NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|51243047|ref|NP_081642|]
View 

lymphocyte antigen 6G6e isoform a precursor [Mus musculus]

Protein Classification

Activin_recp domain-containing protein( domain architecture ID 10471049)

Activin_recp domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TFP_LU_ECD_Ly6G6e cd23548
extracellular domain (ECD) found in lymphocyte antigen 6 complex locus protein G6e (Ly6G6e) ...
 26-104 1.17e-49

extracellular domain (ECD) found in lymphocyte antigen 6 complex locus protein G6e (Ly6G6e) and similar proteins; Ly6G6e (also called lymphocyte antigen 6G6e) is a glycosylated, GPI-anchored, cell surface molecule, located on filopodia, which could act as cell receptor with potential roles in signaling or cell-cell interactions. It may act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro it potentiates alpha-3:beta-4-containing nAChRs maximum response by increasing peak current and slowing down receptor desensitization; the activity is dependent on its cell surface localization. Ly6G6e contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


:

Pssm-ID: 467078  Cd Length: 78  Bit Score: 153.24  E-value: 1.17e-49
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 51243047  26 GRLRCYTCSFAKPCDPVPRECREDEVCGVSVGTSEQKEEeVIERKGCLPRAQCPLLGHATYWSRSYSLRHQCCEQDLCN 104
Cdd:cd23548   1 GRLRCYTCSFAKPCYPVPTECREDEVCGVSVGTSEQSEE-VIERKGCLPRAQCPLLGHATYWSRSYTLRHQCCEQDLCN 78
 
Name Accession Description Interval E-value
TFP_LU_ECD_Ly6G6e cd23548
extracellular domain (ECD) found in lymphocyte antigen 6 complex locus protein G6e (Ly6G6e) ...
 26-104 1.17e-49

extracellular domain (ECD) found in lymphocyte antigen 6 complex locus protein G6e (Ly6G6e) and similar proteins; Ly6G6e (also called lymphocyte antigen 6G6e) is a glycosylated, GPI-anchored, cell surface molecule, located on filopodia, which could act as cell receptor with potential roles in signaling or cell-cell interactions. It may act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro it potentiates alpha-3:beta-4-containing nAChRs maximum response by increasing peak current and slowing down receptor desensitization; the activity is dependent on its cell surface localization. Ly6G6e contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467078  Cd Length: 78  Bit Score: 153.24  E-value: 1.17e-49
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 51243047  26 GRLRCYTCSFAKPCDPVPRECREDEVCGVSVGTSEQKEEeVIERKGCLPRAQCPLLGHATYWSRSYSLRHQCCEQDLCN 104
Cdd:cd23548   1 GRLRCYTCSFAKPCYPVPTECREDEVCGVSVGTSEQSEE-VIERKGCLPRAQCPLLGHATYWSRSYTLRHQCCEQDLCN 78
Activin_recp pfam01064
Activin types I and II receptor domain; This Pfam entry consists of both TGF-beta receptor ...
 28-105 1.07e-08

Activin types I and II receptor domain; This Pfam entry consists of both TGF-beta receptor types. This is an alignment of the hydrophilic cysteine-rich ligand-binding domains, Both receptor types, (type I and II) posses a 9 amino acid cysteine box, with the the consensus CCX{4-5}CN. The type I receptors also possess 7 extracellular residues preceding the cysteine box.


Pssm-ID: 460048  Cd Length: 78  Bit Score: 48.65  E-value: 1.07e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51243047    28 LRCYtcsfakpCDPVprECREDEVCGVSVGTS--------EQKEEEVIERKGCLPRAQCPLLGHATYWSRSYSlRHQCCE 99
Cdd:pfam01064   1 LKCY-------CNPL--KCNDDNVNFTCETDGqcfsswelDTDGFIECVKKGCLSPEDDPFECKTSNKPHSLY-RIECCK 70


                  ....*.
gi 51243047   100 QDLCNA 105
Cdd:pfam01064  71 TDFCNK 76
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 28-108 4.87e-06

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 42.14  E-value: 4.87e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51243047     28 LRCYTC--SFAKPCdPVPRECRE-DEVCGVSVGTSEQKEEEVIERKGCLPRAQCPLLGHATYWSRSYSLRHQCCEQDLCN 104
Cdd:smart00134   1 LQCYSCtgNPDSSC-SSEEECRSpDDVCLTVVAEVISDSRGSVVYKGCATSPICPGSHGYEINLTIAFLKVSCCQTDLCN 79


                   ....
gi 51243047    105 AAAS 108
Cdd:smart00134  80 AAGP 83
 
Name Accession Description Interval E-value
TFP_LU_ECD_Ly6G6e cd23548
extracellular domain (ECD) found in lymphocyte antigen 6 complex locus protein G6e (Ly6G6e) ...
 26-104 1.17e-49

extracellular domain (ECD) found in lymphocyte antigen 6 complex locus protein G6e (Ly6G6e) and similar proteins; Ly6G6e (also called lymphocyte antigen 6G6e) is a glycosylated, GPI-anchored, cell surface molecule, located on filopodia, which could act as cell receptor with potential roles in signaling or cell-cell interactions. It may act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro it potentiates alpha-3:beta-4-containing nAChRs maximum response by increasing peak current and slowing down receptor desensitization; the activity is dependent on its cell surface localization. Ly6G6e contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467078  Cd Length: 78  Bit Score: 153.24  E-value: 1.17e-49
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 51243047  26 GRLRCYTCSFAKPCDPVPRECREDEVCGVSVGTSEQKEEeVIERKGCLPRAQCPLLGHATYWSRSYSLRHQCCEQDLCN 104
Cdd:cd23548   1 GRLRCYTCSFAKPCYPVPTECREDEVCGVSVGTSEQSEE-VIERKGCLPRAQCPLLGHATYWSRSYTLRHQCCEQDLCN 78
Activin_recp pfam01064
Activin types I and II receptor domain; This Pfam entry consists of both TGF-beta receptor ...
 28-105 1.07e-08

Activin types I and II receptor domain; This Pfam entry consists of both TGF-beta receptor types. This is an alignment of the hydrophilic cysteine-rich ligand-binding domains, Both receptor types, (type I and II) posses a 9 amino acid cysteine box, with the the consensus CCX{4-5}CN. The type I receptors also possess 7 extracellular residues preceding the cysteine box.


Pssm-ID: 460048  Cd Length: 78  Bit Score: 48.65  E-value: 1.07e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51243047    28 LRCYtcsfakpCDPVprECREDEVCGVSVGTS--------EQKEEEVIERKGCLPRAQCPLLGHATYWSRSYSlRHQCCE 99
Cdd:pfam01064   1 LKCY-------CNPL--KCNDDNVNFTCETDGqcfsswelDTDGFIECVKKGCLSPEDDPFECKTSNKPHSLY-RIECCK 70


                  ....*.
gi 51243047   100 QDLCNA 105
Cdd:pfam01064  71 TDFCNK 76
TFP_LU_ECD_Bncr cd23597
extracellular domain (ECD) found in Danio rerio protein Bouncer and similar proteins; Bouncer ...
 28-104 6.80e-08

extracellular domain (ECD) found in Danio rerio protein Bouncer and similar proteins; Bouncer (bncr) is an oocyte-expressed fertilization factor that mediates sperm-egg binding and is essential for sperm entry into the egg. It is necessary and sufficient to mediate species-specific gamete recognition and fertilization, which is essential for vertebrate species performing external fertilization. Bouncer contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467126  Cd Length: 78  Bit Score: 46.49  E-value: 6.80e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51243047  28 LRCYTC---SFAKPCDPVPRECREDEVCGVSVGtsEQKEEEVIERKGCLPRAQCPLLGHATYWSRSYSLRHQCCEQDLCN 104
Cdd:cd23597   1 LLCLYCplqEKEKTCTNVTTECPPQERCFSARG--RYGGYHVLSAQGCMARELCGSVHSVSYRGINYNVTYSCCCWDYCN 78
TFP_LU_ECD_SPACA4 cd23574
extracellular domain (ECD) found in sperm acrosome membrane-associated protein 4 (SPACA4); ...
 28-104 1.19e-06

extracellular domain (ECD) found in sperm acrosome membrane-associated protein 4 (SPACA4); SPACA4 (also called SAMP14) is a sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. SPACA4 contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467104  Cd Length: 79  Bit Score: 43.52  E-value: 1.19e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 51243047  28 LRCYTCSFAKP--CDPVPRECREDEVCGVSVGTSeqKEEEVIERKGCLPRAQCPLLGHATYWSRSYSLRHQCCEQDLCN 104
Cdd:cd23574   3 KTCYYCDLTNSsdCPGIPMICADEEDCYTGRGAA--LGFPLIINKGCIEATRCGKEESVTYMGVTYNLTTYCCEGELCN 79
TFP cd00117
three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU ...
 28-104 1.56e-06

three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU (also known as Ly-6 antigen/uPA receptor)-like extracellular domain (ECD) occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. It is a structural domain involved in protein-protein interactions, tolerating an unusual degree of variation and binding with high specificity to a broad spectrum of targets. The snake toxin domain is present in short and long neurotoxins, cytotoxins, and short toxins, and in other miscellaneous venom peptides. The toxin acts by binding to the nicotinic acetylcholine receptors in the postsynaptic membrane of skeletal muscles and preventing the binding of acetylcholine, thereby blocking the excitation of muscles. Both the LU-like ECD and the snake toxin domain belong to three-fingered protein (TFP) fold, which is characterized by containing 70 to 100 amino acids including eight to ten cysteine residues spaced at conserved distances.


Pssm-ID: 467060  Cd Length: 81  Bit Score: 43.24  E-value: 1.56e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51243047  28 LRCYTCSFAKPCD-----PVPRECREDE-VCGVSVGTSEQKEEEVIerKGCLPRAQCPLLGHATYWSRSYSLRHQCCEQD 101
Cdd:cd00117   1 LKCYQCNSSNDPNccnssPTLVTCSSPEtFCRKIVGKVGGGETLVI--RGCATECECGCTECCSGTGTSGTTCTSCCDTD 78


                ...
gi 51243047 102 LCN 104
Cdd:cd00117  79 LCN 81
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 28-108 4.87e-06

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 42.14  E-value: 4.87e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51243047     28 LRCYTC--SFAKPCdPVPRECRE-DEVCGVSVGTSEQKEEEVIERKGCLPRAQCPLLGHATYWSRSYSLRHQCCEQDLCN 104
Cdd:smart00134   1 LQCYSCtgNPDSSC-SSEEECRSpDDVCLTVVAEVISDSRGSVVYKGCATSPICPGSHGYEINLTIAFLKVSCCQTDLCN 79


                   ....
gi 51243047    105 AAAS 108
Cdd:smart00134  80 AAGP 83
TFP_LU_ECD_Ly6L cd23551
extracellular domain (ECD) found in lymphocyte antigen 6L (Ly-6L) and similar proteins; Ly-6L ...
 27-107 8.29e-03

extracellular domain (ECD) found in lymphocyte antigen 6L (Ly-6L) and similar proteins; Ly-6L (also called lymphocyte antigen 6 complex locus protein L) contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467081  Cd Length: 86  Bit Score: 33.53  E-value: 8.29e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51243047  27 RLRCYTC---SFAKPCDPVprECREDEVCGVS--VGTSEQKEEEVIERKGCLPRaqCPLLGHATYWSRSY----SLRHQC 97
Cdd:cd23551   1 NLKCYQCfkvSSDEDCKPD--QCAPSEIVCISneVVLYVGTKVRVLISKRCAPR--CPNTNSRCEWSPGTqvigSITRTC 76

                        90
                ....*....|
gi 51243047  98 CEQDLCNAAA 107
Cdd:cd23551  77 CSQSLCNRAP 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH