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Conserved domains on  [gi|254675129|ref|NP_082940|]
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ankyrin repeat domain-containing protein 45 isoform 1 [Mus musculus]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
96-241 5.31e-16

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 76.15  E-value: 5.31e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675129  96 HEHAVQLLLE-------EDIVGRNLLYAACMAGKSDVIKALAKYGVNLNEATARGYTLLHCAAAWGRLETLKALVELDVD 168
Cdd:COG0666  132 NLEIVKLLLEagadvnaQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGAD 211

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 254675129 169 IEALNFRGEKARDVAARYSQVECVNFLDWADARLILKKIITKSSLIITDPEKGPGKLFKEDKSTILNACRLKN 241
Cdd:COG0666  212 VNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLD 284
PTZ00009 super family cl36495
heat shock 70 kDa protein; Provisional
 219-273 8.03e-05

heat shock 70 kDa protein; Provisional


The actual alignment was detected with superfamily member PTZ00009:

Pssm-ID: 240227 [Multi-domain]  Cd Length: 653  Bit Score: 44.02  E-value: 8.03e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 254675129 219 EKGPGKLFKEDKSTILNACRLKNEWLESHPEASISEiFEQKQ-QLEDIVSPILAKM 273
Cdd:PTZ00009 558 EKVKGKLSDSDKATIEKAIDEALEWLEKNQLAEKEE-FEHKQkEVESVCNPIMTKM 612
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
96-241 5.31e-16

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 76.15  E-value: 5.31e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675129  96 HEHAVQLLLE-------EDIVGRNLLYAACMAGKSDVIKALAKYGVNLNEATARGYTLLHCAAAWGRLETLKALVELDVD 168
Cdd:COG0666  132 NLEIVKLLLEagadvnaQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGAD 211

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 254675129 169 IEALNFRGEKARDVAARYSQVECVNFLDWADARLILKKIITKSSLIITDPEKGPGKLFKEDKSTILNACRLKN 241
Cdd:COG0666  212 VNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLD 284
Ank_2 pfam12796
Ankyrin repeats (3 copies);
96-173 4.06e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 58.20  E-value: 4.06e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675129   96 HEHAVQLLLEE-------DIVGRNLLYAACMAGKSDVIKALAKYgVNLNEATaRGYTLLHCAAAWGRLETLKALVELDVD 168
Cdd:pfam12796   9 NLELVKLLLENgadanlqDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVKLLLEKGAD 86


                  ....*
gi 254675129  169 IEALN 173
Cdd:pfam12796  87 INVKD 91
PTZ00009 PTZ00009
heat shock 70 kDa protein; Provisional
 219-273 8.03e-05

heat shock 70 kDa protein; Provisional


Pssm-ID: 240227 [Multi-domain]  Cd Length: 653  Bit Score: 44.02  E-value: 8.03e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 254675129 219 EKGPGKLFKEDKSTILNACRLKNEWLESHPEASISEiFEQKQ-QLEDIVSPILAKM 273
Cdd:PTZ00009 558 EKVKGKLSDSDKATIEKAIDEALEWLEKNQLAEKEE-FEHKQkEVESVCNPIMTKM 612
PHA03095 PHA03095
ankyrin-like protein; Provisional
 103-186 4.04e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 41.55  E-value: 4.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675129 103 LLEEDIVGRNLLYAaCMAGKS---DVIKALAKYGVNLNEATARGYTLLHCAAAWGR--LETLKALVELDVDIEALNFRGE 177
Cdd:PHA03095 110 VNAKDKVGRTPLHV-YLSGFNinpKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNanVELLRLLIDAGADVYAVDDRFR 188


                 ....*....
gi 254675129 178 KARDVAARY 186
Cdd:PHA03095 189 SLLHHHLQS 197
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 142-171 1.50e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 35.26  E-value: 1.50e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 254675129   142 RGYTLLHCAAAWGRLETLKALVELDVDIEA 171
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
96-241 5.31e-16

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 76.15  E-value: 5.31e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675129  96 HEHAVQLLLE-------EDIVGRNLLYAACMAGKSDVIKALAKYGVNLNEATARGYTLLHCAAAWGRLETLKALVELDVD 168
Cdd:COG0666  132 NLEIVKLLLEagadvnaQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGAD 211

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 254675129 169 IEALNFRGEKARDVAARYSQVECVNFLDWADARLILKKIITKSSLIITDPEKGPGKLFKEDKSTILNACRLKN 241
Cdd:COG0666  212 VNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLD 284
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
96-195 1.03e-14

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 72.68  E-value: 1.03e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675129  96 HEHAVQLLLEE-------DIVGRNLLYAACMAGKSDVIKALAKYGVNLNEATARGYTLLHCAAAWGRLETLKALVELDVD 168
Cdd:COG0666   99 DLEIVKLLLEAgadvnarDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGAD 178

                         90       100
                 ....*....|....*....|....*..
gi 254675129 169 IEALNFRGEKARDVAARYSQVECVNFL 195
Cdd:COG0666  179 VNARDNDGETPLHLAAENGHLEIVKLL 205
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
110-195 2.34e-12

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 65.75  E-value: 2.34e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675129 110 GRNLLYAACMAGKSDVIKALAKYGVNLNEATARGYTLLHCAAAWGRLETLKALVELDVDIEALNFRGEKARDVAARYSQV 189
Cdd:COG0666   87 GNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNL 166


                 ....*.
gi 254675129 190 ECVNFL 195
Cdd:COG0666  167 EIVKLL 172
Ank_2 pfam12796
Ankyrin repeats (3 copies);
96-173 4.06e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 58.20  E-value: 4.06e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675129   96 HEHAVQLLLEE-------DIVGRNLLYAACMAGKSDVIKALAKYgVNLNEATaRGYTLLHCAAAWGRLETLKALVELDVD 168
Cdd:pfam12796   9 NLELVKLLLENgadanlqDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVKLLLEKGAD 86


                  ....*
gi 254675129  169 IEALN 173
Cdd:pfam12796  87 INVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
114-195 1.24e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 57.05  E-value: 1.24e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675129  114 LYAACMAGKSDVIKALAKYGVNLNEATARGYTLLHCAAAWGRLETLKALVE-LDVDIealNFRGEKARDVAARYSQVECV 192
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEhADVNL---KDNGRTALHYAARSGHLEIV 77


                  ...
gi 254675129  193 NFL 195
Cdd:pfam12796  78 KLL 80
Ank_4 pfam13637
Ankyrin repeats (many copies);
110-163 9.17e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 50.74  E-value: 9.17e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 254675129  110 GRNLLYAACMAGKSDVIKALAKYGVNLNEATARGYTLLHCAAAWGRLETLKALV 163
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
102-195 1.04e-08

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 54.96  E-value: 1.04e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675129 102 LLLEEDIVGRNLLYAACMAGKSDVIKALAKYGVNLNEATARGYTLLHCAAAWGRLETLKALVELDVDIEALNFRGEKARD 181
Cdd:COG0666   46 ALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLH 125

                         90
                 ....*....|....
gi 254675129 182 VAARYSQVECVNFL 195
Cdd:COG0666  126 LAAYNGNLEIVKLL 139
Ank_4 pfam13637
Ankyrin repeats (many copies);
143-195 7.55e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 45.34  E-value: 7.55e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 254675129  143 GYTLLHCAAAWGRLETLKALVELDVDIEALNFRGEKARDVAARYSQVECVNFL 195
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
PTZ00009 PTZ00009
heat shock 70 kDa protein; Provisional
 219-273 8.03e-05

heat shock 70 kDa protein; Provisional


Pssm-ID: 240227 [Multi-domain]  Cd Length: 653  Bit Score: 44.02  E-value: 8.03e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 254675129 219 EKGPGKLFKEDKSTILNACRLKNEWLESHPEASISEiFEQKQ-QLEDIVSPILAKM 273
Cdd:PTZ00009 558 EKVKGKLSDSDKATIEKAIDEALEWLEKNQLAEKEE-FEHKQkEVESVCNPIMTKM 612
PHA03095 PHA03095
ankyrin-like protein; Provisional
 103-186 4.04e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 41.55  E-value: 4.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675129 103 LLEEDIVGRNLLYAaCMAGKS---DVIKALAKYGVNLNEATARGYTLLHCAAAWGR--LETLKALVELDVDIEALNFRGE 177
Cdd:PHA03095 110 VNAKDKVGRTPLHV-YLSGFNinpKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNanVELLRLLIDAGADVYAVDDRFR 188


                 ....*....
gi 254675129 178 KARDVAARY 186
Cdd:PHA03095 189 SLLHHHLQS 197
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 124-195 4.18e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 41.57  E-value: 4.18e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 254675129 124 DVIKALAKYGVNLNEATARGYTLLHCAAAWGRLETLKALVELDVDIEALNFRGEKARDVAARYSQVECVNFL 195
Cdd:PHA03100 173 NRVNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLL 244
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 142-171 5.64e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 36.47  E-value: 5.64e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 254675129  142 RGYTLLHCAAAWGRLETLKALVELDVDIEA 171
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 142-171 1.50e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 35.26  E-value: 1.50e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 254675129   142 RGYTLLHCAAAWGRLETLKALVELDVDIEA 171
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
PHA03095 PHA03095
ankyrin-like protein; Provisional
 124-213 1.76e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 39.62  E-value: 1.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675129 124 DVIKALAKYGVNLNEATARGYTLLH--CAAAWGRLETLKALVELDVDIEALNFRGEKARDVAARYSQ--VECVNFLDWAD 199
Cdd:PHA03095  98 DVIKLLIKAGADVNAKDKVGRTPLHvyLSGFNINPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNanVELLRLLIDAG 177

                         90
                 ....*....|....
gi 254675129 200 ARLILKKIITKSSL 213
Cdd:PHA03095 178 ADVYAVDDRFRSLL 191
Ank_5 pfam13857
Ankyrin repeats (many copies);
129-183 4.32e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 34.63  E-value: 4.32e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 254675129  129 LAKYGVNLNEATARGYTLLHCAAAWGRLETLKALVELDVDIEALNFRGEKARDVA 183
Cdd:pfam13857   2 LEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 111-195 9.90e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 37.25  E-value: 9.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675129 111 RNLLYAACMAGKSDVIKALAKYGVNLNEATARGYTLLHCAAAWGRLETLKALVELDVDIEALNFRGEKARDVAARYSQVE 190
Cdd:PHA02874 125 KTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYA 204


                 ....*
gi 254675129 191 CVNFL 195
Cdd:PHA02874 205 CIKLL 209
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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