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Conserved domains on  [gi|13384778|ref|NP_079672|]
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6-phosphogluconolactonase isoform 1 [Mus musculus]

Protein Classification

6-phosphogluconolactonase( domain architecture ID 10471859)

6-phosphogluconolactonase catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate, which is the the second step of the oxidative phase of the pentose phosphate pathway

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
13-237 2.89e-93

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


:

Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 273.73  E-value: 2.89e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13384778    13 SSPQELGASLAQLVAQRAASCLEgDRGRFALGLSGGSLVSMLARDLPAAAAPAgpaSFARWTLGFCDERLVPFDHAESTY 92
Cdd:pfam01182   1 PDAEALAQALAERLAEALEAALA-ERGRFTLALSGGSTPKPLYELLAAAPARL---DWSRVHVFWGDERCVPPDDPDSNY 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13384778    93 GLYRTHLLSKLPIPDSQVLTIN-PALPVEDAAEDYARKLRQALQGDAVPVFDLLILGVGPDGHTCSLFPDHPLLQEREKI 171
Cdd:pfam01182  77 GMAREALLSHVPIPASNVHPIPaSAADPEEAAAAYEAELRELLPDLELPVFDLVLLGMGPDGHTASLFPGSPALEETDRL 156

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 13384778   172 VAPISDSPKPPPQRVTLTLPVLNAAQSIIFVATGEGKAAVLKRILEDKEGTLPAALVQPRTGALCW 237
Cdd:pfam01182 157 VVAVTDSPKPPPERITLTLPVLNAARRVWFLVTGAGKADALRRALAGDPDPLPAALVRPGAGETVW 222
 
Name Accession Description Interval E-value
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
13-237 2.89e-93

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 273.73  E-value: 2.89e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13384778    13 SSPQELGASLAQLVAQRAASCLEgDRGRFALGLSGGSLVSMLARDLPAAAAPAgpaSFARWTLGFCDERLVPFDHAESTY 92
Cdd:pfam01182   1 PDAEALAQALAERLAEALEAALA-ERGRFTLALSGGSTPKPLYELLAAAPARL---DWSRVHVFWGDERCVPPDDPDSNY 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13384778    93 GLYRTHLLSKLPIPDSQVLTIN-PALPVEDAAEDYARKLRQALQGDAVPVFDLLILGVGPDGHTCSLFPDHPLLQEREKI 171
Cdd:pfam01182  77 GMAREALLSHVPIPASNVHPIPaSAADPEEAAAAYEAELRELLPDLELPVFDLVLLGMGPDGHTASLFPGSPALEETDRL 156

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 13384778   172 VAPISDSPKPPPQRVTLTLPVLNAAQSIIFVATGEGKAAVLKRILEDKEGTLPAALVQPRTGALCW 237
Cdd:pfam01182 157 VVAVTDSPKPPPERITLTLPVLNAARRVWFLVTGAGKADALRRALAGDPDPLPAALVRPGAGETVW 222
pgl TIGR01198
6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a ...
 11-247 2.79e-92

6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a part of a multifunctional protein with [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273494 [Multi-domain]  Cd Length: 233  Bit Score: 271.55  E-value: 2.79e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13384778    11 VFSSPQELGASLAQLVAQRAASCLEgDRGRFALGLSGGSLVSMLARDLPAAAApagpaSFARWTLGFCDERLVPFDHAES 90
Cdd:TIGR01198   1 VFSNSAELAEALAERIATKLQTALA-ERGQFSLALSGGRSPIALLEALAAQPL-----DWSRIHLFLGDERYVPLDHADS 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13384778    91 TYGLYRTHLLSKLPIPDSQVLTINPALP-VEDAAEDYARKLRQALQGDAVPVFDLLILGVGPDGHTCSLFPDHPLLQERE 169
Cdd:TIGR01198  75 NTGLAREALLDRVAIPASNIHPMPTELSdIEEAAELYEQELAAAFQPIVFPVFDLLLLGMGPDGHTASLFPHTPALQETE 154

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 13384778   170 KIVAPISDSPKPPPQRVTLTLPVLNAAQSIIFVATGEGKAAVLKRILEDKEGTLP-AALVQPRTGALCWFLDEAAARLL 247
Cdd:TIGR01198 155 RLVTVLTKSPKPPHERITLTLPAINAARKVFLLIAGEEKRNALAEALAVEAEPYPlPAAGVLHSGKTLWLLDYAAARKL 233
6PGL cd01400
6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the ...
 16-239 1.42e-89

6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard against the accumulation of the delta form of the lactone, which may be toxic through its reaction with endogenous cellular nucleophiles.


