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Conserved domains on  [gi|31377705|ref|NP_078824|]
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centrosomal protein of 97 kDa isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 46-242 1.57e-24

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 102.56  E-value: 1.57e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377705  46 NQIIKLENLEKCKRLIQLSVANNRLVRMMGVAKLTLLRVLNLPHNSIGCVEGLKELVHLEWLNLAGNNLKAMEQI----N 121
Cdd:cd21340  34 NKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEELHIENQRLPPGEKLtfdpR 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377705 122 SCTA----LQHLDLSDNNISQIGDLSKLVSLKTLLlhgniitslrmapaylprslailsLAENEIRDLNEIS-FLASLTE 196
Cdd:cd21340 114 SLAAlsnsLRVLNISGNNIDSLEPLAPLRNLEQLD------------------------ASNNQISDLEELLdLLSSWPS 169

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 31377705 197 LEQLSIMNNPcVMATPSipgfdYRPYIVSWCLNLRVLDGYVISQKE 242
Cdd:cd21340 170 LRELDLTGNP-VCKKPK-----YRDKIILASKSLEVLDGKEITDTE 209
IQCD cd23767
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ...
 555-575 1.99e-04

IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.


:

Pssm-ID: 467745 [Multi-domain]  Cd Length: 37  Bit Score: 39.45  E-value: 1.99e-04
                        10        20
                ....*....|....*....|.
gi 31377705 555 LQKLNDAATKLQACWRGFYAR 575
Cdd:cd23767   5 LQRMNRAATLIQALWRGYKVR 25
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 46-242 1.57e-24

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 102.56  E-value: 1.57e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377705  46 NQIIKLENLEKCKRLIQLSVANNRLVRMMGVAKLTLLRVLNLPHNSIGCVEGLKELVHLEWLNLAGNNLKAMEQI----N 121
Cdd:cd21340  34 NKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEELHIENQRLPPGEKLtfdpR 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377705 122 SCTA----LQHLDLSDNNISQIGDLSKLVSLKTLLlhgniitslrmapaylprslailsLAENEIRDLNEIS-FLASLTE 196
Cdd:cd21340 114 SLAAlsnsLRVLNISGNNIDSLEPLAPLRNLEQLD------------------------ASNNQISDLEELLdLLSSWPS 169

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 31377705 197 LEQLSIMNNPcVMATPSipgfdYRPYIVSWCLNLRVLDGYVISQKE 242
Cdd:cd21340 170 LRELDLTGNP-VCKKPK-----YRDKIILASKSLEVLDGKEITDTE 209
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
40-205 1.59e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 95.00  E-value: 1.59e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377705  40 TLILDKNQIIKLENLEKCKRLIQLSVANNRlvrmmGVAKLTLLRVLNLPHNSIGCV-EGLKELVHLEWLNLAGNNLKAM- 117
Cdd:COG4886  78 SLLLLSLLLLGLTDLGDLTNLTELDLSGNE-----ELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLp 152

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377705 118 EQINSCTALQHLDLSDNNISQIGD-LSKLVSLKTLLLHGNIITSLRMAPAYLPrSLAILSLAENEIRDLNEisFLASLTE 196
Cdd:COG4886 153 EPLGNLTNLKSLDLSNNQLTDLPEeLGNLTNLKELDLSNNQITDLPEPLGNLT-NLEELDLSGNQLTDLPE--PLANLTN 229


                ....*....
gi 31377705 197 LEQLSIMNN 205
Cdd:COG4886 230 LETLDLSNN 238
LRR_9 pfam14580
Leucine-rich repeat;
107-256 1.50e-11

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 63.63  E-value: 1.50e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377705   107 LNLAGNNLKAMEQIN-SCTALQHLDLSDNNISQIGDLSKLVSLKTLLLHGNIItsLRMAPA---YLPrSLAILSLAENEI 182
Cdd:pfam14580  24 LDLRGYKIPIIENLGaTLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRI--CRIGEGlgeALP-NLTELILTNNNL 100

