|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
34-468 |
0e+00 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 533.69 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 34 ELRALLVLAGPAFLAQLMMFLISFISSVFCGHLGKLELDAVTLAIAVINVTGISVGHGLSSACDTLISQTYGSQNLKHVG 113
Cdd:cd13132 1 EAKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSFANVTGFSILLGLASALDTLCGQAFGAKNYKLVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 114 VILQRGTLILLLCCFPCWALFINTEQILLLFRQDPDVSRLTQTYVMIFIPALPAAFLYTLQVKYLLNQGIVLPQIMTGIA 193
Cdd:cd13132 81 VYLQRALVILLLCCVPISLLWLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 194 ANLVNALANYVFLYHLHLGVMGSALANTISQFALAIFLFLYILWRRLHQATWGGWSWECLQDWASFLRLAIPSMLMLCIE 273
Cdd:cd13132 161 ALLLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLLLLYIFFSKGHKATWGGFSREAFRGWGPFLKLAIPSALMLCLE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 274 WWAYEVGSFLSGIL-GMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTELFAVTFCV 352
Cdd:cd13132 241 WWAFEILVLLAGLLpGTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALILSLVIGVVVAI 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 353 LLLGCKDLVGYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVNAIGYYVIGLPIGIALMFAAK 432
Cdd:cd13132 321 LLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGAYVNLVAYYLIGLPVGLLLAFVLG 400
|
410 420 430
....*....|....*....|....*....|....*.
gi 166197685 433 LGVIGLWSGIIICTTCQTTCFLAFIARLNWKRACQQ 468
Cdd:cd13132 401 LGLKGLWIGLIAGLILQAVILLLIILRTDWDKEAEK 436
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
34-463 |
6.33e-73 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 239.32 E-value: 6.33e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 34 ELRALLVLAGPAFLAQLMMFLISFISSVFCGHLGKLELDAVTLAIAVINVTgISVGHGLSSACDTLISQTYGSQNLKHVG 113
Cdd:cd13131 1 ELRALLRLALPILIAQLAQMAMGFVDTVMAGRLGADDLAAVALGSSLWFPV-FTFGMGLLLAVTPLVAQAHGAGDRRRIR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 114 VILQRGTLILLLCCFPCWALFINTEQILLLFRQDPDVSRLTQTYVMIFIPALPAAFLYTLQVKYLLNQGIVLPQIMTGIA 193
Cdd:cd13131 80 RAVRQGLWLALLLSLPLMLLLWLAPPILPLMGQEPEVAAIARGYLLALAWGIPPALLFQVLRSFLDALGRTRPAMVITLL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 194 ANLVNALANYVFLY-HLH---LGVMGSALANTISQFALAIFLFLYILWRRL--HQATWGGWSWECLQDWASFLRLAIPSM 267
Cdd:cd13131 160 ALVLNIPLNYVLIFgKFGlpaLGGAGAGLATAIVYWLMFLALAFYIRRHKRfrRYRLFARFWRPDWARLKELLRLGLPIG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 268 LMLCIEWWAYEVGSFLSGILGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTELFA 347
Cdd:cd13131 240 LTIFFEVSLFAAVALLMGRLGTTVLAAHQIALNFASLLFMVPLGISMAATVRVGFALGAGDPADARRAGLVGLGLGVGFA 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 348 VTFCVLLLGCKDLVGYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVNAIGYYVIGLPIGIAL 427
Cdd:cd13131 320 ALTALLLLLFPEQIAGLYTNDPAVIALAASLLVFAALFQLFDGIQVVAAGALRGYKDTRVPFLLALISYWGIGLPLGYLL 399
|
410 420 430
....*....|....*....|....*....|....*.
gi 166197685 428 MFAAKLGVIGLWSGIIICTTCQTTCFLAFIARLNWK 463
Cdd:cd13131 400 AFTTGLGAFGVWIGLIIGLALAAILLLWRFRRLQRR 435
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
35-456 |
1.20e-71 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 235.81 E-value: 1.20e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 35 LRALLVLAGPAFLAQLMMFLISFISSVFCGHLGKLELDAVTLAIAVINVTgISVGHGLSSACDTLISQTYGSQNLKHVGV 114
Cdd:COG0534 7 LKLLLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFFLL-IALGIGLGVGGTALVAQALGAGDREEARR 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 115 ILQRGTLILLLCCFPCWAL-FINTEQILLLFRQDPDVSRLTQTYVMIFIPALPAAFLYTLQVKYLLNQGIVLPQIMTGIA 193
Cdd:COG0534 86 VLGQALLLALLLGLLLTLLgLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIMLI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 194 ANLVNALANYVFLYHLHLGVMGSALANTISQFALAIFLFLYILWRRLHQATWGGWSWECLQDWASFLRLAIPSMLMLCIE 273
Cdd:COG0534 166 GNVLNIVLDPLLIFGGGLGVAGAALATVISQAVSALLLLYYLFRKRSLLRLRLRDLRPDRKILKRILRIGLPAGLQQLAE 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 274 WWAYEVGSFLSGILGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTELFAVTFCVL 353
Cdd:COG0534 246 SLGFLVLNALVARLGTAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGIGLLLALL 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 354 LLGCKDLVGYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVNAIGYYVIGLPIGIALMFaAKL 433
Cdd:COG0534 326 LFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLAYLLAF-LGL 404
|
410 420
....*....|....*....|...
gi 166197685 434 GVIGLWSGIIICTTCQTTCFLAF 456
Cdd:COG0534 405 GLTGVWLALPIGEVLRALLLLLR 427
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
44-383 |
3.70e-61 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 205.56 E-value: 3.70e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 44 PAFLAQLMMFLISFISSVFCGHLGKLELDAVTLAiAVINVTGISVGHGLSSACDTLISQTYGSQNLKHVGVILQRGTLIL 123
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLG-SSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 124 LLCCFPCWALFINTEQILLLFRQ-DPDVSRLTQTYVMIFIPALPAAFLYTLQVKYLLNQGIVLPQIMTGIAANLVNALAN 202
Cdd:TIGR00797 80 LLLGLPVLLVGYFFIDPLLSLMGaDGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 203 YVFLYHLH--LGVMGSALANTISQFALAIFLFLYILWRRLHQATWGGWSWECLQDWASFLRLAIPSMLMLCIEWWAYEVG 280
Cdd:TIGR00797 160 YILIFGKFgfLGIVGAALATVISYWLMFLLLLYYIKKAKKIGLKWEGLLKPDWEVLKRLLKLGLPIAFRVILESLSFALL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 281 SFLSGILGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTELFAVTFCVLLLGCKDL 360
Cdd:TIGR00797 240 ALLVARLGSIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILILFREF 319
|
330 340
....*....|....*....|...
gi 166197685 361 VGYIFTTDRDIVALVAQVIPIYA 383
Cdd:TIGR00797 320 IARLFTNDPEVLELAAIYLIFVA 342
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
42-457 |
1.43e-52 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 184.83 E-value: 1.43e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 42 AGPAFLAQLMMFLISFISSVFCGHLGKLELDAVTLAIAVINvTGISVGHGLSSACDTLISQTYGSQNLKHVGVILQRGTL 121
Cdd:cd12082 1 AAPLLLSMLLQTLYNLVDTFFLGRLLGDALAAVGLAFPLIA-LLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 122 ILLLCCFPCWAL-FINTEQILLLFRQDPDVSRLTQTYVMIFIPALPAAFLYTLQVKYLLNQGIVLPQIMTGIAANLVNAL 200
Cdd:cd12082 80 LAILLGLLLAALlLFFSPLILSLLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNIL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 201 ANYVFLY---HLHLGVMGSALANTISQFALAIFLFLYILWRRLHQATWGGWSWECLQDWASFLRLAIPSMLMLCIEWWAY 277
Cdd:cd12082 160 LDPLLIFglgPPELGIAGAALATVISYVIGALLLLIYLRKGKKILKFKLSLLKPDLELLRRLLRIGLPSAIQNSLLSLGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 278 EVGSFL-SGILGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTELFAVTFCVLLLG 356
Cdd:cd12082 240 LIIVAIvAAFGGAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAVLGLLILL 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 357 CKDLVGYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVNAIGYYVIGLPIGIALMFAAkLGVI 436
Cdd:cd12082 320 FPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRLPLAYVLAYLG-LGLY 398
|
410 420
....*....|....*....|.
gi 166197685 437 GLWSGIIICTTCQTTCFLAFI 457
Cdd:cd12082 399 GIWLALVISLILAALVLLLFF 419
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
35-462 |
2.61e-51 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 181.96 E-value: 2.61e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 35 LRALLVLAGPAFLAQLMMFLISFISSVFCGHLGKLELDAVTLAiAVINVTGISVGHGLSSACDTLISQTYGSQNLKHVGV 114
Cdd:cd13133 4 YREILKIALPLVLSMLSQTVMGFTDRAFLGRLSEVALAASGPA-GVLYFAILMLFFGLSSGVQVFVAQYNGAGRYSRIGR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 115 ILQRGTLILLLCCFPCWALFI-NTEQILLLFRQDPDVSRLTQTYVMIFIPALPAAFLYTLQVKYLLNQGIVLPQIMTGIA 193
Cdd:cd13133 83 VLWQGLYFSLLLAPLLALLSAlAAPLLFLLLGHSPEVQALEVEYFRIRILGAPFSLLGAALRAFFSGIGRTRVVMVANLV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 194 ANLVNALANYVFLY-HL---HLGVMGSALANTISQFALAIFLFLYILWRRLHQ--ATWGGWSWEcLQDWASFLRLAIPSM 267
Cdd:cd13133 163 MVVVNIVLDYALIFgKLgfpAMGIAGAAIATVIAEAVSLLFFLLLLFRRKNRRrfGLRRAWRFD-RELLRRILRLGLPSG 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 268 LMLCIEWWAYEVGSFLSGILGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTELFA 347
Cdd:cd13133 242 LQFFLDVGAFTVFFLLIGRLGTTELAATNIVFSINSLAFLPMIGLGIAVSSLVGQALGAGRPDLAMRVTRRGLKLALAYM 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 348 VTFCVLLLGCKDLVGYIFTTDRDIVALVAQVIPIY---AVSHLFEGLACTCGGILRGTGNQKVGAIVNAIGYYVIGLPIG 424
Cdd:cd13133 322 LLLGILFLLFPELLLSIFTPGADFALIAELAVPLLrfvAAYILFDALALVFAGALRGAGDTRFVMLAELIVAWLYLLPPA 401
|
410 420 430
....*....|....*....|....*....|....*...
gi 166197685 425 IALMFaAKLGVIGLWSGIIICTTCQTTCFLAFIARLNW 462
Cdd:cd13133 402 YLLVV-LGAGLAGAWTVETVYVIVLALIFLLRFRSGKW 438
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
36-463 |
3.78e-51 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 181.56 E-value: 3.78e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 36 RALLVLAGPAFLAQLMMFLISFISSVFCGHLGKLELDAVTLAIAVINVTgISVGHGLSSACDTLISQTYGSQNLKHVGVI 115
Cdd:cd13137 1 RRIWSLAWPVILENLLQTLVGLVDVFMVGRLGAEAIAAVGLATQVLWLL-LVLNMALGTGTVALVSQSYGAGDYERARRA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 116 LQRGTLILLLCCFP-CWALFINTEQILLLFRQDPDVSRLTQTYVMIFIPALPAAFLYTLQVKYLLNQGIVLPQIMTGIAA 194
Cdd:cd13137 80 LGQSLLLALLLSLPlALLGLLFAEPLLRLLGADPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYIMIIV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 195 NLVNALANYVFLYHLH----LGVMGSALANTISQFALAIFLFLYILWRRLH-QATWGGWSWEcLQDWASFLRLAIPSMLM 269
Cdd:cd13137 160 NVLNIVLDYVLIFGLWgfpgLGVAGAALATVISRVVGALLLLFLLLRGRLPiKISFKGFRLD-RKIIKKLLRIGLPAGLE 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 270 LCIEWWAYEVGSFLSGILGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTELFAVT 349
Cdd:cd13137 239 QLLRSLGFLVLLAIVASYGTAALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEARRYGKRALRLGVLFMGL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 350 FCVLLLGCKDLVGYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVNAIGYYVIGLPIGIALMF 429
Cdd:cd13137 319 LGLLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIINLISMWLVRLPLAYLLGF 398
|
410 420 430
....*....|....*....|....*....|....
gi 166197685 430 AAKLGVIGLWSGIIICTTCQTTCFLAFIARLNWK 463
Cdd:cd13137 399 VLGLGLTGIWLAMFVDTIVRAILLLYRFRKGKWK 432
|
|
| PRK01766 |
PRK01766 |
multidrug efflux protein; Reviewed |
31-444 |
4.98e-42 |
|
multidrug efflux protein; Reviewed
Pssm-ID: 234981 [Multi-domain] Cd Length: 456 Bit Score: 156.90 E-value: 4.98e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 31 FLEELRALLVLAGPAFLAQLMMFLISFISSVFCGHLGKLELDAVTLAiAVINVTGISVGHGLSSACDTLISQTYGSQNLK 110
Cdd:PRK01766 7 YKSEARQLLALALPILLAQVAQTAMGFVDTVMAGGVSATDLAAVAIG-TSIWLPVILFGHGLLLALTPIVAQLNGAGRRE 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 111 HVGVILQRGTLILLLCCFPCWALFINTEQILLLFRQ-DPDVSRLTQTYVMIFIPALPAAFLYtlQVKYLLNQGI--VLPQ 187
Cdd:PRK01766 86 RIAHQVRQGLWLALFLSVLIMLVLYNAVPPILNMMNlEPEVADIAVGYLHALLWGIPAYLLY--QVLRSFIDGLgkTKPT 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 188 IMTGIAANLVNALANYVFLYHL----HLGVMGSALANTISQFALAIFLFLYILWRRL--HQATWGGWSWECLQDWASFLR 261
Cdd:PRK01766 164 MVIGFLGLLINIPLNYIFIYGKfgfpELGGVGCGVATAIVYWVMFLAMLIYIKRARRfrDFRLFKGLYKPDWAVIKRLLK 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 262 LAIPSMLMLCIEWWAYEVGSFLSGILGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAISLI 341
Cdd:PRK01766 244 LGLPIGLAIFFEVSLFAVVTLLVSPLGTVTVAAHQIALNFSSLLFMLPLSLAMALTIRVGFELGAGRTLDARQYAYIGLA 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 342 VTELFAVTFCVLLLGCKDLVGYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVNAIGYYVIGL 421
Cdd:PRK01766 324 VGLGMALLTAIFLVLFREQIALLYTDDPEVVALASHLLLFAALFQFSDAIQVIGSGALRGYKDTRVIFFITFIAYWVLGL 403
|
410 420
....*....|....*....|...
