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Conserved domains on  [gi|13928740|ref|NP_113734|]
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regucalcin [Rattus norvegicus]

Protein Classification

SMP-30/gluconolactonase/LRE family protein( domain architecture ID 12093833)

SMP-30/gluconolactonase/LRE family protein similar to vertebrate senescence marker protein 30 (SMP-30) and to Pseudomonas putida 6-deoxy-6-sulfogluconolactonase, which catalyzes the hydrolysis of 6-deoxy-6-sulfo-D-glucono-1,5-lactone to form 6-deoxy-6-sulfo-D-gluconate

EC:  3.1.1.99
Gene Ontology:  GO:0046872|GO:0016787
SCOP:  4003251

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
SGL pfam08450
SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in ...
 16-264 1.65e-94

SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.


:

Pssm-ID: 462480 [Multi-domain]  Cd Length: 246  Bit Score: 279.53  E-value: 1.65e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928740    16 CGESPVWEEASKCLLFVDIPSKTVCRWDSISNRVQRVGVDAPVSSVALRQSGGYVATIGTKFCALNWEDQSVFILAMVDE 95
Cdd:pfam08450   1 LGEGPVWDEEEGALYWVDILGGRIHRLDPATGKETVWDTPGPVGAIAPRDDGGLIVALKDGVALLDLATGELTPLADPED 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928740    96 D-KKNNRFNDGKVDPAGRYFAGTMAEETAPAvleRHQGSLYSLFPDHSVKKYFDQVDISNGLDWSLDHKIFYYIDSLSYT 174
Cdd:pfam08450  81 DdWPLNRFNDGKVDPDGRFWFGTMGDDEAPG---GDPGALYRLDPDGKLTRVLDGLTISNGLAWSPDGRTLYFADSPARK 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928740   175 VDAFDYDLPTGQISNRRTVYKMEKDEQIPDGMCIDVEGKLWVACYNGGRVIRLDPEtGKRLQTVKLPVDKTTSCCFGGKD 254
Cdd:pfam08450 158 IWAYDYDLDGGLISNRRVFADFKPGLGRPDGMAVDAEGNVWVARWGGGKVVRFDPD-GKLLREIELPAKRPTSCAFGGPD 236

                         250
                  ....*....|
gi 13928740   255 YSEMYVTCAR 264
Cdd:pfam08450 237 LRTLYVTSAR 246
 
Name Accession Description Interval E-value
SGL pfam08450
SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in ...
 16-264 1.65e-94

SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.


Pssm-ID: 462480 [Multi-domain]  Cd Length: 246  Bit Score: 279.53  E-value: 1.65e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928740    16 CGESPVWEEASKCLLFVDIPSKTVCRWDSISNRVQRVGVDAPVSSVALRQSGGYVATIGTKFCALNWEDQSVFILAMVDE 95
Cdd:pfam08450   1 LGEGPVWDEEEGALYWVDILGGRIHRLDPATGKETVWDTPGPVGAIAPRDDGGLIVALKDGVALLDLATGELTPLADPED 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928740    96 D-KKNNRFNDGKVDPAGRYFAGTMAEETAPAvleRHQGSLYSLFPDHSVKKYFDQVDISNGLDWSLDHKIFYYIDSLSYT 174
Cdd:pfam08450  81 DdWPLNRFNDGKVDPDGRFWFGTMGDDEAPG---GDPGALYRLDPDGKLTRVLDGLTISNGLAWSPDGRTLYFADSPARK 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928740   175 VDAFDYDLPTGQISNRRTVYKMEKDEQIPDGMCIDVEGKLWVACYNGGRVIRLDPEtGKRLQTVKLPVDKTTSCCFGGKD 254
Cdd:pfam08450 158 IWAYDYDLDGGLISNRRVFADFKPGLGRPDGMAVDAEGNVWVARWGGGKVVRFDPD-GKLLREIELPAKRPTSCAFGGPD 236

                         250
                  ....*....|
gi 13928740   255 YSEMYVTCAR 264
Cdd:pfam08450 237 LRTLYVTSAR 246
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 9-291 1.70e-76

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 234.40  E-value: 1.70e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928740   9 VLRENYRCGESPVWEEAsKCLLFVDIPSKTVCRWDSISNRVQRVGVDAP-VSSVALRQSGG-YVATIGTKFCALNWEDQS 86
Cdd:COG3386   2 LADAGFRLGEGPVWDPD-GRLYWVDIPGGRIHRYDPDGGAVEVFAEPSGrPNGLAFDPDGRlLVADHGRGLVRFDPADGE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928740  87 VFILAMvDEDKKNNRFNDGKVDPAGRYFAGTMAEETAPavlerhqGSLYSLFPDHSVKKYFDQVDISNGLDWSLDHKIFY 166
Cdd:COG3386  81 VTVLAD-EYGKPLNRPNDGVVDPDGRLYFTDMGEYLPT-------GALYRVDPDGSLRVLADGLTFPNGIAFSPDGRTLY 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928740 167 YIDSLSYTVDAFDYDlPTGQISNRRTVYKMEKDEQIPDGMCIDVEGKLWVACYNGGRVIRLDPeTGKRLQTVKLPVDKTT 246
Cdd:COG3386 153 VADTGAGRIYRFDLD-ADGTLGNRRVFADLPDGPGGPDGLAVDADGNLWVALWGGGGVVRFDP-DGELLGRIELPERRPT 230

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 13928740 247 SCCFGGKDYSEMYVTCARDGmsaegllrqPDAGNIFKITgLGVKG 291
Cdd:COG3386 231 NVAFGGPDLRTLYVTTARSL---------PLAGALFRVR-VDVPG 265
 
Name Accession Description Interval E-value
SGL pfam08450
SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in ...
 16-264 1.65e-94

SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.


Pssm-ID: 462480 [Multi-domain]  Cd Length: 246  Bit Score: 279.53  E-value: 1.65e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928740    16 CGESPVWEEASKCLLFVDIPSKTVCRWDSISNRVQRVGVDAPVSSVALRQSGGYVATIGTKFCALNWEDQSVFILAMVDE 95
Cdd:pfam08450   1 LGEGPVWDEEEGALYWVDILGGRIHRLDPATGKETVWDTPGPVGAIAPRDDGGLIVALKDGVALLDLATGELTPLADPED 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928740    96 D-KKNNRFNDGKVDPAGRYFAGTMAEETAPAvleRHQGSLYSLFPDHSVKKYFDQVDISNGLDWSLDHKIFYYIDSLSYT 174
Cdd:pfam08450  81 DdWPLNRFNDGKVDPDGRFWFGTMGDDEAPG---GDPGALYRLDPDGKLTRVLDGLTISNGLAWSPDGRTLYFADSPARK 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928740   175 VDAFDYDLPTGQISNRRTVYKMEKDEQIPDGMCIDVEGKLWVACYNGGRVIRLDPEtGKRLQTVKLPVDKTTSCCFGGKD 254
Cdd:pfam08450 158 IWAYDYDLDGGLISNRRVFADFKPGLGRPDGMAVDAEGNVWVARWGGGKVVRFDPD-GKLLREIELPAKRPTSCAFGGPD 236

                         250
                  ....*....|
gi 13928740   255 YSEMYVTCAR 264
Cdd:pfam08450 237 LRTLYVTSAR 246
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 9-291 1.70e-76

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 234.40  E-value: 1.70e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928740   9 VLRENYRCGESPVWEEAsKCLLFVDIPSKTVCRWDSISNRVQRVGVDAP-VSSVALRQSGG-YVATIGTKFCALNWEDQS 86
Cdd:COG3386   2 LADAGFRLGEGPVWDPD-GRLYWVDIPGGRIHRYDPDGGAVEVFAEPSGrPNGLAFDPDGRlLVADHGRGLVRFDPADGE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928740  87 VFILAMvDEDKKNNRFNDGKVDPAGRYFAGTMAEETAPavlerhqGSLYSLFPDHSVKKYFDQVDISNGLDWSLDHKIFY 166
Cdd:COG3386  81 VTVLAD-EYGKPLNRPNDGVVDPDGRLYFTDMGEYLPT-------GALYRVDPDGSLRVLADGLTFPNGIAFSPDGRTLY 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928740 167 YIDSLSYTVDAFDYDlPTGQISNRRTVYKMEKDEQIPDGMCIDVEGKLWVACYNGGRVIRLDPeTGKRLQTVKLPVDKTT 246
Cdd:COG3386 153 VADTGAGRIYRFDLD-ADGTLGNRRVFADLPDGPGGPDGLAVDADGNLWVALWGGGGVVRFDP-DGELLGRIELPERRPT 230

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 13928740 247 SCCFGGKDYSEMYVTCARDGmsaegllrqPDAGNIFKITgLGVKG 291
Cdd:COG3386 231 NVAFGGPDLRTLYVTTARSL---------PLAGALFRVR-VDVPG 265
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
180-241 9.80e-08

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 51.94  E-value: 9.80e-08
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 13928740 180 YDLPTGQIsnrrTVYKMEKDEQIPDGMCIDVEGKLWVACYNGGRVIRLDPETGKrLQTVKLP 241
Cdd:COG4257 128 LDPATGEV----TEFPLPTGGAGPYGIAVDPDGNLWVTDFGANAIGRIDPDTGT-LTEYALP 184
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
180-241 3.67e-07

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 50.40  E-value: 3.67e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 13928740 180 YDLPTGQIsnrrTVYKMEKDEQIPDGMCIDVEGKLWVACYNGGRVIRLDPETGKrLQTVKLP 241
Cdd:COG4257 171 IDPDTGTL----TEYALPTPGAGPRGLAVDPDGNLWVADTGSGRIGRFDPKTGT-VTEYPLP 227
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
107-267 1.81e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 48.15  E-value: 1.81e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928740 107 VDPAGRYFAGTMAEETAPAVLERHQGSLYSLFPDHSVKKYFDQVDISNGLDWSLDHKIFYYIDSLSYTVDAFDydLPTGQ 186
Cdd:COG3391  24 AVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVSVID--LATGK 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928740 187 ISNRRTVYKMekdeqiPDGMCIDVEGK-LWVACYNGGRVIRLDPETGKRLQTVklPVDKTTSCCFGGKDYSEMYVTCARD 265
Cdd:COG3391 102 VVATIPVGGG------PRGLAVDPDGGrLYVADSGNGRVSVIDTATGKVVATI--PVGAGPHGIAVDPDGKRLYVANSGS 173


                ..
gi 13928740 266 GM 267
Cdd:COG3391 174 NT 175
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
180-243 4.75e-06

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 46.94  E-value: 4.75e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 13928740 180 YDLPTGQIsnrrTVYKMEKDEQIPDGMCIDVEGKLWVACYNGGRVIRLDPETGKrLQTVKLPVD 243
Cdd:COG4257  85 IDPKTGEI----TTFALPGGGSNPHGIAFDPDGNLWFTDQGGNRIGRLDPATGE-VTEFPLPTG 143
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
203-241 5.14e-05

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 43.85  E-value: 5.14e-05
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 13928740 203 PDGMCIDVEGKLWVACYNGGRVIRLDPETGKrLQTVKLP 241
Cdd:COG4257  61 PHGIAVDPDGNLWFTDNGNNRIGRIDPKTGE-ITTFALP 98
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
180-241 6.06e-05

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 43.85  E-value: 6.06e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 13928740 180 YDLPTGQIsnrrTVYKMEKDEQIPDGMCIDVEGKLWVACYNGGRVIRLDPETGkrLQTVKLP 241
Cdd:COG4257 214 FDPKTGTV----TEYPLPGGGARPYGVAVDGDGRVWFAESGANRIVRFDPDTE--LTEYVLP 269
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
192-233 7.48e-04

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 40.39  E-value: 7.48e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 13928740 192 TVYKMEKDEQIPDGMCIDVEGKLWVACYNGGRVIRLDPETGK 233
Cdd:COG4257   8 TEYPVPAPGSGPRDVAVDPDGAVWFTDQGGGRIGRLDPATGE 49
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
140-268 1.51e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 39.29  E-value: 1.51e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928740 140 DHSVKKYFDQVDISNGLDWSLDHKIFYYIDSLSYTVDAFDydLPTGQISNRRTVYKMekdeqiPDGMCIDVEGK-LWVAC 218
Cdd:COG3391  99 TGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNGRVSVID--TATGKVVATIPVGAG------PHGIAVDPDGKrLYVAN 170

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 13928740 219 YNGGRVI----RLDPETGKRLQTVklPVDKTTSCCFGGKDYSEMYVTCARDGMS 268
Cdd:COG3391 171 SGSNTVSvivsVIDTATGKVVATI--PVGGGPVGVAVSPDGRRLYVANRGSNTS 222
COG3292 COG3292
Periplasmic ligand-binding sensor domain [Signal transduction mechanisms];
88-233 4.92e-03

Periplasmic ligand-binding sensor domain [Signal transduction mechanisms];


Pssm-ID: 442521 [Multi-domain]  Cd Length: 924  Bit Score: 38.43  E-value: 4.92e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928740  88 FILAMVDEDKKNNRFNDGKVDPAGRYFAGTmaeetapavlerhQGSLYSLFPDHSVKKYFDQVDISNGLDWSL----DHK 163
Cdd:COG3292 112 FTRYPLDPGLPNNSIRSIAEDSDGNIWVGT-------------SNGLYRYDPKTGKFKRFTLDGLPSNTITSLaedaDGN 178

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928740 164 IF----------------YYIDSLSYTVDAFDYDLPTGQISNRrTVYKMekdeqipdgmCIDVEGKLWVACYNGGrVIRL 227
Cdd:COG3292 179 LWvdsdgnlwigtdgnglYRLDPNTGKFEHITHDPDPNSLSSN-SIYSL----------FEDREGNLWVGTYGGG-LNYL 246


                ....*.
gi 13928740 228 DPETGK 233
Cdd:COG3292 247 DPNNSK 252
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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