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 31377705   183 RDLNEISFLASLTELEQLSIMNNPcVMATPsipgfDYRPYIVSWCLNLRVLDGYVISQKESLKAEWLYSQGKGR 256
Cdd:pfam14580 101 QELGDLDPLASLKKLTFLSLLRNP-VTNKP-----HYRLYVIYKVPQLRLLDFRKVKQKERQAAEKMFRSKQGK 168
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
38-198 4.63e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 57.01  E-value: 4.63e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377705   38 IHTLILDKNQIIKL-ENLEKckRLIQLSVANNRLVRM-------MGVAKLTLLRVLNLP-------------HNSIGCV- 95
Cdd:PRK15370 201 ITTLILDNNELKSLpENLQG--NIKTLYANSNQLTSIpatlpdtIQEMELSINRITELPerlpsalqsldlfHNKISCLp 278

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377705   96 EGLKElvHLEWLNLAGNNLKAM-EQINSctALQHLDLSDNNISQIGDLSKLvSLKTLLLHGNIITSLrmaPAYLPRSLAI 174
Cdd:PRK15370 279 ENLPE--ELRYLSVYDNSIRTLpAHLPS--GITHLNVQSNSLTALPETLPP-GLKTLEAGENALTSL---PASLPPELQV 350

                        170       180
                 ....*....|....*....|....
gi 31377705  175 LSLAENEIRDLNEiSFLASLTELE 198
Cdd:PRK15370 351 LDVSKNQITVLPE-TLPPTITTLD 373
IQCD cd23767
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ...
 555-575 1.99e-04

IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.


Pssm-ID: 467745 [Multi-domain]  Cd Length: 37  Bit Score: 39.45  E-value: 1.99e-04
                        10        20
                ....*....|....*....|.
gi 31377705 555 LQKLNDAATKLQACWRGFYAR 575
Cdd:cd23767   5 LQRMNRAATLIQALWRGYKVR 25
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 46-242 1.57e-24

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 102.56  E-value: 1.57e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377705  46 NQIIKLENLEKCKRLIQLSVANNRLVRMMGVAKLTLLRVLNLPHNSIGCVEGLKELVHLEWLNLAGNNLKAMEQI----N 121
Cdd:cd21340  34 NKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEELHIENQRLPPGEKLtfdpR 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377705 122 SCTA----LQHLDLSDNNISQIGDLSKLVSLKTLLlhgniitslrmapaylprslailsLAENEIRDLNEIS-FLASLTE 196
Cdd:cd21340 114 SLAAlsnsLRVLNISGNNIDSLEPLAPLRNLEQLD------------------------ASNNQISDLEELLdLLSSWPS 169

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 31377705 197 LEQLSIMNNPcVMATPSipgfdYRPYIVSWCLNLRVLDGYVISQKE 242
Cdd:cd21340 170 LRELDLTGNP-VCKKPK-----YRDKIILASKSLEVLDGKEITDTE 209
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
40-205 1.59e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 95.00  E-value: 1.59e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377705  40 TLILDKNQIIKLENLEKCKRLIQLSVANNRlvrmmGVAKLTLLRVLNLPHNSIGCV-EGLKELVHLEWLNLAGNNLKAM- 117
Cdd:COG4886  78 SLLLLSLLLLGLTDLGDLTNLTELDLSGNE-----ELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLp 152

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377705 118 EQINSCTALQHLDLSDNNISQIGD-LSKLVSLKTLLLHGNIITSLRMAPAYLPrSLAILSLAENEIRDLNEisFLASLTE 196
Cdd:COG4886 153 EPLGNLTNLKSLDLSNNQLTDLPEeLGNLTNLKELDLSNNQITDLPEPLGNLT-NLEELDLSGNQLTDLPE--PLANLTN 229


                ....*....
gi 31377705 197 LEQLSIMNN 205
Cdd:COG4886 230 LETLDLSNN 238
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
40-206 3.11e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 88.07  E-value: 3.11e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377705  40 TLILDKNQIIKL-ENLEKCKRLIQLSVANNRLVRM-MGVAKLTLLRVLNLPHNSIGCV-EGLKELVHLEWLNLAGNNLKA 116
Cdd:COG4886 163 SLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTD 242

