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Conserved domains on  [gi|30842800|ref|NP_082915|]
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tetratricopeptide repeat protein 7A isoform 2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TTC7_N super family cl44857
Tetratricopeptide repeat protein 7 N-terminal; This is the N-terminal domain of TTC7, a ...
 11-404 3.88e-140

Tetratricopeptide repeat protein 7 N-terminal; This is the N-terminal domain of TTC7, a protein that forms the regulatory subunit of the PI4KIIIalpha complex (also known as PI4KA). This complex is composed of PI4KIIIalpha, TTC7 and FAM126A and catalyzes the first step in plasma membrane phosphoinositide synthesis. This TTC7 N-terminal domain contains basic residues suitable for interaction with the acidic inner leaflet of the plasma membrane and is required for localising the active site near its substrate. TTC7 acts as a bridge between PI4KA and EFR3B-FAM126A, via direct interactions. ERF3B is not part of the complex but contributes to its recruitment to the membrane.


The actual alignment was detected with superfamily member pfam19440:

Pssm-ID: 466084  Cd Length: 386  Bit Score: 420.72  E-value: 3.88e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800    11 LKVESEVERCRAEGQWDRMFELARHLqmlgisgggssnrrnsPSGRfttLDTDDFVKLLLAEALLEQCLKDNHDKIKNSI 90
Cdd:pfam19440  10 YRLETEIERCRSECQWDKVPELVEQL----------------KAKR---IANDDMANLLLGEGKLEQYLKENPPILENST 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800    91 pllEKTDHRLNEAKDHLSSLLNNGKLPPQYMCEAMLILGKLHYVEGSYRDAVSMYARAGIDDISVENKPLYQMRLLSEAF 170
Cdd:pfam19440  71 ---EKNQPKLSEAKKHLTSALDRGNLKPEFLQEAHLLLAKLNYVEGDYREALNMYARAGLDDLTLKELPVYRLRLLAEAY 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800   171 VIKGLSLERLPNSVASHIRLTEREEEVVACFERASWVAQVFLQELEKTSNNSTSRHLKGSLSP-DYELSYFLEAALQSAY 249
Cdd:pfam19440 148 AIKGLCLEKQAVSSSSRVRLAEREEEMITCYEKAGDIALLYLQELERINSNTQNRSPKPGPPSqEQELGFFLETALQRAY 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800   250 VKNLKKGNIVKGMRELREILRTVETKATQNFKVVAAKHLAGVLLHSLSEDCYWSPLSHPLPEFMnKEENSFVTQT----- 324
Cdd:pfam19440 228 VLYFKKGNLARGVGRYREILRAVETRTTQNLRMTIARQLAEVLLRGVCEQSYWNPLEDPPPQSL-LDEPLKGTNTknytp 306

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800   325 LRKPHLYEGDNLYCPKDNIEEALLLLLISESMATRDVVLSRAPEQAEDRKVSLQNASAIYDLLSITLGRRGQYVMLSECL 404
Cdd:pfam19440 307 SRKPRVYSGENIFCPQDNVEEALLLLLISESMANRDAVLSRSPEHREARIISLQNATAVYDLLTIAMGRRGQYEMLSECL 386
Spy super family cl27809
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 710-849 1.07e-20

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG3914:

Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 97.37  E-value: 1.07e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800 710 LEQIWLQAAELFMEQRQLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGSFEEAKQLYKEALTVNPDGVRIMHSLGLML 789
Cdd:COG3914  77 LAALLELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEAL 156

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800 790 SQLGHKSLAQKVLRDAVERQSTFHEAWQGLGEVLQDQGQNEAAVDCFLTALELEASSPVL 849
Cdd:COG3914 157 RRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADA 216
PEP_TPR_lipo super family cl37187
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 378-848 9.67e-07

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


The actual alignment was detected with superfamily member TIGR02917:

Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 52.78  E-value: 9.67e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800   378 QNASAIYDLLSITLGRRGQYVMLSECLERAMKCAFGEFHLWYQVALSMVACGKSAYAVSLLRECMKLQPSDPTVPLMAAk 457
Cdd:TIGR02917 360 PDDPAALSLLGEAYLALGDFEKAAEYLAKATELDPENAAARTQLGISKLSQGDPSEAIADLETAAQLDPELGRADLLLI- 438

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800   458 vcigsLHWLEEAEhfatvvIGLGEEAGESLPKGYLALGLTYSLQAtdATLKSKQDElhRKALQTLERARELAPDDPQIIF 537
Cdd:TIGR02917 439 -----LSYLRSGQ------FDKALAAAKKLEKKQPDNASLHNLLG--AIYLGKGDL--AKAREAFEKALSIEPDFFPAAA 503

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800   538 YVALQLALVRQISSAMERLQEALTMCRDDANALHLLALLFSAQKYYQHALDVINMAITEHPENFNL-------MFTKVKL 610
Cdd:TIGR02917 504 NLARIDIQEGNPDDAIQRFEKVLTIDPKNLRAILALAGLYLRTGNEEEAVAWLEKAAELNPQEIEPalalaqyYLGKGQL 583

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800   611 EQVLKGPEEALVTCRQMLRLWQTLYNFSQLGGLEKDG--SFEGLTvkKQNG----IHLTLPDAHDADSGSRRAssiaasr 684
Cdd:TIGR02917 584 KKALAILNEAADAAPDSPEAWLMLGRAQLAAGDLNKAvsSFKKLL--ALQPdsalALLLLADAYAVMKNYAKA------- 654

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800   685 LEEAMSELTLTTSVLKQGPMQlwttleqiwlqaAELFMEQRQLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGSFEEA 764
Cdd:TIGR02917 655 ITSLKRALELKPDNTEAQIGL------------AQLLLAAKRTESAKKIAKSLQKQHPKAALGFELEGDLYLRQKDYPAA 722

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800   765 KQLYKEALTVNPDGVRIMHsLGLMLSQLGHKSLAQKVLRDAVERQSTFHEAWQGLGEVLQDQGQNEAAVDCFLTALELEA 844
Cdd:TIGR02917 723 IQAYRKALKRAPSSQNAIK-LHRALLASGNTAEAVKTLEAWLKTHPNDAVLRTALAELYLAQKDYDKAIKHYQTVVKKAP 801