Pssm-ID: 238694 [Multi-domain]  Cd Length: 219  Bit Score: 264.04  E-value: 1.42e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13384778  16 QELGASLAQLVAQRAASCLEGdRGRFALGLSGGSLVSMLARDLPAAAAPagpaSFARWTLGFCDERLVPFDHAESTYGLY 95
Cdd:cd01400   1 EALAEALADRIAEALAAAIAK-RGRFSLALSGGSTPKPLYELLAAAPAL----DWSKVHVFLGDERCVPPDDPDSNYRLA 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13384778  96 RTHLLSKLPIPDSQVLTINPALPVEDAAEDYARKLRQALqgDAVPVFDLLILGVGPDGHTCSLFPDHP-LLQEREKIVAP 174
Cdd:cd01400  76 REALLSHVAIPAANIHPIPTELGPEDAAAAYEKELRALF--GGVPPFDLVLLGMGPDGHTASLFPGHPaLLEETDRLVVA 153

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 13384778 175 ISDSPKPPPQRVTLTLPVLNAAQSIIFVATGEGKAAVLKRILEDKEG-TLPAALVQPRTGALCWFL 239
Cdd:cd01400 154 VTDSPKPPPERITLTLPVLNNARRVVFLVTGAEKAEALKRALAGPDPeELPAARVLPRPGEVLWFL 219
PLN02360 PLN02360
probable 6-phosphogluconolactonase
 9-247 8.23e-70

probable 6-phosphogluconolactonase


Pssm-ID: 166001 [Multi-domain]  Cd Length: 268  Bit Score: 215.88  E-value: 8.23e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13384778    9 ISVFSSPQELGASLAQLVAQRAASCLEgDRGRFALGLSGGSLVSMLARdlPAAAAPAGPASFARWTLGFCDERLVPFDHA 88
Cdd:PLN02360  13 IRVHENLDELSTDLAEYIAELSEASVK-ERGVFAIALSGGSLISFMGK--LCEAPYNKTVDWAKWYIFWADERVVAKNHA 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13384778   89 ESTYGLYRTHLLSKLPIPDSQVLTINPALPVEDAAEDYARKLRQALQGDAV--------PVFDLLILGVGPDGHTCSLFP 160
Cdd:PLN02360  90 DSNYKLAKDGLLSKVPVVPSHVYSINDTVTAEEAATDYEFAIRQLVKTRTIgvsdisdcPKFDLILLGMGSDGHVASLFP 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13384778  161 DHPLLQEREKIVAPISDSPKPPPQRVTLTLPVLNAAQSIIFVATGEGKA-AVLKRILEDKEG----TLPAALVQPRTGAL 235
Cdd:PLN02360 170 NHPALEEKDDWVTFITDSPKPPPERITFTLPVINSASNVAVVATGESKAnAVHLAIDDVTEGpdapSLPARMVQPTKGKL 249

                        250
                 ....*....|..
gi 13384778  236 CWFLDEAAARLL 247
Cdd:PLN02360 250 VWFLDKPAASKL 261
NagB COG0363
6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport ...
 9-248 5.17e-66

6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440132 [Multi-domain]  Cd Length: 248  Bit Score: 205.39  E-value: 5.17e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13384778   9 ISVFSSPQELGASLAQLVAQRAASCLEgDRGRFALGLSGGS--------LVSMLARDlpaaaapagPASFARWTLGFCDE 80
Cdd:COG0363   4 VIIFPDAEELAAAAAERAAERIAEAIA-EKGRAVLGLAGGStplglyeeLARLHKEG---------GLDWSRVHVFNLDE 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13384778  81 RL-VPFDHAESTYGLYRTHLLSKLPIPDSQVLTINPALP-VEDAAEDYARKLRQAlqgdavPVFDLLILGVGPDGHTCSL 158
Cdd:COG0363  74 YVgLPPDHPQSNRRFMREALLDHVDIPPENIHIPDGEAEdPEAAAARYEALIAEA------GGIDLQLLGIGEDGHIAFN 147

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13384778 159 FPDHPLLQEREKIVAP-----------ISDSPKPPPQRVTLTLPVLNAAQSIIFVATGEGKAAVLKRILEDKEGT-LPAA 226
Cdd:COG0363 148 FPGSPFLSETDRVVTLdestrqanarfFGSIPKVPPQAITLGIPTIMKAREILLLATGENKAEAVAAALEGPVTEeVPAS 227

                       250       260
                ....*....|....*....|..
gi 13384778 227 LVQPRTGALcWFLDEAAARLLS 248
Cdd:COG0363 228 ILQGHPNVT-WFLDEAAASLLT 248
 
Name Accession Description Interval E-value
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
13-237 2.89e-93

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 273.73  E-value: 2.89e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13384778    13 SSPQELGASLAQLVAQRAASCLEgDRGRFALGLSGGSLVSMLARDLPAAAAPAgpaSFARWTLGFCDERLVPFDHAESTY 92
Cdd:pfam01182   1 PDAEALAQALAERLAEALEAALA-ERGRFTLALSGGSTPKPLYELLAAAPARL---DWSRVHVFWGDERCVPPDDPDSNY 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13384778    93 GLYRTHLLSKLPIPDSQVLTIN-PALPVEDAAEDYARKLRQALQGDAVPVFDLLILGVGPDGHTCSLFPDHPLLQEREKI 171
Cdd:pfam01182  77 GMAREALLSHVPIPASNVHPIPaSAADPEEAAAAYEAELRELLPDLELPVFDLVLLGMGPDGHTASLFPGSPALEETDRL 156

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 13384778   172 VAPISDSPKPPPQRVTLTLPVLNAAQSIIFVATGEGKAAVLKRILEDKEGTLPAALVQPRTGALCW 237
Cdd:pfam01182 157 VVAVTDSPKPPPERITLTLPVLNAARRVWFLVTGAGKADALRRALAGDPDPLPAALVRPGAGETVW 222
pgl TIGR01198
6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a ...
 11-247 2.79e-92

6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a part of a multifunctional protein with [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273494 [Multi-domain]  Cd Length: 233  Bit Score: 271.55  E-value: 2.79e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13384778    11 VFSSPQELGASLAQLVAQRAASCLEgDRGRFALGLSGGSLVSMLARDLPAAAApagpaSFARWTLGFCDERLVPFDHAES 90
Cdd:TIGR01198   1 VFSNSAELAEALAERIATKLQTALA-ERGQFSLALSGGRSPIALLEALAAQPL-----DWSRIHLFLGDERYVPLDHADS 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13384778    91 TYGLYRTHLLSKLPIPDSQVLTINPALP-VEDAAEDYARKLRQALQGDAVPVFDLLILGVGPDGHTCSLFPDHPLLQERE 169
Cdd:TIGR01198  75 NTGLAREALLDRVAIPASNIHPMPTELSdIEEAAELYEQELAAAFQPIVFPVFDLLLLGMGPDGHTASLFPHTPALQETE 154

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 13384778   170 KIVAPISDSPKPPPQRVTLTLPVLNAAQSIIFVATGEGKAAVLKRILEDKEGTLP-AALVQPRTGALCWFLDEAAARLL 247
Cdd:TIGR01198 155 RLVTVLTKSPKPPHERITLTLPAINAARKVFLLIAGEEKRNALAEALAVEAEPYPlPAAGVLHSGKTLWLLDYAAARKL 233
6PGL cd01400
6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the ...
 16-239 1.42e-89

6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard against the accumulation of the delta form of the lactone, which may be toxic through its reaction with endogenous cellular nucleophiles.


Pssm-ID: 238694 [Multi-domain]  Cd Length: 219  Bit Score: 264.04  E-value: 1.42e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13384778  16 QELGASLAQLVAQRAASCLEGdRGRFALGLSGGSLVSMLARDLPAAAAPagpaSFARWTLGFCDERLVPFDHAESTYGLY 95
Cdd:cd01400   1 EALAEALADRIAEALAAAIAK-RGRFSLALSGGSTPKPLYELLAAAPAL----DWSKVHVFLGDERCVPPDDPDSNYRLA 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13384778  96 RTHLLSKLPIPDSQVLTINPALPVEDAAEDYARKLRQALqgDAVPVFDLLILGVGPDGHTCSLFPDHP-LLQEREKIVAP 174
Cdd:cd01400  76 REALLSHVAIPAANIHPIPTELGPEDAAAAYEKELRALF--GGVPPFDLVLLGMGPDGHTASLFPGHPaLLEETDRLVVA 153

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 13384778 175 ISDSPKPPPQRVTLTLPVLNAAQSIIFVATGEGKAAVLKRILEDKEG-TLPAALVQPRTGALCWFL 239
Cdd:cd01400 154 VTDSPKPPPERITLTLPVLNNARRVVFLVTGAEKAEALKRALAGPDPeELPAARVLPRPGEVLWFL 219
PLN02360 PLN02360
probable 6-phosphogluconolactonase
 9-247 8.23e-70

probable 6-phosphogluconolactonase


Pssm-ID: 166001 [Multi-domain]  Cd Length: 268  Bit Score: 215.88  E-value: 8.23e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13384778    9 ISVFSSPQELGASLAQLVAQRAASCLEgDRGRFALGLSGGSLVSMLARdlPAAAAPAGPASFARWTLGFCDERLVPFDHA 88
Cdd:PLN02360  13 IRVHENLDELSTDLAEYIAELSEASVK-ERGVFAIALSGGSLISFMGK--LCEAPYNKTVDWAKWYIFWADERVVAKNHA 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13384778   89 ESTYGLYRTHLLSKLPIPDSQVLTINPALPVEDAAEDYARKLRQALQGDAV--------PVFDLLILGVGPDGHTCSLFP 160
Cdd:PLN02360  90 DSNYKLAKDGLLSKVPVVPSHVYSINDTVTAEEAATDYEFAIRQLVKTRTIgvsdisdcPKFDLILLGMGSDGHVASLFP 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13384778  161 DHPLLQEREKIVAPISDSPKPPPQRVTLTLPVLNAAQSIIFVATGEGKA-AVLKRILEDKEG----TLPAALVQPRTGAL 235
Cdd:PLN02360 170 NHPALEEKDDWVTFITDSPKPPPERITFTLPVINSASNVAVVATGESKAnAVHLAIDDVTEGpdapSLPARMVQPTKGKL 249

                        250
                 ....*....|..
gi 13384778  236 CWFLDEAAARLL 247
Cdd:PLN02360 250 VWFLDKPAASKL 261
NagB COG0363
6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport ...
 9-248 5.17e-66

6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440132 [Multi-domain]  Cd Length: 248  Bit Score: 205.39  E-value: 5.17e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13384778   9 ISVFSSPQELGASLAQLVAQRAASCLEgDRGRFALGLSGGS--------LVSMLARDlpaaaapagPASFARWTLGFCDE 80
Cdd:COG0363   4 VIIFPDAEELAAAAAERAAERIAEAIA-EKGRAVLGLAGGStplglyeeLARLHKEG---------GLDWSRVHVFNLDE 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13384778  81 RL-VPFDHAESTYGLYRTHLLSKLPIPDSQVLTINPALP-VEDAAEDYARKLRQAlqgdavPVFDLLILGVGPDGHTCSL 158
Cdd:COG0363  74 YVgLPPDHPQSNRRFMREALLDHVDIPPENIHIPDGEAEdPEAAAARYEALIAEA------GGIDLQLLGIGEDGHIAFN 147

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13384778 159 FPDHPLLQEREKIVAP-----------ISDSPKPPPQRVTLTLPVLNAAQSIIFVATGEGKAAVLKRILEDKEGT-LPAA 226
Cdd:COG0363 148 FPGSPFLSETDRVVTLdestrqanarfFGSIPKVPPQAITLGIPTIMKAREILLLATGENKAEAVAAALEGPVTEeVPAS 227

                       250       260
                ....*....|....*....|..
gi 13384778 227 LVQPRTGALcWFLDEAAARLLS 248
Cdd:COG0363 228 ILQGHPNVT-WFLDEAAASLLT 248
GlcN6P_deaminase cd01399
GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase ...
 20-247 1.46e-20

GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or deamination. It is the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate (GlcNAc6P). GlcN6P deaminase is a hexameric enzyme that is allosterically activated by GlcNAc6P.


Pssm-ID: 238693 [Multi-domain]  Cd Length: 232  Bit Score: 87.16  E-value: 1.46e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13384778  20 ASLAQLVAQRAASCLEgDRGRFALGLSGGS--------LVSMLARDlpaaaapagPASFARWTLGFCDERL-VPFDHAES 90
Cdd:cd01399   1 EEMSEAAAELIAELIR-EKPPAVLGLATGStplgvyeeLIELHKEG---------GLSFSNVTTFNLDEYVgLPPDHPQS 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13384778  91 TYGLYRTHLLSKLPIPDSQVLTIN-PALPVEDAAEDYARKLRQAlqGdavPVfDLLILGVGPDGHTCslF--PDHPL--- 164
Cdd:cd01399  71 YHYFMRENLFDHIDIKPENIHIPDgNAADLEAECRRYEALIAEA--G---GI-DLQLLGIGENGHIG--FnePGSSLdsr 142

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13384778 165 -----LQEREKIV-APISDSP-KPPPQRVTLTLPVLNAAQSIIFVATGEGKAAVLKRILEDK-EGTLPAALVQ--PRTga 234
Cdd:cd01399 143 trvvtLDESTRQAnARFFDGDeDVPTQAITMGIGTIMKAKEILLLATGEGKAEAVKKALEGPvTEECPASILQlhPNV-- 220

                       250
                ....*....|...
gi 13384778 235 lCWFLDEAAARLL 247
Cdd:cd01399 221 -TVILDEAAASEL 232
nagB PRK00443
glucosamine-6-phosphate deaminase; Provisional
 9-249 4.82e-15

glucosamine-6-phosphate deaminase; Provisional


Pssm-ID: 179028 [Multi-domain]  Cd Length: 261  Bit Score: 72.55  E-value: 4.82e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13384778    9 ISVFSSPQELGASLAQLVAQRAASCLEGDRGRFALGL-SGGSLVSMLarDLPAAAAPAGPASFARWTLGFCDERL-VPFD 86
Cdd:PRK00443   3 LIILKTAEEVGKWAARHIANRINAFLPTKERPFVLGLaTGSSPLETY--KALIELHKAGKVDFSRVTTFNLDEYVgLPAD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13384778   87 HAESTYGLYRTHLLSKLPIPDSQVLTIN-PALPVEDAAEDYARKLRQAlqgdaVPVfDLLILGVGPDGH------TCSLf 159
Cdd:PRK00443  81 HPESYRYFMRENFFDHVDIPPENINLLNgNAPDPEAECRRYEEKIKSA-----GGI-DLQILGIGENGHiafnepGSSF- 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13384778  160 pDHP----LLQEREKIV------APISDSPKpppQRVTLTLPVLNAAQSIIFVATGEGKAAVLKRILEDKEGTL-PAALV 228
Cdd:PRK00443 154 -ASRtrikTLTEDTRIAnsrffdGDIEQVPK---YALTVGVGTILDAKEIMLLAPGHNKAEAVKAAVEGPVNHMwPASIL 229

                        250       260
                 ....*....|....*....|...
gi 13384778  229 Q--PRTgalCWFLDEAAARLLSV 249
Cdd:PRK00443 230 QlhPKA---TLVLDEAAASELKV 249
PTZ00285 PTZ00285
glucosamine-6-phosphate isomerase; Provisional
 84-249 4.31e-10

glucosamine-6-phosphate isomerase; Provisional


Pssm-ID: 140308  Cd Length: 253  Bit Score: 58.23  E-value: 4.31e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13384778   84 PFDHAESTYGLYRTHLLSKLPIPDSQVLTINPALP-VEDAAEDYARKLRqalqgdAVPVFDLLILGVGPDGHTCSLFPDH 162
Cdd:PTZ00285  78 PRDHPQSYHYFMKENFFDHVDIKEENRHILNGTAPdLEEECRRYEEKIR------AVGGIDLFLAGIGTDGHIAFNEPGS 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13384778  163 PLLQE-------REKIVAPI----SDSPKPPPQRVTLTLPVLNAAQSIIFVATGEGKA-AVLKRILEDKEGTLPAALVQp 230
Cdd:PTZ00285 152 SLDSRtrvkslnQETIDANArffgNDISKVPTMALTVGIRTIMEAREVLLLATGASKAiAVARCVEGGVTHMCPASALQ- 230

                        170
                 ....*....|....*....
gi 13384778  231 RTGALCWFLDEAAARLLSV 249
Cdd:PTZ00285 231 MHPAAVLCLDEDATLELKV 249
PRK12358 PRK12358
glucosamine-6-phosphate deaminase;
79-248 9.31e-10

glucosamine-6-phosphate deaminase;


Pssm-ID: 183470  Cd Length: 239  Bit Score: 57.45  E-value: 9.31e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13384778   79 DErlVPFDHAES---TYGLYRTHLLSKLPIPDSQVLTINpalpVEDAAEdYARKLRQAlqGDavpvFDLLILGVGPDGHT 155
Cdd:PRK12358  66 DE--IPFRGKEGegvTITNLRNLFFTPAGIKEENIHKLT----IDNYRE-HDQKLARD--GG----LDLVVLGLGADGHF 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13384778  156 CSLFPDH----------PLLQEREKIVAPI---SDSPKPPPQRVTLTLPVLNAAQSIIFVATGEGKAAVLKRILEDK-EG 221
Cdd:PRK12358 133 CGNLPGTthfhdetvevPIQGEMVDIVAHGelgGDFSLVPDSYVTMGPKSIMAAKNLLLIVNGKGKAQILKKVLQGPvTE 212

                        170       180
                 ....*....|....*....|....*....
gi 13384778  222 TLPAALVQ--PrtgALCWFLDEAAARLLS 248
Cdd:PRK12358 213 DVPASILQlhP---NLTVILDEAAAAELA 238
PRK02122 PRK02122
glucosamine-6-phosphate deaminase-like protein; Validated
 86-247 4.08e-07

glucosamine-6-phosphate deaminase-like protein; Validated


Pssm-ID: 235005 [Multi-domain]  Cd Length: 652  Bit Score: 50.41  E-value: 4.08e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13384778   86 DHAESTYGLYRTHLLSKLPIPDSQVLTINPALPVEDAAE---DYARKLRQAlqGDavpvFDLLILGVGPDGH-------- 154
Cdd:PRK02122 106 DSLQSYHRFMKENLFDHVDIPPENIHIPDGTIPKEEIDEycrDYEEKIEAA--GG----IDFQLLGIGRTGHigfnepgs 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13384778  155 -----TCSLFPDHPllqEREKIVAPISDSPKPPPQRVTLTLPVLNAAQSIIFVATGEGKAAVLKRILEDKE-GTLPAALV 228
Cdd:PRK02122 180 grnsrTRLVTLDHI---TRRDAASDFFGEENVPRKAITMGVGTILKARRIVLLAWGEHKAPIIKRAVEGEIsDEVPASYL 256

                        170
                 ....*....|....*....
gi 13384778  229 QPRTGAlCWFLDEAAARLL 247
Cdd:PRK02122 257 QEHPNA-TFVLDLAAASEL 274
SugarP_isomerase cd00458
SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate ...
 23-173 4.63e-07

SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium, the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate. 6PGL converts 6-phosphoglucono-1,5-lactone to 6-phosphogluconate, the second step of the oxidative phase of the pentose phosphate pathway.


Pssm-ID: 238258  Cd Length: 169  Bit Score: 48.50  E-value: 4.63e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13384778  23 AQLVAQRAASCLEGDRgRFALGLSGGS--------LVSMLARdlpaaaapagpASFARWTLGFCDERLVPFDHAESTYGL 94
Cdd:cd00458   5 LKFIEDK*EKLLEEKD-DMVIGLGTGStpayfyklLGEKLKR-----------GEISDIVGFPTDERYVPLDSDQSNFRQ 72

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 13384778  95 YRTHLLSKLPIPDSQVLTINPALPVEDAAEDYARKLRqalqgDAVPVFDLLILGVGPDGHTCSLfpdhpLLQEREKIVA 173
Cdd:cd00458  73 AKLLAFEHDIIPASNVHYVDTSLPIEKACEKYEREIL-----DQVDAIDLAVDGAGYRAGTVIV-----LVDGRKKVDY 141
PRK09762 PRK09762
galactosamine-6-phosphate isomerase; Provisional
 83-228 9.51e-07

galactosamine-6-phosphate isomerase; Provisional


Pssm-ID: 182064  Cd Length: 232  Bit Score: 48.29  E-value: 9.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13384778   83 VPFDHAESTYGLYRTHLLSKLPIPDSQVLTINPAlpvedaAEDYARKLRQALQGDAVPVFDLLILGVGPDGHTCSLFPDH 162
Cdd:PRK09762  72 LPLTMPGTCETFLQQHIVQPLGLREDQLISFRSE------EINETECERVTNLIARKGGLDLCVLGLGKNGHLGLNEPGE 145

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 13384778  163 PL--------LQEREKIVAPISDSPKPPPQRVTLTLPVLNAAQSIIFVATGEGKAAVLKRILEDKEGT-LPAALV 228
Cdd:PRK09762 146 SLqpachisqLDARTQQHEMLKTAGRPVTRGITLGLKDILNAREVLLLVTGEGKQDATERFLTAKVSTaIPASFL 220
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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