Calcium-binding EGF-like domain;

                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 42476320     73 DKNECQFGAtlVCGNHTSCHNTPGGFYCICLEGYRATNN 111
Cdd:smart00179   1 DIDECASGN--PCQNGGTCVNTVGSYRCECPPGYTDGRN 37

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 42476320 239 CGNPPEMRHAILVGNHSS-RLGGVARYVCQEGFEsPGGKITSVCTEKGTWRESTLTC 294
Cdd:cd00033   1 CPPPPVPENGTVTGSKGSySYGSTVTYSCNEGYT-LVGSSTITCTENGGWSPPPPTC 56

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                        10        20        30
                ....*....|....*....|....*....|....*.
gi 42476320 125 DIDECEVSGLCRHGGRCVNTHGSFECYCMDGYLPRN 160
Cdd:cd00054   1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 42476320 179 CGTPPEVPDGYIIGNYTS-SLGSQVRYACREGFFSVPEDTVsSCTGLGTWESPKLHCQ 235
Cdd:cd00033   1 CPPPPVPENGTVTGSKGSySYGSTVTYSCNEGYTLVGSSTI-TCTENGGWSPPPPTCE 57

Sushi repeat (SCR repeat);

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 42476320   179 CGTPPEVPDGYIIGNYTS-SLGSQVRYACREGFFSVPEDTVsSCTGLGTWESPKLHC 234
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEyNYGASVSYECDPGYRLVGSPTI-TCQEDGTWSPPFPEC 56

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 42476320 239 CGNPPEMRHAILVGNHSS-RLGGVARYVCQEGFEsPGGKITSVCTEKGTWRESTLTC 294
Cdd:cd00033   1 CPPPPVPENGTVTGSKGSySYGSTVTYSCNEGYT-LVGSSTITCTENGGWSPPPPTC 56

Calcium-binding EGF domain;

                          10        20        30
                  ....*....|....*....|....*....|..
gi 42476320   125 DIDECEVSG-LCRHGGRCVNTHGSFECYCMDG 155
Cdd:pfam07645   1 DVDECATGThNCPANTVCVNTIGSFECRCPDG 32

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.

                          10        20
                  ....*....|....*....|....*...
gi 42476320    42 CHEHATCQQREGKKICICNYGFVGNGRT 69
Cdd:pfam12947   8 CHPNATCTNTGGSFTCTCNDGYTGDGVT 35

Sushi repeat (SCR repeat);

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 42476320   239 CGNPPEMRHAILVGNHSS-RLGGVARYVCQEGFESPGGkITSVCTEKGTWRESTLTC 294
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEyNYGASVSYECDPGYRLVGS-PTITCQEDGTWSPPFPEC 56

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                        10        20        30
                ....*....|....*....|....*....|....*.
gi 42476320 125 DIDECEVSGLCRHGGRCVNTHGSFECYCMDGYLPRN 160
Cdd:cd00054   1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 42476320 179 CGTPPEVPDGYIIGNYTS-SLGSQVRYACREGFFSVPEDTVsSCTGLGTWESPKLHCQ 235
Cdd:cd00033   1 CPPPPVPENGTVTGSKGSySYGSTVTYSCNEGYTLVGSSTI-TCTENGGWSPPPPTCE 57

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.

                        10        20
                ....*....|....*....|....*....
gi 42476320 128 ECEVSGLCRHGGRCVNTHGSFECYCMDGY 156
Cdd:cd00053   1 ECAASNPCSNGGTCVNTPGSYRCVCPPGY 29

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 42476320    179 CGTPPEVPDGYIIG-NYTSSLGSQVRYACREGFFSVPEDTvSSCTGLGTWESPKLHC 234
Cdd:smart00032   1 CPPPPDIENGTVTSsSGTYSYGDTVTYSCDPGYTLIGSST-ITCLENGTWSPPPPTC 56

secreted complement-binding protein; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476320  101 ICLEGYRATNNNKTFIPNDGTFCTDIDEC----------------EVSGL---------CRHGGRCVnthGSFECYCMDG 155
Cdd:PHA02927  53 LCLPGYRKQKMGPIYAKCTGTGWTLFNQCikrrcpsprdidngqlDIGGVdfgssitysCNSGYQLI---GESKSYCELG 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476320  156 YlprNGPEPFHPttDATSCTEIDCGTPPEVPDGYIIGN---YTSslGSQVRYACREGfFSVPEDTVSSCTGlGTWESPKL 232
Cdd:PHA02927 130 S---TGSMVWNP--EAPICESVKCQSPPSISNGRHNGYedfYTD--GSVVTYSCNSG-YSLIGNSGVLCSG-GEWSDPPT 200

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 42476320  233 hCQEINCGNPPEMRHAILVG-NHSSRLGGVARYVCQEGFESPGGKiTSVCTEKGTWRESTLTC 294
Cdd:PHA02927 201 -CQIVKCPHPTISNGYLSSGfKRSYSYNDNVDFKCKYGYKLSGSS-SSTCSPGNTWQPELPKC 261

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 42476320    239 CGNPPEMRHA-ILVGNHSSRLGGVARYVCQEGFESPGGKiTSVCTEKGTWRESTLTC 294
Cdd:smart00032   1 CPPPPDIENGtVTSSSGTYSYGDTVTYSCDPGYTLIGSS-TITCLENGTWSPPPPTC 56

Calcium-binding EGF domain;

                          10        20        30
                  ....*....|....*....|....*....|...
gi 42476320    73 DKNECQFGaTLVCGNHTSCHNTPGGFYCICLEG 105
Cdd:pfam07645   1 DVDECATG-THNCPANTVCVNTIGSFECRCPDG 32

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.

                        10        20
                ....*....|....*....|...
gi 42476320  85 CGNHTSCHNTPGGFYCICLEGYR 107
Cdd:cd00053   8 CSNGGTCVNTPGSYRCVCPPGYT 30

EEV host range protein; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476320  168 TTDATSCTEIDCGTPPEVPDGYIIGNYTS-SLGSQVRYACREGF---FSVPEDTVSSCTGLGTWESPKLHCQEINCgNPP 243
Cdd:PHA02639  74 SNKAPFCMLKECNDPPSIINGKIYNKREMyKVGDEIYYVCNEHKgvqYSLVGNEKITCIQDKSWKPDPPICKMINC-RFP 152

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 42476320  244 EMRHAILVG-------NHSSRLGgvarYVCQEGFESPGGKItSVCTEKGTWRESTLTC 294
Cdd:PHA02639 153 ALQNGYINGipsnkkfYYKTRVG----FSCKSGFDLVGEKY-STCNINATWFPSIPTC 205

EEV Host range protein; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42476320  172 TSCTEIDCGTPPEVPDGYIIGNYTS-SLGSQVRYACREGFFSVPEDTVSS----CTGLGTWESPKLHCQEINCgNPPEMR 246
Cdd:PHA02817  17 SLCDLNKCCYPPSIKNGYIYNKKTEyNIGSNVTFFCGNNTRGVRYTLVGEkniiCEKDGKWNKEFPVCKIIRC-RFPALQ 95

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 42476320  247 HAILVGNHSSR---LGGVARYVCQEGFESPGGKItSVCTEKGTW 287
Cdd:PHA02817  96 NGFVNGIPDSKkfyYESEVSFSCKPGFVLIGTKY-SVCGINSSW 138