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Conserved domains on  [gi|40255005|ref|NP_116201|]
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plexin domain-containing protein 2 isoform 1 precursor [Homo sapiens]

Protein Classification

NIDO and PSI domain-containing protein( domain architecture ID 10250010)

NIDO and PSI domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
327-372 1.04e-08

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas shows 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


:

Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 51.17  E-value: 1.04e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 40255005   327 TCLQFNRCGPCVSSQiGFNCSWCSKLQRCS-----SGFDRHRQDWVD--SGCP 372
Cdd:pfam01437   1 RCSQYTSCSSCLAAR-DPYCGWCSSEGRCVrrsacGAPEGNCEEWEQasSKCP 52
NIDO super family cl02648
Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found ...
191-282 2.07e-03

Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found in nidogen and hypothetical proteins of unknown function.


The actual alignment was detected with superfamily member smart00539:

Pssm-ID: 445871  Cd Length: 152  Bit Score: 38.95  E-value: 2.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255005    191 RMLTATQYIAPLMANFDPsvsrnstvryfdnGTALVVQWDHV-HLQDNYNLGSFTFQATLLMDGR---IIFGYKEIP--V 264
Cdd:smart00539  27 RATESVREGFTDMGGFRA-------------KSVVIVTWENVaAYGSQSSDGTNTFQAVLATDGSrtyAIFLYPSLGwtS 93
                           90
                   ....*....|....*...
gi 40255005    265 LVTQISSTNHPVKVGLSD 282
Cdd:smart00539  94 DTTAGGDDGVRARAGFNG 111
 
Name Accession Description Interval E-value
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
327-372 1.04e-08

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas shows 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 51.17  E-value: 1.04e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 40255005   327 TCLQFNRCGPCVSSQiGFNCSWCSKLQRCS-----SGFDRHRQDWVD--SGCP 372
Cdd:pfam01437   1 RCSQYTSCSSCLAAR-DPYCGWCSSEGRCVrrsacGAPEGNCEEWEQasSKCP 52
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
328-372 5.22e-08

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 49.08  E-value: 5.22e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 40255005    328 CLQFNRCGPCVSSQiGFNCSWCSKLQRCSSGF--DRHRQDWVDSGCP 372
Cdd:smart00423   2 CSKYTSCSECLLAR-DPYCAWCSSQGRCTSGErcDSRRQNWLSGGCP 47
NIDO smart00539
Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;
191-282 2.07e-03

Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;


Pssm-ID: 214712  Cd Length: 152  Bit Score: 38.95  E-value: 2.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255005    191 RMLTATQYIAPLMANFDPsvsrnstvryfdnGTALVVQWDHV-HLQDNYNLGSFTFQATLLMDGR---IIFGYKEIP--V 264
Cdd:smart00539  27 RATESVREGFTDMGGFRA-------------KSVVIVTWENVaAYGSQSSDGTNTFQAVLATDGSrtyAIFLYPSLGwtS 93
                           90
                   ....*....|....*...
gi 40255005    265 LVTQISSTNHPVKVGLSD 282
Cdd:smart00539  94 DTTAGGDDGVRARAGFNG 111
 
Name Accession Description Interval E-value
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
327-372 1.04e-08

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas shows 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 51.17  E-value: 1.04e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 40255005   327 TCLQFNRCGPCVSSQiGFNCSWCSKLQRCS-----SGFDRHRQDWVD--SGCP 372
Cdd:pfam01437   1 RCSQYTSCSSCLAAR-DPYCGWCSSEGRCVrrsacGAPEGNCEEWEQasSKCP 52
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
328-372 5.22e-08

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 49.08  E-value: 5.22e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 40255005    328 CLQFNRCGPCVSSQiGFNCSWCSKLQRCSSGF--DRHRQDWVDSGCP 372
Cdd:smart00423   2 CSKYTSCSECLLAR-DPYCAWCSSQGRCTSGErcDSRRQNWLSGGCP 47
NIDO smart00539
Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;
191-282 2.07e-03

Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;


Pssm-ID: 214712  Cd Length: 152  Bit Score: 38.95  E-value: 2.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255005    191 RMLTATQYIAPLMANFDPsvsrnstvryfdnGTALVVQWDHV-HLQDNYNLGSFTFQATLLMDGR---IIFGYKEIP--V 264
Cdd:smart00539  27 RATESVREGFTDMGGFRA-------------KSVVIVTWENVaAYGSQSSDGTNTFQAVLATDGSrtyAIFLYPSLGwtS 93
                           90
                   ....*....|....*...
gi 40255005    265 LVTQISSTNHPVKVGLSD 282
Cdd:smart00539  94 DTTAGGDDGVRARAGFNG 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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