gi 166197685 422 PIGIALMFAAKLGVIGLWSGIII 444
Cdd:PRK01766 404 PLGYILALTDPMGPFGFWIGLII 426
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
36-464 |
3.50e-41 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 154.20 E-value: 3.50e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 36 RALLVLAGPAFLAQLMMFLISFISSVFCGHLGKLELDAVTLAIAVINVtGISVGHGLSSACDTLISQTYGSQNLKHVGVI 115
Cdd:cd13134 3 LSLFALAWPIFIELLLQMLLGTIDTFMLSRYSDNAVAAVGVANQILFL-LILIFSFISTGTSILIAQYLGAKDKKKARQI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 116 LQRGTLI-LLLCCFPCWALFINTEQILLLFRQDPDVSRLTQTYVMIFIPALpaaFLYTLQVKY---LLNQGIVLPQIMTG 191
Cdd:cd13134 82 AGVALLFnLLLGLVFSLLLLFFGAELLRLMGLPPELLALGSTYLRIVGGSL---FLQALSLTLsaiLRSHGRTKIPMYVS 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 192 IAANLVNALANYVFLY----HLHLGVMGSALANTISQFA---LAIFLFLYILWRRLHQATWGGWSWECLQDwasFLRLAI 264
Cdd:cd13134 159 LIMNILNIVGNYLLIFgwfgLPKLGVAGVAISTVISRAVglvLLFILLFRKLKIRFRLKDLRPFPKKLLKK---ILKIGL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 265 PSMLmlciEWWAYEVGSFLS----GILGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAISL 340
Cdd:cd13134 236 PSAG----EELSYNLSQTVItafiARLGTAALAARTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFDEAYKRVLKSL 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 341 IVTELFAVTFCVLLLGCKDLVGYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVNAIGYYVIG 420
Cdd:cd13134 312 KIGLLVSLAVALLLALFREPILGLFTDDPEIIALGKTLLLISILLEPGRAFNIVLIGSLRAAGDARFPVLIGIISMWGIS 391
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 166197685 421 LPIGIALMFAAKLGVIGLWSGIIICttcqtTCFLAFIARLNWKR 464
Cdd:cd13134 392 VPLAYLLGIVLGLGLLGVWIAFAAD-----EWVRGIIMLWRWRS 430
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
35-463 |
1.01e-36 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 141.44 E-value: 1.01e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 35 LRALLVLAGPAFLAQLMMFLISFISSVFCGH-LGKLELDAVTLAIAVINVTgISVGHGLSSACDTLISQTYGSQNLKHVG 113
Cdd:cd13138 2 LKTLLLFALPLLLSNLLQQLYNLVDLLIVGQfLGVAALAAVSNGSPIIFLL-TAIGMGLSMGGTILISQYIGAKDEEKAK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 114 -VILQRGTLILLLCCFPCWALFINTEQILLLFRQDPDVSRLTQTYVMIFIPALPAAFLYTLqVKYLLNqGI---VLPQIM 189
Cdd:cd13138 81 kAVGTLLVLFLILGIVLTILGLLFAPPILRLMNTPAEILELAVSYLRICFLGIPFIFGYNA-YSAILR-GLgdsKTPLYF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 190 TGIAAnLVNALANYVFLYHLHLGVMGSALANTISQFALAIFLFLYILWRRLH-QATWGGWSWEcLQDWASFLRLAIPSML 268
Cdd:cd13138 159 VIIAC-VLNIILDLLFIAVFHMGVAGAALATVIAQAISVLLALYYLRKKKLPfKLSLKDFRFD-KEILKEILKIGLPSAL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 269 MLCIewwayevgSFLSGIL--------GMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAISL 340
Cdd:cd13138 237 QQSL--------VSISFLIinsivnsyGVVASAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIERAKKGLRTGI 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 341 IVTELFAVTFCVLLLGCKDLVGYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVNAIGYYVIG 420
Cdd:cd13138 309 IISLIIGLIIILLVFFFAPQLLGLFTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMIISILRLWLVR 388
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 166197685 421 LPIGIALMFAAKLGVIGLWSGIIICTTCQTTCFLAFIARLNWK 463
Cdd:cd13138 389 IPLAYLLSRLTGLGLFGIWLAMPISNILSAIICIIYYRKGRWK 431
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
36-439 |
5.79e-33 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 130.71 E-value: 5.79e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 36 RALLVLAGPAFLAQLMMFLISFISSVFCGHL-GKLELDAVTLAIAVIN-VTGISVGHGLSSAcdTLISQTYGSQNLKHVG 113
Cdd:cd13143 4 KLFLKFALPAIIGMLVNGLYNIVDGIFVGHGvGALALAAVNLVFPIIMlLMALGLMIGVGGA--SLISRRLGAGDREKAN 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 114 VILQRG-TLILLLCCFPCWALFINTEQILLLFRQDPDVSRLTQTYVMIFIPALPAAFLYTLQVKYLLNQGIVLPQIMTGI 192
Cdd:cd13143 82 RIFSTAlLLSLILGLLLTILGLLFLDPLLRLLGASGELLPYAVDYLRIILLGAPFTILSSVLNNLLRAEGKPKLAMLGML 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 193 AANLVNALANYVFLYHLHLGVMGSALANTISQFALAIFLFLYILWRR-LHQATWGGWSWEcLQDWASFLRLAIPSMLMlc 271
Cdd:cd13143 162 IGAVLNIILDPLFIFVLGLGIAGAALATVIAQLISLLLLLLYFFRGKsLLKLSLLRFKLS-LKIIKEILALGFPSFLM-- 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 272 iewwayEVGSFLSGIL---------GMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAISLIV 342
Cdd:cd13143 239 ------QLSSSVVTIVlnltllgygGDIGVAAFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGNYDRVKQALKLALIV 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 343 TELFAVTFCVLLLGCKDLVGYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVNAIGYYVigLP 422
Cdd:cd13143 313 ALIYGLVLFLILLLFPEQIVSLFTDDPELIALAARILRIFLLAFPLAGINIVLSGYFQAIGKAKRAALLSLLRQGL--FL 390
|
410
....*....|....*..
gi 166197685 423 IGIALMFAAKLGVIGLW 439
Cdd:cd13143 391 IPLLLILPRLFGLDGIW 407
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
35-464 |
1.46e-32 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 130.00 E-value: 1.46e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 35 LRALLVLAGPAFLAQLMMFLISFISSVFCGHLGKLELDAVTLAIAVInVTGISVGHGLSSACDTLISQTYGSQNLKHVGV 114
Cdd:cd13142 10 LRTLLKLAWPIIVSNLLQVAYNLADTFWLGRLGADAVAAPSISWPLI-FLFISLGGGLTVAGTALVAQYTGAGDYDKANK 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 115 IL-QRGTLILLLCCFPCWALFINTEQILLLF-RQDPDVSRLTQTYVMIFIPALPAAFLY-TLQVkylLNQGI---VLPQI 188
Cdd:cd13142 89 VAgQTFSFVIILSLILAVLGYILSRPLLLLLiGAPEEVYPLALAYLRIIFLGLPFMFIFfVFNS---LLRGIgdtKTPMK 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 189 MTGIAAnLVNALANYVFLYHL----HLGVMGSALANTISQFALAIFLfLYILWRRLH------QATWGGWSWeclqdWAS 258
Cdd:cd13142 166 IMFGSV-LLNVILDPLLIFGIgpfpGLGVAGAALATVISRGIAAVIG-LYLLFKGRVglkislRDLKPDWEW-----LKK 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 259 FLRLAIPSMLMLCIEWWAYEVGSFLSGILGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAI 338
Cdd:cd13142 239 IFRIGLPSSIEQSARALGFTVMTALVAGFGTVVVAAYGIGNRIISLVFLPAFGLARATSTMVGQNLGAGQIDRAEEIVKK 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 339 SLIVTELFAVTFCVLLLGCKDLVGYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVNAIGYYV 418
Cdd:cd13142 319 AALLIFLILVIGGVLAFLFAEPIVRVFINDPEVIKEGADFLRIVAPSFPFFGLFQVINGAFRGSGHTLTAMIISILRLWV 398
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 166197685 419 IGLPIGIALMFAAKLGVIGLWSGIIICTTCQTTCFLAFIARLNWKR 464
Cdd:cd13142 399 IRIPLAYLLAYVLGLGVTGIWIAMAISNIVAALIALAWFKRGTWKK 444
|
|
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
36-444 |
8.86e-32 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 127.29 E-value: 8.86e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 36 RALLVLAGPAFLAQLMMFLISFISSVFCGHLGKL-ELDAVTLAIAVINVtgISVGHG-LSSACDTLISQTYGSQNLKHVG 113
Cdd:cd13136 3 REILALALPAILSNITVPLLGLVDTAVVGHLGSAaYLGAVALGTTIFNT--LFWLFGfLRMGTTGLVAQALGAGDREEAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 114 VILQRGTLILLLCcfpcwALFINTEQ------ILLLFRQDPDVSRLTQTYVMIFIPALPAAFL-YTLQVKYLLNQGIVLP 186
Cdd:cd13136 81 ALLVRALLLALAI-----GLLLILLQspllalALLLLGASAAVAALARQYLRIRILGAPAVLLnYVATGWFRGLQDTRTP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 187 QIMTgIAANLVNALANYVFLYHLHLGVMGSALANTISQFALAIfLFLYILWRRLHQATWGGWSweCLQDWASFLRLAIPS 266
Cdd:cd13136 156 LILQ-IVGNVVNIVLDPLFVFGLGWGVAGAALATVIAQYLGAL-LGLWLLRRRVRLLGKSLSR--RLPSKAALKRLFKLN 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 267 ------MLMLCIewwAYEVGSFLSGILGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAISL 340
Cdd:cd13136 232 rdifirTLALLA---AFLFFTALAARLGDVILAANQILLQFWLLSSYFLDGFAYAAEALVGRALGAGDRKAARRVARRLL 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 341 IVTELFAVTFCVLLLGCKDLVGYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGnqKVGAIVNAIgyyVIG 420
Cdd:cd13136 309 QWGLGLGVLLALLFFLGGEPIIRLFTDDPAVLALAATYLPWLALLPPIGALAFVLDGIFIGAT--DTRYLRNSM---LVS 383
|
410 420
....*....|....*....|....*.
gi 166197685 421 LPIGIALMFAAK--LGVIGLWSGIII 444
Cdd:cd13136 384 LAVFLPLLFLLVplWGNHGLWLALIL 409
|
|
| PRK00187 |
PRK00187 |
NorM family multidrug efflux MATE transporter; |
34-481 |
1.43e-28 |
|
NorM family multidrug efflux MATE transporter;
Pssm-ID: 166843 [Multi-domain] Cd Length: 464 Bit Score: 118.69 E-value: 1.43e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 34 ELRALLVLAGPAFLAQLMMFLISFISSVFCGHLGKLELDAVTLAIAVINVTGISVGhGLSSACDTLISQTYGSQNLKHVG 113
Cdd:PRK00187 8 ELKAILRLAGPLIASQLAHMLMVFTDTLMMGRLGPEALAGGGLGAASYSFVSIFCV-GVIAAVGTLVAIRHGAGDIEGAT 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 114 VILQRGTLILLLCCFPCWALFINTEQILLLFRQDPDVSRLTQTYVMIFIPALPAAFLYTLQVKYLLNQGIVLPQIMTGIA 193
Cdd:PRK00187 87 RLAQAGLWLAWLLALVAALLLWNLKPLLLLFGQAPQNVDAAMQFLHLLPFALPGYLSFMALRGFTSALGRAGPVMVISLA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 194 ANLVNALANYVFLYHL----HLGVMGSALANTISQFALAIFLFLYILWRRLHQA--TWGGWSWECLQDWASFLRLAIPSM 267
Cdd:PRK00187 167 GAVANLLLNYALIEGWfglpKLGLMGIGLVTALVSNGMALALALYIRRHPAYAAypLRKGLSRPSRAALRELWRLGLPIG 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 268 LMLCIEWWAYEVGSFLSGILGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAISL----IVT 343
Cdd:PRK00187 247 GTYAVEVGLFTFAALCMGALGSTQLAAHQIALQIVSVAFMVPVGLSYAVTMRVGQHYGAGRLLEARRAGRVGIgfgaVVM 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 344 ELFAVTFcvlLLGCKDLVGYIFTTD----RDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVNAIGYYVI 419
Cdd:PRK00187 327 LLFAGLF---WLLPEAIIGLFLDRNdpafAEIVQLAVSLLAVAAWFELFDGTQTIAMGAIRGLKDARTTFLIGLACYWLV 403
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 166197685 420 GLPIGIALMFAAKLGVIGLWSGIIICTTCQTtcfLAFIARLNWKRACQQAQVHANLKVNVAL 481
Cdd:PRK00187 404 GAPLAWLLAFTLGWGAVGVWWGLALGLACAA---VALTLAFEWKTARLLRKARASEAVALSA 462
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
44-204 |
1.29e-24 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 100.33 E-value: 1.29e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 44 PAFLAQLMMFLISFISSVFCGHLGKLELDAVTLAIAVINVTgISVGHGLSSACDTLISQTYGSQNLKHVGVILQRGTLIL 123
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLI-FMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 124 LLCCFP-CWALFINTEQILLLFRQDPDVSRLTQTYVMIFIPALPAAFLYTLQVKYLLNQGIVLPQIMTGIAANLVNALAN 202
Cdd:pfam01554 80 LLLSLPiALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLN 159
|
..
gi 166197685 203 YV 204
Cdd:pfam01554 160 YL 161
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
35-463 |
2.23e-24 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 106.07 E-value: 2.23e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 35 LRALLVLAGPAFLAQLMMFLISFISSVFCGHLGKLELDAV---------TLAIAVINVTGISVGhglssacdtlISQTYG 105
Cdd:cd13140 4 LKTLLRLALPIMGTSFIQMAYNLTDMFWVGRLGSDAVAAVgtagffvwlAYALALLSKIGAQVK----------VSQSIG 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 106 SQNLKHVGVILQRGTLI-LLLCCFPCWALFINTEQILLLFR-QDPDVSRLTQTYVMIFIPALPAAFLYTLQVKYLLNQG- 182
Cdd:cd13140 74 AKDEKEARKYARNALQLnLLLGILYGLLLLLFAKPLIGFFNlGDAEVISLAITYLRIVALGLIFSFLNPVFTGIFNALGd 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 183 IVLPQIMTGIAaNLVNALANYVFLYHL----HLGVMGSALANTISQfALAIFLFLYILwRRLHQATWGGWSWECL--QDW 256
Cdd:cd13140 154 SKTPFIINAIG-LVLNIILDPLLIFGFgpfpALGVAGAALATVLAQ-AIVFLLFLYAL-KKKKGLFLKIRILKRPdrKYI 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 257 ASFLRLAIP----SMLMLCIEWWayeVGSFLSGiLGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQA 332
Cdd:cd13140 231 KEILKLGLPvalqSILFALISMI---LARIIAS-FGPVAIAAQKVGSQIESISWMTAEGFSTALAAFVGQNYGAGKYDRI 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 333 KKSSAISLIVTELFAVTFCVLLLGCKDLVGYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVn 412
Cdd:cd13140 307 RKGYKTALKIASAIGLFATLLLFFFGEPLFSLFIPDPETIAIGVDYLRILGFSQLFMCLEITTTGAFNGLGRTKPPAII- 385
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 166197685 413 AIGYYVIGLPIGIALMFAAkLGVIGLWSGIIICTTCQTTCFLAFIARLNWK 463
Cdd:cd13140 386 SIVFNGLRIPLALLLSPTG-LGLNGIWWAISISSILKGIILTIWFLLYKKK 435
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
265-424 |
6.15e-24 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 98.41 E-value: 6.15e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 265 PSMLMLCIEWWAYEVGSFLSGILGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTE 344
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 345 LFAVTFCVLLLGCKDLVGYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVNAIGyYVIGLPIG 424
Cdd:pfam01554 81 LLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIIS-LLLNIPLN 159
|
|
| MATE_like_4 |
cd13144 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
35-439 |
1.44e-20 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240549 [Multi-domain] Cd Length: 434 Bit Score: 94.22 E-value: 1.44e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 35 LRALLVLAGPAFLAQLMMFLISFISSVFCGHLGKLELDAVTLAIAVINVTgISVGHGLSSACDTLISQTYGSQNLKHVGV 114
Cdd:cd13144 7 LRLLLTMSIPAMISMLFQALYNIVDSIFVARLGENALTAVSLAFPIQNLM-IAVAVGTGVGVNALLSRSLGEKDQKEANK 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 115 ILQRG-TLILLLCCFPCWALFINTEQILLLFRQDPDVSRLTQTYVMIFIPALPAAFLYTLQVKYLLNQGIVLPQIMTGIA 193
Cdd:cd13144 86 AANNGlLLALLSYLLFLLLGLFGVKPFFRLFTDDPEILEYGYAYLSWCVIFSFGMFFQILCEKVLQSTGNTITPMIAQLI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 194 ANLVNALANYVFLYHLH----LGVMGSALANTISQFALAIFLFLYILWR--------RLHQATWggwsweclQDWASFLR 261
Cdd:cd13144 166 GAIINIILDPILIFGLFgfpaMGIAGAAIATVIGQILAMFLAFFFLLRKnkdvqpdlRLFRPSL--------RIIKEIYA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 262 LAIPSMLMLCIewwayevGSFLSGILGMVELG-------AQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKK 334
Cdd:cd13144 238 VGLPSIIMQAI-------SSVMVFGLNKILAGfgptavaVFGIYFKLQSFVFMPVFGLNNGLIPIVAYNYGAGNKDRIRE 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 335 SSAISLIVTELFAVTFCVLLLGCKDLVGYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVNAI 414
Cdd:cd13144 311 AIKYAILIAVVIMLAGGLLFQLFPDQLLGLFNASEEMLAIGVPALRIISLSFLFAALSIILSGLFQALGRGVYSLIISVA 390
|
410 420
....*....|....*....|....*
gi 166197685 415 GYYVIGLPigIALMFAAKLGVIGLW 439
Cdd:cd13144 391 RQLVVLLP--LAWLLAKMFGLNGVW 413
|
|
| MATE_like_14 |
cd13139 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
36-464 |
2.07e-20 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240544 [Multi-domain] Cd Length: 448 Bit Score: 94.22 E-value: 2.07e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 36 RALLVLAGPAFLAQLMMFLISFISSVFCGHLGKLELDAVTLAIAVINVTgISVGHGLSSACDTLISQTYGSQNLKHVGVI 115
Cdd:cd13139 14 RAIFLLAIPMVLEMVMESLFAVVDLYFVSRLGALAIATVGLTESVLTIV-YSIAIGLSMAATALVARRIGEKDPEGAGFA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 116 LQRGTLILLLCCFPCWAL-FINTEQILLLFRQDPDVSRLTQTYVMIFIPALPAAFLYtlqvkyLLNQGIVLPQIMTGIA- 193
Cdd:cd13139 93 AVQAILLGVALSLILSILgYFFAEDILSLMGASPAVIAEGYGYTRIMFGGNGFIMLL------FLINGIFRGAGDAAIAm 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 194 -----ANLVNALANYVFLYHL----HLGVMGSALANTISQFALAIFLFLYILW-------RRLHQAtwggWSWECLQdwa 257
Cdd:cd13139 167 rslwlANGLNIILDPLFIFGLgpipAMGVTGAAIATTIGRSIGVLYQLYHLFKgkgriqiRRRHLK----LDWAIIK--- 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 258 SFLRLAIPSMLMLCIEwwayeVGSFLSGILGMVELGAQSIT-YELAIIVYM---IPS-GFSVAANVRVGNALGAGNIDQA 332
Cdd:cd13139 240 KIIKIAVGGILQFLIA-----SSSWIFLVRIIAEFGSTALAgYTIAIRIIMfalLPAwGLSNAAATLVGQNLGAGQPDRA 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 333 KKSsaisLIVTELFAVTFC-----VLLLGCKDLVGyIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKV 407
Cdd:cd13139 315 EKS----VWRAGKYNMVFLgivslVFFLFAEPLVS-FFTTDPEVIAIAVEALRIISLGYIFYGYGMVLSQAFNGAGDTKT 389
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 166197685 408 GAIVNAIGYYVIGLPIGIALMFAAKLGVIGLWSGIIICTTCQTTCFLAFIARLNWKR 464
Cdd:cd13139 390 PTLINLVGFWLFQIPLAYLLARHLNLGPKGVFIAIPIAETVLAIAAIILFRRGKWKT 446
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
38-444 |
2.79e-18 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 87.35 E-value: 2.79e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 38 LLVLAGPAFLAQLMMFLISFISSVFCGHLGKLELDAVTLAIAVINvTGISVGHGLSSACDTLISQTYGSQNLKHVGVILQ 117
Cdd:cd13135 3 INHIAIPLILQNLVSQLQMLVDRAFLGRISIRYYSAVGNVTTPFN-TITGFLGSISIGFTILGSQSVGAKDIKRINDYAI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 118 ---RGTLILLLCCFPCWalFINTEQILLLFRQDPDVSRLTQTYVMIFIPALP-AAFLYTLQVkYLLNQGIVLPQIMTGIA 193
Cdd:cd13135 82 ssiVYNSIIGVILFLLW--LFGARIIFVLFGVDGQILGYSINYVRIFSIYLLlLGILFTFSS-ILQGIGETKPIMYGGII 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 194 ANLVNALANYVFLY-HL---HLGVMGSALANTISQFALAIFLFLYIL-WRRLHQATWGGWS-WECLQDWASFLRLAIPSM 267
Cdd:cd13135 159 KNLLNVILDYVLIFgNFgfpRLGIIGAAIATTIANVLNLIILVYLCRkIKKLTFKLSNTKVlKANIRPYKFTIKLGLPLG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 268 LMLcIEWWAYE--VGSFLSGIlGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTEL 345
Cdd:cd13135 239 GEE-FLWNIGNlaVIRILNRI-GELALGIYTLVFGIENIVLMPMYGYSSAALTLVGESIGKKDLKEALRIGNICLGLGLL 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 346 FAVTFCVLLLGCKDLVGYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVNAIGyYVIGLPIGI 425
Cdd:cd13135 317 IYIAAAIVFLAFPYKILSLFTNDPELINYSIPYLIFIIIILFFKSINIVYGFAIRAIGDTKWMLYTQIIG-TIIVVSVAL 395
|
410
....*....|....*....
gi 166197685 426 ALMFAAKLGVIGLWSGIII 444
Cdd:cd13135 396 LLIFVFKLGLAGVYITLFI 414
|
|
| MATE_like_2 |
cd13149 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
35-444 |
1.23e-16 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240554 [Multi-domain] Cd Length: 434 Bit Score: 82.35 E-value: 1.23e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 35 LRALLVLAGPAFLAQLMMFLISFISSVFCGHLGKLELDAVTLAIAVINVTGiSVGHGLSSACDTLISQTYGSQNLKHV-- 112
Cdd:cd13149 8 PRHLIKLTLPMIFGILAMLIFNLTDTFFVGKLGTKELAAISFTFPVVLFLN-SLTIGLGIGASAVISRAIGAGDRNKAkr 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 113 ----GVILqrgTLILLLCCFPCWALFIntEQILLLFRQDPDVSRLTQTYVMIFIPALPAAFLYTLQVKYLLNQG-IVLPQ 187
Cdd:cd13149 87 latdSLIL---SLLLSVIVSLLGLFTI--PPLFSLLGASGEILPLIVEYMAIWYLGLVFLVLPMVGNAIIRATGdTKRPS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 188 IMTGIAAnLVNALANYVFLYHL----HLGVMGSALANTISQFALAIFLfLYILWRRLHQATWGGWSW-ECLQDWASFLRL 262
Cdd:cd13149 162 LVMLGAA-LVNVILDPILIFGFgpipGMGIAGAAIATVISRALGLGAA-LYFLHYHHRLIDFSEPSLkALFRSWKDILSI 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 263 AIPSMLMLCIEWWAYEVGSFLSGILGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAISLIV 342
Cdd:cd13149 240 GIPAALSNILTPLSAAFITALVATYGPAAVAAFGVATRIESFAFIIVMALSSALGPFVGQNWGAGQYERVQEGLKISLKF 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 343 TELF-AVTFCVLLLGCKDLVGyIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVNAIGYYVIGL 421
Cdd:cd13149 320 SLIYgAILGIVLALFAGWLAS-LFSAEPEVIELITLYLLIVPIGYGGLGILIITSASFNALGKPLYSLGLNLIRVFLLYI 398
|
410 420
....*....|....*....|...
gi 166197685 422 PigIALMFAAKLGVIGLWSGIII 444
Cdd:cd13149 399 P--LAYVGSHLLGFAGVFIGALA 419
|
|
| MATE_like_6 |
cd13146 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
38-460 |
6.55e-14 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240551 [Multi-domain] Cd Length: 433 Bit Score: 73.97 E-value: 6.55e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 38 LLVLAGPAFLAQLMMFLISFISSVFCGHLGKlELDAVTLAIAVINVTG---ISVGHGLSSACDTLISQTYGSQNLKHVGV 114
Cdd:cd13146 10 LIRLALPILIGQLFQLLYNITDTIWISMIDP-SDPALVGGIGLVFPLGmifLALGNGIQVGVSSLLARAIGAQRAKELDQ 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 115 ILQRGTLILLLCCFPCWAL-FINTEQILLLFRQDPDVSRLTQTYVMIFIPALPAAFLYTLQVKYLLNQGIVLPQIMTGIA 193
Cdd:cd13146 89 AADSGLALALLAATVIVVLgYIFAEPLLQLLGAKGLLLEYALEYFYYSLPGVPFIMLIGVLMGVLQGEGRTKYMMMAMLI 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 194 ANLVNALANYVFLYHLHLGVMGSALANTISQFALAIFLFLYILWR----RLHQATWGGwSWECLqdwASFLRLAIPSMLM 269
Cdd:cd13146 169 GTVVNIVLDPILIFVFDMGVKGAALATVLAQAISLLYLLYVFLIGksnvTIHIKLSNI-SSSVI---VEILRVGLPQMLL 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 270 LCIEWWAYEVGSFLSGILGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTELFAVT 349
Cdd:cd13146 245 QLISSISFLIYNRIIIDIDPVAMTAFTLVGRLDQFILIPIFAISSALLTIAGQNWGRGNYDRMLQILMTAVILGIVVVLV 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 350 FCVLLLGCKDLVGYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVNAIGYYVIGLPIGIALMF 429
Cdd:cd13146 325 LVLGYVLVAPWLFSLFTTVPEVVAYAVLQVRTMALALPFVAISILVTEFFQAIGKAWPSLLLTLIRHVFLSVPVVYLLAY 404
|
410 420 430
....*....|....*....|....*....|.
gi 166197685 430 AAKLGVIGLWSGIIICTTcqTTCFLAFIARL 460
Cdd:cd13146 405 VFGKGITGVYFGIVSANF--FTALLAMFWGL 433
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
32-234 |
8.56e-14 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 73.64 E-value: 8.56e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 32 LEELRALLVLAGPAFLAQLMMFLISFISSVFCGHLGKLELDAVTLAIAVINVTgISVGHGLSSACDTLISQTYGSQNLKH 111
Cdd:COG0534 225 RKILKRILRIGLPAGLQQLAESLGFLVLNALVARLGTAAVAAYGIALRIESLA-FMPALGLGQAAQPLVGQNLGAGDYDR 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 112 VGVILQRGTLILLLCCFPCWALF-INTEQILLLFRQDPDVSRLTQTYVMIFIPALPAAFLYTLQVKYLLNQGIVLPQIMT 190
Cdd:COG0534 304 ARRAARLALLLALGIGLLLALLLfLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMII 383
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 166197685 191 GIAANLVNALANYVFLYHLHLGVMGSALANTISQFALAIFLFLY 234
Cdd:COG0534 384 SLLRLWLVRLPLAYLLAFLGLGLTGVWLALPIGEVLRALLLLLR 427
|
|
| MATE_like_13 |
cd13141 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
38-459 |
1.56e-12 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240546 [Multi-domain] Cd Length: 443 Bit Score: 69.65 E-value: 1.56e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 38 LLVLAGPAFLAQLMMFLISFISSVFCGHLGKLELDAVTLAIAVINVTgISVGHGLSSACDTLISQTYGSQNLKHVGVILQ 117
Cdd:cd13141 13 IISMALPIAIGMIIQTLYFLVDLYFVGQLGDAALAGVSLAGNVMFFV-MALTQVLNVGTAALVSHAVGRKDQGEANAVFN 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 118 RGTLILLLCCFPCWALFINTEQILLLF-RQDPDVSRLTQTYVMIFIPALPAAFLYTLQVKYLLNQGIVLPQIMTGIAANL 196
Cdd:cd13141 92 QSLLLAAVLGLVVLVLGYLFGRLYLETlAADAATVEAATTYLYWFIPSLALQFILTVLGAALRGTGIVKPFMVIQILAVL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 197 VNALANYVFLY----HLHLGVMGSALANTISQFALAIFLFLYILW-RRLHQATWGGWSWEcLQDWASFLRLAIPS----M 267
Cdd:cd13141 172 LNIILAPILITgwgtGRALGVAGAGLASSISVAIAVVLLLYYFLRlEKYLRLDLALWRPD-LPTWKRLLKIGLPSggefL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 268 LMLC----IEWWAYEVGS-----FLSG--ILGMVELGAQSITYELAIIVymipsgfsvaanvrvGNALGAGNIDQAKKSS 336
Cdd:cd13141 251 LTFVymavIYWALRPFGAaaqagFGIGsrIMQSLFLPAMAIAFAAPAIA---------------GQNFGAGNYDRVRETF 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 337 AISLIVTELFAVTFCVLLLGCKDLVGYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVNAIGY 416
Cdd:cd13141 316 RITAILTTALMLVLTLLCQLVPELLVTPFSDDAAVIAVAATFLRYVSWNFVAAGLVFTCSGMFQALGNTWPSLLSSASRL 395
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 166197685 417 YVIGLPIgIALMFAAKLGVIGLWSGIIICTTCQTTCFLAFIAR 459
Cdd:cd13141 396 LTFALPV-IWLSAQPDFRIEQIWYLSVATTILQAALSLLLLRR 437
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
20-308 |
2.10e-09 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 60.16 E-value: 2.10e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 20 RRGLRCLLLPGFL-EELRALLVLAGPAFLAQLMMFLISFISSVFCGHLGkleldavTLAIAVIN-----------VTGIS 87
Cdd:COG0728 205 RLGLRLRPRFDLRdPGVRRVLKLMLPALLGVSVSQINLLVDTILASFLP-------EGSVSALYyadrlyqlplgLFGVA 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 88 VGhglsSACDTLISQTYGSQNLKHVGVILQRGTLILLLCCFPCWALFI--NTEQILLLF---RQDPDVSRLTQTYVMIFI 162
Cdd:COG0728 278 IG----TALLPRLSRAAAAGDLEEFRRTLSRGLRLVLLLTLPAAVGLIvlAEPIVRLLFergAFTAEDTALTALALAAYA 353
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 163 PALPAAFLYTLQVKYLLNQGIVLPQIMTGIAANLVNALANYVFLYHLhlGVMGSALANTISQFALAIFLFlYILWRRLHQ 242
Cdd:COG0728 354 LGLPAFALVKVLARAFYARQDTRTPVRIAVIAVVVNIVLNLLLVPPL--GHAGLALATSLSALVNALLLL-VLLRRRLGG 430
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 166197685 243 ATWGGWsweclqdWASFLRLAIPSMLMLCIEWWAYEVGSFLSGILGMVELGAQSITYELAIIVYMI 308
Cdd:COG0728 431 LPLRGI-------LRTLLKLLLASLVMGAVLWLLLRLLGDWLGGGLLGRLLALALLILVGAAVYFA 489
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
20-236 |
3.14e-08 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 56.18 E-value: 3.14e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 20 RRGLRCLLLPGFLEELRALLVLAGPAFLAQLMM-FLISFISSVFCGHLGKLELDAVTLAIAVINVTGISVGhGLSSACDT 98
Cdd:cd12082 203 ILKFKLSLLKPDLELLRRLLRIGLPSAIQNSLLsLGLLIIVAIVAAFGGAAALAAYTVAFRIASLAFMPAL-GLAQAALP 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 99 LISQTYGSQNLKHVGVILQRGTLI-LLLCCFPCWALFINTEQILLLFRQDPDVSRLTQTYVMIFIPALPA-AFLYTLQvK 176
Cdd:cd12082 282 VVGQNLGAGNFDRARRITWVALLIgLLIGAVLGLLILLFPEPILSLFTNDPEFLELAVSYLRILAIYYLFvGIGYVLQ-A 360
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 177 YLLNQGIVLPQIMTGIAANLVNALANYVFLYHLHLGVMGSALANTISQFALAIFLFLYIL 236
Cdd:cd12082 361 GFQAAGRTLKSLIVSLLSYWVVRLPLAYVLAYLGLGLYGIWLALVISLILAALVLLLFFR 420
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
23-236 |
6.31e-07 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 51.74 E-value: 6.31e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 23 LRCLLLPGFLEELRALLVLAGPAFLAQLMM-FLISFISSVFCGHLGKLELDAVTLAIAVINVTgISVGHGLSSACDTLIS 101
Cdd:cd13143 213 LSLLRFKLSLKIIKEILALGFPSFLMQLSSsVVTIVLNLTLLGYGGDIGVAAFGIVTRILTFL-FLPLIGLSQGLQPIIG 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 102 QTYGSQNLKHVGVILQRGTLILLLCCFPCWA-LFINTEQILLLFRQDPDVSRLTQTYVMIFIPALP-AAFLYTLQVkYLL 179
Cdd:cd13143 292 YNYGAGNYDRVKQALKLALIVALIYGLVLFLiLLLFPEQIVSLFTDDPELIALAARILRIFLLAFPlAGINIVLSG-YFQ 370
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 166197685 180 NQGIVLPQIMTGIAANLVnALANYVFLYHLHLGVMGSALANTISQFALAIFLFLYIL 236
Cdd:cd13143 371 AIGKAKRAALLSLLRQGL-FLIPLLLILPRLFGLDGIWLAFPLAEILTLLLALILLK 426
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
86-459 |
1.06e-06 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 51.06 E-value: 1.06e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 86 ISVGHGLSSACDTLISQTYGSQNLKHVGVILQRG-TLILLLCCFPCWALFINTEQILLLFRQDPDVSRLTQTYvmiFIPA 164
Cdd:cd13145 58 IAIGVGIGTGTTALIGNALGAGDRRKARRYAAQGlSFGIILAILLTVIGLFAAPPLFRLLGAEGDYLDLALEY---MDVI 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 165 LPAAFLYTLQvkYLLNqGIVLPQ---------IMTGIAANLV-NALANYVFLYHLHLGVMGSALANTISQFALAIFLFLY 234
Cdd:cd13145 135 FAGSIFFLLN--FGLN-GILNAQgdtksyrnfLIIGFFLNIIlDPLFIFGGGGIPAMGVSGIALATIISQFIGMFYLLYK 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 235 ILWRRLHQATWGGWSWECLQDWASFLRLAIPSML-MLCIEWWAYEVGSFLSGiLGMVELGAQSITYELAIIVYMIPSGFS 313
Cdd:cd13145 212 VRKSGIISGCRLRDFIPRLDVYKEILKQGFPASLnMMTIGLGIFVITYFVGQ-FGDEAVAAYGIALRIEQILLLPTIGLN 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 314 VAANVRVGNALGAGNIDQAKKSSAISLIVTELFAVTFCVLLLGCKDLVGYIFTTDRDIVALVAQ-------VIPIYAVsh 386
Cdd:cd13145 291 TAVLSIAGQNFGAKKYDRVRETYKKALKYGFVIMVVATVFLLFFAEPLMSLFTNDPAVIAIGAGylridalIFYAYVV-- 368
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 166197685 387 LFeglacTCGGILRGTGNQKVGAIVNAIGYYVIGLPIGIALMFAAKLGVIGLWSGIIICTTCQTTCFLAFIAR 459
Cdd:cd13145 369 LF-----ISVSVLQGLKRPIFALWIGLYRQLVGPALVFWLLVNVLGLGVTGIWWGIFTIVWSAAIIALLYTRR 436
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
35-245 |
1.50e-06 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 50.59 E-value: 1.50e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 35 LRALLVLAGPAFLAQLMMFLISFISSVFCGHLGKLELDAVTLAIAVINVTgISVGHGLSSACDTLISQTYGSQNLKHVGV 114
Cdd:cd13137 225 IKKLLRIGLPAGLEQLLRSLGFLVLLAIVASYGTAALAAYQIGLRIESLA-FMPGFGFSMAASTLVGQNLGAGDPDEARR 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 115 ILQRGTLI-LLLCCFPCWALFINTEQILLLFRQDPDVSRLTQTYVMIFIPALPaaFLYTlqvkyllnqGIVLPQIMTGIA 193
Cdd:cd13137 304 YGKRALRLgVLFMGLLGLLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQP--FLAI---------SFVLSGALRGAG 372
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 166197685 194 ANLVNALAN------------YVFLYHLHLGVMGSALANTISQFALAIflflyILWRRLHQATW 245
Cdd:cd13137 373 DTRPPLIINlismwlvrlplaYLLGFVLGLGLTGIWLAMFVDTIVRAI-----LLLYRFRKGKW 431
|
|
| MATE_MJ0709_like |
cd13147 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, ... |
36-457 |
1.53e-06 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, similar to Methanocaldococcus jannaschii MJ0709; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240552 [Multi-domain] Cd Length: 441 Bit Score: 50.62 E-value: 1.53e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 36 RALLVLAGPAFLAQLMMFLISFISSVFCGHLGKLELDAVTLAIAVINVTgISVGHGLSSACDTLISQTYGSQNLKHVGVI 115
Cdd:cd13147 9 KAIIKLSIPMIIAMLLQTLYNLVDAIWVAGLGADALAAIGFVFPLFMII-IGLGNGLGAGASSAISRRIGAKDKEGADNA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 116 LQRGTLI-LLLCCFPCWALFINTEQILLLFrQDPDVSRLTQTYVMIFIpalpaAFLYTLqvkyllnqgiVLPQIMTGI-- 192
Cdd:cd13147 88 AVHSILLgLIISIILTIVLLPFLEPILVLM-GAGEVLDLAVDYGRIIF-----LGSIFL----------IFNNVAYGIlr 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 193 ---------AANLVNALANYV----FLYHLHLGVMGSALANTISQFALAIFLFLYILWRR-------LHQATwggWSWEC 252
Cdd:cd13147 152 gegdtkramYAMVAGSILNIIldpiFIYTLGLGIAGAAWATVISMLISSLVLLYWFFVKKdtyvslsLKNFK---FDKKI 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 253 LQDwasFLRLAIPSMLMLCIewWAYeVGSFLSGILGMVelgaqSITYelAIIVY----------MIPS-GFSVAANVRVG 321
Cdd:cd13147 229 VKD---ILKVGIPASLEQLI--MSV-LMIILNLILVIV-----AGTD--GVAVYtagwrivsfaIIPLiGIATAVTSVTG 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 322 NALGAGNIDQAKKSSAISLIVTELFAVTFCVLLLGCKDLVGYIFT---TDRDIVALVAQVIPIYAVSHLFEGLACTCGGI 398
Cdd:cd13147 296 AAYGARNYEKLKTAYNYSIKLGLIIELIIAILIFIFAPQIAYLFTyseESAHLAPEIVAFLRIMCLFLPFVPFGMMSSSM 375
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 166197685 399 LRGTGNQKVGAIVNAIgyYVIGLPIGIALMFAA--KLGVIGLWSGIIICTTCqtTCFLAFI 457
Cdd:cd13147 376 FQGIGKGLTSLIITIL--RELIFQVLFAYLFAIvlGLGLFGVWWGIVLGNAI--GSIVGYL 432
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
19-238 |
1.71e-05 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 47.59 E-value: 1.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 19 ERRGLRCLLLPgfLEELRALLVLAGPAFLAQLMMFLISFISSVFCGHLGKLELDAVTLAIAVINVTGISVgHGLSSACDT 98
Cdd:cd13145 219 SGCRLRDFIPR--LDVYKEILKQGFPASLNMMTIGLGIFVITYFVGQFGDEAVAAYGIALRIEQILLLPT-IGLNTAVLS 295
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 99 LISQTYGSQNLKHVGVILQRGTLI-LLLCCFPCWALFINTEQILLLFRQDPDVSRLTQTYVMIFIPALPAAFLYTLQVKY 177
Cdd:cd13145 296 IAGQNFGAKKYDRVRETYKKALKYgFVIMVVATVFLLFFAEPLMSLFTNDPAVIAIGAGYLRIDALIFYAYVVLFISVSV 375
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 166197685 178 LlnQGIVLP--QIMTGIAANLVN-ALANYVFLYHLHLGVMGSALANTISQFALAIFLFLYILWR 238
Cdd:cd13145 376 L--QGLKRPifALWIGLYRQLVGpALVFWLLVNVLGLGVTGIWWGIFTIVWSAAIIALLYTRRV 437
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
46-437 |
1.86e-05 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 47.15 E-value: 1.86e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 46 FLAQLMMFLISFISSVFCG-HLGKLELDAVTLAIAVINVTGISVGHGLSSACDTLISQTYGSQNLKHVGVILQRGTLILL 124
Cdd:cd13128 9 FVGNIISKLLGFLVRVYLArYLGPEGFGILSLALAFVGLFSIFADLGLPTALVREIARYRKEKIREIISTSLVLKLILGI 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 125 LCcFPCWALFINteqilLLFRQDPdvsrLTQTYVMIFIPALP-AAFLYTLQVKYLLNQGIVLPQIMTGIAANLVNALAny 203
Cdd:cd13128 89 LA-LLLLFLFAF-----LIAFYDP----ELVLLLYILALSLPfSALNSLFRGIFQGFEKMKYIVIARIIESVLSLILA-- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 204 VFLYHLHLGVMGSALANTISQFALAIFLFlYILWRRLHQATWGGWSWEClqdWASFLRLAIPSMLMLCIEWWAYEVGSF- 282
Cdd:cd13128 157 LILVLLGGGLIGFALAYLIASVLSAILLL-YIYRKKILLPKFFSFDLKL---AKELLRFSIPLALSGIFSLIYTRIDTIm 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 283 LSGILGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALgAGNIDQAKKSSAISLIVTELFAVTFCVLL-LGCKDLV 361
Cdd:cd13128 233 LGYFLGDAAVGIYNAAYRIAELLLFIPSAISTALFPRISELY-KNDKDELKKLLKKSFKYLFLISLPIAIGLfLFAEPII 311
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 166197685 362 GYIFTTDrdiVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQKVGAIVNAIGyyvIGLPIGIALMFAAKLGVIG 437
Cdd:cd13128 312 TLLFGEE---YLPAALVLQILAWGFLFIFLNGIFGSILQAIGKQKLTLKILLIG---ALLNVILNLLLIPKYGIIG 381
|
|
| vmrA |
PRK09575 |
MATE family efflux transporter; |
44-439 |
3.83e-05 |
|
MATE family efflux transporter;
Pssm-ID: 236576 [Multi-domain] Cd Length: 453 Bit Score: 46.14 E-value: 3.83e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 44 PAFLAQLMMFLISFISSVFCGH-LGKLELDAVTLAIAVINVT---GISVGHGLSSacdtLISQTYGSQNLKHVGVILQRG 119
Cdd:PRK09575 20 PSIAAMLVNGLYQIVDGIFIGHyVGAEGLAGINMAWPVIGIIlgiGLMVGMGTGS----LLSIKRGEGDLEKAKRILTTG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 120 -TLILLLCCFPCWALFINTEQILLLFRQDPDVSRLTQTYVMIFIPALPAAFLYTLQVKYLLNQGIvlPQIMTG--IAANL 196
Cdd:PRK09575 96 lLLLLLLGPIVSVILFLFADDFLRAQGAEGRTLELALQYIQVLIWGCLFTLGAIALPFLLRNDES--PNLATGlmVIGAL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 197 VNALANYVFLYHLHLGVMGSALANTISQFALAIFLFLYILWRRlhqaTWGGWSWECLQDWASFLR----LAIPSMLMlci 272
Cdd:PRK09575 174 INIVLDYLFIGWLDWGLTGAAIATALAQLVVTVLGLGYFFSSR----ANIRLTLKELRFNWSLAPkivlLGSSSFFM--- 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 273 ewwaYEVGSF---LSGILGM-----VELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTE 344
Cdd:PRK09575 247 ----YLYGSFvvaLHNRLFMeygsaLTVGAYAIVGYLMVLYYLVAEGIAEGMQPPVSYYFGARQYDNIKKLLKLAMKVTV 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 345 LFAVTFCVLL-LGCKDLVGYIFTTDRDIVALVAQVIPIyavsHLF----EGLACTCGGILRGTgNQKVGAIVNAIGYYVI 419
Cdd:PRK09575 323 LAGIAWVLLLnLFPETMIALFNSGDSELIAETIVGIRL----HLFamflDGFLVLASAYFMAV-NQGGKALFISIGNMLI 397
|
410 420
....*....|....*....|.
gi 166197685 420 GLPIgiaLMFAAK-LGVIGLW 439
Cdd:PRK09575 398 QLPF---LFILPKwLGVDGVW 415
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
120-438 |
7.70e-05 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 45.14 E-value: 7.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 120 TLILLLCCFPCWALfinTEQILLLF--RQDPDVSRLTQTYVMIFIPALPAAFLYTLQVKYLLNQGIVLPQIMTGIAANLV 197
Cdd:cd13123 82 LLVLLLLTLLGILF---APLLVKLLapGFSGDKFELAVALTRIMFPYLLFISLSALLGGILNAHGRFFAPALAPVLLNLV 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 198 NALANYVFLYHLHLGVMGSALANTISQFALAIFLFLYiLWRRlhqatwgGWSWECLQDWAS-----FLRLAIPSMLMLCI 272
Cdd:cd13123 159 IIAGLLLLAPLFDLGIYALAWGVLLGGVLQLLVQLPA-LRRL-------GFRFRPRLDFRDpgvrrVLKLMLPALLGVSV 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 273 ewwaYEVGSFLSGILG-MVELGAQSITYeLAIIVYMIPSG-FSVAanvrVGNAL--------GAGNIDQAKK--SSAISL 340
Cdd:cd13123 231 ----SQINLLVDTILAsFLPEGSISALY-YADRLYQLPLGiFGVA----IATALlprlsrlaAAGDLDEFRRtlSRGLRL 301
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 341 IVTELFAVTFCVLLLGcKDLVGYIF----TTDRDiVALVAQVIPIYAVSHLFEGLActcgGIL-RG---TGNQKVGAIVN 412
Cdd:cd13123 302 VLFLLLPAAVGLIVLA-EPIVRLLFergaFTAED-TLMTASALAAYALGLPAFALV----KLLsRAfyaLKDTKTPVKIA 375
|
330 340
....*....|....*....|....*.
gi 166197685 413 AIGyyvIGLPIGIALMFAAKLGVIGL 438
Cdd:cd13123 376 VIA---VAVNILLNLLLIKPLGHVGL 398
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
279-427 |
1.09e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 44.90 E-value: 1.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 279 VGSFLSGILGMVELGAQSITYELAIIVYMIPSGFSVAANVRVGNALGAGNIDQAKKSSAISLIVTELFAVTFCVLLLGCK 358
Cdd:cd13145 31 VDTFFAGKISTEALAALSLSFPIFFIIIAIGVGIGTGTTALIGNALGAGDRRKARRYAAQGLSFGIILAILLTVIGLFAA 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 359 DLVGYIFTTDRDIVALVAQVIPIYAVSHLFEGLACTCGGILRGTGNQK-------VGAIVNAI-------GYYVI---GL 421
Cdd:cd13145 111 PPLFRLLGAEGDYLDLALEYMDVIFAGSIFFLLNFGLNGILNAQGDTKsyrnfliIGFFLNIIldplfifGGGGIpamGV 190
|
....*.
gi 166197685 422 PiGIAL 427
Cdd:cd13145 191 S-GIAL 195
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
35-241 |
2.15e-04 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 44.00 E-value: 2.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 35 LRALLVLAGPAFLAQLMMFLISFISSVFCGHL----GKLELDAVTL-------AIAVINVtGISVGHGLSSACDTLISQT 103
Cdd:cd13124 223 LKELLSYAIPITLSSLILPLLQLIDSFTVPRRlqaaGLSESEATALygiltgrAQPLVQL-PTVIATALSTSLVPAISEA 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 104 YGSQNLKHVGVILQRGTLILLLCCFPC-WALFINTEQILLLFRQDPDVSRLTQTYVMIFIpalpaaFLYTLQVKYLLNQG 182
Cdd:cd13124 302 YAKGDKKELRRRINQALRLTLLIGLPAaVGLAVLAEPINTLLFGDSEGGLILQILAPSIL------FLSLQQVTAAILQG 375
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 166197685 183 IVLPQI--MTGIAANLVNALANYVFLYHLhlGVMGSALANTISqFALAIFLFLYILWRRLH 241
Cdd:cd13124 376 LGKVKIpvINLLIGLLVKIVLNYVLIPIF--GIYGAAIATVIG-FLVAALLNLRALKKLLG 433
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
20-239 |
2.92e-04 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 43.60 E-value: 2.92e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 20 RRGLRCLLLPGFL-EELRALLVLAGPAFLAQLMMFLISFISSVFCGHLGKlelDAVT----------LAIAVInvtGISV 88
Cdd:cd13123 198 RLGFRFRPRLDFRdPGVRRVLKLMLPALLGVSVSQINLLVDTILASFLPE---GSISalyyadrlyqLPLGIF---GVAI 271
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 89 ghglSSACDTLISQTYGSQNLKHVGVILQRGTLILLLCCFPC--WALFINTEQILLLFRQ---DPDVSRLTQTYVMIFIP 163
Cdd:cd13123 272 ----ATALLPRLSRLAAAGDLDEFRRTLSRGLRLVLFLLLPAavGLIVLAEPIVRLLFERgafTAEDTLMTASALAAYAL 347
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 166197685 164 ALPAAFLYTLQVKYLLNQGIVLPQIMTGIAANLVNALANYVFLYHLhlGVMGSALANTISQFALAIFLFlYILWRR 239
Cdd:cd13123 348 GLPAFALVKLLSRAFYALKDTKTPVKIAVIAVAVNILLNLLLIKPL--GHVGLALATSLSAWVNALLLL-VLLRRR 420
|
|
| MATE_like_3 |
cd13148 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
260-459 |
3.00e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240553 [Multi-domain] Cd Length: 441 Bit Score: 43.41 E-value: 3.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 260 LRLAIPSMLMLCIEWWAYEVGSFLSGILGMVELGAQSITYELAIIVYMIPSG-FSVAANVRVGNALGAGNIDQAKKSSAI 338
Cdd:cd13148 15 LRLALPNILALLVQTLVGLAETYFVGQLGTDALAGVALVFPLLMLTQMMSNGaMGGGVSSAIARALGAGDRERAEALVWH 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 339 SLIVTELFAVTFCVL-LLGCKDLVGYIFTTDRDIVA-------LVAQVIPIYAVSHLfeglactcGGILRGTGNQKVGAI 410
Cdd:cd13148 95 ALVIALAGGLVFSLLfLLFGPALYRLLGGRGEALDAalaysnvLFSGAILIWLVNLL--------AAALRGTGNMRVPAL 166
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 166197685 411 VNAIGyYVIGLPIGIALMFAA----KLGVIGLWSGIIICTTCQTTCFLAFIAR 459
Cdd:cd13148 167 VTLVG-AVVQIPLSPGLILGWgplpRLGVAGAAVAAVLYYALAALVLLRYLAS 218
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
37-232 |
4.98e-04 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 42.63 E-value: 4.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 37 ALLVLAGPAFLAQLMMFLISFISSVFCGHLgkLELDAVTL--AIAVINVTGISVGHGLSSACDTLISQTYGSQNLKHVGV 114
Cdd:COG2244 174 LVLKYSLPLLLSGLLGLLLTNLDRLLLGAL--LGPAAVGIysAAYRLASLLLLLITALSQVLFPRLSRLLAEGDREELRR 251
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197685 115 ILQRGTLILLLCCFPCWA-LFINTEQILLLFRQDPDVSrlTQTYVMIFIPALPAAFLYTLQVKYLLNQGIVLPQIMTGIA 193
Cdd:COG2244 252 LYRKALRLLLLLGLPLALgLALLAPPLLSLLFGPEYAE--AAPVLPILALGALFLALSGVLSNLLLALGRTRLLLIISLI 329
|
170 180 190
....*....|....*....|....*....|....*....
gi 166197685 194 ANLVNALANYVFLYhlHLGVMGSALANTISQFALAIFLF 232
Cdd:COG2244 330 GAVLNLVLNLLLIP--RYGLVGAAIATLLSYLVLLLLLL 366
|
|
| |