                  ....
gi 30842800   845 SSPV 848
Cdd:TIGR02917 802 DNAV 805
 
Name Accession Description Interval E-value
TTC7_N pfam19440
Tetratricopeptide repeat protein 7 N-terminal; This is the N-terminal domain of TTC7, a ...
 11-404 3.88e-140

Tetratricopeptide repeat protein 7 N-terminal; This is the N-terminal domain of TTC7, a protein that forms the regulatory subunit of the PI4KIIIalpha complex (also known as PI4KA). This complex is composed of PI4KIIIalpha, TTC7 and FAM126A and catalyzes the first step in plasma membrane phosphoinositide synthesis. This TTC7 N-terminal domain contains basic residues suitable for interaction with the acidic inner leaflet of the plasma membrane and is required for localising the active site near its substrate. TTC7 acts as a bridge between PI4KA and EFR3B-FAM126A, via direct interactions. ERF3B is not part of the complex but contributes to its recruitment to the membrane.


Pssm-ID: 466084  Cd Length: 386  Bit Score: 420.72  E-value: 3.88e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800    11 LKVESEVERCRAEGQWDRMFELARHLqmlgisgggssnrrnsPSGRfttLDTDDFVKLLLAEALLEQCLKDNHDKIKNSI 90
Cdd:pfam19440  10 YRLETEIERCRSECQWDKVPELVEQL----------------KAKR---IANDDMANLLLGEGKLEQYLKENPPILENST 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800    91 pllEKTDHRLNEAKDHLSSLLNNGKLPPQYMCEAMLILGKLHYVEGSYRDAVSMYARAGIDDISVENKPLYQMRLLSEAF 170
Cdd:pfam19440  71 ---EKNQPKLSEAKKHLTSALDRGNLKPEFLQEAHLLLAKLNYVEGDYREALNMYARAGLDDLTLKELPVYRLRLLAEAY 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800   171 VIKGLSLERLPNSVASHIRLTEREEEVVACFERASWVAQVFLQELEKTSNNSTSRHLKGSLSP-DYELSYFLEAALQSAY 249
Cdd:pfam19440 148 AIKGLCLEKQAVSSSSRVRLAEREEEMITCYEKAGDIALLYLQELERINSNTQNRSPKPGPPSqEQELGFFLETALQRAY 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800   250 VKNLKKGNIVKGMRELREILRTVETKATQNFKVVAAKHLAGVLLHSLSEDCYWSPLSHPLPEFMnKEENSFVTQT----- 324
Cdd:pfam19440 228 VLYFKKGNLARGVGRYREILRAVETRTTQNLRMTIARQLAEVLLRGVCEQSYWNPLEDPPPQSL-LDEPLKGTNTknytp 306

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800   325 LRKPHLYEGDNLYCPKDNIEEALLLLLISESMATRDVVLSRAPEQAEDRKVSLQNASAIYDLLSITLGRRGQYVMLSECL 404
Cdd:pfam19440 307 SRKPRVYSGENIFCPQDNVEEALLLLLISESMANRDAVLSRSPEHREARIISLQNATAVYDLLTIAMGRRGQYEMLSECL 386
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 710-849 1.07e-20

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 97.37  E-value: 1.07e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800 710 LEQIWLQAAELFMEQRQLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGSFEEAKQLYKEALTVNPDGVRIMHSLGLML 789
Cdd:COG3914  77 LAALLELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEAL 156

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800 790 SQLGHKSLAQKVLRDAVERQSTFHEAWQGLGEVLQDQGQNEAAVDCFLTALELEASSPVL 849
Cdd:COG3914 157 RRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADA 216
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 605-843 2.02e-07

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 54.60  E-value: 2.02e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800   605 FTKVKLEQVLKGPEEALVTCRQMLRLWQTLYNFSQLGGLEKDGSFEGLTVKKQNGIHLTLPDAhDADSGSRRASSIAASR 684
Cdd:TIGR00990 242 FAESKAKEILETKPENLPSVTFVGNYLQSFRPKPRPAGLEDSNELDEETGNGQLQLGLKSPES-KADESYEEAARAFEKA 320

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800   685 LE-------EAMS-ELTLTTSVLKQGP----------MQLWTTLEQIWLQAAELFMEQRQLKEAGFCIQEAAGLFPTSHS 746
Cdd:TIGR00990 321 LDlgklgekEAIAlNLRGTFKCLKGKHlealadlsksIELDPRVTQSYIKRASMNLELGDPDKAEEDFDKALKLNSEDPD 400

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800   747 VLYMRGRLAEVKGSFEEAKQLYKEALTVNPDGVRIMHSLGLMLSQLGHKSLAQKVLRDAVERQSTFHEAWQGLGEVLQDQ 826
Cdd:TIGR00990 401 IYYHRAQLHFIKGEFAQAGKDYQKSIDLDPDFIFSHIQLGVTQYKEGSIASSMATFRRCKKNFPEAPDVYNYYGELLLDQ 480

                         250
                  ....*....|....*..
gi 30842800   827 GQNEAAVDCFLTALELE 843
Cdd:TIGR00990 481 NKFDEAIEKFDTAIELE 497
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 378-848 9.67e-07

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 52.78  E-value: 9.67e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800   378 QNASAIYDLLSITLGRRGQYVMLSECLERAMKCAFGEFHLWYQVALSMVACGKSAYAVSLLRECMKLQPSDPTVPLMAAk 457
Cdd:TIGR02917 360 PDDPAALSLLGEAYLALGDFEKAAEYLAKATELDPENAAARTQLGISKLSQGDPSEAIADLETAAQLDPELGRADLLLI- 438

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800   458 vcigsLHWLEEAEhfatvvIGLGEEAGESLPKGYLALGLTYSLQAtdATLKSKQDElhRKALQTLERARELAPDDPQIIF 537
Cdd:TIGR02917 439 -----LSYLRSGQ------FDKALAAAKKLEKKQPDNASLHNLLG--AIYLGKGDL--AKAREAFEKALSIEPDFFPAAA 503

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800   538 YVALQLALVRQISSAMERLQEALTMCRDDANALHLLALLFSAQKYYQHALDVINMAITEHPENFNL-------MFTKVKL 610
Cdd:TIGR02917 504 NLARIDIQEGNPDDAIQRFEKVLTIDPKNLRAILALAGLYLRTGNEEEAVAWLEKAAELNPQEIEPalalaqyYLGKGQL 583

