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Conserved domains on  [gi|13386020|ref|NP_080800|]
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mid1-interacting protein 1 [Mus musculus]

Protein Classification

Spot_14 domain-containing protein( domain architecture ID 10537235)

Spot_14 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Spot_14 pfam07084
Thyroid hormone-inducible hepatic protein Spot 14; This family consists of several thyroid ...
 3-178 1.50e-91

Thyroid hormone-inducible hepatic protein Spot 14; This family consists of several thyroid hormone-inducible hepatic protein (Spot 14 or S14) sequences. Mainly expressed in tissues that synthesize triglycerides, the mRNA coding for Spot 14 has been shown to be increased in rat liver by insulin, dietary carbohydrates, glucose in hepatocyte culture medium, as well as thyroid hormone. In contrast, dietary fats and polyunsaturated fatty acids, have been shown to decrease the amount of Spot 14 mRNA, while an elevated level of cAMP acts as a dominant negative factor. In addition, liver-specific factors or chromatin organization of the gene have been shown to contribute to the regulation of its expression. Spot 14 protein is thought to be required for induction of hepatic lipogenesis.


:

Pssm-ID: 462085  Cd Length: 151  Bit Score: 263.43  E-value: 1.50e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13386020     3 QICDTYNQKHSLFNAMNRFIGAVNNMDQTVMVPSLLRDVPLSEPEIDEVsvevggsggcleerttpapsPGSANESFFAP 82
Cdd:pfam07084   1 QICDSYPQKNSLLNAMNRFIAAVNNMDQTVMVPSLLRDVPLEEEGEDAQ--------------------VGNNNPSFFAG 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13386020    83 SRDMYSHYVLLKSIRNDIEWGVLHQPSsppagseestWKPKD----ILVGLSHLESADA-GEEDLEQQFHYHLRGLHTVL 157
Cdd:pfam07084  61 ARDMYSYYTLLKSIRNDIEWGLLPREE----------WRKKDagenSAAETSELEEEDAeGELDLEAQFHYHLSGLHHVL 130

                         170       180
                  ....*....|....*....|.
gi 13386020   158 SKLTRKANILTNRYKQEIGFS 178
Cdd:pfam07084 131 SKLTRKANELTNRYKEEIGQG 151
 
Name Accession Description Interval E-value
Spot_14 pfam07084
Thyroid hormone-inducible hepatic protein Spot 14; This family consists of several thyroid ...
 3-178 1.50e-91

Thyroid hormone-inducible hepatic protein Spot 14; This family consists of several thyroid hormone-inducible hepatic protein (Spot 14 or S14) sequences. Mainly expressed in tissues that synthesize triglycerides, the mRNA coding for Spot 14 has been shown to be increased in rat liver by insulin, dietary carbohydrates, glucose in hepatocyte culture medium, as well as thyroid hormone. In contrast, dietary fats and polyunsaturated fatty acids, have been shown to decrease the amount of Spot 14 mRNA, while an elevated level of cAMP acts as a dominant negative factor. In addition, liver-specific factors or chromatin organization of the gene have been shown to contribute to the regulation of its expression. Spot 14 protein is thought to be required for induction of hepatic lipogenesis.


Pssm-ID: 462085  Cd Length: 151  Bit Score: 263.43  E-value: 1.50e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13386020     3 QICDTYNQKHSLFNAMNRFIGAVNNMDQTVMVPSLLRDVPLSEPEIDEVsvevggsggcleerttpapsPGSANESFFAP 82
Cdd:pfam07084   1 QICDSYPQKNSLLNAMNRFIAAVNNMDQTVMVPSLLRDVPLEEEGEDAQ--------------------VGNNNPSFFAG 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13386020    83 SRDMYSHYVLLKSIRNDIEWGVLHQPSsppagseestWKPKD----ILVGLSHLESADA-GEEDLEQQFHYHLRGLHTVL 157
Cdd:pfam07084  61 ARDMYSYYTLLKSIRNDIEWGLLPREE----------WRKKDagenSAAETSELEEEDAeGELDLEAQFHYHLSGLHHVL 130

                         170       180
                  ....*....|....*....|.
gi 13386020   158 SKLTRKANILTNRYKQEIGFS 178
Cdd:pfam07084 131 SKLTRKANELTNRYKEEIGQG 151
 
Name Accession Description Interval E-value
Spot_14 pfam07084
Thyroid hormone-inducible hepatic protein Spot 14; This family consists of several thyroid ...
 3-178 1.50e-91

Thyroid hormone-inducible hepatic protein Spot 14; This family consists of several thyroid hormone-inducible hepatic protein (Spot 14 or S14) sequences. Mainly expressed in tissues that synthesize triglycerides, the mRNA coding for Spot 14 has been shown to be increased in rat liver by insulin, dietary carbohydrates, glucose in hepatocyte culture medium, as well as thyroid hormone. In contrast, dietary fats and polyunsaturated fatty acids, have been shown to decrease the amount of Spot 14 mRNA, while an elevated level of cAMP acts as a dominant negative factor. In addition, liver-specific factors or chromatin organization of the gene have been shown to contribute to the regulation of its expression. Spot 14 protein is thought to be required for induction of hepatic lipogenesis.


Pssm-ID: 462085  Cd Length: 151  Bit Score: 263.43  E-value: 1.50e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13386020     3 QICDTYNQKHSLFNAMNRFIGAVNNMDQTVMVPSLLRDVPLSEPEIDEVsvevggsggcleerttpapsPGSANESFFAP 82
Cdd:pfam07084   1 QICDSYPQKNSLLNAMNRFIAAVNNMDQTVMVPSLLRDVPLEEEGEDAQ--------------------VGNNNPSFFAG 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13386020    83 SRDMYSHYVLLKSIRNDIEWGVLHQPSsppagseestWKPKD----ILVGLSHLESADA-GEEDLEQQFHYHLRGLHTVL 157
Cdd:pfam07084  61 ARDMYSYYTLLKSIRNDIEWGLLPREE----------WRKKDagenSAAETSELEEEDAeGELDLEAQFHYHLSGLHHVL 130

                         170       180
                  ....*....|....*....|.
gi 13386020   158 SKLTRKANILTNRYKQEIGFS 178
Cdd:pfam07084 131 SKLTRKANELTNRYKEEIGQG 151
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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