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Conserved domains on  [gi|67906814|ref|NP_116289|]
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rho GTPase-activating protein 19 isoform 1 [Homo sapiens]

Protein Classification

Rho GTPase-activating protein( domain architecture ID 10138218)

Rho GTPase-activating protein for Rho/Rac/Cdc42-like small GTPases that act as molecular switches, active in their GTP-bound form but inactive when bound to GDP; similar to mammalian rho GTPase-activating protein 19 (ARHGAP19), which participates in various cytoskeletal-related events, including epithelial morphogenesis

CATH:  1.10.555.10
Gene Ontology:  GO:0007165|GO:0005096
PubMed:  17222083|12480336

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RhoGAP_ARHGAP19 cd04392
RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 113-320 1.12e-125

RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


:

Pssm-ID: 239857  Cd Length: 208  Bit Score: 364.48  E-value: 1.12e-125
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 113 FGSPLTEEGIAQIYQLIEYLHKNLRVEGLFRVPGNSVRQQILRDALNNGTDIDLESGEFHSNDVATLLKMFLGELPEPLL 192
Cdd:cd04392   1 FGAPLTEEGIAQIYQLIEYLEKNLRVEGLFRKPGNSARQQELRDLLNSGTDLDLESGGFHAHDCATVLKGFLGELPEPLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 193 THKHFNAHLKIADLMQFDDKGNKTNIPDKDRQIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKNKMSAYNLALMFA 272
Cdd:cd04392  81 THAHYPAHLQIADLCQFDEKGNKTSAPDKERLLEALQLLLLLLPEENRNLLKLILDLLYQTAKHEDKNKMSADNLALLFT 160

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 67906814 273 PHVLWPKNVTANDLQENITKLNSGMAFMIKHSQKLFKAPAYIRECARL 320
Cdd:cd04392 161 PHLICPRNLTPEDLHENAQKLNSIVTFMIKHSQKLFKAPAYLREDARA 208
 
Name Accession Description Interval E-value
RhoGAP_ARHGAP19 cd04392
RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 113-320 1.12e-125

RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239857  Cd Length: 208  Bit Score: 364.48  E-value: 1.12e-125
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 113 FGSPLTEEGIAQIYQLIEYLHKNLRVEGLFRVPGNSVRQQILRDALNNGTDIDLESGEFHSNDVATLLKMFLGELPEPLL 192
Cdd:cd04392   1 FGAPLTEEGIAQIYQLIEYLEKNLRVEGLFRKPGNSARQQELRDLLNSGTDLDLESGGFHAHDCATVLKGFLGELPEPLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 193 THKHFNAHLKIADLMQFDDKGNKTNIPDKDRQIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKNKMSAYNLALMFA 272
Cdd:cd04392  81 THAHYPAHLQIADLCQFDEKGNKTSAPDKERLLEALQLLLLLLPEENRNLLKLILDLLYQTAKHEDKNKMSADNLALLFT 160

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 67906814 273 PHVLWPKNVTANDLQENITKLNSGMAFMIKHSQKLFKAPAYIRECARL 320
Cdd:cd04392 161 PHLICPRNLTPEDLHENAQKLNSIVTFMIKHSQKLFKAPAYLREDARA 208
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 125-304 2.44e-37

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 135.09  E-value: 2.44e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814    125 IYQLIEYLHKN-LRVEGLFRVPGNSVRQQILRDALNNGTDIDLESGEFHSNDVATLLKMFLGELPEPLLTHKHFNAHLKI 203
Cdd:smart00324   7 VEKCIEYLEKRgLDTEGIYRVSGSKSRVKELRDAFDSGPDPDLDLSEYDVHDVAGLLKLFLRELPEPLITYELYEEFIEA 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814    204 AdlmqfddkgnktNIPDKDRQIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKNKMSAYNLALMFAPHVLWPKNVTA 283
Cdd:smart00324  87 A------------KLEDETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLLRPPDGEV 154

                          170       180
                   ....*....|....*....|.
gi 67906814    284 NDLQEnITKLNSGMAFMIKHS 304
Cdd:smart00324 155 ASLKD-IRHQNTVIEFLIENA 174
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 125-280 3.25e-36

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 131.13  E-value: 3.25e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814   125 IYQLIEYLHKN-LRVEGLFRVPGNSVRQQILRDALNNGTDIDLESGEFHSNDVATLLKMFLGELPEPLLTHKHFNAHLKI 203
Cdd:pfam00620   4 VRKCVEYLEKRgLDTEGIFRVSGSASRIKELREAFDRGPDVDLDLEEEDVHVVASLLKLFLRELPEPLLTFELYEEFIEA 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 67906814   204 ADlmqfddkgnktnIPDKDRQIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKNKMSAYNLALMFAPHVLWPKN 280
Cdd:pfam00620  84 AK------------LPDEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPPD 148
 
Name Accession Description Interval E-value
RhoGAP_ARHGAP19 cd04392
RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 113-320 1.12e-125

RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239857  Cd Length: 208  Bit Score: 364.48  E-value: 1.12e-125
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 113 FGSPLTEEGIAQIYQLIEYLHKNLRVEGLFRVPGNSVRQQILRDALNNGTDIDLESGEFHSNDVATLLKMFLGELPEPLL 192
Cdd:cd04392   1 FGAPLTEEGIAQIYQLIEYLEKNLRVEGLFRKPGNSARQQELRDLLNSGTDLDLESGGFHAHDCATVLKGFLGELPEPLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 193 THKHFNAHLKIADLMQFDDKGNKTNIPDKDRQIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKNKMSAYNLALMFA 272
Cdd:cd04392  81 THAHYPAHLQIADLCQFDEKGNKTSAPDKERLLEALQLLLLLLPEENRNLLKLILDLLYQTAKHEDKNKMSADNLALLFT 160

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 67906814 273 PHVLWPKNVTANDLQENITKLNSGMAFMIKHSQKLFKAPAYIRECARL 320
Cdd:cd04392 161 PHLICPRNLTPEDLHENAQKLNSIVTFMIKHSQKLFKAPAYLREDARA 208
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 125-304 2.44e-37

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 135.09  E-value: 2.44e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814    125 IYQLIEYLHKN-LRVEGLFRVPGNSVRQQILRDALNNGTDIDLESGEFHSNDVATLLKMFLGELPEPLLTHKHFNAHLKI 203
Cdd:smart00324   7 VEKCIEYLEKRgLDTEGIYRVSGSKSRVKELRDAFDSGPDPDLDLSEYDVHDVAGLLKLFLRELPEPLITYELYEEFIEA 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814    204 AdlmqfddkgnktNIPDKDRQIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKNKMSAYNLALMFAPHVLWPKNVTA 283
Cdd:smart00324  87 A------------KLEDETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLLRPPDGEV 154

                          170       180
                   ....*....|....*....|.
gi 67906814    284 NDLQEnITKLNSGMAFMIKHS 304
Cdd:smart00324 155 ASLKD-IRHQNTVIEFLIENA 174
RhoGAP cd00159
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 125-303 1.19e-36

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


Pssm-ID: 238090 [Multi-domain]  Cd Length: 169  Bit Score: 133.20  E-value: 1.19e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 125 IYQLIEYLHKN-LRVEGLFRVPGNSVRQQILRDALNNGTDIDLESgEFHSNDVATLLKMFLGELPEPLLTHKHFNAHLKI 203
Cdd:cd00159   4 IEKCIEYLEKNgLNTEGIFRVSGSASKIEELKKKFDRGEDIDDLE-DYDVHDVASLLKLYLRELPEPLIPFELYDEFIEL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 204 AdlmqfddkgnktNIPDKDRQIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKNKMSAYNLALMFAPHVLWPKNVTA 283
Cdd:cd00159  83 A------------KIEDEEERIEALKELLKSLPPENRDLLKYLLKLLHKISQNSEVNKMTASNLAIVFAPTLLRPPDSDD 150

                       170       180
                ....*....|....*....|
gi 67906814 284 NDLqENITKLNSGMAFMIKH 303
Cdd:cd00159 151 ELL-EDIKKLNEIVEFLIEN 169
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 125-280 3.25e-36

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 131.13  E-value: 3.25e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814   125 IYQLIEYLHKN-LRVEGLFRVPGNSVRQQILRDALNNGTDIDLESGEFHSNDVATLLKMFLGELPEPLLTHKHFNAHLKI 203
Cdd:pfam00620   4 VRKCVEYLEKRgLDTEGIFRVSGSASRIKELREAFDRGPDVDLDLEEEDVHVVASLLKLFLRELPEPLLTFELYEEFIEA 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 67906814   204 ADlmqfddkgnktnIPDKDRQIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKNKMSAYNLALMFAPHVLWPKN 280
Cdd:pfam00620  84 AK------------LPDEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPPD 148
RhoGAP_ARHGAP18 cd04391
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 112-314 1.19e-26

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239856  Cd Length: 216  Bit Score: 107.05  E-value: 1.19e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 112 IFGSPLT-----------EEGIAQIYQ-LIEYLHKN-LRVEGLFRVPGNSVRQQILRDALN---NGTDIDLESgeFHSND 175
Cdd:cd04391   1 LFGVPLStllerdqkkvpGSKVPLIFQkLINKLEERgLETEGILRIPGSAQRVKFLCQELEakfYEGTFLWDQ--VKQHD 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 176 VATLLKMFLGELPEPLLTHKHFNAHLKIadlmqfddkgnkTNIPDKDRQIEALQLLFLILPPPNRNLLKLLLDLLYQTAK 255
Cdd:cd04391  79 AASLLKLFIRELPQPLLTVEYLPAFYSV------------QGLPSKKDQLQALNLLVLLLPEANRDTLKALLEFLQKVVD 146

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 67906814 256 KQDKNKMSAYNLALMFAPHVLWPKNVTANDLQENITKLNSG------MAFMIKHSQKLFKAPAYI 314
Cdd:cd04391 147 HEEKNKMNLWNVAMIMAPNLFPPRGKHSKDNESLQEEVNMAagcaniMRLLIRYQDLLWTVPSFL 211
RhoGAP_nadrin cd04386
RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 112-308 2.42e-22

RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in tight junction maintenance in mammalian epithelium. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239851  Cd Length: 203  Bit Score: 94.83  E-value: 2.42e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 112 IFGSPL------TEEGIAQIYQL-IEYLHKN-LRVEGLFRVPGNSVRQQILRDALNNGTdIDLESGEFHSND--VATLLK 181
Cdd:cd04386   4 VFGTPLeehlkrTGREIALPIEAcVMCLLETgMNEEGLFRVGGGASKLKRLKAALDAGT-FSLPLDEFYSDPhaVASALK 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 182 MFLGELPEPLLTHKHFNAHLKIAdlmqfddkgnktNIPDKDRQIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKNK 261
Cdd:cd04386  83 SYLRELPDPLLTYNLYEDWVQAA------------NKPDEDERLQAIWRILNKLPRENRDNLRYLIKFLSKLAQKSDENK 150

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 67906814 262 MSAYNLALMFAPHVLWPKNVTANDLQE--NITKLNSGMAFMIKHSQKLF 308
Cdd:cd04386 151 MSPSNIAIVLAPNLLWAKNEGSLAEMAagTSVHVVAIVELIISHADWFF 199
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 124-314 4.32e-22

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239841  Cd Length: 206  Bit Score: 94.04  E-value: 4.32e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 124 QIYQLIE----YLHKN-LRVEGLFRVPGNSVRQQILRDALNNGTDIDLESgEFHSNDVATLLKMFLGELPEPLLTHKHFN 198
Cdd:cd04376   8 QVPRLVEsccqHLEKHgLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLDE-NHSVHDVAALLKEFFRDMPDPLLPRELYT 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 199 AHLKIADLmqfddkgnktnipDKDRQIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDK-----------NKMSAYNL 267
Cdd:cd04376  87 AFIGTALL-------------EPDEQLEALQLLIYLLPPCNCDTLHRLLKFLHTVAEHAADsidedgqevsgNKMTSLNL 153

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 67906814 268 ALMFAPHVL-------WPKNVTANDLQENITKLNSGMAfMIKHSQKLFKAPAYI 314
Cdd:cd04376 154 ATIFGPNLLhkqksgeREFVQASLRIEESTAIINVVQT-MIDNYEELFMVSPEL 206
RhoGAP-ARHGAP11A cd04394
RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 112-276 1.34e-21

RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing a role in retinal development. The exact function of ArhGAP11A is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239859 [Multi-domain]  Cd Length: 202  Bit Score: 92.54  E-value: 1.34e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 112 IFGSPL--------TEEG-IAQI-YQLIEYLHKNLRVEGLFRVPGNSVRQQILRDALNNGTDIDlesGEFHSNDVATLLK 181
Cdd:cd04394   1 VFGVPLhslphstvPEYGnVPKFlVDACTFLLDHLSTEGLFRKSGSVVRQKELKAKLEGGEACL---SSALPCDVAGLLK 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 182 MFLGELPEPLLTHKHFNAHLKIADLmqfddkgnktniPDKDRQIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKNK 261
Cdd:cd04394  78 QFFRELPEPLLPYDLHEALLKAQEL------------PTDEERKSATLLLTCLLPDEHVNTLRYFFSFLYDVAQRCSENK 145

                       170
                ....*....|....*
gi 67906814 262 MSAYNLALMFAPHVL 276
Cdd:cd04394 146 MDSSNLAVIFAPNLF 160
RhoGAP-p50rhoGAP cd04404
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 113-308 3.42e-21

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239869 [Multi-domain]  Cd Length: 195  Bit Score: 91.25  E-value: 3.42e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 113 FGSPLT--------EEGIAQIY-QLIEYLHKN-LRVEGLFRVPGNSVRQQILRDALNNGTDIDLESgefhSNDV---ATL 179
Cdd:cd04404   6 FGVSLQflkeknpeQEPIPPVVrETVEYLQAHaLTTEGIFRRSANTQVVKEVQQKYNMGEPVDFDQ----YEDVhlpAVI 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 180 LKMFLGELPEPLLTHKHFNAHLKIADLmqfddkgnktnipDKDRQIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDK 259
Cdd:cd04404  82 LKTFLRELPEPLLTFDLYDDIVGFLNV-------------DKEERVERVKQLLQTLPEENYQVLKYLIKFLVQVSAHSDQ 148

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 67906814 260 NKMSAYNLALMFAPHVLWPKNVTANdlQENITKLNSGMAFMIKHSQKLF 308
Cdd:cd04404 149 NKMTNSNLAVVFGPNLLWAKDASMS--LSAINPINTFTKFLLDHQDEIF 195
RhoGAP_GMIP_PARG1 cd04378
RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 129-283 1.90e-19

RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein) and PARG1 (PTPL1-associated RhoGAP1). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239843  Cd Length: 203  Bit Score: 86.32  E-value: 1.90e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 129 IEylHKNLRVEGLFRVPGNSVRQQILRDALNNGTDIdLESGEFHSNDVATLLKMFLGELPEPLLTHKHFNAHLKIA-DLM 207
Cdd:cd04378  27 IE--NRALGVQGIYRVSGSKARVEKLCQAFENGKDL-VELSELSPHDISSVLKLFLRQLPEPLILFRLYNDFIALAkEIQ 103

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 67906814 208 QFDDKGNKTNIP-DKDRQIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKNKMSAYNLALMFAPHVLWPKNVTA 283
Cdd:cd04378 104 RDTEEDKAPNTPiEVNRIIRKLKDLLRQLPASNYNTLQHLIAHLYRVAEQFEENKMSPNNLGIVFGPTLIRPRPGDA 180
RhoGAP_myosin_IX cd04377
RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 127-302 4.39e-19

RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239842  Cd Length: 186  Bit Score: 84.80  E-value: 4.39e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 127 QLIEYLHKN-LRVEGLFRVPGNSVRQQILRDALNNGTD-IDLESGEFHSndVATLLKMFLGELPEPLLTHKHFNAHLKIA 204
Cdd:cd04377  21 KLLEHIEMHgLYTEGIYRKSGSANKIKELRQGLDTDPDsVNLEDYPIHV--ITSVLKQWLRELPEPLMTFELYENFLRAM 98

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 205 DLmqfddkgnktniPDKDRQIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKNKMSAYNLALMFAPHVL-WPKNVTA 283
Cdd:cd04377  99 EL------------EEKQERVRALYSVLEQLPRANLNTLERLIFHLVRVALQEEVNRMSANALAIVFAPCILrCPDTADP 166

                       170
                ....*....|....*....
gi 67906814 284 NDLQENITKLNSGMAFMIK 302
Cdd:cd04377 167 LQSLQDVSKTTTCVETLIK 185
RhoGAP_ARHGAP20 cd04402
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 139-308 2.03e-18

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239867  Cd Length: 192  Bit Score: 83.12  E-value: 2.03e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 139 EGLFRVPGNSVRQQILRDALNNGTDIDLESGEFHSndVATLLKMFLGELPEPLLTHKHFNAHLKIADLmqfddkgnktni 218
Cdd:cd04402  34 EGIFRRSANAKACKELKEKLNSGVEVDLKAEPVLL--LASVLKDFLRNIPGSLLSSDLYEEWMSALDQ------------ 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 219 PDKDRQIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKNKMSAYNLALMFAPHVLWPkNVTANDLQENITKLNSGMA 298
Cdd:cd04402 100 ENEEEKIAELQRLLDKLPRPNVLLLKHLICVLHNISQNSETNKMDAFNLAVCIAPSLLWP-PASSELQNEDLKKVTSLVQ 178

                       170
                ....*....|
gi 67906814 299 FMIKHSQKLF 308
Cdd:cd04402 179 FLIENCQEIF 188
RhoGAP_DLC1 cd04375
RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 112-313 2.39e-18

RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START (StAR-related lipid transfer action) domain. DLC1 has tumor suppressor activity in cell culture. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239840  Cd Length: 220  Bit Score: 83.62  E-value: 2.39e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 112 IFGSPL------TEEGIAQ-IYQLIEYLHKN-LRVEGLFRVPGNSVRQQILRDaLNNGTDIDLESGEFHSNDVATLLKMF 183
Cdd:cd04375   4 VFGVPLlvnlqrTGQPLPRsIQQAMRWLRNNaLDQVGLFRKSGVKSRIQKLRS-MIESSTDNVNYDGQQAYDVADMLKQY 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 184 LGELPEPLLTHKHFNAHLKIadlMQFddkgnktnIPDKDRqIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKNKMS 263
Cdd:cd04375  83 FRDLPEPLLTNKLSETFIAI---FQY--------VPKEQR-LEAVQCAILLLPDENREVLQTLLYFLSDVAANSQENQMT 150

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 67906814 264 AYNLALMFAP---HVLWPKNVTANDLQENITKLNSGM----------------AFMIKHSQKLFKAPAY 313
Cdd:cd04375 151 ATNLAVCLAPslfHLNTSRRENSSPARRMQRKKSLGKpdqkelsenkaahqclAYMIEECNTLFMVPKE 219
RhoGAP_ARHGAP27_15_12_9 cd04403
RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 134-284 6.09e-18

RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are studied show GAP activity towards Rac1, some additionally show activity towards Cdc42. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239868 [Multi-domain]  Cd Length: 187  Bit Score: 81.67  E-value: 6.09e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 134 KNLRVEGLFRVPGNSVRQQILRDALNNGTDIDLESGEFHSNDVAT-LLKMFLGELPEPLLTHKHFNahlkiadlmqfdDK 212
Cdd:cd04403  30 RGLDVDGIYRVSGNLAVIQKLRFAVDHDEKLDLDDSKWEDIHVITgALKLFFRELPEPLFPYSLFN------------DF 97

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 67906814 213 GNKTNIPDKDRQIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKNKMSAYNLALMFAPHVLWPKNVTAN 284
Cdd:cd04403  98 VAAIKLSDYEQRVSAVKDLIKSLPKPNHDTLKMLFRHLCRVIEHGEKNRMTTQNLAIVFGPTLLRPEQETGN 169
RhoGAP_PARG1 cd04409
RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 136-283 3.11e-17

RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of PARG1 (PTPL1-associated RhoGAP1). PARG1 was originally cloned as an interaction partner of PTPL1, an intracellular protein-tyrosine phosphatase. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239874  Cd Length: 211  Bit Score: 80.24  E-value: 3.11e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 136 LRVEGLFRVPGNSVRQQILRDALNNGTDIdLESGEFHSNDVATLLKMFLGELPEPLLTHKHFNAHLKIADLMQFDDKGNK 215
Cdd:cd04409  32 LCLKGIYRVNGAKSRVEKLCQAFENGKDL-VELSELSPHDISNVLKLYLRQLPEPLILFRLYNEFIGLAKESQHVNETQE 110

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 67906814 216 TNIPDKDRQ----IEALQLLFLI------LPPPNRNLLKLLLDLLYQTAKKQDKNKMSAYNLALMFAPHVLWPKNVTA 283
Cdd:cd04409 111 AKKNSDKKWpnmcTELNRILLKSkdllrqLPAPNYNTLQFLIVHLHRVSEQAEENKMSASNLGIIFGPTLIRPRPTDA 188
RhoGAP_fSAC7_BAG7 cd04396
RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 131-307 3.49e-17

RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal SAC7 and BAG7-like proteins. Both proteins are GTPase activating proteins of Rho1, but differ functionally in vivo: SAC7, but not BAG7, is involved in the control of Rho1-mediated activation of the PKC-MPK1 pathway. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239861  Cd Length: 225  Bit Score: 80.53  E-value: 3.49e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 131 YLHKN-LRVEGLFRVPGNSVRQQILRDALNNGTDI--DLESGEFHSNDVATLLKMFLGELPEPLLTHKHF----NAHLKI 203
Cdd:cd04396  42 YLKENaTEVEGIFRVAGSSKRIRELQLIFSTPPDYgkSFDWDGYTVHDAASVLRRYLNNLPEPLVPLDLYeefrNPLRKR 121

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 204 ADLMQFDDKGNKTNIP-DKDRQIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKNKMSAYNLALMFAPHVLwpkNVT 282
Cdd:cd04396 122 PRILQYMKGRINEPLNtDIDQAIKEYRDLITRLPNLNRQLLLYLLDLLAVFARNSDKNLMTASNLAAIFQPGIL---SHP 198

                       170       180
                ....*....|....*....|....*.
gi 67906814 283 ANDLQENITKLN-SGMAFMIKHSQKL 307
Cdd:cd04396 199 DHEMDPKEYKLSrLVVEFLIEHQDKF 224
RhoGAP_FAM13A1a cd04393
RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 112-275 2.62e-16

RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by up several orders of magnitude.


Pssm-ID: 239858 [Multi-domain]  Cd Length: 189  Bit Score: 77.12  E-value: 2.62e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 112 IFGSPL--------TEEGI-AQIYQLIEYLHKN-LRVEGLFRVPGNSVRQQILRDALNNGTDIDL-ESGEFHSndVATLL 180
Cdd:cd04393   2 VFGVPLqelqqagqPENGVpAVVRHIVEYLEQHgLEQEGLFRVNGNAETVEWLRQRLDSGEEVDLsKEADVCS--AASLL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 181 KMFLGELPEPLLthkhfNAHLKIAdLMQFDDKGNKtnipdKDRQIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKN 260
Cdd:cd04393  80 RLFLQELPEGLI-----PASLQIR-LMQLYQDYNG-----EDEFGRKLRDLLQQLPPVNYSLLKFLCHFLSNVASQHHEN 148

                       170
                ....*....|....*
gi 67906814 261 KMSAYNLALMFAPHV 275
Cdd:cd04393 149 RMTAENLAAVFGPDV 163
RhoGAP_fBEM3 cd04400
RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of ...
 112-291 2.72e-16

RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of fungal BEM3-like proteins. Bem3 is a GAP protein of Cdc42, and is specifically involved in the control of the initial assembly of the septin ring in yeast bud formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239865 [Multi-domain]  Cd Length: 190  Bit Score: 77.01  E-value: 2.72e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 112 IFGSPLTE-----------EGIAQI-YQLIEYLHKN--LRVEGLFRVPGNSVRQQILRDALNNGTDIDL-ESGEFHS-ND 175
Cdd:cd04400   1 IFGSPLEEavelsshkyngRDLPSVvYRCIEYLDKNraIYEEGIFRLSGSASVIKQLKERFNTEYDVDLfSSSLYPDvHT 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 176 VATLLKMFLGELPEPLLTHKHFNAHLKIADLMqfddkgnktniPDKDRQIEALQLLFLILPPPNRNLLKLLLDLLYQTAK 255
Cdd:cd04400  81 VAGLLKLYLRELPTLILGGELHNDFKRLVEEN-----------HDRSQRALELKDLVSQLPQANYDLLYVLFSFLRKIIE 149

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 67906814 256 KQDKNKMSAYNLALMFAPHVlwpkNVTANDLQENIT 291
Cdd:cd04400 150 HSDVNKMNLRNVCIVFSPTL----NIPAGIFVLFLT 181
RhoGAP_ARHGAP21 cd04395
RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 134-280 3.14e-16

RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction complex. It has been shown to function as a GAP of Cdc42 and RhoA, and to interact with alpha-catenin and Arf6. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239860  Cd Length: 196  Bit Score: 77.06  E-value: 3.14e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 134 KNLRVEGLFRVPGNSVRQQILRDALNNG-TDIDLESGEFHS-NDVATLLKMFLGELPEPLLTHKHFNAHLKiadlmqfdd 211
Cdd:cd04395  32 RGLETVGIYRVPGNNAAISALQEELNRGgFDIDLQDPRWRDvNVVSSLLKSFFRKLPEPLFTNELYPDFIE--------- 102

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 67906814 212 kGNKtnIPDKDRQIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKNKMSAYNLALMFAPHVLWPKN 280
Cdd:cd04395 103 -ANR--IEDPVERLKELRRLIHSLPDHHYETLKHLIRHLKTVADNSEVNKMEPRNLAIVFGPTLVRTSD 168
RhoGAP_myosin_IXB cd04407
RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 110-276 3.72e-16

RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239872 [Multi-domain]  Cd Length: 186  Bit Score: 76.57  E-value: 3.72e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 110 GVIFGSPLTEEGIAQIY--QLIEYLHKN-LRVEGLFRVPGNSVRQQILRDALNNG-TDIDLESGEFHSndVATLLKMFLG 185
Cdd:cd04407   2 GVRVGSLTSNKTSVPIVleKLLEHVEMHgLYTEGIYRKSGSANRMKELHQLLQADpENVKLENYPIHA--ITGLLKQWLR 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 186 ELPEPLLTHKHFNAHLKIADLmqfddkgnktniPDKDRQIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKNKMSAY 265
Cdd:cd04407  80 ELPEPLMTFAQYNDFLRAVEL------------PEKQEQLQAIYRVLEQLPTANHNTLERLIFHLVKVALEEDVNRMSPN 147

                       170
                ....*....|.
gi 67906814 266 NLALMFAPHVL 276
Cdd:cd04407 148 ALAIVFAPCLL 158
RhoGAP_fRGD1 cd04398
RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 113-273 1.58e-15

RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD1-like proteins. Yeast Rgd1 is a GAP protein for Rho3 and Rho4 and plays a role in low-pH response. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239863  Cd Length: 192  Bit Score: 74.75  E-value: 1.58e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 113 FGSPLTE----EGI---AQIYQLIEYLHK-NLRVEGLFRVPGNSVRQQILRDAL-NNGTDIDLESGEFHSND---VATLL 180
Cdd:cd04398   1 FGVPLEDlilrEGDnvpNIVYQCIQAIENfGLNLEGIYRLSGNVSRVNKLKELFdKDPLNVLLISPEDYESDihsVASLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 181 KMFLGELPEPLLTHKHFNAHLKIAdlmqfddkgnktNIPDKDRQIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKN 260
Cdd:cd04398  81 KLFFRELPEPLLTKALSREFIEAA------------KIEDESRRRDALHGLINDLPDANYATLRALMFHLARIKEHESVN 148

                       170
                ....*....|...
gi 67906814 261 KMSAYNLALMFAP 273
Cdd:cd04398 149 RMSVNNLAIIWGP 161
RhoGAP_GMIP cd04408
RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP ...
 130-278 1.83e-15

RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239873  Cd Length: 200  Bit Score: 74.85  E-value: 1.83e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 130 EYLHKNLRVEGLFRVPGNSVRQQILRDALNNGTD-IDLESGEFHsnDVATLLKMFLGELPEPLLTHKHFNAHLKIA-DLM 207
Cdd:cd04408  26 EIENRALGVQGIYRISGSKARVEKLCQAFENGRDlVDLSGHSPH--DITSVLKHFLKELPEPVLPFQLYDDFIALAkELQ 103

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 67906814 208 QFDDKGNKTNIPDKDrQIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKNKMSAYNLALMFAPHVLWP 278
Cdd:cd04408 104 RDSEKAAESPSIVEN-IIRSLKELLGRLPVSNYNTLRHLMAHLYRVAERFEDNKMSPNNLGIVFGPTLLRP 173
RhoGAP_ARAP cd04385
RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 136-279 2.19e-15

RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity is PIP3-dependent, ARAPs are considered integration points for phosphoinositide, Arf and Rho signaling. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239850  Cd Length: 184  Bit Score: 74.27  E-value: 2.19e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 136 LRVEGLFRVPG-NSVRQQIL----RDALNngtdIDLESGEFHSNDVATLLKMFLGELPEPLLTHKHFNAHLKIADlmqfd 210
Cdd:cd04385  31 LMSEGIYRKNGkNSSVKKLLeafrKDARS----VQLREGEYTVHDVADVLKRFLRDLPDPLLTSELHAEWIEAAE----- 101

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 67906814 211 dkgnktnIPDKDRQIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKNKMSAYNLALMFAPHVLWPK 279
Cdd:cd04385 102 -------LENKDERIARYKELIRRLPPINRATLKVLIGHLYRVQKHSDENQMSVHNLALVFGPTLFQTD 163
RhoGAP_ARHGAP22_24_25 cd04390
RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 134-308 2.45e-15

RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for Rac1 and Cdc42. Short isoforms (without the PH domain) of ARHGAP24, called RC-GAP72 and p73RhoGAP, and of ARHGAP22, called p68RacGAP, has been shown to be involved in angiogenesis and endothelial cell capillary formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239855 [Multi-domain]  Cd Length: 199  Bit Score: 74.40  E-value: 2.45e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 134 KNLRVEGLFRVPG--NSVRQqiLRDALNNGtdidlESGEFHSND----VATLLKMFLGELPEPLLTHKHFNAHLKIADLM 207
Cdd:cd04390  36 HGLKEEGLFRLPGqaNLVKQ--LQDAFDAG-----ERPSFDSDTdvhtVASLLKLYLRELPEPVIPWAQYEDFLSCAQLL 108

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 208 QFDDKGNKtnipdkdrqiEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKNKMSAYNLALMFAPHVLWPKNVTANDLQ 287
Cdd:cd04390 109 SKDEEKGL----------GELMKQVSILPKVNYNLLSYICRFLDEVQSNSSVNKMSVQNLATVFGPNILRPKVEDPATIM 178

                       170       180
                ....*....|....*....|.
gi 67906814 288 ENITKLNSGMAFMIKHSQKLF 308
Cdd:cd04390 179 EGTPQIQQLMTVMISKHEPLF 199
RhoGAP_p190 cd04373
RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 113-278 1.79e-14

RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an N-terminal GTPase domain and a C-terminal GAP domain. The central portion of p190 contains important regulatory phosphorylation sites. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239838  Cd Length: 185  Bit Score: 71.72  E-value: 1.79e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 113 FGSPLTEEGIAQ------IYQLIEYLHKN-LRVEGLFRVPGNSVRQQILRDALNNGTDIDLESGEFHSNDVATLLKMFLG 185
Cdd:cd04373   1 FGVPLANVVTSEkpipifLEKCVEFIEATgLETEGIYRVSGNKTHLDSLQKQFDQDHNLDLVSKDFTVNAVAGALKSFFS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 186 ELPEPLLThkhFNAHLKIADLMQfddkgnktnIPDKDRQIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKNKMSAY 265
Cdd:cd04373  81 ELPDPLIP---YSMHLELVEAAK---------INDREQRLHALKELLKKFPPENFDVFKYVITHLNKVSQNSKVNLMTSE 148

                       170
                ....*....|...
gi 67906814 266 NLALMFAPHVLWP 278
Cdd:cd04373 149 NLSICFWPTLMRP 161
RhoGAP_fLRG1 cd04397
RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 134-314 3.24e-14

RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal LRG1-like proteins. Yeast Lrg1p is required for efficient cell fusion, and mother-daughter cell separation, possibly through acting as a RhoGAP specifically regulating 1,3-beta-glucan synthesis. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239862  Cd Length: 213  Bit Score: 71.63  E-value: 3.24e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 134 KNLRVEGLFRVPGNSVRQQILRDALNNGTDidlESGEFHSNDV---ATLLKMFLGELPEPLLTHKHFNAHLKIADlmqfd 210
Cdd:cd04397  41 MDMSVEGVFRKNGNIRRLKELTEEIDKNPT---EVPDLSKENPvqlAALLKKFLRELPDPLLTFKLYRLWISSQK----- 112

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 211 dkgnktnIPDKDRQIEALQLLFLILPPPNRNLLKLLLDLLYQTAK-----KQDKNKMSAYNLALMFAPHVLWPKNvTAND 285
Cdd:cd04397 113 -------IEDEEERKRVLHLVYCLLPKYHRDTMEVLFSFLKWVSSfshidEETGSKMDIHNLATVITPNILYSKT-DNPN 184

                       170       180
                ....*....|....*....|....*....
gi 67906814 286 LQENITKLNSGMAFMIKHSQKLFKAPAYI 314
Cdd:cd04397 185 TGDEYFLAIEAVNYLIENNEEFCEVPDEL 213
RhoGAP_Bcr cd04387
RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr ...
 125-278 3.43e-14

RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr kinase domain, an N-terminal oligomerization domain, and a C-terminal PDZ binding domain, in addition to PH and C2 domains. Bcr is a negative regulator of: i) RacGTPase, via the Rho GAP domain, ii) the Ras-Raf-MEK-ERK pathway, via phosphorylation of the Ras binding protein AF-6, and iii) the Wnt signaling pathway through binding beta-catenin. Bcr can form a complex with beta-catenin and Tcf1. The Wnt signaling pathway is involved in cell proliferation, differentiation, and cell renewal. Bcr was discovered as a fusion partner of Abl. The Bcr-Abl fusion is characteristic for a large majority of chronic myelogenous leukemias (CML). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239852 [Multi-domain]  Cd Length: 196  Bit Score: 71.11  E-value: 3.43e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 125 IYQLIEYLHK-NLRVEGLFRVPGNSVRQQILRDALN-NGTDIDLESGEFHSNDVATLLKMFLGELPEPLLTHKHFnahLK 202
Cdd:cd04387  20 VRQCVEEVERrGMEEVGIYRISGVATDIQALKAAFDtNNKDVSVMLSEMDVNAIAGTLKLYFRELPEPLFTDELY---PN 96

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 67906814 203 IADLMQFDDKGNKTNipdkdrqieALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKNKMSAYNLALMFAPHVLWP 278
Cdd:cd04387  97 FAEGIALSDPVAKES---------CMLNLLLSLPDPNLVTFLFLLHHLKRVAEREEVNKMSLHNLATVFGPTLLRP 163
RhoGap_RalBP1 cd04381
RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 113-275 5.02e-12

RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 transiently associates with the centromere and has been shown to play an essential role in the proper assembly of the mitotic apparatus. RalBP1 is an effector of the Ral GTPase which itself is an effector of Ras. RalBP1 contains a RhoGAP domain, which shows weak activity towards Rac1 and Cdc42, but not towards Ral, and a Ral effector domain binding motif. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239846 [Multi-domain]  Cd Length: 182  Bit Score: 64.38  E-value: 5.02e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 113 FGSPLTE--------EGI---AQIYQLIEYLHK-NLRVEGLFRVPGNSVRQQILRDALNNGTDIDLEsgEFHSNDVATLL 180
Cdd:cd04381   1 FGASLSLaversrchDGIdlpLVFRECIDYVEKhGMKCEGIYKVSGIKSKVDELKAAYNRRESPNLE--EYEPPTVASLL 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 181 KMFLGELPEPLLThkhfnahlkiADLM-QFDDKGNKTNIPDKDRQieaLQLLFLILPPPNRNLLKLLLDLLYQTAKKQDK 259
Cdd:cd04381  79 KQYLRELPEPLLT----------KELMpRFEEACGRPTEAEREQE---LQRLLKELPECNRLLLAWLIVHMDHVIAQELE 145

                       170
                ....*....|....*.
gi 67906814 260 NKMSAYNLALMFAPHV 275
Cdd:cd04381 146 TKMNIQNISIVLSPTV 161
RhoGAP_Graf cd04374
RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase ...
 117-282 7.38e-11

RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal changes mediated by Rho proteins. Graf exhibits GAP activity toward RhoA and Cdc42, but only weakly activates Rac1. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239839  Cd Length: 203  Bit Score: 61.64  E-value: 7.38e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 117 LTEEGIAQIYQLIEYLH-KNLRVEGLFRVPGNSVRQQILRDALNN-----GTDIDLESGEFHSNDVATLLKMFLGELPEP 190
Cdd:cd04374  24 LDDIGFKFVRKCIEAVEtRGINEQGLYRVVGVNSKVQKLLSLGLDpktstPGDVDLDNSEWEIKTITSALKTYLRNLPEP 103

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 191 LLT---HKHFNAHLKIADLmqfddkgnktnipdkDRQIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKNKMSAYNL 267
Cdd:cd04374 104 LMTyelHNDFINAAKSENL---------------ESRVNAIHSLVHKLPEKNREMLELLIKHLTNVSDHSKKNLMTVSNL 168

                       170
                ....*....|....*
gi 67906814 268 ALMFAPHVLWPKNVT 282
Cdd:cd04374 169 GVVFGPTLLRPQEET 183
RhoGAP_chimaerin cd04372
RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 134-308 1.24e-10

RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms that each contain a C-terminal GAP domain, and a central C1 domain which binds phorbol esters, inducing a conformational change that activates the protein; one splice form is lacking the N-terminal Src homology-2 (SH2) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239837 [Multi-domain]  Cd Length: 194  Bit Score: 60.61  E-value: 1.24e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 134 KNLRVEGLFRVPGNSVRQQILRDALN-NGTDIDLESGEFHS-NDVATLLKMFLGELPEPLLThkhFNAHLKIADLMQfdd 211
Cdd:cd04372  30 RGLQSEGLYRVSGFAEEIEDVKMAFDrDGEKADISATVYPDiNVITGALKLYFRDLPIPVIT---YDTYPKFIDAAK--- 103

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 212 kgnktnIPDKDRQIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKNKMSAYNLALMFAPHVLWPKNVTANDLQENIT 291
Cdd:cd04372 104 ------ISNPDERLEAVHEALMLLPPAHYETLRYLMEHLKRVTLHEKDNKMNAENLGIVFGPTLMRPPEDSALTTLNDMR 177

                       170
                ....*....|....*..
gi 67906814 292 KLNSGMAFMIKHSQKLF 308
Cdd:cd04372 178 YQILIVQLLITNEDVLF 194
RhoGAP_CdGAP cd04384
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 112-279 6.65e-10

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239849 [Multi-domain]  Cd Length: 195  Bit Score: 58.67  E-value: 6.65e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 112 IFGSPLTE------EGIAQIYQ-LIEYLHKNLRVEGLFRVPGNSVRQQILRDALNNGTDIDLESGEF----HSndVATLL 180
Cdd:cd04384   2 VFGCDLTEhllnsgQDVPQVLKsCTEFIEKHGIVDGIYRLSGIASNIQRLRHEFDSEQIPDLTKDVYiqdiHS--VSSLC 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 181 KMFLGELPEPLLThkhFNAHLKIADLMQFDDKgnktnipdkDRQIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKN 260
Cdd:cd04384  80 KLYFRELPNPLLT---YQLYEKFSEAVSAASD---------EERLEKIHDVIQQLPPPHYRTLEFLMRHLSRLAKYCSIT 147

                       170
                ....*....|....*....
gi 67906814 261 KMSAYNLALMFAPHVLWPK 279
Cdd:cd04384 148 NMHAKNLAIVWAPNLLRSK 166
RhoGAP_MgcRacGAP cd04382
RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 136-273 2.10e-08

RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is critical for the structure of the central spindle by promoting microtuble bundling. ii) after phosphorylation by aurora B MgcRacGAP becomes an effective regulator of RhoA and plays an important role in the assembly of the contractile ring and the initiation of cytokinesis. MgcRacGAP-like proteins contain a N-terminal C1-like domain, and a C-terminal RhoGAP domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239847  Cd Length: 193  Bit Score: 54.22  E-value: 2.10e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 136 LRVEGLFRVPGnSVRQ-QILRDALNNG-TDIDLesGEFHSNDVATLLKMFLGELPEPLLTHKHFnahlkiADLMqfddkg 213
Cdd:cd04382  33 LTEEGLYRVSG-SEREvKALKEKFLRGkTVPNL--SKVDIHVICGCLKDFLRSLKEPLITFALW------KEFM------ 97

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 214 NKTNIPDKDRQIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDkNKMSAYNLALMFAP 273
Cdd:cd04382  98 EAAEILDEDNSRAALYQAISELPQPNRDTLAFLILHLQRVAQSPE-CKMDINNLARVFGP 156
RhoGAP_KIAA1688 cd04389
RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 137-303 4.31e-08

RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239854  Cd Length: 187  Bit Score: 53.16  E-value: 4.31e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 137 RVEGLFRVPGNSVRQQILRDALNNGtDIDLeSGEFHSNDVATLLKMFLGELPEPLLTHKHFNAHLKiadlmQFDDKGNKT 216
Cdd:cd04389  39 QTEGIFRVPGDIDEVNELKLRVDQW-DYPL-SGLEDPHVPASLLKLWLRELEEPLIPDALYQQCIS-----ASEDPDKAV 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 217 NIPDKDRQIEALQLLFLIlpppnrnllkllldLLYQTAKKQD---KNKMSAYNLALMFAPHVLWPKNVTANDLQENITKL 293
Cdd:cd04389 112 EIVQKLPIINRLVLCYLI--------------NFLQVFAQPEnvaHTKMDVSNLAMVFAPNILRCTSDDPRVIFENTRKE 177

                       170
                ....*....|
gi 67906814 294 NSGMAFMIKH 303
Cdd:cd04389 178 MSFLRTLIEH 187
RhoGAP_srGAP cd04383
RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 97-273 1.19e-07

RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an N-terminal FCH domain, a central RhoGAP domain and a C-terminal SH3 domain; this SH3 domain interacts with the intracellular proline-rich-tail of the Roundabout receptor (Robo). This interaction with Robo then activates the rhoGAP domain which in turn inhibits Cdc42 activity. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239848  Cd Length: 188  Bit Score: 52.04  E-value: 1.19e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814  97 FFRSLMSLKRKEKGVIfgsPLTEEgiaqiyQLIEYLHKN-LRVEGLFRVPGNSVRQQILRDALNNGTDIDLESGEFHS-N 174
Cdd:cd04383   3 FNGSLEEYIQDSGQAI---PLVVE------SCIRFINLYgLQHQGIFRVSGSQVEVNDIKNAFERGEDPLADDQNDHDiN 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 175 DVATLLKMFLGELPEPLLTHKHFNahlkiaDLMqfdDKGNKTNIPDKDRQIealQLLFLILPPPNRNLLKLLLDLLYQTA 254
Cdd:cd04383  74 SVAGVLKLYFRGLENPLFPKERFE------DLM---SCVKLENPTERVHQI---REILSTLPRSVIIVMRYLFAFLNHLS 141

                       170
                ....*....|....*....
gi 67906814 255 KKQDKNKMSAYNLALMFAP 273
Cdd:cd04383 142 QFSDENMMDPYNLAICFGP 160
RhoGAP_SYD1 cd04379
RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 134-278 1.65e-07

RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying axonal properties. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239844  Cd Length: 207  Bit Score: 51.70  E-value: 1.65e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 134 KNLRVEGLFRVPGNSVRQQILRDAL-NNGTDIDLESGEFHSNDVAT-LLKMFLGELPEPLLTHKHFNAHLKIADLMQFDD 211
Cdd:cd04379  32 RGLDVIGLYRLCGSAAKKKELRDAFeRNSAAVELSEELYPDINVITgVLKDYLRELPEPLITPQLYEMVLEALAVALPND 111

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 67906814 212 KgnKTNIPDKDRQIEALQLLflilpppNRNLLKLLLDLLYQTAKKQDKNKMSAYNLALMFAPHVLWP 278
Cdd:cd04379 112 V--QTNTHLTLSIIDCLPLS-------AKATLLLLLDHLSLVLSNSERNKMTPQNLAVCFGPVLMFC 169
RhoGAP_BRCC3-like cd04405
RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 178-315 1.48e-05

RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain and an N-terminal DEP (Disheveled, Egl-10, and Pleckstrin) domain. The function(s) of BRCC3 and DEPDC7 are unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239870  Cd Length: 235  Bit Score: 46.17  E-value: 1.48e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 178 TLLKMFlGELPEPLLTHKHFNAHLKIADLMQfddkGNKTNipdkdRQIEALQLLFLILPPPNRNLLKLLLDLLYQTAK-- 255
Cdd:cd04405 111 TIAKYY-GQLKEPLLTFHLFDIFVGILELLG----NGKEE-----VALEALQLCLLLLPPASRRELRRLLRFMARAAKnd 180

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 67906814 256 -----KQDKNKMsayNLALMFAPHVLWPKNVTANdlqeNITKLNSgmaFMIKHSQKLFKAPAYIR 315
Cdd:cd04405 181 mprlhKEIENRM---LVKQTFSRAILCSKDLDEG----LADLLVL---FLMDHHQDIFKVPGSLH 235
RhoGAP_OCRL1 cd04380
RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 125-279 3.55e-05

RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and a C-terminal Rho GAP domain, this GAP domain lacks the catalytic residue and therefore maybe inactive. OCRL-like proteins are type II inositol polyphosphate 5-phosphatases that can hydrolyze lipid PI(4,5)P2 and PI(3,4,5)P3 and soluble Ins(1,4,5)P3 and Ins(1,3,4,5)P4, but their individual specificities vary. The functionality of the RhoGAP domain is still unclear. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239845  Cd Length: 220  Bit Score: 45.02  E-value: 3.55e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 125 IYQLIEYLHKN-LRVEGLFRVPGNSV--RQQI--LRDALNNGTDiDLESGEFHSndVATLLKMFLGELPEPLLThKHFNA 199
Cdd:cd04380  54 IWRLVDYLYTRgLAQEGLFEEPGLPSepGELLaeIRDALDTGSP-FNSPGSAES--VAEALLLFLESLPDPIIP-YSLYE 129

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 200 HLKIADLMQFDDKgnktnipdkdrqieaLQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKNKMSAYNLALMFAPHVLWPK 279
Cdd:cd04380 130 RLLEAVANNEEDK---------------RQVIRISLPPVHRNVFVYLCSFLRELLSESADRGLDENTLATIFGRVLLRDP 194
RhoGAP_myosin_IXA cd04406
RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 125-276 3.62e-05

RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXA. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239871  Cd Length: 186  Bit Score: 44.61  E-value: 3.62e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67906814 125 IYQLIEYLHKN-LRVEGLFRVPGNSVRQQILRDALNngTDID-LESGEFHSNDVATLLKMFLGELPEPLLTHKHFNAHLK 202
Cdd:cd04406  19 VEKLINYIEMHgLYTEGIYRKSGSTNKIKELRQGLD--TDANsVNLDDYNIHVIASVFKQWLRDLPNPLMTFELYEEFLR 96

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 67906814 203 IADLmqfddkgnktnipdKDRQiEALQLLFLILPPPNRNLLKLLLDLLYQTAK---KQDKNKMSAYNLALMFAPHVL 276
Cdd:cd04406  97 AMGL--------------QERR-ETVRGVYSVIDQLSRTHLNTLERLIFHLVRialQEETNRMSANALAIVFAPCIL 158
RhoGAP_fRGD2 cd04399
RhoGAP_fRGD2: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 144-194 2.59e-03

RhoGAP_fRGD2: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD2-like proteins. Yeast Rgd2 is a GAP protein for Cdc42 and Rho5. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239864  Cd Length: 212  Bit Score: 39.24  E-value: 2.59e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 67906814 144 VPGNSVRQqiLRDALNNGTDIDLE---SGEFHSNDVATLLKMFLGELPEPLLTH 194
Cdd:cd04399  48 VSLKETHQ--LRNLLNKPKKPDKEviiLKKFEPSTVASVLKLYLLELPDSLIPH 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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