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377705 117 MEQINSCTALQHLDLSDNNISQIGDLSKLVSLKTLLLHGNIITSLRMAPAYLPRSLAILSLAENEIRDLNEISFLASLTE 196
Cdd:COG4886 243 LPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTT 322

                       170
                ....*....|
gi 31377705 197 LEQLSIMNNP 206
Cdd:COG4886 323 LLLLLLLLKG 332
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
40-206 4.93e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.97  E-value: 4.93e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377705  40 TLILDKNQIIKL-ENLEKCKRLIQLSVANNRLVRM-MGVAKLTLLRVLNLPHNSIGCVEGLKELVHLEWLNLAGNNLKAM 117
Cdd:COG4886 186 ELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDL 265

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377705 118 EQINSCTALQHLDLSDNNIS--QIGDLSKLVSLKTLLLHGNIITSLRMAPAYLPRSLAILSLAENEIRDLNEISFLASLT 195
Cdd:COG4886 266 PPLANLTNLKTLDLSNNQLTdlKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLS 345

                       170
                ....*....|.
gi 31377705 196 ELEQLSIMNNP 206
Cdd:COG4886 346 LLALLTLLLLL 356
LRR_9 pfam14580
Leucine-rich repeat;
107-256 1.50e-11

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 63.63  E-value: 1.50e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377705   107 LNLAGNNLKAMEQIN-SCTALQHLDLSDNNISQIGDLSKLVSLKTLLLHGNIItsLRMAPA---YLPrSLAILSLAENEI 182
Cdd:pfam14580  24 LDLRGYKIPIIENLGaTLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRI--CRIGEGlgeALP-NLTELILTNNNL 100

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 31377705   183 RDLNEISFLASLTELEQLSIMNNPcVMATPsipgfDYRPYIVSWCLNLRVLDGYVISQKESLKAEWLYSQGKGR 256
Cdd:pfam14580 101 QELGDLDPLASLKKLTFLSLLRNP-VTNKP-----HYRLYVIYKVPQLRLLDFRKVKQKERQAAEKMFRSKQGK 168
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
38-198 4.63e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 57.01  E-value: 4.63e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377705   38 IHTLILDKNQIIKL-ENLEKckRLIQLSVANNRLVRM-------MGVAKLTLLRVLNLP-------------HNSIGCV- 95
Cdd:PRK15370 201 ITTLILDNNELKSLpENLQG--NIKTLYANSNQLTSIpatlpdtIQEMELSINRITELPerlpsalqsldlfHNKISCLp 278

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377705   96 EGLKElvHLEWLNLAGNNLKAM-EQINSctALQHLDLSDNNISQIGDLSKLvSLKTLLLHGNIITSLrmaPAYLPRSLAI 174
Cdd:PRK15370 279 ENLPE--ELRYLSVYDNSIRTLpAHLPS--GITHLNVQSNSLTALPETLPP-GLKTLEAGENALTSL---PASLPPELQV 350

                        170       180
                 ....*....|....*....|....
gi 31377705  175 LSLAENEIRDLNEiSFLASLTELE 198
Cdd:PRK15370 351 LDVSKNQITVLPE-TLPPTITTLD 373
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
38-205 6.50e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 55.71  E-value: 6.50e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377705  38 IHTLILDKNQIIKLENLEKCKRLIQLSVANNRLVRMMGVAKLTLLRVLNLPHNSIGCVEGLKELVHLEWLNLAGNNLKAM 117
Cdd:COG4886  10 LKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGL 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377705 118 EQINSCTALQHLDLSDNNisqigDLSKLVSLKTLLLHGNIITSLRMAPAYLPrSLAILSLAENEIRDLNEisFLASLTEL 197
Cdd:COG4886  90 TDLGDLTNLTELDLSGNE-----ELSNLTNLESLDLSGNQLTDLPEELANLT-NLKELDLSNNQLTDLPE--PLGNLTNL 161


