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Conserved domains on  [gi|23618867|ref|NP_073591|]
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sideroflexin-1 isoform 1 [Homo sapiens]

Protein Classification

sideroflexin family transporter( domain architecture ID 10510848)

sideroflexin family transporter is a mitochondrial membrane protein implicated in one-carbon metabolism; similar to sideroflexin-1, which acts as a mitochondrial serine transporter

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SFXNs pfam03820
Sideroflexins; This family contains sideroflexin 1, 2 and 3 (SFXN1/2/3). SFXN1 is a multipass ...
10-322 0e+00

Sideroflexins; This family contains sideroflexin 1, 2 and 3 (SFXN1/2/3). SFXN1 is a multipass mitochondrial membrane protein and is part of the sideroflexin family of proteins conserved throughout eukaryotes. In humans, SFXN1 is highly expressed in the blood, liver, and kidney, which are tissues with high one-carbon metabolism activity. SFXN1 functions as a mitochondrial serine transporter in one-carbon metabolism. SFXN1 and SFXN3 (and perhaps SFXN2) are the main mitochondrial serine transporters in human cells and Sfxn1-3 also have this function in D. melanogaster. SFXN1 and SFXN3 likely have other physiologically relevant substrates besides serine, such as alanine or cysteine. Because SFXN1 is expressed in many cancers most highly in leukemias and lymphomas and its expression is likely regulated by the Myc transcription factor, it is suggested that it may have roles in cancer cell growth. Furthermore, Myc-binding sites were found in the promoters of SFXN1, SFXN2, and SFXN3.


:

Pssm-ID: 461063  Cd Length: 319  Bit Score: 559.05  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23618867    10 NIKEPRWDQSTFIGRANHFFTVTDPRNILLTNEQLESARKIVHDYRQGIVPPGLTENELWRAKYIYDSAFHPDTGEKMIL 89
Cdd:pfam03820   1 DLDKPRWDQSTYWGRLKHFFDITDPRTLLASDAELEEAKELVDDYKKGKEPPGTTEEELWRAKKLYDSAFHPDTGEKIFL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23618867    90 IGRMSAQVPMNMTITGCMMTFYRTTPAVLFWQWINQSFNAVVNYTNRSGDAPLTVNELGTAYVSATTGAVATALGLNALT 169
Cdd:pfam03820  81 PFRMSAQVPMNMPITGGMLTPYKTTPAVIFWQWVNQSFNAAVNYANRNASSPMSTSQLAQAYVAAVTAACGVALGLNSLV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23618867   170 KH--VSP----LIGRFVPFAAVAAANCINIPLMRQRELKVGIPVTDENGNRLGESANAAKQAITQVVVSRILMAAPGMAI 243
Cdd:pfam03820 161 KRlkLSPatrlLLGRLVPFAAVAAANCVNIPLMRSKELRNGIDVFDEDGNVVGKSKKAAKKAVGQVALSRVLMAAPGMVI 240
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 23618867   244 PPFIMNTLEKKAFLKRFPWMSAPIQVGLVGFCLVFATPLCCALFPQKSSMSVTSLEAELQAKIQESHPELRRVYFNKGL 322
Cdd:pfam03820 241 PPLIMNRLEKTGFLKRRPWLHAPIQLGLIGLCLGFALPLACALFPQRSSISVSKLEPEFQELIKKKGGPPTTVYFNKGL 319
 
Name Accession Description Interval E-value
SFXNs pfam03820
Sideroflexins; This family contains sideroflexin 1, 2 and 3 (SFXN1/2/3). SFXN1 is a multipass ...
10-322 0e+00

Sideroflexins; This family contains sideroflexin 1, 2 and 3 (SFXN1/2/3). SFXN1 is a multipass mitochondrial membrane protein and is part of the sideroflexin family of proteins conserved throughout eukaryotes. In humans, SFXN1 is highly expressed in the blood, liver, and kidney, which are tissues with high one-carbon metabolism activity. SFXN1 functions as a mitochondrial serine transporter in one-carbon metabolism. SFXN1 and SFXN3 (and perhaps SFXN2) are the main mitochondrial serine transporters in human cells and Sfxn1-3 also have this function in D. melanogaster. SFXN1 and SFXN3 likely have other physiologically relevant substrates besides serine, such as alanine or cysteine. Because SFXN1 is expressed in many cancers most highly in leukemias and lymphomas and its expression is likely regulated by the Myc transcription factor, it is suggested that it may have roles in cancer cell growth. Furthermore, Myc-binding sites were found in the promoters of SFXN1, SFXN2, and SFXN3.


Pssm-ID: 461063  Cd Length: 319  Bit Score: 559.05  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23618867    10 NIKEPRWDQSTFIGRANHFFTVTDPRNILLTNEQLESARKIVHDYRQGIVPPGLTENELWRAKYIYDSAFHPDTGEKMIL 89
Cdd:pfam03820   1 DLDKPRWDQSTYWGRLKHFFDITDPRTLLASDAELEEAKELVDDYKKGKEPPGTTEEELWRAKKLYDSAFHPDTGEKIFL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23618867    90 IGRMSAQVPMNMTITGCMMTFYRTTPAVLFWQWINQSFNAVVNYTNRSGDAPLTVNELGTAYVSATTGAVATALGLNALT 169
Cdd:pfam03820  81 PFRMSAQVPMNMPITGGMLTPYKTTPAVIFWQWVNQSFNAAVNYANRNASSPMSTSQLAQAYVAAVTAACGVALGLNSLV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23618867   170 KH--VSP----LIGRFVPFAAVAAANCINIPLMRQRELKVGIPVTDENGNRLGESANAAKQAITQVVVSRILMAAPGMAI 243
Cdd:pfam03820 161 KRlkLSPatrlLLGRLVPFAAVAAANCVNIPLMRSKELRNGIDVFDEDGNVVGKSKKAAKKAVGQVALSRVLMAAPGMVI 240
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 23618867   244 PPFIMNTLEKKAFLKRFPWMSAPIQVGLVGFCLVFATPLCCALFPQKSSMSVTSLEAELQAKIQESHPELRRVYFNKGL 322
Cdd:pfam03820 241 PPLIMNRLEKTGFLKRRPWLHAPIQLGLIGLCLGFALPLACALFPQRSSISVSKLEPEFQELIKKKGGPPTTVYFNKGL 319
mtc TIGR00798
tricarboxylate carrier; The MTC family consists of a limited number of homologues, all from ...
7-322 0e+00

tricarboxylate carrier; The MTC family consists of a limited number of homologues, all from eukaryotes. A single member of the family has been functionally characterized, the tricarboxylate carrier from rat liver mitochondria. The rat liver mitochondrial tricarboxylate carrier has been reported to transport citrate, cis-aconitate, threo-D-isocitrate, D- and L-tartrate, malate, succinate and phosphoenolpyruvate. It presumably functions by a proton symport mechanism. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 129880  Cd Length: 318  Bit Score: 518.84  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23618867     7 PNINIKEPRWDQSTFIGRANHFFTVTDPRNILLTNEQLESARKIVHDYRQGIVPPgLTENELWRAKYIYDSAFHPDTGEK 86
Cdd:TIGR00798   1 PTFDISKPRWDQSTFLGRARHFFEITNPLTLFSSEKQLEKAREIVEDYKAGKASP-LTVDELWRAKKLYDSAFHPDTGEK 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23618867    87 MILIGRMSAQVPMNMTITGCMMTFYRTTPAVLFWQWINQSFNAVVNYTNRSGDAPLTVNELGTAYVSATTGAVATALGLN 166
Cdd:TIGR00798  80 MFLPGRMSAQVPMNMVITGGMLTPYRSTPGVVFWQWINQSFNAAVNYTNRSGDSPLTLSQLLVSYCAAVTGACGVALGLN 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23618867   167 ALTKHV---SPLIGRFVPFAAVAAANCINIPLMRQRELKVGIPVTDENGNRLGESANAAKQAITQVVVSRILMAAPGMAI 243
Cdd:TIGR00798 160 MMVKKSpslSPLIGRLVPFAAVAVANAINIPMMRGNELTEGIEVFDEDGETVGKSKKAAALAIAQVVLSRVIMAVPDMVM 239
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 23618867   244 PPFIMNTLEKKAFLKRFPWMSAPIQVGLVGFCLVFATPLCCALFPQKSSMSVTSLEAELQAKIQESHPELRRVYFNKGL 322
Cdd:TIGR00798 240 PPLIMNRLERTAWLRARPWMQIPIQTLLCGLGLAFATPLACALFPQKSAISVDKLEPSLQNLIQKLGNPPKVVYYNKGL 318
 
Name Accession Description Interval E-value
SFXNs pfam03820
Sideroflexins; This family contains sideroflexin 1, 2 and 3 (SFXN1/2/3). SFXN1 is a multipass ...
10-322 0e+00

Sideroflexins; This family contains sideroflexin 1, 2 and 3 (SFXN1/2/3). SFXN1 is a multipass mitochondrial membrane protein and is part of the sideroflexin family of proteins conserved throughout eukaryotes. In humans, SFXN1 is highly expressed in the blood, liver, and kidney, which are tissues with high one-carbon metabolism activity. SFXN1 functions as a mitochondrial serine transporter in one-carbon metabolism. SFXN1 and SFXN3 (and perhaps SFXN2) are the main mitochondrial serine transporters in human cells and Sfxn1-3 also have this function in D. melanogaster. SFXN1 and SFXN3 likely have other physiologically relevant substrates besides serine, such as alanine or cysteine. Because SFXN1 is expressed in many cancers most highly in leukemias and lymphomas and its expression is likely regulated by the Myc transcription factor, it is suggested that it may have roles in cancer cell growth. Furthermore, Myc-binding sites were found in the promoters of SFXN1, SFXN2, and SFXN3.


Pssm-ID: 461063  Cd Length: 319  Bit Score: 559.05  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23618867    10 NIKEPRWDQSTFIGRANHFFTVTDPRNILLTNEQLESARKIVHDYRQGIVPPGLTENELWRAKYIYDSAFHPDTGEKMIL 89
Cdd:pfam03820   1 DLDKPRWDQSTYWGRLKHFFDITDPRTLLASDAELEEAKELVDDYKKGKEPPGTTEEELWRAKKLYDSAFHPDTGEKIFL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23618867    90 IGRMSAQVPMNMTITGCMMTFYRTTPAVLFWQWINQSFNAVVNYTNRSGDAPLTVNELGTAYVSATTGAVATALGLNALT 169
Cdd:pfam03820  81 PFRMSAQVPMNMPITGGMLTPYKTTPAVIFWQWVNQSFNAAVNYANRNASSPMSTSQLAQAYVAAVTAACGVALGLNSLV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23618867   170 KH--VSP----LIGRFVPFAAVAAANCINIPLMRQRELKVGIPVTDENGNRLGESANAAKQAITQVVVSRILMAAPGMAI 243
Cdd:pfam03820 161 KRlkLSPatrlLLGRLVPFAAVAAANCVNIPLMRSKELRNGIDVFDEDGNVVGKSKKAAKKAVGQVALSRVLMAAPGMVI 240
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 23618867   244 PPFIMNTLEKKAFLKRFPWMSAPIQVGLVGFCLVFATPLCCALFPQKSSMSVTSLEAELQAKIQESHPELRRVYFNKGL 322
Cdd:pfam03820 241 PPLIMNRLEKTGFLKRRPWLHAPIQLGLIGLCLGFALPLACALFPQRSSISVSKLEPEFQELIKKKGGPPTTVYFNKGL 319
mtc TIGR00798
tricarboxylate carrier; The MTC family consists of a limited number of homologues, all from ...
7-322 0e+00

tricarboxylate carrier; The MTC family consists of a limited number of homologues, all from eukaryotes. A single member of the family has been functionally characterized, the tricarboxylate carrier from rat liver mitochondria. The rat liver mitochondrial tricarboxylate carrier has been reported to transport citrate, cis-aconitate, threo-D-isocitrate, D- and L-tartrate, malate, succinate and phosphoenolpyruvate. It presumably functions by a proton symport mechanism. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 129880  Cd Length: 318  Bit Score: 518.84  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23618867     7 PNINIKEPRWDQSTFIGRANHFFTVTDPRNILLTNEQLESARKIVHDYRQGIVPPgLTENELWRAKYIYDSAFHPDTGEK 86
Cdd:TIGR00798   1 PTFDISKPRWDQSTFLGRARHFFEITNPLTLFSSEKQLEKAREIVEDYKAGKASP-LTVDELWRAKKLYDSAFHPDTGEK 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23618867    87 MILIGRMSAQVPMNMTITGCMMTFYRTTPAVLFWQWINQSFNAVVNYTNRSGDAPLTVNELGTAYVSATTGAVATALGLN 166
Cdd:TIGR00798  80 MFLPGRMSAQVPMNMVITGGMLTPYRSTPGVVFWQWINQSFNAAVNYTNRSGDSPLTLSQLLVSYCAAVTGACGVALGLN 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23618867   167 ALTKHV---SPLIGRFVPFAAVAAANCINIPLMRQRELKVGIPVTDENGNRLGESANAAKQAITQVVVSRILMAAPGMAI 243
Cdd:TIGR00798 160 MMVKKSpslSPLIGRLVPFAAVAVANAINIPMMRGNELTEGIEVFDEDGETVGKSKKAAALAIAQVVLSRVIMAVPDMVM 239
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 23618867   244 PPFIMNTLEKKAFLKRFPWMSAPIQVGLVGFCLVFATPLCCALFPQKSSMSVTSLEAELQAKIQESHPELRRVYFNKGL 322
Cdd:TIGR00798 240 PPLIMNRLERTAWLRARPWMQIPIQTLLCGLGLAFATPLACALFPQKSAISVDKLEPSLQNLIQKLGNPPKVVYYNKGL 318
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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