NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1409931530|ref|NP_082106|]
View 

DNA helicase MCM9 [Mus musculus]

Protein Classification

ATP-binding protein; minichromosome maintenance protein MCM; minichromosome maintenance protein MCM; minichromosome maintenance protein; ATP-binding protein; minichromosome maintenance protein MCM; minichromosome maintenance protein MCM; minichromosome maintenance protein; minichromosome maintenance protein MCM; ATP-binding protein; minichromosome maintenance protein MCM; minichromosome maintenance protein MCM; minichromosome maintenance protein; ATP-binding protein; minichromosome maintenance protein MCM; minichromosome maintenance protein MCM; minichromosome maintenance protein; minichromosome maintenance protein MCM; minichromosome maintenance protein; minichromosome maintenance protein MCM( domain architecture ID 13599676)

ATP-binding protein with an AAA (ATPases Associated with various cellular Activities) domain, similar to magnesium-chelatase subunit ChlI and RuvB-like helicase 1; minichromosome maintenance protein is MCM is one of the highly conserved MCM complex proteins; the complex may have helicase activity and is essential for the initiation of DNA replication; minichromosome maintenance protein is MCM is one of the highly conserved MCM complex proteins; the complex may have helicase activity and is essential for the initiation of DNA replication; minichromosome maintenance protein (MCM) is a DNA-dependent ATPase required for the initiation of eukaryotic DNA replication; similar to DNA helicase MCM9, a component of the MCM8-MCM9 complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR); ATP-binding protein with an AAA (ATPases Associated with various cellular Activities) domain, similar to magnesium-chelatase subunit ChlI and RuvB-like helicase 1; minichromosome maintenance protein is MCM is one of the highly conserved MCM complex proteins; the complex may have helicase activity and is essential for the initiation of DNA replication; minichromosome maintenance protein is MCM is one of the highly conserved MCM complex proteins; the complex may have helicase activity and is essential for the initiation of DNA replication; minichromosome maintenance protein (MCM) is a DNA-dependent ATPase required for the initiation of eukaryotic DNA replication; similar to DNA helicase MCM9, a component of the MCM8-MCM9 complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR); minichromosome maintenance protein is MCM is one of the highly conserved MCM complex proteins; the complex may have helicase activity and is essential for the initiation of DNA replication; ATP-binding protein with an AAA (ATPases Associated with various cellular Activities) domain, similar to magnesium-chelatase subunit ChlI and RuvB-like helicase 1; minichromosome maintenance protein is MCM is one of the highly conserved MCM complex proteins; the complex may have helicase activity and is essential for the initiation of DNA replication; minichromosome maintenance protein is MCM is one of the highly conserved MCM complex proteins; the complex may have helicase activity and is essential for the initiation of DNA replication; minichromosome maintenance protein (MCM) is a DNA-dependent ATPase required for the initiation of eukaryotic DNA replication; similar to DNA helicase MCM9, a component of the MCM8-MCM9 complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR); ATP-binding protein with an AAA (ATPases Associated with various cellular Activities) domain, similar to magnesium-chelatase subunit ChlI and RuvB-like helicase 1; minichromosome maintenance protein is MCM is one of the highly conserved MCM complex proteins; the complex may have helicase activity and is essential for the initiation of DNA replication; minichromosome maintenance protein is MCM is one of the highly conserved MCM complex proteins; the complex may have helicase activity and is essential for the initiation of DNA replication; minichromosome maintenance protein (MCM) is a DNA-dependent ATPase required for the initiation of eukaryotic DNA replication; similar to DNA helicase MCM9, a component of the MCM8-MCM9 complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR); minichromosome maintenance protein is MCM is one of the highly conserved MCM complex proteins; the complex may have helicase activity and is essential for the initiation of DNA replication; minichromosome maintenance protein (MCM) is a DNA-dependent ATPase required for the initiation of eukaryotic DNA replication; similar to DNA helicase MCM9, a component of the MCM8-MCM9 complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR); minichromosome maintenance protein is MCM is one of the highly conserved MCM complex proteins; the complex may have helicase activity and is essential for the initiation of DNA replication

EC:  3.6.4.12
Gene Ontology:  GO:0032508|GO:0003677|GO:0005524
PubMed:  15007098

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MCM9 cd17760
DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a ...
 305-603 0e+00

DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a complex with Mcm8 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


:

Pssm-ID: 350666 [Multi-domain]  Cd Length: 299  Bit Score: 592.98  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  305 EILASLCPQVFGMYLVKLAVAMVLAGGIQRTDAAGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAG 384
Cdd:cd17760      1 EILASLCPQVFGLYNVKLAVAMVLAGGVQRIDASGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTAGIGSTSAG 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  385 LTVTAVKDSGEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPKGQYD 464
Cdd:cd17760     81 LTVTAVKDGGEWNLEAGALVLADGGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPKGQYD 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  465 PKESVSVNIALGSPLLSRFDLVLVLLDTRNEDWDRIISSFILENKGYPSKSENLWSMEKMKTYFCLIRNLHPTLSEVSNQ 544
Cdd:cd17760    161 PNESISVNIALASPLLSRFDLVLVLLDTKNEDWDRIISSFILENKGEPSKSSKLWSMEKMRTYFCLIKNLRPVLSDEANA 240

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1409931530  545 VLLRYYQMQRQSDSRNAARTTIRLLESLIRLAEAHARLMFRSAVTLEDAVTAVSVMESS 603
Cdd:cd17760    241 ILLRYYQLQRQSDCRNAARTTIRMLESLIRLAEAHARLMFRETVTEEDAITVVSVMESS 299
MCM_OB super family cl38516
MCM OB domain; This family contains an OB-fold found within MCM proteins. This domain contains ...
 116-243 2.41e-24

MCM OB domain; This family contains an OB-fold found within MCM proteins. This domain contains an insertion at the zinc binding motif.


The actual alignment was detected with superfamily member pfam17207:

Pssm-ID: 465381 [Multi-domain]  Cd Length: 126  Bit Score: 99.09  E-value: 2.41e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  116 KTKDVGHFLSVTGTVIRTSLVK---VLEFerdYMCNKCKHVFMVEadfeqyytFSRPSSCPSlASCDS-SKFSCLSDLSs 191
Cdd:pfam17207    6 RSEHIGKLVSVSGIVTRTSEVRpklKKAT---FTCRKCGHTVGVK--------ITEPTKCPN-PECGNkDPFKLVHEKS- 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1409931530  192 spaRCRDYQEIKIQEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYGV 243
Cdd:pfam17207   73 ---KFVDFQKIKIQESPEEVPAGELPRSLDVILDDDLVDRVKPGDRVTVTGI 121
PTZ00449 super family cl33186
104 kDa microneme/rhoptry antigen; Provisional
 739-1004 3.70e-05

104 kDa microneme/rhoptry antigen; Provisional


The actual alignment was detected with superfamily member PTZ00449:

Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 48.15  E-value: 3.70e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  739 DPTSSPEIAPESTIVSPnvktteknvnlKISNNKSQGKEKHGPQQRSKLLEAGHLPSSGAMNAPLRSHG-VKRTKASQAV 817
Cdd:PTZ00449   505 DKHDEPPEGPEASGLPP-----------KAPGDKEGEEGEHEDSKESDEPKEGGKPGETKEGEVGKKPGpAKEHKPSKIP 573

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  818 VVSEAGRGDEEDSVPRRlPKLLKEGSQNVCRSTTrVRPLPPTVPLSLSIPSpgSGKRSGTPKRKRRKSAQVEEPEPEGME 897
Cdd:PTZ00449   574 TLSKKPEFPKDPKHPKD-PEEPKKPKRPRSAQRP-TRPKSPKLPELLDIPK--SPKRPESPKSPKRPPPPQRPSSPERPE 649

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  898 TPtvKLAKftfkqKTKLTHSPegQGPIPPSASEIAVDSSKIPQQRTRReaAVPVVAPGKSTSTSGDRCSDQLHGKTKELS 977
Cdd:PTZ00449   650 GP--KIIK-----SPKPPKSP--KPPFDPKFKEKFYDDYLDAAAKSKE--TKTTVVLDESFESILKETLPETPGTPFTTP 718

