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Conserved domains on  [gi|151301150|ref|NP_079505|]
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protein sel-1 homolog 2 isoform 3 precursor [Homo sapiens]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11434433)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

Gene Ontology:  GO:0005515
PubMed:  10517866|30708253

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
282-476 1.37e-47

TPR repeat [General function prediction only];


:

Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 168.18  E-value: 1.37e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151301150 282 WDIYQYYKFLAERGDVQIQVSLGQLHLIGRkGLDQDYYKALHYFLKAAKAGSANAMAFIGKMYLEGNAaVPQNNATAFKY 361
Cdd:COG0790   48 AAAAAAAAAAAAAGGAEAQYNLGLMYAEGR-GVPKDYEKALEWFEKAAEQGDAEAQYNLGLMYEEGLG-VPQDYAKALEW 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151301150 362 FSMAASKGNAIGLHGLGLLYFHGKGVPLNYAEALKYFQKAAEKGWPDAQFQLGFMYYSGSGIWKDYKLAFKYFYLASQSG 441
Cdd:COG0790  126 YEKAAEQGDADAQYNLGLLYLNGEGVPKDPAKAAEWYRKAAEQGDADAQYNLGVLYENGRGVPKDPAKALEWYRKAAEQG 205

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 151301150 442 QPLAIYYLAKMYATGTGVVRSCRTAVELYKGVCEL 476
Cdd:COG0790  206 DADAQYNLGRLYLNGEGVEKDLEKALRWLRKAAEQ 240
TPR COG0790
TPR repeat [General function prediction only];
124-331 2.29e-19

TPR repeat [General function prediction only];


:

Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 88.06  E-value: 2.29e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151301150 124 QKQKEEAYLLFAKAADMGNLKAMEKMADALLFGNFGVQNITAAIQLYESLAKEGSCKAQNALGFLSSYGIGMEYDQAKAL 203
Cdd:COG0790   80 PKDYEKALEWFEKAAEQGDAEAQYNLGLMYEEGLGVPQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGEGVPKDPAKAA 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151301150 204 IYYTFGSAGGNMMSQMILGYRYLSGINVLQNCEVALSYYKKVadyiadtfeksegvpvekvrlterpenlssnseildwd 283
Cdd:COG0790  160 EWYRKAAEQGDADAQYNLGVLYENGRGVPKDPAKALEWYRKA-------------------------------------- 201

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 151301150 284 iyqyykflAERGDVQIQVSLGQLHLIGRkGLDQDYYKALHYFLKAAKA 331
Cdd:COG0790  202 --------AEQGDADAQYNLGRLYLNGE-GVEKDLEKALRWLRKAAEQ 240
TPR COG0790
TPR repeat [General function prediction only];
498-625 2.65e-13

TPR repeat [General function prediction only];


:

Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 69.96  E-value: 2.65e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151301150 498 SLVQYALLAEMGYEVAQSNSAFILESKKANILEKEKMYPMALLLWNRAAIQGNAFARVKIGDYHYYGYGTKKDYQTAATH 577
Cdd:COG0790   10 AAAAAAAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVPKDYEKALEW 89

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 151301150 578 YSIAANKyHNAQAMFNLAYMYEHGLGITKDIHLARRLYDMAA-QTSPDA 625
Cdd:COG0790   90 FEKAAEQ-GDAEAQYNLGLMYEEGLGVPQDYAKALEWYEKAAeQGDADA 137
Mplasa_alph_rch super family cl37461
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 18-128 5.82e-05

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


The actual alignment was detected with superfamily member TIGR04523:

Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 46.55  E-value: 5.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151301150   18 IKTIKAEEHNKRQKERNVTTQVS-----VNEIKQYLSHILEQRTSSNV--------INKRENLLEKKKNQRKIRIKGIQN 84
Cdd:TIGR04523 309 NKELKSELKNQEKKLEEIQNQISqnnkiISQLNEQISQLKKELTNSESensekqreLEEKQNEIEKLKKENQSYKQEIKN 388

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 151301150   85 kdiLKRNKNHLQKQAEKNftDEGDQLFKMGIKVLQQSKSQKQKE 128
Cdd:TIGR04523 389 ---LESQINDLESKIQNQ--EKLNQQKDEQIKKLQQEKELLEKE 427
 
Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
282-476 1.37e-47

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 168.18  E-value: 1.37e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151301150 282 WDIYQYYKFLAERGDVQIQVSLGQLHLIGRkGLDQDYYKALHYFLKAAKAGSANAMAFIGKMYLEGNAaVPQNNATAFKY 361
Cdd:COG0790   48 AAAAAAAAAAAAAGGAEAQYNLGLMYAEGR-GVPKDYEKALEWFEKAAEQGDAEAQYNLGLMYEEGLG-VPQDYAKALEW 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151301150 362 FSMAASKGNAIGLHGLGLLYFHGKGVPLNYAEALKYFQKAAEKGWPDAQFQLGFMYYSGSGIWKDYKLAFKYFYLASQSG 441
Cdd:COG0790  126 YEKAAEQGDADAQYNLGLLYLNGEGVPKDPAKAAEWYRKAAEQGDADAQYNLGVLYENGRGVPKDPAKALEWYRKAAEQG 205

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 151301150 442 QPLAIYYLAKMYATGTGVVRSCRTAVELYKGVCEL 476
Cdd:COG0790  206 DADAQYNLGRLYLNGEGVEKDLEKALRWLRKAAEQ 240
TPR COG0790
TPR repeat [General function prediction only];
124-331 2.29e-19

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 88.06  E-value: 2.29e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151301150 124 QKQKEEAYLLFAKAADMGNLKAMEKMADALLFGNFGVQNITAAIQLYESLAKEGSCKAQNALGFLSSYGIGMEYDQAKAL 203
Cdd:COG0790   80 PKDYEKALEWFEKAAEQGDAEAQYNLGLMYEEGLGVPQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGEGVPKDPAKAA 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151301150 204 IYYTFGSAGGNMMSQMILGYRYLSGINVLQNCEVALSYYKKVadyiadtfeksegvpvekvrlterpenlssnseildwd 283
Cdd:COG0790  160 EWYRKAAEQGDADAQYNLGVLYENGRGVPKDPAKALEWYRKA-------------------------------------- 201

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 151301150 284 iyqyykflAERGDVQIQVSLGQLHLIGRkGLDQDYYKALHYFLKAAKA 331
Cdd:COG0790  202 --------AEQGDADAQYNLGRLYLNGE-GVEKDLEKALRWLRKAAEQ 240
TPR COG0790
TPR repeat [General function prediction only];
498-625 2.65e-13

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 69.96  E-value: 2.65e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151301150 498 SLVQYALLAEMGYEVAQSNSAFILESKKANILEKEKMYPMALLLWNRAAIQGNAFARVKIGDYHYYGYGTKKDYQTAATH 577
Cdd:COG0790   10 AAAAAAAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVPKDYEKALEW 89

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 151301150 578 YSIAANKyHNAQAMFNLAYMYEHGLGITKDIHLARRLYDMAA-QTSPDA 625
Cdd:COG0790   90 FEKAAEQ-GDAEAQYNLGLMYEEGLGVPQDYAKALEWYEKAAeQGDADA 137
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 588-620 1.54e-06

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 44.82  E-value: 1.54e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 151301150  588 AQAMFNLAYMYEHGLGITKDIHLARRLYDMAAQ 620
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAE 33
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 588-620 1.71e-06

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 44.86  E-value: 1.71e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 151301150   588 AQAMFNLAYMYEHGLGITKDIHLARRLYDMAAQ 620
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAE 33
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 407-441 2.46e-06

