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Conserved domains on  [gi|20336272|ref|NP_071325|]
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sulfate anion transporter 1 isoform a [Homo sapiens]

Protein Classification

solute carrier family 26 protein( domain architecture ID 11489705)

solute carrier family 26 protein similar to eukaryotic sulfate transporters such as Arabidopsis thaliana sulfate transporter 1.1, which is a high-affinity H(+)/sulfate cotransporter that mediates the uptake of the environmental sulfate by plant roots under low-sulfur conditions

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
sulP TIGR00815
high affinity sulphate transporter 1; The SulP family is a large and ubiquitous family with ...
55-683 0e+00

high affinity sulphate transporter 1; The SulP family is a large and ubiquitous family with over 30 sequenced members derived from bacteria, fungi, plants and animals. Many organisms including Bacillus subtilis, Synechocystis sp, Saccharomyces cerevisiae, Arabidopsis thaliana and Caenorhabditis elegans possess multiple SulP family paralogues. Many of these proteins are functionally characterized, and all are sulfate uptake transporters. Some transport their substrate with high affinities, while others transport it with relatively low affinities. Most function by SO42- :H+symport, but SO42- :HCO3- antiport has been reported for the rat protein (spP45380). The bacterial proteins vary in size from 434 residues to 566 residues with one exception, a Mycobacterium tuberculosis protein with 784 residues. The eukaryotic proteins vary in size from 611 residues to 893 residues with one exception, a protein designated "early nodulin 70 protein" from Glycine max which is reported to be of 485 residues. Thus, the eukaryotic proteins are almost without exception larger than the prokaryotic proteins. These proteins exhibit 10-13 putative transmembrane a-helical spanners (TMSs) depending on the protein. The phylogenetic tree for the SulP family reveals five principal branches. Three of these are bacterial specific as follows: one bears a single protein from M. tuberculosis; a second bears two proteins, one from M. tuberculosis, the other from Synechocystis sp, and the third bears all remaining prokaryotic proteins. The remaining two clusters bear only eukaryotic proteins with the animal proteins all localized to one branch and the plant and fungal proteins localized to the other. The generalized transport reactions catalyzed by SulP family proteins are: (1) SO42- (out) + nH+ (out) --> SO42- (in) + nH+ (in). (2) SO42- (out) + nHCO3- (in) SO42- (in) + nHCO3- (out). [Transport and binding proteins, Anions]


:

Pssm-ID: 273284 [Multi-domain]  Cd Length: 552  Bit Score: 555.79  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336272    55 PATRWLRQYRPREyLAGDVMSGLVIGIILVPQAIAYSLLAGLQPIYSLYTSFFANLIYFLMGTSRHVSVGIFSLLCLMVG 134
Cdd:TIGR00815   1 PVLRWLRKYRLKK-FKGDLMAGLTVGILLIPQAIAYAKLAGLPPIYGLYTSFVPPIIYALFGSSRHIAIGPTASVSLLLG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336272   135 QVVDRELQLAGFDpsqdglqpgansstlngsaamldcgrdcYAIRVATALTLMTGLYQVLMGVLRLGFVSAYLSQPLLDG 214
Cdd:TIGR00815  80 SLVQREGLQGLFD----------------------------DYIRLAFTATLLAGIFQVIMGLLRLGFLIEYLSHAVLVG 131
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336272   215 FAMGASVTILTSQLKHLLGVRI-PRHQGPGMVVLTWLSLLRGagqaNVCDVVTSTVCLAVLLAAKELSDRYRHRLRVPLP 293
Cdd:TIGR00815 132 FTAGAAITIGLSQLKGLLGLSIfVKTDILGVVISTWASLHQN----NWCTLVIGLLFLLFLLATKELGKRNKKLLWAPAP 207
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336272   294 TELLVIVVATLVSHFGQLHKRfGSSVAGDIPTG--FMPPQVPEPRLMQRVALDAVALALVAAAFSISLAEMFARSHGYSV 371
Cdd:TIGR00815 208 APLLVVVLATLIVTIGLHDSQ-GVSIVGHIPQGlsFFPPITFTWQHLPTLAPDAIAIAIVGLTESILTARVFAAMTGYEI 286
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336272   372 RANQELLAVGCCNVLPAFLHCFATSAALAKSLVKTATGCRTQLSSVVSATVVLLVLLALAPLFHDLQRSVLACVIVVSLR 451
Cdd:TIGR00815 287 DANKELVALGIANIVGSFFSCYPATGSLSRTAVNYKAGCKTQLSAIVMAIVVLLVLLVLAPLFYYIPLAALAAIIISAAV 366
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336272   452 GaLRKVWDLPRLWRMSPADALVWAGTAATCMLVSTEAGLLAGVILSLLSLAGRTQRPRTALLARIGDTAFYEDATEFEGL 531
Cdd:TIGR00815 367 G-LIDIRELYLLWKADKMDFVVWLGTFLGVVFTSIEIGLLVGVSLSAFFFILRVARPRAAVLGRIPGTEDYENIEQYPKA 445
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336272   532 VPEPGVRVFRFGGPLYYANKDFFLQSLYSltgldagcmaarrkeggsetgvgeggpaqgedlgpvstraALVPAAAGFHT 611
Cdd:TIGR00815 446 QTPPGILIFRVDGPLYFANAEDLKERLLK----------------------------------------WLETLELDPQI 485
                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 20336272   612 VVIDCAPLLFLDAAGVSTLQDLRRDYGALGISLLLACCSPPVRDILSRGGFLGEgpgdtAEEEQLFLSVHDA 683
Cdd:TIGR00815 486 IILDMSAVPFLDTSGIHALEELFKELKARGIQLLLANPNPAVISTLARAGFVEL-----IGEEHFFPSVHDA 552
 
Name Accession Description Interval E-value
sulP TIGR00815
high affinity sulphate transporter 1; The SulP family is a large and ubiquitous family with ...
55-683 0e+00

high affinity sulphate transporter 1; The SulP family is a large and ubiquitous family with over 30 sequenced members derived from bacteria, fungi, plants and animals. Many organisms including Bacillus subtilis, Synechocystis sp, Saccharomyces cerevisiae, Arabidopsis thaliana and Caenorhabditis elegans possess multiple SulP family paralogues. Many of these proteins are functionally characterized, and all are sulfate uptake transporters. Some transport their substrate with high affinities, while others transport it with relatively low affinities. Most function by SO42- :H+symport, but SO42- :HCO3- antiport has been reported for the rat protein (spP45380). The bacterial proteins vary in size from 434 residues to 566 residues with one exception, a Mycobacterium tuberculosis protein with 784 residues. The eukaryotic proteins vary in size from 611 residues to 893 residues with one exception, a protein designated "early nodulin 70 protein" from Glycine max which is reported to be of 485 residues. Thus, the eukaryotic proteins are almost without exception larger than the prokaryotic proteins. These proteins exhibit 10-13 putative transmembrane a-helical spanners (TMSs) depending on the protein. The phylogenetic tree for the SulP family reveals five principal branches. Three of these are bacterial specific as follows: one bears a single protein from M. tuberculosis; a second bears two proteins, one from M. tuberculosis, the other from Synechocystis sp, and the third bears all remaining prokaryotic proteins. The remaining two clusters bear only eukaryotic proteins with the animal proteins all localized to one branch and the plant and fungal proteins localized to the other. The generalized transport reactions catalyzed by SulP family proteins are: (1) SO42- (out) + nH+ (out) --> SO42- (in) + nH+ (in). (2) SO42- (out) + nHCO3- (in) SO42- (in) + nHCO3- (out). [Transport and binding proteins, Anions]


Pssm-ID: 273284 [Multi-domain]  Cd Length: 552  Bit Score: 555.79  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336272    55 PATRWLRQYRPREyLAGDVMSGLVIGIILVPQAIAYSLLAGLQPIYSLYTSFFANLIYFLMGTSRHVSVGIFSLLCLMVG 134
Cdd:TIGR00815   1 PVLRWLRKYRLKK-FKGDLMAGLTVGILLIPQAIAYAKLAGLPPIYGLYTSFVPPIIYALFGSSRHIAIGPTASVSLLLG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336272   135 QVVDRELQLAGFDpsqdglqpgansstlngsaamldcgrdcYAIRVATALTLMTGLYQVLMGVLRLGFVSAYLSQPLLDG 214
Cdd:TIGR00815  80 SLVQREGLQGLFD----------------------------DYIRLAFTATLLAGIFQVIMGLLRLGFLIEYLSHAVLVG 131
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336272   215 FAMGASVTILTSQLKHLLGVRI-PRHQGPGMVVLTWLSLLRGagqaNVCDVVTSTVCLAVLLAAKELSDRYRHRLRVPLP 293
Cdd:TIGR00815 132 FTAGAAITIGLSQLKGLLGLSIfVKTDILGVVISTWASLHQN----NWCTLVIGLLFLLFLLATKELGKRNKKLLWAPAP 207
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336272   294 TELLVIVVATLVSHFGQLHKRfGSSVAGDIPTG--FMPPQVPEPRLMQRVALDAVALALVAAAFSISLAEMFARSHGYSV 371
Cdd:TIGR00815 208 APLLVVVLATLIVTIGLHDSQ-GVSIVGHIPQGlsFFPPITFTWQHLPTLAPDAIAIAIVGLTESILTARVFAAMTGYEI 286
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336272   372 RANQELLAVGCCNVLPAFLHCFATSAALAKSLVKTATGCRTQLSSVVSATVVLLVLLALAPLFHDLQRSVLACVIVVSLR 451
Cdd:TIGR00815 287 DANKELVALGIANIVGSFFSCYPATGSLSRTAVNYKAGCKTQLSAIVMAIVVLLVLLVLAPLFYYIPLAALAAIIISAAV 366
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336272   452 GaLRKVWDLPRLWRMSPADALVWAGTAATCMLVSTEAGLLAGVILSLLSLAGRTQRPRTALLARIGDTAFYEDATEFEGL 531
Cdd:TIGR00815 367 G-LIDIRELYLLWKADKMDFVVWLGTFLGVVFTSIEIGLLVGVSLSAFFFILRVARPRAAVLGRIPGTEDYENIEQYPKA 445
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336272   532 VPEPGVRVFRFGGPLYYANKDFFLQSLYSltgldagcmaarrkeggsetgvgeggpaqgedlgpvstraALVPAAAGFHT 611
Cdd:TIGR00815 446 QTPPGILIFRVDGPLYFANAEDLKERLLK----------------------------------------WLETLELDPQI 485
                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 20336272   612 VVIDCAPLLFLDAAGVSTLQDLRRDYGALGISLLLACCSPPVRDILSRGGFLGEgpgdtAEEEQLFLSVHDA 683
Cdd:TIGR00815 486 IILDMSAVPFLDTSGIHALEELFKELKARGIQLLLANPNPAVISTLARAGFVEL-----IGEEHFFPSVHDA 552
Sulfate_transp pfam00916
Sulfate permease family; This family of integral membrane proteins are known as the Sulfate ...
69-477 1.51e-122

