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Conserved domains on  [gi|23956162|ref|NP_080488|]
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1-acyl-sn-glycerol-3-phosphate acyltransferase beta precursor [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
62-261 7.29e-53

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


:

Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 171.35  E-value: 7.29e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956162  62 IISWFVRSFKYVYGLRFEVSGQKKLEVDGPCVIISNHQSILDMMGLMEILPKRCVQIAKRELMFTGPVGLIMYLGGVYFI 141
Cdd:COG0204  15 LVRLWARLLLRLLGVRVRVEGLENLPADGPVLIVANHQSWLDILLLLAALPRPVRFVAKKELFKIPLLGWLLRALGAIPV 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956162 142 NRQQARTAMSVMADLGDLMvKENLKVWIYPEGTRNDNGDLLPFKKGAFYLAIQAQVPIIPVVYSSfSSFYNVKTKLFTSG 221
Cdd:COG0204  95 DRSKRRAALRALRQAVEAL-KAGESLVIFPEGTRSPDGRLLPFKTGAARLALEAGVPIVPVAIDG-TERALPKGFLPRPG 172
                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 23956162 222 TIKVQVLDAVPTNGLTDADVTKLVDTCYQSMRATFLQISQ 261
Cdd:COG0204 173 KVTVRIGPPIDPSDLEGEDRRELAERLRAAIEALLAELRA 212
 
Name Accession Description Interval E-value
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
62-261 7.29e-53

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 171.35  E-value: 7.29e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956162  62 IISWFVRSFKYVYGLRFEVSGQKKLEVDGPCVIISNHQSILDMMGLMEILPKRCVQIAKRELMFTGPVGLIMYLGGVYFI 141
Cdd:COG0204  15 LVRLWARLLLRLLGVRVRVEGLENLPADGPVLIVANHQSWLDILLLLAALPRPVRFVAKKELFKIPLLGWLLRALGAIPV 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956162 142 NRQQARTAMSVMADLGDLMvKENLKVWIYPEGTRNDNGDLLPFKKGAFYLAIQAQVPIIPVVYSSfSSFYNVKTKLFTSG 221
Cdd:COG0204  95 DRSKRRAALRALRQAVEAL-KAGESLVIFPEGTRSPDGRLLPFKTGAARLALEAGVPIVPVAIDG-TERALPKGFLPRPG 172
                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 23956162 222 TIKVQVLDAVPTNGLTDADVTKLVDTCYQSMRATFLQISQ 261
Cdd:COG0204 173 KVTVRIGPPIDPSDLEGEDRRELAERLRAAIEALLAELRA 212
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
67-240 1.08e-51

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 167.45  E-value: 1.08e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956162  67 VRSFKYVYGLRFEVSGQKKLEVDGPCVIISNHQSILDMMGLMEILPKRCVQIAKRELMFTGPVGLIMYLGGVYFINRQQA 146
Cdd:cd07989   1 LRLLLRLLGVRVRVEGLENLPPKGPVIIVANHQSYLDPLVLGAALPRPIRFVAKKELFKIPFLGWLLRLLGAIPIDRGNG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956162 147 RTAMSVMADLGDLMvKENLKVWIYPEGTRNDNGDLLPFKKGAFYLAIQAQVPIIPVVYSSFSSFYNVKTKLFTSGTIKVQ 226
Cdd:cd07989  81 RSAREALREAIEAL-KEGESVVIFPEGTRSRDGELLPFKSGAFRLAKEAGVPIVPVAISGTWGSLPKGKKLPRPGRVTVR 159
                       170
                ....*....|....
gi 23956162 227 VLDAVPTNGLTDAD 240
Cdd:cd07989 160 IGEPIPPEGLELAE 173
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
77-205 1.58e-43

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 144.73  E-value: 1.58e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956162    77 RFEVSGQKKLEVDGPCVIISNHQSILDMMGLMEILPK---RCVQIAKRELMFTGPVGLIMYLGGVYFINRQQARTAMSVM 153
Cdd:pfam01553   1 RIEVHGLENLPRGGPAIVVANHQSYLDVLLLSLALYKrgrPLVFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKDAAGTL 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 23956162   154 ADLGDLMvKENLKVWIYPEGTRNDNGDLLPFKKGAFYLAIQAQVPIIPVVYS 205
Cdd:pfam01553  81 EYLVELL-REGKLVVIFPEGTRSREGELLPFKKGAFRLAIEAGVPIVPVAIS 131
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
92-205 3.55e-35

