspspssilgksqnkishecvgdssssmwvyVF-LGNLLRGLGETPIQPLGIAYLDDFA 219
Cdd:cd17463  93 ----------------------------------------------------VFiLGQLLLGVGGTPLYTLGTAYIDDSV 120
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 220 SEDNAAFYIGCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVnlDHITITPKDPQWVGAWWLGYLIAGFLSLLAAVPFWCLP 299
Cdd:cd17463 121 PTHKSSLYIGIGYGMSVLGPAIGYLLGGQLLNIYIDVNKG--QSVDLTEEDPRWLGAWWIGFLMCWLIAWCLIAPFSCFP 198
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 300 KTLPrsqsrensgstsekskfiddpihyqmapgddkmkimemakdflpslkTLFRNPVYILYLCASTVQFNSLFGMVTYK 379
Cdd:cd17463 199 KHLP-----------------------------------------------GLLKNPVFMCLTISSCSEALITTGFATFL 231
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 380 PKYIEQQYGQSSSKANFVIGLINIPAVALGIFSGGIVMKKFRLGICEATKLYLGSSVFGyLLFLSLFALG-CENSSVAGL 458
Cdd:cd17463 232 PKFIENQFGQTSSFAAILGGLVLIPGAAIGQILGGIIVSKFKLKCKNMIKFAIITTTVS-LLLLSVFIFAkCGNDPFAGV 310
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 459 TVSYQGTKPVSyherALFSDCNSRCKCSDSKWEPMCGDNGITYVSACLAGCQSSSRSGKNIIFSNCTCVGFAAPK-SGNW 537
Cdd:cd17463 311 SETYNGTGKIG----NLTAPCNANCSCLSSFYYPVCGADGVQYFSPCFAGCTNENLHDKKKVYYNCSCIGNFTEEfSANT 386
                       490       500       510       520
                ....*....|....*....|....*....|....*....|....*.
gi 10946866 538 SGMMGRCQKDNGCSQM--FLYFLVISVITSYtlsLGGIPGYILLLR 581
Cdd:cd17463 387 TKCEEGKKCETTCKNLpiFLCFFFFVVIFTF---MTSTPITVAILR 429
MFS_SLCO6_OATP6 cd17405
Solute carrier organic anion transporter 6 family of the Major Facilitator Superfamily of ...
61-581 4.37e-33

Solute carrier organic anion transporter 6 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 6 (SLCO6) or Organic anion transporting polypeptide 6 (OATP6) family contains only one subfamily, OATP6A, which contains only one human member OATP6A1 (encoded by SLCO6A1). The OATP6 family is the most diverged of the OATPs. OATP6A1 is also called cancer/testis antigen 48 (CT48) or gonad-specific transporter. It is strongly expressed only in normal testis, and weakly in spleen, brain, fetal brain, and placenta. It is found in tumor samples (lung, bladder, and esophageal) and cancer cell lines (lung), and may be of potential use as a target for therapy for a variety of tumor types. The SLCO6/OATP6 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340963 [Multi-domain]  Cd Length: 428  Bit Score: 132.28  E-value: 4.37e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866  61 GYLKSTVTQIERRFEIPSSLVGIIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCLVMGFGTMLIAVPQFfmekysyek 140
Cdd:cd17405  20 GLVDMSIGIFQVQFSLTRTEKYLLDFSYDISSFLVAIIIAHYGSRGNRTRWIAASCFLMGLGSMLFAFPFF--------- 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 141 yeryspssnvtpsispcylessspspssilgksqnkishecvgdssssmwVYVFLGNLLRGLGETPIQPLGIAYLDDFAS 220
Cdd:cd17405  91 --------------------------------------------------TFHIAGQCIQGIAGMPIYILGITFIFDNIP 120
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 221 EDNAAFYIGCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVNldhITITPKDPQWVGAWWLGYLIAGFLSLLAAVPFWCLPK 300
Cdd:cd17405 121 TSSAGIYLGIAHSAYLIGYLLGYVGGLPNFQPPPNEKSVE---IEVNKVYQLWQSGWWKTFLIAAAIAWCTSFPLVCFPT 197
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 301 TLPrsqsrensgstsekskfiddpihyqmapgddkmkimemakdflpslkTLFRNPVYILYLCASTVQFNSLFGMVTYKP 380
Cdd:cd17405 198 SLP-----------------------------------------------GLLKNPLLLCQAICKATEYLTFIGALEFLP 230
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 381 KYIEQQYGQSSSKANFVIGLINIPAVALGIFSGGIVMKKFRLGICEATKLYLGSSVFGYLLFLSLFALGCENSSVAGLTV 460
Cdd:cd17405 231 HYLENQFLLTPGIASLLTGAFLIPGGAIGHFLGGLIVSRLEMSCKNKMRFILVTSVISLGLFVLIFFVECQTVTFAGINE 310
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 461 SYQGTKPVSyherALFSDCNSRCKCSDSKWEPMCGDNGITYVSACLAGCQSSSRSGKNIIFSNCTCV--GFAAPKSGN-- 536
Cdd:cd17405 311 DYDGYGQLG----NLTAPCNEYCDCTSSLYTSICGRDEIEYFSPCFAGCKASKVSNTEKTYYNCSCIkeGLAAADDEGdf 386
                       490       500       510       520
                ....*....|....*....|....*....|....*....|....*
gi 10946866 537 WSGMMGRCQKDNGCSQMFLYFLVISVITSytlSLGGIPGYILLLR 581
Cdd:cd17405 387 IDAIAGKCDSKCYKLPLFFAFYFSATVFS---NMCSIPIILIILR 428
KAZAL_SLC21 cd01330
The kazal-type serine protease inhibitor domain has been detected in an extracellular loop ...
475-528 1.20e-23

The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a member of the superfamily of kazal-like proteinase inhibitors and follistatin-like proteins.


Pssm-ID: 238650 [Multi-domain]  Cd Length: 54  Bit Score: 94.29  E-value: 1.20e-23
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 10946866 475 LFSDCNSRCKCSDSKWEPMCGDNGITYVSACLAGCQSSSRSGKNIIFSNCTCVG 528
Cdd:cd01330   1 LTSSCNSNCSCSESAYSPVCGENGITYFSPCHAGCTNSTGSGGSKIYTNCSCVG 54
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
49-449 4.00e-13

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 71.69  E-value: 4.00e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866  49 LSFVYFAKALAEGYLKSTVTQIERRFEIPSSLVGIIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCLVMGFGTMLIAV 128
Cdd:cd06174   1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 129 pqffmekysyekyeryspssnvtpsispcylessspspssilgksqnkishecvgdssSSMWVYVFLGNLLRGLGETPIQ 208
Cdd:cd06174  81 ----------------------------------------------------------APSFWLLLLGRFLLGLGSGLID 102
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 209 PLGIAYLDDFASEDNAAFYIGCVQTVAIIGPIFGFLLGSLCAKLYvdigfvnldhititpkdpqwVGAWWLGYLIAGFLS 288
Cdd:cd06174 103 PAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSL--------------------GFGWRAVFLIAAALA 162
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 289 LLAAVPFWCLPKTLPRSQSRENSGSTSekskfiddpihyqmapgddkmkimemaKDFLPSLKTLFRNPVYILYLCASTVQ 368
Cdd:cd06174 163 LLAAILLLLVVPDPPESARAKNEEASS---------------------------KSVLKLLKRVLKNPGLWLLLLAIFLV 215
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 369 FNSLFGMVTYKPKYIEQQYGQSSSKANFVIGLINIpAVALGIFSGGIVMKKFRlgiceATKLYLGSSVFGYLLFLSLFAL 448
Cdd:cd06174 216 NLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGL-AGALGSLLLGLLSDRLI-----GRKPLLLIGLLLMALGLALLLL 289

                .
gi 10946866 449 G 449
Cdd:cd06174 290 A 290
Kazal_2 pfam07648
Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. ...
480-526 1.31e-11

Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors. Kazal domains often occur in tandem arrays. Small alpha+beta fold containing three disulphides.


