NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|29789283|ref|NP_115544|]
View 

WD repeat-containing protein 75 isoform 1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
20-316 6.65e-22

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.22  E-value: 6.65e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789283  20 RRAVFSADSKYIFCVSGD-FVKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLqLYSCSLDGTIKLWDYIDGILIKTFiv 98
Cdd:COG2319 124 RSVAFSPDGKTLASGSADgTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKL-LASGSDDGTVRLWDLATGKLLRTL-- 200

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789283  99 gcKLHalftlaqaEDSVF-VIVNkekPDIFQLVS------VKLPksssqEVEAKELSFVLDYINQSPKCIAFGNEGVYVA 171
Cdd:COG2319 201 --TGH--------TGAVRsVAFS---PDGKLLASgsadgtVRLW-----DLATGKLLRTLTGHSGSVRSVAFSPDGRLLA 262

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789283 172 AVREfYLSVYFFKKKTTSRFTLsssrnKKHAKNNFTCVACHPTEDCIASGHMDGKIRLWRnfYDDKKYTYTcLHWHHDMV 251
Cdd:COG2319 263 SGSA-DGTVRLWDLATGELLRT-----LTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWD--LATGKLLRT-LTGHTGAV 333

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 29789283 252 MDLAFSVTGTSLLSGGRESVLVEWRDATEKNKEFLPRLGATIEHISVSPAGDLFCTSHSDNKIII 316
Cdd:COG2319 334 RSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
207-525 4.11e-14

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 75.33  E-value: 4.11e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789283 207 TCVACHPTEDCIASGHMDGKIRLWRnfYDDKKYTYTcLHWHHDMVMDLAFSVTGTSLLSGGRESVLVEWRDATEKNKEFL 286
Cdd:COG2319 124 RSVAFSPDGKTLASGSADGTVRLWD--LATGKLLRT-LTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL 200

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789283 287 PRLGATIEHISVSPAGDLFCTSHSDNKIIIIhrNLEASAVIQGLVKDRSIFTGLMIDPRTKALVLNGKPGHLQFYSLQSD 366
Cdd:COG2319 201 TGHTGAVRSVAFSPDGKLLASGSADGTVRLW--DLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG 278

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789283 367 KQLYNLDIIQQeyindygliqiELTKAAFGCFGNWLATVEQRQeketelelQMKLWMYNKKTQGFILNtkinmPHEDCIT 446
Cdd:COG2319 279 ELLRTLTGHSG-----------GVNSVAFSPDGKLLASGSDDG--------TVRLWDLATGKLLRTLT-----GHTGAVR 334

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789283 447 ALCFCNAEKseqpTLVTASKDGYFKVWILTDDSDIYKkavgwtcdFVGsyHKYQATNCCFSEDGSLLAV-SFEEIVTIWD 525
Cdd:COG2319 335 SVAFSPDGK----TLASGSDDGTVRLWDLATGELLRT--------LTG--HTGAVTSVAFSPDGRTLASgSADGTVRLWD 400
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
20-316 6.65e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.22  E-value: 6.65e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789283  20 RRAVFSADSKYIFCVSGD-FVKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLqLYSCSLDGTIKLWDYIDGILIKTFiv 98
Cdd:COG2319 124 RSVAFSPDGKTLASGSADgTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKL-LASGSDDGTVRLWDLATGKLLRTL-- 200

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789283  99 gcKLHalftlaqaEDSVF-VIVNkekPDIFQLVS------VKLPksssqEVEAKELSFVLDYINQSPKCIAFGNEGVYVA 171
Cdd:COG2319 201 --TGH--------TGAVRsVAFS---PDGKLLASgsadgtVRLW-----DLATGKLLRTLTGHSGSVRSVAFSPDGRLLA 262

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789283 172 AVREfYLSVYFFKKKTTSRFTLsssrnKKHAKNNFTCVACHPTEDCIASGHMDGKIRLWRnfYDDKKYTYTcLHWHHDMV 251
Cdd:COG2319 263 SGSA-DGTVRLWDLATGELLRT-----LTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWD--LATGKLLRT-LTGHTGAV 333