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 122.46  E-value: 3.55e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956162     92 CVIISNHQSILDMMGLMEILPK---RCVQIAKRELMFTGPVGLIMYLGGVYFINRQQARTAMSVMADLGDLMvKENLKVW 168
Cdd:smart00563   1 ALVVANHQSFLDPLVLSALLPRklgRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGRKARAALREAVELL-KEGEWLL 79
                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 23956162    169 IYPEGTRNDNGDLLPFKKGAFYLAIQAQVPIIPVVYS 205
Cdd:smart00563  80 IFPEGTRSRPGKLLPFKKGAARLALEAGVPIVPVAIR 116
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
75-205 1.95e-34

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 121.30  E-value: 1.95e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956162    75 GLRFEVSGQKKLEVDGPCVIISNHQSILDMMGLMEILPKRCVQIAKRELMFTGPVGLIMYLGGVYFINRQQARTAMSVMA 154
Cdd:TIGR00530   1 GLKVEVVGPENLPAKSPVLVVANHQSNLDPLTLSAAFPPPIVFIAKKELKWIPFFGIMLWLTGAIFIDRENIRAIATALK 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 23956162   155 DLGDLMvKENLKVWIYPEGTRNDNGDLLPFKKGAFYLAIQAQVPIIPVVYS 205
Cdd:TIGR00530  81 AAIEVL-KQGRSIGVFPEGTRSRGRDILPFKKGAFHIAIKAGVPILPVVLS 130
PRK15018 PRK15018
1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional
32-268 4.67e-23

1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional


Pssm-ID: 184979  Cd Length: 245  Bit Score: 94.70  E-value: 4.67e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956162   32 LYCVLCLSFsaaASIVCLLrhGGRTVDNMSIISWFVRSFKYVYGLRFEVSGQKKLEVDGPCVIISNHQSILDMMGLMEIL 111
Cdd:PRK15018  12 IYSILVCVF---GSIYCLF--SPRNPKHVATFGHMFGRLAPLFGLKVECRKPADAESYGNAIYIANHQNNYDMVTASNIV 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956162  112 PKRCVQIAKRELMFTGPVGLIMYLGGVYFINRQQARTAMSVMADLGDLMVKENLKVWIYPEGTRNDNGDLLPFKKGAFYL 191
Cdd:PRK15018  87 QPPTVTVGKKSLLWIPFFGQLYWLTGNLLIDRNNRTKAHGTIAEVVNHFKKRRISIWMFPEGTRSRGRGLLPFKTGAFHA 166
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 23956162  192 AIQAQVPIIPVVYSSFSSfyNVKTKLFTSGTIKVQVLDAVPTNGLTDADVTKLVDTCYQSMRATFLQISQIPQENSA 268
Cdd:PRK15018 167 AIAAGVPIIPVCVSTTSN--KINLNRLHNGLVIVEMLPPIDVSQYGKDQVRELAAHCRSIMEQKIAELDKEVAEREA 241
 
Name Accession Description Interval E-value
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
62-261 7.29e-53

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 171.35  E-value: 7.29e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956162  62 IISWFVRSFKYVYGLRFEVSGQKKLEVDGPCVIISNHQSILDMMGLMEILPKRCVQIAKRELMFTGPVGLIMYLGGVYFI 141
Cdd:COG0204  15 LVRLWARLLLRLLGVRVRVEGLENLPADGPVLIVANHQSWLDILLLLAALPRPVRFVAKKELFKIPLLGWLLRALGAIPV 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956162 142 NRQQARTAMSVMADLGDLMvKENLKVWIYPEGTRNDNGDLLPFKKGAFYLAIQAQVPIIPVVYSSfSSFYNVKTKLFTSG 221
Cdd:COG0204  95 DRSKRRAALRALRQAVEAL-KAGESLVIFPEGTRSPDGRLLPFKTGAARLALEAGVPIVPVAIDG-TERALPKGFLPRPG 172
                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 23956162 222 TIKVQVLDAVPTNGLTDADVTKLVDTCYQSMRATFLQISQ 261
Cdd:COG0204 173 KVTVRIGPPIDPSDLEGEDRRELAERLRAAIEALLAELRA 212
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
67-240 1.08e-51

