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Conserved domains on  [gi|608601818|ref|NP_115850|]
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sperm protein associated with the nucleus on the X chromosome B1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SPAN-X super family cl06478
Sperm protein associated with nucleus, mapped to X chromosome; This family contains human ...
 1-88 4.61e-27

Sperm protein associated with nucleus, mapped to X chromosome; This family contains human sperm proteins associated with the nucleus and mapped to the X chromosome (SPAN-X) (approximately 100 residues long). SPAN-X proteins are cancer-testis antigens (CTAs), and thus represent potential targets for cancer immunotherapy because they are widely distributed in tumours but not in normal tissues, except testes. They are highly insoluble, acidic, and polymorphic.


The actual alignment was detected with superfamily member pfam07458:

Pssm-ID: 400025  Cd Length: 94  Bit Score: 95.00  E-value: 4.61e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608601818    1 MGQ-QSSVRRLKRSVPCESNEANeaneanKTMPETPTGDSDPQPAPKKMKTSESSTILVVRYRRNVKRtSPEELLNDHAR 79
Cdd:pfam07458   1 MEQpTSSTNGEKRKSPCDSNNAN------DEMQETPNRDLAPQPSLKKTKTSEYSTILVVRYRKNKKI-SSNQLENDQSR 73


                  ....*....
gi 608601818   80 ENRINPDQM 88
Cdd:pfam07458  74 ENSINPLQM 82
 
Name Accession Description Interval E-value
SPAN-X pfam07458
Sperm protein associated with nucleus, mapped to X chromosome; This family contains human ...
 1-88 4.61e-27

Sperm protein associated with nucleus, mapped to X chromosome; This family contains human sperm proteins associated with the nucleus and mapped to the X chromosome (SPAN-X) (approximately 100 residues long). SPAN-X proteins are cancer-testis antigens (CTAs), and thus represent potential targets for cancer immunotherapy because they are widely distributed in tumours but not in normal tissues, except testes. They are highly insoluble, acidic, and polymorphic.


Pssm-ID: 400025  Cd Length: 94  Bit Score: 95.00  E-value: 4.61e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608601818    1 MGQ-QSSVRRLKRSVPCESNEANeaneanKTMPETPTGDSDPQPAPKKMKTSESSTILVVRYRRNVKRtSPEELLNDHAR 79
Cdd:pfam07458   1 MEQpTSSTNGEKRKSPCDSNNAN------DEMQETPNRDLAPQPSLKKTKTSEYSTILVVRYRKNKKI-SSNQLENDQSR 73


                  ....*....
gi 608601818   80 ENRINPDQM 88
Cdd:pfam07458  74 ENSINPLQM 82
 
Name Accession Description Interval E-value
SPAN-X pfam07458
Sperm protein associated with nucleus, mapped to X chromosome; This family contains human ...
 1-88 4.61e-27

Sperm protein associated with nucleus, mapped to X chromosome; This family contains human sperm proteins associated with the nucleus and mapped to the X chromosome (SPAN-X) (approximately 100 residues long). SPAN-X proteins are cancer-testis antigens (CTAs), and thus represent potential targets for cancer immunotherapy because they are widely distributed in tumours but not in normal tissues, except testes. They are highly insoluble, acidic, and polymorphic.


Pssm-ID: 400025  Cd Length: 94  Bit Score: 95.00  E-value: 4.61e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608601818    1 MGQ-QSSVRRLKRSVPCESNEANeaneanKTMPETPTGDSDPQPAPKKMKTSESSTILVVRYRRNVKRtSPEELLNDHAR 79
Cdd:pfam07458   1 MEQpTSSTNGEKRKSPCDSNNAN------DEMQETPNRDLAPQPSLKKTKTSEYSTILVVRYRKNKKI-SSNQLENDQSR 73


                  ....*....
gi 608601818   80 ENRINPDQM 88
Cdd:pfam07458  74 ENSINPLQM 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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