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 29789283 252 MDLAFSVTGTSLLSGGRESVLVEWRDATEKNKEFLPRLGATIEHISVSPAGDLFCTSHSDNKIII 316
Cdd:COG2319 334 RSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 20-316 3.68e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 94.71  E-value: 3.68e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789283  20 RRAVFSADSKYIFCVSGD-FVKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLqLYSCSLDGTIKLWDyidgiliktfiv 98
Cdd:cd00200  55 RDVAASADGTYLASGSSDkTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRI-LSSSSRDKTIKVWD------------ 121

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789283  99 gcklhalftlaqaedsvfvivnkekpdifqlvsvklpksssqeVEAKELSFVLDYINQSPKCIAF-GNEGVYVAAVREFY 177
Cdd:cd00200 122 -------------------------------------------VETGKCLTTLRGHTDWVNSVAFsPDGTFVASSSQDGT 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789283 178 LSVYFFKkkttsrfTLSSSRNKKHAKNNFTCVACHPTEDCIASGHMDGKIRLWRNFYDDKKYTYTClhwHHDMVMDLAFS 257
Cdd:cd00200 159 IKLWDLR-------TGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRG---HENGVNSVAFS 228

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 29789283 258 VTGTSLLSGGRESVLVEWRDATEKNKEFLPRLGATIEHISVSPAGDLFCTSHSDNKIII 316
Cdd:cd00200 229 PDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
207-525 4.11e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 75.33  E-value: 4.11e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789283 207 TCVACHPTEDCIASGHMDGKIRLWRnfYDDKKYTYTcLHWHHDMVMDLAFSVTGTSLLSGGRESVLVEWRDATEKNKEFL 286
Cdd:COG2319 124 RSVAFSPDGKTLASGSADGTVRLWD--LATGKLLRT-LTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL 200

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789283 287 PRLGATIEHISVSPAGDLFCTSHSDNKIIIIhrNLEASAVIQGLVKDRSIFTGLMIDPRTKALVLNGKPGHLQFYSLQSD 366
Cdd:COG2319 201 TGHTGAVRSVAFSPDGKLLASGSADGTVRLW--DLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG 278

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789283 367 KQLYNLDIIQQeyindygliqiELTKAAFGCFGNWLATVEQRQeketelelQMKLWMYNKKTQGFILNtkinmPHEDCIT 446
Cdd:COG2319 279 ELLRTLTGHSG-----------GVNSVAFSPDGKLLASGSDDG--------TVRLWDLATGKLLRTLT-----GHTGAVR 334

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789283 447 ALCFCNAEKseqpTLVTASKDGYFKVWILTDDSDIYKkavgwtcdFVGsyHKYQATNCCFSEDGSLLAV-SFEEIVTIWD 525
Cdd:COG2319 335 SVAFSPDGK----TLASGSDDGTVRLWDLATGELLRT--------LTG--HTGAVTSVAFSPDGRTLASgSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 207-535 6.21e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.12  E-value: 6.21e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789283 207 TCVACHPTEDCIASGHMDGKIRLWRNFYDDKKYTYTClhwHHDMVMDLAFSVTGTSLLSGGRESVLVEWR-DATEKNKEF 285
Cdd:cd00200  13 TCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKG---HTGPVRDVAASADGTYLASGSSDKTIRLWDlETGECVRTL 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789283 286 LPRLGAtIEHISVSPAGDLFCTSHSDNKIIIihrnleasaviqglvkdrsiftglmidprtkalvlngkpghlqfYSLQS 365
Cdd:cd00200  90 TGHTSY-VSSVAFSPDGRILSSSSRDKTIKV--------------------------------------------WDVET 124

