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Conserved domains on  [gi|58037305|ref|NP_082704|]
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alpha-(1,3)-fucosyltransferase 11 precursor [Mus musculus]

Protein Classification

glycosyltransferase family 10 fucosyltransferase( domain architecture ID 581089)

glycosyltransferase family 10 fucosyltransferase transfers fucose from GDP-Fucose to GlcNAc in an alpha1,3 linkage

CAZY:  GT10
EC:  2.4.1.-
Gene Ontology:  GO:0006486|GO:0008417
PubMed:  9451017|9334165

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glyco_transf_10 super family cl02988
Glycosyltransferase family 10 (fucosyltransferase) C-term; This is the C-terminal domain of a ...
 212-351 5.40e-40

Glycosyltransferase family 10 (fucosyltransferase) C-term; This is the C-terminal domain of a family of fucosyltransferases. This enzyme transfers fucose from GDP-Fucose to GlcNAc in an alpha1,3 linkage. This family is known as glycosyltransferase family 10. The C-terminal domain is the likely binding-region for ADP (manuscript in publication).


The actual alignment was detected with superfamily member pfam00852:

Pssm-ID: 459962  Cd Length: 176  Bit Score: 142.31  E-value: 5.40e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037305   212 SHCDVPSDRDRYVRELMRYIPVDSYGKCLQNREPPtvrlqdtatatteDPELMAFLSRYKFHLALENAICNDYMTEKLWR 291
Cdd:pfam00852  13 SNCNTSSARVKYYNELQKHIEVDVYGRCGNLKPLS-------------PGCYLMLISSYKFYLAFENSICKDYITEKLWN 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 58037305   292 PMHLGAVPVYRGSP--SVRDWMPnNHSVILIDDFESPQKLAEFIDFLDKNDDEYMKYLAYKQ 351
Cdd:pfam00852  80 ALLRGAVPVVLGPPraNYERFAP-PDSFIHVDDFPSPKELAEYLLYLDKNDTLYLRYFWWRK 140
Glyco_tran_10_N super family cl25278
Fucosyltransferase, N-terminal; This is the N-terminal domain of a family of ...
 115-176 1.42e-04

Fucosyltransferase, N-terminal; This is the N-terminal domain of a family of fucosyltransferases. This enzyme transfers fucose from GDP-Fucose to GlcNAc in an alpha1,3 linkage. This family is known as glycosyltransferase family 10. The N-terminal domain is the likely binding-region for the fucose-like substrate (manuscript in publication).


The actual alignment was detected with superfamily member pfam17039:

Pssm-ID: 465336  Cd Length: 109  Bit Score: 41.14  E-value: 1.42e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 58037305   115 ALLFYGTDFRAADAPLP---RLAHQSWALLHEESPLNNFLLSHGPGirLFNLTATFSRHSDYPLP 176
Cdd:pfam17039  45 AVVFHHRDISLDLKDLPyspRPPGQRWVWFNLESPTNTPRLPGLDN--FFNWTMTYRRDSDIFTP 107
 
Name Accession Description Interval E-value
Glyco_transf_10 pfam00852
Glycosyltransferase family 10 (fucosyltransferase) C-term; This is the C-terminal domain of a ...
 212-351 5.40e-40

Glycosyltransferase family 10 (fucosyltransferase) C-term; This is the C-terminal domain of a family of fucosyltransferases. This enzyme transfers fucose from GDP-Fucose to GlcNAc in an alpha1,3 linkage. This family is known as glycosyltransferase family 10. The C-terminal domain is the likely binding-region for ADP (manuscript in publication).


