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Conserved domains on  [gi|27883866|ref|NP_068751|]
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synembryn-A isoform 1 [Homo sapiens]

Protein Classification

synembryn( domain architecture ID 10562755)

synembryn is a guanine nucleotide exchange factor (GEF) which promotes exchange of bound GDP for free GTP, similar to human synembryn-A (also known as Ric-8A) and synembryn-B (also known as Ric-8B)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ric8 pfam10165
Guanine nucleotide exchange factor synembryn; Ric8 is involved in the EGL-30 neurotransmitter ...
 67-499 4.32e-137

Guanine nucleotide exchange factor synembryn; Ric8 is involved in the EGL-30 neurotransmitter signalling pathway. It is a guanine nucleotide exchange factor that regulates neurotransmitter secretion.


:

Pssm-ID: 462973  Cd Length: 412  Bit Score: 403.12  E-value: 4.32e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27883866    67 LQSVRILSRDRNCLDPFTSRQSLQALACYAdisvseGSVPESADMDVVLESLKCLCNLVLSSPVAQMLAAEARLVVKLTE 146
Cdd:pfam10165   2 LETLKILGRDPRGADPIFTKEGISTLLKLG------LAFDSAGSSEVSREALRCLANALLLSPEARQIFVDRLLGYADKA 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27883866   147 RVGLYRERSFPHDVQFFDLRLLFLLTALRTDVRQQLFQELKGVRLLTDTLELTLGVTPEGNPPPTL--LPSQETERAMEI 224
Cdd:pfam10165  76 CEKLKLDKSQSSDDEFLDSRILFLLTALRTDIRLQLKKLIEGHSLLAEAIEQILARHAKRYPDSSAssLSPMEDMALTET 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27883866   225 LKVLFNITLDSIKgevDEEDAALYRHLGTLLRHCVMI-ATAGDRTEEFHGHAVNLLGNLPLKcldvlltlephgDSTEFM 303
Cdd:pfam10165 156 LKLLFNLTLFYPD---LVPDSAFSPALPPILRLLLLLpIPSPDPLEPPLSHLINALLNLPLT------------DSKKYE 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27883866   304 GVNMDVIRALLIFLEKRLHKTHRLKESVAPVLSVLTECARMHRPARKFLKAQgwpppqVLPPLRDVRTRPEVGEMLRNKL 383
Cdd:pfam10165 221 GNNMDVVERLLDLLDKRLDAYDELDELLTPLLTLLTRLYEAAREVRKYLRAK------LLPPLKDRKKRLEKGDTLRGRL 294

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27883866   384 VRLMTHLDT-DVKRVAAEFLFVLCSESVPRFIKYTGYGNAAGLLAARGLMAGGRPEGQYSEDEDTDTDEYKEAKASINPV 462
Cdd:pfam10165 295 LRLMTSPLTpRLKDAAAELLFVLCKEDASRFVKYVGYGNAAGFLANRGLLGPGNAGEAYSSSEDSDTEEYKSAKRAINPI 374

                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 27883866   463 TGRVEE-KPPNPMEGMTEEQKEHEAMKLVTMFDKLSRN 499
Cdd:pfam10165 375 TGQVEPpEPENPMEEMTEEEKEREAERLFVLFDRLKRT 412
 
Name Accession Description Interval E-value
Ric8 pfam10165
Guanine nucleotide exchange factor synembryn; Ric8 is involved in the EGL-30 neurotransmitter ...
 67-499 4.32e-137

Guanine nucleotide exchange factor synembryn; Ric8 is involved in the EGL-30 neurotransmitter signalling pathway. It is a guanine nucleotide exchange factor that regulates neurotransmitter secretion.


Pssm-ID: 462973  Cd Length: 412  Bit Score: 403.12  E-value: 4.32e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27883866    67 LQSVRILSRDRNCLDPFTSRQSLQALACYAdisvseGSVPESADMDVVLESLKCLCNLVLSSPVAQMLAAEARLVVKLTE 146
Cdd:pfam10165   2 LETLKILGRDPRGADPIFTKEGISTLLKLG------LAFDSAGSSEVSREALRCLANALLLSPEARQIFVDRLLGYADKA 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27883866   147 RVGLYRERSFPHDVQFFDLRLLFLLTALRTDVRQQLFQELKGVRLLTDTLELTLGVTPEGNPPPTL--LPSQETERAMEI 224
Cdd:pfam10165  76 CEKLKLDKSQSSDDEFLDSRILFLLTALRTDIRLQLKKLIEGHSLLAEAIEQILARHAKRYPDSSAssLSPMEDMALTET 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27883866   225 LKVLFNITLDSIKgevDEEDAALYRHLGTLLRHCVMI-ATAGDRTEEFHGHAVNLLGNLPLKcldvlltlephgDSTEFM 303
Cdd:pfam10165 156 LKLLFNLTLFYPD---LVPDSAFSPALPPILRLLLLLpIPSPDPLEPPLSHLINALLNLPLT------------DSKKYE 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27883866   304 GVNMDVIRALLIFLEKRLHKTHRLKESVAPVLSVLTECARMHRPARKFLKAQgwpppqVLPPLRDVRTRPEVGEMLRNKL 383
Cdd:pfam10165 221 GNNMDVVERLLDLLDKRLDAYDELDELLTPLLTLLTRLYEAAREVRKYLRAK------LLPPLKDRKKRLEKGDTLRGRL 294

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27883866   384 VRLMTHLDT-DVKRVAAEFLFVLCSESVPRFIKYTGYGNAAGLLAARGLMAGGRPEGQYSEDEDTDTDEYKEAKASINPV 462
Cdd:pfam10165 295 LRLMTSPLTpRLKDAAAELLFVLCKEDASRFVKYVGYGNAAGFLANRGLLGPGNAGEAYSSSEDSDTEEYKSAKRAINPI 374

                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 27883866   463 TGRVEE-KPPNPMEGMTEEQKEHEAMKLVTMFDKLSRN 499
Cdd:pfam10165 375 TGQVEPpEPENPMEEMTEEEKEREAERLFVLFDRLKRT 412
 
Name Accession Description Interval E-value
Ric8 pfam10165
Guanine nucleotide exchange factor synembryn; Ric8 is involved in the EGL-30 neurotransmitter ...
 67-499 4.32e-137

Guanine nucleotide exchange factor synembryn; Ric8 is involved in the EGL-30 neurotransmitter signalling pathway. It is a guanine nucleotide exchange factor that regulates neurotransmitter secretion.


Pssm-ID: 462973  Cd Length: 412  Bit Score: 403.12  E-value: 4.32e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27883866    67 LQSVRILSRDRNCLDPFTSRQSLQALACYAdisvseGSVPESADMDVVLESLKCLCNLVLSSPVAQMLAAEARLVVKLTE 146
Cdd:pfam10165   2 LETLKILGRDPRGADPIFTKEGISTLLKLG------LAFDSAGSSEVSREALRCLANALLLSPEARQIFVDRLLGYADKA 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27883866   147 RVGLYRERSFPHDVQFFDLRLLFLLTALRTDVRQQLFQELKGVRLLTDTLELTLGVTPEGNPPPTL--LPSQETERAMEI 224
Cdd:pfam10165  76 CEKLKLDKSQSSDDEFLDSRILFLLTALRTDIRLQLKKLIEGHSLLAEAIEQILARHAKRYPDSSAssLSPMEDMALTET 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27883866   225 LKVLFNITLDSIKgevDEEDAALYRHLGTLLRHCVMI-ATAGDRTEEFHGHAVNLLGNLPLKcldvlltlephgDSTEFM 303
Cdd:pfam10165 156 LKLLFNLTLFYPD---LVPDSAFSPALPPILRLLLLLpIPSPDPLEPPLSHLINALLNLPLT------------DSKKYE 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27883866   304 GVNMDVIRALLIFLEKRLHKTHRLKESVAPVLSVLTECARMHRPARKFLKAQgwpppqVLPPLRDVRTRPEVGEMLRNKL 383
Cdd:pfam10165 221 GNNMDVVERLLDLLDKRLDAYDELDELLTPLLTLLTRLYEAAREVRKYLRAK------LLPPLKDRKKRLEKGDTLRGRL 294

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27883866   384 VRLMTHLDT-DVKRVAAEFLFVLCSESVPRFIKYTGYGNAAGLLAARGLMAGGRPEGQYSEDEDTDTDEYKEAKASINPV 462
Cdd:pfam10165 295 LRLMTSPLTpRLKDAAAELLFVLCKEDASRFVKYVGYGNAAGFLANRGLLGPGNAGEAYSSSEDSDTEEYKSAKRAINPI 374

                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 27883866   463 TGRVEE-KPPNPMEGMTEEQKEHEAMKLVTMFDKLSRN 499
Cdd:pfam10165 375 TGQVEPpEPENPMEEMTEEEKEREAERLFVLFDRLKRT 412
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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