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800   611 EQVLKGPEEALVTCRQMLRLWQTLYNFSQLGGLEKDG--SFEGLTvkKQNG----IHLTLPDAHDADSGSRRAssiaasr 684
Cdd:TIGR02917 584 KKALAILNEAADAAPDSPEAWLMLGRAQLAAGDLNKAvsSFKKLL--ALQPdsalALLLLADAYAVMKNYAKA------- 654

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800   685 LEEAMSELTLTTSVLKQGPMQlwttleqiwlqaAELFMEQRQLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGSFEEA 764
Cdd:TIGR02917 655 ITSLKRALELKPDNTEAQIGL------------AQLLLAAKRTESAKKIAKSLQKQHPKAALGFELEGDLYLRQKDYPAA 722

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800   765 KQLYKEALTVNPDGVRIMHsLGLMLSQLGHKSLAQKVLRDAVERQSTFHEAWQGLGEVLQDQGQNEAAVDCFLTALELEA 844
Cdd:TIGR02917 723 IQAYRKALKRAPSSQNAIK-LHRALLASGNTAEAVKTLEAWLKTHPNDAVLRTALAELYLAQKDYDKAIKHYQTVVKKAP 801


                  ....
gi 30842800   845 SSPV 848
Cdd:TIGR02917 802 DNAV 805
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 492-809 1.88e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 47.42  E-value: 1.88e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800 492 LALGLTYSLQATDATLKSKQDelhrKALQTLERARELAPDDPQIIFYVAlQLALVR-QISSAMERLQEALTMCRDDANAL 570
Cdd:COG2956   5 VAAALGWYFKGLNYLLNGQPD----KAIDLLEEALELDPETVEAHLALG-NLYRRRgEYDRAIRIHQKLLERDPDRAEAL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800 571 HLLALLFSAQKYYQHALDVINMAITEHPENFNLMFTKVKLEQVLKGPEEALVTCRQMLRLWQTLYNFS-QLGGLEkdgsf 649
Cdd:COG2956  80 LELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYcELAELY----- 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800 650 egltvkkqngihltlpdahdadsgsrrassIAASRLEEAMSELTlttSVLKQGPmqlwtTLEQIWLQAAELFMEQRQLKE 729
Cdd:COG2956 155 ------------------------------LEQGDYDEAIEALE---KALKLDP-----DCARALLLLAELYLEQGDYEE 196

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800 730 AGFCIQEAAGLFPTSHSVLYMRGRLAEVKGSFEEAKQLYKEALTVNPDgVRIMHSLGLMLSQLGHKSLAQKVLRDAVERQ 809
Cdd:COG2956 197 AIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPS-DDLLLALADLLERKEGLEAALALLERQLRRH 275
TPR_11 pfam13414
TPR repeat;
758-793 3.71e-03

TPR repeat;


Pssm-ID: 315977 [Multi-domain]  Cd Length: 42  Bit Score: 35.91  E-value: 3.71e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 30842800   758 KGSFEEAKQLYKEALTVNPDGVRIMHSLGLMLSQLG 793
Cdd:pfam13414   7 QGKYEEAIEAYKKALKLDPDNPEAYYNLGLAYYKLG 42
 
Name Accession Description Interval E-value
TTC7_N pfam19440
Tetratricopeptide repeat protein 7 N-terminal; This is the N-terminal domain of TTC7, a ...
 11-404 3.88e-140

Tetratricopeptide repeat protein 7 N-terminal; This is the N-terminal domain of TTC7, a protein that forms the regulatory subunit of the PI4KIIIalpha complex (also known as PI4KA). This complex is composed of PI4KIIIalpha, TTC7 and FAM126A and catalyzes the first step in plasma membrane phosphoinositide synthesis. This TTC7 N-terminal domain contains basic residues suitable for interaction with the acidic inner leaflet of the plasma membrane and is required for localising the active site near its substrate. TTC7 acts as a bridge between PI4KA and EFR3B-FAM126A, via direct interactions. ERF3B is not part of the complex but contributes to its recruitment to the membrane.


Pssm-ID: 466084  Cd Length: 386  Bit Score: 420.72  E-value: 3.88e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800    11 LKVESEVERCRAEGQWDRMFELARHLqmlgisgggssnrrnsPSGRfttLDTDDFVKLLLAEALLEQCLKDNHDKIKNSI 90
Cdd:pfam19440  10 YRLETEIERCRSECQWDKVPELVEQL----------------KAKR---IANDDMANLLLGEGKLEQYLKENPPILENST 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800    91 pllEKTDHRLNEAKDHLSSLLNNGKLPPQYMCEAMLILGKLHYVEGSYRDAVSMYARAGIDDISVENKPLYQMRLLSEAF 170
Cdd:pfam19440  71 ---EKNQPKLSEAKKHLTSALDRGNLKPEFLQEAHLLLAKLNYVEGDYREALNMYARAGLDDLTLKELPVYRLRLLAEAY 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800   171 VIKGLSLERLPNSVASHIRLTEREEEVVACFERASWVAQVFLQELEKTSNNSTSRHLKGSLSP-DYELSYFLEAALQSAY 249
Cdd:pfam19440 148 AIKGLCLEKQAVSSSSRVRLAEREEEMITCYEKAGDIALLYLQELERINSNTQNRSPKPGPPSqEQELGFFLETALQRAY 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800   250 VKNLKKGNIVKGMRELREILRTVETKATQNFKVVAAKHLAGVLLHSLSEDCYWSPLSHPLPEFMnKEENSFVTQT----- 324
Cdd:pfam19440 228 VLYFKKGNLARGVGRYREILRAVETRTTQNLRMTIARQLAEVLLRGVCEQSYWNPLEDPPPQSL-LDEPLKGTNTknytp 306

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800   325 LRKPHLYEGDNLYCPKDNIEEALLLLLISESMATRDVVLSRAPEQAEDRKVSLQNASAIYDLLSITLGRRGQYVMLSECL 404
Cdd:pfam19440 307 SRKPRVYSGENIFCPQDNVEEALLLLLISESMANRDAVLSRSPEHREARIISLQNATAVYDLLTIAMGRRGQYEMLSECL 386
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 710-849 1.07e-20

