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Conserved domains on  [gi|40217825|ref|NP_115605|]
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SLIT and NTRK-like protein 6 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
363-517 3.74e-16

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.52  E-value: 3.74e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40217825 363 QNPRKLILAGNIIHSLmkSDLVEYFT-LEMLHLGNNRIEVLEEgSFMNLTRLQKLYLNGNHLTKLSKGmFLGLHNLEYLY 441
Cdd:COG4886 113 TNLESLDLSGNQLTDL--PEELANLTnLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELD 188

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 40217825 442 LEYNAIKEiLPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGVPLTKVNLKTNQFTHLPVsniLDDLDLLTQIDLEDN 517
Cdd:COG4886 189 LSNNQITD-LPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE---LGNLTNLEELDLSNN 260
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
68-213 2.50e-15

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.21  E-value: 2.50e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40217825  68 QLSLLNNGLTMLhTNDFSGLTNAISIHLGFNNIADI--EIGAFNGLgllKQLHINHNSLEILKEDtFHGLENLEFLQADN 145
Cdd:COG4886 117 SLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLpePLGNLTNL---KSLDLSNNQLTDLPEE-LGNLTNLKELDLSN 191

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 40217825 146 NFITVIePSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLTHLDLRGNQLQTLPYVGFLEHIgRILDL 213
Cdd:COG4886 192 NQITDL-PEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNL-EELDL 257
LRRCT smart00082
Leucine rich repeat C-terminal domain;
517-567 8.12e-07

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 46.65  E-value: 8.12e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 40217825    517 NPWDCSCDLVGLQQWIQKLSKNTVTDDILCTSPGHLDKKELKALNSEILCP 567
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGPLLELLHSEFKCP 51
LRRCT super family cl47026
Leucine rich repeat C-terminal domain;
218-268 1.62e-04

Leucine rich repeat C-terminal domain;


The actual alignment was detected with superfamily member smart00082:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 40.11  E-value: 1.62e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 40217825    218 NKWACNCDLLQLKTWLEN--MPPQSiiGDVVCNSPPFFKGSILSRLKKESICP 268
Cdd:smart00082   1 NPFICDCELRWLLRWLQAneHLQDP--VDLRCASPSSLRGPLLELLHSEFKCP 51
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
363-517 3.74e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.52  E-value: 3.74e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40217825 363 QNPRKLILAGNIIHSLmkSDLVEYFT-LEMLHLGNNRIEVLEEgSFMNLTRLQKLYLNGNHLTKLSKGmFLGLHNLEYLY 441
Cdd:COG4886 113 TNLESLDLSGNQLTDL--PEELANLTnLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELD 188

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 40217825 442 LEYNAIKEiLPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGVPLTKVNLKTNQFTHLPVsniLDDLDLLTQIDLEDN 517
Cdd:COG4886 189 LSNNQITD-LPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE---LGNLTNLEELDLSNN 260
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
68-213 2.50e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.21  E-value: 2.50e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40217825  68 QLSLLNNGLTMLhTNDFSGLTNAISIHLGFNNIADI--EIGAFNGLgllKQLHINHNSLEILKEDtFHGLENLEFLQADN 145
Cdd:COG4886 117 SLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLpePLGNLTNL---KSLDLSNNQLTDLPEE-LGNLTNLKELDLSN 191

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 40217825 146 NFITVIePSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLTHLDLRGNQLQTLPYVGFLEHIgRILDL 213
Cdd:COG4886 192 NQITDL-PEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNL-EELDL 257
LRR_8 pfam13855
Leucine rich repeat;
411-471 1.14e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 66.01  E-value: 1.14e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 40217825   411 TRLQKLYLNGNHLTKLSKGMFLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNLL 471
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 345-518 5.12e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 65.96  E-value: 5.12e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40217825 345 IHCQERNIESLSDLRPPPqNPRKLILAGNIIHSLmkSDLVEYFTLEMLHLGNNRIEVLEegSFMNLTRLQKLYLNGNHLT 424
Cdd:cd21340   7 LYLNDKNITKIDNLSLCK-NLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNRIS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40217825 425 KLSkGmFLGLHNLEYLYLEYNAIKEILPGTFNPM------PKLKVLYLNNNLLQVLPPhIFSGVPLTKVNLKTNQFTHL- 497
Cdd:cd21340  82 VVE-G-LENLTNLEELHIENQRLPPGEKLTFDPRslaalsNSLRVLNISGNNIDSLEP-LAPLRNLEQLDASNNQISDLe 158

                       170       180
                ....*....|....*....|.
gi 40217825 498 PVSNILDDLDLLTQIDLEDNP 518
Cdd:cd21340 159 ELLDLLSSWPSLRELDLTGNP 179
LRR_8 pfam13855
Leucine rich repeat;
137-195 4.19e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.30  E-value: 4.19e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 40217825   137 NLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVP-LTHLDLRGNQL 195
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPsLRYLDLSGNRL 61
LRRCT smart00082
Leucine rich repeat C-terminal domain;
517-567 8.12e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 46.65  E-value: 8.12e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 40217825    517 NPWDCSCDLVGLQQWIQKLSKNTVTDDILCTSPGHLDKKELKALNSEILCP 567
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGPLLELLHSEFKCP 51
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 68-199 8.53e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.86  E-value: 8.53e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40217825  68 QLSLLNNGLTMLhtNDFSGLTNAISIHLGFNNIADIEigAFNGLGLLKQLHINHNSLE-----ILKEDTFHGL-ENLEFL 141
Cdd:cd21340  50 HLYLQNNQIEKI--ENLENLVNLKKLYLGGNRISVVE--GLENLTNLEELHIENQRLPpgeklTFDPRSLAALsNSLRVL 125

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 40217825 142 QADNNFITVIEPsaFSKLNRLKVLILNDNAIESLP---PNIFRFVPLTHLDLRGNQLQTLP 199
Cdd:cd21340 126 NISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEellDLLSSWPSLRELDLTGNPVCKKP 184
LRRCT smart00082
Leucine rich repeat C-terminal domain;
218-268 1.62e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 40.11  E-value: 1.62e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 40217825    218 NKWACNCDLLQLKTWLEN--MPPQSiiGDVVCNSPPFFKGSILSRLKKESICP 268
Cdd:smart00082   1 NPFICDCELRWLLRWLQAneHLQDP--VDLRCASPSSLRGPLLELLHSEFKCP 51
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 69-494 3.10e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.45  E-value: 3.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40217825   69 LSLLNNGLTMLHTNDFSGLTNAISIHLGFNNIAD---IEIGafnGLGLLKQLHINHNSLEILKEDTFHGLENLEFL-QAD 144
Cdd:PLN00113 193 LTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGeipYEIG---GLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLfLYQ 269

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40217825  145 NNFITVIEPSAFSkLNRLKVLILNDNAIE-SLPPNIFRFVPLTHLDLRGNQLQ-TLPyvGFLEHIGRILDLQLEDNKWAC 222
Cdd:PLN00113 270 NKLSGPIPPSIFS-LQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFTgKIP--VALTSLPRLQVLQLWSNKFSG 346

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40217825  223 ----------NCDLLQLKTwlENMPPQsiIGDVVCNSPPFFKGSILSRLKKESICPTppvyeehedpsgslhLAATSSIN 292
Cdd:PLN00113 347 eipknlgkhnNLTVLDLST--NNLTGE--IPEGLCSSGNLFKLILFSNSLEGEIPKS---------------LGACRSLR 407

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40217825  293 DSRMSTKTTSiLKLP---TKAPgLIPYITKPSTQLPGpycpipcnckvlspsgllihcqerNIESLSDLRPPPQnprKLI 369
Cdd:PLN00113 408 RVRLQDNSFS-GELPsefTKLP-LVYFLDISNNNLQG------------------------RINSRKWDMPSLQ---MLS 458

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40217825  370 LAGNIIHSLMkSDLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSKGMFLGLHNLEYLYLEYNAIKE 449
Cdd:PLN00113 459 LARNKFFGGL-PDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSG 537

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*.
gi 40217825  450 ILPGTFNPMPKLKVLYLNNNLLQ-VLPPHIFSGVPLTKVNLKTNQF 494
Cdd:PLN00113 538 QIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISHNHL 583
LRR smart00370
Leucine-rich repeats, outliers;
458-481 8.32e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 34.63  E-value: 8.32e-03
                           10        20
                   ....*....|....*....|....
gi 40217825    458 MPKLKVLYLNNNLLQVLPPHIFSG 481
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
363-517 3.74e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.52  E-value: 3.74e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40217825 363 QNPRKLILAGNIIHSLmkSDLVEYFT-LEMLHLGNNRIEVLEEgSFMNLTRLQKLYLNGNHLTKLSKGmFLGLHNLEYLY 441
Cdd:COG4886 113 TNLESLDLSGNQLTDL--PEELANLTnLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELD 188

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 40217825 442 LEYNAIKEiLPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGVPLTKVNLKTNQFTHLPVsniLDDLDLLTQIDLEDN 517
Cdd:COG4886 189 LSNNQITD-LPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE---LGNLTNLEELDLSNN 260
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
68-213 2.50e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.21  E-value: 2.50e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40217825  68 QLSLLNNGLTMLhTNDFSGLTNAISIHLGFNNIADI--EIGAFNGLgllKQLHINHNSLEILKEDtFHGLENLEFLQADN 145
Cdd:COG4886 117 SLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLpePLGNLTNL---KSLDLSNNQLTDLPEE-LGNLTNLKELDLSN 191

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 40217825 146 NFITVIePSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLTHLDLRGNQLQTLPYVGFLEHIgRILDL 213
Cdd:COG4886 192 NQITDL-PEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNL-EELDL 257
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
68-219 3.76e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.44  E-value: 3.76e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40217825  68 QLSLLNNGLTMLHTnDFSGLTNAISIHLGFNNIADIEiGAFNGLGLLKQLHINHNSLEILKEdTFHGLENLEFLQADNNF 147
Cdd:COG4886 140 ELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQ 216

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 40217825 148 ITVIePSAFSKLNRLKVLILNDNAIESLPpNIFRFVPLTHLDLRGNQLQTLPyvgFLEHIGRILDLQLEDNK 219
Cdd:COG4886 217 LTDL-PEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLP---PLANLTNLKTLDLSNNQ 283
LRR_8 pfam13855
Leucine rich repeat;
411-471 1.14e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 66.01  E-value: 1.14e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 40217825   411 TRLQKLYLNGNHLTKLSKGMFLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNLL 471
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
366-616 2.80e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.66  E-value: 2.80e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40217825 366 RKLILAGNIIHSLmKSDLVEYFTLEMLHLGNNRIEVLEEgSFMNLTRLQKLYLNGNHLTKLSKGmFLGLHNLEYLYLEYN 445
Cdd:COG4886 162 KSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNN 238

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40217825 446 AIKEiLPGTFNpMPKLKVLYLNNNLLQVLPPhIFSGVPLTKVNLKTNQFTHLPVSNiLDDLDLLTQIDLEDNPWDCSCDL 525
Cdd:COG4886 239 QLTD-LPELGN-LTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQLTDLKLKE-LELLLGLNSLLLLLLLLNLLELL 314

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40217825 526 VGLQQWIQKLSKNTVTDDILCTSPGHLDKKELKALNSEILCPGLVNNPSMPTQTSYLMVTTPATTTNTADTILRSLTDAV 605
Cdd:COG4886 315 ILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLL 394

                       250
                ....*....|.
gi 40217825 606 PLSVLILGLLI 616
Cdd:COG4886 395 TTTAGVLLLTL 405
LRR_8 pfam13855
Leucine rich repeat;
388-447 3.20e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 64.85  E-value: 3.20e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 40217825   388 TLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSKGMFLGLHNLEYLYLEYNAI 447
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 345-518 5.12e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 65.96  E-value: 5.12e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40217825 345 IHCQERNIESLSDLRPPPqNPRKLILAGNIIHSLmkSDLVEYFTLEMLHLGNNRIEVLEegSFMNLTRLQKLYLNGNHLT 424
Cdd:cd21340   7 LYLNDKNITKIDNLSLCK-NLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNRIS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40217825 425 KLSkGmFLGLHNLEYLYLEYNAIKEILPGTFNPM------PKLKVLYLNNNLLQVLPPhIFSGVPLTKVNLKTNQFTHL- 497
Cdd:cd21340  82 VVE-G-LENLTNLEELHIENQRLPPGEKLTFDPRslaalsNSLRVLNISGNNIDSLEP-LAPLRNLEQLDASNNQISDLe 158