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789283 366 DKQLYNLdiiqqEYINDYgliqieLTKAAFGCFGNWLATVEQrqeketelELQMKLWmyNKKTQGFIlntKINMPHEDCI 445
Cdd:cd00200 125 GKCLTTL-----RGHTDW------VNSVAFSPDGTFVASSSQ--------DGTIKLW--DLRTGKCV---ATLTGHTGEV 180

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789283 446 TALCFCNAEKSeqptLVTASKDGYFKVWiltddsDIYKKAvgWTCDFVGsyHKYQATNCCFSEDGSLLAVSFEEIVT-IW 524
Cdd:cd00200 181 NSVAFSPDGEK----LLSSSSDGTIKLW------DLSTGK--CLGTLRG--HENGVNSVAFSPDGYLLASGSEDGTIrVW 246

                       330
                ....*....|.
gi 29789283 525 DSVTWELKCTF 535
Cdd:cd00200 247 DLRTGECVQTL 257
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 46-86 9.11e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.54  E-value: 9.11e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 29789283     46 TEECVHILHGHRNLVTGIQLNPNNHLqLYSCSLDGTIKLWD 86
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
48-86 1.58e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.11  E-value: 1.58e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 29789283    48 ECVHILHGHRNLVTGIQLNPNNHLqLYSCSLDGTIKLWD 86
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
20-316 6.65e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.22  E-value: 6.65e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789283  20 RRAVFSADSKYIFCVSGD-FVKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLqLYSCSLDGTIKLWDYIDGILIKTFiv 98
Cdd:COG2319 124 RSVAFSPDGKTLASGSADgTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKL-LASGSDDGTVRLWDLATGKLLRTL-- 200

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789283  99 gcKLHalftlaqaEDSVF-VIVNkekPDIFQLVS------VKLPksssqEVEAKELSFVLDYINQSPKCIAFGNEGVYVA 171
Cdd:COG2319 201 --TGH--------TGAVRsVAFS---PDGKLLASgsadgtVRLW-----DLATGKLLRTLTGHSGSVRSVAFSPDGRLLA 262

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789283 172 AVREfYLSVYFFKKKTTSRFTLsssrnKKHAKNNFTCVACHPTEDCIASGHMDGKIRLWRnfYDDKKYTYTcLHWHHDMV 251
Cdd:COG2319 263 SGSA-DGTVRLWDLATGELLRT-----LTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWD--LATGKLLRT-LTGHTGAV 333

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 29789283 252 MDLAFSVTGTSLLSGGRESVLVEWRDATEKNKEFLPRLGATIEHISVSPAGDLFCTSHSDNKIII 316
Cdd:COG2319 334 RSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 20-316 3.68e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 94.71  E-value: 3.68e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789283  20 RRAVFSADSKYIFCVSGD-FVKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLqLYSCSLDGTIKLWDyidgiliktfiv 98
Cdd:cd00200  55 RDVAASADGTYLASGSSDkTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRI-LSSSSRDKTIKVWD------------ 121

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789283  99 gcklhalftlaqaedsvfvivnkekpdifqlvsvklpksssqeVEAKELSFVLDYINQSPKCIAF-GNEGVYVAAVREFY 177
Cdd:cd00200 122 -------------------------------------------VETGKCLTTLRGHTDWVNSVAFsPDGTFVASSSQDGT 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789283 178 LSVYFFKkkttsrfTLSSSRNKKHAKNNFTCVACHPTEDCIASGHMDGKIRLWRNFYDDKKYTYTClhwHHDMVMDLAFS 257
Cdd:cd00200 159 IKLWDLR-------TGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRG---HENGVNSVAFS 228

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 29789283 258 VTGTSLLSGGRESVLVEWRDATEKNKEFLPRLGATIEHISVSPAGDLFCTSHSDNKIII 316
Cdd:cd00200 229 PDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
20-279 1.44e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 85.73  E-value: 1.44e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789283  20 RRAVFSADSKYIFCVSGDF-VKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLqLYSCSLDGTIKLWDYIDGILIKTFiv 98
Cdd:COG2319 166 TSVAFSPDGKLLASGSDDGtVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKL-LASGSADGTVRLWDLATGKLLRTL-- 242

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789283  99 gcKLHalftlaqaEDSVF-VIVNkekPDIFQLVSVklpkSSSQEV-----EAKELSFVLDYINQSPKCIAFGNEGVYVAA 172
Cdd:COG2319 243 --TGH--------SGSVRsVAFS---PDGRLLASG----SADGTVrlwdlATGELLRTLTGHSGGVNSVAFSPDGKLLAS 305

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789283 173 VREFYlSVYFFKKKT-TSRFTLSSSRNKkhaknnFTCVACHPTEDCIASGHMDGKIRLWRNfyDDKKYTYTcLHWHHDMV 251
Cdd:COG2319 306 GSDDG-TVRLWDLATgKLLRTLTGHTGA------VRSVAFSPDGKTLASGSDDGTVRLWDL--ATGELLRT-LTGHTGAV 375

                       250       260
                ....*....|....*....|....*...
gi 29789283 252 MDLAFSVTGTSLLSGGRESVLVEWRDAT 279
Cdd:COG2319 376 TSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
20-372 4.31e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.19  E-value: 4.31e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789283  20 RRAVFSADSKYIFCVSGDF-VKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLqLYSCSLDGTIKLWDYIDGILIKTFiv 98
Cdd:COG2319  82 LSVAFSPDGRLLASASADGtVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKT-LASGSADGTVRLWDLATGKLLRTL-- 158

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789283  99 gcKLHAlftlaqaedsvfvivnkekpdifqlvsvklpksssqeveakelsfvlDYINqspkCIAFGNEGVYVAAVREFYl 178
Cdd:COG2319 159 --TGHS-----------------------------------------------GAVT----SVAFSPDGKLLASGSDDG- 184

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789283 179 SVYFFKKKT-TSRFTLsssrnKKHaKNNFTCVACHPTEDCIASGHMDGKIRLWRnfYDDKKYTYTcLHWHHDMVMDLAFS 257
Cdd:COG2319 185 TVRLWDLATgKLLRTL-----TGH-TGAVRSVAFSPDGKLLASGSADGTVRLWD--LATGKLLRT-LTGHSGSVRSVAFS 255

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789283 258 VTGTSLLSGGRESVLVEWRDATEKNKEFLPRLGATIEHISVSPAGDLFCTSHSDNKIIIIhrNLEASAVIQGLVKDRSIF 337
Cdd:COG2319 256 PDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW--DLATGKLLRTLTGHTGAV 333

                       330       340       350
                ....*....|....*....|....*....|....*
gi 29789283 338 TGLMIDPRTKALVLNGKPGHLQFYSLQSDKQLYNL 372
Cdd:COG2319 334 RSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTL 368
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 49-372 1.19e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 81.23  E-value: 1.19e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789283  49 CVHILHGHRNLVTGIQLNPNNHLqLYSCSLDGTIKLWDYIDGILIKTFivgcKLHALFtlaqAEDSVFVivnkekPDIFQ 128
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKL-LATGSGDGTIKVWDLETGELLRTL----KGHTGP----VRDVAAS------ADGTY 65

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789283 129 LVSVKLPKSSSqeveakelsfVLDYinQSPKCIafgnegvyvaavREFylsvyffkkkttsrftlsssrnkKHAKNNFTC 208
Cdd:cd00200  66 LASGSSDKTIR----------LWDL--ETGECV------------RTL-----------------------TGHTSYVSS 98

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789283 209 VACHPTEDCIASGHMDGKIRLWRNFYDDKKYTYTClhwHHDMVMDLAFSVTGTSLLSGGRESVLVEWRDATEKNKEFLPR 288
Cdd:cd00200  99 VAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRG---HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTG 175

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789283 289 LGATIEHISVSPAGDLFCTSHSDNKIIIIhrNLEASAVIQGLVKDRSIFTGLMIDPRTKALVLNGKPGHLQFYSLQSDKQ 368
Cdd:cd00200 176 HTGEVNSVAFSPDGEKLLSSSSDGTIKLW--DLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGEC 253


                ....
gi 29789283 369 LYNL 372
Cdd:cd00200 254 VQTL 257
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 24-231 1.13e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 78.53  E-value: 1.13e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789283  24 FSADSKYIFCVSGDF-VKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLqLYSCSLDGTIKLWDYIDGILIKTFivgcKL 102
Cdd:cd00200 101 FSPDGRILSSSSRDKtIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTF-VASSSQDGTIKLWDLRTGKCVATL----TG 175

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789283 103 HalftlaqaEDSVFVIVNkeKPDIFQLVS------VKLPKSSSQEvEAKELSFVLDYINqspkCIAFGNEGVYVAAVREf 176
Cdd:cd00200 176 H--------TGEVNSVAF--SPDGEKLLSsssdgtIKLWDLSTGK-CLGTLRGHENGVN----SVAFSPDGYLLASGSE- 239

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 29789283 177 YLSVYFFKKKTTSR-FTLSSsrnkkHaKNNFTCVACHPTEDCIASGHMDGKIRLWR 231
Cdd:cd00200 240 DGTIRVWDLRTGECvQTLSG-----H-TNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
207-525 4.11e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 75.33  E-value: 4.11e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789283 207 TCVACHPTEDCIASGHMDGKIRLWRnfYDDKKYTYTcLHWHHDMVMDLAFSVTGTSLLSGGRESVLVEWRDATEKNKEFL 286
Cdd:COG2319 124 RSVAFSPDGKTLASGSADGTVRLWD--LATGKLLRT-LTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL 200

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789283 287 PRLGATIEHISVSPAGDLFCTSHSDNKIIIIhrNLEASAVIQGLVKDRSIFTGLMIDPRTKALVLNGKPGHLQFYSLQSD 366
Cdd:COG2319 201 TGHTGAVRSVAFSPDGKLLASGSADGTVRLW--DLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG 278

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789283 367 KQLYNLDIIQQeyindygliqiELTKAAFGCFGNWLATVEQRQeketelelQMKLWMYNKKTQGFILNtkinmPHEDCIT 446
Cdd:COG2319 279 ELLRTLTGHSG-----------GVNSVAFSPDGKLLASGSDDG--------TVRLWDLATGKLLRTLT-----GHTGAVR 334

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789283 447 ALCFCNAEKseqpTLVTASKDGYFKVWILTDDSDIYKkavgwtcdFVGsyHKYQATNCCFSEDGSLLAV-SFEEIVTIWD 525
Cdd:COG2319 335 SVAFSPDGK----TLASGSDDGTVRLWDLATGELLRT--------LTG--HTGAVTSVAFSPDGRTLASgSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
209-570 9.68e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 67.63  E-value: 9.68e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789283 209 VACHPTEDCIASGHMDGKIRLWRnfyDDKKYTYTCLHWHHDMVMDLAFSVTGTSLLSGGRESVLVEWRDATEKNKEFLPR 288
Cdd:COG2319  84 VAFSPDGRLLASASADGTVRLWD---LATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789283 289 LGATIEHISVSPAGDLFCTSHSDNKIIIihRNLEASAVIQGLVKDRSIFTGLMIDPRTKALVLNGKPGHLQFYSLQSDKQ 368
Cdd:COG2319 161 HSGAVTSVAFSPDGKLLASGSDDGTVRL--WDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKL 238

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789283 369 LYNLDiIQQEYINDygliqieltkAAF--GcfGNWLATVEQRQeketelelQMKLWmyNKKTqGFILNTKinMPHEDCIT 446
Cdd:COG2319 239 LRTLT-GHSGSVRS----------VAFspD--GRLLASGSADG--------TVRLW--DLAT-GELLRTL--TGHSGGVN 292

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789283 447 ALCFCNAEKseqpTLVTASKDGYFKVWiltddsDIYKKAVGWTcdFVGsyHKYQATNCCFSEDGSLLAV-SFEEIVTIWD 525
Cdd:COG2319 293 SVAFSPDGK----LLASGSDDGTVRLW------DLATGKLLRT--LTG--HTGAVRSVAFSPDGKTLASgSDDGTVRLWD 358

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*...
gi 29789283 526 SVTWELKCTFCQRAGKIRHLCF---GRltcskYLLGATENGILCCWNL 570
Cdd:COG2319 359 LATGELLRTLTGHTGAVTSVAFspdGR-----TLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 14-96 1.27e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 63.12  E-value: 1.27e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789283  14 GSELNFRRAVFSADSKYIFCVSGD-FVKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLqLYSCSLDGTIKLWDYIDGIL 92
Cdd:cd00200 175 GHTGEVNSVAFSPDGEKLLSSSSDgTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYL-LASGSEDGTIRVWDLRTGEC 253


                ....
gi 29789283  93 IKTF 96
Cdd:cd00200 254 VQTL 257
WD40 COG2319
WD40 repeat [General function prediction only];
13-96 2.25e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.39  E-value: 2.25e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789283  13 GGSELNFRRAVFSADSKYIFCVSGDF-VKVYSTVTEECVHILHGHRNLVTGIQLNPNNHLqLYSCSLDGTIKLWDYIDGI 91
Cdd:COG2319 243 TGHSGSVRSVAFSPDGRLLASGSADGtVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKL-LASGSDDGTVRLWDLATGK 321


                ....*
gi 29789283  92 LIKTF 96
Cdd:COG2319 322 LLRTL 326
WD40 COG2319
WD40 repeat [General function prediction only];
244-570 2.48e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.39  E-value: 2.48e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789283 244 LHWHHDMVMDLAFSVTGTSLLSGGRESVLVEWRDATEKNKEFLPRLGATIEHISVSPAGDLFCTSHSDNKIIIihRNLEA 323
Cdd:COG2319  32 LLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRL--WDLAT 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789283 324 SAVIQGLVKDRSIFTGLMIDPRTKALVLNGKPGHLQFYSLQSDKQLYNLDIiQQEYINDygliqieltkAAFGCFGNWLA 403
Cdd:COG2319 110 GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG-HSGAVTS----------VAFSPDGKLLA 178

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789283 404 TVEQRQeketelelQMKLWmyNKKTQGFILNTKinmPHEDCITALCFCNAEKseqpTLVTASKDGYFKVWiltddsDIYK 483
Cdd:COG2319 179 SGSDDG--------TVRLW--DLATGKLLRTLT---GHTGAVRSVAFSPDGK----LLASGSADGTVRLW------DLAT 235

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789283 484 KAVGWTcdFVGsyHKYQATNCCFSEDGSLLAV-SFEEIVTIWDSVTWELKCTFCQRAGKIRHLCF---GRltcskYLLGA 559
Cdd:COG2319 236 GKLLRT--LTG--HSGSVRSVAFSPDGRLLASgSADGTVRLWDLATGELLRTLTGHSGGVNSVAFspdGK-----LLASG 306

                       330
                ....*....|.
gi 29789283 560 TENGILCCWNL 570
Cdd:COG2319 307 SDDGTVRLWDL 317
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 12-86 8.70e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 60.81  E-value: 8.70e-10
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 29789283  12 CGGSELNFRRAVFSADSKYIFCVSGDF-VKVYSTVTEECVHILHGHRNLVTGIQLNPNNHlQLYSCSLDGTIKLWD 86
Cdd:cd00200 215 LRGHENGVNSVAFSPDGYLLASGSEDGtIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGK-RLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 207-535 6.21e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.12  E-value: 6.21e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789283 207 TCVACHPTEDCIASGHMDGKIRLWRNFYDDKKYTYTClhwHHDMVMDLAFSVTGTSLLSGGRESVLVEWR-DATEKNKEF 285
Cdd:cd00200  13 TCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKG---HTGPVRDVAASADGTYLASGSSDKTIRLWDlETGECVRTL 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789283 286 LPRLGAtIEHISVSPAGDLFCTSHSDNKIIIihrnleasaviqglvkdrsiftglmidprtkalvlngkpghlqfYSLQS 365
Cdd:cd00200  90 TGHTSY-VSSVAFSPDGRILSSSSRDKTIKV--------------------------------------------WDVET 124

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789283 366 DKQLYNLdiiqqEYINDYgliqieLTKAAFGCFGNWLATVEQrqeketelELQMKLWmyNKKTQGFIlntKINMPHEDCI 445
Cdd:cd00200 125 GKCLTTL-----RGHTDW------VNSVAFSPDGTFVASSSQ--------DGTIKLW--DLRTGKCV---ATLTGHTGEV 180

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789283 446 TALCFCNAEKSeqptLVTASKDGYFKVWiltddsDIYKKAvgWTCDFVGsyHKYQATNCCFSEDGSLLAVSFEEIVT-IW 524
Cdd:cd00200 181 NSVAFSPDGEK----LLSSSSDGTIKLW------DLSTGK--CLGTLRG--HENGVNSVAFSPDGYLLASGSEDGTIrVW 246

                       330
                ....*....|.
gi 29789283 525 DSVTWELKCTF 535
Cdd:cd00200 247 DLRTGECVQTL 257
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 46-86 9.11e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.54  E-value: 9.11e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 29789283     46 TEECVHILHGHRNLVTGIQLNPNNHLqLYSCSLDGTIKLWD 86
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
48-86 1.58e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.11  E-value: 1.58e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 29789283    48 ECVHILHGHRNLVTGIQLNPNNHLqLYSCSLDGTIKLWD 86
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 441-573 1.48e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.80  E-value: 1.48e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789283 441 HEDCITALCFCnaekSEQPTLVTASKDGYFKVWiltDDSDIYKKAVgwtcdFVGsyHKYQATNCCFSEDGSLLAVSFEE- 519
Cdd:cd00200 134 HTDWVNSVAFS----PDGTFVASSSQDGTIKLW---DLRTGKCVAT-----LTG--HTGEVNSVAFSPDGEKLLSSSSDg 199

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 29789283 520 IVTIWDSVTWELKCTFCQRAGKIRHLCFgrLTCSKYLLGATENGILCCWNLLSC 573
Cdd:cd00200 200 TIKLWDLSTGKCLGTLRGHENGVNSVAF--SPDGYLLASGSEDGTIRVWDLRTG 251
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 207-230 1.71e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 1.71e-03
                           10        20
                   ....*....|....*....|....
gi 29789283    207 TCVACHPTEDCIASGHMDGKIRLW 230
Cdd:smart00320  16 TSVAFSPDGKYLASGSDDGTIKLW 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 441-572 4.39e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.01  E-value: 4.39e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789283 441 HEDCITALCFCNaeksEQPTLVTASKDGYFKVWILTDDSDIYKkavgwtcdFVGSYHKYQATNCCfSEDGSLLAVSFEEI 520
Cdd:cd00200   8 HTGGVTCVAFSP----DGKLLATGSGDGTIKVWDLETGELLRT--------LKGHTGPVRDVAAS-ADGTYLASGSSDKT 74

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 29789283 521 VTIWDSVTWELKCTFCQRAGKIRHLCFgrLTCSKYLLGATENGILCCWNLLS 572
Cdd:cd00200  75 IRLWDLETGECVRTLTGHTSYVSSVAF--SPDGRILSSSSRDKTIKVWDVET 124
WD40 pfam00400
WD domain, G-beta repeat;
207-230 7.08e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 7.08e-03
                          10        20
                  ....*....|....*....|....
gi 29789283   207 TCVACHPTEDCIASGHMDGKIRLW 230
Cdd:pfam00400  15 TSLAFSPDGKLLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH