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Conserved domains on  [gi|256773193|ref|NP_083860|]
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uncharacterized protein LOC76373 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 75-115 1.80e-12

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 61.33  E-value: 1.80e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 256773193   75 MAFSDVAIYFLRGEWRLLDDSQRRLYHQVMMEVFVLMSSLG 115
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
180-418 1.14e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.56  E-value: 1.14e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773193 180 CRISVPKRNRSDPSEKTLQSTDNTMDCHTLSglHRHHVTHSAVERPKSTKRGKATPsekrnCKCYDCGKSFNCKSLLIRH 259
Cdd:COG5048  236 SPKSLLSQSPSSLSSSDSSSSASESPRSSLP--TASSQSSSPNESDSSSEKGFSLP-----IKSKQCNISFSRSSPLTRH 308

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773193 260 RR--IHTGE--KPFKCSE--CEKSFIQKTDLNQHLKVHTGEKPFRCSECGKDFKHNRSLvghqrlhtgekpykcNQCGES 333
Cdd:COG5048  309 LRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLL---------------NNEPPQ 373

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773193 334 YMNRSSLICHYLVHTGEKPykcgECGKLFKEKSSLVYHTRVHTGERP--FECSQCRKCFKKNSHLVKHQKVHSRGRPFKC 411
Cdd:COG5048  374 SLQQYKDLKNDKKSETLSN----SCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC 449


                 ....*..
gi 256773193 412 NVCGRYF 418
Cdd:COG5048  450 SILKSFR 456
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 75-115 1.80e-12

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 61.33  E-value: 1.80e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 256773193   75 MAFSDVAIYFLRGEWRLLDDSQRRLYHQVMMEVFVLMSSLG 115
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 75-114 3.73e-11

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 57.56  E-value: 3.73e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 256773193  75 MAFSDVAIYFLRGEWRLLDDSQRRLYHQVMMEVFVLMSSL 114
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
KRAB smart00349
krueppel associated box;
75-126 3.93e-11

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 58.37  E-value: 3.93e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 256773193    75 MAFSDVAIYFLRGEWRLLDDSQRRLYHQVMMEVFVLMSSLGL-IPSGTDITQL 126
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFqVPKPDLISQL 53
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
180-418 1.14e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.56  E-value: 1.14e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773193 180 CRISVPKRNRSDPSEKTLQSTDNTMDCHTLSglHRHHVTHSAVERPKSTKRGKATPsekrnCKCYDCGKSFNCKSLLIRH 259
Cdd:COG5048  236 SPKSLLSQSPSSLSSSDSSSSASESPRSSLP--TASSQSSSPNESDSSSEKGFSLP-----IKSKQCNISFSRSSPLTRH 308

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773193 260 RR--IHTGE--KPFKCSE--CEKSFIQKTDLNQHLKVHTGEKPFRCSECGKDFKHNRSLvghqrlhtgekpykcNQCGES 333
Cdd:COG5048  309 LRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLL---------------NNEPPQ 373

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773193 334 YMNRSSLICHYLVHTGEKPykcgECGKLFKEKSSLVYHTRVHTGERP--FECSQCRKCFKKNSHLVKHQKVHSRGRPFKC 411
Cdd:COG5048  374 SLQQYKDLKNDKKSETLSN----SCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC 449


                 ....*..
gi 256773193 412 NVCGRYF 418
Cdd:COG5048  450 SILKSFR 456
zf-H2C2_2 pfam13465
Zinc-finger double domain;
283-308 1.42e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.42e-04
                          10        20
                  ....*....|....*....|....*.
gi 256773193  283 DLNQHLKVHTGEKPFRCSECGKDFKH 308
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 75-115 1.80e-12

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 61.33  E-value: 1.80e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 256773193   75 MAFSDVAIYFLRGEWRLLDDSQRRLYHQVMMEVFVLMSSLG 115
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 75-114 3.73e-11

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 57.56  E-value: 3.73e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 256773193  75 MAFSDVAIYFLRGEWRLLDDSQRRLYHQVMMEVFVLMSSL 114
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
KRAB smart00349
krueppel associated box;
75-126 3.93e-11

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 58.37  E-value: 3.93e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 256773193    75 MAFSDVAIYFLRGEWRLLDDSQRRLYHQVMMEVFVLMSSLGL-IPSGTDITQL 126
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFqVPKPDLISQL 53
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
180-418 1.14e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.56  E-value: 1.14e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773193 180 CRISVPKRNRSDPSEKTLQSTDNTMDCHTLSglHRHHVTHSAVERPKSTKRGKATPsekrnCKCYDCGKSFNCKSLLIRH 259
Cdd:COG5048  236 SPKSLLSQSPSSLSSSDSSSSASESPRSSLP--TASSQSSSPNESDSSSEKGFSLP-----IKSKQCNISFSRSSPLTRH 308

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773193 260 RR--IHTGE--KPFKCSE--CEKSFIQKTDLNQHLKVHTGEKPFRCSECGKDFKHNRSLvghqrlhtgekpykcNQCGES 333
Cdd:COG5048  309 LRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLL---------------NNEPPQ 373

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773193 334 YMNRSSLICHYLVHTGEKPykcgECGKLFKEKSSLVYHTRVHTGERP--FECSQCRKCFKKNSHLVKHQKVHSRGRPFKC 411
Cdd:COG5048  374 SLQQYKDLKNDKKSETLSN----SCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC 449


                 ....*..
gi 256773193 412 NVCGRYF 418
Cdd:COG5048  450 SILKSFR 456
zf-H2C2_2 pfam13465
Zinc-finger double domain;
283-308 1.42e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.42e-04
                          10        20
                  ....*....|....*....|....*.
gi 256773193  283 DLNQHLKVHTGEKPFRCSECGKDFKH 308
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
256-280 1.42e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.42e-04
                          10        20
                  ....*....|....*....|....*
gi 256773193  256 LIRHRRIHTGEKPFKCSECEKSFIQ 280
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 345-437 2.08e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.55  E-value: 2.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773193 345 LVHTGEKPYKCG--ECGKLFKEKSSLVYHtRVHtgerpfecSQCRKCFKKNSHLVKHQKVHSRGRPFKCNVCGRyftmRY 422
Cdd:COG5189  342 LKVKDGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDK----RY 408

                         90
                 ....*....|....*
gi 256773193 423 SLIKHQRFHTAAKHH 437
Cdd:COG5189  409 KNLNGLKYHRKHSHD 423
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 293-376 1.37e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 1.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773193 293 GEKPFRCS--ECGKDFKHNRSLVGHqRLHtgekpykcNQCGESYMNRSSLICHYLVHTGEKPYKCGECGKLFKEKSSLVY 370
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 256773193 371 HtRVHT 376
Cdd:COG5189  417 H-RKHS 421
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
235-399 1.80e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.83  E-value: 1.80e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773193 235 PSEKRNCKCYDCGKSFNCKSLLIRHRRIHTGEKPFKC--SECEKSFIQKTDLNQHLKVHtgekpfrcsecgkdfKHNRSL 312
Cdd:COG5048  318 SLKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQ---------------QYKDLK 382

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773193 313 VGHQRLHTGekpykcNQCGESYMNRSSLICHYLVHTGEKP--YKCGECGKLFKEKSSLVYHTRVHTGERPFECSQCRKcF 390
Cdd:COG5048  383 NDKKSETLS------NSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-F 455


                 ....*....
gi 256773193 391 KKNSHLVKH 399
Cdd:COG5048  456 RRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
367-392 3.51e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.51e-03
                          10        20
                  ....*....|....*....|....*.
gi 256773193  367 SLVYHTRVHTGERPFECSQCRKCFKK 392
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
232-311 6.18e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.91  E-value: 6.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256773193 232 KATPSEKRNCKCYDCGKSFNCKSLLIRHRRIHTGEKPFKCS--ECEKSFIQKTDLNQHLKVHTGEKPFRCSECGKDFKHN 309
Cdd:COG5048   25 KSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSK 104


                 ..
gi 256773193 310 RS 311
Cdd:COG5048  105 AS 106
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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