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 44.47  E-value: 2.46e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 151301150   407 PDAQFQLGFMYYSGSGIWKDYKLAFKYFYLASQSG 441
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELG 35
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 371-405 6.99e-06

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 43.28  E-value: 6.99e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 151301150  371 AIGLHGLGLLYFHGKGVPLNYAEALKYFQKAAEKG 405
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 18-128 5.82e-05

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 46.55  E-value: 5.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151301150   18 IKTIKAEEHNKRQKERNVTTQVS-----VNEIKQYLSHILEQRTSSNV--------INKRENLLEKKKNQRKIRIKGIQN 84
Cdd:TIGR04523 309 NKELKSELKNQEKKLEEIQNQISqnnkiISQLNEQISQLKKELTNSESensekqreLEEKQNEIEKLKKENQSYKQEIKN 388

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 151301150   85 kdiLKRNKNHLQKQAEKNftDEGDQLFKMGIKVLQQSKSQKQKE 128
Cdd:TIGR04523 389 ---LESQINDLESKIQNQ--EKLNQQKDEQIKKLQQEKELLEKE 427
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 216-247 9.10e-03

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 34.46  E-value: 9.10e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 151301150   216 MSQMILGYRYLSGINVLQNCEVALSYYKKVAD 247
Cdd:smart00671   2 EAQYNLGQMYEYGLGVPKDLEKALEYYKKAAE 33
 
Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
282-476 1.37e-47

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 168.18  E-value: 1.37e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151301150 282 WDIYQYYKFLAERGDVQIQVSLGQLHLIGRkGLDQDYYKALHYFLKAAKAGSANAMAFIGKMYLEGNAaVPQNNATAFKY 361
Cdd:COG0790   48 AAAAAAAAAAAAAGGAEAQYNLGLMYAEGR-GVPKDYEKALEWFEKAAEQGDAEAQYNLGLMYEEGLG-VPQDYAKALEW 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151301150 362 FSMAASKGNAIGLHGLGLLYFHGKGVPLNYAEALKYFQKAAEKGWPDAQFQLGFMYYSGSGIWKDYKLAFKYFYLASQSG 441
Cdd:COG0790  126 YEKAAEQGDADAQYNLGLLYLNGEGVPKDPAKAAEWYRKAAEQGDADAQYNLGVLYENGRGVPKDPAKALEWYRKAAEQG 205

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 151301150 442 QPLAIYYLAKMYATGTGVVRSCRTAVELYKGVCEL 476
Cdd:COG0790  206 DADAQYNLGRLYLNGEGVEKDLEKALRWLRKAAEQ 240
TPR COG0790
TPR repeat [General function prediction only];
316-478 5.11e-39

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 144.30  E-value: 5.11e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151301150 316 QDYYKALHYFLKAAKAGSANAMAFIGKMYLEGNAaVPQNNATAFKYFSMAASKGNAIGLHGLGLLYFHGKGVPLNYAEAL 395
Cdd:COG0790   45 AGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRG-VPKDYEKALEWFEKAAEQGDAEAQYNLGLMYEEGLGVPQDYAKAL 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151301150 396 KYFQKAAEKGWPDAQFQLGFMYYSGSGIWKDYKLAFKYFYLASQSGQPLAIYYLAKMYATGTGVVRSCRTAVELYKGVCE 475
Cdd:COG0790  124 EWYEKAAEQGDADAQYNLGLLYLNGEGVPKDPAKAAEWYRKAAEQGDADAQYNLGVLYENGRGVPKDPAKALEWYRKAAE 203


                 ...
gi 151301150 476 LGH 478
Cdd:COG0790  204 QGD 206
TPR COG0790
TPR repeat [General function prediction only];
326-620 1.40e-37

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 140.06  E-value: 1.40e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151301150 326 LKAAKAGSANAMAFIGKMYLEGNAAVPQNNATAFKYFSMAASKGNAIGLHGLGLLYFHGKGVPLNYAEALKYFQKAAEKG 405
Cdd:COG0790   18 LAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVPKDYEKALEWFEKAAEQG 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151301150 406 WPDAQFQLGFMYYSGSGIWKDYKLAFKYFYLASQSGQPLAIYYLAKMYATGTGVVRSCRTAVELYKgvcelghwaekflt 485
Cdd:COG0790   98 DAEAQYNLGLMYEEGLGVPQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGEGVPKDPAKAAEWYR-------------- 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151301150 486 ayfaykdgdidsslvqyallaemgyevaqsnsafileskkanilekekmypmalllwnRAAIQGNAFARVKIGDYHYYGY 565
Cdd:COG0790  164 ----------------------------------------------------------KAAEQGDADAQYNLGVLYENGR 185

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 151301150 566 GTKKDYQTAATHYSIAANKyHNAQAMFNLAYMYEHGLGITKDIHLARRLYDMAAQ 620
Cdd:COG0790  186 GVPKDPAKALEWYRKAAEQ-GDADAQYNLGRLYLNGEGVEKDLEKALRWLRKAAE 239
TPR COG0790
TPR repeat [General function prediction only];
128-437 2.87e-33

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 128.12  E-value: 2.87e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151301150 128 EEAYLLFAKAADMGNLKAMEKMADALLFGNFGVQNITAAIQLYESLAKEGSCKAQNALGFLSSYGIGMEYDQAKALIYYT 207
Cdd:COG0790   12 AAAAAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVPKDYEKALEWFE 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151301150 208 FGSAGGNMMSQMILGYRYLSGinvlqncevalsyykkvadyiadtfeksegvpvekvrlterpenlssnseildwdiyqy 287
Cdd:COG0790   92 KAAEQGDAEAQYNLGLMYEEG----------------------------------------------------------- 112

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151301150 288 ykflaergdvqiqvslgqlhligrKGLDQDYYKALHYFLKAAKAGSANAMAFIGKMYLEGNaAVPQNNATAFKYFSMAAS 367
Cdd:COG0790  113 ------------------------LGVPQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGE-GVPKDPAKAAEWYRKAAE 167

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151301150 368 KGNAIGLHGLGLLYFHGKGVPLNYAEALKYFQKAAEKGWPDAQFQLGFMYYSGSGIWKDYKLAFKYFYLA 437
Cdd:COG0790  168 QGDADAQYNLGVLYENGRGVPKDPAKALEWYRKAAEQGDADAQYNLGRLYLNGEGVEKDLEKALRWLRKA 237
TPR COG0790
TPR repeat [General function prediction only];
124-331 2.29e-19

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 88.06  E-value: 2.29e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151301150 124 QKQKEEAYLLFAKAADMGNLKAMEKMADALLFGNFGVQNITAAIQLYESLAKEGSCKAQNALGFLSSYGIGMEYDQAKAL 203
Cdd:COG0790   80 PKDYEKALEWFEKAAEQGDAEAQYNLGLMYEEGLGVPQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGEGVPKDPAKAA 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151301150 204 IYYTFGSAGGNMMSQMILGYRYLSGINVLQNCEVALSYYKKVadyiadtfeksegvpvekvrlterpenlssnseildwd 283
Cdd:COG0790  160 EWYRKAAEQGDADAQYNLGVLYENGRGVPKDPAKALEWYRKA-------------------------------------- 201

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 151301150 284 iyqyykflAERGDVQIQVSLGQLHLIGRkGLDQDYYKALHYFLKAAKA 331
Cdd:COG0790  202 --------AEQGDADAQYNLGRLYLNGE-GVEKDLEKALRWLRKAAEQ 240
TPR COG0790
TPR repeat [General function prediction only];
498-625 2.65e-13

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 69.96  E-value: 2.65e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151301150 498 SLVQYALLAEMGYEVAQSNSAFILESKKANILEKEKMYPMALLLWNRAAIQGNAFARVKIGDYHYYGYGTKKDYQTAATH 577
Cdd:COG0790   10 AAAAAAAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVPKDYEKALEW 89

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 151301150 578 YSIAANKyHNAQAMFNLAYMYEHGLGITKDIHLARRLYDMAA-QTSPDA 625
Cdd:COG0790   90 FEKAAEQ-GDAEAQYNLGLMYEEGLGVPQDYAKALEWYEKAAeQGDADA 137
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 588-620 1.54e-06

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 44.82  E-value: 1.54e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 151301150  588 AQAMFNLAYMYEHGLGITKDIHLARRLYDMAAQ 620
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAE 33
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 588-620 1.71e-06

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 44.86  E-value: 1.71e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 151301150   588 AQAMFNLAYMYEHGLGITKDIHLARRLYDMAAQ 620
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAE 33
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 407-441 2.46e-06

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 44.47  E-value: 2.46e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 151301150   407 PDAQFQLGFMYYSGSGIWKDYKLAFKYFYLASQSG 441
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELG 35
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 371-405 3.67e-06

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 44.09  E-value: 3.67e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 151301150   371 AIGLHGLGLLYFHGKGVPLNYAEALKYFQKAAEKG 405
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELG 35
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 371-405 6.99e-06

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 43.28  E-value: 6.99e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 151301150  371 AIGLHGLGLLYFHGKGVPLNYAEALKYFQKAAEKG 405
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
TPR COG0790
TPR repeat [General function prediction only];
531-620 4.12e-05

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 45.69  E-value: 4.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151301150 531 KEKMYPMALLLWNRAAIQGNAFARVKIGDYHYYGYGTKKDYQTAATHYSIAANKYHNAQAMFNLAYMYEHGLGITKDIHL 610
Cdd:COG0790    6 AAAAAAAAAAAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVPKDYEK 85

                         90
                 ....*....|
gi 151301150 611 ARRLYDMAAQ 620
Cdd:COG0790   86 ALEWFEKAAE 95
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 18-128 5.82e-05

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 46.55  E-value: 5.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151301150   18 IKTIKAEEHNKRQKERNVTTQVS-----VNEIKQYLSHILEQRTSSNV--------INKRENLLEKKKNQRKIRIKGIQN 84
Cdd:TIGR04523 309 NKELKSELKNQEKKLEEIQNQISqnnkiISQLNEQISQLKKELTNSESensekqreLEEKQNEIEKLKKENQSYKQEIKN 388

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 151301150   85 kdiLKRNKNHLQKQAEKNftDEGDQLFKMGIKVLQQSKSQKQKE 128
Cdd:TIGR04523 389 ---LESQINDLESKIQNQ--EKLNQQKDEQIKKLQQEKELLEKE 427
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 443-478 1.08e-04

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 39.85  E-value: 1.08e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 151301150   443 PLAIYYLAKMYATGTGVVRSCRTAVELYKGVCELGH 478
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 407-441 1.91e-04

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 39.04  E-value: 1.91e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 151301150  407 PDAQFQLGFMYYSGSGIWKDYKLAFKYFYLASQSG 441
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 334-370 3.11e-03

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 35.61  E-value: 3.11e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 151301150   334 ANAMAFIGKMYLEGNAaVPQNNATAFKYFSMAASKGN 370
Cdd:smart00671   1 AEAQYNLGQMYEYGLG-VPKDLEKALEYYKKAAELGN 36
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 551-586 4.26e-03

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 35.23  E-value: 4.26e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 151301150   551 AFARVKIGDYHYYGYGTKKDYQTAATHYSIAANKYH 586
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 216-247 9.10e-03

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 34.46  E-value: 9.10e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 151301150   216 MSQMILGYRYLSGINVLQNCEVALSYYKKVAD 247
Cdd:smart00671   2 EAQYNLGQMYEYGLGVPKDLEKALEYYKKAAE 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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