Pssm-ID: 459962  Cd Length: 176  Bit Score: 142.31  E-value: 5.40e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037305   212 SHCDVPSDRDRYVRELMRYIPVDSYGKCLQNREPPtvrlqdtatatteDPELMAFLSRYKFHLALENAICNDYMTEKLWR 291
Cdd:pfam00852  13 SNCNTSSARVKYYNELQKHIEVDVYGRCGNLKPLS-------------PGCYLMLISSYKFYLAFENSICKDYITEKLWN 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 58037305   292 PMHLGAVPVYRGSP--SVRDWMPnNHSVILIDDFESPQKLAEFIDFLDKNDDEYMKYLAYKQ 351
Cdd:pfam00852  80 ALLRGAVPVVLGPPraNYERFAP-PDSFIHVDDFPSPKELAEYLLYLDKNDTLYLRYFWWRK 140
Glyco_tran_10_N pfam17039
Fucosyltransferase, N-terminal; This is the N-terminal domain of a family of ...
 115-176 1.42e-04

Fucosyltransferase, N-terminal; This is the N-terminal domain of a family of fucosyltransferases. This enzyme transfers fucose from GDP-Fucose to GlcNAc in an alpha1,3 linkage. This family is known as glycosyltransferase family 10. The N-terminal domain is the likely binding-region for the fucose-like substrate (manuscript in publication).


Pssm-ID: 465336  Cd Length: 109  Bit Score: 41.14  E-value: 1.42e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 58037305   115 ALLFYGTDFRAADAPLP---RLAHQSWALLHEESPLNNFLLSHGPGirLFNLTATFSRHSDYPLP 176
Cdd:pfam17039  45 AVVFHHRDISLDLKDLPyspRPPGQRWVWFNLESPTNTPRLPGLDN--FFNWTMTYRRDSDIFTP 107
 
Name Accession Description Interval E-value
Glyco_transf_10 pfam00852
Glycosyltransferase family 10 (fucosyltransferase) C-term; This is the C-terminal domain of a ...
 212-351 5.40e-40

Glycosyltransferase family 10 (fucosyltransferase) C-term; This is the C-terminal domain of a family of fucosyltransferases. This enzyme transfers fucose from GDP-Fucose to GlcNAc in an alpha1,3 linkage. This family is known as glycosyltransferase family 10. The C-terminal domain is the likely binding-region for ADP (manuscript in publication).


Pssm-ID: 459962  Cd Length: 176  Bit Score: 142.31  E-value: 5.40e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037305   212 SHCDVPSDRDRYVRELMRYIPVDSYGKCLQNREPPtvrlqdtatatteDPELMAFLSRYKFHLALENAICNDYMTEKLWR 291
Cdd:pfam00852  13 SNCNTSSARVKYYNELQKHIEVDVYGRCGNLKPLS-------------PGCYLMLISSYKFYLAFENSICKDYITEKLWN 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 58037305   292 PMHLGAVPVYRGSP--SVRDWMPnNHSVILIDDFESPQKLAEFIDFLDKNDDEYMKYLAYKQ 351
Cdd:pfam00852  80 ALLRGAVPVVLGPPraNYERFAP-PDSFIHVDDFPSPKELAEYLLYLDKNDTLYLRYFWWRK 140
Glyco_tran_10_N pfam17039
Fucosyltransferase, N-terminal; This is the N-terminal domain of a family of ...
 115-176 1.42e-04

Fucosyltransferase, N-terminal; This is the N-terminal domain of a family of fucosyltransferases. This enzyme transfers fucose from GDP-Fucose to GlcNAc in an alpha1,3 linkage. This family is known as glycosyltransferase family 10. The N-terminal domain is the likely binding-region for the fucose-like substrate (manuscript in publication).


Pssm-ID: 465336  Cd Length: 109  Bit Score: 41.14  E-value: 1.42e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 58037305   115 ALLFYGTDFRAADAPLP---RLAHQSWALLHEESPLNNFLLSHGPGirLFNLTATFSRHSDYPLP 176
Cdd:pfam17039  45 AVVFHHRDISLDLKDLPyspRPPGQRWVWFNLESPTNTPRLPGLDN--FFNWTMTYRRDSDIFTP 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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