Sulfate permease family; This family of integral membrane proteins are known as the Sulfate Permease (SulP) family. SulP is a large family found in all domains of life. Although sulfate is a commonly transported ion there are many other activities in this family. See the TCDB description for a comprehensive summary.


Pssm-ID: 459995 [Multi-domain]  Cd Length: 379  Bit Score: 370.04  E-value: 1.51e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336272    69 LAGDVMSGLVIGIILVPQAIAYSLLAGLQPIYSLYTSFFANLIYFLMGTSRHVSVGIFSLLCLMVGQVVDRELQlagfdp 148
Cdd:pfam00916   1 LKGDLIAGITVAILAIPQALAYAILAGLPPIYGLYSSFVPGFVYALFGTSRHLAIGPVAVLSLMVGAAIAKLAA------ 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336272   149 sqdglqpgansstlngsaamldcGRDCYAIRVATALTLMTGLYQVLMGVLRLGFVSAYLSQPLLDGFAMGASVTILTSQL 228
Cdd:pfam00916  75 -----------------------KDPELGIALAFTLTFLAGIIQLALGLLRLGFLVTFLSHAVISGFMGGAAIVILLSQL 131
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336272   229 KHLLGVRIprHQGPGMVVLTWLSLLRGAGQANVCDVVTSTVCLAVLLAAKELSDRYRHRLRVPLPTELLVIVVATLVSHF 308
Cdd:pfam00916 132 KVLLGLTN--FSGPGYVVSVLQSLFTNLDKVNLATLVLGLLVLVILLFTKELGKKYKKLFWIPAPAPLVAVVLATLVSAI 209
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336272   309 GQLHKRFGSSVAGDIPTGFMPPQVPEPR--LMQRVALDAVALALVAAAFSISLAEMFARSHGYSVRANQELLAVGCCNVL 386
Cdd:pfam00916 210 FDLLRRYGVKIVGEIPSGLPPFSLPKFSwsLLSALLPDALAIAIVGLLEAIAISKSFAKKKGYEVDSNQELVALGFANIL 289
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336272   387 PAFLHCFATSAALAKSLVKTATGCRTQLSSVVSATVVLLVLLALAPLFHDLQRSVLACVIVVSLRGaLRKVWDLPRLWRM 466
Cdd:pfam00916 290 SGLFGGYPATGAFSRSAVNIKAGAKTPLSGIIMAVIVLLVLLFLTPLFAYIPKAVLAAIIIVAGKG-LIDYRELKHLWRL 368
                         410
                  ....*....|.
gi 20336272   467 SPADALVWAGT 477
Cdd:pfam00916 369 SKLDFLIWLAT 379
SUL1 COG0659
Sulfate permease or related transporter, MFS superfamily [Inorganic ion transport and ...
66-692 5.82e-82

Sulfate permease or related transporter, MFS superfamily [Inorganic ion transport and metabolism];


Pssm-ID: 440424 [Multi-domain]  Cd Length: 529  Bit Score: 269.67  E-value: 5.82e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336272  66 REYLAGDVMSGLVIGIILVPQAIAYSLLAGLQPIYSLYTSFFANLIYFLMGTSRHVSVGIFSLLCLMVGQVVdrelqlag 145
Cdd:COG0659   4 RSNLRGDLLAGLTVALVALPLALAFAIAAGLPPEAGLYAAIVGGIVYALFGGSRLLISGPTAALAVVVAAAV-------- 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336272 146 fdpsqdglqpgansSTLnGSAAMLdcgrdcyairvaTALTLMTGLYQVLMGVLRLGFVSAYLSQPLLDGFAMGASVTILT 225
Cdd:COG0659  76 --------------APL-GSLALL------------LAATLLAGVLQLLLGLLRLGRLARFIPRPVIVGFLAGIAILIIL 128
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336272 226 SQLKHLLGVRIPRHQGPGmvvlTWLSLLRGAGQANVCDVVTSTVCLAVLLAAKelsdryRHRLRVPLPteLLVIVVATLV 305
Cdd:COG0659 129 GQLPHLLGLPAPGGSFLE----KLAALLAALGEINPPTLALGLLTLAILLLLP------RLLKRIPGP--LVAVVLGTLL 196
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336272 306 SHFGQLHKRfgssVAGDIPTGFMPPQVPEPRLMQrvaldavALALVAAAFSISL---------AEMFARSHGYSVRANQE 376
Cdd:COG0659 197 VWLLGLDVA----TVGEIPSGLPSFSLPDFSLET-------LRALLPPALTIALvgsieslltARAVDAMTGTRSDPNRE 265
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336272 377 LLAVGCCNVLPAFLHCFATSAALAKSLVKTATGCRTQLSSVVSATVVLLVLLALAPLFHDLQRSVLACV-IVVSLRgaLR 455
Cdd:COG0659 266 LIAQGLANIASGLFGGLPVTGSISRSAVNVKAGARTRLSGIVHALFLLLVLLFLAPLLAYIPLAALAAIlIVVGIG--LI 343
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336272 456 KVWDLPRLWRMSPADALVWAGTAATCMLVSTEAGLLAGVILSLLSLAGRTQRPRTALLaRIGDTAFYeDATEFEGLVPEP 535
Cdd:COG0659 344 DWRSFRRLWRAPRSDFLVMLVTFLVTVFTDLLIGVLVGVLLSLLLFLRRVSRPHVVVL-RVPGTHFR-NVERHPEAETGP 421
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336272 536 GVRVFRFGGPLYYANKDFFLQSLYSLtgldagcmaarrkeggsetgvgeggpaqgedlgpvstraalvpaAAGFHTVVID 615
Cdd:COG0659 422 GVLVYRLDGPLFFGNAERLKERLDAL--------------------------------------------APDPRVVILD 457
                       570       580       590       600       610       620       630
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 20336272 616 CAPLLFLDAAGVSTLQDLRRDYGALGISLLLACCSPPVRDILSRGGFLgegpgDTAEEEQLFLSVHDAVQTARARHR 692
Cdd:COG0659 458 LSAVPFIDATALEALEELAERLRARGITLELAGLKPPVRDLLERAGLL-----DELGEERVFPDLDEALEAAEERAE 529
STAS_SulP_like_sulfate_transporter cd07042
Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, ...
528-669 6.09e-18

Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; The SulP family is a large and diverse family of anion transporters, with members from eubacteria, plants, fungi, and mammals. They contain 10 to 14 transmembrane helices which form the catalytic core of the protein and a C-terminal extension, the STAS (Sulphate Transporter and AntiSigma factor antagonist) domain which plays a role in the function and regulation of the transport activity. The STAS domain is found in the C-terminal region of sulphate transporters and bacterial anti-sigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.


Pssm-ID: 132913 [Multi-domain]  Cd Length: 107  Bit Score: 79.59  E-value: 6.09e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336272 528 FEGLVPEPGVRVFRFGGPLYYANKDFFLQSLYSLTGldagcmaarrkeggsetgvgeggpaqgedlgpvstraalvpAAA 607
Cdd:cd07042   1 YPLAEEPPGVLIYRIDGPLFFGNAEYFKDRLLRLVD-----------------------------------------EDP 39
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 20336272 608 GFHTVVIDCAPLLFLDAAGVSTLQDLRRDYGALGISLLLACCSPPVRDILSRGGFLGEGPGD 669
Cdd:cd07042  40 PLKVVILDLSAVNFIDSTAAEALEELVKDLRKRGVELYLAGLNPQVRELLERAGLLDEIGEE 101
PRK11660 PRK11660
putative transporter; Provisional
69-320 1.85e-14

putative transporter; Provisional


Pssm-ID: 183265 [Multi-domain]  Cd Length: 568  Bit Score: 76.91  E-value: 1.85e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336272   69 LAGDVMSGLVIGIILVPQAIAYSLLAGLQPIYSLYTSFFANLIYFLMGTSRhVSV----GIFSLLCLMVGQvvdrelqla 144
Cdd:PRK11660  29 FTRDLIAGITVGIIAIPLAMALAIASGVPPQYGLYTAAVAGIVIALTGGSR-FSVsgptAAFVVILYPVSQ--------- 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336272  145 gfdpsQDGLqpgansstlngsAAMLDCgrdcyairvatalTLMTGLYQVLMGVLRLGFVSAYLSQPLLDGFAMGASVTIL 224
Cdd:PRK11660  99 -----QFGL------------AGLLVA-------------TLMSGIILILMGLARLGRLIEYIPLSVTLGFTSGIGIVIA 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336272  225 TSQLKHLLGVRIPrhQGPGMVVLTWLSLLRGAGQANVCDVVTSTVCLAVLLaakelsdrYRHRLRVPLPTELLVIVVATL 304
Cdd:PRK11660 149 TLQIKDFFGLQMA--HVPEHYLEKVGALFQALPTINWGDALIGIVTLGVLI--------LWPRLKIRLPGHLPALLAGTA 218
                        250
                 ....*....|....*.
gi 20336272  305 VShfGQLHkRFGSSVA 320
Cdd:PRK11660 219 VM--GVLN-LLGGHVA 231
 
Name Accession Description Interval E-value
sulP TIGR00815
high affinity sulphate transporter 1; The SulP family is a large and ubiquitous family with ...
55-683 0e+00

high affinity sulphate transporter 1; The SulP family is a large and ubiquitous family with over 30 sequenced members derived from bacteria, fungi, plants and animals. Many organisms including Bacillus subtilis, Synechocystis sp, Saccharomyces cerevisiae, Arabidopsis thaliana and Caenorhabditis elegans possess multiple SulP family paralogues. Many of these proteins are functionally characterized, and all are sulfate uptake transporters. Some transport their substrate with high affinities, while others transport it with relatively low affinities. Most function by SO42- :H+symport, but SO42- :HCO3- antiport has been reported for the rat protein (spP45380). The bacterial proteins vary in size from 434 residues to 566 residues with one exception, a Mycobacterium tuberculosis protein with 784 residues. The eukaryotic proteins vary in size from 611 residues to 893 residues with one exception, a protein designated "early nodulin 70 protein" from Glycine max which is reported to be of 485 residues. Thus, the eukaryotic proteins are almost without exception larger than the prokaryotic proteins. These proteins exhibit 10-13 putative transmembrane a-helical spanners (TMSs) depending on the protein. The phylogenetic tree for the SulP family reveals five principal branches. Three of these are bacterial specific as follows: one bears a single protein from M. tuberculosis; a second bears two proteins, one from M. tuberculosis, the other from Synechocystis sp, and the third bears all remaining prokaryotic proteins. The remaining two clusters bear only eukaryotic proteins with the animal proteins all localized to one branch and the plant and fungal proteins localized to the other. The generalized transport reactions catalyzed by SulP family proteins are: (1) SO42- (out) + nH+ (out) --> SO42- (in) + nH+ (in). (2) SO42- (out) + nHCO3- (in) SO42- (in) + nHCO3- (out). [Transport and binding proteins, Anions]


Pssm-ID: 273284 [Multi-domain]  Cd Length: 552  Bit Score: 555.79  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336272    55 PATRWLRQYRPREyLAGDVMSGLVIGIILVPQAIAYSLLAGLQPIYSLYTSFFANLIYFLMGTSRHVSVGIFSLLCLMVG 134
Cdd:TIGR00815   1 PVLRWLRKYRLKK-FKGDLMAGLTVGILLIPQAIAYAKLAGLPPIYGLYTSFVPPIIYALFGSSRHIAIGPTASVSLLLG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336272   135 QVVDRELQLAGFDpsqdglqpgansstlngsaamldcgrdcYAIRVATALTLMTGLYQVLMGVLRLGFVSAYLSQPLLDG 214
Cdd:TIGR00815  80 SLVQREGLQGLFD----------------------------DYIRLAFTATLLAGIFQVIMGLLRLGFLIEYLSHAVLVG 131
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336272   215 FAMGASVTILTSQLKHLLGVRI-PRHQGPGMVVLTWLSLLRGagqaNVCDVVTSTVCLAVLLAAKELSDRYRHRLRVPLP 293
Cdd:TIGR00815 132 FTAGAAITIGLSQLKGLLGLSIfVKTDILGVVISTWASLHQN----NWCTLVIGLLFLLFLLATKELGKRNKKLLWAPAP 207
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336272   294 TELLVIVVATLVSHFGQLHKRfGSSVAGDIPTG--FMPPQVPEPRLMQRVALDAVALALVAAAFSISLAEMFARSHGYSV 371
Cdd:TIGR00815 208 APLLVVVLATLIVTIGLHDSQ-GVSIVGHIPQGlsFFPPITFTWQHLPTLAPDAIAIAIVGLTESILTARVFAAMTGYEI 286
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336272   372 RANQELLAVGCCNVLPAFLHCFATSAALAKSLVKTATGCRTQLSSVVSATVVLLVLLALAPLFHDLQRSVLACVIVVSLR 451
Cdd:TIGR00815 287 DANKELVALGIANIVGSFFSCYPATGSLSRTAVNYKAGCKTQLSAIVMAIVVLLVLLVLAPLFYYIPLAALAAIIISAAV 366
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336272   452 GaLRKVWDLPRLWRMSPADALVWAGTAATCMLVSTEAGLLAGVILSLLSLAGRTQRPRTALLARIGDTAFYEDATEFEGL 531
Cdd:TIGR00815 367 G-LIDIRELYLLWKADKMDFVVWLGTFLGVVFTSIEIGLLVGVSLSAFFFILRVARPRAAVLGRIPGTEDYENIEQYPKA 445
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336272   532 VPEPGVRVFRFGGPLYYANKDFFLQSLYSltgldagcmaarrkeggsetgvgeggpaqgedlgpvstraALVPAAAGFHT 611
Cdd:TIGR00815 446 QTPPGILIFRVDGPLYFANAEDLKERLLK----------------------------------------WLETLELDPQI 485
                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 20336272   612 VVIDCAPLLFLDAAGVSTLQDLRRDYGALGISLLLACCSPPVRDILSRGGFLGEgpgdtAEEEQLFLSVHDA 683
Cdd:TIGR00815 486 IILDMSAVPFLDTSGIHALEELFKELKARGIQLLLANPNPAVISTLARAGFVEL-----IGEEHFFPSVHDA 552
Sulfate_transp pfam00916
Sulfate permease family; This family of integral membrane proteins are known as the Sulfate ...
69-477 1.51e-122