Pssm-ID: 400135  Cd Length: 50  Bit Score: 59.81  E-value: 1.31e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 10946866   480 NSRCKCSDSKWEPMCGDNGITYVSAC---LAGCQSSSRSGKNIIFSNCTC 526
Cdd:pfam07648   1 NCNCQCPKTEYEPVCGSDGVTYPSPCalcAAGCKLGKEVKEEKVKYDGSC 50
KAZAL_FS cd00104
Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit ...
485-526 6.25e-08

Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the cognate enzyme as substrate. The reactive site peptide bond is a combining loop which has an identical conformation in all Kazal inhibitors and in all enzyme/inhibitor complexes. These Kazal domains (small hydrophobic core of alpha/beta structure with 3 to 4 disulfide bonds) often occur in tandem arrays. Similar domains are also present in follistatin (FS) and follistatin-like family members, which play an important role in tissue specific regulation. The FS domain consists of an N-terminal beta hairpin (FOLN/EGF-like domain) and a Kazal-like domain and has five disulfide bonds. Although the Kazal-like FS substructure is similar to Kazal proteinase inhibitors, no FS domain has yet been shown to be a proteinase inhibitor. Follistatin-like family members include SPARC, also known as, BM-40 or osteonectin, the Gallus gallus Flik protein, as well as, agrin which has a long array of FS domains. The kazal-type inhibitor domain has also been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The distant homolog, Ascidian trypsin inhibitor, is included in this CD.


Pssm-ID: 238052 [Multi-domain]  Cd Length: 41  Bit Score: 49.19  E-value: 6.25e-08
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 10946866 485 CSDSkWEPMCGDNGITYVSACLAGCQSSSRSGKNIIFSNCTC 526
Cdd:cd00104   1 CPKE-YDPVCGSDGKTYSNECHLGCAACRSGRSITVAHNGPC 41
MFS_1 pfam07690
Major Facilitator Superfamily;
49-458 9.69e-07

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 51.26  E-value: 9.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866    49 LSFVYFAKALAEGYLKSTVTQ-IERRFEIPSSLVGIIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCLVMGFGTMLIA 127
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866   128 VpqffmekysyekyeryspssnvtpsispcylessspspssilgksqnkishecvgdsSSSMWVYVFLGnLLRGLGETPI 207
Cdd:pfam07690  81 F---------------------------------------------------------ASSLWLLLVLR-VLQGLGAGAL 102
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866   208 QPLGIAYLDDFASEDNAAFYIGCVQTVAIIGPIFGFLLGSLCAKLYvdigfvnldhititpkDPQWVgawwlgYLIAGFL 287
Cdd:pfam07690 103 FPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF----------------GWRAA------FLILAIL 160
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866   288 SLLAAVPFWclpKTLPRSQSRENSGStsekskfiddpihyqmapgddkmkimEMAKDFLPSLKTLFRNPVYILYLCASTV 367
Cdd:pfam07690 161 SLLAAVLLL---LPRPPPESKRPKPA--------------------------EEARLSLIVAWKALLRDPVLWLLLALLL 211
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866   368 QFNSLFGMVTYKPKYIEqQYGQSSSKANFVIGLINIPAVALGIFSGGIVmkkFRLGICEATKLYLGSSVFGYLLFLSLFA 447
Cdd:pfam07690 212 FGFAFFGLLTYLPLYQE-VLGLSALLAGLLLGLGGLLGAIGRLLLGRLS---DRLGRRRRLLLALLLLILAALGLLLLSL 287
                         410
                  ....*....|.
gi 10946866   448 LGCENSSVAGL 458
Cdd:pfam07690 288 TLSSLWLLLAL 298
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
201-456 3.22e-05

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 46.85  E-value: 3.22e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 201 GLGETPIQPLGIAYLDDFASEDNAAFYIGcVQTVAI-IGPIFGFLLGSLCAklyvdigfvnldhititpkdpQWVGAWWL 279
Cdd:cd17328  98 GIGEASYSPIAPTIIADLFPKEKRTRALG-VFYFAIpLGSGLGYVVGGLVA---------------------QATGGWRW 155
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 280 GYLIAGFLSLLAAVPFWCLPKTLPRSQSRENSGSTSEKSKFIDDpihyqmapgddkmkimemakdflpsLKTLFRNPVYI 359
Cdd:cd17328 156 AFRVTGVLGVLLAILLLLFVREPPRGAAEGGVMAKSTATSFLAD-------------------------LKALAKNPSFI 210
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 360 LY-LCASTVQFnSLFGMVTYKPKYIEQQYG---QSSSKANFVIGLINIPAVALGIFSGGIVMKKFRLGICEATKLYLGSS 435
Cdd:cd17328 211 LStLGFTAVSF-VTGALAFWAPTFFLRAFGvgdLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRKTPRADPLVCAVG 289
                       250       260
                ....*....|....*....|.
gi 10946866 436 VFGYLLFLSLFALGCENSSVA 456
Cdd:cd17328 290 LLAAAPFLFLALVLALSNLLL 310
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
190-447 5.03e-05

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 46.03  E-value: 5.03e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 190 WVYVFLGNLLRGLGETPIQPLGIAYLDDFASEDNAAFYIGCVQTVAIIGPIFGFLLGSLcakLYvdigfvnldhititpk 269
Cdd:cd17325  84 YWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGL---LA---------------- 144
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 270 dpQWVGAWWLgYLIAGFLSLLAAVP-FWCLPKTLPRSQSRENsgstsekskfiddpihyqmapgddkmkimeMAKDFLPS 348
Cdd:cd17325 145 --DALGYRAP-FLVCAALALLALVLaLLLLPEPRPPPNKRAV------------------------------SAARLRSG 191
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 349 LKTLFRNPvYILYLCASTVQFNSLFGMV-TYKPKYIEQQYGQSSSKANFVIGLINIPAVALGIFSGGIVMKKFRLGIcea 427
Cdd:cd17325 192 LRLLLRDR-RLLALFLAIFVLAFAFGALePFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPL--- 267
                       250       260
                ....*....|....*....|
gi 10946866 428 tkLYLGSSVFGYLLFLSLFA 447
Cdd:cd17325 268 --ILIGLLLSAVALLLLPLA 285
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
198-446 1.81e-03

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 41.19  E-value: 1.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866   198 LLRGLGETPIQPLGIAYLDDFASEDNAAFYIGCVQTVAIIGPIFGFLLGSLCAKLYvdigfvnldhititpkdpqwvgAW 277
Cdd:TIGR00895 113 FLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVF----------------------GW 170
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866   278 WLGYLIAGFLSLLAAVPFWclpKTLPRS---QSRENSGSTSEKSKFIDDPIHYQ----MAPGDDKMKIMEMAKDFLPSLK 350
Cdd:TIGR00895 171 RSLFYVGGIAPLLLLLLLM---RFLPESidfLVSKRPETVRRIVNAIAPQMQAEaqsaLPEQKSTQGTKRSVFKALFQGK 247
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866   351 TLFRNPvyILYLCASTVQFnSLFGMVTYKPKYIEQQyGQSSSKANFVIGLINIpAVALGIFSGGIVMKKFRLGIceATKL 430
Cdd:TIGR00895 248 TARITV--LLWLLYFMLLV-GVYFLTNWLPKLMVEL-GFSLSLAATGGALFNF-GGVIGSIIFGWLADRLGPRV--TALL 320
                         250
                  ....*....|....*.
gi 10946866   431 YLGSSVFGYLLFLSLF 446
Cdd:TIGR00895 321 LLLGAVFAVLVGSTLF 336
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
186-449 2.01e-03

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 41.00  E-value: 2.01e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 186 SSSMWVyVFLGNLLRGLGETPIQPLGIAYLDDFASEDNAAFYIGCVQTVAIIGPIFGFLLGSLCAklyvdigfvnldhit 265
Cdd:cd17324  84 APSFAL-LLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLG--------------- 147
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 266 itpkdpQWVGaWWLGYLIAGFLSLLAAVPFWclpKTLPRSQSRENsgstsekskfiddpihyqmapgddkmkimeMAKDF 345
Cdd:cd17324 148 ------QLLG-WRAAFLAIAVLALLAALLLW---RLLPSLPPKKP------------------------------GSLGL 187
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10946866 346 LPSLKTLFRNPVYILYLCASTVQFNSLFGMVTYKPKYIEQQYGQSSSKANFVIGLINIpAVALGIFSGGIVMKKFRLGIc 425
Cdd:cd17324 188 LSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGV-AGVVGSPLAGRLADRGGRRA- 265
                       250       260
                ....*....|....*....|....
gi 10946866 426 eatkLYLGSSVFGYLLFLSLFALG 449
Cdd:cd17324 266 ----LLIALLLLAAALLLLTLLGP 285
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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