                ....*...
gi 31377705 198 EQLSIMNN 205
Cdd:COG4886 162 KSLDLSNN 169
LRR_8 pfam13855
Leucine rich repeat;
103-156 1.55e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 1.55e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 31377705   103 HLEWLNLAGNNLKAMEQ--INSCTALQHLDLSDNNISQI--GDLSKLVSLKTLLLHGN 156
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLspGAFSGLPSLRYLDLSGN 59
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 23-159 1.87e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 48.25  E-value: 1.87e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377705  23 QGLQKLGPNLPCEADIHTLILDKNQI-----IKL-ENLEKCKRLIQLSVANNRL----VRMM--GVAKLTLLRVLNLPHN 90
Cdd:COG5238 251 EGVIALAEALKNNTTVETLYLSGNQIgaegaIALaKALQGNTTLTSLDLSVNRIgdegAIALaeGLQGNKTLHTLNLAYN 330

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377705  91 SIG------CVEGLKELVHLEWLNLAGNNLKA------MEQINSCTALQHLDLSDNNISQIG-----DLSKLVSLKTLLL 153
Cdd:COG5238 331 GIGaqgaiaLAKALQENTTLHSLDLSDNQIGDegaialAKYLEGNTTLRELNLGKNNIGKQGaealiDALQTNRLHTLIL 410


                ....*.
gi 31377705 154 HGNIIT 159
Cdd:COG5238 411 DGNLIG 416
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 103-144 1.99e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 42.23  E-value: 1.99e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 31377705   103 HLEWLNLAGNNLKAMEQINSCTALQHLDLSDNN-ISQIGDLSK 144
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNkITDLSDLAN 44
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 78-200 2.04e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 47.35  E-value: 2.04e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377705  78 KLTLLRVLNLPHNSIG------CVEGLKELVHLEWLNLAGNNL-----KAM-EQINSCTALQHLDLSDNNISQIGdlskL 145
Cdd:cd00116 163 ANRDLKELNLANNGIGdagiraLAEGLKANCNLEVLDLNNNGLtdegaSALaETLASLKSLEVLNLGDNNLTDAG----A 238

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 31377705 146 VSLKTLLLHGNIitslrmapaylprSLAILSLAENEIRDLNEISFLASLTELEQL 200
Cdd:cd00116 239 AALASALLSPNI-------------SLLTLSLSCNDITDDGAKDLAEVLAEKESL 280
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 128-205 2.24e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 46.32  E-value: 2.24e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 31377705 128 HLDLSDNNISQIGDLSKLVSLKTLLLHGNIITSLRMAPAYlpRSLAILSLAENEIRdlnEISFLASLTELEQLSIMNN 205
Cdd:cd21340   6 HLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFL--TNLTHLYLQNNQIE---KIENLENLVNLKKLYLGGN 78
LRR_8 pfam13855
Leucine rich repeat;
147-206 5.13e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 5.13e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377705   147 SLKTLLLHGNIITSLRMAPAYLPRSLAILSLAENEIRDLNEISFlASLTELEQLSIMNNP 206
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAF-SGLPSLRYLDLSGNR 60
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 23-205 7.26e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 46.32  E-value: 7.26e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377705  23 QGLQKLGPNLPCEADIHTLILDKNQI------IKLENLEKCKRLIQLSVANNRLVR--MMGVAKL----TLLRVLNLPHN 90
Cdd:COG5238 195 EGIEELAEALTQNTTVTTLWLKRNPIgdegaeILAEALKGNKSLTTLDLSNNQIGDegVIALAEAlknnTTVETLYLSGN 274

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377705  91 SIGC------VEGLKELVHLEWLNLAGNNLKAMEQINSCTALQH------LDLSDNNISQIG------DLSKLVSLKTLL 152
Cdd:COG5238 275 QIGAegaialAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGnktlhtLNLAYNGIGAQGaialakALQENTTLHSLD 354

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377705 153 LHGNIIT-----SLRMAPAYLPrSLAILSLAENEIRDLNEISFLASL--TELEQLSIMNN 205
Cdd:COG5238 355 LSDNQIGdegaiALAKYLEGNT-TLRELNLGKNNIGKQGAEALIDALqtNRLHTLILDGN 413
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 124-161 9.21e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 40.69  E-value: 9.21e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 31377705   124 TALQHLDLSDNNISQIGDLSKLVSLKTL-LLHGNIITSL 161
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLdLSGNNKITDL 39
IQCD cd23767
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ...
 555-575 1.99e-04

IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.