Sulfate permease family; This family of integral membrane proteins are known as the Sulfate Permease (SulP) family. SulP is a large family found in all domains of life. Although sulfate is a commonly transported ion there are many other activities in this family. See the TCDB description for a comprehensive summary.


Pssm-ID: 459995 [Multi-domain]  Cd Length: 379  Bit Score: 370.04  E-value: 1.51e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336272    69 LAGDVMSGLVIGIILVPQAIAYSLLAGLQPIYSLYTSFFANLIYFLMGTSRHVSVGIFSLLCLMVGQVVDRELQlagfdp 148
Cdd:pfam00916   1 LKGDLIAGITVAILAIPQALAYAILAGLPPIYGLYSSFVPGFVYALFGTSRHLAIGPVAVLSLMVGAAIAKLAA------ 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336272   149 sqdglqpgansstlngsaamldcGRDCYAIRVATALTLMTGLYQVLMGVLRLGFVSAYLSQPLLDGFAMGASVTILTSQL 228
Cdd:pfam00916  75 -----------------------KDPELGIALAFTLTFLAGIIQLALGLLRLGFLVTFLSHAVISGFMGGAAIVILLSQL 131
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336272   229 KHLLGVRIprHQGPGMVVLTWLSLLRGAGQANVCDVVTSTVCLAVLLAAKELSDRYRHRLRVPLPTELLVIVVATLVSHF 308
Cdd:pfam00916 132 KVLLGLTN--FSGPGYVVSVLQSLFTNLDKVNLATLVLGLLVLVILLFTKELGKKYKKLFWIPAPAPLVAVVLATLVSAI 209
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336272   309 GQLHKRFGSSVAGDIPTGFMPPQVPEPR--LMQRVALDAVALALVAAAFSISLAEMFARSHGYSVRANQELLAVGCCNVL 386
Cdd:pfam00916 210 FDLLRRYGVKIVGEIPSGLPPFSLPKFSwsLLSALLPDALAIAIVGLLEAIAISKSFAKKKGYEVDSNQELVALGFANIL 289
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336272   387 PAFLHCFATSAALAKSLVKTATGCRTQLSSVVSATVVLLVLLALAPLFHDLQRSVLACVIVVSLRGaLRKVWDLPRLWRM 466
Cdd:pfam00916 290 SGLFGGYPATGAFSRSAVNIKAGAKTPLSGIIMAVIVLLVLLFLTPLFAYIPKAVLAAIIIVAGKG-LIDYRELKHLWRL 368
                         410
                  ....*....|.
gi 20336272   467 SPADALVWAGT 477
Cdd:pfam00916 369 SKLDFLIWLAT 379
SUL1 COG0659
Sulfate permease or related transporter, MFS superfamily [Inorganic ion transport and ...
66-692 5.82e-82

Sulfate permease or related transporter, MFS superfamily [Inorganic ion transport and metabolism];