                       170       180
                ....*....|....*....|.
gi 40217825 498 PVSNILDDLDLLTQIDLEDNP 518
Cdd:cd21340 159 ELLDLLSSWPSLRELDLTGNP 179
LRR_8 pfam13855
Leucine rich repeat;
137-195 4.19e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.30  E-value: 4.19e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 40217825   137 NLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVP-LTHLDLRGNQL 195
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPsLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
92-146 4.72e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.91  E-value: 4.72e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 40217825    92 SIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEFLQADNN 146
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
394-518 1.71e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 57.64  E-value: 1.71e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40217825 394 LGNNRIEVLEEGSFMNLTRLQKLYLNGNhltklskGMFLGLHNLEYLYLEYNAIKEiLPGTFNPMPKLKVLYLNNNLLQV 473
Cdd:COG4886  79 LLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTD-LPEELANLTNLKELDLSNNQLTD 150

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 40217825 474 LPPHIFSGVPLTKVNLKTNQFTHLPVSniLDDLDLLTQIDLEDNP 518
Cdd:COG4886 151 LPEPLGNLTNLKSLDLSNNQLTDLPEE--LGNLTNLKELDLSNNQ 193
LRR_8 pfam13855
Leucine rich repeat;
114-172 2.94e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.99  E-value: 2.94e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 40217825   114 LKQLHINHNSLEILKEDTFHGLENLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNAI 172
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
436-494 7.76e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.83  E-value: 7.76e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 40217825   436 NLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGVP-LTKVNLKTNQF 494
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPsLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
95-545 1.90e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 54.17  E-value: 1.90e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40217825  95 LGFNNIADIEIGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEFLQADNNfitviepSAFSKLNRLKVLILNDNAIES 174
Cdd:COG4886  55 LLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTD 127

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40217825 175 LPPNIFRFVPLTHLDLRGNQLQTLP-YVGFLEHIgRILDLQlednkwacNCDLLQLKTWLENmppqsiigdvvcnsppff 253
Cdd:COG4886 128 LPEELANLTNLKELDLSNNQLTDLPePLGNLTNL-KSLDLS--------NNQLTDLPEELGN------------------ 180

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40217825 254 kgsiLSRLKkesicptppvyeehedpsgSLHLaatssiNDSRMSTkttsilklptkapglipyitkpstqLPGPycpipc 333
Cdd:COG4886 181 ----LTNLK-------------------ELDL------SNNQITD-------------------------LPEP------ 200

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40217825 334 nckvlspsgllihcqernIESLSDLrpppqnpRKLILAGNIIHSLMKSdLVEYFTLEMLHLGNNRIEVLEEgsFMNLTRL 413
Cdd:COG4886 201 ------------------LGNLTNL-------EELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTDLPE--LGNLTNL 252

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40217825 414 QKLYLNGNHLTKLSKgmFLGLHNLEYLYLEYNAIKEI-------LPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGVPLTK 486
Cdd:COG4886 253 EELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLklkelelLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLL 330

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 40217825 487 VNLKTNQFTHLPVSNILDDLDLLTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVTDDIL 545
Cdd:COG4886 331 KGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTL 389
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
69-219 6.15e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 52.63  E-value: 6.15e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40217825  69 LSLLNNGLTMLHtNDFSGLTNAISIHLGFNNIADIEiGAFNGLGLLKQLHINHNSLEILKEdtFHGLENLEFLQADNNFI 148
Cdd:COG4886 187 LDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQL 262

