NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|110625726|ref|NP_081220|]
View 

alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 isoform a [Mus musculus]

Protein Classification

2OG-Fe(II) oxygenase family protein( domain architecture ID 229412)

2OG-Fe(II) oxygenase family protein belongs to the large and diverse Fe(II)- and 2-oxoglutarate (2-OG)-dependent dioxygenase superfamily and may share a common reaction mechanism, using Fe(II) and the cosubstrate 2-OG in the active site to activate oxygen, resulting in the two-electron oxidation of a target substrate

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
AlkB COG3145
Alkylated DNA repair dioxygenase AlkB [Replication, recombination and repair];
90-279 3.90e-70

Alkylated DNA repair dioxygenase AlkB [Replication, recombination and repair];


:

Pssm-ID: 442379  Cd Length: 200  Bit Score: 215.02  E-value: 3.90e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625726  90 VCLYPGFVDLKEADWILEQLCKDVPWKQ---RMGIRedvTYPQPRLTAWYG--ELPYTYSRITMEPNPhWLPVLWTLKSR 164
Cdd:COG3145   18 AVYLPGFLSPEEADALLAALRAEAPWRQpviPIFGK---TMSVPRLNAWYGwvGAGYRYSGTDPEPPP-WPPALLALKRR 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625726 165 IEENTSHTFNSLLCNFYRDEKDSVDWHSDDEPSLGSCPVIASLSFGATRTFEMRKKpppeENGDytyvERVKIPLDHGTL 244
Cdd:COG3145   94 VEAAAGFPFNSCLLNLYRDGQDRMGWHQDDEEELGFNPPIASVSLGATRRFRFGHK----ERKD----PTRSLPLEHGDL 165

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 110625726 245 LIMEGATQADWQHRVPKEYHSRQPRVNLTFRTVYP 279
Cdd:COG3145  166 LVMGGPTQLAWQHGVPKTKKGTGPRINLTFRRIGP 200
 
Name Accession Description Interval E-value
AlkB COG3145
Alkylated DNA repair dioxygenase AlkB [Replication, recombination and repair];
90-279 3.90e-70

Alkylated DNA repair dioxygenase AlkB [Replication, recombination and repair];


Pssm-ID: 442379  Cd Length: 200  Bit Score: 215.02  E-value: 3.90e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625726  90 VCLYPGFVDLKEADWILEQLCKDVPWKQ---RMGIRedvTYPQPRLTAWYG--ELPYTYSRITMEPNPhWLPVLWTLKSR 164
Cdd:COG3145   18 AVYLPGFLSPEEADALLAALRAEAPWRQpviPIFGK---TMSVPRLNAWYGwvGAGYRYSGTDPEPPP-WPPALLALKRR 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625726 165 IEENTSHTFNSLLCNFYRDEKDSVDWHSDDEPSLGSCPVIASLSFGATRTFEMRKKpppeENGDytyvERVKIPLDHGTL 244
Cdd:COG3145   94 VEAAAGFPFNSCLLNLYRDGQDRMGWHQDDEEELGFNPPIASVSLGATRRFRFGHK----ERKD----PTRSLPLEHGDL 165

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 110625726 245 LIMEGATQADWQHRVPKEYHSRQPRVNLTFRTVYP 279
Cdd:COG3145  166 LVMGGPTQLAWQHGVPKTKKGTGPRINLTFRRIGP 200
2OG-FeII_Oxy_2 pfam13532
2OG-Fe(II) oxygenase superfamily;
90-275 1.03e-29

2OG-Fe(II) oxygenase superfamily;


Pssm-ID: 433285  Cd Length: 191  Bit Score: 110.87  E-value: 1.03e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625726   90 VCLYPGFVDLKEADWILEQLCKDVPWKQ---RMGIREDVTYPQPRLTAWYGELP-YTYSR---ITMEPNPHWLPVLWTLK 162
Cdd:pfam13532   2 LVLLPGFLSPEEAAELLRELLEEGPFRQpttQGGRPMSVRMTNCGQLGWVTDGPgYRYSGvdpVTGEPWPPFPEALLQLA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625726  163 SRIEENT---SHTFNSLLCNFYRDeKDSVDWHSD-DEPSLGSCpvIASLSFGATRTFEMRKKPPPEengdytyvERVKIP 238
Cdd:pfam13532  82 ERLAAEAgypGWSPNACLVNFYRD-GARMGLHQDrDESGPGAP--IVSLSLGASATFRFGGKSRSD--------PTISLR 150

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 110625726  239 LDHGTLLIMEGATQADWqHRVPKEYHSRQP-----RVNLTFR 275
Cdd:pfam13532 151 LESGDVLVMGGESRLAY-HGVPPIRRGTHPllgggRINLTFR 191
 
Name Accession Description Interval E-value
AlkB COG3145
Alkylated DNA repair dioxygenase AlkB [Replication, recombination and repair];
90-279 3.90e-70

Alkylated DNA repair dioxygenase AlkB [Replication, recombination and repair];


Pssm-ID: 442379  Cd Length: 200  Bit Score: 215.02  E-value: 3.90e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625726  90 VCLYPGFVDLKEADWILEQLCKDVPWKQ---RMGIRedvTYPQPRLTAWYG--ELPYTYSRITMEPNPhWLPVLWTLKSR 164
Cdd:COG3145   18 AVYLPGFLSPEEADALLAALRAEAPWRQpviPIFGK---TMSVPRLNAWYGwvGAGYRYSGTDPEPPP-WPPALLALKRR 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625726 165 IEENTSHTFNSLLCNFYRDEKDSVDWHSDDEPSLGSCPVIASLSFGATRTFEMRKKpppeENGDytyvERVKIPLDHGTL 244
Cdd:COG3145   94 VEAAAGFPFNSCLLNLYRDGQDRMGWHQDDEEELGFNPPIASVSLGATRRFRFGHK----ERKD----PTRSLPLEHGDL 165

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 110625726 245 LIMEGATQADWQHRVPKEYHSRQPRVNLTFRTVYP 279
Cdd:COG3145  166 LVMGGPTQLAWQHGVPKTKKGTGPRINLTFRRIGP 200
2OG-FeII_Oxy_2 pfam13532
2OG-Fe(II) oxygenase superfamily;
90-275 1.03e-29

2OG-Fe(II) oxygenase superfamily;


Pssm-ID: 433285  Cd Length: 191  Bit Score: 110.87  E-value: 1.03e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625726   90 VCLYPGFVDLKEADWILEQLCKDVPWKQ---RMGIREDVTYPQPRLTAWYGELP-YTYSR---ITMEPNPHWLPVLWTLK 162
Cdd:pfam13532   2 LVLLPGFLSPEEAAELLRELLEEGPFRQpttQGGRPMSVRMTNCGQLGWVTDGPgYRYSGvdpVTGEPWPPFPEALLQLA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110625726  163 SRIEENT---SHTFNSLLCNFYRDeKDSVDWHSD-DEPSLGSCpvIASLSFGATRTFEMRKKPPPEengdytyvERVKIP 238
Cdd:pfam13532  82 ERLAAEAgypGWSPNACLVNFYRD-GARMGLHQDrDESGPGAP--IVSLSLGASATFRFGGKSRSD--------PTISLR 150

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 110625726  239 LDHGTLLIMEGATQADWqHRVPKEYHSRQP-----RVNLTFR 275
Cdd:pfam13532 151 LESGDVLVMGGESRLAY-HGVPPIRRGTHPllgggRINLTFR 191
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH