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Conserved domains on  [gi|27754038|ref|NP_081134|]
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mitochondrial inner membrane protease ATP23 homolog isoform 2 [Mus musculus]

Protein Classification

mitochondrial inner membrane protease ATP23( domain architecture ID 10561080)

mitochondrial inner membrane protease ATP23 is an M76 family metallopeptidase that has a dual role in the assembly of mitochondrial ATPase: acting as a protease that removes the N-terminal 10 residues of mitochondrial ATPase CF(0) subunit 6 (ATP6) at the intermembrane space side; and is also involved in the correct assembly of the membrane-embedded ATPase CF(0) particle

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Peptidase_M76 pfam09768
Peptidase M76 family; This is a family of metalloproteases. Proteins in this family are also ...
 52-192 1.09e-62

Peptidase M76 family; This is a family of metalloproteases. Proteins in this family are also annotated as Ku70-binding proteins.


:

Pssm-ID: 430811  Cd Length: 168  Bit Score: 191.99  E-value: 1.09e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27754038    52 CPLMLQKTLDTNPYVKLLLDAMKHSGCAVNRgRHFSCEVCDGNVSGGFDaSTSQIVLCENNIRNQAHMGRVVTHELIHAF 131
Cdd:pfam09768   3 CEKNVDKLLKYSPTVRFMLKALKKLGCPVDP-RRIVCEPCDGRVSGGFD-PEKGIVLCQNRIRSKDHLEDTLAHELIHAY 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 27754038   132 DHCRAHVHWfTNIRHLACSEIRAASLSGDCSLVNELFRLRFGLKQHHQietSCVSRPAMNS 192
Cdd:pfam09768  81 DHCRFKVDW-KNLRHHACSEIRAANLSGDCRFKRELLRGGFKFTKQHQ---ECVKRRAILS 137
 
Name Accession Description Interval E-value
Peptidase_M76 pfam09768
Peptidase M76 family; This is a family of metalloproteases. Proteins in this family are also ...
 52-192 1.09e-62

Peptidase M76 family; This is a family of metalloproteases. Proteins in this family are also annotated as Ku70-binding proteins.


Pssm-ID: 430811  Cd Length: 168  Bit Score: 191.99  E-value: 1.09e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27754038    52 CPLMLQKTLDTNPYVKLLLDAMKHSGCAVNRgRHFSCEVCDGNVSGGFDaSTSQIVLCENNIRNQAHMGRVVTHELIHAF 131
Cdd:pfam09768   3 CEKNVDKLLKYSPTVRFMLKALKKLGCPVDP-RRIVCEPCDGRVSGGFD-PEKGIVLCQNRIRSKDHLEDTLAHELIHAY 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 27754038   132 DHCRAHVHWfTNIRHLACSEIRAASLSGDCSLVNELFRLRFGLKQHHQietSCVSRPAMNS 192
Cdd:pfam09768  81 DHCRFKVDW-KNLRHHACSEIRAANLSGDCRFKRELLRGGFKFTKQHQ---ECVKRRAILS 137
 
Name Accession Description Interval E-value
Peptidase_M76 pfam09768
Peptidase M76 family; This is a family of metalloproteases. Proteins in this family are also ...
 52-192 1.09e-62

Peptidase M76 family; This is a family of metalloproteases. Proteins in this family are also annotated as Ku70-binding proteins.


Pssm-ID: 430811  Cd Length: 168  Bit Score: 191.99  E-value: 1.09e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27754038    52 CPLMLQKTLDTNPYVKLLLDAMKHSGCAVNRgRHFSCEVCDGNVSGGFDaSTSQIVLCENNIRNQAHMGRVVTHELIHAF 131
Cdd:pfam09768   3 CEKNVDKLLKYSPTVRFMLKALKKLGCPVDP-RRIVCEPCDGRVSGGFD-PEKGIVLCQNRIRSKDHLEDTLAHELIHAY 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 27754038   132 DHCRAHVHWfTNIRHLACSEIRAASLSGDCSLVNELFRLRFGLKQHHQietSCVSRPAMNS 192
Cdd:pfam09768  81 DHCRFKVDW-KNLRHHACSEIRAANLSGDCRFKRELLRGGFKFTKQHQ---ECVKRRAILS 137
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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