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Conserved domains on  [gi|125858598|ref|NP_083287|]
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pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 [Mus musculus]

Protein Classification

phytoene desaturase family protein( domain architecture ID 11440907)

phytoene desaturase family protein is an NAD(P)/FAD-dependent oxidoreductase that catalyzes the transfer of electrons from one molecule, the electron donor or reductant, to another molecule, the electron acceptor or oxidant; similar to phytoene desaturase, which converts phytoene into 3,4-didehydrolycopene via several intermediates by introducing up to five double bonds into phytoene

CATH:  3.50.50.60
EC:  1.-.-.-
Gene Ontology:  GO:0016491|GO:0009055|GO:0016117|GO:0016116

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG1233 COG1233
Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and ...
 35-579 9.28e-127

Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism];


:

Pssm-ID: 440846 [Multi-domain]  Cd Length: 491  Bit Score: 381.12  E-value: 9.28e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598  35 YDAVVIGAGHNGLVAAAYLQRLGVNTAVFERRHVIGGAAVTEEIiPGFKFSRASYLLSLLRP--QICTDLELKKHgLKLH 112
Cdd:COG1233    4 YDVVVIGAGIGGLAAAALLARAGYRVTVLEKNDTPGGRARTFER-PGFRFDVGPSVLTMPGVleRLFRELGLEDY-LELV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598 113 LRDPySFTPMLEEGtlnrlpRSLLLGTDMAANQKEISQFSRKDAQAFPRYEEFMKRLVLAIDPLLDAAPvdttafqhgsl 192
Cdd:COG1233   82 PLDP-AYRVPFPDG------RALDLPRDLERTAAELERLFPGDAEAYRRFLAELRRLYDALLEDLLYRP----------- 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598 193 lqrlraLSTLKPLLKAgrtlgAQLPQYYEVLTAPISKVLDQRFESEPLKATLATdavIGAMTSPHTPGSGYVLlhHVMGS 272
Cdd:COG1233  144 ------LLSLRDLLRP-----LALARLLRLLLRSLRDLLRRYFKDPRLRALLAG---QALYLGLSPDRTPALY--ALIAY 207

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598 273 LEGTQGAWsYVQGGMGALSDAIASSAATRGASIFTEKTVAKVQVnSEGRAQGVTLQDGEEVRSRVVLSCASPQVTFLELT 352
Cdd:COG1233  208 LEYAGGVW-YPKGGMGALADALARLAEELGGEIRTGAEVERILV-EGGRATGVRLADGEEIRADAVVSNADPAHTYLRLL 285

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598 353 PQEWLPGAFVKRISQLDTQSPVTKINVAVDR-LPNFqaapnapgdqpqGHHQcsIHLNcEDtllLHQAFEDAKGGLPSQK 431
Cdd:COG1233  286 GEEALPARYRRRLERFRYSPSAFKLYLGLDGpLPGL------------AHHT--IHLS-ED---YEAAFDDIFRGRLPED 347

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598 432 PMIELCIPSSLDPTLAPPGCHVVSLFTQyTPYTLagGKVWnEQEKNTYADKVFDCIEAYAPGFKRSVLARDILTPPDLER 511
Cdd:COG1233  348 PSLYVSIPSLTDPSLAPEGKHTLWVLVP-VPYGL--EDAW-DELKEEYAERILARLERYAPGLRDRIVAREVLTPLDFER 423

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598 512 IFRLPGGNIFHGAMSLDQLYFARPvpqhSDYRCPVQGLYLCGSGAHPGGGVMGAA--GRNAAHVVFRDLK 579
Cdd:COG1233  424 YLNLVGGAIYGGAHTLDQSAFFRP----SNYRTPIPGLYLVGASTHPGGGVPGVLisGRLAARRILKDLK 489
FAD_binding_2 super family cl46878
FAD binding domain; This family includes members that bind FAD. This family includes the ...
 5-61 6.49e-03

FAD binding domain; This family includes members that bind FAD. This family includes the flavoprotein subunits from succinate and fumarate dehydrogenase, aspartate oxidase and the alpha subunit of adenylylsulphate reductase.


The actual alignment was detected with superfamily member PTZ00139:

Pssm-ID: 481218 [Multi-domain]  Cd Length: 617  Bit Score: 39.34  E-value: 6.49e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 125858598   5 GRGLIRALHSSPCPTwKRAQSGANGRLKPEYDAVVIGAGHNGLVAAAYLQRLGVNTA 61
Cdd:PTZ00139   1 RFAVPAFNRLTRTFF-SGHLSSAYPVIDHTYDAVVVGAGGAGLRAALGLVELGYKTA 56
 
Name Accession Description Interval E-value
COG1233 COG1233
Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and ...
 35-579 9.28e-127

Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440846 [Multi-domain]  Cd Length: 491  Bit Score: 381.12  E-value: 9.28e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598  35 YDAVVIGAGHNGLVAAAYLQRLGVNTAVFERRHVIGGAAVTEEIiPGFKFSRASYLLSLLRP--QICTDLELKKHgLKLH 112
Cdd:COG1233    4 YDVVVIGAGIGGLAAAALLARAGYRVTVLEKNDTPGGRARTFER-PGFRFDVGPSVLTMPGVleRLFRELGLEDY-LELV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598 113 LRDPySFTPMLEEGtlnrlpRSLLLGTDMAANQKEISQFSRKDAQAFPRYEEFMKRLVLAIDPLLDAAPvdttafqhgsl 192
Cdd:COG1233   82 PLDP-AYRVPFPDG------RALDLPRDLERTAAELERLFPGDAEAYRRFLAELRRLYDALLEDLLYRP----------- 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598 193 lqrlraLSTLKPLLKAgrtlgAQLPQYYEVLTAPISKVLDQRFESEPLKATLATdavIGAMTSPHTPGSGYVLlhHVMGS 272
Cdd:COG1233  144 ------LLSLRDLLRP-----LALARLLRLLLRSLRDLLRRYFKDPRLRALLAG---QALYLGLSPDRTPALY--ALIAY 207

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598 273 LEGTQGAWsYVQGGMGALSDAIASSAATRGASIFTEKTVAKVQVnSEGRAQGVTLQDGEEVRSRVVLSCASPQVTFLELT 352
Cdd:COG1233  208 LEYAGGVW-YPKGGMGALADALARLAEELGGEIRTGAEVERILV-EGGRATGVRLADGEEIRADAVVSNADPAHTYLRLL 285

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598 353 PQEWLPGAFVKRISQLDTQSPVTKINVAVDR-LPNFqaapnapgdqpqGHHQcsIHLNcEDtllLHQAFEDAKGGLPSQK 431
Cdd:COG1233  286 GEEALPARYRRRLERFRYSPSAFKLYLGLDGpLPGL------------AHHT--IHLS-ED---YEAAFDDIFRGRLPED 347

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598 432 PMIELCIPSSLDPTLAPPGCHVVSLFTQyTPYTLagGKVWnEQEKNTYADKVFDCIEAYAPGFKRSVLARDILTPPDLER 511
Cdd:COG1233  348 PSLYVSIPSLTDPSLAPEGKHTLWVLVP-VPYGL--EDAW-DELKEEYAERILARLERYAPGLRDRIVAREVLTPLDFER 423

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598 512 IFRLPGGNIFHGAMSLDQLYFARPvpqhSDYRCPVQGLYLCGSGAHPGGGVMGAA--GRNAAHVVFRDLK 579
Cdd:COG1233  424 YLNLVGGAIYGGAHTLDQSAFFRP----SNYRTPIPGLYLVGASTHPGGGVPGVLisGRLAARRILKDLK 489
crtI_fam TIGR02734
phytoene desaturase; Phytoene is converted to lycopene by desaturation at four (two ...
 37-579 4.13e-33

phytoene desaturase; Phytoene is converted to lycopene by desaturation at four (two symmetrical pairs of) sites. This is achieved by two enzymes (crtP and crtQ) in cyanobacteria (Gloeobacter being an exception) and plants, but by a single enzyme in most other bacteria and in fungi. This single enzyme is called the bacterial-type phytoene desaturase, or CrtI. Most members of this family, part of the larger pfam01593, which also contains amino oxidases, are CrtI itself; it is likely that all members act on either phytoene or on related compounds such as dehydrosqualene, for carotenoid biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 274273 [Multi-domain]  Cd Length: 495  Bit Score: 132.79  E-value: 4.13e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598   37 AVVIGAGHNGLVAAAYLQRLGVNTAVFERRHVIGGAAVTEEIiPGFKFSrasyllslLRPQICTDLELKKHGLKLhlrdp 116
Cdd:TIGR02734   1 AVVIGAGFGGLALAIRLAAAGIPVTVVEQRDKPGGRAGVLED-DGFRFD--------TGPTVITMPEALEELFAL----- 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598  117 ySFTPMLEEGTLNRL-P---------RSLLLGTDMAANQKEISQFSRKDAQAFPRYEEFMKRLV-LAIDPLLdaapvdTT 185
Cdd:TIGR02734  67 -AGRDLADYVELVPLdPfyrlcwedgSQLDVDNDQEELEAQIARFNPGDVAGYRRFLDYAERVYrEGYRKLG------YV 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598  186 AFqhgsllqrlralSTLKPLLKAGR-TLGAQLpqyyevLTAPISKVLDQRFESEPLKATLATDAV-IGamTSPHTPGSGY 263
Cdd:TIGR02734 140 PF------------LSPRDLLRADApQLLALL------AWRSLYSKVARFFSDERLRQAFSFHALfLG--GNPFRTPSIY 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598  264 VLLHHvmgsLEGTQGAWsYVQGGMGALSDAIASSAATRGASIFTEKTVAKVQVnSEGRAQGVTLQDGEEVRSRVVLSCAS 343
Cdd:TIGR02734 200 ALISA----LEREWGVW-FPRGGTGALVAAMAKLAEDLGGELRLNAEVIRIET-EGGRATAVHLADGERLDADAVVSNAD 273

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598  344 PQVTFLELTPQE--------------WLPGAFVKRISQLDTQspvtkinvavdrlpnfqaapnapGDQPQ-GHHqcSIHL 408
Cdd:TIGR02734 274 LHHTYRRLLPNHprrrypaarlsrkrPSPSLFVLYFGLLGVD-----------------------GHWPQlAHH--TLCF 328

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598  409 NCEDTLLLHQAFedaKGGLPSQKPMIELCIPSSLDPTLAPPGCHvvSLFTQY-TPYTLAGGKVWnEQEKNTYADKVFDCI 487
Cdd:TIGR02734 329 GPRYKELFDEIF---RKGRLAEDPSLYLHRPTVTDPSLAPPGCE--SLYVLApVPHLGTADVDW-SVEGPRYRDRILAYL 402

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598  488 EAYA-PGFKRSVLARDILTPPDLERIFRLPGGNIFHGAMSLDQLYFARPvpqHSDYRcPVQGLYLCGSGAHPGGGVMG-- 564
Cdd:TIGR02734 403 EERAiPGLRDRIVVERTFTPADFRDRYNAWLGSAFSLEHTLTQSAWFRP---HNRDR-KIDNLYLVGAGTHPGAGVPGvl 478

                         570
                  ....*....|....*
gi 125858598  565 AAGRNAAHVVFRDLK 579
Cdd:TIGR02734 479 GSAKATAKLMLGDLA 493
Amino_oxidase pfam01593
Flavin containing amine oxidoreductase; This family consists of various amine oxidases, ...
 46-571 1.73e-15

Flavin containing amine oxidoreductase; This family consists of various amine oxidases, including maze polyamine oxidase (PAO)and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.


Pssm-ID: 396255 [Multi-domain]  Cd Length: 446  Bit Score: 79.07  E-value: 1.73e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598   46 GLVAAAYLQRLGVNTAVFERRHVIGGAAVTEEIiPGFKFSR-ASyllSLLRPQICTDLELKKHGLKLHLRDPYSFTP--- 121
Cdd:pfam01593   3 GLAAARELLRAGHDVTVLEARDRVGGRIRTVRD-DGFLIELgAM---WFHGAQPPLLALLKELGLEDRLVLPDPAPFytv 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598  122 MLEEGTLNR---LPRSLLLGTDMAanqkeisqfsrkdaqaFPRYEEFMKRLVLAIDPLLdAAPVDTTAFQHGSLLQRLRA 198
Cdd:pfam01593  79 LFAGGRRYPgdfRRVPAGWEGLLE----------------FGRLLSIPEKLRLGLAALA-SDALDEFDLDDFSLAESLLF 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598  199 LStlkpllkaGRTLGAQlpqyyevltapisKVLDQRFESEPLKATLATDAVIGAMTSPHTPGSGYVLLHHVMGSLEGTqg 278
Cdd:pfam01593 142 LG--------RRGPGDV-------------EVWDRLIDPELFAALPFASGAFAGDPSELSAGLALPLLWALLGEGGSL-- 198

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598  279 awSYVQGGMGALSDAIASSAatRGASIFTEKTVAKVQVNSEGraQGVTLQDGEEVRSRVVLsCASPQVTFLELTPQEWLP 358
Cdd:pfam01593 199 --LLPRGGLGALPDALAAQL--LGGDVRLNTRVRSIDREGDG--VTVTLTDGEVIEADAVI-VTVPLGVLKRILFTPPLP 271

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598  359 GAFVKRISQLDTQsPVTKINVAVDRlpnfqaapnaPGDQPQGHHqcsiHLNCEDTLLLHQAFEdakgglpsqkpmielci 438
Cdd:pfam01593 272 PEKARAIRNLGYG-PVNKVHLEFDR----------KFWPDLGLL----GLLSELLTGLGTAFS----------------- 319

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598  439 pSSLDPTLAPPGcHVVSLFTqytpYTLAGGKVWNEQE--KNTYADKVFDCIeayapgfkRSVLARDILTPPDLERiFRLP 516
Cdd:pfam01593 320 -WLTFPNRAPPG-KGLLLLV----YVGPGDRARELEGlsDEELLQAVLRDL--------RKLFGEEAPEPLRVLV-SDWH 384

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 125858598  517 GGNIFHGAMSLDQLYfarpvPQHSDYR----CPVQGLYLCGSGAHPG--GGVMGA--AGRNAA 571
Cdd:pfam01593 385 TDPWPRGSYSLPQYG-----PGHDDYRplarTPDPGLFFAGEHTSTGypGTVEGAieSGRRAA 442
PRK11749 PRK11749
dihydropyrimidine dehydrogenase subunit A; Provisional
 39-83 1.87e-06

dihydropyrimidine dehydrogenase subunit A; Provisional


Pssm-ID: 236967 [Multi-domain]  Cd Length: 457  Bit Score: 50.56  E-value: 1.87e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 125858598  39 VIGAGHNGLVAAAYLQRLGVNTAVFERRHVIGGaaVTEEIIPGFK 83
Cdd:PRK11749 145 VIGAGPAGLTAAHRLARKGYDVTIFEARDKAGG--LLRYGIPEFR 187
PTZ00139 PTZ00139
Succinate dehydrogenase [ubiquinone] flavoprotein subunit; Provisional
 5-61 6.49e-03

Succinate dehydrogenase [ubiquinone] flavoprotein subunit; Provisional


Pssm-ID: 240286 [Multi-domain]  Cd Length: 617  Bit Score: 39.34  E-value: 6.49e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 125858598   5 GRGLIRALHSSPCPTwKRAQSGANGRLKPEYDAVVIGAGHNGLVAAAYLQRLGVNTA 61
Cdd:PTZ00139   1 RFAVPAFNRLTRTFF-SGHLSSAYPVIDHTYDAVVVGAGGAGLRAALGLVELGYKTA 56
 
Name Accession Description Interval E-value
COG1233 COG1233
Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and ...
 35-579 9.28e-127

Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440846 [Multi-domain]  Cd Length: 491  Bit Score: 381.12  E-value: 9.28e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598  35 YDAVVIGAGHNGLVAAAYLQRLGVNTAVFERRHVIGGAAVTEEIiPGFKFSRASYLLSLLRP--QICTDLELKKHgLKLH 112
Cdd:COG1233    4 YDVVVIGAGIGGLAAAALLARAGYRVTVLEKNDTPGGRARTFER-PGFRFDVGPSVLTMPGVleRLFRELGLEDY-LELV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598 113 LRDPySFTPMLEEGtlnrlpRSLLLGTDMAANQKEISQFSRKDAQAFPRYEEFMKRLVLAIDPLLDAAPvdttafqhgsl 192
Cdd:COG1233   82 PLDP-AYRVPFPDG------RALDLPRDLERTAAELERLFPGDAEAYRRFLAELRRLYDALLEDLLYRP----------- 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598 193 lqrlraLSTLKPLLKAgrtlgAQLPQYYEVLTAPISKVLDQRFESEPLKATLATdavIGAMTSPHTPGSGYVLlhHVMGS 272
Cdd:COG1233  144 ------LLSLRDLLRP-----LALARLLRLLLRSLRDLLRRYFKDPRLRALLAG---QALYLGLSPDRTPALY--ALIAY 207

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598 273 LEGTQGAWsYVQGGMGALSDAIASSAATRGASIFTEKTVAKVQVnSEGRAQGVTLQDGEEVRSRVVLSCASPQVTFLELT 352
Cdd:COG1233  208 LEYAGGVW-YPKGGMGALADALARLAEELGGEIRTGAEVERILV-EGGRATGVRLADGEEIRADAVVSNADPAHTYLRLL 285

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598 353 PQEWLPGAFVKRISQLDTQSPVTKINVAVDR-LPNFqaapnapgdqpqGHHQcsIHLNcEDtllLHQAFEDAKGGLPSQK 431
Cdd:COG1233  286 GEEALPARYRRRLERFRYSPSAFKLYLGLDGpLPGL------------AHHT--IHLS-ED---YEAAFDDIFRGRLPED 347

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598 432 PMIELCIPSSLDPTLAPPGCHVVSLFTQyTPYTLagGKVWnEQEKNTYADKVFDCIEAYAPGFKRSVLARDILTPPDLER 511
Cdd:COG1233  348 PSLYVSIPSLTDPSLAPEGKHTLWVLVP-VPYGL--EDAW-DELKEEYAERILARLERYAPGLRDRIVAREVLTPLDFER 423

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598 512 IFRLPGGNIFHGAMSLDQLYFARPvpqhSDYRCPVQGLYLCGSGAHPGGGVMGAA--GRNAAHVVFRDLK 579
Cdd:COG1233  424 YLNLVGGAIYGGAHTLDQSAFFRP----SNYRTPIPGLYLVGASTHPGGGVPGVLisGRLAARRILKDLK 489
crtI_fam TIGR02734
phytoene desaturase; Phytoene is converted to lycopene by desaturation at four (two ...
 37-579 4.13e-33

phytoene desaturase; Phytoene is converted to lycopene by desaturation at four (two symmetrical pairs of) sites. This is achieved by two enzymes (crtP and crtQ) in cyanobacteria (Gloeobacter being an exception) and plants, but by a single enzyme in most other bacteria and in fungi. This single enzyme is called the bacterial-type phytoene desaturase, or CrtI. Most members of this family, part of the larger pfam01593, which also contains amino oxidases, are CrtI itself; it is likely that all members act on either phytoene or on related compounds such as dehydrosqualene, for carotenoid biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 274273 [Multi-domain]  Cd Length: 495  Bit Score: 132.79  E-value: 4.13e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598   37 AVVIGAGHNGLVAAAYLQRLGVNTAVFERRHVIGGAAVTEEIiPGFKFSrasyllslLRPQICTDLELKKHGLKLhlrdp 116
Cdd:TIGR02734   1 AVVIGAGFGGLALAIRLAAAGIPVTVVEQRDKPGGRAGVLED-DGFRFD--------TGPTVITMPEALEELFAL----- 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598  117 ySFTPMLEEGTLNRL-P---------RSLLLGTDMAANQKEISQFSRKDAQAFPRYEEFMKRLV-LAIDPLLdaapvdTT 185
Cdd:TIGR02734  67 -AGRDLADYVELVPLdPfyrlcwedgSQLDVDNDQEELEAQIARFNPGDVAGYRRFLDYAERVYrEGYRKLG------YV 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598  186 AFqhgsllqrlralSTLKPLLKAGR-TLGAQLpqyyevLTAPISKVLDQRFESEPLKATLATDAV-IGamTSPHTPGSGY 263
Cdd:TIGR02734 140 PF------------LSPRDLLRADApQLLALL------AWRSLYSKVARFFSDERLRQAFSFHALfLG--GNPFRTPSIY 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598  264 VLLHHvmgsLEGTQGAWsYVQGGMGALSDAIASSAATRGASIFTEKTVAKVQVnSEGRAQGVTLQDGEEVRSRVVLSCAS 343
Cdd:TIGR02734 200 ALISA----LEREWGVW-FPRGGTGALVAAMAKLAEDLGGELRLNAEVIRIET-EGGRATAVHLADGERLDADAVVSNAD 273

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598  344 PQVTFLELTPQE--------------WLPGAFVKRISQLDTQspvtkinvavdrlpnfqaapnapGDQPQ-GHHqcSIHL 408
Cdd:TIGR02734 274 LHHTYRRLLPNHprrrypaarlsrkrPSPSLFVLYFGLLGVD-----------------------GHWPQlAHH--TLCF 328

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598  409 NCEDTLLLHQAFedaKGGLPSQKPMIELCIPSSLDPTLAPPGCHvvSLFTQY-TPYTLAGGKVWnEQEKNTYADKVFDCI 487
Cdd:TIGR02734 329 GPRYKELFDEIF---RKGRLAEDPSLYLHRPTVTDPSLAPPGCE--SLYVLApVPHLGTADVDW-SVEGPRYRDRILAYL 402

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598  488 EAYA-PGFKRSVLARDILTPPDLERIFRLPGGNIFHGAMSLDQLYFARPvpqHSDYRcPVQGLYLCGSGAHPGGGVMG-- 564
Cdd:TIGR02734 403 EERAiPGLRDRIVVERTFTPADFRDRYNAWLGSAFSLEHTLTQSAWFRP---HNRDR-KIDNLYLVGAGTHPGAGVPGvl 478

                         570
                  ....*....|....*
gi 125858598  565 AAGRNAAHVVFRDLK 579
Cdd:TIGR02734 479 GSAKATAKLMLGDLA 493
Amino_oxidase pfam01593
Flavin containing amine oxidoreductase; This family consists of various amine oxidases, ...
 46-571 1.73e-15

Flavin containing amine oxidoreductase; This family consists of various amine oxidases, including maze polyamine oxidase (PAO)and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.


Pssm-ID: 396255 [Multi-domain]  Cd Length: 446  Bit Score: 79.07  E-value: 1.73e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598   46 GLVAAAYLQRLGVNTAVFERRHVIGGAAVTEEIiPGFKFSR-ASyllSLLRPQICTDLELKKHGLKLHLRDPYSFTP--- 121
Cdd:pfam01593   3 GLAAARELLRAGHDVTVLEARDRVGGRIRTVRD-DGFLIELgAM---WFHGAQPPLLALLKELGLEDRLVLPDPAPFytv 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598  122 MLEEGTLNR---LPRSLLLGTDMAanqkeisqfsrkdaqaFPRYEEFMKRLVLAIDPLLdAAPVDTTAFQHGSLLQRLRA 198
Cdd:pfam01593  79 LFAGGRRYPgdfRRVPAGWEGLLE----------------FGRLLSIPEKLRLGLAALA-SDALDEFDLDDFSLAESLLF 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598  199 LStlkpllkaGRTLGAQlpqyyevltapisKVLDQRFESEPLKATLATDAVIGAMTSPHTPGSGYVLLHHVMGSLEGTqg 278
Cdd:pfam01593 142 LG--------RRGPGDV-------------EVWDRLIDPELFAALPFASGAFAGDPSELSAGLALPLLWALLGEGGSL-- 198

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598  279 awSYVQGGMGALSDAIASSAatRGASIFTEKTVAKVQVNSEGraQGVTLQDGEEVRSRVVLsCASPQVTFLELTPQEWLP 358
Cdd:pfam01593 199 --LLPRGGLGALPDALAAQL--LGGDVRLNTRVRSIDREGDG--VTVTLTDGEVIEADAVI-VTVPLGVLKRILFTPPLP 271

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598  359 GAFVKRISQLDTQsPVTKINVAVDRlpnfqaapnaPGDQPQGHHqcsiHLNCEDTLLLHQAFEdakgglpsqkpmielci 438
Cdd:pfam01593 272 PEKARAIRNLGYG-PVNKVHLEFDR----------KFWPDLGLL----GLLSELLTGLGTAFS----------------- 319

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598  439 pSSLDPTLAPPGcHVVSLFTqytpYTLAGGKVWNEQE--KNTYADKVFDCIeayapgfkRSVLARDILTPPDLERiFRLP 516
Cdd:pfam01593 320 -WLTFPNRAPPG-KGLLLLV----YVGPGDRARELEGlsDEELLQAVLRDL--------RKLFGEEAPEPLRVLV-SDWH 384

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 125858598  517 GGNIFHGAMSLDQLYfarpvPQHSDYR----CPVQGLYLCGSGAHPG--GGVMGA--AGRNAA 571
Cdd:pfam01593 385 TDPWPRGSYSLPQYG-----PGHDDYRplarTPDPGLFFAGEHTSTGypGTVEGAieSGRRAA 442
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
39-98 4.82e-10

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 55.62  E-value: 4.82e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 125858598   39 VIGAGHNGLVAAAYLQRLGVNTAVFERRHVIGGAAVTEEiIPGFKFSR-ASYLLSLLRPQI 98
Cdd:pfam13450   1 IVGAGLAGLVAAALLAKRGFRVLVLEKRDRLGGNAYSYR-VPGYVFDYgAHIFHGSDEPNV 60
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 35-383 2.06e-09

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 59.85  E-value: 2.06e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598  35 YDAVVIGAGHNGLVAAAYLQRLGVNTAVFERRHVIGGAAVTEEiIPGFKFSRASyllsllrpqictdlelkkHGlkLHLR 114
Cdd:COG1232    2 KRVAVIGGGIAGLTAAYRLAKAGHEVTVLEASDRVGGLIRTVE-VDGFRIDRGP------------------HS--FLTR 60

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598 115 DPYsftpmleegtLNRLPRSLLLGTDMAANQKEISQ-FSRKDAQAFPryeefmkrlvlaidplldAAPVDTTAFQHGSLL 193
Cdd:COG1232   61 DPE----------VLELLRELGLGDELVWPNTRKSYiYYGGKLHPLP------------------QGPLALLRSPLLSLA 112

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598 194 QRLRAL-STLKPLLKAG----------RTLGAQLpqyYEVLTAP-ISKV-------LDQRFESEPLKAT-LATDAVIGAM 253
Cdd:COG1232  113 GKLRALlELLAPRRPPGedeslaefvrRRFGREV---YERLVEPlLEGVyagdpdeLSADWAFPRLKRLeLEHGSLIKGA 189

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598 254 TSPHTPGSGyvllHHVMGSLEgtqgawsyvqGGMGALSDAIAssAATRGASIFTEKTVakVQVNSEGRAQGVTLQDGEEV 333
Cdd:COG1232  190 LALRKGAKA----GEVFGYLR----------GGLGTLVEALA--EALEAGEIRLGTRV--TAIEREGGGWRVTTSDGETI 251

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 125858598 334 RSRVVLSCASPQVTfLELTPQewLPGAFVKRISQLDTQSPVTkINVAVDR 383
Cdd:COG1232  252 EADAVVSATPAPAL-ARLLAP--LPPEVAAALAGIPYASVAV-VALGFDR 297
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 33-72 2.24e-08

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 56.41  E-value: 2.24e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 125858598  33 PEYDAVVIGAGHNGLVAAAYLQRLGVNTAVFERRHVIGGA 72
Cdd:COG2072    5 EHVDVVVIGAGQAGLAAAYHLRRAGIDFVVLEKADDVGGT 44
GltD COG0493
NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport ...
 27-86 8.75e-07

NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]; NADPH-dependent glutamate synthase beta chain or related oxidoreductase is part of the Pathway/BioSystem: Glutamine biosynthesis


Pssm-ID: 440259 [Multi-domain]  Cd Length: 434  Bit Score: 51.67  E-value: 8.75e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 125858598  27 ANGRLKPEYDAV-------VIGAGHNGLVAAAYLQRLGVNTAVFERRHVIGGaaVTEEIIPGFKFSR 86
Cdd:COG0493  107 EEGWVKPPPPAPrtgkkvaVVGSGPAGLAAAYQLARAGHEVTVFEALDKPGG--LLRYGIPEFRLPK 171
PRK11749 PRK11749
dihydropyrimidine dehydrogenase subunit A; Provisional
 39-83 1.87e-06

dihydropyrimidine dehydrogenase subunit A; Provisional


Pssm-ID: 236967 [Multi-domain]  Cd Length: 457  Bit Score: 50.56  E-value: 1.87e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 125858598  39 VIGAGHNGLVAAAYLQRLGVNTAVFERRHVIGGaaVTEEIIPGFK 83
Cdd:PRK11749 145 VIGAGPAGLTAAHRLARKGYDVTIFEARDKAGG--LLRYGIPEFR 187
TrxB COG0492
Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];
35-82 2.31e-06

Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440258 [Multi-domain]  Cd Length: 305  Bit Score: 49.73  E-value: 2.31e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 125858598  35 YDAVVIGAGHNGLVAAAYLQRLGVNTAVFERRHViGG-AAVTEEI--IPGF 82
Cdd:COG0492    1 YDVVIIGAGPAGLTAAIYAARAGLKTLVIEGGEP-GGqLATTKEIenYPGF 50
PRK06370 PRK06370
FAD-containing oxidoreductase;
33-74 3.92e-06

FAD-containing oxidoreductase;


Pssm-ID: 235787 [Multi-domain]  Cd Length: 463  Bit Score: 49.43  E-value: 3.92e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 125858598  33 PEYDAVVIGAGHNGLVAAAYLQRLGVNTAVFERRHViGGAAV 74
Cdd:PRK06370   4 QRYDAIVIGAGQAGPPLAARAAGLGMKVALIERGLL-GGTCV 44
PRK07233 PRK07233
hypothetical protein; Provisional
 38-580 7.29e-06

hypothetical protein; Provisional


Pssm-ID: 235977 [Multi-domain]  Cd Length: 434  Bit Score: 48.73  E-value: 7.29e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598  38 VVIGAGHNGLVAAAYLQRLGVNTAVFERRHVIGG-AAVTEeiIPGFK--------FSRASYLLSLLRpqictdlELkkhG 108
Cdd:PRK07233   3 AIVGGGIAGLAAAYRLAKRGHEVTVFEADDQLGGlAASFE--FGGLPierfyhhiFKSDEALLELLD-------EL---G 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598 109 L--KLHLRDPYsfTPMLEEGTLNRLprslllGTdmaanqkeisqfsrkdaqafpryeefmkrlvlaidplldaaPVDTTA 186
Cdd:PRK07233  71 LedKLRWRETK--TGYYVDGKLYPL------GT-----------------------------------------PLELLR 101

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598 187 FQHGSLLQRLR-ALSTL--------KPLLKAG------RTLGaqlPQYYEVLTAPiskVLDQRFESeplkatlATDAV-- 249
Cdd:PRK07233 102 FPHLSLIDKFRlGLLTLlarrikdwRALDKVPaeewlrRWSG---EGVYEVFWEP---LLESKFGD-------YADDVsa 168

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598 250 ------IGAMTSphtpgSGYVLLHHVMGslegtqgawsYVQGGMGALSDAIASSAATRGASIFTEKTVAKVQVNsEGRAQ 323
Cdd:PRK07233 169 awlwsrIKRRGN-----RRYSLFGEKLG----------YLEGGFATLIDALAEAIEARGGEIRLGTPVTSVVID-GGGVT 232

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598 324 GVTLQDGEEVRSRVVlSCASPQVtFLELTPQewLPGAFVKRISQLDTQSPVTKInVAVDR--LPNFQ---AAPNAPgdqp 398
Cdd:PRK07233 233 GVEVDGEEEDFDAVI-STAPPPI-LARLVPD--LPADVLARLRRIDYQGVVCMV-LKLRRplTDYYWlniNDPGAP---- 303

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598 399 qghhqcsihlncedtlllhqaFedakGGLpsqkpmIELcipSSLDPTLAPPGCHVVslftqYTPYTLAGGK-VWNEQEKN 477
Cdd:PRK07233 304 ---------------------F----GGV------IEH---TNLVPPERYGGEHLV-----YLPKYLPGDHpLWQMSDEE 344

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598 478 tYADKVFDCIEAYAPGFKRSvlarDILtppDLeRIFRLPggnifhgamsldqlyFARPV--PQHSD----YRCPVQGLYL 551
Cdd:PRK07233 345 -LLDRFLSYLRKMFPDFDRD----DVR---AV-RISRAP---------------YAQPIyePGYLDkippYDTPIEGLYL 400

                        570       580       590
                 ....*....|....*....|....*....|....*
gi 125858598 552 CG-SGAHPG-----GGVmgAAGRNAAHVVFRDLKN 580
Cdd:PRK07233 401 AGmSQIYPEdrsinGSV--RAGRRVAREILEDRRN 433
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
30-383 1.38e-05

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 47.61  E-value: 1.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598  30 RLKPEYDAVVIGAGHNGLVAAAYLQRLGVNTAVFERRHVIGGAAVTEEI-------------IPGfkfsRASYLLSLLRp 96
Cdd:COG1231    3 RRARGKDVVIVGAGLAGLAAARELRKAGLDVTVLEARDRVGGRVWTLRFgddglyaelgamrIPP----SHTNLLALAR- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598  97 qictdlelkKHGLKLhlrdpysftpmleegtlnrlprslllgtdmaanqkeisqfsrkdaqaFPRYEEFMKRLVlaidpL 176
Cdd:COG1231   78 ---------ELGLPL-----------------------------------------------EPFPNENGNALL-----Y 96

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598 177 LDAAPVDTTAFQHgsllqRLRALSTLkpLLKAGRTLGAQLPQYYEVLTA----PISKVLDQRFESEPLKATLATdAVIGA 252
Cdd:COG1231   97 LGGKRVRAGEIAA-----DLRGVAEL--LAKLLRALAAALDPWAHPAAEldreSLAEWLRRNGASPSARRLLGL-LGAGE 168

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598 253 MTSPHTPGSgyvlLHHV--MGSLEGTQGAWSYVQGGMGALSDAIASSAatrGASIFTEKTVAKVqvnsEGRAQGVTLQ-- 328
Cdd:COG1231  169 YGADPDELS----LLDLlrYAASAGGGAQQFRIVGGMDQLPRALAAEL---GDRIRLGAPVTRI----RQDGDGVTVTtd 237

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 125858598 329 DGEEVRSRVVLSCASPQV-TFLELTPQewLPGAFVKRISQLdTQSPVTKINVAVDR 383
Cdd:COG1231  238 DGGTVRADAVIVTVPPSVlRRIEFDPP--LPAAKRAAIQRL-PYGAAIKVFLQFDR 290
gltD PRK12810
glutamate synthase subunit beta; Reviewed
 27-83 4.33e-05

glutamate synthase subunit beta; Reviewed


Pssm-ID: 237213 [Multi-domain]  Cd Length: 471  Bit Score: 46.31  E-value: 4.33e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 125858598  27 ANGRLKPEYDAV-------VIGAGHNGLVAAAYLQRLGVNTAVFERRHVIGGaaVTEEIIPGFK 83
Cdd:PRK12810 129 EEGWVKPDPPVKrtgkkvaVVGSGPAGLAAADQLARAGHKVTVFERADRIGG--LLRYGIPDFK 190
PLN02576 PLN02576
protoporphyrinogen oxidase
 26-71 5.74e-05

protoporphyrinogen oxidase


Pssm-ID: 215314 [Multi-domain]  Cd Length: 496  Bit Score: 45.77  E-value: 5.74e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 125858598  26 GANGRLKPEYDAVVIGAGHNGLVAAAYLQ-RLGVNTAVFERRHVIGG 71
Cdd:PLN02576   4 AEGSAAASSKDVAVVGAGVSGLAAAYALAsKHGVNVLVTEARDRVGG 50
Lpd COG1249
Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex ...
 34-80 7.54e-05

Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase [Energy production and conversion]; Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase is part of the Pathway/BioSystem: Glycine cleavagePyruvate oxidation


Pssm-ID: 440861 [Multi-domain]  Cd Length: 456  Bit Score: 45.46  E-value: 7.54e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 125858598  34 EYDAVVIGAGHNGLVAAAYLQRLGVNTAVFERRHViGGAAVTEEIIP 80
Cdd:COG1249    3 DYDLVVIGAGPGGYVAAIRAAQLGLKVALVEKGRL-GGTCLNVGCIP 48
SdhA COG1053
Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and ...
 34-74 7.70e-05

Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440673 [Multi-domain]  Cd Length: 443  Bit Score: 45.21  E-value: 7.70e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 125858598  34 EYDAVVIGAGHNGLVAAAYLQRLGVNTAVFERRHVIGGAAV 74
Cdd:COG1053    3 EYDVVVVGSGGAGLRAALEAAEAGLKVLVLEKVPPRGGHTA 43
PRK12775 PRK12775
putative trifunctional 2-polyprenylphenol hydroxylase/glutamate synthase subunit beta/ferritin ...
 39-86 8.90e-05

putative trifunctional 2-polyprenylphenol hydroxylase/glutamate synthase subunit beta/ferritin domain-containing protein; Provisional


Pssm-ID: 183738 [Multi-domain]  Cd Length: 1006  Bit Score: 45.70  E-value: 8.90e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 125858598   39 VIGAGHNGLVAAAYLQRLGVNTAVFERRHVIGGaaVTEEIIPGFKFSR 86
Cdd:PRK12775  435 ICGSGPAGLAAAADLVKYGVDVTVYEALHVVGG--VLQYGIPSFRLPR 480
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 36-73 1.16e-04

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 44.70  E-value: 1.16e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 125858598   36 DAVVIGAGHNGLVAAAYLQRLGVNTAVFERRHVIGGAA 73
Cdd:pfam01266   1 DVVVIGGGIVGLSTAYELARRGLSVTLLERGDDPGSGA 38
PRK05249 PRK05249
Si-specific NAD(P)(+) transhydrogenase;
34-74 1.65e-04

Si-specific NAD(P)(+) transhydrogenase;


Pssm-ID: 235373 [Multi-domain]  Cd Length: 461  Bit Score: 44.38  E-value: 1.65e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 125858598  34 EYDAVVIGAGHNGLVAAAYLQRLGVNTAVFERRHVIGGAAV 74
Cdd:PRK05249   5 DYDLVVIGSGPAGEGAAMQAAKLGKRVAVIERYRNVGGGCT 45
UbiH COG0654
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme ...
 33-66 1.74e-04

2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440419 [Multi-domain]  Cd Length: 326  Bit Score: 43.77  E-value: 1.74e-04
                         10        20        30
                 ....*....|....*....|....*....|....
gi 125858598  33 PEYDAVVIGAGHNGLVAAAYLQRLGVNTAVFERR 66
Cdd:COG0654    2 MRTDVLIVGGGPAGLALALALARAGIRVTVVERA 35
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
34-72 2.20e-04

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 43.74  E-value: 2.20e-04
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 125858598  34 EYDAVVIGAGHNGLVAAAYLQRLGVNTAVFERRHVIGGA 72
Cdd:COG0665    2 TADVVVIGGGIAGLSTAYHLARRGLDVTVLERGRPGSGA 40
Thi4 pfam01946
Thi4 family; This family includes Swiss:P32318 a putative thiamine biosynthetic enzyme.
 34-73 3.99e-04

Thi4 family; This family includes Swiss:P32318 a putative thiamine biosynthetic enzyme.


Pssm-ID: 460393  Cd Length: 232  Bit Score: 42.07  E-value: 3.99e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 125858598   34 EYDAVVIGAGHNGLVAAAYL-QRLGVNTAVFERRHVIGGAA 73
Cdd:pfam01946  17 ESDVVIVGAGSSGLTAAYYLaKNRGLKVAIIERSVSPGGGA 57
PLN02976 PLN02976
amine oxidase
 38-76 4.32e-04

amine oxidase


Pssm-ID: 215527 [Multi-domain]  Cd Length: 1713  Bit Score: 43.32  E-value: 4.32e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 125858598   38 VVIGAGHNGLVAAAYLQRLGVNTAVFERRHVIGGAAVTE 76
Cdd:PLN02976  697 IVVGAGPAGLTAARHLQRQGFSVTVLEARSRIGGRVYTD 735
PRK10157 PRK10157
putative oxidoreductase FixC; Provisional
 35-82 8.45e-04

putative oxidoreductase FixC; Provisional


Pssm-ID: 182273 [Multi-domain]  Cd Length: 428  Bit Score: 42.21  E-value: 8.45e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 125858598  35 YDAVVIGAGHNGLVAAAYLQRLGVNTAVFERRHVIGGAAVT---------EEIIPGF 82
Cdd:PRK10157   6 FDAIIVGAGLAGSVAALVLAREGAQVLVIERGNSAGAKNVTggrlyahslEHIIPGF 62
PRK10015 PRK10015
oxidoreductase; Provisional
 34-82 1.23e-03

oxidoreductase; Provisional


Pssm-ID: 182194 [Multi-domain]  Cd Length: 429  Bit Score: 41.50  E-value: 1.23e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 125858598  34 EYDAVVIGAGHNGLVAAAYLQRLGVNTAVFER------RHVIGG---AAVTEEIIPGF 82
Cdd:PRK10015   5 KFDAIVVGAGVAGSVAALVMARAGLDVLVIERgdsagcKNMTGGrlyAHTLEAIIPGF 62
PRK07208 PRK07208
hypothetical protein; Provisional
 36-77 2.25e-03

hypothetical protein; Provisional


Pssm-ID: 235967 [Multi-domain]  Cd Length: 479  Bit Score: 40.64  E-value: 2.25e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 125858598  36 DAVVIGAGHNGLVAAAYLQRLGVNTAVFERRHVIGGAAVTEE 77
Cdd:PRK07208   6 SVVIIGAGPAGLTAAYELLKRGYPVTVLEADPVVGGISRTVT 47
GIDA pfam01134
Glucose inhibited division protein A;
36-63 2.29e-03

Glucose inhibited division protein A;


Pssm-ID: 250388 [Multi-domain]  Cd Length: 391  Bit Score: 40.61  E-value: 2.29e-03
                          10        20
                  ....*....|....*....|....*...
gi 125858598   36 DAVVIGAGHNGLVAAAYLQRLGVNTAVF 63
Cdd:pfam01134   1 DVIVIGGGHAGCEAALAAARMGAKVLLI 28
PRK06416 PRK06416
dihydrolipoamide dehydrogenase; Reviewed
 34-71 2.51e-03

dihydrolipoamide dehydrogenase; Reviewed


Pssm-ID: 235798 [Multi-domain]  Cd Length: 462  Bit Score: 40.51  E-value: 2.51e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 125858598  34 EYDAVVIGAGHNGLVAAAYLQRLGVNTAVFERRHvIGG 71
Cdd:PRK06416   4 EYDVIVIGAGPGGYVAAIRAAQLGLKVAIVEKEK-LGG 40
PRK06753 PRK06753
hypothetical protein; Provisional
 39-69 3.32e-03

hypothetical protein; Provisional


Pssm-ID: 168661 [Multi-domain]  Cd Length: 373  Bit Score: 40.06  E-value: 3.32e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 125858598  39 VIGAGHNGLVAAAYLQRLGVNTAVFERRHVI 69
Cdd:PRK06753   5 IIGAGIGGLTAAALLQEQGHEVKVFEKNESV 35
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 35-111 3.43e-03

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 39.61  E-value: 3.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125858598   35 YDAVVIGAGHNGLVAAAYLQRLGVNTAVFERR-----------HVIGGAAVTEEIIPGFKFSRASYLLSLLRPQICTDLE 103
Cdd:pfam07992   1 YDVVVIGGGPAGLAAALTLAQLGGKVTLIEDEgtcpyggcvlsKALLGAAEAPEIASLWADLYKRKEEVVKKLNNGIEVL 80


                  ....*...
gi 125858598  104 LKKHGLKL 111
Cdd:pfam07992  81 LGTEVVSI 88
PRK12844 PRK12844
3-ketosteroid-delta-1-dehydrogenase; Reviewed
 34-72 3.94e-03

3-ketosteroid-delta-1-dehydrogenase; Reviewed


Pssm-ID: 183787 [Multi-domain]  Cd Length: 557  Bit Score: 40.12  E-value: 3.94e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 125858598  34 EYDAVVIGAGHNGLVAAAYLQRLGVNTAVFERRHVIGGA 72
Cdd:PRK12844   6 TYDVVVVGSGGGGMCAALAAADSGLEPLIVEKQDKVGGS 44
PRK06481 PRK06481
flavocytochrome c;
31-71 4.82e-03

flavocytochrome c;


Pssm-ID: 180584 [Multi-domain]  Cd Length: 506  Bit Score: 39.82  E-value: 4.82e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 125858598  31 LKPEYDAVVIGAGHNGLVAAAYLQRLGVNTAVFERRHVIGG 71
Cdd:PRK06481  58 LKDKYDIVIVGAGGAGMSAAIEAKDAGMNPVILEKMPVAGG 98
Pyr_redox pfam00070
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 37-113 4.96e-03

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 425450 [Multi-domain]  Cd Length: 80  Bit Score: 36.03  E-value: 4.96e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 125858598   37 AVVIGAGHNGLVAAAYLQRLGVNTAVFERRhviggaavteeiipgfkfsraSYLLSLLRPQICTDL--ELKKHGLKLHL 113
Cdd:pfam00070   2 VVVVGGGYIGLELAGALARLGSKVTVVERR---------------------DRLLPGFDPEIAKILqeKLEKNGIEFLL 59
PRK06292 PRK06292
dihydrolipoamide dehydrogenase; Validated
 34-65 5.86e-03

dihydrolipoamide dehydrogenase; Validated


Pssm-ID: 235774 [Multi-domain]  Cd Length: 460  Bit Score: 39.39  E-value: 5.86e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 125858598  34 EYDAVVIGAGHNGLVAAAYLQRLGVNTAVFER 65
Cdd:PRK06292   3 KYDVIVIGAGPAGYVAARRAAKLGKKVALIEK 34
FAD_binding_2 pfam00890
FAD binding domain; This family includes members that bind FAD. This family includes the ...
 36-74 6.27e-03

FAD binding domain; This family includes members that bind FAD. This family includes the flavoprotein subunits from succinate and fumarate dehydrogenase, aspartate oxidase and the alpha subunit of adenylylsulphate reductase.


Pssm-ID: 395718 [Multi-domain]  Cd Length: 398  Bit Score: 39.19  E-value: 6.27e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 125858598   36 DAVVIGAGHNGLVAAAYLQRLGVNTAVFERRHVIGGAAV 74
Cdd:pfam00890   1 DVLVIGGGLAGLAAALAAAEAGLKVAVVEKGQPFGGATA 39
PTZ00139 PTZ00139
Succinate dehydrogenase [ubiquinone] flavoprotein subunit; Provisional
 5-61 6.49e-03

Succinate dehydrogenase [ubiquinone] flavoprotein subunit; Provisional


Pssm-ID: 240286 [Multi-domain]  Cd Length: 617  Bit Score: 39.34  E-value: 6.49e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 125858598   5 GRGLIRALHSSPCPTwKRAQSGANGRLKPEYDAVVIGAGHNGLVAAAYLQRLGVNTA 61
Cdd:PTZ00139   1 RFAVPAFNRLTRTFF-SGHLSSAYPVIDHTYDAVVVGAGGAGLRAALGLVELGYKTA 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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