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 40217825 149 TVIEPSAfsKLNRLKVLILNDNAIESLPPNIFRFVPLTHLDLRGNQLQTLPYVGFLEHIGRILDLQLEDNK 219
Cdd:COG4886 263 TDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLK 331
LRRCT smart00082
Leucine rich repeat C-terminal domain;
517-567 8.12e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 46.65  E-value: 8.12e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 40217825    517 NPWDCSCDLVGLQQWIQKLSKNTVTDDILCTSPGHLDKKELKALNSEILCP 567
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGPLLELLHSEFKCP 51
LRR_8 pfam13855
Leucine rich repeat;
459-518 8.51e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.05  E-value: 8.51e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 40217825   459 PKLKVLYLNNNLLQVLPPHIFSGVP-LTKVNLKTNQFTHLPvSNILDDLDLLTQIDLEDNP 518
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSnLKVLDLSNNLLTTLS-PGAFSGLPSLRYLDLSGNR 60
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 68-199 8.53e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.86  E-value: 8.53e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40217825  68 QLSLLNNGLTMLhtNDFSGLTNAISIHLGFNNIADIEigAFNGLGLLKQLHINHNSLE-----ILKEDTFHGL-ENLEFL 141
Cdd:cd21340  50 HLYLQNNQIEKI--ENLENLVNLKKLYLGGNRISVVE--GLENLTNLEELHIENQRLPpgeklTFDPRSLAALsNSLRVL 125

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 40217825 142 QADNNFITVIEPsaFSKLNRLKVLILNDNAIESLP---PNIFRFVPLTHLDLRGNQLQTLP 199
Cdd:cd21340 126 NISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEellDLLSSWPSLRELDLTGNPVCKKP 184
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 88-193 3.53e-05

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 44.07  E-value: 3.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40217825    88 TNAISIHLGfNNIADIEIGAFNGLGLLKQLHINhNSLEILKEDTFHG--LENLEFlqadNNFITVIEPSAFSKLNRLKVL 165
Cdd:pfam13306  11 CSLTSITIP-SSLTSIGEYAFSNCTSLKSITLP-SSLTSIGSYAFYNcsLTSITI----PSSLTSIGEYAFSNCSNLKSI 84

                          90       100
                  ....*....|....*....|....*...
gi 40217825   166 ILNDNaIESLPPNIFRFVPLTHLDLRGN 193
Cdd:pfam13306  85 TLPSN-LTSIGSYAFSNCSLKSITIPSS 111
LRR_8 pfam13855
Leucine rich repeat;
69-124 6.50e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 6.50e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 40217825    69 LSLLNNGLTMLHTNDFSGLTNAISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSL 124
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 69-219 1.30e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.01  E-value: 1.30e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40217825  69 LSLLNNGLTMLhtNDFSGLTNAISIHLGFNNIADIEigAFNGLGLLKQLHINHNSLEILkeDTFHGLENLEFLQADNNFI 148
Cdd:cd21340   7 LYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40217825 149 TVIEpsAFSKLNRLKVLILNDNAIEslPPNIFRFVP---------LTHLDLRGNQLQTLPYVGFLEHIgRILDlqLEDNK 219
Cdd:cd21340  81 SVVE--GLENLTNLEELHIENQRLP--PGEKLTFDPrslaalsnsLRVLNISGNNIDSLEPLAPLRNL-EQLD--ASNNQ 153
LRRCT smart00082
Leucine rich repeat C-terminal domain;
218-268 1.62e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 40.11  E-value: 1.62e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 40217825    218 NKWACNCDLLQLKTWLEN--MPPQSiiGDVVCNSPPFFKGSILSRLKKESICP 268
Cdd:smart00082   1 NPFICDCELRWLLRWLQAneHLQDP--VDLRCASPSSLRGPLLELLHSEFKCP 51
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 69-494 3.10e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.45  E-value: 3.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40217825   69 LSLLNNGLTMLHTNDFSGLTNAISIHLGFNNIAD---IEIGafnGLGLLKQLHINHNSLEILKEDTFHGLENLEFL-QAD 144
Cdd:PLN00113 193 LTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGeipYEIG---GLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLfLYQ 269

