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Conserved domains on  [gi|58037493|ref|NP_084208|]
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protein spinster homolog 3 [Mus musculus]

Protein Classification

spinster family MFS transporter( domain architecture ID 13023647)

spinster family major facilitator superfamily (MFS) transporter may function as a sphingolipid transporter that plays a central role in endosome and/or lysosome storage

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085|GO:0006869
PubMed:  26758938|26098515
TCDB:  2.A.1.49

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 53-469 8.65e-163

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 467.48  E-value: 8.65e-163
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493  53 AVLCYINLLNYMNWFIIPGVLLDVQKYFHISDSHAGLLQTVFISCLLVSAPVFGYLGDRYNRKAILSFGILLWSGAGLSS 132
Cdd:cd17328   2 AVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 133 SFISYqySWLFFLSRGFVGTGAASYSTIAPTVLGDLFVKDQRTCALAVFYIFIPVGSGLGYVLGSTVAELTGNWRWALRL 212
Cdd:cd17328  82 SFAPN--FWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWRWAFRV 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 213 MPCLDAMALALLILLVPDVPRGAAEkqGEVAVRAPRSSWCEDVRYLGRNWSFVFSTLGVTAIAFVTGALGFWAPKFLFEA 292
Cdd:cd17328 160 TGVLGVLLAILLLLFVREPPRGAAE--GGVMAKSTATSFLADLKALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRA 237

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 293 RVVHGLQLpcfqeqchSQDSLIFGALTVATGIIGVMLGAEASRRYKKVNPRAEPLICASSLFATAPCLYLALILASRTLL 372
Cdd:cd17328 238 FGVGDLSS--------ADVGLIFGAITCIAGVLGVLLGGILADRLRRKTPRADPLVCAVGLLAAAPFLFLALVLALSNLL 309

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 373 ASYVFLALGELLLSCNWAVVADILLSVVVPRCRGTAEALQITVAHVLGDAGSPYLTGLISSVLqAERPDSYLQHFLSLQH 452
Cdd:cd17328 310 LAWVLLFLGEFLLSLNWAPVFAILLYVVIPTRRSTASAIQILLSHLLGDAGSPYLIGLISDLL-RQNKDSPLAEAASLQY 388

                       410
                ....*....|....*..
gi 58037493 453 SFLCCAFAIVLGGGFFL 469
Cdd:cd17328 389 ALLLCSFVLVLGGFFFL 405
 
Name Accession Description Interval E-value
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 53-469 8.65e-163

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 467.48  E-value: 8.65e-163
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493  53 AVLCYINLLNYMNWFIIPGVLLDVQKYFHISDSHAGLLQTVFISCLLVSAPVFGYLGDRYNRKAILSFGILLWSGAGLSS 132
Cdd:cd17328   2 AVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 133 SFISYqySWLFFLSRGFVGTGAASYSTIAPTVLGDLFVKDQRTCALAVFYIFIPVGSGLGYVLGSTVAELTGNWRWALRL 212
Cdd:cd17328  82 SFAPN--FWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWRWAFRV 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 213 MPCLDAMALALLILLVPDVPRGAAEkqGEVAVRAPRSSWCEDVRYLGRNWSFVFSTLGVTAIAFVTGALGFWAPKFLFEA 292
Cdd:cd17328 160 TGVLGVLLAILLLLFVREPPRGAAE--GGVMAKSTATSFLADLKALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRA 237

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 293 RVVHGLQLpcfqeqchSQDSLIFGALTVATGIIGVMLGAEASRRYKKVNPRAEPLICASSLFATAPCLYLALILASRTLL 372
Cdd:cd17328 238 FGVGDLSS--------ADVGLIFGAITCIAGVLGVLLGGILADRLRRKTPRADPLVCAVGLLAAAPFLFLALVLALSNLL 309

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 373 ASYVFLALGELLLSCNWAVVADILLSVVVPRCRGTAEALQITVAHVLGDAGSPYLTGLISSVLqAERPDSYLQHFLSLQH 452
Cdd:cd17328 310 LAWVLLFLGEFLLSLNWAPVFAILLYVVIPTRRSTASAIQILLSHLLGDAGSPYLIGLISDLL-RQNKDSPLAEAASLQY 388

                       410
                ....*....|....*..
gi 58037493 453 SFLCCAFAIVLGGGFFL 469
Cdd:cd17328 389 ALLLCSFVLVLGGFFFL 405
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
42-477 1.82e-28

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 116.12  E-value: 1.82e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493  42 SLPRWRAYLAAAVLCYINLLNYMNWFIIPGVLLDVQKYFHISDSHAGLLQTVFISCLLVSAPVFGYLGDRYNRKAILSFG 121
Cdd:COG2271   2 RAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 122 ILLWSGAGLSSSFIsyQYSWLFFLSRGFVGTGAASYSTIAPTVLGDLFVKDQRTCALAVFYIFIPVGSGLGYVLGSTVAE 201
Cdd:COG2271  82 LLLWGLATLLFGFA--TSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLA 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 202 LTGnWRWALRLMpcldamalallillvpdvprGAAekqgeVAVRAPrsswcedvrylgrnWSFVFSTLGVTAIAFVTGAL 281
Cdd:COG2271 160 AFG-WRAAFLIL--------------------GLP-----GLLLAL--------------LRFWLLALAYFLVYFALYGF 199

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 282 GFWAPKFLFEarvVHGLQLpcfqeqchsQDSLIFGALTVATGIIGVMLGAEASRRYKkvnpRAEPLICASSLFATAPCLY 361
Cdd:COG2271 200 LTWLPTYLVE---VRGLSL---------AQAGLLLSLPFLAGIVGSLLGGWLSDRLG----RRRKLVLAIGLLLAALALL 263

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 362 LALILASRTLLasYVFLALGELLLSCNWAVVADILLSVVVPRCRGTAEALqITVAHVLGDAGSPYLTGLISSvlqaerpd 441
Cdd:COG2271 264 LLALLPSPALA--IALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGL-VNTFGFLGGALGPLLVGYLLD-------- 332

                       410       420       430
                ....*....|....*....|....*....|....*.
gi 58037493 442 sylqhFLSLQHSFLCCAFAIVLGGGFFLLTALHLEK 477
Cdd:COG2271 333 -----ATGYQAAFLLLAALALLAALLALLLLRETRK 363
MFS_1 pfam07690
Major Facilitator Superfamily;
55-418 5.97e-22

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 97.10  E-value: 5.97e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493    55 LCYINLLNYMNWFIIPGVL-LDVQKYFHISDSHAGLLQTVFISCLLVSAPVFGYLGDRYNRKAILSFGILLWSGAGLSSS 133
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALpLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493   134 FISyqYSWLFFLSRGFVGTGAASYSTIAPTVLGDLFVKDQRTCALAVFYIFIPVGSGLGYVLGSTVAELTGnWRWALRLM 213
Cdd:pfam07690  81 FAS--SLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG-WRAAFLIL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493   214 PCLDAMALALLILLVPDVPRGAAEKQGEVAVRAPrsswcEDVRYLGRNWSFVFSTLGVTAiAFVTGALGFWAPKFLfear 293
Cdd:pfam07690 158 AILSLLAAVLLLLPRPPPESKRPKPAEEARLSLI-----VAWKALLRDPVLWLLLALLLF-GFAFFGLLTYLPLYQ---- 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493   294 VVHGLQLpcfqeqchsQDSLIFGALTVATGIIGVMLGAEASRRYKKVNPRAepLICASSLFATAPCLYLALILASRTLLA 373
Cdd:pfam07690 228 EVLGLSA---------LLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLL--LALLLLILAALGLLLLSLTLSSLWLLL 296

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 58037493   374 SYVFLALGellLSCNWAVVADILLSVVVPRCRGTAEALQITVAHV 418
Cdd:pfam07690 297 ALLLLGFG---FGLVFPALNALVSDLAPKEERGTASGLYNTAGSL 338
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 87-208 3.32e-08

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 55.79  E-value: 3.32e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493    87 AGLLQTVFISCLLVSAPVFGYLGDRYNRKAILSFGILLWSGAGLSSSFiSYQYSWLFFLsRGFVGTGAASYSTIAPTVLG 166
Cdd:TIGR00898 129 VDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAF-SPNYTVFLVF-RLLVGMGIGGIWVQAVVLNT 206

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 58037493   167 DLFVKDQRtcalAVFYIFIPVGSGLGYVLGSTVAELTGNWRW 208
Cdd:TIGR00898 207 EFLPKKQR----AIVGTLIQVFFSLGLVLLPLVAYFIPDWRW 244
PRK03893 PRK03893
putative sialic acid transporter; Provisional
 35-208 7.95e-04

putative sialic acid transporter; Provisional


Pssm-ID: 179668 [Multi-domain]  Cd Length: 496  Bit Score: 41.99  E-value: 7.95e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493   35 PSTPVPW----SLPRWRAYLAAaVLCYinLLNYMNWFIIPGVLLDVQKYFHISDSHAG-LLQTVFISCLLvSAPVFGYLG 109
Cdd:PRK03893   4 TTQNIPWyrhlNRAQWKAFSAA-WLGY--LLDGFDFVLITLVLTEVQGEFGLTTVQAAsLISAAFISRWF-GGLLLGAMG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493  110 DRYNRKAILSFGILLWSGAGLSSSFiSYQYsWLFFLSRGFVGTG-AASYSTIAPTVLgDLFVKDQRTCALAVFYIFIPVG 188
Cdd:PRK03893  80 DRYGRRLAMVISIVLFSVGTLACGF-APGY-WTLFIARLVIGMGmAGEYGSSATYVI-ESWPKHLRNKASGFLISGFSIG 156

                        170       180
                 ....*....|....*....|
gi 58037493  189 SGLGYVLGSTVAELTGnWRW 208
Cdd:PRK03893 157 AVVAAQVYSLVVPVWG-WRA 175
 
Name Accession Description Interval E-value
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 53-469 8.65e-163

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 467.48  E-value: 8.65e-163
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493  53 AVLCYINLLNYMNWFIIPGVLLDVQKYFHISDSHAGLLQTVFISCLLVSAPVFGYLGDRYNRKAILSFGILLWSGAGLSS 132
Cdd:cd17328   2 AVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 133 SFISYqySWLFFLSRGFVGTGAASYSTIAPTVLGDLFVKDQRTCALAVFYIFIPVGSGLGYVLGSTVAELTGNWRWALRL 212
Cdd:cd17328  82 SFAPN--FWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWRWAFRV 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 213 MPCLDAMALALLILLVPDVPRGAAEkqGEVAVRAPRSSWCEDVRYLGRNWSFVFSTLGVTAIAFVTGALGFWAPKFLFEA 292
Cdd:cd17328 160 TGVLGVLLAILLLLFVREPPRGAAE--GGVMAKSTATSFLADLKALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRA 237

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 293 RVVHGLQLpcfqeqchSQDSLIFGALTVATGIIGVMLGAEASRRYKKVNPRAEPLICASSLFATAPCLYLALILASRTLL 372
Cdd:cd17328 238 FGVGDLSS--------ADVGLIFGAITCIAGVLGVLLGGILADRLRRKTPRADPLVCAVGLLAAAPFLFLALVLALSNLL 309

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 373 ASYVFLALGELLLSCNWAVVADILLSVVVPRCRGTAEALQITVAHVLGDAGSPYLTGLISSVLqAERPDSYLQHFLSLQH 452
Cdd:cd17328 310 LAWVLLFLGEFLLSLNWAPVFAILLYVVIPTRRSTASAIQILLSHLLGDAGSPYLIGLISDLL-RQNKDSPLAEAASLQY 388

                       410
                ....*....|....*..
gi 58037493 453 SFLCCAFAIVLGGGFFL 469
Cdd:cd17328 389 ALLLCSFVLVLGGFFFL 405
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
42-477 1.82e-28

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 116.12  E-value: 1.82e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493  42 SLPRWRAYLAAAVLCYINLLNYMNWFIIPGVLLDVQKYFHISDSHAGLLQTVFISCLLVSAPVFGYLGDRYNRKAILSFG 121
Cdd:COG2271   2 RAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 122 ILLWSGAGLSSSFIsyQYSWLFFLSRGFVGTGAASYSTIAPTVLGDLFVKDQRTCALAVFYIFIPVGSGLGYVLGSTVAE 201
Cdd:COG2271  82 LLLWGLATLLFGFA--TSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLA 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 202 LTGnWRWALRLMpcldamalallillvpdvprGAAekqgeVAVRAPrsswcedvrylgrnWSFVFSTLGVTAIAFVTGAL 281
Cdd:COG2271 160 AFG-WRAAFLIL--------------------GLP-----GLLLAL--------------LRFWLLALAYFLVYFALYGF 199

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 282 GFWAPKFLFEarvVHGLQLpcfqeqchsQDSLIFGALTVATGIIGVMLGAEASRRYKkvnpRAEPLICASSLFATAPCLY 361
Cdd:COG2271 200 LTWLPTYLVE---VRGLSL---------AQAGLLLSLPFLAGIVGSLLGGWLSDRLG----RRRKLVLAIGLLLAALALL 263

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 362 LALILASRTLLasYVFLALGELLLSCNWAVVADILLSVVVPRCRGTAEALqITVAHVLGDAGSPYLTGLISSvlqaerpd 441
Cdd:COG2271 264 LLALLPSPALA--IALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGL-VNTFGFLGGALGPLLVGYLLD-------- 332

                       410       420       430
                ....*....|....*....|....*....|....*.
gi 58037493 442 sylqhFLSLQHSFLCCAFAIVLGGGFFLLTALHLEK 477
Cdd:COG2271 333 -----ATGYQAAFLLLAALALLAALLALLLLRETRK 363
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 55-469 9.23e-24

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 102.89  E-value: 9.23e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493  55 LCYINLLNYMNWFIIPGVLLDVQKYFHISDSHAGLLQTVFISCLLVSAPVFGYLGDRYNRKAILSFGILLWS-GAGLSSS 133
Cdd:cd06174   1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFAlGALLFAF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 134 FISYqysWLFFLSRGFVGTGAASYSTIAPTVLGDLFVKDQRTCALAVFYIFIPVGSGLGYVLGS-TVAELTGNWRWALRL 212
Cdd:cd06174  81 APSF---WLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGiLASSLGFGWRAVFLI 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 213 MPCLDAMALALLILLVPDVPRGAAEKQGEvavrAPRSSWCEDVRYLGRNWSFVFSTLGVTAIAFVTGALGFWAPKFLFEa 292
Cdd:cd06174 158 AAALALLAAILLLLVVPDPPESARAKNEE----ASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLD- 232

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 293 rvvhglqlpcfQEQCHSQDSLIFGALTVATGIIGVMLGAEASRRYKKVNpraePLICASSLFATAPCLYLALILASRTLL 372
Cdd:cd06174 233 -----------LGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRK----PLLLIGLLLMALGLALLLLAPSLLLLL 297

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 373 ASYVFLALGELLLSCNWAVVADILlsvVVPRCRGTAEALQITVAHVLGDAGSPYLTGLISsvlqaerpdsylqHFLSLQH 452
Cdd:cd06174 298 LLLLLLGFGLGGLLPLSFALIAEL---FPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLA-------------ATFGLTG 361

                       410
                ....*....|....*..
gi 58037493 453 SFLCCAFAIVLGGGFFL 469
Cdd:cd06174 362 AFLVLAVLLLLAAILLL 378
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
44-422 2.15e-23

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 101.20  E-value: 2.15e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493  44 PRWRAYLAAAVLCYINLLNYMNWFIIPGVLLDVQKYFHISDSHAGLLQTVFISCLLVSAPVFGYLGDRYNRKAILSFGIL 123
Cdd:COG2814   4 TPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 124 LWSGAGLSSSFIsyQYSWLFFLSRGFVGTGAASYSTIAPTVLGDLFVKDQRTCALAVFYIFIPVGSGLGYVLGSTVAELT 203
Cdd:COG2814  84 LFALGSLLCALA--PSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 204 GnWRWALRLMPCLDAMALALLILLVPDVPrgaaekqgevavRAPRSSWCEDVRYLGRNWSFVFSTLGVTAIAFVTGALGF 283
Cdd:COG2814 162 G-WRWVFLVNAVLALLALLLLLRLLPESR------------PAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFT 228

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 284 WAPKFLFEarvVHGLQlpcfqeqchSQDSLIFGALTVATGIIGVMLGAEASRRYkkvnpRAEPLICASSLFATAPCLYLA 363
Cdd:COG2814 229 YLPLYLQE---VLGLS---------ASAAGLLLALFGLGGVLGALLAGRLADRF-----GRRRLLLIGLLLLALGLLLLA 291

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 58037493 364 LILASRTLLASYVFLALGELLLscnWAVVADILLSVVVPRCRGTAEALQITVAHVLGDA 422
Cdd:COG2814 292 LAGSLWLLLLALFLLGFGFGLL---FPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
MFS_1 pfam07690
Major Facilitator Superfamily;
55-418 5.97e-22

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 97.10  E-value: 5.97e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493    55 LCYINLLNYMNWFIIPGVL-LDVQKYFHISDSHAGLLQTVFISCLLVSAPVFGYLGDRYNRKAILSFGILLWSGAGLSSS 133
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALpLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493   134 FISyqYSWLFFLSRGFVGTGAASYSTIAPTVLGDLFVKDQRTCALAVFYIFIPVGSGLGYVLGSTVAELTGnWRWALRLM 213
Cdd:pfam07690  81 FAS--SLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG-WRAAFLIL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493   214 PCLDAMALALLILLVPDVPRGAAEKQGEVAVRAPrsswcEDVRYLGRNWSFVFSTLGVTAiAFVTGALGFWAPKFLfear 293
Cdd:pfam07690 158 AILSLLAAVLLLLPRPPPESKRPKPAEEARLSLI-----VAWKALLRDPVLWLLLALLLF-GFAFFGLLTYLPLYQ---- 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493   294 VVHGLQLpcfqeqchsQDSLIFGALTVATGIIGVMLGAEASRRYKKVNPRAepLICASSLFATAPCLYLALILASRTLLA 373
Cdd:pfam07690 228 EVLGLSA---------LLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLL--LALLLLILAALGLLLLSLTLSSLWLLL 296

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 58037493   374 SYVFLALGellLSCNWAVVADILLSVVVPRCRGTAEALQITVAHV 418
Cdd:pfam07690 297 ALLLLGFG---FGLVFPALNALVSDLAPKEERGTASGLYNTAGSL 338
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 53-471 7.21e-17

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 82.23  E-value: 7.21e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493  53 AVLCYINLLNYMNWFIIPGVLLDVQKYFHISDSHAGLLQTVFISCLLVSAPVFGYLGDRYNRKAILSFGILLWS----GA 128
Cdd:cd17474   2 YAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGigglLC 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 129 GLSSSFisyqysWLFFLSRGFVGTGAASYSTIAPTVLGDLFVKDQRTCALAVFYIFIPVGSGLGYVLGSTVAELTgnWRW 208
Cdd:cd17474  82 GLSDSF------ALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAIS--WRY 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 209 ALRLMPCLDAMALALLILLVPDVPRGaAEKQGEVAVRAPRsswcedvRYLGRNWSFVFSTLGVTAIaFVTGALGFWAPKF 288
Cdd:cd17474 154 PFFLLAALIPVAFLAILFLLPEPKEK-AKSSSATKLRDLK-------KALRGRGLLTFLVSAFLYF-FLYFAFLTYLPFL 224

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 289 LFEARVVHGLQLpcfqeqchsqdSLIFGALTVATGIIGVMLGAEASRRYkkvnpRAEPLICASSLFATApCLYLALILAS 368
Cdd:cd17474 225 LELLYGISPIII-----------GLLFAGWSVLLALGSLFVGRLLKKRF-----GARRILVIGLLLYAL-SLLLLGFVPS 287

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 369 RTLLAsyVFLALGELLLSCNWAVVADILLSVVVPRCRGTAEALQITVAHvLGDAGSPYLTGLISSvlqaerpdsylqhFL 448
Cdd:cd17474 288 LALLL--IAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRF-LGQAVGPLLFGLLLE-------------IF 351

                       410       420
                ....*....|....*....|...
gi 58037493 449 SLQHSFLCCAFAIVLGGGFFLLT 471
Cdd:cd17474 352 GLSAPFLVGAAIALAAAVLLALL 374
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 36-295 1.15e-14

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 74.46  E-value: 1.15e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493  36 STPVPWSLPRWRAYLAAAVLcyiNLLNYMNWFIIPGVLLDVQKYFHISDSHAGLLQTVFISCLLVSAPVFGYLGDRYNRK 115
Cdd:COG0477   3 STDAAPTRRRRRALLALALG---TFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRK 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 116 AILSFGILLWS----GAGLSSSFisyqysWLFFLSRGFVGTGAASYSTIAPTVLGDLFVKDQRTCALAVFYIFIPVGSGL 191
Cdd:COG0477  80 RVLLIGLLLFGlaslLCGLAPSP------ELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLAL 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 192 GYVLGSTVAELTGnWRWALrLMPCLDAMALALLILLVPDVPRGAAEKQGEVAVRAPRSSWCEDVRYLGRNWSFVFSTLGV 271
Cdd:COG0477 154 GPLLGGLLVAALG-WRWIF-LINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLA 231

                       250       260
                ....*....|....*....|....
gi 58037493 272 TAIAFVTGALGFWAPKFLFEARVV 295
Cdd:COG0477 232 LLLAGAALLLLLALLLLALLLLLA 255
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 67-213 7.56e-14

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 72.97  E-value: 7.56e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493  67 FIIPGVLLDVQKYFHISDSHAGLLQTVFISCLLVSAPVFGYLGDRYNRKAILSFGILLWSGAGLSSSFiSYQYsWLFFLS 146
Cdd:cd17324  16 YVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAAL-APSF-ALLLLA 93

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 58037493 147 RGFVGTGAASYSTIAPTVLGDLFVKDQRTCALAVFYIFIPVGSGLGYVLGSTVAELTGnWRWALRLM 213
Cdd:cd17324  94 RALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLG-WRAAFLAI 159
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 45-470 2.33e-13

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 71.45  E-value: 2.33e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493  45 RWRAyLAAAVLCYInlLNYMNWFIIPGVLLDVQKYFHISDSHAGLLQTVFISCLLVSAPVFGYLGDRYNRKAILSFGILL 124
Cdd:cd17319   1 RWRI-IPLLFLAYV--INYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 125 WSGAGLSSSFIsyQYSWLFFLSRGFVGTGAASYSTIAPTVLGDLFVKDQRTCALAVFYIFIPVGSGLGYVLgSTVAELTG 204
Cdd:cd17319  78 WSLFTALTGFA--TSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPL-SGWLLLLF 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 205 NWRWALRLMpcldamalallilLVPDVPRGAAekqgevavraprssWcedVRYLGRNWSFVFSTLGvtaIAFVTGALGFW 284
Cdd:cd17319 155 GWRWAFIIE-------------GLLGLLLAVL--------------W---WFYLRQVWGLALGYFG---INYALYGLLTW 201

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 285 APKFLFEARVVHGLQLpcfqeqchsqdslifGALTVATGIIGVMLGAEASRRYKKVNPRAEPLICASSLFATAPCLYLAL 364
Cdd:cd17319 202 LPTYLKQARGFSLKQV---------------GLLAAIPFLAGAIGMILGGRLSDRLLRGARRLVIIIGLLLAAVGLLLAY 266

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 365 ILASrtLLASYVFLALGELLLSCNWAVVADILLSVVVPRCRGTAEALqITVAHVLGDAGSPYLTGLIssvlqaerpdsyL 444
Cdd:cd17319 267 LTTS--PVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGL-INSGGNLGGFVAPLLIGYL------------V 331

                       410       420
                ....*....|....*....|....*.
gi 58037493 445 QHFLSLQHSFLCCAFAIVLGGGFFLL 470
Cdd:cd17319 332 DATGSYTAAFLFLAAVALLAALLVLL 357
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
45-471 2.90e-12

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 68.37  E-value: 2.90e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493  45 RWRAyLAAAVLCYinLLNYMNWFIIPGVLLDVQKYFHISDSHAGLLQTVFISCLLVSAPVFGYLGDRYNRKAILSFGILL 124
Cdd:COG2223   3 RWRV-LLLATLAF--FLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 125 WSGAGLSSSF-ISYqysWLFFLSRGFVGTGA-ASYSTIAPTVlGDLFVKDQRTCALAVFYIFIPVGSGLGYVLGSTVAEL 202
Cdd:COG2223  80 LGIGLLLLALaVSY---WLLLLLGLLLGIGGgGSFAVGIALV-SKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAA 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 203 TGnWRWALRLMPCLDAMALALLILLVPDVPRGAAEkqgevAVRAPRSSWCEDVRYlGRNWSFVFsTLGVTAIAFVtgALG 282
Cdd:COG2223 156 FG-WRNAFLILGILLLVVAVLAWLFLRDPPAGAAA-----AAKASLRDQLEALRD-PRFWLLSL-LYFGTFGSFI--GFS 225

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 283 FWAPKFLFEarvVHGLQLPcfqeqchsqDSLIFGALTVATGIIGVMLGAEASRRYKKVNpraepLICASSLFATAPCLYL 362
Cdd:COG2223 226 SWLPPYLVD---QFGLSAA---------TAGLLAALFALLGALGRPLGGWLSDRIGGRR-----VLLIVFALMALGLLLL 288

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 363 ALILASRTL---LASYVFLALGeLLLSCNWAVVADILLsvvvPRCRGTAEALqITVAHVLGDAGSPYLTGLIssvlqaer 439
Cdd:COG2223 289 ALALGSLWLflvLFLLLGLALG-GGNGAVFALVPDIFP----TKNAGAVYGL-VGAAGGLGGFLGPLLFGAL-------- 354

                       410       420       430
                ....*....|....*....|....*....|..
gi 58037493 440 pdsyLQHFLSLQHSFLCCAFAIVLGGGFFLLT 471
Cdd:COG2223 355 ----LDATGSYTAAFLVFAVLALVALVLTLLL 382
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 68-472 5.26e-12

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 67.20  E-value: 5.26e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493  68 IIPGVLLDVQKYFHISDSHaglLQTVFISCLLVSA---PVFGYLGDRYNRKAILSFGILLWSGA----GLSSSFisyqys 140
Cdd:cd17321  14 IVNVALPTIARDLGASPSQ---LQWVVNAYLLAFAallLLAGRLGDRFGRKRVFLIGLALFGLAsllcALAPSL------ 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 141 WLFFLSRGFVGTGAASYSTIAPTVLGDLFVKDQRTCALAVFYIFIPVGSGLGYVLGSTVAELTGnWRWALRLMpcldama 220
Cdd:cd17321  85 AFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFG-WRWIFLIN------- 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 221 lallillvpdVPRGAAekqgevavraprsswcedVRYLGRNwsFVFSTLGVTAIAFVTGALGFWAPKFLfeaRVVHGLql 300
Cdd:cd17321 157 ----------VPIGLV------------------ALLLART--FSGAVLAAFLLGAALGGLLFLLPLYL---QGVLGY-- 201

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 301 pcfqeqchsqDSLIFGALTVATGIIGVMLGAEASRRYKKVNPRaePLICASSLFATAPCLYLALILASRTLLASYVFLAL 380
Cdd:cd17321 202 ----------SPLQAGLALLPLALAMLVAAPLAGRLADRFGPR--LVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVL 269

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 381 GELLLSCNWAVVADILLSVVVPRCRGTAEALqITVAHVLGDA-GSPYLTGLISSVLQAERPDSYLQHFLSLQHSFLCCAF 459
Cdd:cd17321 270 LGLGLGLFATPLTNAALSSVPKEKAGAASGI-LNTARQLGGAlGVALLGALLTAGLSANLGDSGVAALLSAAAAAFAAGF 348

                       410
                ....*....|...
gi 58037493 460 AIVLGGGFFLLTA 472
Cdd:cd17321 349 HLAFLVAAALALL 361
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 55-470 1.46e-11

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 66.06  E-value: 1.46e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493  55 LCYINLLNYMNWFIIPGVLLDVQKYFHISDSHAGLLQTVFISCLLVSAPVFGYLGDRYNRKAILSFGILLWSGA----GL 130
Cdd:cd17325   1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVStllfAF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 131 SSSFisyqysWLFFLSRGFVGTGAASYSTIAPTVLGDLFVKDQRTCALAVFYIFIPVGSGLGYVLGSTVAELTGnWRWAL 210
Cdd:cd17325  81 ATSY------WQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALG-YRAPF 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 211 RLMPCLDAMALALLILLVPDvPRGAAEKQGEVAVRAPRSSWcedvrYLGRNWSFVFSTLGVTAIAFVTGALGFWAPKFLF 290
Cdd:cd17325 154 LVCAALALLALVLALLLLPE-PRPPPNKRAVSAARLRSGLR-----LLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAA 227

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 291 EarvVHGLQLpcfqeqchSQDSLIFGALTVATGIIGVMLGAEASRRYKKvnpraePLICASSLFATAPclyLALILASRT 370
Cdd:cd17325 228 E---LGGLSP--------AQIGLLFGAQGLASALSQPPAGKLSDRIGRK------PLILIGLLLSAVA---LLLLPLATS 287

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 371 LLASYVFLALGELLLSCNWAVVADILLSVVVPRCRGTAEALqITVAHVLGDAGSPYLTGLISSvlqaerpdsylqhFLSL 450
Cdd:cd17325 288 FWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGL-FNTAFSLGMVLGPLLGGFLYD-------------AFGF 353

                       410       420
                ....*....|....*....|
gi 58037493 451 QHSFLCCAFAIVLGGGFFLL 470
Cdd:cd17325 354 ATPFLAAAALLLLAAVLFLL 373
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 53-208 1.66e-11

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 65.67  E-value: 1.66e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493  53 AVLCYINLLNYMNWFIIPGVLLDVQKYFHISDSHAGLLQTVFISCLLVSAPVFGYLGDRYNRKAILSFGILLWS----GA 128
Cdd:cd17323   2 FIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVifqiGC 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 129 GLSSSFisyqysWLFFLSRGFVGTGAASYSTIAPTVLGDLFVKDQRTCALAVFYIFIPVGSGLGYVLGSTVAELTGnWRW 208
Cdd:cd17323  82 ALAPNI------AMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLG-WRW 154
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
72-465 5.41e-11

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 64.49  E-value: 5.41e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493  72 VLLDVQKYFHISDSHAGLLQTVFISCLLVSAPVFGYLGDRYNRKAILSFGILLwSGAGLSSSFISYQYsWLFFLSRGFVG 151
Cdd:COG0738  30 LIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLL-MALGLLLFALAPSY-PLLLLALFLLG 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 152 TGAASYSTIAPTVLGDLFVKDQRTcALAVFYIFIPVGSGLGYVLGSTV--AELTGNWRWALRLM-PCLDAMALALLILLV 228
Cdd:COG0738 108 LGLGLLDVAANPYVAALGPETAAS-RLNLLHAFFSLGALLGPLLGGLLilLGLSLSWHLPYLILaVLLLLLALLFLRSKL 186

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 229 PDVPRGAAEKQGEVAvraprsswceDVRYLGRNWSFVFSTLGVTAIAFVTGALGFWAPKFLFEarvVHGLQLpcfqeqch 308
Cdd:COG0738 187 PEIEEEEEEAAGSAA----------SLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKD---VLGLSE-------- 245

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 309 sQDSLIFGALTVATGIIGVMLGAEASRRYKkvnprAEPLICASSLFATApcLYLALILASRTLLASYVFLALGeLLLSCN 388
Cdd:COG0738 246 -ATAALGLSLFWGGMTIGRFLGGFLLKRFG-----PVRLLRLSALLAAV--GLLLALLAPGPWLALIGLALVG-LGLSLM 316

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 389 WAVVADILLSvVVPRCRGTAEALQITVAhVLGDAGSPYLTGLISsvlqaerpdsylqHFLSLQHSFL----CCAFAIVLG 464
Cdd:COG0738 317 FPTIFSLALD-GLGKRTAAAVSAVLIMG-IVGGAIGPPLIGFLA-------------DAFGLRAAFLvplvCYLLILLLA 381


                .
gi 58037493 465 G 465
Cdd:COG0738 382 L 382
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 60-469 3.26e-10

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 61.80  E-value: 3.26e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493  60 LLNYMNWFIIPGVLLDVQKYFHISDSHAGLLQTVFISCLLVSAPVFGYLGDRYNRKAILSFGILLWsGAGLSSSFISYQY 139
Cdd:cd17478   6 FLNDFYQGFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLT-GLGLSLLGFAPNY 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 140 SWLFFLSrGFVGTGAASYSTIAPTVLGDLFvKDQRTCALAVFYIFIPVGSGLGYVLGSTVAELTGNWRWALRLMPCLDAM 219
Cdd:cd17478  85 WLLLLLV-ALAGIGSAAFHPEGARLASQAA-GGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAV 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 220 ALALLILLVPDVPRGAAEKQGEVAVRAPRSSWcedvrylgrnWSFVFSTLGVTAIAFVTGALGFWAPKFLfearVVHGLq 299
Cdd:cd17478 163 ALLLLRLRPLKKPEAKKAAAKSSARSTLKGVW----------RALLLLLIIVFLRSWVLSSLTTFLPFYL----VQRGY- 227

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 300 lpcfqeqchsqdSLIFGALTVAT----GIIGVMLGAEASRRYKKVNpraeplICASSLFATAPCLYLALILasrTLLASY 375
Cdd:cd17478 228 ------------SLVFAGLLLSLflfaGAIGTLIGGPLSDRFGRRR------VIIASLLLAAPFLLLFLLT---PGIWSY 286

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 376 VFLALGELLLSCNWAVvadiLLSVV---VPRCRGTAEALQITVAHVLGDAGSPyLTGLISSVlqaerpdsylqhfLSLQH 452
Cdd:cd17478 287 ILLVLAGFLLFASFPV----TVVLAqelLPGNVGLASGLMMGLSFGLGGIGAP-VLGALADA-------------FGLES 348

                       410
                ....*....|....*..
gi 58037493 453 SFLCCAFAIVLGGGFFL 469
Cdd:cd17478 349 VLLILALLPLLGALLAF 365
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 54-209 4.12e-10

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 61.44  E-value: 4.12e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493  54 VLCYINLLNYMNWFIIPGVLLDVQKYFH-ISDSHAGLLQTVFISCLLVSAPVFGYLGDRYNRKAILSFGILLWSGAGLSS 132
Cdd:cd17473   3 TLLLASTLTVMAGAAIAPALPAIAQHFVpNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAG 82

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 58037493 133 SFI-SYqysWLFFLSRGFVGTGAASYSTIAPTVLGDLFVKDQRTCALAVFYIFIPVGSGLGYVLGSTVAELtgNWRWA 209
Cdd:cd17473  83 LFLdSL---YALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEI--GWRAP 155
MFS_SLCO4_OATP4 cd17403
Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of ...
 68-338 1.24e-09

Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4 (SLCO4) or Organic anion transporting polypeptide 4 (OATP4) family contains two families: OATP4A and OATP4C, each containing one mammalian member, OATP4A1 and OATP4C1, respectively. OATP4A1 (encoded by SLCO4A1), is ubiquitously expressed and mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4C1 (encoded by SLCO4C1) is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate, cAMP, and uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs). The SLCO4/OATP4 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340961 [Multi-domain]  Cd Length: 420  Bit Score: 60.34  E-value: 1.24e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493  68 IIPGVLLDVQKYFHISDSHAGLLQTVF-ISCLLVSAPVfGYLGDRYNRKAILSFGILLwsgAGLSSSFISYQYSWLFFLS 146
Cdd:cd17403  22 FVNVSITTIEKRFGLTSTQTGLIASSYdIASVLLLLFV-SYFGGRGHKPRWLGIGAFI---MGIGSLVFALPHFTVFILA 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 147 RGFVGTGAASYSTIAPTVLgDLFVKDQRTCA-LAVFYIFIPVGSGLGYVLGSTVAELTGNWrwalrlmpcldamalalli 225
Cdd:cd17403  98 QLLHGAGATPLYTLGVTYL-DENVSTKMSPLyIGIFYAMAILGPAIGYVLGGFLLNLYTDI------------------- 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 226 llvpdvprGAAEKQGEVAVRAPR--------------SSWCEDVRYLGRNWSFVFSTLGVTAIAFVTGALGFWAPKFLFE 291
Cdd:cd17403 158 --------DQVDSELGLTPDDPRwvgawwlgflisgaLALIIAFPLLGFPPTFMFLNLAGASEGMLLAGFATFLPKLIES 229

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 58037493 292 ArvvhgLQLPCfqeqchSQDSLIFGALTVATGIIGVMLGAEASRRYK 338
Cdd:cd17403 230 Q-----FSLSA------SLAALLVGVVVVPGGILGTFLGGLIVKKLK 265
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
54-204 2.01e-09

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 59.53  E-value: 2.01e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493  54 VLCYINLLNYMNWFIIPGVLL-DVQKYFHISDSHAGLLQTVFISCLLVSAPVFGYLGDRYNRKAILSFGILLWSGAGLSS 132
Cdd:COG2211 232 LLLLAYLLFFLALALVAALLLyYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLL 311

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 58037493 133 SFISYQYSWLFFLSRGFVGTGAASYSTIAPTVLGDLFVKDQRTC-------ALAVFYIFIPVGSGLGYVLGSTVAELTG 204
Cdd:COG2211 312 FFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTgrrreglYFGIFTFAIKLGQALAGALAGLLLALFG 390
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 50-213 4.66e-09

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 58.36  E-value: 4.66e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493  50 LAAAVLcyinLLNYMNWFIIPgVLLDVQKYFHISDSHAGLLQTVFISCLLVSAPVFGYLGDRYNRKAILSfGILLWSGAG 129
Cdd:cd17504   1 LALAAL----AVMLVETMLSP-ALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLL-IVLAIYTAG 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 130 LSSSFISYQYSWLFFlSRGFVGTGAASYsTIAPTVLGDLFVKDQRTCALAVFYIFIPVGSGLGYVLGSTVAELTGnWRWA 209
Cdd:cd17504  75 SLLAAFAPNLPVLIA-GRALQGIGGAVF-PLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLG-WRWI 151


                ....
gi 58037493 210 LRLM 213
Cdd:cd17504 152 FWTA 155
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 86-208 1.82e-08

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 56.05  E-value: 1.82e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493  86 HAGLLQTVFISCLLVSAPVFGYLGDRYNRKAILSFGILLWSGAGLSSSFISyqYSWLFFLSRGFVGTGAASYSTIAPTVL 165
Cdd:cd17317  26 LVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSP--SYELFLVLRFLVGVTSAGIFTVGFVLG 103

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 58037493 166 GDLFVKDQRTCALAVFYIFIPVgsglGYVLGSTVAELTGNWRW 208
Cdd:cd17317 104 MEIVGPKYRSFVGILFGLFWAL----GYMLLALLAYLIRDWRW 142
MFS_SLCO_OATP cd17336
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ...
 52-197 3.23e-08

Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340894 [Multi-domain]  Cd Length: 411  Bit Score: 55.71  E-value: 3.23e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493  52 AAVLCYINLLNYMNWFIIPGVLLDVQKYFHISDSHAGLLQTVF-ISCLLVSAPVfGYLGDRYNRKAILSFGILLWSGAGL 130
Cdd:cd17336   5 VVLLCLLGLLQGAVVSYFVSTITTIEKRFGLSSSQSGLILSANdIGQLLAVLLV-SYFGGRGHRPRWIGIGSILMGLGCF 83

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 58037493 131 SSSFISYqyswlFFLSRGFVGTGAASYSTIAPTVLGDlFVKDQRTCA-LAVFYIFIPVGSGLGYVLGS 197
Cdd:cd17336  84 LLALPHF-----LFVGQFLLGIGSSPLYTLGITYIDD-NVSKKNSPLyIGILYAMRVLGPALGFLLGS 145
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 87-208 3.32e-08

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 55.79  E-value: 3.32e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493    87 AGLLQTVFISCLLVSAPVFGYLGDRYNRKAILSFGILLWSGAGLSSSFiSYQYSWLFFLsRGFVGTGAASYSTIAPTVLG 166
Cdd:TIGR00898 129 VDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAF-SPNYTVFLVF-RLLVGMGIGGIWVQAVVLNT 206

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 58037493   167 DLFVKDQRtcalAVFYIFIPVGSGLGYVLGSTVAELTGNWRW 208
Cdd:TIGR00898 207 EFLPKKQR----AIVGTLIQVFFSLGLVLLPLVAYFIPDWRW 244
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
34-210 3.46e-08

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 55.65  E-value: 3.46e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493  34 PPSTPVPWSLPRWRAyLAAAVLCYINLlnYMNWFIIPGVLLDVQKYFHISDSHAGLLQTVFISCLLVSAPVFGYLGDRY- 112
Cdd:COG2807   5 SSSARRSRRAGRWLL-LLAIVLVALNL--RPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFg 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 113 NRKAILSFGILLWSGAGLSSSFISYqysWLFFLSRGFVGTGAASYSTIAPTVLGDLFvKDQRTCALAVFYIFIPVGSGLG 192
Cdd:COG2807  82 LERTLLLALLLLAAGLLLRSLAPSV---ALLLAGTALIGAGIAVGNVLLPGLIKRWF-PDRVGLMTGLYTAAMGLGAALA 157

                       170
                ....*....|....*...
gi 58037493 193 YVLGSTVAELTGnWRWAL 210
Cdd:COG2807 158 AGLTVPLAAALG-WRGAL 174
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 35-204 3.58e-08

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 55.27  E-value: 3.58e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493  35 PSTPVPWSLPRWRAYLAAAVLcyINLLNYMNWFIIPGVLLDVQKYFHISDSHAGLLQTVFISCLLVSAPVFGYLGDRYNR 114
Cdd:cd17325 187 RLRSGLRLLLRDRRLLALFLA--IFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGR 264

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 115 KAILSFGILLWSGAGLSSSFISYQysWLFFLSRGFVGTGAASYSTIAPTVLGDLFVKDQRTCALAVFYIFIPVGSGLGYV 194
Cdd:cd17325 265 KPLILIGLLLSAVALLLLPLATSF--WLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPL 342

                       170
                ....*....|
gi 58037493 195 LGSTVAELTG 204
Cdd:cd17325 343 LGGFLYDAFG 352
MFS_DtpA_like cd17346
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ...
 80-209 2.21e-07

Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340904 [Multi-domain]  Cd Length: 399  Bit Score: 52.96  E-value: 2.21e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493  80 FHISDSHAGLLQTVFISCLLVSAPVFGYLGDRY--NRKAILSFGILLwsGAGLSSSFISYQYSWLFFLSRGFVGTGAASY 157
Cdd:cd17346  35 DGFSEADAASIYGAYTALVYLTPIIGGWLADKVlgARRTVFIGGILM--ALGYLLLALSPFSVSMLYLGLALIIVGNGLF 112

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 58037493 158 STIAPTVLGDLFVKDQ--RTCALAVFYIFIPVGSGLGYVLGSTVAElTGNWRWA 209
Cdd:cd17346 113 KPNISSLVGKLYDENDprRDSGFSIFYMGINLGAFLAPLLCGTLGD-NYGYHYG 165
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
 64-212 2.32e-07

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 52.92  E-value: 2.32e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493  64 MNWFIIPGVLLDVQKYFHISDSHAGLLQTVFISCLLVSAPVFGYLGDRYNRKAILSFGILLWSGAGLSSSFiSYQYSWLF 143
Cdd:cd17372  13 MEMMLLSFVGPAVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAF-APNYMWLI 91

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 58037493 144 FLsRGFVGTGAASYSTIAPTVLGDLFVKDQRTCaLAVFYIFIPVGSGLGYVLGSTVAELTGnWRWALRL 212
Cdd:cd17372  92 IL-RCLVGLGLGGGPQLASWYLEFLPAKSRGTW-MVLFSVFWTVGTIFEASLAWLVMPRLG-WRWLLAF 157
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 60-200 3.19e-07

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 52.20  E-value: 3.19e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493  60 LLNYMNWFIIPGVLLDV---QKYFHISDSHAGLLQTVFISCLLVSAPVFGYLGDRYNRKAILSFGILlwsGAGLSSSFIS 136
Cdd:cd17330   6 FLDALGFGIVFPVLPFYvreFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLA---GSAVSYVLLG 82

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 58037493 137 Y-QYSWLFFLSRGFVGTGAASYSTIApTVLGDLFVKDQRTCALAVfyifIPVGSGLGYVLGSTVA 200
Cdd:cd17330  83 LsRNLWLLFLARFLDGLTGGNVSVAQ-AYIADITDEEERAKAFGI----ISAAFGLGFILGPALG 142
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 58-210 4.54e-07

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 51.83  E-value: 4.54e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493  58 INLLNYMNWFIIPGVLLDVQKYF--HISDSHAGLLQTVFISCLLVSAPVFGYLGDRYNRKAILSFGILLWSGAGLSSSFI 135
Cdd:cd17316   7 GWFFDAYDFFLIGFVAPVLAAEFslGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLL 86

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 58037493 136 SyqYSWLFFLSRGFVGTGAASYSTIAPTVLGDLFVKDQRTCALAVFYIFIPVGSGLGYVLGSTVAELTG---NWRWAL 210
Cdd:cd17316  87 P--TPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSgdwGWRILF 162
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 55-204 4.90e-07

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 51.83  E-value: 4.90e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493  55 LCYINLLNYMNWFI----IPGVLLDvqkyFHISDSHAGLLQTVFISCLLVSAPVFGYLGDRYNRKAILSFGILLwsgagL 130
Cdd:cd17489   1 ILLANFFFFLSFYLllpvLPLYAHD----LGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLI-----F 71

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 58037493 131 SSSFISYQYS---WLFFLSRGFVGTGAASYSTIAPTVLGDLFVKDQRTCALAVFYIFIPVGSGLGYVLGSTVAELTG 204
Cdd:cd17489  72 ALATLLYLLAtsvALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLG 148
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 58-440 1.18e-06

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 50.69  E-value: 1.18e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493  58 INLLNYMNWF-IIPGVLLDVQKYFHISDSHAGLLQTVFISCLLVSAPVFGYLGDRYNRKAILSFGILLWSGAGLssSFIS 136
Cdd:cd17329   7 GSFLNRLGFFmVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFA--LLGF 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 137 YQYSWLFFLSRGFVGTGAASYSTIAPTVLGDLFVKDQRTCALAVFYIFIPVGSGLGYVLGSTVAELtgNWRWALRLMPCL 216
Cdd:cd17329  85 AHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY--SFRLLFLAAAVL 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 217 DAMALALLILLVPDVPRGAAEKQGEVAVRAPRSswcedvryLGRNWSFVFSTLGVTAIAFVTGALGFWAPKFLfearvvh 296
Cdd:cd17329 163 FLLAALVLLFLLPETRPKRRAAEKTEILRGYKI--------VLRDRAFLLFLLASFLISLIYFQLESTLPVYV------- 227

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 297 glqlpcfQEQCHSQDSLIFGALTVATGIIgVMLGAEASRRYKKVNPRAepLICASSLFATAPCLYLALILASRTLLASYV 376
Cdd:cd17329 228 -------VEILGLGESLLGLLLALNALLI-VLLQFPVARLVERFRLRK--ILMIGILLFAIGFAVLAFANTLAVLILAMI 297

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 58037493 377 FLALGELLLscnWAVVADILLSVVVPRCRGTAEALQITVAHvLGDAGSPYLTGLISSVLQAERP 440
Cdd:cd17329 298 VLTLGEMLV---FPAVQTLVAALAPPDKRGSYMGFYALAWG-LGRAIGPLVGGLLLDLLGPGLP 357
MFS_SVOPL cd17442
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ...
 80-212 8.36e-06

Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341000 [Multi-domain]  Cd Length: 375  Bit Score: 47.88  E-value: 8.36e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493  80 FHISDSHAGLLQTVFISCLLVSAPVFGYLGDRYNRKAILSFGILLWSGAGLSSSFiSYQYSWLFFLsRGFVGTGAASYST 159
Cdd:cd17442  31 WHLEDWQVALVTTMVFFGYMVFSILLGLLADRYGRWKILLLSFVWGAYFSLLTSF-APSYIWFVFL-RCMVGCGVSGHSQ 108

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 58037493 160 iAPTVLGDLFVKDQRTCALAVFYIFIPVGSGLGYVLGSTVAELTGnWRWALRL 212
Cdd:cd17442 109 -GLIIKTEFLPTKYRGYMLPLSQIFWLAGSLLIIGLASVVIPTLG-WRWLIRF 159
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 54-208 1.03e-05

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 47.55  E-value: 1.03e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493  54 VLCYI-NLLNYMNWFIIPGVLLDVQKYFHISDSHAGLLQTVFISCLLVSAPVFGYLGDRYNRKAILSFGILLWSGAGLSS 132
Cdd:cd17380   2 ILLFLaTCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLT 81

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 58037493 133 SFISYQYSWLFFLSRGFVGTG-AASYSTIApTVLGDLFVKDQRTCALAVFYIFIPVGSGLGYVLGSTVAELTGnWRW 208
Cdd:cd17380  82 PLLAYSSLPLLILSRILLGLGeGVHFPSMT-SLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYG-WPS 156
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 87-208 2.15e-05

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 46.45  E-value: 2.15e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493  87 AGLLQTVFISCLLVSAPVFGYLGDRYNRKAILSFGILLWSGA----GLSSSFIsyqyswLFFLSRGFVGTGAASySTIAP 162
Cdd:cd17390  33 IGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGyvllGFSTSLA------LLFLSRIPLGIFKHT-QSLCK 105

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 58037493 163 TVLGDLFVKDQRTCALAVFYIFIPVGSGLGYVLGSTVAELTGNWRW 208
Cdd:cd17390 106 AYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETDGGFYY 151
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 45-206 3.57e-05

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 46.06  E-value: 3.57e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493  45 RWRAYLAAAVLCYINLLNYMNWFIIPGVLLDVQkyfHISDSHAGLLQTVFISCLLVSAPVFGYLGDRYNRKAILSFGILL 124
Cdd:cd17316 176 RRRTLLLILLWFFISFGYYGLTTFLPTYLQTVL---GLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLIL 252

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 125 WSGAGLSSSFISYQYSWLFFLSRGFVGTGAASYSTIAPTVLGDLFVKDQRTCALAVFYIFIPVGSGLGYVLGSTVAELTG 204
Cdd:cd17316 253 SGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTG 332


                ..
gi 58037493 205 NW 206
Cdd:cd17316 333 GT 334
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
39-215 3.67e-05

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 46.02  E-value: 3.67e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493  39 VPWSLPRWRAYLAAAVLCYINLLNYMNWFiiPGVLldvQKYFHISDSHAGLLQTVFISCLLVSAPVFGYLGDRYNRKAIL 118
Cdd:COG2271 175 LLLALLRFWLLALAYFLVYFALYGFLTWL--PTYL---VEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKL 249

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 119 SFGILLWSGAGLSSSFISYQYSWLFFLSRGFVGTGAASYSTIAPTVLGDLFVKDQRTCALAVFYIFIPVGSGLGYVLGST 198
Cdd:COG2271 250 VLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGY 329

                       170
                ....*....|....*..
gi 58037493 199 VAELTGnWRWALRLMPC 215
Cdd:COG2271 330 LLDATG-YQAAFLLLAA 345
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 100-200 6.42e-05

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 45.23  E-value: 6.42e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 100 VSAPVFGYLGDRYNRKAILSFGILLWSGAGLssSFISYQYSWLFFLSRGFVGTGAASYSTIAPTVLGDLFVKDQRTCALA 179
Cdd:cd17370 249 LAAYPAGRLSDRIGRKKLLILGYLSLALAYL--GFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYG 326

                        90       100
                ....*....|....*....|.
gi 58037493 180 VFYIfipvGSGLGYVLGSTVA 200
Cdd:cd17370 327 LFNT----VVGIGWLLASLIA 343
OATP pfam03137
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ...
 76-388 8.29e-05

Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.


Pssm-ID: 460821 [Multi-domain]  Cd Length: 526  Bit Score: 45.27  E-value: 8.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493    76 VQKYFHISDSHAGLLQTVF-ISCLLVSAPVfGYLGDRYNRKAILSFGILLWS-GAGLSSS--FISyqyswlFFLSRGFVG 151
Cdd:pfam03137  27 IEKRFGLPSSLSGLISSSYdIGNLLLIVFV-SYFGGKGHRPRWIGVGALLMGlGSLLFALphFLS------FFLGQLLLG 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493   152 TGAASYSTIAPTVLGDlFVKDQRTCA-LAVFYIFIPVGSGLGYVLGS--------------TVAELTGNWRWA--LRLMP 214
Cdd:pfam03137 100 IGGTPIYTLGISYIDD-NVKKKNSPLyLGILYAVRVLGPALGFLLGSlclriyvdigkvsiTLTPKDPRWVGAwwLGFLI 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493   215 CLDAM----------------ALALLILLVPDVPRGAAEKQGEVAVRAPRSSWCED----VRYLGRNWSFVFSTLGvtAI 274
Cdd:pfam03137 179 AGLLLlltaipffffpkslpgAAKRRAKKKKEPHSQDIADLKKTKSLKKLGPSLKDfpkaLKRLLKNPVYMLLTLA--SV 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493   275 AFVTGALGFWA--PKFLfearvvhglqlpcfQEQCH---SQDSLIFGALTVATGIIGVMLGAEASRRYkKVNPRAEP-LI 348
Cdd:pfam03137 257 FEFLLIAGYATflPKYI--------------ETQFGlsaSTANLLTGVVAIPGAALGILLGGLIIKKF-KLSAKGLAkFN 321

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 58037493   349 CASSLFATAPCLYLALI------LASRTLLASYVFLALGELLLSCN 388
Cdd:pfam03137 322 VITSLVSLLLSLLLFFLgcpnspVAGITVPYGGTQQLSGNLTSSCN 367
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 45-215 9.88e-05

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 44.57  E-value: 9.88e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493  45 RWRAYLAAaVLCYinLLNYMNWFIIPGVLLDVQKYFHISDSHAGLLQTVFISCLLVSAPVFGYLGDRYNRKAILSFGILL 124
Cdd:cd17312   1 RWRIFLGV-FLGY--AAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 125 wsgAGLSSSFISYQYS-WLFFLSRG----FVGTGAASystiAPTVLGDLFVKDQRTCALAVFYIFIPVGSGLGYVLGSTV 199
Cdd:cd17312  78 ---SALANIFMGFSTSlWFFAVLWGlnglFQSMGWPP----CVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASL 150

                       170
                ....*....|....*.
gi 58037493 200 AELTGnWRWALRLMPC 215
Cdd:cd17312 151 ASYYG-WRAAFLVPGI 165
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 45-165 1.58e-04

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 44.14  E-value: 1.58e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493  45 RWRAYLAAAVLCYINLLNYMNWFIIpgvLLDVQKYFHISDSHAGLLQTVFISCLLVSAPVFGYLGDRYN-RKAILSFGIL 123
Cdd:cd17353   1 RRWLVLLGAVLMHLILGYQYAWSVF---NPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGpRKAILIGGIL 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 58037493 124 LWSGAGLSSSFISYQYSWLFFLSRGFVGTGAAsYSTIAPTVL 165
Cdd:cd17353  78 FGLGFILSAFAISLPLLFLGYGVLGGIGAGIG-YITPVSTAV 118
MFS_SLC22A7_OAT2 cd17447
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ...
 89-210 2.01e-04

Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341005 [Multi-domain]  Cd Length: 341  Bit Score: 43.57  E-value: 2.01e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493  89 LLQTVFISCLLVSAPVFGYLGDRYNRKAILSFGILLWSGAGLSSSFiSYQYSwLFFLSRGFVGTGAASYSTIApTVLGDL 168
Cdd:cd17447  39 ATATFFFAGVTMGAVAFGYLSDRFGRKRMLLVAYVLSLVFGLASAF-SVSYV-MFAITRTLTGFALTGFSIIS-MVLCVE 115

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 58037493 169 FVK-DQRTCAlavfYIFIPVGSGLGYVLGSTVAELTGNWRWAL 210
Cdd:cd17447 116 WVDiEHRTVA----GVLISLFWTVGNMLLALVAYLIRDWRWLI 154
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 91-208 3.20e-04

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 43.05  E-value: 3.20e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493  91 QTVFISCLLVSAPVFGYLGDRYNRKAILSFGILLWSGAGLSSSFISYQYSWLFFlsRGFVGTGAASYSTIAPTvlgdLFV 170
Cdd:cd17374  41 QSIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVL--RFLAGFAVSGISINTLI----LGT 114

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 58037493 171 KDQRTCALAVFYIFIPVGSGLGYVLGSTVAELTGNWRW 208
Cdd:cd17374 115 EWTTPRHRALAITLTSCFFSIGQMLLAGLAYAIRDWRL 152
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 81-205 3.29e-04

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 42.93  E-value: 3.29e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493  81 HISDSHAGLLQTVFISCLLVSAPVFGYLGDRYNRKAILSFGILLWSGAGLSSSFISYQYSWLFFLSrGFVGTGAASYSTI 160
Cdd:cd17477 219 GLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLL-FLWGGAAGPLYTL 297

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 58037493 161 APTVLGDLFVKDQRTCALAVFYIFIPVGSGLGYVLGSTVAELTGN 205
Cdd:cd17477 298 ALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGP 342
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
 41-168 3.38e-04

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 42.98  E-value: 3.38e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493  41 WSLPRWRAYLaaaVLCYINLLNYMNWFIIPGVLLDVQKYFHISDSHAGLLQTVFISCLLVSAPVFGYLGDRYNRKAILSF 120
Cdd:cd17332 215 KALLKNRPFL---ILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFFI 291

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 58037493 121 GILLWSGAGLSSSFISYQYSWLFFLSRGFVGTGAASYSTIAPTVLGDL 168
Cdd:cd17332 292 GLLLAILGLLLLFFLPPGNLVLILVLAVLAGIGYGGANLLPWAMLADV 339
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 100-208 3.94e-04

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 42.55  E-value: 3.94e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 100 VSAPVFGYLGDRYNRKAILSFGILLWS----GAGLSSSfisyqySWLFFLSRGFVGTGAASYSTIAPTVLGDLFVKDQRT 175
Cdd:cd17502  45 AFQPIYGKLSDLFGRKWVLLIAIVIFElgslLCGLAPN------MTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERG 118

                        90       100       110
                ....*....|....*....|....*....|...
gi 58037493 176 CALAVFYIFIPVGSGLGYVLGSTVAELTGnWRW 208
Cdd:cd17502 119 KYQGYIGAVFGIASVAGPLIGGAFTDHLS-WRW 150
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 67-210 3.94e-04

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 42.57  E-value: 3.94e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493  67 FIIPGVLLDvqkyFHISDSHAGLLQTVFISCLLVSAPVFGYLGDRYNRKAILSFGILLWSGAGLSSSFIsyQYSWLFFLS 146
Cdd:cd17365  20 FVAPALAQD----WGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFA--QSVLQLALL 93

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 58037493 147 RGFVGTGAASYSTIAPTVLGDLFVKDQRTCALAVFYIFIPVGSGLGYVLGSTVAELTGnWRWAL 210
Cdd:cd17365  94 RFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFG-WRSVF 156
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 79-208 4.93e-04

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 42.29  E-value: 4.93e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493  79 YFHISDSHAGLLQTVFiscLLVSAPV---FGYLGDRYNRKAILSFGILLWSGAGLSSSFIsyQYSWLFFLSRGFVGTGAA 155
Cdd:cd17371  28 EFGLDEAEAGLLGTVT---LAGGAIGgilGGILADRFGRVRVLVITILLFAVFTLLCGFA--QNYWQLLILRALAGLGFG 102

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 58037493 156 SYSTIAPTVLGDLFVKDQRTCALAVFYIFIPVGSGLGYVLGSTVAELTGN---WRW 208
Cdd:cd17371 103 GEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPPeiaWRV 158
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 73-412 5.18e-04

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 42.18  E-value: 5.18e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493  73 LLDVQKYFHISDSHAGLLQTVFISCLLVSAPVFGYLGDRYNRKAILSFGILLWSGAGLSSSFISyQYSWLFFLsRGFVGT 152
Cdd:cd17320  22 LPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALAS-SIEQLLIA-RFLQGL 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 153 GAASYSTIAPTVLGDLFVKDQRTCALAVFYIFIPVGSGLGYVLGSTVAELTGnWR---WALRLMpcldamALALLILLVP 229
Cdd:cd17320 100 GAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFG-WRaifVFLALL------GLLLLLLVLL 172

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 230 DVPrgaaekqgEVAVRAPRSSwceDVRYLGRNWSFVFSTLGVTAIAFVTGAL--GFWApkFLFEARVVHGLQLpcfqeqc 307
Cdd:cd17320 173 FLP--------ETLPEEKRKP---LLSSLLRAYKRVLKNRRFLGYALALGLSfaGLFA--YLAAAPFIYIEQL------- 232

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 308 hSQDSLIFGALTVATgIIGVMLGAEASRRY-KKVNPRAEPLICASSLFATAPCLYLALILASRTLLASYVFLALgeLLLS 386
Cdd:cd17320 233 -GLSPAQFGLLFALN-AIALILGSLLNGRLvRRFGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFL--IFFG 308

                       330       340
                ....*....|....*....|....*..
gi 58037493 387 CNWAV-VADILLSVVVPRCRGTAEALQ 412
Cdd:cd17320 309 FGLIFpNATSLALEPFPHVAGTASALL 335
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 61-209 6.46e-04

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 41.92  E-value: 6.46e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493  61 LNYMNWFII---PGVLL-DVQKYFHISDSHAGLLQTVFISCLLVSAPVFGYLGDRYNRKAILSFGILLWSGAglSSSFIS 136
Cdd:cd17333   3 ISFFSNGLTdalLGILGpSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLA--LALIFA 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 58037493 137 YQYSWLFFLSRGFVGTGAASYSTIAPTVLGDLFVKDQRTcALAVFYIFIPVGSGLGYVLGSTVAELTGNWRWA 209
Cdd:cd17333  81 TPSIYLFVVLMFLAGLGAGILDTGANTFVGALFEESSAT-RLNVLHGFFGLGALIGPLIATSLLTSELSWSWA 152
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 104-209 7.80e-04

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 41.86  E-value: 7.80e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 104 VFGYLGDRYNRKAIL---SFGILLWS-GAGLSSSFISyqyswlFFLSRGFVGTGAASYSTIAPTVLGDLFVK-DQRTCAL 178
Cdd:cd17476  52 IFGRLGDIYGHKKMFvigSFWFAIWSlIAGFSPNFIF------FIICRALQGLGPAFLLPNAMALLGRTYPPgPRKNIVF 125

                        90       100       110
                ....*....|....*....|....*....|.
gi 58037493 179 AVFYIFIPVGSGLGYVLGSTVAELTGnWRWA 209
Cdd:cd17476 126 SLFGATAPLGFALGGVFGGLFAQLAW-WPWI 155
PRK03893 PRK03893
putative sialic acid transporter; Provisional
 35-208 7.95e-04

putative sialic acid transporter; Provisional


Pssm-ID: 179668 [Multi-domain]  Cd Length: 496  Bit Score: 41.99  E-value: 7.95e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493   35 PSTPVPW----SLPRWRAYLAAaVLCYinLLNYMNWFIIPGVLLDVQKYFHISDSHAG-LLQTVFISCLLvSAPVFGYLG 109
Cdd:PRK03893   4 TTQNIPWyrhlNRAQWKAFSAA-WLGY--LLDGFDFVLITLVLTEVQGEFGLTTVQAAsLISAAFISRWF-GGLLLGAMG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493  110 DRYNRKAILSFGILLWSGAGLSSSFiSYQYsWLFFLSRGFVGTG-AASYSTIAPTVLgDLFVKDQRTCALAVFYIFIPVG 188
Cdd:PRK03893  80 DRYGRRLAMVISIVLFSVGTLACGF-APGY-WTLFIARLVIGMGmAGEYGSSATYVI-ESWPKHLRNKASGFLISGFSIG 156

                        170       180
                 ....*....|....*....|
gi 58037493  189 SGLGYVLGSTVAELTGnWRW 208
Cdd:PRK03893 157 AVVAAQVYSLVVPVWG-WRA 175
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 88-204 1.08e-03

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 41.43  E-value: 1.08e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493  88 GLLQTVFiscllvSAPvFGYLGDRYNRKAILSFGILLWSgAGLSSSFISyQYSWLFFLSRGFVGTGAasYSTIAPTVLGD 167
Cdd:cd17472  42 GLTQAIF------QIP-FGLLSDRIGRKPVILFGLLLFI-AGSLLAAYA-TSIYGLILGRALQGSGA--ISSVVMALLAD 110

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 58037493 168 LFVKDQRTCALAVFYIFIPVGSGLGYVLGSTVAELTG 204
Cdd:cd17472 111 LTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLG 147
MFS_SLCO5_OATP5 cd17404
Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of ...
 69-197 1.17e-03

Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 5 (SLCO5) or Organic anion transporting polypeptide 5 (OATP5) family contains only one subfamily, OATP5A, which contains only one mammalian member OATP5A1 (encoded by SLCO5A1). Deletion of the SLCO5A1 gene has been implicated in the pathogenesis of Mesomelia-synostoses syndrome (MSS), a rare autosomal-dominant disorder characterized by mesomelic limb shortening, acral synostoses, and multiple congenital malformations. OATP5A1 may be a non-classical OATP which is involved in biological processes that require the reorganization of the cell shape, such as differentiation and migration. It seems to affect intracellular transport of drugs and may participate in chemoresistance of small cell lung cancer (SCLC by sequestration), rather than mediating cellular uptake. The SLCO5/OATP5 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340962 [Multi-domain]  Cd Length: 425  Bit Score: 41.18  E-value: 1.17e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493  69 IPGVLLDVQKYFHISDSHAGLLQTVF-ISCLLVSapVF-GYLGDRYNRKAILSFGILLwsgAGLSSSFISYQYswLFFLS 146
Cdd:cd17404  22 LNSVITTIEKRYSLKSSESGLIVSSYeIGSLLTV--VFvSYFGGRGHRPRWIAVGGVL---IALGSFLFSLPH--FFILA 94

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 58037493 147 RGFVGTGAASYSTIAPTVLGDLFVKDQRTCALAVFYIFIPVGSGLGYVLGS 197
Cdd:cd17404  95 QILIGMGGTPIFTLGTTYLDDHVKKESSSLYLAIMYVMGALGPAAGFLLGG 145
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
80-482 1.26e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 41.43  E-value: 1.26e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493  80 FHISDSHAGLLQTVFISCLLVSAPVFGYLGDRYNRK-----------AILS--FGILLWSGAGLSSS------FISYqys 140
Cdd:COG2211  41 LGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRwgrrrpwiligAIPLalSFVLLFTAPDLSPTgkliyaLVTY--- 117

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 141 WLFFLSRGFVGTgaaSYSTIAPTVLGDlfvKDQRTCALAVFYIFIPVGSGLGYVLGSTVAELTG-----NWRWALRLMPC 215
Cdd:COG2211 118 LLLGLAYTLVNI---PYSALGAELTPD---YEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGgdaalGYRLTALIFAV 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 216 LDAMALALLILLVPDVPRGAAEKqgevavraprSSWCEDVRYLGRNWSFVFStlgVTAIAFVTGALGFWAPKFLFEARVV 295
Cdd:COG2211 192 LGLLAFLLTFFGTKERPVPEEEK----------VSLKESLKALLKNRPFLLL---LLAYLLFFLALALVAALLLYYFKYV 258

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 296 HGLQlpcfqeqchSQDSLIFGALTVATGIIGVMLGAEASRRYKKVNpraepLICASSLFATAPCLYLALILASRT--LLA 373
Cdd:COG2211 259 LGLS---------AALVGLLLALYFLAALLGAPLWPRLAKRFGKKK-----AFIIGLLLAALGLLLLFFLGPGNLwlLLV 324

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 374 SYVFLALGE-LLLSCNWAVVADIL---LSVVVPRCRGTAEALQiTVAHVLGDAGSPYLTGLISS----VLQAERPDSYLQ 445
Cdd:COG2211 325 LAALAGIGLgAILVLPWAMLADVVdydEWKTGRRREGLYFGIF-TFAIKLGQALAGALAGLLLAlfgyVAGAAQSPSALT 403

                       410       420       430
                ....*....|....*....|....*....|....*..
gi 58037493 446 HFLSLqHSFLCCAFAIVlggGFFLLTALHLEKDQARA 482
Cdd:COG2211 404 GIRLL-FFLLPAVLLLL---AALLLLFYPLTRERHAE 436
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
 89-208 1.28e-03

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 41.18  E-value: 1.28e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493  89 LLQTVFISCLLVSAPVFGYLGDRYNRKAILSFGILLWSGAGLSSSFISYQYSWLFF-LSRGFVGTGA--ASYSTIAPTVl 165
Cdd:cd17379  37 LFQSSLNLGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFrFLQGLFGKGGwmTGYVLVTEFV- 115

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 58037493 166 gdlFVKDQRTCAlavfyIFIPVGSGLGYVLGSTVAELTGNWRW 208
Cdd:cd17379 116 ---GSKYRRTVG-----IVYQMFFTLGLLILPGIAYFIPHWRW 150
MFS_SVOP cd17441
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ...
 89-212 1.40e-03

Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340999 [Multi-domain]  Cd Length: 372  Bit Score: 40.95  E-value: 1.40e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493  89 LLQTVFISCLLVSAPVFGYLGDRYNRKAILSFGILLWSGAGLSSSFiSYQYSWLFFLsRGFVGTGAASYSTiAPTVLGDL 168
Cdd:cd17441  38 LLTSVVFIGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGILSAF-APIYSWILVL-RGLVGFGIGGVPQ-SVTLYAEF 114

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 58037493 169 FVKDQRTCALAVFYIFIPVGSGLGYVLGSTVAELTGnWRWALRL 212
Cdd:cd17441 115 LPMKSRAKCILLIEVFWALGTVFEVLLAVFVMPTLG-WRWLLIL 157
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 66-197 2.07e-03

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 40.28  E-value: 2.07e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493  66 WFIIPGVLLDVQKYFHISDSHAGLLQTVFISCLLVSAPVFGYLGDRYNRKAILsfgILLWSGAGLSSSFISYQYS-WLFF 144
Cdd:cd17331  16 YWLQQPVLPYLTKKLGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAAL---VLSFLSSALSYLLLAFASSvPMLF 92

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 145 LSR-------GFVGtgaasystiAPTVLGDLFVKDQRTCALAvfyiFIPVGSGLGYVLGS 197
Cdd:cd17331  93 LSRlpsvfmhAMQA---------AQMVVTDLTDPGERAAALG----RLGLSYGIGMVVGS 139
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
 78-145 5.02e-03

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 39.10  E-value: 5.02e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 58037493  78 KYFHISDSHAGLLQTVFISCLLVSAPVFGYLGDRYN-RKAILSFGILLWSGAGLSSSFISYQYSWLFFL 145
Cdd:cd17335  25 KQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGkRKALLLLSLLAAVLFFLSLFFVAQIFWLLLLL 93
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
34-213 5.40e-03

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 39.09  E-value: 5.40e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493  34 PPSTPVPWSLPRWRAYLAAAVLCYINLLNY--MNWfiIPGVLLDvqkyFHISDSHAGLLQTVFISCLLVSAPVFGYLGDR 111
Cdd:COG2807 203 PAAASLRSLWRSPLAWLLTLFFGLQSLLYYavVAW--LPPILRD----AGLSAATAGLLLSLFQLAGIPGSLLVPLLADR 276

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 112 YNRKAILSFGILLWSGAGLSssFISYQYSWLFFLSRGFVGTGAASYSTIAPTVLGDLFVKDQRTCAL-----AVFYIfip 186
Cdd:COG2807 277 LGDRRPLLLLLGLLGLAGLL--GLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEAAALsgmaqSVGYL--- 351

                       170       180
                ....*....|....*....|....*..
gi 58037493 187 vGSGLGYVLGSTVAELTGNWRWALRLM 213
Cdd:COG2807 352 -LAALGPLLVGALHDATGSWTAALLLL 377
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 75-210 6.17e-03

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 38.90  E-value: 6.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493    75 DVQKYFHISDSHAGLLQTVFISCLLVSAPVFGYLGDRYNRKAILSFGILLWS----GAGLSSSFisyqysWLFFLSRGFV 150
Cdd:TIGR00881  20 YLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAivnlFFGFSTSL------WVMAALWALN 93

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493   151 GTGAASYSTIAPTVLGDLFVKDQRTCALAVFYIFIPVGSGLGYVLGSTVAELTGNWRWAL 210
Cdd:TIGR00881  94 GIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYSWHWVF 153
TRI12 pfam06609
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ...
 69-208 7.17e-03

Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.


Pssm-ID: 115279 [Multi-domain]  Cd Length: 598  Bit Score: 38.88  E-value: 7.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493    69 IPGVLLDVQKyfhisDSHAGLLQTVFISCLLVSAPVFGYLGDRYNRKA-ILSFGILLWSGAGLSSSFISYQySWLFFLSR 147
Cdd:pfam06609  67 LPNILQDIGQ-----SENQGLFSTLWTMGQAVSILMMGRLTDRFGRRPfVIATHIIGLVGAIVGCTANKFN-TLLAAMTL 140

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 58037493   148 GFVGTGAASYStiaPTVLGDLFVKDQRTCALAVFYIFIPVGSGLGYVLGSTVAeLTGNWRW 208
Cdd:pfam06609 141 LGVAAGPAGAS---PLFIGELMSNKTKFLGLLIVSAPTIAMNGAGPYFGQRLA-IQGNWRW 197
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 47-470 8.76e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 38.37  E-value: 8.76e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493  47 RAYLAAAVLCYINllNYMNWFIIPGVLLDVQKyfhiSDSHAGLLQTVFISCLLVSAPVFGYLGDRYNRKAILSFGILLWS 126
Cdd:cd06173   2 RLLWLAQLLSALG--DWIFTVALPWLVLQLTG----SALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRA 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 127 GAGLSSSFISYQYS---WLFFLSRGFVGTGAASYSTIAPTVLGDLFVKDQRTCALAVFYIFIPVGSGLGYVLGSTVAELT 203
Cdd:cd06173  76 LLAAVLALLALLGSlslWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALL 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 204 GNWrWALrlmpCLDAMALALLILLVPDVPRGAAEKQGEVAVRAPRSSWcEDVRYLGRNWSFVFSTLGVTAIAFVTGALGF 283
Cdd:cd06173 156 GPG-GAF----AINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLR-EGLRYLRRSPLLRLLLLALALFALLGGALTV 229

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 284 WAPKFlfeARVVHGLqlpcfqeqchsqDSLIFGALTVATGiIGVMLGAEASRRYKKVNPRAEPLICASSLFATApclyLA 363
Cdd:cd06173 230 LLPLL---AKEVLGG------------GAAGYGLLLAAFG-VGALLGALLLGRLSKRRRRGRLLLIGALLLGLA----LL 289

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493 364 LILASRTLLASYVFLALGELLLSCNWAVVADILLSVVVPRCRGTAEALQITVAHVLGDAGSPyLTGLISSvlqaerpdsy 443
Cdd:cd06173 290 VLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGAL-LAGLLAD---------- 358

                       410       420
                ....*....|....*....|....*..
gi 58037493 444 lqhFLSLQHSFLCCAFAIVLGGGFFLL 470
Cdd:cd06173 359 ---ALGLSAVFLLAGALLLLAALLLLL 382
MFS_SLC22A6_OAT1_like cd17446
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ...
 89-208 9.14e-03

Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341004 [Multi-domain]  Cd Length: 339  Bit Score: 38.17  E-value: 9.14e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58037493  89 LLQTVFISCLLVSAPVFGYLGDRYNRKAILSFGILLW----SGAGLSSSFISYqYSWLFFLSRGFVGTGAASYSTIA--- 161
Cdd:cd17446  37 LAQSIYMAGVLVGAIVFGGLSDRFGRRPLLIWSYLQMavsgTCAAFSPSFPIY-CVFRFLTGMALSGIVLNSVSLNVewm 115

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 58037493 162 PTvlgdlfvkDQRTCalavfyifipVGSGLGYV------LGSTVAELTGNWRW 208
Cdd:cd17446 116 PT--------RVRAV----------VGTLLGYCytlgqlILAGVAYAIRDWRW 150
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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