                          250       260
                   ....*....|....*....|....*..
gi 1409931530  978 RQPPDSNPPREEREQGPKRRVIQPKPE 1004
Cdd:PTZ00449   719 RPLPPKLPRDEEFPFEPIGDPDAEQPD 745
 
Name Accession Description Interval E-value
MCM9 cd17760
DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a ...
 305-603 0e+00

DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a complex with Mcm8 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350666 [Multi-domain]  Cd Length: 299  Bit Score: 592.98  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  305 EILASLCPQVFGMYLVKLAVAMVLAGGIQRTDAAGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAG 384
Cdd:cd17760      1 EILASLCPQVFGLYNVKLAVAMVLAGGVQRIDASGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTAGIGSTSAG 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  385 LTVTAVKDSGEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPKGQYD 464
Cdd:cd17760     81 LTVTAVKDGGEWNLEAGALVLADGGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPKGQYD 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  465 PKESVSVNIALGSPLLSRFDLVLVLLDTRNEDWDRIISSFILENKGYPSKSENLWSMEKMKTYFCLIRNLHPTLSEVSNQ 544
Cdd:cd17760    161 PNESISVNIALASPLLSRFDLVLVLLDTKNEDWDRIISSFILENKGEPSKSSKLWSMEKMRTYFCLIKNLRPVLSDEANA 240

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1409931530  545 VLLRYYQMQRQSDSRNAARTTIRLLESLIRLAEAHARLMFRSAVTLEDAVTAVSVMESS 603
Cdd:cd17760    241 ILLRYYQLQRQSDCRNAARTTIRMLESLIRLAEAHARLMFRETVTEEDAITVVSVMESS 299
Mcm2 COG1241
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ...
 13-605 7.85e-149

DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];


Pssm-ID: 440854 [Multi-domain]  Cd Length: 682  Bit Score: 461.96  E-value: 7.85e-149
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530   13 FESYVSEY-HKNDILLILkerdedAHYP----VVVNAMSLFETNMEIGDYFTVFPNEVLTVFDSALRrsaLAILQSLPET 87
Cdd:COG1241      9 FEEFLRRYkYRDEILELA------QEYPekrsLVVDYNDLYSFDPDLADDLLENPDEVLEAAEEALR---EIDLEPYDVS 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530   88 EGlsmkqNLHARISGLPVCPELvrEHIPkTKDVGHFLSVTGTVIRTSLVKVLEFERDYMCNKCKHVFMVEADFEQyytFS 167
Cdd:COG1241     80 LG-----DAHVRITNLPETVPI--RDIR-SDHIGKLISVEGIVRKATEVKPKITEAAFECPRCGTETYVPQTGEK---LQ 148

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  168 RPSSCPSlasCDSS-KFSCLSDLSsspaRCRDYQEIKIQEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYGVVMQ 246
Cdd:COG1241    149 EPHECPG---CGRQgPFKLLPEKS----EFIDAQKIRIQEPPEDLPGGQQPQSIDVILEDDLVGEVRPGDRVTVTGILRI 221

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  247 RWKPFQRDVRCEVEIVLKANYVQVNNEQSSGMVMDEDTRKEFEDFwehyKSDPFAgRNEILASLCPQVFGMYLVKLAVAM 326
Cdd:COG1241    222 EQRTSGRGKSTIFDLYLEANSIEVEEKEFEEIEITEEDEEKIKEL----SKDPDI-YEKIIASIAPSIYGYEEIKEAIAL 296

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  327 VLAGGIQRTDAAGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGLTVTAVKD---SGEWNLEAGAL 403
Cdd:COG1241    297 QLFGGVPKVLPDGSRIRGDIHILLVGDPGTAKSQLLRYAARLAPRGVYTSGKGSTAAGLTAAAVRDdfgTGRWTLEAGAL 376

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  404 VLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPK-GQYDPKESVSVNIALGSPLLSR 482
Cdd:COG1241    377 VLADGGLACIDELDKMREEDRSALHEAMEQQTISIAKAGIVATLNARCSVLAAANPKyGRFDPYEPIAEQIDLPPTLLSR 456

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  483 FDLVLVLLDTRNEDWDRIISSFILEN--KGYPSKSENLWSMEKMKTYfclI-------------RNLHPTLSEVSNQVLL 547
Cdd:COG1241    457 FDLIFVLRDKPDEERDRELARHILKVhrAGELLEQEIEEETEEVKPE---IdpdllrkyiayarRNVFPVLTEEAKDLIE 533

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  548 RYY-QMQRQSDSRNAART-TIRLLESLIRLAEAHARLMFRSAVTLEDAVTAVSVMESSMQ 605
Cdd:COG1241    534 DFYvDMRKKGEDEDSPVPiTARQLEALIRLAEASARMRLSDTVTEEDAERAIRLVDSCLK 593
minchrom_main_MCM NF040949
minichromosome maintenance protein MCM;
9-605 2.48e-145

minichromosome maintenance protein MCM;


Pssm-ID: 468880 [Multi-domain]  Cd Length: 681  Bit Score: 452.46  E-value: 2.48e-145
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530    9 VGQVFESYVSEYHKNDILLILKERDED--AHYP--VVVNAMSLFETNMEIGDYFTVFPNEVLTVFDSALRRsalAILQSL 84
Cdd:NF040949     1 LGEKFKEFIRTFRDSFGNEKYKERIFEmiAMRKrsLVVDFNDLYMFDPELADLLIEKPDEVLPAASKALKE---IVEEED 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530   85 PETEGLsmKQNLHARISGLPvcpELVREHIPKTKDVGHFLSVTGTVIRTSLVKVLEFERDYMCNKCKHVFMVEADFEQYY 164
Cdd:NF040949    78 PEYAEE--VAKFHVRFRNLP---RTVPLRDLRSEYIGKLIAVEGIVTRTTPVKPRIVKAVFRCRDCGCEFEWPEEEEESY 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  165 TFS-RPSSCPSlasCDSS-KFSCLSDLSsspaRCRDYQEIKIQEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYG 242
Cdd:NF040949   153 EIVePPTVCPV---CGKPgSFRLLQEKS----KFIDWQKIVVQERPEELPPGQLPRSIEVVLEDDLVDTARPGDRVTVTG 225

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  243 VV-MQRWKPFQRDVRCEVEIVLKANYVQVNNEqssgmVMDED--TRKEFEDFWEHYKsDPFAgRNEILASLCPQVFGMYL 319
Cdd:NF040949   226 ILrIKPDSSLKKGSRPIFKNYIEANHIEVSQK-----ELEEVeiTEEDEEKILELAK-DPWI-REKIIASIAPSIYGHWE 298

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  320 VKLAVAMVLAGGIQRTDAAGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGLTVTAVKD--SGEWN 397
Cdd:NF040949   299 IKEAIALLLFGGVPKVLPDGTRIRGDIHVLIVGDPGTAKSQLLQYVARLAPRAVYTSGKGSTAAGLTAAVVRDklTGEYY 378

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  398 LEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPK-GQYDPKESVSVNIALG 476
Cdd:NF040949   379 LEAGALVLADGGVAVIDEIDKMREEDRSAIHEAMEQQTVSIAKAGIVATLNARASVLAAGNPKfGRYDPNRSVAENIDLP 458

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  477 SPLLSRFDLVLVLLDTRNEDWDRIISSFILENKGYPSKSENLWSMEKMKTYFCLIR-NLHPTLSEVSNQVLLRYY-QMQR 554
Cdd:NF040949   459 PTILSRFDLIFVIRDKPNEERDRRLARHILDVHSGKEKVKPEIDPDLLKKYIAYARkYVRPKLTEEAKKLIEDFYvEMRK 538

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1409931530  555 QSDSRNAART----TIRLLESLIRLAEAHARLMFRSAVTLEDAVTAVSVMESSMQ 605
Cdd:NF040949   539 SSKSSEDPDSpipiTARQLEALIRLSEAHAKMRLKDEVTAEDAERAIRLMLAFLE 593
MCM smart00350
minichromosome maintenance proteins;
116-603 5.87e-137

minichromosome maintenance proteins;


Pssm-ID: 214631 [Multi-domain]  Cd Length: 509  Bit Score: 424.37  E-value: 5.87e-137
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530   116 KTKDVGHFLSVTGTVIRTSLVKVLEFERDYMCNKCKHVFmveADFEQYYTFSRPSSCPSLASCDSSKFSCLSDLSsspaR 195
Cdd:smart00350    9 RADHLGKLVRISGIVTRTSGVRPKLKRASFTCEKCGATL---GPEIQSGRETEPTVCPPRECQSPTPFSLNHERS----T 81

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530   196 CRDYQEIKIQEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYGVVmqRWKPFQRDV-----RCEVEIVLKANYVQV 270
Cdd:smart00350   82 FIDFQKIKLQESPEEVPVGQLPRSVDVILDGDLVDKAKPGDRVEVTGIY--RNVPYGFKLntvkgLPVFATYIEANHVRK 159

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530   271 NNEQSSGMVMDEDTRK----EFEDFWEHYKSDPFAgrNEILASLCPQVFGMYLVKLAVAMVLAGGIQRTDAAGTRVRGES 346
Cdd:smart00350  160 LDYKRSFEDSSFSVQSlsdeEEEEIRKLSKDPDIY--ERLARSLAPSIYGHEDIKKAILLLLFGGVHKNLPDGMKIRGDI 237

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530   347 HLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGLTVTAVKD--SGEWNLEAGALVLADAGLCCIDEFNSLKEHDR 424
Cdd:smart00350  238 NILLCGDPGTAKSQLLKYVEKTAPRAVYTTGKGSSAVGLTAAVTRDpeTREFTLEAGALVLADNGVCCIDEFDKMDDSDR 317

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530   425 TSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNP-KGQYDPKESVSVNIALGSPLLSRFDLVLVLLDTRNEDWDRIISS 503
Cdd:smart00350  318 TAIHEAMEQQTISIAKAGITTTLNARCSVLAAANPiGGRYDPKLTPEENIDLPAPILSRFDLLFVVLDEVDEERDRELAK 397

                           410       420       430       440       450       460       470       480
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530   504 FILENKGY-----PSKSENLWSMEKMKTYFCLIR-NLHPTLSEVSNQVLLRYY----QMQRQSDSRNAARTTIRLLESLI 573
Cdd:smart00350  398 HVVDLHRYshpeeDEAFEPPLSQEKLRKYIAYAReKIKPKLSEEAADKLVKAYvdlrKEDSQTESRSSIPITVRQLESII 477

                           490       500       510
                    ....*....|....*....|....*....|
gi 1409931530   574 RLAEAHARLMFRSAVTLEDAVTAVSVMESS 603
Cdd:smart00350  478 RLSEAHAKMRLSDVVEEADVEEAIRLLRES 507
MCM pfam00493
MCM P-loop domain;
305-508 3.62e-99

MCM P-loop domain;


Pssm-ID: 459830 [Multi-domain]  Cd Length: 224  Bit Score: 313.31  E-value: 3.62e-99
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  305 EILA-SLCPQVFGMYLVKLAVAMVLAGGIQRTDAAGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSA 383
Cdd:pfam00493   16 DKLAdSIAPSIYGHEDVKKAILLQLFGGVKKILPDGTRLRGDINVLLVGDPGTAKSQLLKYVEKIAPRAVYTSGKGSSAA 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  384 GLTVTAVKD--SGEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPK- 460
Cdd:pfam00493   96 GLTAAVVRDpvTGEFVLEAGALVLADGGVCCIDEFDKMNDEDRVALHEAMEQQTISIAKAGIVATLNARCSILAAANPIf 175

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 1409931530  461 GQYDPKESVSVNIALGSPLLSRFDLVLVLLDTRNEDWDRIISSFILEN 508
Cdd:pfam00493  176 GRYDPKKSIAENINLPPPLLSRFDLIFVLLDKPDEEKDERLAKHIVDL 223
PTZ00111 PTZ00111
DNA replication licensing factor MCM4; Provisional
 218-603 4.22e-57

DNA replication licensing factor MCM4; Provisional


Pssm-ID: 173403 [Multi-domain]  Cd Length: 915  Bit Score: 214.09  E-value: 4.22e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  218 RSMKVILEDDLVDSCKSGDDLTIYGVVMQ---RWKPFQRDVRCEVEIVLKANYVQVNNEQSSGMVMDE----DTRKEFED 290
Cdd:PTZ00111   346 EVINLNLYDDLIDSVKTGDRVTVVGILKVtpiRTSTTRRTLKSLYTYFVNVIHVKVINSTNANQPEKGlkylGNENDFSD 425

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  291 FwEHYK-----SDPFAGRnEILASLCPQVFGMYLVKLAVAMVLAGGIQRTDAAGTRV---------RGESHLLLVGDPGT 356
Cdd:PTZ00111   426 L-QVYKilelsRNPMIYR-ILLDSFAPSIKARNNVKIGLLCQLFSGNKNSSDFNKSPdacykvdnfRGIINVLLCGDPGT 503

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  357 GKSQFLKYAAKITPRSVLTTGIGSTSAGLTVT-AVKDS--GEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQ 433
Cdd:PTZ00111   504 AKSQLLHYTHLLSPRSIYTSGKSSSSVGLTASiKFNESdnGRAMIQPGAVVLANGGVCCIDELDKCHNESRLSLYEVMEQ 583

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  434 QTISVAKAGLVCKLNTRTTILAATNP-KGQYDPKESVSVNIALGSPLLSRFDLVLVLLDTRNEDWDRIISSFILENKGYP 512
Cdd:PTZ00111   584 QTVTIAKAGIVATLKAETAILASCNPiNSRYNKNKAVIENINISPSLFTRFDLIYLVLDHIDQDTDQLISLSIAKDFLLP 663

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  513 S---------------------------KSENLWSMEKMKTY--FCLIrNLHPTLSEVSNQVLLRYYQMQRQSDSRNAAR 563
Cdd:PTZ00111   664 HmtgsgndedtydrsntmhvedeslrseKDYNKNDLDMLRMYikFSKL-HCFPKLSDEAKKVITREYVKMRQGNFQTSNL 742

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1409931530  564 TTI-------------------------RLLESLIRLAEAHARLMFRSAVTLEDAVTAVSVMESS 603
Cdd:PTZ00111   743 DELehaqedddddlyyqssgtrmiyvssRMISSIIRISVSLARMRLSTVVTPADALQAVQIVKSS 807
MCM_OB pfam17207
MCM OB domain; This family contains an OB-fold found within MCM proteins. This domain contains ...
 116-243 2.41e-24

MCM OB domain; This family contains an OB-fold found within MCM proteins. This domain contains an insertion at the zinc binding motif.


Pssm-ID: 465381 [Multi-domain]  Cd Length: 126  Bit Score: 99.09  E-value: 2.41e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  116 KTKDVGHFLSVTGTVIRTSLVK---VLEFerdYMCNKCKHVFMVEadfeqyytFSRPSSCPSlASCDS-SKFSCLSDLSs 191
Cdd:pfam17207    6 RSEHIGKLVSVSGIVTRTSEVRpklKKAT---FTCRKCGHTVGVK--------ITEPTKCPN-PECGNkDPFKLVHEKS- 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1409931530  192 spaRCRDYQEIKIQEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYGV 243
Cdd:pfam17207   73 ---KFVDFQKIKIQESPEEVPAGELPRSLDVILDDDLVDRVKPGDRVTVTGI 121
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 739-1004 3.70e-05

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 48.15  E-value: 3.70e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  739 DPTSSPEIAPESTIVSPnvktteknvnlKISNNKSQGKEKHGPQQRSKLLEAGHLPSSGAMNAPLRSHG-VKRTKASQAV 817
Cdd:PTZ00449   505 DKHDEPPEGPEASGLPP-----------KAPGDKEGEEGEHEDSKESDEPKEGGKPGETKEGEVGKKPGpAKEHKPSKIP 573

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  818 VVSEAGRGDEEDSVPRRlPKLLKEGSQNVCRSTTrVRPLPPTVPLSLSIPSpgSGKRSGTPKRKRRKSAQVEEPEPEGME 897
Cdd:PTZ00449   574 TLSKKPEFPKDPKHPKD-PEEPKKPKRPRSAQRP-TRPKSPKLPELLDIPK--SPKRPESPKSPKRPPPPQRPSSPERPE 649

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  898 TPtvKLAKftfkqKTKLTHSPegQGPIPPSASEIAVDSSKIPQQRTRReaAVPVVAPGKSTSTSGDRCSDQLHGKTKELS 977
Cdd:PTZ00449   650 GP--KIIK-----SPKPPKSP--KPPFDPKFKEKFYDDYLDAAAKSKE--TKTTVVLDESFESILKETLPETPGTPFTTP 718

                          250       260
                   ....*....|....*....|....*..
gi 1409931530  978 RQPPDSNPPREEREQGPKRRVIQPKPE 1004
Cdd:PTZ00449   719 RPLPPKLPRDEEFPFEPIGDPDAEQPD 745
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 700-1004 1.83e-04

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 45.53  E-value: 1.83e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  700 SSTERSGADSPP-GPGLNRPTSCNNSAENRDGRGDGLDWLDPTSSPEIAPESTIVSPNVKTTEKNVNLKISNNKSQgKEK 778
Cdd:NF033839   148 SSSSSSGSSTKPeTPQPENPEHQKPTTPAPDTKPSPQPEGKKPSVPDINQEKEKAKLAVATYMSKILDDIQKHHLQ-KEK 226

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  779 H----GPQQRSKLLEAGHLPSSGAMNAPLR-SHGVKRTKASQAVVVSEAGRGDEEDSvprrlPKLLKEGSQNVCRSTTRV 853
Cdd:NF033839   227 HrqivALIKELDELKKQALSEIDNVNTKVEiENTVHKIFADMDAVVTKFKKGLTQDT-----PKEPGNKKPSAPKPGMQP 301

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  854 RPLPPTVPLSLSIPSPGSGKRSGTPKRKRRKSAQVEEPEPE---GMETPTVKLAKFTFKQKTKLTHSPEGQGPIPPSASE 930
Cdd:NF033839   302 SPQPEKKEVKPEPETPKPEVKPQLEKPKPEVKPQPEKPKPEvkpQLETPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPE 381

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1409931530  931 iavdsSKIPQQRTRREAAVPVVAPgkSTSTSGDRCSDQLHGKTKELSRQPpdsNPPREEREQGPKRRVIQPKPE 1004
Cdd:NF033839   382 -----TPKPEVKPQPEKPKPEVKP--QPEKPKPEVKPQPEKPKPEVKPQP---EKPKPEVKPQPEKPKPEVKPQ 445
 
Name Accession Description Interval E-value
MCM9 cd17760
DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a ...
 305-603 0e+00

DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a complex with Mcm8 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350666 [Multi-domain]  Cd Length: 299  Bit Score: 592.98  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  305 EILASLCPQVFGMYLVKLAVAMVLAGGIQRTDAAGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAG 384
Cdd:cd17760      1 EILASLCPQVFGLYNVKLAVAMVLAGGVQRIDASGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTAGIGSTSAG 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  385 LTVTAVKDSGEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPKGQYD 464
Cdd:cd17760     81 LTVTAVKDGGEWNLEAGALVLADGGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPKGQYD 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  465 PKESVSVNIALGSPLLSRFDLVLVLLDTRNEDWDRIISSFILENKGYPSKSENLWSMEKMKTYFCLIRNLHPTLSEVSNQ 544
Cdd:cd17760    161 PNESISVNIALASPLLSRFDLVLVLLDTKNEDWDRIISSFILENKGEPSKSSKLWSMEKMRTYFCLIKNLRPVLSDEANA 240

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1409931530  545 VLLRYYQMQRQSDSRNAARTTIRLLESLIRLAEAHARLMFRSAVTLEDAVTAVSVMESS 603
Cdd:cd17760    241 ILLRYYQLQRQSDCRNAARTTIRMLESLIRLAEAHARLMFRETVTEEDAITVVSVMESS 299
Mcm2 COG1241
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ...
 13-605 7.85e-149

DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];


Pssm-ID: 440854 [Multi-domain]  Cd Length: 682  Bit Score: 461.96  E-value: 7.85e-149
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530   13 FESYVSEY-HKNDILLILkerdedAHYP----VVVNAMSLFETNMEIGDYFTVFPNEVLTVFDSALRrsaLAILQSLPET 87
Cdd:COG1241      9 FEEFLRRYkYRDEILELA------QEYPekrsLVVDYNDLYSFDPDLADDLLENPDEVLEAAEEALR---EIDLEPYDVS 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530   88 EGlsmkqNLHARISGLPVCPELvrEHIPkTKDVGHFLSVTGTVIRTSLVKVLEFERDYMCNKCKHVFMVEADFEQyytFS 167
Cdd:COG1241     80 LG-----DAHVRITNLPETVPI--RDIR-SDHIGKLISVEGIVRKATEVKPKITEAAFECPRCGTETYVPQTGEK---LQ 148

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  168 RPSSCPSlasCDSS-KFSCLSDLSsspaRCRDYQEIKIQEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYGVVMQ 246
Cdd:COG1241    149 EPHECPG---CGRQgPFKLLPEKS----EFIDAQKIRIQEPPEDLPGGQQPQSIDVILEDDLVGEVRPGDRVTVTGILRI 221

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  247 RWKPFQRDVRCEVEIVLKANYVQVNNEQSSGMVMDEDTRKEFEDFwehyKSDPFAgRNEILASLCPQVFGMYLVKLAVAM 326
Cdd:COG1241    222 EQRTSGRGKSTIFDLYLEANSIEVEEKEFEEIEITEEDEEKIKEL----SKDPDI-YEKIIASIAPSIYGYEEIKEAIAL 296

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  327 VLAGGIQRTDAAGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGLTVTAVKD---SGEWNLEAGAL 403
Cdd:COG1241    297 QLFGGVPKVLPDGSRIRGDIHILLVGDPGTAKSQLLRYAARLAPRGVYTSGKGSTAAGLTAAAVRDdfgTGRWTLEAGAL 376

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  404 VLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPK-GQYDPKESVSVNIALGSPLLSR 482
Cdd:COG1241    377 VLADGGLACIDELDKMREEDRSALHEAMEQQTISIAKAGIVATLNARCSVLAAANPKyGRFDPYEPIAEQIDLPPTLLSR 456

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  483 FDLVLVLLDTRNEDWDRIISSFILEN--KGYPSKSENLWSMEKMKTYfclI-------------RNLHPTLSEVSNQVLL 547
Cdd:COG1241    457 FDLIFVLRDKPDEERDRELARHILKVhrAGELLEQEIEEETEEVKPE---IdpdllrkyiayarRNVFPVLTEEAKDLIE 533

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  548 RYY-QMQRQSDSRNAART-TIRLLESLIRLAEAHARLMFRSAVTLEDAVTAVSVMESSMQ 605
Cdd:COG1241    534 DFYvDMRKKGEDEDSPVPiTARQLEALIRLAEASARMRLSDTVTEEDAERAIRLVDSCLK 593
minchrom_main_MCM NF040949
minichromosome maintenance protein MCM;
9-605 2.48e-145

minichromosome maintenance protein MCM;


Pssm-ID: 468880 [Multi-domain]  Cd Length: 681  Bit Score: 452.46  E-value: 2.48e-145
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530    9 VGQVFESYVSEYHKNDILLILKERDED--AHYP--VVVNAMSLFETNMEIGDYFTVFPNEVLTVFDSALRRsalAILQSL 84
Cdd:NF040949     1 LGEKFKEFIRTFRDSFGNEKYKERIFEmiAMRKrsLVVDFNDLYMFDPELADLLIEKPDEVLPAASKALKE---IVEEED 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530   85 PETEGLsmKQNLHARISGLPvcpELVREHIPKTKDVGHFLSVTGTVIRTSLVKVLEFERDYMCNKCKHVFMVEADFEQYY 164
Cdd:NF040949    78 PEYAEE--VAKFHVRFRNLP---RTVPLRDLRSEYIGKLIAVEGIVTRTTPVKPRIVKAVFRCRDCGCEFEWPEEEEESY 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  165 TFS-RPSSCPSlasCDSS-KFSCLSDLSsspaRCRDYQEIKIQEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYG 242
Cdd:NF040949   153 EIVePPTVCPV---CGKPgSFRLLQEKS----KFIDWQKIVVQERPEELPPGQLPRSIEVVLEDDLVDTARPGDRVTVTG 225

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  243 VV-MQRWKPFQRDVRCEVEIVLKANYVQVNNEqssgmVMDED--TRKEFEDFWEHYKsDPFAgRNEILASLCPQVFGMYL 319
Cdd:NF040949   226 ILrIKPDSSLKKGSRPIFKNYIEANHIEVSQK-----ELEEVeiTEEDEEKILELAK-DPWI-REKIIASIAPSIYGHWE 298

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  320 VKLAVAMVLAGGIQRTDAAGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGLTVTAVKD--SGEWN 397
Cdd:NF040949   299 IKEAIALLLFGGVPKVLPDGTRIRGDIHVLIVGDPGTAKSQLLQYVARLAPRAVYTSGKGSTAAGLTAAVVRDklTGEYY 378

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  398 LEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPK-GQYDPKESVSVNIALG 476
Cdd:NF040949   379 LEAGALVLADGGVAVIDEIDKMREEDRSAIHEAMEQQTVSIAKAGIVATLNARASVLAAGNPKfGRYDPNRSVAENIDLP 458

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  477 SPLLSRFDLVLVLLDTRNEDWDRIISSFILENKGYPSKSENLWSMEKMKTYFCLIR-NLHPTLSEVSNQVLLRYY-QMQR 554
Cdd:NF040949   459 PTILSRFDLIFVIRDKPNEERDRRLARHILDVHSGKEKVKPEIDPDLLKKYIAYARkYVRPKLTEEAKKLIEDFYvEMRK 538

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1409931530  555 QSDSRNAART----TIRLLESLIRLAEAHARLMFRSAVTLEDAVTAVSVMESSMQ 605
Cdd:NF040949   539 SSKSSEDPDSpipiTARQLEALIRLSEAHAKMRLKDEVTAEDAERAIRLMLAFLE 593
MCM cd17706
MCM helicase family; MCM helicases are a family of helicases that play an important role in ...
 305-603 2.54e-138

MCM helicase family; MCM helicases are a family of helicases that play an important role in replication and homologous recombination repair. The heterohexameric ring-shaped Mcm2-7 complex is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases. Mcm8 and Mcm9, form a complex required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350658 [Multi-domain]  Cd Length: 311  Bit Score: 420.21  E-value: 2.54e-138
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  305 EILASLCPQVFGMYLVKLAVAMVLAGGIQRTDAAGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAG 384
Cdd:cd17706      1 ILADSIAPSIYGHEDVKKAVLLQLFGGVQKILEDGTRIRGDIHILLVGDPGTAKSQILKYVLKIAPRGVYTSGKGSSGAG 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  385 LTVTAVKDS--GEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPKGQ 462
Cdd:cd17706     81 LTAAVVRDSetGEWYLEAGALVLADGGVCCIDEFDKMKELDRTALHEAMEQQTISIAKAGIVTTLNARCSILAAANPKGG 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  463 -YDPKESVSVNIALGSPLLSRFDLVLVLLDTRNEDWDRIISSFIL--------ENKGYPSKSENLWSMEKMKTYFCLIRN 533
Cdd:cd17706    161 rYNPKLSPIENINLPSPLLSRFDLIFVIRDDPDEERDEELAEHIIdlhrgsdpEEQVKPEEDGIPIDIELLRKYILYARQ 240

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1409931530  534 LHPTLSEVSNQVLLRYYQMQRQSDSRN-AARTTIRLLESLIRLAEAHARLMFRSAVTLEDAVTAVSVMESS 603
Cdd:cd17706    241 IHPKISEEAREKLVRWYVELRKESERRsTIPITARQLESVIRLAEAHAKMRLSEVVTEEDVEEAIRLVRHS 311
MCM smart00350
minichromosome maintenance proteins;
116-603 5.87e-137

minichromosome maintenance proteins;


Pssm-ID: 214631 [Multi-domain]  Cd Length: 509  Bit Score: 424.37  E-value: 5.87e-137
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530   116 KTKDVGHFLSVTGTVIRTSLVKVLEFERDYMCNKCKHVFmveADFEQYYTFSRPSSCPSLASCDSSKFSCLSDLSsspaR 195
Cdd:smart00350    9 RADHLGKLVRISGIVTRTSGVRPKLKRASFTCEKCGATL---GPEIQSGRETEPTVCPPRECQSPTPFSLNHERS----T 81

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530   196 CRDYQEIKIQEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYGVVmqRWKPFQRDV-----RCEVEIVLKANYVQV 270
Cdd:smart00350   82 FIDFQKIKLQESPEEVPVGQLPRSVDVILDGDLVDKAKPGDRVEVTGIY--RNVPYGFKLntvkgLPVFATYIEANHVRK 159

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530   271 NNEQSSGMVMDEDTRK----EFEDFWEHYKSDPFAgrNEILASLCPQVFGMYLVKLAVAMVLAGGIQRTDAAGTRVRGES 346
Cdd:smart00350  160 LDYKRSFEDSSFSVQSlsdeEEEEIRKLSKDPDIY--ERLARSLAPSIYGHEDIKKAILLLLFGGVHKNLPDGMKIRGDI 237

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530   347 HLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGLTVTAVKD--SGEWNLEAGALVLADAGLCCIDEFNSLKEHDR 424
Cdd:smart00350  238 NILLCGDPGTAKSQLLKYVEKTAPRAVYTTGKGSSAVGLTAAVTRDpeTREFTLEAGALVLADNGVCCIDEFDKMDDSDR 317

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530   425 TSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNP-KGQYDPKESVSVNIALGSPLLSRFDLVLVLLDTRNEDWDRIISS 503
Cdd:smart00350  318 TAIHEAMEQQTISIAKAGITTTLNARCSVLAAANPiGGRYDPKLTPEENIDLPAPILSRFDLLFVVLDEVDEERDRELAK 397

                           410       420       430       440       450       460       470       480
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530   504 FILENKGY-----PSKSENLWSMEKMKTYFCLIR-NLHPTLSEVSNQVLLRYY----QMQRQSDSRNAARTTIRLLESLI 573
Cdd:smart00350  398 HVVDLHRYshpeeDEAFEPPLSQEKLRKYIAYAReKIKPKLSEEAADKLVKAYvdlrKEDSQTESRSSIPITVRQLESII 477

                           490       500       510
                    ....*....|....*....|....*....|
gi 1409931530   574 RLAEAHARLMFRSAVTLEDAVTAVSVMESS 603
Cdd:smart00350  478 RLSEAHAKMRLSDVVEEADVEEAIRLLRES 507
MCM6 cd17757
DNA replication licensing factor Mcm6; Mcm6 is a helicase that play an important role in ...
 306-603 4.78e-100

DNA replication licensing factor Mcm6; Mcm6 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350663 [Multi-domain]  Cd Length: 307  Bit Score: 318.93  E-value: 4.78e-100
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  306 ILASLCPQVFGMYLVKLAVAMVLAGGIQRTDAAGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGL 385
Cdd:cd17757      2 LVRSIAPSIYGHEEVKKGILLMLLGGVHKITREGISLRGDINVCIVGDPSTAKSQFLKYVEEFSPRAVYTSGKASSAAGL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  386 TVTAVKD--SGEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNP-KGQ 462
Cdd:cd17757     82 TAAVVRDeeTGDFVIEAGALMLADNGICCIDEFDKMDIKDQVAIHEAMEQQTISITKAGIQATLNARTSILAAANPvGGR 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  463 YDPKESVSVNIALGSPLLSRFDLVLVLLDTRNEDWDRIISSFILENKGYPSKSENL-WSMEKMKTYFCLIRNLHPTLSEV 541
Cdd:cd17757    162 YDRSKSLKQNINISAPIMSRFDLFFVLLDECNEVTDYAIASHIVDLHSKREEAIEPpFTAEQLKRYIAYARTFKPKLTKE 241

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1409931530  542 SNQVLLRYYQMQRQSD----SRNAARTTIRLLESLIRLAEAHARLMFRSAVTLEDAVTAVSVMESS 603
Cdd:cd17757    242 AKDELVEQYKELRQDDasgsTRSSYRITVRQLESLIRLSEAIARLHCSDEVTPEHVEEAARLLKKS 307
MCM pfam00493
MCM P-loop domain;
305-508 3.62e-99

MCM P-loop domain;


Pssm-ID: 459830 [Multi-domain]  Cd Length: 224  Bit Score: 313.31  E-value: 3.62e-99
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  305 EILA-SLCPQVFGMYLVKLAVAMVLAGGIQRTDAAGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSA 383
Cdd:pfam00493   16 DKLAdSIAPSIYGHEDVKKAILLQLFGGVKKILPDGTRLRGDINVLLVGDPGTAKSQLLKYVEKIAPRAVYTSGKGSSAA 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  384 GLTVTAVKD--SGEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPK- 460
Cdd:pfam00493   96 GLTAAVVRDpvTGEFVLEAGALVLADGGVCCIDEFDKMNDEDRVALHEAMEQQTISIAKAGIVATLNARCSILAAANPIf 175

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 1409931530  461 GQYDPKESVSVNIALGSPLLSRFDLVLVLLDTRNEDWDRIISSFILEN 508
Cdd:pfam00493  176 GRYDPKKSIAENINLPPPLLSRFDLIFVLLDKPDEEKDERLAKHIVDL 223
MCM_arch cd17761
archaeal MCM protein; archaeal MCM proteins form a homohexameric ring homologous to the ...
 306-603 2.79e-97

archaeal MCM protein; archaeal MCM proteins form a homohexameric ring homologous to the eukaryotic Mcm2-7 helicase and also function as the replicative helicase at the replication fork


Pssm-ID: 350667 [Multi-domain]  Cd Length: 308  Bit Score: 311.69  E-value: 2.79e-97
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  306 ILASLCPQVFGMYLVKLAVAMVLAGGIQRTDAAGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGL 385
Cdd:cd17761      3 IISSIAPSIYGHEDVKEAIALQLFGGVPKVLPDGTRIRGDIHILLVGDPGTAKSQLLKYVSKVAPRAVYTTGKGSTAAGL 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  386 TVTAVKD--SGEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPK-GQ 462
Cdd:cd17761     83 TAAVVRDegTGEWYLEAGALVLADKGIAVVDEIDKMRKEDRSALHEAMEQQTISIAKAGIVATLNARAAVLAAANPKfGR 162

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  463 YDPKESVSVNIALGSPLLSRFDLVLVLLDTRNEDWDRIISSFILE--NKGYPSKSENLWSMEKMKTYFCLIR-NLHPTLS 539
Cdd:cd17761    163 FDSYRPVAEQIDLPPTLLSRFDLIFVLKDTPNEEKDRRLANHILDthSGGEMREIKPEIDPDLLRKYIAYARkNVRPVLT 242

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1409931530  540 EVSNQVLLRYYQMQRQS--DSRNAARTTIRLLESLIRLAEAHARLMFRSAVTLEDAVTAVSVMESS 603
Cdd:cd17761    243 EEAKQLIKDFYVEMRKSgqETPSPVPITARQLEALVRLSEASARMRLSQEVTLEDAERAIRIMLNC 308
MCM2 cd17753
DNA replication licensing factor Mcm2; Mcm2 is a helicase that play an important role in ...
 306-603 1.09e-92

DNA replication licensing factor Mcm2; Mcm2 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350659 [Multi-domain]  Cd Length: 325  Bit Score: 299.75  E-value: 1.09e-92
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  306 ILASLCPQVFGMYLVKLAVAMVLAGGIQRTDAAGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGL 385
Cdd:cd17753      2 IINSIAPSIYGHDDIKTAIALALFGGVAKNPGGKHRIRGDINVLLLGDPGTAKSQFLKYVEKTAHRAVFTTGQGASAVGL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  386 TVTAVKD--SGEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPK-GQ 462
Cdd:cd17753     82 TASVRKDpvTKEWTLEGGALVLADKGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCSVIAAANPIgGR 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  463 YDPKESVSVNIALGSPLLSRFDLVLVLLDTRNEDWDRIISSFILEN--KGYPSKSENLWSMEK----------------- 523
Cdd:cd17753    162 YNPTLTFAQNVNLTEPILSRFDILCVVRDTVDPEEDERLAKFVVGShvRSHPENDEDREGEEEknqrqrpketkvepipq 241

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  524 --MKTYFCLIR-NLHPTLSEVSNQVLLRYY-QMQRQSDSRNAARTTIRLLESLIRLAEAHARLMFRSAVTLEDAVTAVSV 599
Cdd:cd17753    242 elLRKYIHYAReKVRPKLNQMDMDKVSRVYaDLRKESMATGSLPITVRHLESIIRISEAHAKMHLREYVSEEDVDMAIRV 321


                   ....
gi 1409931530  600 MESS 603
Cdd:cd17753    322 MLDS 325
MCM7 cd17758
DNA replication licensing factor Mcm7; Mcm7 is a helicase that play an important role in ...
 308-603 1.68e-89

DNA replication licensing factor Mcm7; Mcm7 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350664 [Multi-domain]  Cd Length: 306  Bit Score: 290.47  E-value: 1.68e-89
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  308 ASLCPQVFGMYLVKLAVAMVLAGGIQRTdAAGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGLTV 387
Cdd:cd17758      4 ASIAPEIYGHEDVKKALLLLLVGGVDKR-GDGMKIRGDINICLMGDPGVAKSQLLKYICRIAPRSVYTTGRGSSGVGLTA 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  388 TAVKD--SGEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPK-GQYD 464
Cdd:cd17758     83 AVMKDpvTGEMTLEGGALVLADQGICCIDEFDKMDESDRTAIHEVMEQQTISIAKAGITTTLNARTSILAAANPAyGRYN 162

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  465 PKESVSVNIALGSPLLSRFDLVLVLLDTRNEDWDRIISSFIL----ENKGYPSKSENLwSMEKMKTYFCLIRNLHPTLS- 539
Cdd:cd17758    163 PRRSPEQNINLPAALLSRFDLLFLILDKPDRDNDLRLAEHVTyvhqHNKQPDSDFEPL-DPKLLRAYIALAKRKRPTVPp 241

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1409931530  540 EVSNQVLLRYYQMQRQS-DSRNAARTTIRLLESLIRLAEAHARLMFRSAVTLEDAVTAVSVMESS 603
Cdd:cd17758    242 ALADYIVQAYVEMRQEAkRSKDFTFTTPRTLLAILRLSQALARLRLSDSVEIDDVEEALRLMEMS 306
MCM4 cd17755
DNA replication licensing factor Mcm4; Mcm4 is a helicase that play an important role in ...
 306-603 2.44e-89

DNA replication licensing factor Mcm4; Mcm4 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350661 [Multi-domain]  Cd Length: 309  Bit Score: 290.11  E-value: 2.44e-89
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  306 ILA-SLCPQVFGMYLVKLAVAMVLAGGIQRTDA-AGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSA 383
Cdd:cd17755      1 RLArSIAPSIYELEDVKKGILLQLFGGTRKDFTkTGGKYRGDINILLCGDPGTSKSQLLQYVHKISPRGVYTSGKGSSAV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  384 GLTVTAVKD--SGEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPKG 461
Cdd:cd17755     81 GLTAYVTRDpdTKQLVLESGALVLSDGGICCIDEFDKMSDSTRSVLHEVMEQQTLSIAKAGIITTLNARTSILASANPIG 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  462 -QYDPKESVSVNIALGSPLLSRFDLVLVLLDTRNEDWDRIISSFI----LENKGyPSKSENLWSMEKMKTYFCLIR-NLH 535
Cdd:cd17755    161 sRYNPKLTVVENIDLPPTLLSRFDLIYLVLDKVDEKYDRRLAKHLvslyLEDTP-EHIQDEVLDVEVLTDYISYAReHIH 239

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  536 PTLSEVSNQVLLR-YYQMQRQSDSRNAART-TIRLLESLIRLAEAHARLMFRSAVTLEDAVTAVSVMESS 603
Cdd:cd17755    240 PKLSEEAAQELVQaYVDMRKMGSDARKRITaTPRQLESLIRLAEAHAKMRLSNVVEAEDVEEAVRLIREA 309
MCM5 cd17756
DNA replication licensing factor Mcm5; Mcm5 is a helicase that play an important role in ...
 306-603 8.77e-83

DNA replication licensing factor Mcm5; Mcm5 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350662 [Multi-domain]  Cd Length: 317  Bit Score: 272.33  E-value: 8.77e-83
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  306 ILASLCPQVFGMYLVKLAVAMVLAGGIQRTDAAGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGL 385
Cdd:cd17756      2 ISKSIAPSIYGNEDIKKAIACLLFGGSRKRLPDGMRLRGDINVLLLGDPGTAKSQLLKFVEKVAPIGVYTSGKGSSAAGL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  386 TVTAVKDS--GEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPK-GQ 462
Cdd:cd17756     82 TASVMRDPstREFYLEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRTSVLAAANPVfGR 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  463 YDPKESVSVNIALGSPLLSRFDLVLVLLDTRNEDWDRIISSFILE------NKGYPSKSENLWSMEKMKTYFCLIR-NLH 535
Cdd:cd17756    162 YDDLKTPGDNIDFQTTILSRFDMIFIVKDKHDEERDITIAKHVINihasarKASQSQENEGEIPISKLKRYIAYCRaKCA 241

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1409931530  536 PTLSEVSNQVLLRYY--------QMQRQSDSRNAARTTIRLLESLIRLAEAHARLMFRSAVTLEDAVTAVSVMESS 603
Cdd:cd17756    242 PRLSEEAAEKLSNHYvtirkdvrQNELESDNRSSIPITVRQLEAIIRISESLAKMELSPIATEKHVEEAIRLFQVS 317
MCM3 cd17754
DNA replication licensing factor Mcm3; Mcm3 is a helicase that play an important role in ...
 309-600 4.11e-81

DNA replication licensing factor Mcm3; Mcm3 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350660 [Multi-domain]  Cd Length: 299  Bit Score: 267.02  E-value: 4.11e-81
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  309 SLCPQVFGMYLVKLAVAMVLAGGIQRTDAAGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGLT-- 386
Cdd:cd17754      5 SLAPSIYGHEYIKKAILLMLLGGVEKNLENGSHLRGDINILLVGDPSVAKSQLLRYVLNTAPLAIATTGRGSSGVGLTaa 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  387 VTAVKDSGEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNP-KGQYDP 465
Cdd:cd17754     85 VTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDIDRVAIHEVMEQQTVTIAKAGIHASLNARCSVLAAANPvYGRYDV 164

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  466 KESVSVNIALGSPLLSRFDLVLVLLDTRNEDWDRIISSFILENKGYpsksenlwsMEKMKTYFCLIRNL-HPTLSEVSNQ 544
Cdd:cd17754    165 YKTPMENIGLPDSLLSRFDLLFIVLDDIDEERDRSISEHVLRMHRY---------IKFLRKYIHYAKERiKPKLTQEAAE 235

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1409931530  545 VLLRYYQMQRQSDS--RNAART---TIRLLESLIRLAEAHARLMFRSAVTLEDAVTAVSVM 600
Cdd:cd17754    236 YIAEEYADLRNDDNtkTDKARTspiTARTLETLIRLATAHAKARLSKTVDKVDAEVALNLL 296
MCM8 cd17759
DNA helicase Mcm8; Mcm8 plays an important role homologous recombination repair. It forms a ...
 306-603 1.13e-78

DNA helicase Mcm8; Mcm8 plays an important role homologous recombination repair. It forms a complex with Mcm9 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350665 [Multi-domain]  Cd Length: 289  Bit Score: 260.16  E-value: 1.13e-78
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  306 ILASLCPQVFGMYLVKLAVAMVLAGGIQRTDAAGTR--VRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSA 383
Cdd:cd17759      2 IVNSLCPAIYGHELVKAGLLLSLFGGKQKYADDKNRipIRGDPHVLIVGDPGLGKSQMLQAACNIAPRGVYVCGNTTTTS 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  384 GLTVTAVKD--SGEWNLEAGALVLADAGLCCIDEFNSL-KEHdrTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPK 460
Cdd:cd17759     82 GLTVTLTKDgrSGDFALEAGALVLGDQGICGIDEFDKMgSQH--QALLEAMEQQSVSLAKAGVVCSLPARTSVIAAANPV 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  461 -GQYDPKESVSVNIALGSPLLSRFDLVLVLLDTRNEDWDRIISSfilenkgypsksenlwSMEKMKTYFCLIR-NLHPTL 538
Cdd:cd17759    160 gGHYNKGKTVSENLKMGPALLSRFDLVFILLDTPSEEHDHLLSE----------------HHQLLRKYISYARqYVNPVL 223

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1409931530  539 SEVSNQVLLRYY-QMQRQSDSRNAARTTIRLLESLIRLAEAHARLMFRSAVTLEDAVTAVSVMESS 603
Cdd:cd17759    224 SKDASEALQEFYlELRKQNQLADSSPITTRQLESLIRLTEARARLELREEATKEDAEDVIEIMKES 289
PTZ00111 PTZ00111
DNA replication licensing factor MCM4; Provisional
 218-603 4.22e-57

DNA replication licensing factor MCM4; Provisional


Pssm-ID: 173403 [Multi-domain]  Cd Length: 915  Bit Score: 214.09  E-value: 4.22e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  218 RSMKVILEDDLVDSCKSGDDLTIYGVVMQ---RWKPFQRDVRCEVEIVLKANYVQVNNEQSSGMVMDE----DTRKEFED 290
Cdd:PTZ00111   346 EVINLNLYDDLIDSVKTGDRVTVVGILKVtpiRTSTTRRTLKSLYTYFVNVIHVKVINSTNANQPEKGlkylGNENDFSD 425

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  291 FwEHYK-----SDPFAGRnEILASLCPQVFGMYLVKLAVAMVLAGGIQRTDAAGTRV---------RGESHLLLVGDPGT 356
Cdd:PTZ00111   426 L-QVYKilelsRNPMIYR-ILLDSFAPSIKARNNVKIGLLCQLFSGNKNSSDFNKSPdacykvdnfRGIINVLLCGDPGT 503

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  357 GKSQFLKYAAKITPRSVLTTGIGSTSAGLTVT-AVKDS--GEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQ 433
Cdd:PTZ00111   504 AKSQLLHYTHLLSPRSIYTSGKSSSSVGLTASiKFNESdnGRAMIQPGAVVLANGGVCCIDELDKCHNESRLSLYEVMEQ 583

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  434 QTISVAKAGLVCKLNTRTTILAATNP-KGQYDPKESVSVNIALGSPLLSRFDLVLVLLDTRNEDWDRIISSFILENKGYP 512
Cdd:PTZ00111   584 QTVTIAKAGIVATLKAETAILASCNPiNSRYNKNKAVIENINISPSLFTRFDLIYLVLDHIDQDTDQLISLSIAKDFLLP 663

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  513 S---------------------------KSENLWSMEKMKTY--FCLIrNLHPTLSEVSNQVLLRYYQMQRQSDSRNAAR 563
Cdd:PTZ00111   664 HmtgsgndedtydrsntmhvedeslrseKDYNKNDLDMLRMYikFSKL-HCFPKLSDEAKKVITREYVKMRQGNFQTSNL 742

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1409931530  564 TTI-------------------------RLLESLIRLAEAHARLMFRSAVTLEDAVTAVSVMESS 603
Cdd:PTZ00111   743 DELehaqedddddlyyqssgtrmiyvssRMISSIIRISVSLARMRLSTVVTPADALQAVQIVKSS 807
MCM_OB pfam17207
MCM OB domain; This family contains an OB-fold found within MCM proteins. This domain contains ...
 116-243 2.41e-24

MCM OB domain; This family contains an OB-fold found within MCM proteins. This domain contains an insertion at the zinc binding motif.


Pssm-ID: 465381 [Multi-domain]  Cd Length: 126  Bit Score: 99.09  E-value: 2.41e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  116 KTKDVGHFLSVTGTVIRTSLVK---VLEFerdYMCNKCKHVFMVEadfeqyytFSRPSSCPSlASCDS-SKFSCLSDLSs 191
Cdd:pfam17207    6 RSEHIGKLVSVSGIVTRTSEVRpklKKAT---FTCRKCGHTVGVK--------ITEPTKCPN-PECGNkDPFKLVHEKS- 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1409931530  192 spaRCRDYQEIKIQEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYGV 243
Cdd:pfam17207   73 ---KFVDFQKIKIQESPEEVPAGELPRSLDVILDDDLVDRVKPGDRVTVTGI 121
MCM_lid pfam17855
MCM AAA-lid domain; This entry represents the AAA-lid domain found in MCM proteins.
 532-604 3.27e-17

MCM AAA-lid domain; This entry represents the AAA-lid domain found in MCM proteins.


Pssm-ID: 465534 [Multi-domain]  Cd Length: 86  Bit Score: 77.58  E-value: 3.27e-17
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1409931530  532 RNLHPTLSEVSNQVLLRYY-QM-QRQSDSRNAARTTIRLLESLIRLAEAHARLMFRSAVTLEDAVTAVSVMESSM 604
Cdd:pfam17855   12 EKIKPKLSEEAREKLVDAYvELrKESTGSGSSIPITVRQLESLIRLSEAHAKMRLSEIVTEEDVEEAIRLLKESL 86
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 347-483 1.44e-08

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 54.61  E-value: 1.44e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  347 HLLLVGDPGTGKSQFLK-YAAKITPRSVLTTGIgstSAGLTVTAVKdsGEWNLEAGALVLADAGL---------CCIDEF 416
Cdd:pfam07728    1 GVLLVGPPGTGKTELAErLAAALSNRPVFYVQL---TRDTTEEDLF--GRRNIDPGGASWVDGPLvraaregeiAVLDEI 75

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1409931530  417 NSLKEHDRTSIHEAMEQQTISVAKAG-LVCKLNTRTTILAATNPkGQYDPKEsvsvniaLGSPLLSRF 483
Cdd:pfam07728   76 NRANPDVLNSLLSLLDERRLLLPDGGeLVKAAPDGFRLIATMNP-LDRGLNE-------LSPALRSRF 135
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 739-1004 3.70e-05

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 48.15  E-value: 3.70e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  739 DPTSSPEIAPESTIVSPnvktteknvnlKISNNKSQGKEKHGPQQRSKLLEAGHLPSSGAMNAPLRSHG-VKRTKASQAV 817
Cdd:PTZ00449   505 DKHDEPPEGPEASGLPP-----------KAPGDKEGEEGEHEDSKESDEPKEGGKPGETKEGEVGKKPGpAKEHKPSKIP 573

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  818 VVSEAGRGDEEDSVPRRlPKLLKEGSQNVCRSTTrVRPLPPTVPLSLSIPSpgSGKRSGTPKRKRRKSAQVEEPEPEGME 897
Cdd:PTZ00449   574 TLSKKPEFPKDPKHPKD-PEEPKKPKRPRSAQRP-TRPKSPKLPELLDIPK--SPKRPESPKSPKRPPPPQRPSSPERPE 649

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  898 TPtvKLAKftfkqKTKLTHSPegQGPIPPSASEIAVDSSKIPQQRTRReaAVPVVAPGKSTSTSGDRCSDQLHGKTKELS 977
Cdd:PTZ00449   650 GP--KIIK-----SPKPPKSP--KPPFDPKFKEKFYDDYLDAAAKSKE--TKTTVVLDESFESILKETLPETPGTPFTTP 718

                          250       260
                   ....*....|....*....|....*..
gi 1409931530  978 RQPPDSNPPREEREQGPKRRVIQPKPE 1004
Cdd:PTZ00449   719 RPLPPKLPRDEEFPFEPIGDPDAEQPD 745
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 346-489 3.72e-05

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 45.21  E-value: 3.72e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  346 SHLLLVGDPGTGKSQFLKYAAKITPRSVLTTgIGSTSAGLTVTAVKDS--GEWNLEAGALVLADAGLCC--IDEFNSLKE 421
Cdd:cd00009     20 KNLLLYGPPGTGKTTLARAIANELFRPGAPF-LYLNASDLLEGLVVAElfGHFLVRLLFELAEKAKPGVlfIDEIDSLSR 98

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1409931530  422 HDRTSIHEAMEQQTISVakaglvcKLNTRTTILAATNPKGQYDPKEsvsvnialgsPLLSRFDLVLVL 489
Cdd:cd00009     99 GAQNALLRVLETLNDLR-------IDRENVRVIGATNRPLLGDLDR----------ALYDRLDIRIVI 149
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 700-1004 1.83e-04

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 45.53  E-value: 1.83e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  700 SSTERSGADSPP-GPGLNRPTSCNNSAENRDGRGDGLDWLDPTSSPEIAPESTIVSPNVKTTEKNVNLKISNNKSQgKEK 778
Cdd:NF033839   148 SSSSSSGSSTKPeTPQPENPEHQKPTTPAPDTKPSPQPEGKKPSVPDINQEKEKAKLAVATYMSKILDDIQKHHLQ-KEK 226

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  779 H----GPQQRSKLLEAGHLPSSGAMNAPLR-SHGVKRTKASQAVVVSEAGRGDEEDSvprrlPKLLKEGSQNVCRSTTRV 853
Cdd:NF033839   227 HrqivALIKELDELKKQALSEIDNVNTKVEiENTVHKIFADMDAVVTKFKKGLTQDT-----PKEPGNKKPSAPKPGMQP 301

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530  854 RPLPPTVPLSLSIPSPGSGKRSGTPKRKRRKSAQVEEPEPE---GMETPTVKLAKFTFKQKTKLTHSPEGQGPIPPSASE 930
Cdd:NF033839   302 SPQPEKKEVKPEPETPKPEVKPQLEKPKPEVKPQPEKPKPEvkpQLETPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPE 381

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1409931530  931 iavdsSKIPQQRTRREAAVPVVAPgkSTSTSGDRCSDQLHGKTKELSRQPpdsNPPREEREQGPKRRVIQPKPE 1004
Cdd:NF033839   382 -----TPKPEVKPQPEKPKPEVKP--QPEKPKPEVKPQPEKPKPEVKPQP---EKPKPEVKPQPEKPKPEVKPQ 445
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 347-491 4.82e-04

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 41.59  E-value: 4.82e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931530   347 HLLLVGDPGTGKSQFLKYAAKITPR---SVLTTGIGSTSAGLTVTAVKDSGEWNLEAG------ALVLADA-----GLCC 412
Cdd:smart00382    4 VILIVGPPGSGKTTLARALARELGPpggGVIYIDGEDILEEVLDQLLLIIVGGKKASGsgelrlRLALALArklkpDVLI 83

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1409931530   413 IDEFNSLKEHDRtsiheAMEQQTISVAKAGLVCKLNTRTTILAATNPKGQYDPKEsvsvnialgspLLSRFDLVLVLLD 491
Cdd:smart00382   84 LDEITSLLDAEQ-----EALLLLLEELRLLLLLKSEKNLTVILTTNDEKDLGPAL-----------LRRRFDRRIVLLL 146
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH