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Conserved domains on  [gi|13928918|ref|NP_113851|]
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vesicular acetylcholine transporter [Rattus norvegicus]

Protein Classification

vesicular acetylcholine transporter( domain architecture ID 13024370)

vesicular acetylcholine transporter belongs to the major facilitator superfamily (MFS) of transporters and is a glycoprotein involved in acetylcholine transport into synaptic vesicles and is responsible for the accumulation of acetylcholine into pre-synaptic vesicules of cholinergic neurons

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26098515|26758938
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_SLC18A3_VAChT cd17383
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator ...
 36-459 0e+00

Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator Superfamily; Vesicular acetylcholine transporter (VAChT) is also called solute carrier family 18 member 3 (SLC18A3) in vertebrates and uncoordinated protein 17 (unc-17) in Caenorhabditis elegans. It is a glycoprotein involved in acetylcholine transport into synaptic vesicles and is responsible for the accumulation of acetylcholine into pre-synaptic vesicules of cholinergic neurons. Variants in SLC18A3 are associated with congenital myasthenic syndrome in humans. VAChT belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340941 [Multi-domain]  Cd Length: 378  Bit Score: 680.19  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918  36 LVIVCVALLLDNMLYMVIVPIVPDYIahmrggsegptlvsevweptlppptlanasaylantsasptaagsarsilrpry 115
Cdd:cd17383   1 LVIVCIALLLDNMLYMVIVPIIPDYL------------------------------------------------------ 26

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 116 pteSEDVKIGVLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAFADTS 195
Cdd:cd17383  27 ---NEDIAIGVLFASKAIVQLLVNPFSGTLIDRVGYDIPMMIGLTVMFLSTAVFAFGESYAVLFFARSLQGVGSAFADTA 103

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 196 GIAMIADKYPEEPERSRALGVALAFISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLFDALLLLAVAKPFSAAARARAN 275
Cdd:cd17383 104 GLAMIADRFTEEAERSKALGIALAFISFGCLVAPPFGGILYEFAGKEVPFLILAFVCLLDGLLLLLVMKPVRRETRANMP 183

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 276 LPVGTPIHRLMLDPYIAVVAGALTTCNIPLAFLEPTIATWMKHTMAASEWEMGMVWLPAFVPHVLGVYLTVRLAARYPHL 355
Cdd:cd17383 184 EPVGTPIHRLLMDPYIAVCAGALTMANVSLAFLEPTIANWMKDTMNASEWQMGLVWLPAFFPHVLGVYLTVKLAAKYPHY 263

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 356 QWLYGALGLAVIGVSSCVVPACRSFAPLVVSLCGLCFGIALVDTALLPTLAFLVDVRHVSVYGSVYAIADISYSVAYALG 435
Cdd:cd17383 264 QWLMAAVGLAIEGASCFIVPFCTNFGVLIIPLCGICFGIALVDTALLPTLGFLVDVRHVSVYGSVYAIADISYSLAYALG 343

                       410       420
                ....*....|....*....|....
gi 13928918 436 PIVAGHIVHSLGFEQLSLGMGLAN 459
Cdd:cd17383 344 PIVAGQIVHSIGFTQLNIGIGLAN 367
 
Name Accession Description Interval E-value
MFS_SLC18A3_VAChT cd17383
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator ...
 36-459 0e+00

Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator Superfamily; Vesicular acetylcholine transporter (VAChT) is also called solute carrier family 18 member 3 (SLC18A3) in vertebrates and uncoordinated protein 17 (unc-17) in Caenorhabditis elegans. It is a glycoprotein involved in acetylcholine transport into synaptic vesicles and is responsible for the accumulation of acetylcholine into pre-synaptic vesicules of cholinergic neurons. Variants in SLC18A3 are associated with congenital myasthenic syndrome in humans. VAChT belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340941 [Multi-domain]  Cd Length: 378  Bit Score: 680.19  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918  36 LVIVCVALLLDNMLYMVIVPIVPDYIahmrggsegptlvsevweptlppptlanasaylantsasptaagsarsilrpry 115
Cdd:cd17383   1 LVIVCIALLLDNMLYMVIVPIIPDYL------------------------------------------------------ 26

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 116 pteSEDVKIGVLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAFADTS 195
Cdd:cd17383  27 ---NEDIAIGVLFASKAIVQLLVNPFSGTLIDRVGYDIPMMIGLTVMFLSTAVFAFGESYAVLFFARSLQGVGSAFADTA 103

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 196 GIAMIADKYPEEPERSRALGVALAFISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLFDALLLLAVAKPFSAAARARAN 275
Cdd:cd17383 104 GLAMIADRFTEEAERSKALGIALAFISFGCLVAPPFGGILYEFAGKEVPFLILAFVCLLDGLLLLLVMKPVRRETRANMP 183

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 276 LPVGTPIHRLMLDPYIAVVAGALTTCNIPLAFLEPTIATWMKHTMAASEWEMGMVWLPAFVPHVLGVYLTVRLAARYPHL 355
Cdd:cd17383 184 EPVGTPIHRLLMDPYIAVCAGALTMANVSLAFLEPTIANWMKDTMNASEWQMGLVWLPAFFPHVLGVYLTVKLAAKYPHY 263

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 356 QWLYGALGLAVIGVSSCVVPACRSFAPLVVSLCGLCFGIALVDTALLPTLAFLVDVRHVSVYGSVYAIADISYSVAYALG 435
Cdd:cd17383 264 QWLMAAVGLAIEGASCFIVPFCTNFGVLIIPLCGICFGIALVDTALLPTLGFLVDVRHVSVYGSVYAIADISYSLAYALG 343

                       410       420
                ....*....|....*....|....
gi 13928918 436 PIVAGHIVHSLGFEQLSLGMGLAN 459
Cdd:cd17383 344 PIVAGQIVHSIGFTQLNIGIGLAN 367
2_A_01_02 TIGR00880
Multidrug resistance protein;
125-260 2.99e-33

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 123.14  E-value: 2.99e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918   125 GVLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAFADTSGIAMIADKY 204
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 13928918   205 PEEpERSRALGVALAFISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLFDALLLL 260
Cdd:TIGR00880  81 PPE-ERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLA 135
MFS_1 pfam07690
Major Facilitator Superfamily;
124-436 4.12e-27

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 112.13  E-value: 4.12e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918   124 IGVLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAFADTSGIAMIADK 203
Cdd:pfam07690  34 IGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADW 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918   204 YPEEpERSRALGVALAFISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLFDALLLLAVAKPFSA---AARARANLPVGT 280
Cdd:pfam07690 114 FPPE-ERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPESkrpKPAEEARLSLIV 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918   281 PIHRLMLDPYIAVVAGALTTCNIPLAFLepTIATWMKHTMAASEWEMGMVWLPAFVPHVLGVYLTVRLAARYPHLQWLYG 360
Cdd:pfam07690 193 AWKALLRDPVLWLLLALLLFGFAFFGLL--TYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLL 270

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 13928918   361 ALGLAVIGVSSCVVPA---CRSFAPLVVSLCGLCFGIALVdtallPTLAFLVDVRHVSVYGSVYAIADISYSVAYALGP 436
Cdd:pfam07690 271 ALLLLILAALGLLLLSltlSSLWLLLALLLLGFGFGLVFP-----ALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
124-434 1.33e-26

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 110.83  E-value: 1.33e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 124 IGVLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAFADTSGIAMIADK 203
Cdd:COG2814  47 AGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADL 126

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 204 YPEEpERSRALGVALAFISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLFDALLLLAVAKPFSAAARARAnlpvGTPIH 283
Cdd:COG2814 127 VPPE-RRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARL----RGSLR 201

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 284 RLMLDPYIAVVAGALTTCNIPLAFLEPTIATWMKHTMAASEWEMGMVWLPAFVPHVLGVYLTVRLAARYPHLQWLygALG 363
Cdd:COG2814 202 ELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLL--LIG 279

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 13928918 364 LAVIGVSSCVVPACRSFAPLVVSLCGLCFGIALVDTALlptLAFLVDVRHVSVYGSVYAIADISYSVAYAL 434
Cdd:COG2814 280 LLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLL---QALVAELAPPEARGRASGLYNSAFFLGGPL 347
emrD PRK11652
multidrug transporter EmrD;
133-260 9.93e-06

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 47.98  E-value: 9.93e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918  133 ILQLLVNPLSgpfiDRMSYDVPLLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAFADTSGIAMIADKYPEEPERsR 212
Cdd:PRK11652  58 LSQLFYGPLS----DRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLGTGVGGVMARTLPRDLYEGTQLR-H 132

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 13928918  213 ALGVALAFISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLFDALLLL 260
Cdd:PRK11652 133 ANSLLNMGILVSPLLAPLIGGLLTTLFGWRACYLFLLLLGAGVTFSMA 180
 
Name Accession Description Interval E-value
MFS_SLC18A3_VAChT cd17383
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator ...
 36-459 0e+00

Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator Superfamily; Vesicular acetylcholine transporter (VAChT) is also called solute carrier family 18 member 3 (SLC18A3) in vertebrates and uncoordinated protein 17 (unc-17) in Caenorhabditis elegans. It is a glycoprotein involved in acetylcholine transport into synaptic vesicles and is responsible for the accumulation of acetylcholine into pre-synaptic vesicules of cholinergic neurons. Variants in SLC18A3 are associated with congenital myasthenic syndrome in humans. VAChT belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340941 [Multi-domain]  Cd Length: 378  Bit Score: 680.19  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918  36 LVIVCVALLLDNMLYMVIVPIVPDYIahmrggsegptlvsevweptlppptlanasaylantsasptaagsarsilrpry 115
Cdd:cd17383   1 LVIVCIALLLDNMLYMVIVPIIPDYL------------------------------------------------------ 26

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 116 pteSEDVKIGVLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAFADTS 195
Cdd:cd17383  27 ---NEDIAIGVLFASKAIVQLLVNPFSGTLIDRVGYDIPMMIGLTVMFLSTAVFAFGESYAVLFFARSLQGVGSAFADTA 103

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 196 GIAMIADKYPEEPERSRALGVALAFISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLFDALLLLAVAKPFSAAARARAN 275
Cdd:cd17383 104 GLAMIADRFTEEAERSKALGIALAFISFGCLVAPPFGGILYEFAGKEVPFLILAFVCLLDGLLLLLVMKPVRRETRANMP 183

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 276 LPVGTPIHRLMLDPYIAVVAGALTTCNIPLAFLEPTIATWMKHTMAASEWEMGMVWLPAFVPHVLGVYLTVRLAARYPHL 355
Cdd:cd17383 184 EPVGTPIHRLLMDPYIAVCAGALTMANVSLAFLEPTIANWMKDTMNASEWQMGLVWLPAFFPHVLGVYLTVKLAAKYPHY 263

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 356 QWLYGALGLAVIGVSSCVVPACRSFAPLVVSLCGLCFGIALVDTALLPTLAFLVDVRHVSVYGSVYAIADISYSVAYALG 435
Cdd:cd17383 264 QWLMAAVGLAIEGASCFIVPFCTNFGVLIIPLCGICFGIALVDTALLPTLGFLVDVRHVSVYGSVYAIADISYSLAYALG 343

                       410       420
                ....*....|....*....|....
gi 13928918 436 PIVAGHIVHSLGFEQLSLGMGLAN 459
Cdd:cd17383 344 PIVAGQIVHSIGFTQLNIGIGLAN 367
MFS_SLC18A1_2_VAT1_2 cd17384
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ...
 35-459 2.08e-126

Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340942 [Multi-domain]  Cd Length: 373  Bit Score: 374.22  E-value: 2.08e-126
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918  35 VLVIVCVALLLDNMLYMVIVPIVPDYIAhmrggsegptlvsevweptlppptlanasaylantsasptaagsarsilrpr 114
Cdd:cd17384   1 VLVIVYVALLLDNMLLTVVVPIIPDYLN---------------------------------------------------- 28

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 115 yptesEDVKIGVLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAFADT 194
Cdd:cd17384  29 -----ENVRVGLLFASKALVQLITNPIVGPLTNRIGYSLPMFVGFVIMFISTLLFAFGESYGVLFLARALQGVGSACSSV 103

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 195 SGIAMIADKYPEEPERSRALGVALAFISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLFDALLLLAVAKPfsaaARARA 274
Cdd:cd17384 104 AGMGMLASLYPDDKERGKAMGIALGGLALGVLVGPPFGGVMYEFVGKSAPFLILAFLALLDGALQLFILQP----SVKSE 179

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 275 NLPVGTPIHRLMLDPYIAVVAGALTTCNIPLAFLEPTIATWMKHTMAASEWEMGMVWLPAFVPHVLGVYLTVRLAARYPh 354
Cdd:cd17384 180 ESEEGTPWKTLLKDPYILIAAGAICFSNSGIAILEPCLPIWMMETMCPPKWQLGTAFLPDSIGYLIGTNLFGPLAHKIG- 258

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 355 lQWLYGALGLAVIGVSSCVVPACRSFAPLVVSLCGLCFGIALVDTALLPTLAFLVDVRHVSVYGSVYAIADISYSVAYAL 434
Cdd:cd17384 259 -RWLCSLLGMLLVGISLILIPLAKNIYGLIIPHFGLGLGIGMVDSSMMPLLAYLVDLRHSSVYGSVYAIADVAFCLAFAL 337

                       410       420
                ....*....|....*....|....*
gi 13928918 435 GPIVAGHIVHSLGFEQLSLGMGLAN 459
Cdd:cd17384 338 GPSLGGAIVKSIGFPWLMRIIGIIN 362
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 39-457 2.78e-65

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 216.29  E-value: 2.78e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918  39 VCVALLLDNMLYMVIVPIVPDYIAHMrggsegptlvsevweptlppptlanasaylantSASPTAagsarsilrprypte 118
Cdd:cd17325   1 LSLALFLDMLGYGIIIPILPLYAESL---------------------------------GASVAQ--------------- 32

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 119 sedvkIGVLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAFADTSGIA 198
Cdd:cd17325  33 -----IGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMA 107

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 199 MIADKYPEEpERSRALGVALAFISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLFDALLLLAVAKPFSAAARARANL-- 276
Cdd:cd17325 108 LIADIAPPE-ERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAVSaa 186

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 277 PVGTPIHRLMLDPYIAVVAGALTTCNIPLAFLEPTIATWMKHTMAASEWEMGMVWLPAFVPHVLGVYLTVRLAARYPHLQ 356
Cdd:cd17325 187 RLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKP 266

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 357 WLygALGLAVIGVSSCVVPACRSFAPLVVSLCGLCFGIALVDTALLPTLAFLVDVRHvsvYGSVYAIADISYSVAYALGP 436
Cdd:cd17325 267 LI--LIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEG---RGTAMGLFNTAFSLGMVLGP 341

                       410       420
                ....*....|....*....|.
gi 13928918 437 IVAGHIVHSLGFEQLSLGMGL 457
Cdd:cd17325 342 LLGGFLYDAFGFATPFLAAAA 362
2_A_01_02 TIGR00880
Multidrug resistance protein;
125-260 2.99e-33

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 123.14  E-value: 2.99e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918   125 GVLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAFADTSGIAMIADKY 204
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 13928918   205 PEEpERSRALGVALAFISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLFDALLLL 260
Cdd:TIGR00880  81 PPE-ERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLA 135
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 124-442 3.03e-32

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 127.54  E-value: 3.03e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 124 IGVLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAFADTSGIAMIADK 203
Cdd:cd06174  33 LGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADL 112

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 204 YPEEpERSRALGVALAFISFGSLVAPPFGGILYEF--AGKRVPFLVLAAVSLFDALLLLAVAKPFSAAARAR----ANLP 277
Cdd:cd06174 113 FPER-ERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKneeaSSKS 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 278 VGTPIHRLMLDPYIAVVAGALTTCNIPLAFLEPTIATWMKHTMAASEWEMGMVWLPAFVPHVLGVYLTVRLAARY-PHLQ 356
Cdd:cd06174 192 VLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLiGRKP 271

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 357 WLYGALGLAVIGVSSCVVPACRSFAPLVVSLCGLCFGIALVDTALLPTLAFLVDVRhvsvyGSVYAIADISYSVAYALGP 436
Cdd:cd06174 272 LLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIR-----GTAFGLLNTFGFLGGAIGP 346


                ....*.
gi 13928918 437 IVAGHI 442
Cdd:cd06174 347 LLAGFL 352
MFS_1 pfam07690
Major Facilitator Superfamily;
124-436 4.12e-27

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 112.13  E-value: 4.12e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918   124 IGVLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAFADTSGIAMIADK 203
Cdd:pfam07690  34 IGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADW 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918   204 YPEEpERSRALGVALAFISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLFDALLLLAVAKPFSA---AARARANLPVGT 280
Cdd:pfam07690 114 FPPE-ERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPESkrpKPAEEARLSLIV 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918   281 PIHRLMLDPYIAVVAGALTTCNIPLAFLepTIATWMKHTMAASEWEMGMVWLPAFVPHVLGVYLTVRLAARYPHLQWLYG 360
Cdd:pfam07690 193 AWKALLRDPVLWLLLALLLFGFAFFGLL--TYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLL 270

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 13928918   361 ALGLAVIGVSSCVVPA---CRSFAPLVVSLCGLCFGIALVdtallPTLAFLVDVRHVSVYGSVYAIADISYSVAYALGP 436
Cdd:pfam07690 271 ALLLLILAALGLLLLSltlSSLWLLLALLLLGFGFGLVFP-----ALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
124-434 1.33e-26

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 110.83  E-value: 1.33e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 124 IGVLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAFADTSGIAMIADK 203
Cdd:COG2814  47 AGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADL 126

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 204 YPEEpERSRALGVALAFISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLFDALLLLAVAKPFSAAARARAnlpvGTPIH 283
Cdd:COG2814 127 VPPE-RRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARL----RGSLR 201

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 284 RLMLDPYIAVVAGALTTCNIPLAFLEPTIATWMKHTMAASEWEMGMVWLPAFVPHVLGVYLTVRLAARYPHLQWLygALG 363
Cdd:COG2814 202 ELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLL--LIG 279

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 13928918 364 LAVIGVSSCVVPACRSFAPLVVSLCGLCFGIALVDTALlptLAFLVDVRHVSVYGSVYAIADISYSVAYAL 434
Cdd:COG2814 280 LLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLL---QALVAELAPPEARGRASGLYNSAFFLGGPL 347
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 124-457 2.34e-24

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 104.62  E-value: 2.34e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 124 IGVLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAFADTSGIAMIADK 203
Cdd:cd17329  37 VGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADV 116

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 204 YPEEpERSRALGVALAFISFGSLVAPPFGGILYEFaGKRVPFLVLAAVSLFDALLLLAVAKPFSAAARARANLPVGTPIH 283
Cdd:cd17329 117 TTPE-NRTRAFSLLYWAINLGVAIGPLLGGLLLLY-SFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEKTEILRGYK 194

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 284 RLMLDPYIAVVAGALTTCNIPLAFLEPTIATWMKHTMAASEWEMGMVWLPAFVPHVLGVYLTVRLAARYPHLQWLYGALG 363
Cdd:cd17329 195 IVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGIL 274

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 364 LAVIGVSscVVPACRSFAPLVVSLCGLCFGIALVDTALLPTLAFLVDVRHVSVYGSVYAIAdisYSVAYALGPIVAGHIV 443
Cdd:cd17329 275 LFAIGFA--VLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALA---WGLGRAIGPLVGGLLL 349

                       330
                ....*....|....
gi 13928918 444 HSLGFEQLSLGMGL 457
Cdd:cd17329 350 DLLGPGLPWLILAA 363
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
124-448 2.33e-21

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 95.71  E-value: 2.33e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 124 IGVLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAFADTSGIAMIADK 203
Cdd:COG2271  47 LGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEW 126

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 204 YPEEpERSRALGVALAFISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLFDALLllavakpfsaaararanlpvgtpih 283
Cdd:COG2271 127 FPPK-ERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALL------------------------- 180

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 284 rlmldpYIAVVAGALTTCNIPLAFLEPTIATWMKHTMAASEWEMGMVWLPAFVPHVLGVYLTVRLAARYPHLQWLYGALG 363
Cdd:COG2271 181 ------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIG 254

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 364 LAVIGVSSCVVPACRSFAPLVVSLCGLCFGIALVDTALLPTLAFLVDVRHVsvyGSVYAIADISYSVAYALGPIVAGHIV 443
Cdd:COG2271 255 LLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKAR---GTASGLVNTFGFLGGALGPLLVGYLL 331


                ....*
gi 13928918 444 HSLGF 448
Cdd:COG2271 332 DATGY 336
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 140-458 7.08e-20

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 91.46  E-value: 7.08e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 140 PLSGPFIDRMSYDVPLLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAFADTSGIAMIADKYPEEpERSRALGVALA 219
Cdd:cd17324  52 LLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPE-KRGRAIGLVFS 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 220 FISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLFdALLLLAVAKPfSAAARARANLPVGTPIHRLMLDP--YIAVVAGA 297
Cdd:cd17324 131 GLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALL-AALLLWRLLP-SLPPKKPGSLGLLSSLLLLLRNPrlRLAYLITF 208

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 298 LTTCNIPLAFlePTIATWMKHTMAASEWEMGMVWLPAFVPHVLGVYLTVRLAARYPHLQWLYGALGLAVIGVssCVVPAC 377
Cdd:cd17324 209 LLFGGFFALY--TYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALL--LLTLLG 284

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 378 RSFAPLVVSLCGLCFGIALVDTAlLPTLAFLVDVRHVSVYGSVYAIAdisYSVAYALGPIVAGHIVHSLGFEQLSLGMGL 457
Cdd:cd17324 285 PSPLLLLVGLVLWGLGFFAAHSA-LQTRVLRLAPEARGLASSLYLAA---YNLGGALGAALGGLVLDHGGWAGVGWVGAA 360


                .
gi 13928918 458 A 458
Cdd:cd17324 361 L 361
MFS_SLC18B1 cd17385
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ...
 109-457 2.50e-19

Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340943 [Multi-domain]  Cd Length: 390  Bit Score: 89.97  E-value: 2.50e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 109 SILRPRYPTESE-----DVKIGVLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVMFAFAED-------YA 176
Cdd:cd17385  16 SILAPFFPREAEkkgvsDTIIGLVFGCFALVIFLTSPIFGKYLVKIGAKFMFVAGMFVSGGCTILFGFLDRvpdgtvfIA 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 177 TLFAARSLQGLGSAFADTSGIAMIADKYPEEPerSRALGVALAFISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLFDA 256
Cdd:cd17385  96 LCFLVRIVEAVGFAAFITASFAIIAKEFPNNI--ATVLGTLETFSGLGLMLGPPLGGFLYQAGGYELPFLVLGCLLLLTV 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 257 LLLLAVAKPFSAAARARANlpvgtPIHRLMLDPYIAVVAGALTTCNIPLAFLEPTIATWMKhTMAASEWEMGMVWLPAFV 336
Cdd:cd17385 174 PLNMFILPRYDDDPSPKSG-----SMLKLLKIPSVLLLCLSIVSGSVSLGFLDPTLSPHLR-QFKLSPGQVGLMFLILAG 247

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 337 PHVLGVYLTVRLAARYPHLQWLYgALGLAVIGVSSCVV-PA----CRSFAPLVVS---LCGLCFGIALVdtallPTLAFL 408
Cdd:cd17385 248 SYAISAPLWGWLSDKKKIPKWLM-VIGSIITGVGFLLLgPApllpIKSELWMVIIglvLLGLSLGAALV-----PTFPEL 321

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 13928918 409 VDVRH-------VSVYGSVYAIADISYSVAYALGPIVAGHIVHSLGFEQLSLGMGL 457
Cdd:cd17385 322 LNCAReygfpdnLSTYGLVSGLFNAAFSLGAFIGPTLGGFLLERLGFEWAATIQAG 377
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 121-458 8.27e-17

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 82.23  E-value: 8.27e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 121 DVKIGVLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAFADTSGIAMI 200
Cdd:cd17474  33 PAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLI 112

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 201 ADKYpEEPERSRALGVALAFISFGSLVAPPFGGILYEFaGKRVPFLVLAAVSLFDALLLLAVAKPFSAAARARANLPVGT 280
Cdd:cd17474 113 GDLF-EGGERAKAMGLYEAALGLGIAVGPLLGGLLAAI-SWRYPFFLLAALIPVAFLAILFLLPEPKEKAKSSSATKLRD 190

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 281 PIHRLMLDPYIAVVAGALTTCNIPLAFLE--PTIatwMKHTMAASEWEMGMVWLPAFVPHVLGVYLTVRLAARYPHLQWL 358
Cdd:cd17474 191 LKKALRGRGLLTFLVSAFLYFFLYFAFLTylPFL---LELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRI 267

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 359 YgALGLAVIGVSSCVVPACRSFAPLV--VSLCGLCFGIALVDTALLPTLAFLVDVRHV--SVYGSVyaiadisYSVAYAL 434
Cdd:cd17474 268 L-VIGLLLYALSLLLLGFVPSLALLLiaIVLFGLGLGLNLPLLTTLVTELAPEEERGTasSLYNFV-------RFLGQAV 339

                       330       340
                ....*....|....*....|....
gi 13928918 435 GPIVAGHIVHSLGFEQLSLGMGLA 458
Cdd:cd17474 340 GPLLFGLLLEIFGLSAPFLVGAAI 363
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
124-448 8.25e-16

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 79.56  E-value: 8.25e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 124 IGVLFASKAILQLLVNPLSGPFID--------RMSYdvpLLIGLGVMFASTVMFAFAED------YATLFAARSLQGLGS 189
Cdd:COG2211  48 VGLILLVARLWDAITDPLIGALSDrtrtrwgrRRPW---ILIGAIPLALSFVLLFTAPDlsptgkLIYALVTYLLLGLAY 124

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 190 AFADTSGIAMIADKYPEEPERSRALGVALAFISFGSLVAPPFGGILYEFAGK------RVPFLVLAAVSLFDALLLLAVA 263
Cdd:COG2211 125 TLVNIPYSALGAELTPDYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGdaalgyRLTALIFAVLGLLAFLLTFFGT 204

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 264 KPFSAAARARANLPVGtpIHRLMLDPYIAVVAGALTTCNIPLAFLEPTIATWMKHTMAASEWEMGMVWLPAFVPHVLGVY 343
Cdd:COG2211 205 KERPVPEEEKVSLKES--LKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAP 282

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 344 LTVRLAARYPHLQWLYGALGLAVIGVSSCVVPACRSFAPLVVSLCGLCFGIALVDTALLPTLAFLVDVRH----VSVYGS 419
Cdd:COG2211 283 LWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEwktgRRREGL 362

                       330       340
                ....*....|....*....|....*....
gi 13928918 420 VYAIADISYSVAYALGPIVAGHIVHSLGF 448
Cdd:COG2211 363 YFGIFTFAIKLGQALAGALAGLLLALFGY 391
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 155-446 1.51e-15

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 78.37  E-value: 1.51e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 155 LLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAFADTSGIAMIADKYPEEpERSRALGVALAFISFGSLVAPPFGGI 234
Cdd:cd17321  64 FLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGE-RRGRALGLWGAVVGIGAALGPLLGGL 142

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 235 LYEFAGKRVPFLVLAAVslfdALLLLAVAKPFSAAararanlpvgtpihrlmldpyiAVVAGALTTCNIPLAFLeptIAT 314
Cdd:cd17321 143 LLELFGWRWIFLINVPI----GLVALLLARTFSGA----------------------VLAAFLLGAALGGLLFL---LPL 193

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 315 WMKHTMAASEWEMGMVWLPAFVPHVLGVYLTVRLAARYPHLQWLYGALGLAVIGVSS-CVVPACRSFAPLVVSLCGLCFG 393
Cdd:cd17321 194 YLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLlALLGADSSVWLLLPGLVLLGLG 273

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 13928918 394 IALVDTALLPTLAFLVDVRHvsvYGSVYAIADISYSVAYALGPIVAGHIVHSL 446
Cdd:cd17321 274 LGLFATPLTNAALSSVPKEK---AGAASGILNTARQLGGALGVALLGALLTAG 323
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 123-260 5.13e-15

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 76.85  E-value: 5.13e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 123 KIGVLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAFADTSGIAMIAD 202
Cdd:cd17325 236 QIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLAD 315

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 13928918 203 KYPEEpERSRALGVALAFISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLFDALLLL 260
Cdd:cd17325 316 IVPPE-GRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFL 372
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 125-447 5.41e-15

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 76.46  E-value: 5.41e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 125 GVLFASKAILQLLvnplSGPFIDRMSYDVPLLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAFADTSGIAMIADKY 204
Cdd:cd17319  45 SAFFLGYALFQVP----GGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWF 120

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 205 PEEpERSRALGVALAFISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLFDALLLLAVAKPFsaaararanlpvgtpihr 284
Cdd:cd17319 121 PAR-ERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQV------------------ 181

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 285 lmldpyIAVVAGALTTcNIPLAFLEPTIATWMKHTMAASEWEMGMV----WLPAFVPHVLGVYLTVRLA--ARYPHLqwl 358
Cdd:cd17319 182 ------WGLALGYFGI-NYALYGLLTWLPTYLKQARGFSLKQVGLLaaipFLAGAIGMILGGRLSDRLLrgARRLVI--- 251

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 359 ygALGLAVIGVSSCVVPAcrsFAPLVVSLCGLCFGIALVDTALLPTLAFLVDVRHVSVYGSVYAIADISYSVAYALGPIV 438
Cdd:cd17319 252 --IIGLLLAAVGLLLAYL---TTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLL 326


                ....*....
gi 13928918 439 AGHIVHSLG 447
Cdd:cd17319 327 IGYLVDATG 335
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 124-371 2.85e-14

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 73.31  E-value: 2.85e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 124 IGVLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAFADTSGIAMIADK 203
Cdd:COG0477  51 LGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAEL 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 204 YPEEpERSRALGVALAFISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLFdaLLLLAVAKPFSAAARARANLPVGTPIH 283
Cdd:COG0477 131 FPAR-ERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLL--ALVLRLRLPESRGLLLALLALALAALL 207

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 284 RLMLDPYIAVVAGALTTCNIPLAFLEPTIATWMKHTMAASEWEMGMVWLPAFVPHVLGVYLTVRLAARYPHLQWLYGALG 363
Cdd:COG0477 208 LAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLL 287


                ....*...
gi 13928918 364 LAVIGVSS 371
Cdd:COG0477 288 LLLLALLL 295
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 121-458 4.07e-14

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 73.78  E-value: 4.07e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 121 DVKIGVLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAFADTSGIAMI 200
Cdd:cd17489  30 EAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLV 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 201 ADkYPEEPERSRALGVALAFISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLFDALLLLAVAKPFSAAARARanlPVGT 280
Cdd:cd17489 110 AD-IIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAEEA---EAGT 185

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 281 PIHRLMLDPYIAVVAGALTTCNIPLAflepTIATWMKHTMAASEWEMGMVWLPAFVPHVLGV-YLTVRLAARYPHLQWLY 359
Cdd:cd17489 186 RAFRRLVEKKVLPPALILFLASIAYG----AISTFLPLYAAERGISNAGLFFTVYAIALLLSrPFSGKLSDRKGPKTVII 261

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 360 GALGLAVIGVSSCVVPACRSFAPLVVSLCGLCFGialvdtALLPTL-AFLVDVRHVSVYGSVYAIADISYSVAYALGPIV 438
Cdd:cd17489 262 PGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFG------LLFPALqALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLL 335

                       330       340
                ....*....|....*....|
gi 13928918 439 AGHIVHSLGFEQLSLGMGLA 458
Cdd:cd17489 336 LGLVAELFGYRAMFLLAAVV 355
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
124-448 4.92e-14

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 73.73  E-value: 4.92e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 124 IGVLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAFADTSGIAMIADK 203
Cdd:COG0738  45 AGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAAL 124

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 204 YPEepERSRALGVALAFISFGSLVAPPFGGILYEFAGK---RVPFLVLAAVSLFDALLLLAVAKPFSAAARARANlPVGT 280
Cdd:COG0738 125 GPE--TAASRLNLLHAFFSLGALLGPLLGGLLILLGLSlswHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAA-GSAA 201

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 281 PIHRLMLDPYIAVVAGALTTCniplAFLEPTIATW----MKHTMAASEWEMGMVWLPAFVPHVLGVYLTVRLAARYPHLQ 356
Cdd:COG0738 202 SLKSLLKNPRLLLGGLAIFLY----VGAEGAIGDWlplyLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVR 277

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 357 WLYGALGLAVIGVSSCVVPACRSFAPLVVSLCGlcFGIALVDTALLPTLAFLVDVRHVSVYGSVYAIAdisySVAYALGP 436
Cdd:COG0738 278 LLRLSALLAAVGLLLALLAPGPWLALIGLALVG--LGLSLMFPTIFSLALDGLGKRTAAAVSAVLIMG----IVGGAIGP 351

                       330
                ....*....|..
gi 13928918 437 IVAGHIVHSLGF 448
Cdd:COG0738 352 PLIGFLADAFGL 363
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 124-397 7.69e-14

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 72.99  E-value: 7.69e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 124 IGVLFASKAILQLLVNPLSgpfiDRMSYDVPLLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAFADTSGIAMIADK 203
Cdd:cd17320  40 LSAYLLGFALGQLLYGPLS----DRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDL 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 204 YPEEpERSRALGVALAFISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLFdALLLLAVAKPFSAAARARANLPVGTPI- 282
Cdd:cd17320 116 YSGA-ELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLL-LLLLVLLFLPETLPEEKRKPLLSSLLRa 193

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 283 -HRLMLDPYIAVVAGALTTCNIPLAFLEPTIATWMKHTMAASEWEMGMVWLPAFVPHVLGVYLTVRLAARYPHLQWLYGA 361
Cdd:cd17320 194 yKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLG 273

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 13928918 362 LGLAVIGVSSCVVPAC---RSFAPLVVSLCGLCFGIALV 397
Cdd:cd17320 274 LLLLLAAALVLLLAALlggLSLWPLVAPLFLIFFGFGLI 312
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
124-447 1.52e-13

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 72.22  E-value: 1.52e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 124 IGVLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAFADTSGIAMIADK 203
Cdd:COG2223  42 LGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKW 121

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 204 YPEEpERSRALGVALAFISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLFDALLLLAVAKPFSAAARARANLPVGTPIH 283
Cdd:COG2223 122 FPPD-RRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLE 200

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 284 rLMLDP---YIAVVAGALTTCNIPLAFLEPTIA-TWMKHTMAASEWEMGMVWLPAFVPHVLGVYLTVRLAARYPHLqWLY 359
Cdd:COG2223 201 -ALRDPrfwLLSLLYFGTFGSFIGFSSWLPPYLvDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLL-IVF 278

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 360 GALGLAVIGVSScvvpACRSFAPLVVSLCGLCFGIALVDTALLPTLAFLVDVRHVsvyGSVYAIADISYSVAYALGPIVA 439
Cdd:COG2223 279 ALMALGLLLLAL----ALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNA---GAVYGLVGAAGGLGGFLGPLLF 351


                ....*...
gi 13928918 440 GHIVHSLG 447
Cdd:COG2223 352 GALLDATG 359
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 140-447 2.73e-13

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 71.45  E-value: 2.73e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 140 PLSGPFIDRMSYDVPLLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAFADTSGIAMIADKYpEEPERSRALGVALA 219
Cdd:cd17473  53 PLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYF-EGEERAKMLGLQSA 131

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 220 FISFGSLVAPPFGGILYEFaGKRVPFLV--LAAVSLFDALLLLAVAKPFSAAARARANLPVGTPIHRLMLDPYIAVVAGA 297
Cdd:cd17473 132 AMSLGGVVFLLLGGALAEI-GWRAPFLVylLALPVLILVLLFLPEPARKSKSAASPGAATAAALPWKRVLPIYFLAFLAM 210

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 298 LttcnipLAFLEPT-IATWMKHTMAASEWEMGMVWLPAFVPHVLGVYLTVRLAARYPHLQWLYGALGLAVIGVSSCvvpA 376
Cdd:cd17473 211 L------LFYVIPIqLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLL---A 281

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 13928918 377 CRSFAPLVVsLCGLCFGIALvdTALLPTL-AFLVDVRHVSVYGSVYAIADISYSVAYALGPIVAGHIVHSLG 447
Cdd:cd17473 282 LASGLWVVL-LGAILAGLGF--GLLLPTLnSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTG 350
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
124-458 4.66e-13

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 70.67  E-value: 4.66e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 124 IGVLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAFADTSGIAMIADK 203
Cdd:COG2807  55 AGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRW 134

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 204 YPEepERSRALGVALAFISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLFDALLLLAVAKpfsAAARARANLPVGTPIH 283
Cdd:COG2807 135 FPD--RVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLR---RRPAAAAAAPAAASLR 209

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 284 RLMLDPYIAVVAGALTTCN----IPLAFLePTIATWMKHTMAASEWEMGMVWLPAFVPHVLGVYLTVRLAARYPhlqWLY 359
Cdd:COG2807 210 SLWRSPLAWLLTLFFGLQSllyyAVVAWL-PPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRP---LLL 285

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 360 GALGLAVIGVSSCVVpACRSFAPLVVSLCGLCFGIALVDTALLPTLAFlvdvRHVSVYGSVYAIADISYSVAYALGPIVA 439
Cdd:COG2807 286 LLGLLGLAGLLGLLL-APGSLPWLWAVLLGLGQGGLFPLALTLIGLRA----RTPAEAAALSGMAQSVGYLLAALGPLLV 360

                       330
                ....*....|....*....
gi 13928918 440 GHIVHSLGFEQLSLGMGLA 458
Cdd:COG2807 361 GALHDATGSWTAALLLLAA 379
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 137-447 1.09e-11

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 66.53  E-value: 1.09e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 137 LVNPLSGPFIDRMSYDVPLLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAFADTSGIAMIADKYPEEPERSRALGV 216
Cdd:cd17355  53 LAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGI 132

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 217 ALAFISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLFDA--LLLLAVAKPFSAAARARANLPVGTPIH---RLMLDPYI 291
Cdd:cd17355 133 LTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLvpVLLLLRRRPADLALRAYDDASPASPGStlkEALRSASF 212

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 292 AVVAGALTTCNIPLAFLEPTIATWMKH---TMAASEWEMGMVWLPAFVPHVLGVYLTVRLAARYPhLQWLYGALGLAVIG 368
Cdd:cd17355 213 WLLALAFFLCGFAVVGLIVHLVPYLADrgiSPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRL-LAASYALRALGLAL 291

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 369 VSSCvvpacrSFAPLVVSLCGLCFGiaLVDTALLPTLAFLVDVRH-VSVYGSVYAIADISYSVAYALGPIVAGHIVHSLG 447
Cdd:cd17355 292 LLLL------PFPPLALLLFAALFG--LGWGATVPLTAALAARYFgARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTG 363
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 124-267 2.87e-11

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 64.91  E-value: 2.87e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 124 IGVLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAFADTSgIAMIADK 203
Cdd:cd17330  36 VGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVSVA-QAYIADI 114

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 13928918 204 YPEEpERSRALGVALAFISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLFDALLLLAVAKPFS 267
Cdd:cd17330 115 TDEE-ERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFLPPLR 177
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 134-440 3.43e-11

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 64.88  E-value: 3.43e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 134 LQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVMFAFAEDYATLFAARS-LQGLGSAFADTSGIAMIA---DKYpeepe 209
Cdd:cd17352  50 VSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLYLTYGvLGGLGLGLIYSPAIVIVGqyfEKK----- 124

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 210 RSRALGVALAFISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLfdallllavakpfsaaararaNLPVGTPIHRLMLDP 289
Cdd:cd17352 125 RGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLILGGLCL---------------------NLCVCGLLLRLLKDP 183

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 290 -YIAVVAGALTT---CNIPLAFLePTIATWMKHTMAASEWEMGMVwlpAFVpHVLGVYLTVRLAARYPHLQWLYGALGLA 365
Cdd:cd17352 184 tFVLLALGVSFAmlgFFVPFVYL-PSYAKSLGIDESDAAFLLSII---GIS-DIVGRILLGLLADKPRIGRLYLYIFTLL 258

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 13928918 366 VIGVSSCVVPACRSFAPLVV--SLCGLCFGIALVDTALlpTLAFLVDVRHVSV-YGSVYAIAdisySVAYALGPIVAG 440
Cdd:cd17352 259 ILGLSLLAFPLATTYVGLIVfsVLFGFCSGSYSSLTPV--ILADLVGLEKLSNaYGLVLLFQ----GLAALVGPPIAG 330
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 124-459 2.19e-10

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 62.63  E-value: 2.19e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 124 IGVLFASKAILQLLVNPLSGPFIDRMS-----YDVPLLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAFADTSGIA 198
Cdd:cd06173  36 VGLVLAAFFLPFLLFSPFAGVLADRFDrrrllILADLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQA 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 199 MIADKYPEEpERSRALGVALAFISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLFDALLLLAVAKPFSAAARARANLPV 278
Cdd:cd06173 116 LLPELVPKE-QLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLL 194

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 279 GTP---IHRLMLDPYIAVVAGALTTCNIPLAFLEPTIATWMKHTMAASEWEMGMVWLPAFVPHVLGVYLTVRLAARYPHL 355
Cdd:cd06173 195 RDLregLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRG 274

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 356 QWLygALGLAVIGVSSCVVPACRSFAPLVVSLCGLCFGIALVDTALLPTLAFLVDVRhvsVYGSVYAIADISYSVAYALG 435
Cdd:cd06173 275 RLL--LIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDE---LRGRVFSVYNALNSGAMPLG 349

                       330       340
                ....*....|....*....|....
gi 13928918 436 PIVAGHIVHSLGFEQLSLGMGLAN 459
Cdd:cd06173 350 ALLAGLLADALGLSAVFLLAGALL 373
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 124-442 6.96e-10

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 60.70  E-value: 6.96e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 124 IGVLFASKAILQLLVN-PLsGPFIDRMSYDVPLL-IGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAFAdTSGIAMIA 201
Cdd:cd17490  33 IGIILGAYGISQMLLRiPL-GILSDRIGKRKLFIiIGLLFTVLASLIMILFPSPWGLLIARFLSGIAAATW-VSFTVLYA 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 202 DKYPEEpERSRALGVALAFISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLFDALLLLAVAKPFSAAARAranLPVGTP 281
Cdd:cd17490 111 SYFPPD-EAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEERREKKPV---LTELKE 186

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 282 IHRLMLDPYIAVVAG-ALTTCNIPLAF---LEPTIAtwmkHTMAASEWEMGMVWLPAFVPHVLGVYLTVRLAARYPHLQW 357
Cdd:cd17490 187 LLSVLKDKKLLFFSLlAILQQMITFSTtfgFTPLIA----KQLGASSFQLGLLSIIYLLPNALASLLSGTLFYKKLGERN 262

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 358 LYgALGLAVIGVSSCVVPacrsFAP------LVVSLCGLCFGIalvdtaLLPTLAFLVdVRHVS---------VYGSVYA 422
Cdd:cd17490 263 TI-IIGFLLLGAYCFLIP----FAPnltllyLLQALNGFGTGI------LFPLLMSLS-IEGVPaeqrstamgFFQAIYA 330

                       330       340
                ....*....|....*....|
gi 13928918 423 IADIsysvayaLGPIVAGHI 442
Cdd:cd17490 331 LGMF-------LGPVLVGII 343
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 124-454 1.63e-09

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 59.54  E-value: 1.63e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 124 IGVLFASKAILQLlvnPLsGPFIDRMSYDVPLLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGsAFAdTSGIAMIADK 203
Cdd:cd17472  38 LGIYGLTQAIFQI---PF-GLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSG-AIS-SVVMALLADL 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 204 YPEEpERSRALGVALAFISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLFDALLLLAVAKPFSAAARARANLPVGTPI- 282
Cdd:cd17472 112 TREE-NRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDPPKIVQISEKEKKKLKKl 190

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 283 ---HRLMLDPYIAVVAGALTTCN---IPLAFLEPTIatwmkhtmaaSEWEMGMVWLPAFVPHVLGVYLTVRLAARYpHLQ 356
Cdd:cd17472 191 lknKRLLRLDFSIFILHFVLMAFfyiLPLLLTQLGG----------GKGQLWKVYLPAILIGFILMVPFVIYAEKK-GKM 259

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 357 WLYGALGLAVIGVS-SCVVPACRSFAPLVVSLCGLCFGIALVDTALLPTLAFLVDVRHvsvYGSVYAIADISYSVAYALG 435
Cdd:cd17472 260 KQVFVSSILLIAVGfLLLLFAATSLWLLIIGLIIFFIGFNLLEALLPSLVSKIAPKEY---RGTAMGIYNTSQFLGSFLG 336

                       330
                ....*....|....*....
gi 13928918 436 PIVAGHIVHSLGFEQLSLG 454
Cdd:cd17472 337 GALGGLLWGLLGYSSVFLT 355
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 124-260 2.23e-09

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 59.13  E-value: 2.23e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 124 IGVLFASKAILQLLVNPLSGPFIDRMSYdvplLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAFADTSGIAMIADK 203
Cdd:cd17323  40 VSLFVLGFGLGPLIWAPLSELYGRRPVY----LVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADL 115

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 13928918 204 YPEEpERSRALGVALAFISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLFDALLLL 260
Cdd:cd17323 116 FTPE-ERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLILIF 171
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 122-260 9.58e-09

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 57.20  E-value: 9.58e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 122 VKIGVLFASKAILQLLVN-PLSGPFIDRMSYDVPLLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAFADTSGIAMI 200
Cdd:cd17330 210 SQIGLLLALVGIAGILAQlLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALL 289

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 201 AdKYPEEPERSRALGVALAFISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLFDALLLL 260
Cdd:cd17330 290 S-KSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLS 348
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 132-273 2.93e-08

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 55.85  E-value: 2.93e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918   132 AILQLLVNPLSgpfiDRMSYDVPLLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAFADTSGIAMIADKYPEEpERS 211
Cdd:TIGR00710  54 AAGQLLWGPLS----DRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGE-ELS 128

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 13928918   212 RALGVALAFISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLFdALLLLAVAKPFSAAARAR 273
Cdd:TIGR00710 129 RIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGIL-LSALIFFILPETLPYEAR 189
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 125-440 2.94e-08

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 56.09  E-value: 2.94e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 125 GVLFASKAILQLLVNPLSGPFIDRmsYDVPLLIGLGVMFASTVMFA--FAEDYATLFAARSLQGLGSAFADTSGIAMIAD 202
Cdd:cd17328  37 GLLQTVFIISYMVLSPIFGYLGDR--YNRKWILAVGILIWSAATLLssFAPNFWQLLLFRALVGIGEASYSPIAPTIIAD 114

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 203 KYPEEpERSRALGVALAFISFGSLVAPPFGGILYEFAGK-RVPFLVLAAVSLFDALLLLAVAK--PFSAAARARANLPVG 279
Cdd:cd17328 115 LFPKE-KRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGwRWAFRVTGVLGVLLAILLLLFVRepPRGAAEGGVMAKSTA 193

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 280 TPIHRLMLD-----PYIAVVAGAlTTCNIPLAFLEPTIATWMKHTMAASEWEMGMVWL--------PAFVPHVLGVYLTV 346
Cdd:cd17328 194 TSFLADLKAlaknpSFILSTLGF-TAVSFVTGALAFWAPTFFLRAFGVGDLSSADVGLifgaitciAGVLGVLLGGILAD 272

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 347 RLAARYPHLQWLYGALGLAVIGVSSCVVPACRSFAPLVVSLCGLcFGIALVDTALLPTLAFLVDVRHVSVYGSVYAIAD- 425
Cdd:cd17328 273 RLRRKTPRADPLVCAVGLLAAAPFLFLALVLALSNLLLAWVLLF-LGEFLLSLNWAPVFAILLYVVIPTRRSTASAIQIl 351

                       330
                ....*....|....*
gi 13928918 426 ISYSVAYALGPIVAG 440
Cdd:cd17328 352 LSHLLGDAGSPYLIG 366
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
122-265 7.73e-08

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 54.49  E-value: 7.73e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 122 VKIGVLFASKAILQLLVNPLSGPFIDRM--SYDVPLLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAFADTSGIAM 199
Cdd:COG2271 216 AQAGLLLSLPFLAGIVGSLLGGWLSDRLgrRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWAL 295

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 13928918 200 IADKYPEEpERSRALGVALAFISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLFDALLLLAVAKP 265
Cdd:COG2271 296 AAELFPKK-ARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRE 360
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 132-448 8.82e-08

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 54.15  E-value: 8.82e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 132 AILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVMFAFAEDYATLFAARslqgLGSAFADT-SGIAMIADKYPEEPER 210
Cdd:cd17331  45 SVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFLSR----LPSVFMHAmQAAQMVVTDLTDPGER 120

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 211 SRALG-VALAFiSFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLFDALLLLA-VAKPFSAAARARANLPVGTP------- 281
Cdd:cd17331 121 AAALGrLGLSY-GIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIVLVILlIPSNTKSKREKEAKESASPPsvfnlke 199

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 282 IHRLMLDPYIAVVAGALTTCNIPLAFLEPTIATWMKHTMAASEWEMGMVWLPAFVPH-VLGVYLTVRLAARYPHLQWLYG 360
Cdd:cd17331 200 ILRLLRLPGVAFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENGYLMSYAGVLGmVVQGLLVGPLTKRFGERSLLKL 279

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 361 ALGLAVIGVssCVVPACRSFAPLVVSLCGLCFGIALVDTALLPTLAFLVDvrhVSVYGSVYAIADISYSVAYALGPIVAG 440
Cdd:cd17331 280 SVALLAIGY--LLLAFVTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVP---PEDTGTALGLSHALFSLVRTVSPTIGG 354


                ....*...
gi 13928918 441 HIVHSLGF 448
Cdd:cd17331 355 ALLQAYGF 362
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 124-444 1.08e-07

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 53.86  E-value: 1.08e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 124 IGVLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAFADTSGIAMIADK 203
Cdd:cd17333  33 VSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILDTGANTFVGAL 112

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 204 YPEEPerSRALGVALAFISFGSLVAPPFGG-ILYEFAGKRVPFLVLAAVSLfdALLLLAVAKPFSAAARARANLPVGTPI 282
Cdd:cd17333 113 FEESS--ATRLNVLHGFFGLGALIGPLIATsLLTSELSWSWAYLIIGLIYL--LLAILILLTLFPELPSARNPQQSVGAF 188

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 283 HRLMLDPY--IAVVAGALttcnipLAFL----EPTIATWMKhTMAASEWEMGMV---------WLPAFVPHVLGVYLTVR 347
Cdd:cd17333 189 SASASRLLrnPSIILGAL------ALFLyvgaETAFSSWVP-SYLVEKKHVSDGlagyllsgfWVGITIGRLLGGPISRR 261

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 348 LAaryPHLQWLYGALGLAVIGVSSCVVPacrSFAPLVVSLCGLCFGIALVDTALLPTLAFLVDVRHVSVYGSVYAIAdis 427
Cdd:cd17333 262 IK---PHTLLVLSGSGALLGLLILLLAP---TLVVGLVATALLGLFMAALFPTILSLGISNLPYAKGKGTSVLLAAG--- 332

                       330
                ....*....|....*..
gi 13928918 428 ySVAYALGPIVAGHIVH 444
Cdd:cd17333 333 -SIGGAIIPFIMGFIAE 348
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 140-259 1.51e-07

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 53.73  E-value: 1.51e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 140 PLSGPFIDRMSYDVPLLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAFADTSGIAMIADKYPEEpERSRALGVALA 219
Cdd:cd17503  49 PLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPE-KRGAAMGLVGL 127

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 13928918 220 FISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLFDALLL 259
Cdd:cd17503 128 VILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLLA 167
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 124-260 3.56e-07

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 52.55  E-value: 3.56e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 124 IGVLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAFADTSGIAMIADK 203
Cdd:cd17370 236 IPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADL 315

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 13928918 204 YPEEpERSRALGVALAFISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLFDALLLL 260
Cdd:cd17370 316 VPAE-LRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 124-259 3.88e-07

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 52.23  E-value: 3.88e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 124 IGVLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVMFAFAEDYATLFAARSLQGLgsaFADTSGI--AMIA 201
Cdd:cd17390  33 IGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGI---FKHTQSLckAYLS 109

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 13928918 202 DKYPEEpERSRALGVALAFISFGSLVAPPFGGILYEFA-GKRVPFLVLAAVSLFDALLL 259
Cdd:cd17390 110 DLVSEQ-ERSRVLGRFNAASSLGFILGPVVGGHLAETDgGFYYVALLCSAIFILNAGLV 167
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 124-295 1.60e-06

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 50.25  E-value: 1.60e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 124 IGVLFASKAILQLLVNPLSGPFIDRMSYdvPLLIGLGVMFASTVM--FAFAEDYATLFAARSLQGLGSAFADTSGIAMIA 201
Cdd:cd17478  33 AGLLVSVFSITSSLLQPLFGYLADRKPR--RYLLPLGPLLTGLGLslLGFAPNYWLLLLLVALAGIGSAAFHPEGARLAS 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 202 DKYPEeperSRALGVALaFISFGSL---VAPPFGGILYEFAGKRVPFLVLAAVSLFDALLLLAVAKPFSAAARARANLPV 278
Cdd:cd17478 111 QAAGG----RRGLAMSI-FSVGGNLgfaLGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEAKKAAAKSS 185

                       170
                ....*....|....*..
gi 13928918 279 GTPIHRLMLDPYIAVVA 295
Cdd:cd17478 186 ARSTLKGVWRALLLLLI 202
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 124-258 3.52e-06

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 49.17  E-value: 3.52e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 124 IGVLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVMFAFAEDYATLFAARSLQGL-GSAFADTSgiAMIAD 202
Cdd:cd17388  40 YGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRIIAGItGATGAVAA--AYIAD 117

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 13928918 203 KYPEEpERSRALGVALAFISFGSLVAPPFGGILYEFaGKRVPFLVLAAVSLFDALL 258
Cdd:cd17388 118 VTPPE-QRARNFGLLGAAFGLGFIAGPALGGLLGEI-SPRAPFLVAAGLNGLNFLL 171
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 155-442 4.86e-06

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 48.73  E-value: 4.86e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 155 LLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAfADTSGIAMIADKYPEEpERSRALGVALAFISFGSLVAPPFGGI 234
Cdd:cd17504  64 LLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGGA-VFPLAFALVREEFPPE-RVPVAQGILSATFGIGAGIGLPLGGW 141

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 235 LYEFAGKRVPFLVLAAVSlfdalLLLAVAKPFsaaararanLPVGTPIHRLMLDPYIAVVAGALTTCN----IPLAFLEP 310
Cdd:cd17504 142 IVQHLGWRWIFWTAAPVA-----VLLAALVPL---------IDLRLLRRRNVLLANITALLAGFGMFMvfqlLPQLLQLP 207

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 311 TIATWMkhtmaASEWEMGMVWLPAFVPHVLGVYLTVRLAARYPHLQWLYGALGLAVIG-VSSCVVPAcrSFAPLVVSLCG 389
Cdd:cd17504 208 TPTGFG-----LGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGlLLLALLHS--SLWALVVALLL 280

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 13928918 390 LCFGIALVDTALLPTLAFLVDVRHVSVYGSVYAIAdisYSVAYALGPIVAGHI 442
Cdd:cd17504 281 IGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVL---RTIGSAIGPAIAGAI 330
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 141-268 6.37e-06

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 48.32  E-value: 6.37e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 141 LSGPFIDRMSYDVPLLIGLGVMFASTVMFAFAEDYAT--LFAARSLQGLGSAFADTSGIAMIADKYPEEpERSRALGVAL 218
Cdd:cd17380  53 LGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSLplLILSRILLGLGEGVHFPSMTSLFSRWVPVS-ERSRAVSIVT 131

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 13928918 219 AFISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLFDALLLLAVAKPFSA 268
Cdd:cd17380 132 AGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWALVWLIYLPPVWA 181
emrD PRK11652
multidrug transporter EmrD;
133-260 9.93e-06

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 47.98  E-value: 9.93e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918  133 ILQLLVNPLSgpfiDRMSYDVPLLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAFADTSGIAMIADKYPEEPERsR 212
Cdd:PRK11652  58 LSQLFYGPLS----DRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLGTGVGGVMARTLPRDLYEGTQLR-H 132

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 13928918  213 ALGVALAFISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLFDALLLL 260
Cdd:PRK11652 133 ANSLLNMGILVSPLLAPLIGGLLTTLFGWRACYLFLLLLGAGVTFSMA 180
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 140-416 1.06e-05

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 47.56  E-value: 1.06e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 140 PLSGPFIDRMSYDVPLLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAFADTSGIAMIADKYPEEpERSRALGVALA 219
Cdd:cd17502  48 PIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPR-ERGKYQGYIGA 126

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 220 FISFGSLVAPPFGGILYEFAGKRVPFLVlaavslfdallllavakpfsaaararaNLPVGTPIhrLMLDPYIAVVAGALT 299
Cdd:cd17502 127 VFGIASVAGPLIGGAFTDHLSWRWCFYI---------------------------NLPIGGLA--LALLRTILLSSIFGF 177

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 300 TCNIPLAFLEPTIATWMKHTMAASEWEMGMVWLPAFVPHVLGVYLTVRLAARYPHL-QWLYGALGLAVIG-VSSCVVPAC 377
Cdd:cd17502 178 LFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGRYkPLIVIGTILMSVGaGLLTTLTLD 257

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 13928918 378 RSFAPLVVSLCGLCFGIALVDTALLPTLAFLVDVRHVSV 416
Cdd:cd17502 258 TSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGV 296
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 134-447 1.21e-05

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 47.54  E-value: 1.21e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 134 LQLLVNPLSGPFIDRM-SYDVPLLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAFADTSGIAMIADKYPEEpERSR 212
Cdd:cd17370  46 LGSLLRLFSGYLSDRTgKRKPLVILGYGLSALAKPLLALAGSWQLVLLLRILERLGKGIRTPPRDALLADATPPS-GRGK 124

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 213 ALGVALAFISFGSLVAPPFGGILYEFAGK--RVPFLVLAAVSLFdALLLLAVAKPFSAAARARANLPVGTPIHRLMLDPY 290
Cdd:cd17370 125 AFGLHRALDTLGAVLGPLLAALLLYLLGGnyRTIFLLAAIPALL-ALLILLFVVKEYPRPPKLRKKSKKTSLKKLPKAFW 203

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 291 IAVVAGAL-TTCNIPLAFLeptiaTWMKHTMAASEWEMGMVWLPAFVPHVLGVYLTVRLAARYPHLQWLYGALGLAVIGV 369
Cdd:cd17370 204 LYLLAVALfALGNFSFAFL-----ILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAY 278

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 13928918 370 SSCVVPACRSFAPLVVSLCGLcfGIALVDTALLPTLAFLVDVRHvsvYGSVYAIADISYSVAYALGPIVAGHIVHSLG 447
Cdd:cd17370 279 LGFALGSSLWLLLLGFILWGL--YMGAQESIERAAVADLVPAEL---RGTAYGLFNTVVGIGWLLASLIAGYLWDLIS 351
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 125-448 1.33e-05

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 47.64  E-value: 1.33e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 125 GVLFASKAILQLLVNPLSGPFIDRMSYDVPLL-IGLGVMFASTVMfAFAEDYATLFAARSLQGLGSAFADTSgIAMIADK 203
Cdd:cd17391  39 GLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLrASLGMAIVIGLM-AFVTNVWQLLILRLLQGVFSGYVPNA-TALIASQ 116

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 204 YPEEpERSRALGVALAFISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLFDALL-LLAVAKPFSAAARARANLpvGTPI 282
Cdd:cd17391 117 TPKE-KSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLLFLAFLLtLFFVKEDFKPVEKKKMVS--TKEV 193

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 283 HRLMLDPYIaVVAGALTTCNIPLAF--LEPTIATWMKHTMAASEWEM---GMVW-LPAFVPHVLGVYLTvRLAARYPHLQ 356
Cdd:cd17391 194 WNSVPNPSL-LISLFVTTFIIQLANqsIEPILTLYIRQLMGDASNLAfisGLVFsATGVSSLLSAPRLG-KLGDRIGHHR 271

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 357 WLYGALGLAVIGVSSCvvpacrSFAPLVVSLCGLCFGIALVDTALLPTL-AFLVDVRHVSVYGSVYAIADISYSVAYALG 435
Cdd:cd17391 272 ILLGALLASALLYIPQ------AFVQTPWQLGILRFLLGLATGGLLPAInSLLAKITPKEVAGRIFGYNQSFQYLGNVAG 345

                       330
                ....*....|...
gi 13928918 436 PIVAGHIVHSLGF 448
Cdd:cd17391 346 PLLGSAIAAHFGY 358
PRK11043 PRK11043
Bcr/CflA family multidrug efflux MFS transporter;
132-279 3.59e-05

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182924 [Multi-domain]  Cd Length: 401  Bit Score: 46.04  E-value: 3.59e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918  132 AILQLLVNPLSgpfiDRMSYDVPLLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAFADTSGIAMIADKYPEeperS 211
Cdd:PRK11043  55 ALGQLLWGPLS----DRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQAVGVCSAAVIWQALVIDRYPA----Q 126

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 13928918  212 RALGValaFISFGSLV------APPFGGILYEFAGKRVPFLVLAAVSLFdaLLLLAVAKPFSAAARARANLPVG 279
Cdd:PRK11043 127 KANRV---FATIMPLValspalAPLLGAWLLNHFGWQAIFATLFAITLL--LILPTLRLKPSKKARKQSQDALT 195
MFS_YjiJ cd06180
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ...
 155-447 4.87e-05

Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340869 [Multi-domain]  Cd Length: 371  Bit Score: 45.76  E-value: 4.87e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 155 LLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAFADTSGIAMIADKYPEEperSRALGVALAF------ISFGSLVA 228
Cdd:cd06180  67 IRGGLLLTVLLLAAMALTSGFAALLALRFLAGAASAFVFVFGSNLVLHHATAA---GRGHLIGLLFagvglgIALSGLLV 143

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 229 PPFGGILyefAGKRVPFLVLAAVSLFDALLLLAVAK-PFSAAARARANLPVGTPIHRLMLDPYIAVVAGAltTCNIPLAF 307
Cdd:cd06180 144 PAGLGGG---LSWRAGWLALALLSAVLLLLSFLLLRrGPSAPTEASAAESAPGLNRPLWRLALAYGLFGF--GYIITATF 218

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 308 LePTIATwmkhTMAASEWEMGMVWLPAFVPHVLGVYLTVRLAARYPHLQWLYGALGLAVIGVSSCVVpacrSFAPLVVSL 387
Cdd:cd06180 219 L-PLIAR----ETGAGSLLAGLLWSLFGLAAVPSCFLWGALSDRWGTRRALAANLLVQAVGVLLPLL----SPGPAGLVL 289

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 388 CGLCFGIALVDTALLpTLAFLVDVrHVSVYGSVYAIADISYSVAYALGPIVAGHIVHSLG 447
Cdd:cd06180 290 SAVLFGGTFMAITAL-VMALAREL-APPAAPRALALMTASFGVGQILGPLLAGWLADATG 347
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
125-270 5.42e-05

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 45.63  E-value: 5.42e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 125 GVLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVM-FASTVMFAFAEDYATLFAArSLQGLGSAFADTSGIAMIADK 203
Cdd:COG2807 253 GLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLgLAGLLGLLLAPGSLPWLWA-VLLGLGQGGLFPLALTLIGLR 331

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 13928918 204 YPEEPERSRALGVALAFISFGSLVAPPFGGILYEFAGK-RVPFLVLAAVSLFDALLLLAVAKPFSAAA 270
Cdd:COG2807 332 ARTPAEAAALSGMAQSVGYLLAALGPLLVGALHDATGSwTAALLLLAALAVLMLVAGLLAGRPYVEDA 399
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 132-260 6.57e-05

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 45.24  E-value: 6.57e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 132 AILQLLVNPLSGPFIDRMSYDVPLL--IGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAFAdTSGIAMIADKYPEEPE 209
Cdd:cd17352 228 GISDIVGRILLGLLADKPRIGRLYLyiFTLLILGLSLLAFPLATTYVGLIVFSVLFGFCSGSY-SSLTPVILADLVGLEK 306

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 13928918 210 RSRALGVALAFISFGSLVAPPFGGILYEFAGK-RVPFLVLAAVSLFDALLLL 260
Cdd:cd17352 307 LSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDyDAAFYFCGACLLLSGVLLF 358
PRK14995 PRK14995
SmvA family efflux MFS transporter;
147-237 8.31e-05

SmvA family efflux MFS transporter;


Pssm-ID: 184957 [Multi-domain]  Cd Length: 495  Bit Score: 45.10  E-value: 8.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918  147 DRMSYDVPLLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAFADTSGIAMIADKYPEEPERSRALGVALAFISFGSL 226
Cdd:PRK14995  66 DRIGFKRLLMLGGTLFGLASLAAAFSPTASWLIATRALLAIGAAMIVPATLAGIRATFTEEKQRNMALGVWAAVGSGGAA 145

                         90
                 ....*....|.
gi 13928918  227 VAPPFGGILYE 237
Cdd:PRK14995 146 FGPLVGGILLE 156
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 124-440 8.72e-05

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 44.86  E-value: 8.72e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 124 IGVLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAFADTSGIAMIADK 203
Cdd:cd17477  33 IGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNAL 112

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 204 YPEEpERSRALGVALAFISFGSLVAPPFGGILYEFAGkrVPFLVLAAVSLFdALLLLAVAKPFSAAARARANLPVGTPIH 283
Cdd:cd17477 113 ATNE-NRGRVLGLYSTVLGLGFALGPLLLALVGTAGA--LPFLIAAVLLLL-ALVPLLLTRRAAPEIEEAESISLRRLLR 188

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 284 RLMLDPYIAVVAGALTTCNIPLAflePTIATWMKHTMAASEWEMGMVWLPAfvphVLGVYLTVRLAARYPHLQWLygaLG 363
Cdd:cd17477 189 IAPLALLGAFVAGFLEGAFYSLL---PLYGLRLGLSVAQAALLLAAFVLGG----LLLQWPLGWLADRFDRRRVL---LG 258

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 13928918 364 LAVIGVSSCVVPACRSFAPLVVSLCGLCFGIALVdtALLPT-LAFLVDVRHVSVYGSVYAIADISYSVAYALGPIVAG 440
Cdd:cd17477 259 CALLGALAALLLPLVPGLPLALLVLLFLWGGAAG--PLYTLaLALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAG 334
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
125-272 8.84e-05

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 44.87  E-value: 8.84e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 125 GVLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVMFAFAEDYATLF-AARSLQGLGSAFADTSGIAMIADK 203
Cdd:COG2223 244 GLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFlVLFLLLGLALGGGNGAVFALVPDI 323

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 204 YPEEpERSRALGVALAFISFGSLVAPPFGGILYEFAGK-RVPFLVLAAVSLFDALLLLAVAKPFSAAARA 272
Cdd:COG2223 324 FPTK-NAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSyTAAFLVFAVLALVALVLTLLLYRRPRRAAAA 392
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 124-263 1.14e-04

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 44.49  E-value: 1.14e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 124 IGVLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAFADTSGIAMIADK 203
Cdd:cd17473 235 IGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSL 314

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 13928918 204 YPEEpERSRALGVALAFISFGSLVAPPFGGIL-YEFAGKRVPFLVLAAVSLFDALLLLAVA 263
Cdd:cd17473 315 VPPE-LRGRAMGIVTSAFFLGQFLSPLVLGPLvNLTGGLSGAFLILGVLALVLAIVLLLLR 374
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
132-401 1.28e-04

MdfA family multidrug efflux MFS transporter;


Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 44.54  E-value: 1.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918  132 AILQLLVNPLSgpfiDRMSYDVPLLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAFADTSGIAMIADKYPEEPE-R 210
Cdd:PRK15402  62 MFLQWLLGPLS----DRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIGLCFIGAVGYAAIQESFEEADAiK 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918  211 SRALGVALAFISfgSLVAPPFGGILYEFAGKRVPFLVLAAVSLFdALLLLAVAKPfSAAARARANLPVgtpihRLMLDPY 290
Cdd:PRK15402 138 ITALMANVALLA--PLLGPLVGAALIHVLPWRGMFVLFAALAAL-SFFGLWRAMP-ETAGRVGEKLSL-----KELGRDY 208

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918  291 IAV------VAGALTtcnIPLAFLePTIAtWMK-------HTMAASEWEMGMVWLPAFVPHVLGVYLTVRLAARYPHLQW 357
Cdd:PRK15402 209 KLVlknrrfVAGALA---LGLVSL-PLLA-WIAlspviliSGEQLSSYEYGLLQVPVFGALIAGNLTLARLTSRRPLRSL 283

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 13928918  358 LYGALGLAVIGVSSCVVPACRSFAPLVVSLCGL---CFGIALVDTAL 401
Cdd:PRK15402 284 IRMGLWPMVAGLLLAALATVISSHAYLWLTAGLslyAFGIGLANAGL 330
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
141-269 2.75e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 43.30  E-value: 2.75e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 141 LSGPFIDRMSYDVPLLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAFADTSGIAMIADKYPEEPerSRALGVALAF 220
Cdd:COG0738 265 LGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRT--AAAVSAVLIM 342

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 13928918 221 ISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLFDALLLLAVAKPFSAA 269
Cdd:COG0738 343 GIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRRKK 391
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
 124-264 3.57e-04

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 42.96  E-value: 3.57e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 124 IGVLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAFADTSGIAMIADK 203
Cdd:cd17335 235 IGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFALVWAAAVSYASAA 314

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 13928918 204 YPEEpERSRALGV--ALAF---ISFGSLVappfGGILYEFAGKRVPFLVLAAVSLFDALLLLAVAK 264
Cdd:cd17335 315 APPG-LRATAQGLlqGLYFglgGGLGSLI----GGYLYEAFGARTTFRFFAIAALAGLLAFFLIQR 375
MFS_FucP_like cd17394
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; ...
 142-235 4.16e-04

Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of L-fucose permease (also called L-fucose-proton symporter) and similar proteins such as glucose/galactose transporter and N-acetyl glucosamine transporter NagP. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. Glucose/galactose transporter functions in the uptake of of glucose and galactose. The FucP-like subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340952 [Multi-domain]  Cd Length: 401  Bit Score: 42.59  E-value: 4.16e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 142 SGPFIDRMSYDVPLLIGLGVMFASTVMFAFA---EDYATLFAARSLQGLGSAFADTSGIAMIADKYPEEPERSRaLGVAL 218
Cdd:cd17394  54 AGMLIKRYGYKKGILLGLGLYAIGALLFIPAaslRTYGLFLIALFVLASGLALLQTAANPYVTVLGPEETAARR-LNLAQ 132

                        90
                ....*....|....*..
gi 13928918 219 AFISFGSLVAPPFGGIL 235
Cdd:cd17394 133 AFNSLGSTIAPLFGSYL 149
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 141-258 7.49e-04

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 41.82  E-value: 7.49e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 141 LSGPFIDRMSYDVPLLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAFADTSGIAMIADKYPEEpERSRALGVALAF 220
Cdd:cd17316  55 LFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSK-RRGFALGLLQSG 133

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 13928918 221 ISFGSLVAPPFGGILYEFAGK----RVPFLVLAAVSLFDALL 258
Cdd:cd17316 134 WALGALLAALVASLLIPLLSGdwgwRILFLIGALPALLALLL 175
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 155-258 8.81e-04

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 41.48  E-value: 8.81e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 155 LLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAFADTSGIAMIADKYPEEPERSRALGVALAFISFGSLVAPPFGGI 234
Cdd:cd17476  66 FVIGSFWFAIWSLIAGFSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPPGPRKNIVFSLFGATAPLGFALGGVFGGL 145

                        90       100
                ....*....|....*....|....
gi 13928918 235 LYEFAGKRVPFLVLAAVSLFDALL 258
Cdd:cd17476 146 FAQLAWWPWIFWFLAILAAIVAVA 169
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 124-265 9.01e-04

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 41.59  E-value: 9.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918   124 IGVLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAFADTSGIAMIADK 203
Cdd:TIGR00881  32 LGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTKW 111

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 13928918   204 YPEEpERSRALGV-ALAFISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLFDALLLLAVAKP 265
Cdd:TIGR00881 112 FSRS-ERGTWVSFwNCSHNVGGGLLPPLVLFGIAELYSWHWVFIVPGIIAIIVSLICFLLLRD 173
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 156-268 1.15e-03

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 41.45  E-value: 1.15e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 156 LIGLGVMFASTVMF---AFAE-DYATLFAARSLQGLGSAFADTSGIAMIADKYPEEpERSRALGVALAFISFGSLVAPPF 231
Cdd:cd17318  88 VLGYSILITALLTLltpLAARgGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPL-ERSRLTSIAYSGSQFGTVIAMPL 166

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 13928918 232 GGILYEFAGKRVPFLVLAAVSLFDALLLLAVAKPFSA 268
Cdd:cd17318 167 SGFLCESLGWPSIFYIFGGLGLLWCLLWFFLVLPVWA 203
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 124-192 1.67e-03

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 40.64  E-value: 1.67e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 13928918 124 IGVLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVMFAFAE---DYATLFAARSLQGLGSAFA 192
Cdd:cd17503 216 SGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFLTpdtSLWLIILPLFIRGLGMGLV 287
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 124-367 4.32e-03

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 39.45  E-value: 4.32e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 124 IGVLFASKAILQLLVNPLSGPFIDR-MSYDVPLLIGLGVMFASTVMFAFAEDYAT-LFAARSLQGLGS-AFADTsgIAMI 200
Cdd:cd17471  34 IGIFMTLSALSGIVVSQWLGRLSDRgGDRKPLILLALLAGALGYLLFAFLRNYWVlLLVGVVLLSLGAaAFPQL--FALA 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 201 ADKYPEEPERSRALGVAL--AFISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLFDALLLLAVAKPFS--AAARARANL 276
Cdd:cd17471 112 REYADRSSGRDATLFNSVlrAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFLLPSVKppAQKATPASS 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 277 PVGTPIHRLMLDPYIAVV----AGALTTCNIPLafleptiatWMKHTMAASEWEMG-MVWLPAF--VPHVLgvyLTVRLA 349
Cdd:cd17471 192 LVKAPVNRRLLLLFAAFTllfaANSMYIIAMPL---------YVTNELGGSESWVGlLFGLAAAleIPIML---LAGLLA 259

                       250
                ....*....|....*...
gi 13928918 350 ARYPHLQWLYGALGLAVI 367
Cdd:cd17471 260 KRFGKRRLLLAGFLAGVL 277
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 122-259 4.56e-03

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 39.65  E-value: 4.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918   122 VKIGVLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAFADTSGIAMIA 201
Cdd:TIGR00895  52 VQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVS 131

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918   202 DKYpeePERSRALGVALAFISF--GSLVAPPFGGILYEFAGKRVPFLVLAAVSLFDALLL 259
Cdd:TIGR00895 132 EYA---PKRFRGTAVGLMFCGYpiGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLL 188
MFS_MFSD8 cd17326
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...
 125-235 5.42e-03

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340884 [Multi-domain]  Cd Length: 374  Bit Score: 39.11  E-value: 5.42e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 125 GVLFASKAILQLLVNPLSGPFIDRM-SYDVPLLIGLGVMFASTVMFAFAEDYAT-----LFAARSLQGLGSA-----FAD 193
Cdd:cd17326  39 GWVVAAYSLGQLVFSPVFGYWSNKTsSVKEPLIVSILIAIVGNILYALAEYFPSnrkyvMLVARFLIGVGAGnvavlRAY 118

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 13928918 194 TSGIAMIADkypeepeRSRALGVALAFISFGSLVAPPFGGIL 235
Cdd:cd17326 119 VAAASTLKD-------RTRAMAVISAAQALGFIVGPALQAAF 153
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
316-445 6.84e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 39.07  E-value: 6.84e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 316 MKHTMAASEWEMGMVWLPAFVPHVLGVYLTVRLAARYPHLQWLygALGLAVIGVSSCVVPACRSFAPLVVSLCGLCFGIA 395
Cdd:COG0738  34 LKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGL--LLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLG 111

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 13928918 396 LVDTALLPTLAFLVDVRHvsvyGSVYAIADISYSVAYALGPIVAGHIVHS 445
Cdd:COG0738 112 LLDVAANPYVAALGPETA----ASRLNLLHAFFSLGALLGPLLGGLLILL 157
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 165-367 9.00e-03

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 38.44  E-value: 9.00e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 165 STVMFAFAEDYATLFAARSLQGLGSAFADTSGIAMIADKYPEEpERSRALGVALAFISFGSLVAPPFGGILYEFAGK--- 241
Cdd:cd17371  77 FTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPAR-HRGKALGYVQSGWAVGWLLATLLAALLFPLLPPeia 155

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918 242 -RVPFLVLAAVSLFDALLLLAVAKPFSAAARARANLPVGTPIHRLMLDPYI---------AVVAGALTTCNIPLAFLePT 311
Cdd:cd17371 156 wRVLFLLGALPALLVLFIRRFVKEPPQWQAARAARRHFADRPSLRELFSPPllrttllasLLATGALGGYYGITTWL-PS 234

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 13928918 312 IATWMKH-TMAASEWEMGMVWLPAFVPHVLGVYLTVRLAARYphLQWLYGALGLAVI 367
Cdd:cd17371 235 YLTGERGlSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRN--NFALFALGSAISI 289
2A0114euk TIGR00894
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
 125-240 9.82e-03

Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]


Pssm-ID: 129972 [Multi-domain]  Cd Length: 465  Bit Score: 38.57  E-value: 9.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13928918   125 GVLFASKAILQLLVNPLSGPFIDRmsYDVPLLIGLGVMFASTVMF----AFAEDYATLFAARSLQGLGSAFADTSGIAMI 200
Cdd:TIGR00894  79 GLILSSHFYGQIIIQIPVGYLAGK--YVFKWSIGIGMFLSSVISIvipwAAGGGIALVVFCRVIQGLAQGSVSPATHKII 156

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 13928918   201 ADKYPEEpERSRALGVALAFISFGSLVAPPFGGILYEFAG 240
Cdd:TIGR00894 157 VKWAPPK-ERSRLLGMSTSGFQLGTFIFLPISGWLCESWG 195
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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