Pssm-ID: 440424 [Multi-domain]  Cd Length: 529  Bit Score: 269.67  E-value: 5.82e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336272  66 REYLAGDVMSGLVIGIILVPQAIAYSLLAGLQPIYSLYTSFFANLIYFLMGTSRHVSVGIFSLLCLMVGQVVdrelqlag 145
Cdd:COG0659   4 RSNLRGDLLAGLTVALVALPLALAFAIAAGLPPEAGLYAAIVGGIVYALFGGSRLLISGPTAALAVVVAAAV-------- 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336272 146 fdpsqdglqpgansSTLnGSAAMLdcgrdcyairvaTALTLMTGLYQVLMGVLRLGFVSAYLSQPLLDGFAMGASVTILT 225
Cdd:COG0659  76 --------------APL-GSLALL------------LAATLLAGVLQLLLGLLRLGRLARFIPRPVIVGFLAGIAILIIL 128
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336272 226 SQLKHLLGVRIPRHQGPGmvvlTWLSLLRGAGQANVCDVVTSTVCLAVLLAAKelsdryRHRLRVPLPteLLVIVVATLV 305
Cdd:COG0659 129 GQLPHLLGLPAPGGSFLE----KLAALLAALGEINPPTLALGLLTLAILLLLP------RLLKRIPGP--LVAVVLGTLL 196
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336272 306 SHFGQLHKRfgssVAGDIPTGFMPPQVPEPRLMQrvaldavALALVAAAFSISL---------AEMFARSHGYSVRANQE 376
Cdd:COG0659 197 VWLLGLDVA----TVGEIPSGLPSFSLPDFSLET-------LRALLPPALTIALvgsieslltARAVDAMTGTRSDPNRE 265
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336272 377 LLAVGCCNVLPAFLHCFATSAALAKSLVKTATGCRTQLSSVVSATVVLLVLLALAPLFHDLQRSVLACV-IVVSLRgaLR 455
Cdd:COG0659 266 LIAQGLANIASGLFGGLPVTGSISRSAVNVKAGARTRLSGIVHALFLLLVLLFLAPLLAYIPLAALAAIlIVVGIG--LI 343
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336272 456 KVWDLPRLWRMSPADALVWAGTAATCMLVSTEAGLLAGVILSLLSLAGRTQRPRTALLaRIGDTAFYeDATEFEGLVPEP 535
Cdd:COG0659 344 DWRSFRRLWRAPRSDFLVMLVTFLVTVFTDLLIGVLVGVLLSLLLFLRRVSRPHVVVL-RVPGTHFR-NVERHPEAETGP 421
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336272 536 GVRVFRFGGPLYYANKDFFLQSLYSLtgldagcmaarrkeggsetgvgeggpaqgedlgpvstraalvpaAAGFHTVVID 615
Cdd:COG0659 422 GVLVYRLDGPLFFGNAERLKERLDAL--------------------------------------------APDPRVVILD 457
                       570       580       590       600       610       620       630
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 20336272 616 CAPLLFLDAAGVSTLQDLRRDYGALGISLLLACCSPPVRDILSRGGFLgegpgDTAEEEQLFLSVHDAVQTARARHR 692
Cdd:COG0659 458 LSAVPFIDATALEALEELAERLRARGITLELAGLKPPVRDLLERAGLL-----DELGEERVFPDLDEALEAAEERAE 529
STAS_SulP_like_sulfate_transporter cd07042
Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, ...
528-669 6.09e-18

Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; The SulP family is a large and diverse family of anion transporters, with members from eubacteria, plants, fungi, and mammals. They contain 10 to 14 transmembrane helices which form the catalytic core of the protein and a C-terminal extension, the STAS (Sulphate Transporter and AntiSigma factor antagonist) domain which plays a role in the function and regulation of the transport activity. The STAS domain is found in the C-terminal region of sulphate transporters and bacterial anti-sigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.


Pssm-ID: 132913 [Multi-domain]  Cd Length: 107  Bit Score: 79.59  E-value: 6.09e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336272 528 FEGLVPEPGVRVFRFGGPLYYANKDFFLQSLYSLTGldagcmaarrkeggsetgvgeggpaqgedlgpvstraalvpAAA 607
Cdd:cd07042   1 YPLAEEPPGVLIYRIDGPLFFGNAEYFKDRLLRLVD-----------------------------------------EDP 39
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 20336272 608 GFHTVVIDCAPLLFLDAAGVSTLQDLRRDYGALGISLLLACCSPPVRDILSRGGFLGEGPGD 669
Cdd:cd07042  40 PLKVVILDLSAVNFIDSTAAEALEELVKDLRKRGVELYLAGLNPQVRELLERAGLLDEIGEE 101
STAS pfam01740
STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is ...
535-683 3.13e-15

STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is found in the C terminal region of Sulphate transporters and bacterial antisigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.


Pssm-ID: 426404 [Multi-domain]  Cd Length: 106  Bit Score: 71.88  E-value: 3.13e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336272   535 PGVRVFRFGGPLYYANKDFFLQSLYSLTgldagcmaarrkeggsetgvgeggpaqgedlgpvstraalvpAAAGFHTVVI 614
Cdd:pfam01740   8 PGILILRLDGPLDFANAESLRERLLRAL------------------------------------------EEGEIKHVVL 45
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20336272   615 DCAPLLFLDAAGVSTLQDLRRDYGALGISLLLACCSPPVRDILSRGGFLgegpgdtaEEEQLFLSVHDA 683
Cdd:pfam01740  46 DLSAVPFIDSSGLGALEELYKELRRRGVELVLVGPSPEVARTLEKTGLD--------DIIKIFPTVAEA 106
PRK11660 PRK11660
putative transporter; Provisional
69-320 1.85e-14

putative transporter; Provisional


Pssm-ID: 183265 [Multi-domain]  Cd Length: 568  Bit Score: 76.91  E-value: 1.85e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336272   69 LAGDVMSGLVIGIILVPQAIAYSLLAGLQPIYSLYTSFFANLIYFLMGTSRhVSV----GIFSLLCLMVGQvvdrelqla 144
Cdd:PRK11660  29 FTRDLIAGITVGIIAIPLAMALAIASGVPPQYGLYTAAVAGIVIALTGGSR-FSVsgptAAFVVILYPVSQ--------- 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336272  145 gfdpsQDGLqpgansstlngsAAMLDCgrdcyairvatalTLMTGLYQVLMGVLRLGFVSAYLSQPLLDGFAMGASVTIL 224
Cdd:PRK11660  99 -----QFGL------------AGLLVA-------------TLMSGIILILMGLARLGRLIEYIPLSVTLGFTSGIGIVIA 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336272  225 TSQLKHLLGVRIPrhQGPGMVVLTWLSLLRGAGQANVCDVVTSTVCLAVLLaakelsdrYRHRLRVPLPTELLVIVVATL 304
Cdd:PRK11660 149 TLQIKDFFGLQMA--HVPEHYLEKVGALFQALPTINWGDALIGIVTLGVLI--------LWPRLKIRLPGHLPALLAGTA 218
                        250
                 ....*....|....*.
gi 20336272  305 VShfGQLHkRFGSSVA 320
Cdd:PRK11660 219 VM--GVLN-LLGGHVA 231
STAS cd06844
Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of ...
535-662 4.27e-11

Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; The STAS (Sulphate Transporter and Anti-Sigma factor antagonist) domain is found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors, like anti-anti-sigma factors and "stressosome" components. The sigma factor regulators are involved in protein-protein interaction which is regulated by phosphorylation.


Pssm-ID: 132911 [Multi-domain]  Cd Length: 100  Bit Score: 59.80  E-value: 4.27e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336272 535 PGVRVFRFGGPLYYANKDFFLQSLYSLTGLDAGcmaarrkeggsetgvgeggpaqgedlgpvstraalvpaaagfHTVVI 614
Cdd:cd06844   7 DDYWVVRLEGELDHHSVEQFKEELLHNITNVAG------------------------------------------KTIVI 44
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 20336272 615 DCAPLLFLDAAGVSTLQDLRRDYGALGISLLLACCSPPVRDILSRGGF 662
Cdd:cd06844  45 DISALEFMDSSGTGVLLERSRLAEAVGGQFVLTGISPAVRITLTESGL 92
STAS_anti-anti-sigma_factors cd07043
Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key ...
599-662 5.13e-05

Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.


Pssm-ID: 132914 [Multi-domain]  Cd Length: 99  Bit Score: 42.51  E-value: 5.13e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 20336272 599 RAALVPA-AAGFHTVVIDCAPLLFLDAAGVSTLQDLRRDYGALGISLLLACCSPPVRDILSRGGF 662
Cdd:cd07043  27 REALEELlAEGPRRLVLDLSGVTFIDSSGLGVLLGAYKRARAAGGRLVLVNVSPAVRRVLELTGL 91
SpoIIAA COG1366
Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction ...
599-662 6.60e-05

Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction mechanisms];


Pssm-ID: 440977 [Multi-domain]  Cd Length: 93  Bit Score: 42.15  E-value: 6.60e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 20336272 599 RAALVPA-AAGFHTVVIDCAPLLFLDAAGVSTLQDLRRDYGALGISLLLACCSPPVRDILSRGGF 662
Cdd:COG1366  28 REALLEAlETGARRVVLDLSGVTFIDSSGLGALLSLAKAARLLGGRLVLVGVSPAVARVLELTGL 92
STAS_2 pfam13466
STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is ...
599-662 5.90e-03

STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is found in the C-terminal region of Sulphate transporters and bacterial antisigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.


Pssm-ID: 433231 [Multi-domain]  Cd Length: 80  Bit Score: 36.05  E-value: 5.90e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 20336272   599 RAALVPAAAGFHTVVIDCAPLLFLDAAGVSTLQDLRRDYGALGISLLLACCSPPVRDILSRGGF 662
Cdd:pfam13466  16 REALLAALAAGSPVVVDLSGVERVDSAGLALLLALARRARARGKRLVLRGLPPALLRLLRLLGL 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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