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 167.45  E-value: 1.08e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956162  67 VRSFKYVYGLRFEVSGQKKLEVDGPCVIISNHQSILDMMGLMEILPKRCVQIAKRELMFTGPVGLIMYLGGVYFINRQQA 146
Cdd:cd07989   1 LRLLLRLLGVRVRVEGLENLPPKGPVIIVANHQSYLDPLVLGAALPRPIRFVAKKELFKIPFLGWLLRLLGAIPIDRGNG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956162 147 RTAMSVMADLGDLMvKENLKVWIYPEGTRNDNGDLLPFKKGAFYLAIQAQVPIIPVVYSSFSSFYNVKTKLFTSGTIKVQ 226
Cdd:cd07989  81 RSAREALREAIEAL-KEGESVVIFPEGTRSRDGELLPFKSGAFRLAKEAGVPIVPVAISGTWGSLPKGKKLPRPGRVTVR 159
                       170
                ....*....|....
gi 23956162 227 VLDAVPTNGLTDAD 240
Cdd:cd07989 160 IGEPIPPEGLELAE 173
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
77-205 1.58e-43

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 144.73  E-value: 1.58e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956162    77 RFEVSGQKKLEVDGPCVIISNHQSILDMMGLMEILPK---RCVQIAKRELMFTGPVGLIMYLGGVYFINRQQARTAMSVM 153
Cdd:pfam01553   1 RIEVHGLENLPRGGPAIVVANHQSYLDVLLLSLALYKrgrPLVFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKDAAGTL 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 23956162   154 ADLGDLMvKENLKVWIYPEGTRNDNGDLLPFKKGAFYLAIQAQVPIIPVVYS 205
Cdd:pfam01553  81 EYLVELL-REGKLVVIFPEGTRSREGELLPFKKGAFRLAIEAGVPIVPVAIS 131
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
92-205 3.55e-35

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 122.46  E-value: 3.55e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956162     92 CVIISNHQSILDMMGLMEILPK---RCVQIAKRELMFTGPVGLIMYLGGVYFINRQQARTAMSVMADLGDLMvKENLKVW 168
Cdd:smart00563   1 ALVVANHQSFLDPLVLSALLPRklgRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGRKARAALREAVELL-KEGEWLL 79
                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 23956162    169 IYPEGTRNDNGDLLPFKKGAFYLAIQAQVPIIPVVYS 205
Cdd:smart00563  80 IFPEGTRSRPGKLLPFKKGAARLALEAGVPIVPVAIR 116
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
75-205 1.95e-34

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 121.30  E-value: 1.95e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956162    75 GLRFEVSGQKKLEVDGPCVIISNHQSILDMMGLMEILPKRCVQIAKRELMFTGPVGLIMYLGGVYFINRQQARTAMSVMA 154
Cdd:TIGR00530   1 GLKVEVVGPENLPAKSPVLVVANHQSNLDPLTLSAAFPPPIVFIAKKELKWIPFFGIMLWLTGAIFIDRENIRAIATALK 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 23956162   155 DLGDLMvKENLKVWIYPEGTRNDNGDLLPFKKGAFYLAIQAQVPIIPVVYS 205
Cdd:TIGR00530  81 AAIEVL-KQGRSIGVFPEGTRSRGRDILPFKKGAFHIAIKAGVPILPVVLS 130
PRK15018 PRK15018
1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional
32-268 4.67e-23

1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional


Pssm-ID: 184979  Cd Length: 245  Bit Score: 94.70  E-value: 4.67e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956162   32 LYCVLCLSFsaaASIVCLLrhGGRTVDNMSIISWFVRSFKYVYGLRFEVSGQKKLEVDGPCVIISNHQSILDMMGLMEIL 111
Cdd:PRK15018  12 IYSILVCVF---GSIYCLF--SPRNPKHVATFGHMFGRLAPLFGLKVECRKPADAESYGNAIYIANHQNNYDMVTASNIV 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956162  112 PKRCVQIAKRELMFTGPVGLIMYLGGVYFINRQQARTAMSVMADLGDLMVKENLKVWIYPEGTRNDNGDLLPFKKGAFYL 191
Cdd:PRK15018  87 QPPTVTVGKKSLLWIPFFGQLYWLTGNLLIDRNNRTKAHGTIAEVVNHFKKRRISIWMFPEGTRSRGRGLLPFKTGAFHA 166
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 23956162  192 AIQAQVPIIPVVYSSFSSfyNVKTKLFTSGTIKVQVLDAVPTNGLTDADVTKLVDTCYQSMRATFLQISQIPQENSA 268
Cdd:PRK15018 167 AIAAGVPIIPVCVSTTSN--KINLNRLHNGLVIVEMLPPIDVSQYGKDQVRELAAHCRSIMEQKIAELDKEVAEREA 241
PLN02901 PLN02901
1-acyl-sn-glycerol-3-phosphate acyltransferase
79-203 2.41e-18