Pssm-ID: 467745 [Multi-domain]  Cd Length: 37  Bit Score: 39.45  E-value: 1.99e-04
                        10        20
                ....*....|....*....|.
gi 31377705 555 LQKLNDAATKLQACWRGFYAR 575
Cdd:cd23767   5 LQRMNRAATLIQALWRGYKVR 25
LRR_8 pfam13855
Leucine rich repeat;
82-136 2.09e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.82  E-value: 2.09e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 31377705    82 LRVLNLPHNSIGCVEG--LKELVHLEWLNLAGNNLKAMEQ--INSCTALQHLDLSDNNI 136
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
38-201 2.52e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 44.54  E-value: 2.52e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377705  38 IHTLILDKNQIIKLENLEKCKRLIQLSVANNRLVRMMGVAKLTLLRVLNLPHNSIGCVEgLKELVHLEWLNLAGNNLKAM 117
Cdd:COG4886 230 LETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLK-LKELELLLGLNSLLLLLLLL 308

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377705 118 EQINSCTALQHLDLSDNNISQIGDLSKLVSLKTLLLHGNIITSLRMAPAYLPRSLAILSLAENEIRDLNEISFLASLTEL 197
Cdd:COG4886 309 NLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLT 388


                ....
gi 31377705 198 EQLS 201
Cdd:COG4886 389 LLLL 392
PLN03150 PLN03150
hypothetical protein; Provisional
 101-156 5.80e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 43.65  E-value: 5.80e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377705  101 LVHLEWLNLAGNNLKAM--EQINSCTALQHLDLSDN--NISQIGDLSKLVSLKTLLLHGN 156
Cdd:PLN03150 441 LRHLQSINLSGNSIRGNipPSLGSITSLEVLDLSYNsfNGSIPESLGQLTSLRILNLNGN 500
LRR_8 pfam13855
Leucine rich repeat;
63-114 1.67e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 1.67e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 31377705    63 LSVANNRLVRMMGVA--KLTLLRVLNLPHNSIGCVEG--LKELVHLEWLNLAGNNL 114
Cdd:pfam13855   6 LDLSNNRLTSLDDGAfkGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 76-205 1.79e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.14  E-value: 1.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377705   76 VAKLTLLRVLNLPHNSI--GCVEGLKELVHLEWLNLAGNNLKAM--EQINSCTALQHLDLSDNNI-----SQIGDLSKlv 146
Cdd:PLN00113 184 LTNLTSLEFLTLASNQLvgQIPRELGQMKSLKWIYLGYNNLSGEipYEIGGLTSLNHLDLVYNNLtgpipSSLGNLKN-- 261

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 31377705  147 sLKTLLLHGNIITSLRMAPAYLPRSLAILSLAEN----EIRDLneisfLASLTELEQLSIMNN 205
Cdd:PLN00113 262 -LQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNslsgEIPEL-----VIQLQNLEILHLFSN 318
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 104-182 7.97e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.83  E-value: 7.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31377705  104 LEWLNLAGNNLKAMEQINSCTALQHLDLSDNNIS-----QIGDLSklvSLKTLLLHGNIITSlrMAPAYLPR--SLAILS 176
Cdd:PLN00113 120 LRYLNLSNNNFTGSIPRGSIPNLETLDLSNNMLSgeipnDIGSFS---SLKVLDLGGNVLVG--KIPNSLTNltSLEFLT 194


                 ....*.
gi 31377705  177 LAENEI 182
Cdd:PLN00113 195 LASNQL 200
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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