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40217825  145 NNFITVIEPSAFSkLNRLKVLILNDNAIE-SLPPNIFRFVPLTHLDLRGNQLQ-TLPyvGFLEHIGRILDLQLEDNKWAC 222
Cdd:PLN00113 270 NKLSGPIPPSIFS-LQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFTgKIP--VALTSLPRLQVLQLWSNKFSG 346

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40217825  223 ----------NCDLLQLKTwlENMPPQsiIGDVVCNSPPFFKGSILSRLKKESICPTppvyeehedpsgslhLAATSSIN 292
Cdd:PLN00113 347 eipknlgkhnNLTVLDLST--NNLTGE--IPEGLCSSGNLFKLILFSNSLEGEIPKS---------------LGACRSLR 407

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40217825  293 DSRMSTKTTSiLKLP---TKAPgLIPYITKPSTQLPGpycpipcnckvlspsgllihcqerNIESLSDLRPPPQnprKLI 369
Cdd:PLN00113 408 RVRLQDNSFS-GELPsefTKLP-LVYFLDISNNNLQG------------------------RINSRKWDMPSLQ---MLS 458

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40217825  370 LAGNIIHSLMkSDLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSKGMFLGLHNLEYLYLEYNAIKE 449
Cdd:PLN00113 459 LARNKFFGGL-PDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSG 537

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*.
gi 40217825  450 ILPGTFNPMPKLKVLYLNNNLLQ-VLPPHIFSGVPLTKVNLKTNQF 494
Cdd:PLN00113 538 QIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISHNHL 583
LRR_8 pfam13855
Leucine rich repeat;
161-219 9.52e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.27  E-value: 9.52e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 40217825   161 RLKVLILNDNAIESLPPNIFRFVP-LTHLDLRGNQLQTLPYVGFlEHIGRILDLQLEDNK 219
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSnLKVLDLSNNLLTTLSPGAF-SGLPSLRYLDLSGNR 60
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 410-474 2.74e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.15  E-value: 2.74e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40217825 410 LTRLQKLYLNGNHLTK-------------------LSKGMFLG-LHNLEYLYLEYNAIKEILPgtFNPMPKLKVLYLNNN 469
Cdd:cd21340   1 LKRITHLYLNDKNITKidnlslcknlkvlylydnkITKIENLEfLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGN 78


                ....*
gi 40217825 470 LLQVL 474
Cdd:cd21340  79 RISVV 83
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 397-489 4.96e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 37.91  E-value: 4.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40217825   397 NRIEVLEEGSFMNLTRLQKLYLNGNhLTKLSKGMFLGLhNLEYLYLEyNAIKEILPGTFNPMPKLKVLYLNNNlLQVLPP 476
Cdd:pfam13306  20 SSLTSIGEYAFSNCTSLKSITLPSS-LTSIGSYAFYNC-SLTSITIP-SSLTSIGEYAFSNCSNLKSITLPSN-LTSIGS 95

                          90
                  ....*....|...
gi 40217825   477 HIFSGVPLTKVNL 489
Cdd:pfam13306  96 YAFSNCSLKSITI 108
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 389-495 7.84e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.83  E-value: 7.84e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40217825  389 LEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSKGMFLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYL-N 467
Cdd:PLN00113 262 LQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLwS 341

                         90       100
                 ....*....|....*....|....*...
gi 40217825  468 NNLLQVLPPHIFSGVPLTKVNLKTNQFT 495
Cdd:PLN00113 342 NKFSGEIPKNLGKHNNLTVLDLSTNNLT 369
LRR smart00370
Leucine-rich repeats, outliers;
458-481 8.32e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 34.63  E-value: 8.32e-03
                           10        20
                   ....*....|....*....|....
gi 40217825    458 MPKLKVLYLNNNLLQVLPPHIFSG 481
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
458-481 8.32e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 34.63  E-value: 8.32e-03
                           10        20
                   ....*....|....*....|....
gi 40217825    458 MPKLKVLYLNNNLLQVLPPHIFSG 481
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 411-445 9.43e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.91  E-value: 9.43e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 40217825   411 TRLQKLYLNGNHLTKLSkgMFLGLHNLEYLYLEYN 445
Cdd:pfam12799   1 PNLEVLDLSNNQITDIP--PLAKLPNLETLDLSGN 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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