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 97.37  E-value: 1.07e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800 710 LEQIWLQAAELFMEQRQLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGSFEEAKQLYKEALTVNPDGVRIMHSLGLML 789
Cdd:COG3914  77 LAALLELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEAL 156

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800 790 SQLGHKSLAQKVLRDAVERQSTFHEAWQGLGEVLQDQGQNEAAVDCFLTALELEASSPVL 849
Cdd:COG3914 157 RRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADA 216
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
712-843 1.23e-17

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 83.13  E-value: 1.23e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800 712 QIWLQAAELFMEQRQLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGSFEEAKQLYKEALTVNPDGVRIMHSLGLMLSQ 791
Cdd:COG0457   9 EAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQA 88

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 30842800 792 LGHKSLAQKVLRDAVERQSTFHEAWQGLGEVLQDQGQNEAAVDCFLTALELE 843
Cdd:COG0457  89 LGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELD 140
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 712-844 2.84e-15

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 73.30  E-value: 2.84e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800 712 QIWLQAAELFMEQRQLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGSFEEAKQLYKEALTVNPDGVRIMHSLGLMLSQ 791
Cdd:COG4783   5 EALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLK 84

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 30842800 792 LGHKSLAQKVLRDAVERQSTFHEAWQGLGEVLQDQGQNEAAVDCFLTALELEA 844
Cdd:COG4783  85 AGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDP 137
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 711-849 3.09e-15

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 76.69  E-value: 3.09e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800 711 EQIWLQAAELFMEQRQLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGSFEEAKQLYKEALTVNPDGVRIMHSLGLMLS 790
Cdd:COG2956 110 AEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYL 189

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 30842800 791 QLGHKSLAQKVLRDAVERQSTFHEAWQGLGEVLQDQGQNEAAVDCFLTALELEASSPVL 849
Cdd:COG2956 190 EQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDLL 248
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 710-847 6.17e-14

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 75.80  E-value: 6.17e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800 710 LEQIWLQAAELFMEQRQLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGSFEEAKQLYKEALTVNPDGVRIMHSLGLML 789
Cdd:COG3914  43 LALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLL 122

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 30842800 790 SQLGHKSLAQKVLRDAVERQSTFHEAWQGLGEVLQDQGQNEAAVDCFLTALELEASSP 847
Cdd:COG3914 123 LALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNA 180
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
740-847 9.96e-14

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 71.96  E-value: 9.96e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800 740 LFPTSHSVLYMRGRLAEVKGSFEEAKQLYKEALTVNPDGVRIMHSLGLMLSQLGHKSLAQKVLRDAVERQSTFHEAWQGL 819
Cdd:COG0457   3 LDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNL 82

                        90       100
                ....*....|....*....|....*...
gi 30842800 820 GEVLQDQGQNEAAVDCFLTALELEASSP 847
Cdd:COG0457  83 GLALQALGRYEEALEDYDKALELDPDDA 110
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
712-844 1.32e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 71.58  E-value: 1.32e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800 712 QIWLQAAELFMEQRQLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGSFEEAKQLYKEALTVNPDGVRIMHSLGLMLSQ 791
Cdd:COG0457  43 EALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLE 122

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 30842800 792 LGHKSLAQKVLRDAVERQSTFHEAWQGLGEVLQDQGQNEAAVDCFLTALELEA 844
Cdd:COG0457 123 LGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAAL 175
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 711-843 4.98e-13

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 70.14  E-value: 4.98e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800 711 EQIWLQAAELFMEQRQLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGSFEEAKQLYKEALTVNPDGVRIMHSLGLMLS 790
Cdd:COG2956  76 AEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYL 155

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 30842800 791 QLGHKSLAQKVLRDAVERQSTFHEAWQGLGEVLQDQGQNEAAVDCFLTALELE 843
Cdd:COG2956 156 EQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQD 208
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 746-847 1.28e-12

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 65.98  E-value: 1.28e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800 746 SVLYMRGRLAEVKGSFEEAKQLYKEALTVNPDGVRIMHSLGLMLSQLGHKSLAQKVLRDAVERQSTFHEAWQGLGEVLQD 825
Cdd:COG4783   5 EALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLK 84

                        90       100
                ....*....|....*....|..
gi 30842800 826 QGQNEAAVDCFLTALELEASSP 847
Cdd:COG4783  85 AGDYDEALALLEKALKLDPEHP 106
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 711-841 3.21e-12

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 67.83  E-value: 3.21e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800 711 EQIWLQAAELFMEQRQLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGSFEEAKQLYKEALTVNPDGVRIMHSLGLMLS 790
Cdd:COG2956 144 AHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYE 223

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 30842800 791 QLGHKSLAQKVLRDAVERQSTfHEAWQGLGEVLQDQGQNEAAVDCFLTALE 841
Cdd:COG2956 224 KLGDPEEALELLRKALELDPS-DDLLLALADLLERKEGLEAALALLERQLR 273
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 729-842 2.42e-11

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 61.95  E-value: 2.42e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800 729 EAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGSFEEAKQLYKEALTVNPDGVRIMHSLGLMLSQLGHKSLAQKVLRDAVER 808
Cdd:COG4235   1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALAL 80

                        90       100       110
                ....*....|....*....|....*....|....
gi 30842800 809 QSTFHEAWQGLGEVLQDQGQNEAAVDCFLTALEL 842
Cdd:COG4235  81 DPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLAL 114
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 714-842 3.06e-11

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 64.75  E-value: 3.06e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800 714 WLQAAELFMEQRQLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGSFEEAKQLYKEALTVNPDGVRIMHSLGLMLSQLG 793
Cdd:COG2956  11 WYFKGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAG 90

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 30842800 794 HKSLAQKVLRDAVERQSTFHEAWQGLGEVLQDQGQNEAAVDCFLTALEL 842
Cdd:COG2956  91 LLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKL 139
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 758-843 1.05e-10

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 60.74  E-value: 1.05e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800 758 KGSFEEAKQLYKEALTVNPDGVRIMHSLGLMLSQLGHKSLAQKVLRDAVERQSTFHEAWQGLGEVLQDQGQNEAAVDCFL 837
Cdd:COG5010  67 LGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQ 146


                ....*.
gi 30842800 838 TALELE 843
Cdd:COG5010 147 RALGTS 152
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 712-855 2.13e-10

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 64.24  E-value: 2.13e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800 712 QIWLQAAELFMEQRQLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGSFEEAKQLYKEALTVNPDGVRIMHSLGLMLSQ 791
Cdd:COG3914 113 EALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQD 192

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 30842800 792 LGHKSLAQKVLRDAVERQSTFHEAWQGLGEVLQDQGQNEAAVDCFLTALELEASSPVL-PFSIIA 855
Cdd:COG3914 193 LGRLEEAIAAYRRALELDPDNADAHSNLLFALRQACDWEVYDRFEELLAALARGPSELsPFALLY 257
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
758-845 3.15e-10

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 57.49  E-value: 3.15e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800 758 KGSFEEAKQLYKEALTVNPDGVRIMHSLGLMLSQLGHKSLAQKvLRDAVERQSTFHEAWQGLGEVLQDQGQNEAAVDCFL 837
Cdd:COG3063   5 LGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELGDYDEALAYLE 83


                ....*...
gi 30842800 838 TALELEAS 845
Cdd:COG3063  84 RALELDPS 91
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 664-809 5.52e-10

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 58.82  E-value: 5.52e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800 664 LPDAHDADSGSRRASSIAASRLEEAMSELTLTTSVLKQGPMQLWTTLEQIWLQAAELFMEQRQLKEAGFCIQEAAGLFPT 743
Cdd:COG5010   7 FDRLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPN 86

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 30842800 744 SHSVLYMRGRLAEVKGSFEEAKQLYKEALTVNPDGVRIMHSLGLMLSQLGHKSLAQKVLRDAVERQ 809
Cdd:COG5010  87 NPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTS 152
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 712-847 2.13e-09

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 59.36  E-value: 2.13e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800 712 QIWLQAAELFMEQRQLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGSFEEAKQLYKEALTVNPDGVRIMHSLGLMLSQ 791
Cdd:COG2956  43 EAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQ 122

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 30842800 792 LGHKSLAQKVLRDAVERQSTFHEAWQGLGEVLQDQGQNEAAVDCFLTALELEASSP 847
Cdd:COG2956 123 EGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCA 178
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 749-847 3.07e-09

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 58.97  E-value: 3.07e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800 749 YMRGRLAEVKGSFEEAKQLYKEALTVNPDGVRIMHSLGLMLSQLGHKSLAQKVLRDAVERQSTFHEAWQGLGEVLQDQGQ 828
Cdd:COG2956  12 YFKGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGL 91

                        90
                ....*....|....*....
gi 30842800 829 NEAAVDCFLTALELEASSP 847
Cdd:COG2956  92 LDRAEELLEKLLELDPDDA 110
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 712-808 4.41e-09

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 55.40  E-value: 4.41e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800 712 QIWLQAAELFMEQRQLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGSFEEAKQLYKEALTVNPDGVRIMHSLGLMLSQ 791
Cdd:COG4235  18 EGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQ 97

                        90
                ....*....|....*..
gi 30842800 792 LGHKSLAQKVLRDAVER 808
Cdd:COG4235  98 QGDYAEAIAAWQKLLAL 114
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
720-814 1.58e-07

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 49.78  E-value: 1.58e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800 720 LFMEQRQLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGSFEEAKQlYKEALTVNPDGVRIMHSLGLMLSQLGHKSLAQ 799
Cdd:COG3063   1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELGDYDEAL 79

                        90
                ....*....|....*
gi 30842800 800 KVLRDAVERQSTFHE 814
Cdd:COG3063  80 AYLERALELDPSALR 94
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 605-843 2.02e-07

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 54.60  E-value: 2.02e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800   605 FTKVKLEQVLKGPEEALVTCRQMLRLWQTLYNFSQLGGLEKDGSFEGLTVKKQNGIHLTLPDAhDADSGSRRASSIAASR 684
Cdd:TIGR00990 242 FAESKAKEILETKPENLPSVTFVGNYLQSFRPKPRPAGLEDSNELDEETGNGQLQLGLKSPES-KADESYEEAARAFEKA 320

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800   685 LE-------EAMS-ELTLTTSVLKQGP----------MQLWTTLEQIWLQAAELFMEQRQLKEAGFCIQEAAGLFPTSHS 746
Cdd:TIGR00990 321 LDlgklgekEAIAlNLRGTFKCLKGKHlealadlsksIELDPRVTQSYIKRASMNLELGDPDKAEEDFDKALKLNSEDPD 400

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800   747 VLYMRGRLAEVKGSFEEAKQLYKEALTVNPDGVRIMHSLGLMLSQLGHKSLAQKVLRDAVERQSTFHEAWQGLGEVLQDQ 826
Cdd:TIGR00990 401 IYYHRAQLHFIKGEFAQAGKDYQKSIDLDPDFIFSHIQLGVTQYKEGSIASSMATFRRCKKNFPEAPDVYNYYGELLLDQ 480

                         250
                  ....*....|....*..
gi 30842800   827 GQNEAAVDCFLTALELE 843
Cdd:TIGR00990 481 NKFDEAIEKFDTAIELE 497
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
772-843 6.60e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 51.55  E-value: 6.60e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 30842800 772 LTVNPDGVRIMHSLGLMLSQLGHKSLAQKVLRDAVERQSTFHEAWQGLGEVLQDQGQNEAAVDCFLTALELE 843
Cdd:COG0457   1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELD 72
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 378-848 9.67e-07

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 52.78  E-value: 9.67e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800   378 QNASAIYDLLSITLGRRGQYVMLSECLERAMKCAFGEFHLWYQVALSMVACGKSAYAVSLLRECMKLQPSDPTVPLMAAk 457
Cdd:TIGR02917 360 PDDPAALSLLGEAYLALGDFEKAAEYLAKATELDPENAAARTQLGISKLSQGDPSEAIADLETAAQLDPELGRADLLLI- 438

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800   458 vcigsLHWLEEAEhfatvvIGLGEEAGESLPKGYLALGLTYSLQAtdATLKSKQDElhRKALQTLERARELAPDDPQIIF 537
Cdd:TIGR02917 439 -----LSYLRSGQ------FDKALAAAKKLEKKQPDNASLHNLLG--AIYLGKGDL--AKAREAFEKALSIEPDFFPAAA 503

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800   538 YVALQLALVRQISSAMERLQEALTMCRDDANALHLLALLFSAQKYYQHALDVINMAITEHPENFNL-------MFTKVKL 610
Cdd:TIGR02917 504 NLARIDIQEGNPDDAIQRFEKVLTIDPKNLRAILALAGLYLRTGNEEEAVAWLEKAAELNPQEIEPalalaqyYLGKGQL 583

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800   611 EQVLKGPEEALVTCRQMLRLWQTLYNFSQLGGLEKDG--SFEGLTvkKQNG----IHLTLPDAHDADSGSRRAssiaasr 684
Cdd:TIGR02917 584 KKALAILNEAADAAPDSPEAWLMLGRAQLAAGDLNKAvsSFKKLL--ALQPdsalALLLLADAYAVMKNYAKA------- 654

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800   685 LEEAMSELTLTTSVLKQGPMQlwttleqiwlqaAELFMEQRQLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGSFEEA 764
Cdd:TIGR02917 655 ITSLKRALELKPDNTEAQIGL------------AQLLLAAKRTESAKKIAKSLQKQHPKAALGFELEGDLYLRQKDYPAA 722

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800   765 KQLYKEALTVNPDGVRIMHsLGLMLSQLGHKSLAQKVLRDAVERQSTFHEAWQGLGEVLQDQGQNEAAVDCFLTALELEA 844
Cdd:TIGR02917 723 IQAYRKALKRAPSSQNAIK-LHRALLASGNTAEAVKTLEAWLKTHPNDAVLRTALAELYLAQKDYDKAIKHYQTVVKKAP 801


                  ....
gi 30842800   845 SSPV 848
Cdd:TIGR02917 802 DNAV 805
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
705-841 1.48e-06

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 49.91  E-value: 1.48e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800 705 QLWTTLEQIWLQAAELFMEQRQLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGSFEEAKQLYKEALTVNPDGVRIMHS 784
Cdd:COG4785  67 LALPDLAQLYYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLN 146

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 30842800 785 LGLMLSQLGHKSLAQKVLRDAVERQSTFHEA--WQGL------------------GEVLQDQGQNEAAVDCFLTALE 841
Cdd:COG4785 147 RGIALYYLGRYELAIADLEKALELDPNDPERalWLYLaerkldpekalallledwATAYLLQGDTEEARELFKLALA 223
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
748-858 1.32e-05

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 47.22  E-value: 1.32e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800 748 LYMRGRLAEVKGSFEEAKQLYKEALTVNPDGVRIMHSLGLMLSQLGHKSLAQKVLRDAVERQSTFHEAWQGLGEVLQDQG 827
Cdd:COG4785  76 YYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYLG 155

                        90       100       110
                ....*....|....*....|....*....|.
gi 30842800 828 QNEAAVDCFLTALELeasSPVLPFSIIAREL 858
Cdd:COG4785 156 RYELAIADLEKALEL---DPNDPERALWLYL 183
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 763-847 1.66e-05

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 45.00  E-value: 1.66e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800 763 EAKQLYKEALTVNPDGVRIMHSLGLMLSQLGHKSLAQKVLRDAVERQSTFHEAWQGLGEVLQDQGQNEAAVDCFLTALEL 842
Cdd:COG4235   1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALAL 80


                ....*
gi 30842800 843 EASSP 847
Cdd:COG4235  81 DPDNP 85
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 492-809 1.88e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 47.42  E-value: 1.88e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800 492 LALGLTYSLQATDATLKSKQDelhrKALQTLERARELAPDDPQIIFYVAlQLALVR-QISSAMERLQEALTMCRDDANAL 570
Cdd:COG2956   5 VAAALGWYFKGLNYLLNGQPD----KAIDLLEEALELDPETVEAHLALG-NLYRRRgEYDRAIRIHQKLLERDPDRAEAL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800 571 HLLALLFSAQKYYQHALDVINMAITEHPENFNLMFTKVKLEQVLKGPEEALVTCRQMLRLWQTLYNFS-QLGGLEkdgsf 649
Cdd:COG2956  80 LELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYcELAELY----- 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800 650 egltvkkqngihltlpdahdadsgsrrassIAASRLEEAMSELTlttSVLKQGPmqlwtTLEQIWLQAAELFMEQRQLKE 729
Cdd:COG2956 155 ------------------------------LEQGDYDEAIEALE---KALKLDP-----DCARALLLLAELYLEQGDYEE 196

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800 730 AGFCIQEAAGLFPTSHSVLYMRGRLAEVKGSFEEAKQLYKEALTVNPDgVRIMHSLGLMLSQLGHKSLAQKVLRDAVERQ 809
Cdd:COG2956 197 AIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPS-DDLLLALADLLERKEGLEAALALLERQLRRH 275
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 393-851 2.63e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 48.16  E-value: 2.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800   393 RRGQYVMLSECLERAMKCAFGEFHLWYQVALSMVACGKSAYAVSLLRECMKLQPSDPTVPLMAAKVCIGSLHWLEeaehf 472
Cdd:TIGR02917 273 QKKNYEDARETLQDALKSAPEYLPALLLAGASEYQLGNLEQAYQYLNQILKYAPNSHQARRLLASIQLRLGRVDE----- 347

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800   473 ATVVIGLGEEAGESLPKGYLALGLTYsLQATDATlkskqdelhrKALQTLERARELAPDDPQiifyVALQLALVR----Q 548
Cdd:TIGR02917 348 AIATLSPALGLDPDDPAALSLLGEAY-LALGDFE----------KAAEYLAKATELDPENAA----ARTQLGISKlsqgD 412

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800   549 ISSAMERLQEALTMCRDDANALHLLALLFSAQKYYQHALDVINMAITEHPEN---FNLMFTKVKLEQVLKGPEEALvtcR 625
Cdd:TIGR02917 413 PSEAIADLETAAQLDPELGRADLLLILSYLRSGQFDKALAAAKKLEKKQPDNaslHNLLGAIYLGKGDLAKAREAF---E 489