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 215488 [Multi-domain]  Cd Length: 214  Bit Score: 81.32  E-value: 2.41e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956162   79 EVSGQKKL-EVDGPCVIISNHQSILDMMGLMEIlpKRCVQ-IAKRELMFTGPVGLIMYLGGVYFINRQQARTAMSVMADL 156
Cdd:PLN02901  38 EVEGLENLpSPDEPAVYVSNHQSFLDIYTLFHL--GRPFKfISKTSIFLIPIIGWAMYMTGHIPLKRMDRRSQLECLKRC 115
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 23956162  157 GDLmVKENLKVWIYPEGTRNDNGDLLPFKKGAFYLAIQAQVPIIPVV 203
Cdd:PLN02901 116 MEL-LKKGASVFFFPEGTRSKDGKLAAFKKGAFSVAAKTGVPVVPIT 161
LPLAT cd06551
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
75-203 6.57e-15

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


Pssm-ID: 153244 [Multi-domain]  Cd Length: 187  Bit Score: 71.29  E-value: 6.57e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956162  75 GLRFEVSGQKKLEVDGPCVIISNHQSILDMMGLM----EILPKRCVQIAKRELMFTGPVgliMYLGGVYFINRQQARTAM 150
Cdd:cd06551  11 FVRLEVKGPPPPPGGGPVLFVSNHSSWWDGLILFllleRGLRRDVYGLMDEELLERYPF---FTRLGAFSVDRDSPRSAA 87
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 23956162 151 SVMADLGDLMVKENLKVWIYPEGTRNDNGD-LLPFKKGAFYLAIQAQVPIIPVV 203
Cdd:cd06551  88 KSLKYVARLLSKPGSVVWIFPEGTRTRRDKrPLQFKPGVAHLAEKAGVPIVPVA 141
LPLAT_LPCAT1-like cd07991
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; ...
67-212 5.94e-12

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as lysophosphatidylcholine acyltransferase 1 (LPCAT-1), glycerol-3-phosphate acyltransferase 3 (GPAT3), and similar sequences.


Pssm-ID: 153253 [Multi-domain]  Cd Length: 211  Bit Score: 63.39  E-value: 5.94e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956162  67 VRSFKYVYGL-RFEVSGQKKLEVDGPcVIISNHQSILDMMGLMEILPkrCVQIAKRELMFTGPVGLIM-YLGGVYF---- 140
Cdd:cd07991   1 ARVLLFAFGFyVIKVHGKPDPPEAPR-IIVANHTSFIDPLILFSDLF--PSIVAKKELGKLPFIGTILrALGCIFVdrse 77
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 23956162 141 -INRQQARTAMSVMADLGDlmvkeNLKVWIYPEGTRNDNGDLLPFKKGAFYLaiqaQVPIIPVV--YSSFSSFYN 212
Cdd:cd07991  78 pKDRKKVVEEIKERATDPN-----WPPILIFPEGTTTNGKALIMFKKGAFEP----GVPVQPVAirYPNKFVDAF 143
LPLAT_AAK14816-like cd07992
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
63-202 2.92e-10

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown AAK14816-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized glycerol-3-phosphate acyltransferases such as the Plasmodium falciparum locus AAK14816 putative acyltransferase, and similar proteins.


Pssm-ID: 153254 [Multi-domain]  Cd Length: 203  Bit Score: 58.43  E-value: 2.92e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956162  63 ISWFVRSFKYVYGLRFEVSGQKKLEVDGPCVIISNHQ-SILDMMGLMEILPKRCVQIAKRELMFTGPVGLIMYLGGVYFI 141
Cdd:cd07992   1 VRLLSRVILRIYFRRITVVGRENVPKDGPVIFLGNHPnALIDPLLLAATLRRPVRFLAKADLFKNPLIGWLLESFGAIPV 80
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 23956162 142 NRQQ----ARTAMSVMADLGDLmVKENLK----VWIYPEGTRNDNGDLLPFKKGAFYLAIQA------QVPIIPV 202
Cdd:cd07992  81 YRPKdlarGGIGKISNAAVFDA-VGEALKaggaIGIFPEGGSHDRPRLLPLKAGAARMALEAleagqkDVKIVPV 154
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
70-175 5.88e-10

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 57.25  E-value: 5.88e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956162  70 FKYVYGLRFEVSGQKKLEVDGPCVIISNHQSILDMMGLMEILPKRCVQ-----IAKRELMFTGPVGLIMYLGGVYFINRQ 144
Cdd:cd07990   4 FEWLSGVKVVVYGDEPKLPKERALIISNHRSEVDWLVLWMLADRFGRLgrlkiVLKDSLKYPPLGGWGWQLGEFIFLKRK 83
                        90       100       110
                ....*....|....*....|....*....|....*..
gi 23956162 145 ----QARTAMSVmadlgDLMVKENLKVW--IYPEGTR 175
Cdd:cd07990  84 wekdEKTIKRQL-----KRLKDSPEPFWllIFPEGTR 115
LPLAT_ABO13168-like cd07988
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
93-202 2.78e-07

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized phospholipid/glycerol acyltransferases such as the Acinetobacter baumannii ATCC 17978 locus ABO13168 putative acyltransferase, and similar proteins.


Pssm-ID: 153250 [Multi-domain]  Cd Length: 163  Bit Score: 49.14  E-value: 2.78e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956162  93 VIISNHQSILD---MMGLMEILpKRCVQIAKRELMFTGPVGLIM-YLGGVYfINRQQARTAMSVMADlgDLMVKENLKVW 168
Cdd:cd07988  24 VIGAPHTSNWDfvlGLLAAFAL-GLKISFLGKHSLFKPPLGPFMrWLGGIP-VDRSRAGGLVEQVVE--EFRRREEFVLA 99
                        90       100       110
                ....*....|....*....|....*....|....
gi 23956162 169 IYPEGTRNDNGdllPFKKGAFYLAIQAQVPIIPV 202
Cdd:cd07988 100 IAPEGTRSKVD---KWKTGFYHIARGAGVPILLV 130
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
62-208 3.48e-07

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 51.08  E-value: 3.48e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956162    62 IISWFVRSFKYvyglRFEVSGQKKLEVDGPCVIISNHQSILDMMGLMEILPKRCVQIAKRELMFTGPVGLIMYLGGVYFI 141
Cdd:PRK08633  417 FLLLLLMHTRY----RLRVEGRENIPAKGGALLLGNHVSWIDWALLQAASPRPIRFVMERSIYEKWYLKWFFKLFGVIPI 492
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 23956162   142 NRQQARTAMSVMA---DLGDLmvkenlkVWIYPEGTRNDNGDLLPFKKGaFYLAIQ-AQVPIIPvVY------SSFS 208
Cdd:PRK08633  493 SSGGSKESLEFIRkalDDGEV-------VCIFPEGAITRNGQLNEFKRG-FELIVKgTDVPIIP-FYirglwgSIFS 560
LPLAT_MGAT-like cd07987
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; ...
70-202 1.08e-03

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this suubgroup are such LPLATs as 2-acylglycerol O-acyltransferase (MGAT), and similar proteins.


Pssm-ID: 153249 [Multi-domain]  Cd Length: 212  Bit Score: 39.19  E-value: 1.08e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956162  70 FKYVYgLRFEVSGQKKLEVDGPCVIISNHqSILDMMGLM------EILPKRCVQIAKRELMFTGPVG--LIMYLGGVyfi 141
Cdd:cd07987   1 HRKYF-RVYEVRGLENIPDEGPALLVHPH-GGLPIDGALlaaaflLLFPGRLPRALADHFLFPLPGLrdLLRRLGAV--- 75
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 23956162 142 nRQQARTAMSVMADlGDLMVkenlkvwIYPEGTR-------NDNGDLLPFKKGAFYLAIQAQVPIIPV 202
Cdd:cd07987  76 -PGSRENCVRLLRE-GELVL-------IFPGGARealkskrEEYYLLWKKRKGFARLALRAGAPIVPV 134
PLN02833 PLN02833
glycerol acyltransferase family protein
93-219 4.45e-03

glycerol acyltransferase family protein


Pssm-ID: 215447  Cd Length: 376  Bit Score: 38.22  E-value: 4.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956162   93 VIISNHQSILDMMGLMEILPkrCVQIAKRElmfTGPVGLIM-----YLGGVYFiNRQQARTAMSVMADLGD-LMVKENLK 166
Cdd:PLN02833 166 VFVANHTSMIDFIVLEQMTP--FAVIMQKH---PGWVGFLQntileSVGCIWF-NRTEAKDREVVAKKLRDhVQDPDRNP 239
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 23956162  167 VWIYPEGTRNDNGDLLPFKKGAFYLAiqAQVPIIPVVYSSF--SSFYNVKTKLFT 219
Cdd:PLN02833 240 LLIFPEGTCVNNEYTVMFKKGAFELG--CTVCPIAIKYNKIfvDAFWNSRKQSFT 292
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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