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800   626 QMLRLWQTlyNFSQLGGLEKdgsfegLTVKKQNgihltLPDAHD-------ADSGSRRA----SSIAASRLEEAMSELTL 694
Cdd:TIGR02917 490 KALSIEPD--FFPAAANLAR------IDIQEGN-----PDDAIQrfekvltIDPKNLRAilalAGLYLRTGNEEEAVAWL 556

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800   695 TTsvlkqgPMQLWTTLEQIWLQAAELFMEQRQLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGSFEEAKQLYKEALTV 774
Cdd:TIGR02917 557 EK------AAELNPQEIEPALALAQYYLGKGQLKKALAILNEAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSFKKLLAL 630

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 30842800   775 NPDGVRIMHSLGLMLSQLGHKSLAQKVLRDAVERQSTFHEAWQGLGEVLQDQGQNEAAvdcFLTALELEASSPVLPF 851
Cdd:TIGR02917 631 QPDSALALLLLADAYAVMKNYAKAITSLKRALELKPDNTEAQIGLAQLLLAAKRTESA---KKIAKSLQKQHPKAAL 704
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 711-843 2.76e-05

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 47.68  E-value: 2.76e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800 711 EQIWLQAAELFMEQRQLKEAGFCIQEAAGLFPT---------SHSVLYMRGRLAEVKGSFEEAKQLYKEALTVNPDGVRI 781
Cdd:COG3914   1 AAAAALLALAALAAAALLAAAAAAELALAAELEaaalaaalgLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAAL 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 30842800 782 MHSLGLMLSQLGHKSLAQKVLRDAVERQSTFHEAWQGLGEVLQDQGQNEAAVDCFLTALELE 843
Cdd:COG3914  81 LELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALN 142
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 715-840 4.20e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 47.39  E-value: 4.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800   715 LQAAELFMEQRQLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGSFEEAKQLYKEALTVNPDGVRIMHSLGLMLSQLGH 794
Cdd:TIGR02917 163 LGLAQLALAENRFDEARALIDEVLTADPGNVDALLLKGDLLLSLGNIELALAAYRKAIALRPNNIAVLLALATILIEAGE 242

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 30842800   795 KSLAQKVLRDAVER--QSTFHEAWQGLGEVlqDQGQNEAAVDCFLTAL 840
Cdd:TIGR02917 243 FEEAEKHADALLKKapNSPLAHYLKALVDF--QKKNYEDARETLQDAL 288
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 515-630 5.24e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 44.03  E-value: 5.24e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800 515 HRKALQTLERARELAPDDPQIIFYVALQLALVRQISSAMERLQEALTMCRDDANALHLLALLFSAQKYYQHALDVINMAI 594
Cdd:COG4783  20 YDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKAL 99

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 30842800 595 TEHPENFNLMFTKVKLEQVLKGPEEALVTCRQMLRL 630
Cdd:COG4783 100 KLDPEHPEAYLRLARAYRALGRPDEAIAALEKALEL 135
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 712-778 6.76e-05

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 43.46  E-value: 6.76e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 30842800 712 QIWLQAAELFMEQRQLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGSFEEAKQLYKEALTVNPDG 778
Cdd:COG4235  52 DALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLPAD 118
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 779-847 6.98e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 43.64  E-value: 6.98e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 30842800 779 VRIMHSLGLMLSQLGHKSLAQKVLRDAVERQSTFHEAWQGLGEVLQDQGQNEAAVDCFLTALELEASSP 847
Cdd:COG4783   4 AEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEP 72
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 418-630 1.54e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 44.33  E-value: 1.54e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800 418 WYQVALSMVACGKSAYAVSLLRECMKLQPSDPtvplmAAKVCIGSLHW----LEEAEHFATVVIGLGEEAgeslPKGYLA 493
Cdd:COG2956  11 WYFKGLNYLLNGQPDKAIDLLEEALELDPETV-----EAHLALGNLYRrrgeYDRAIRIHQKLLERDPDR----AEALLE 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800 494 LGLTY--------------SLQATDATLKSKQDEL---------HRKALQTLERARELAPDDPQIIFYVALQLALVRQIS 550
Cdd:COG2956  82 LAQDYlkaglldraeelleKLLELDPDDAEALRLLaeiyeqegdWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYD 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800 551 SAMERLQEALTMCRDDANALHLLALLFSAQKYYQHALDVINMAITEHPENFNLMFTKVKLEQVLKGPEEALVTCRQMLRL 630
Cdd:COG2956 162 EAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALEL 241
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
491-626 3.32e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 43.07  E-value: 3.32e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800 491 YLALGLTYSLQatdatlkskqdELHRKALQTLERARELAPDDPQIIFYVALQLALVRQISSAMERLQEALTMCRDDANAL 570
Cdd:COG0457  45 LYNLGLAYLRL-----------GRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEAL 113

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 30842800 571 HLLALLFSAQKYYQHALDVINMAITEHPENFNLMFTKVKLEQVLKGPEEALVTCRQ 626
Cdd:COG0457 114 YNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEK 169
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 721-808 3.78e-04

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 40.75  E-value: 3.78e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800 721 FMEQRQLKEAGFCIQEAAGLFPTSH---SVLYMRGRLAEVKGSFEEAKQLYKEALTVNPDGVRI---MHSLGLMLSQLGH 794
Cdd:COG1729   3 LLKAGDYDEAIAAFKAFLKRYPNSPlapDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPKApdaLLKLGLSYLELGD 82

                        90
                ....*....|....
gi 30842800 795 KSLAQKVLRDAVER 808
Cdd:COG1729  83 YDKARATLEELIKK 96
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 393-629 4.34e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 43.18  E-value: 4.34e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800 393 RRGQYVMLSECLERAMKCAFGEFHLWYQVALSMVACGKSAYAVSLLRECMKLQPSDPTVPLMAAKVCIGSLHWlEEAEHF 472
Cdd:COG2956  54 RRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDW-EKAIEV 132

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800 473 ATVVIGLGEEAgeslPKGYLALGLTYslqatdatLKSKQDElhrKALQTLERARELAPDDPQIIFYVALQLALVRQISSA 552
Cdd:COG2956 133 LERLLKLGPEN----AHAYCELAELY--------LEQGDYD---EAIEALEKALKLDPDCARALLLLAELYLEQGDYEEA 197

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 30842800 553 MERLQEALTMCRDDANALHLLALLFSAQKYYQHALDVINMAITEHPENfNLMFTKVKLEQVLKGPEEALVTCRQMLR 629
Cdd:COG2956 198 IAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSD-DLLLALADLLERKEGLEAALALLERQLR 273
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 515-598 7.27e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 41.10  E-value: 7.27e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800 515 HRKALQTLERARELAPDDPQIIFYVALQLALVRQISSAMERLQEALTMCRDDANALHLLALLFSAQKYYQHALDVINMAI 594
Cdd:COG5010  70 FEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRAL 149


                ....
gi 30842800 595 TEHP 598
Cdd:COG5010 150 GTSP 153
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
384-560 1.11e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 41.53  E-value: 1.11e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800 384 YDLLSITLGRRGQYVMLSECLERAMKCAFGEFHLWYQVALSMVACGKSAYAVSLLRECMKLQPSDPTVPLMAAKVCIgSL 463
Cdd:COG0457  11 YNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQ-AL 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800 464 HWLEEA-EHFATVViglgeEAGESLPKGYLALGLTYSLQatdatlkskqdELHRKALQTLERARELAPDDPQIIFYVALQ 542
Cdd:COG0457  90 GRYEEAlEDYDKAL-----ELDPDDAEALYNLGLALLEL-----------GRYDEAIEAYERALELDPDDADALYNLGIA 153

                       170
                ....*....|....*...
gi 30842800 543 LALVRQISSAMERLQEAL 560
Cdd:COG0457 154 LEKLGRYEEALELLEKLE 171
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 762-848 1.55e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 39.94  E-value: 1.55e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800 762 EEAKQLYKEALTVNPDGVRIMHSLGLMLSQLGHKSLAQKVLRDAVERQSTFHEAWQGLGEVLQDQGQNEAAVDCFLTALE 841
Cdd:COG5010  37 TKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALA 116


                ....*..
gi 30842800 842 LEASSPV 848
Cdd:COG5010 117 LSPDNPN 123
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 747-842 1.85e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 41.99  E-value: 1.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800   747 VLYMRGRLAEVKGSFEEAKQLYKEALTVNPDgvRIMHSLGLMLSQLGHKSL--AQKVLRDAVERQSTFHEAWQGLGEVLQ 824
Cdd:TIGR02917 127 LLALRGLAYLGLGQLELAQKSYEQALAIDPR--SLYAKLGLAQLALAENRFdeARALIDEVLTADPGNVDALLLKGDLLL 204

                          90
                  ....*....|....*...
gi 30842800   825 DQGQNEAAVDCFLTALEL 842
Cdd:TIGR02917 205 SLGNIELALAAYRKAIAL 222
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 517-600 2.27e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 39.02  E-value: 2.27e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800 517 KALQTLERARELAPDDPQIIFYVALQLALVRQISSAMERLQEALTMCRDDANALHLLALLFSAQKYYQHALDVINMAITE 596
Cdd:COG4783  56 EAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALEL 135


                ....
gi 30842800 597 HPEN 600
Cdd:COG4783 136 DPDD 139
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 378-473 2.85e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 39.02  E-value: 2.85e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800 378 QNASAiYDLLSITLGRRGQYVMLSECLERAMKCAFGEFHLWYQVALSMVACGKSAYAVSLLRECMKLQPSDPTVPLMAAK 457
Cdd:COG4783  36 DNPEA-FALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLAR 114

                        90
                ....*....|....*.
gi 30842800 458 VCIGSLHWLEEAEHFA 473
Cdd:COG4783 115 AYRALGRPDEAIAALE 130
TPR_11 pfam13414
TPR repeat;
758-793 3.71e-03

TPR repeat;


Pssm-ID: 315977 [Multi-domain]  Cd Length: 42  Bit Score: 35.91  E-value: 3.71e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 30842800   758 KGSFEEAKQLYKEALTVNPDGVRIMHSLGLMLSQLG 793
Cdd:pfam13414   7 QGKYEEAIEAYKKALKLDPDNPEAYYNLGLAYYKLG 42
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 758-847 4.21e-03

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 37.66  E-value: 4.21e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800 758 KGSFEEAKQLYKEALTVNPDGV---RIMHSLGLMLSQLGHKSLAQKVLRDAVER--QSTFH-EAWQGLGEVLQDQGQNEA 831
Cdd:COG1729   6 AGDYDEAIAAFKAFLKRYPNSPlapDALYWLGEAYYALGDYDEAAEAFEKLLKRypDSPKApDALLKLGLSYLELGDYDK 85

                        90
                ....*....|....*.
gi 30842800 832 AVDCFLTALELEASSP 847
Cdd:COG1729  86 ARATLEELIKKYPDSE 101
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 488-612 4.75e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 38.06  E-value: 4.75e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800 488 PKGYLALGLTYSLQatdatlkskqdELHRKALQTLERARELAPDDPQIIFYVALQLALVRQISSAMERLQEALTMCRDDA 567
Cdd:COG4235  17 AEGWLLLGRAYLRL-----------GRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNP 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 30842800 568 NALHLLALLFSAQKYYQHALDVINMAITEHPENFNLMFTKVKLEQ 612
Cdd:COG4235  86 EALYLLGLAAFQQGDYAEAIAAWQKLLALLPADAPARLLEASIAE 130
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 712-777 6.06e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 37.86  E-value: 6.06e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 30842800 712 QIWLQAAELFMEQRQLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGSFEEAKQLYKEALTVNPD 777
Cdd:COG4783  73 EARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPD 138
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 482-639 7.39e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 39.98  E-value: 7.39e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800 482 EAGESLPKGYLALGLTYSLQatdatlkskqdELHRKALQTLERARELAPDDPQIIFYVALQLALVRQISSAMERLQEALT 561
Cdd:COG3914 106 ALNPDNAEALFNLGNLLLAL-----------GRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALE 174

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30842800 562 MCRDDANALHLLALLFSAQKYYQHALDVINMAITEHPENF----NLMFTKVKLE--QVLKGPEEALVTCRQMLRLWQTLY 635
Cdd:COG3914 175 LDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNAdahsNLLFALRQACdwEVYDRFEELLAALARGPSELSPFA 254


                ....
gi 30842800 636 NFSQ 639
Cdd:COG3914 255 LLYL 258
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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