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Conserved domains on  [gi|16933565|ref|NP_149091|]
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cadherin-related family member 1 isoform 1 precursor [Homo sapiens]

Protein Classification

cadherin repeat domain-containing protein( domain architecture ID 10182011)

cadherin repeat domain-containing protein similar to cadherins, which are calcium-dependent cell adhesion proteins that preferentially interact with themselves in connecting cells

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  28268172
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 139-241 1.67e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.01  E-value: 1.67e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933565 139 PYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFL--QNLHSPFAVDRHSGVLRLQagATLDYERSRTHYITVVAKDGG 216
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsGNEDGLFSIDPSTGEITTA--KPLDREEQSSYTLTVTATDGG 78

                        90       100
                ....*....|....*....|....*
gi 16933565 217 GRlhgadvVFSATTTVTVNVEDVQD 241
Cdd:cd11304  79 GP------PLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 477-572 4.04e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.86  E-value: 4.04e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933565 477 YVARIPENAPGGSSVVAVTAVDPDTGPWGEVKYS-TYGTGADLFLIHPSTGLIYTQpwASLDAEATARYNFYVKAEDMEG 555
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSiVSGNEDGLFSIDPSTGEITTA--KPLDREEQSSYTLTVTATDGGG 79

                        90
                ....*....|....*....
gi 16933565 556 --KYSVAEVFITLLDVNDH 572
Cdd:cd11304  80 ppLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 250-349 2.03e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.46  E-value: 2.03e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933565 250 PYYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGN-DGAFEINETSGAISITQSpaqLQRE---VYELHVQVTEM 325
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNeDGLFSIDPSTGEITTAKP---LDREeqsSYTLTVTATDG 77

                        90       100
                ....*....|....*....|....
gi 16933565 326 spaGSPAAQATVPVTIRIVDLNNH 349
Cdd:cd11304  78 ---GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 588-679 1.18e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.12  E-value: 1.18e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933565 588 GTPV-KIEAIDEDaEEPNNLVDYSITHAEPANVFDINSHTGEIWLKnsiRSLDALHNitpgrdCLWSLEVQAKDRGSPSF 666
Cdd:cd11304  13 GTVVlTVSATDPD-SGENGEVTYSIVSGNEDGLFSIDPSTGEITTA---KPLDREEQ------SSYTLTVTATDGGGPPL 82

                        90
                ....*....|...
gi 16933565 667 STTALLKIDITDA 679
Cdd:cd11304  83 SSTATVTITVLDV 95
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 363-468 1.40e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 61.56  E-value: 1.40e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933565 363 FELSMNEHPPQGEILrgLKITVNDSDQGANAKFNLQLVG--PRGIFRVVPQTvlneAQVTIIVEnsaaIDFEKSKVLTFK 440
Cdd:cd11304   2 YEVSVPENAPPGTVV--LTVSATDPDSGENGEVTYSIVSgnEDGLFSIDPST----GEITTAKP----LDREEQSSYTLT 71

                        90       100
                ....*....|....*....|....*...
gi 16933565 441 LLAVEVNTPeKFSSTADVVIQLLDTNDN 468
Cdd:cd11304  72 VTATDGGGP-PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 42-130 3.44e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 60.40  E-value: 3.44e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933565  42 FSLPEDTPVGSHVYTLNGTDP---EGDPISYHISfDPSTRSVFSVDPTFGNITLVEELDREREDEIEAIISISDGLNLVA 118
Cdd:cd11304   4 VSVPENAPPGTVVLTVSATDPdsgENGEVTYSIV-SGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                        90
                ....*....|....*
gi 16933565 119 E---KVVILVTDAND 130
Cdd:cd11304  83 SstaTVTITVLDVND 97
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 139-241 1.67e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.01  E-value: 1.67e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933565 139 PYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFL--QNLHSPFAVDRHSGVLRLQagATLDYERSRTHYITVVAKDGG 216
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsGNEDGLFSIDPSTGEITTA--KPLDREEQSSYTLTVTATDGG 78

                        90       100
                ....*....|....*....|....*
gi 16933565 217 GRlhgadvVFSATTTVTVNVEDVQD 241
Cdd:cd11304  79 GP------PLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 477-572 4.04e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.86  E-value: 4.04e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933565 477 YVARIPENAPGGSSVVAVTAVDPDTGPWGEVKYS-TYGTGADLFLIHPSTGLIYTQpwASLDAEATARYNFYVKAEDMEG 555
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSiVSGNEDGLFSIDPSTGEITTA--KPLDREEQSSYTLTVTATDGGG 79

                        90
                ....*....|....*....
gi 16933565 556 --KYSVAEVFITLLDVNDH 572
Cdd:cd11304  80 ppLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 250-349 2.03e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.46  E-value: 2.03e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933565 250 PYYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGN-DGAFEINETSGAISITQSpaqLQRE---VYELHVQVTEM 325
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNeDGLFSIDPSTGEITTAKP---LDREeqsSYTLTVTATDG 77

                        90       100
                ....*....|....*....|....
gi 16933565 326 spaGSPAAQATVPVTIRIVDLNNH 349
Cdd:cd11304  78 ---GGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
477-567 4.19e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 80.04  E-value: 4.19e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933565   477 YVARIPENAPGGSSVVAVTAVDPDTGPWGEVKYS-TYGTGADLFLIHPSTGLIYTQpwASLDAEATARYNFYVKAEDM-- 553
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSiLGGGPGGNFRIDPDTGDISTT--KPLDRESIGEYELTVEATDSgg 78

                          90
                  ....*....|....
gi 16933565   554 EGKYSVAEVFITLL 567
Cdd:pfam00028  79 PPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 495-574 2.84e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.00  E-value: 2.84e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933565    495 TAVDPDTGPWGEVKYS-TYGTGADLFLIHPSTGLIYTQpwASLDAEATARYNFYVKAEDMEG--KYSVAEVFITLLDVND 571
Cdd:smart00112   1 SATDADSGENGKVTYSiLSGNDDGLFSIDPETGEITTT--KPLDREEQPEYTLTVEATDGGGppLSSTATVTITVLDVND 78


                   ...
gi 16933565    572 HPP 574
Cdd:smart00112  79 NAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 158-244 5.40e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 76.23  E-value: 5.40e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933565    158 HAVDRDTGSGGSVTYFL--QNLHSPFAVDRHSGVLRLQAgaTLDYERSRTHYITVVAKDGGGRLHgadvvfSATTTVTVN 235
Cdd:smart00112   1 SATDADSGENGKVTYSIlsGNDDGLFSIDPETGEITTTK--PLDREEQPEYTLTVEATDGGGPPL------SSTATVTIT 72


                   ....*....
gi 16933565    236 VEDVQDMAP 244
Cdd:smart00112  73 VLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
140-237 2.18e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.03  E-value: 2.18e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933565   140 YVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSP--FAVDRHSGVLRLQagATLDYERSRTHYITVVAKDGGG 217
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGgnFRIDPDTGDISTT--KPLDRESIGEYELTVEATDSGG 78

                          90       100
                  ....*....|....*....|
gi 16933565   218 RlhgadvVFSATTTVTVNVE 237
Cdd:pfam00028  79 P------PLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 588-679 1.18e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.12  E-value: 1.18e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933565 588 GTPV-KIEAIDEDaEEPNNLVDYSITHAEPANVFDINSHTGEIWLKnsiRSLDALHNitpgrdCLWSLEVQAKDRGSPSF 666
Cdd:cd11304  13 GTVVlTVSATDPD-SGENGEVTYSIVSGNEDGLFSIDPSTGEITTA---KPLDREEQ------SSYTLTVTATDGGGPPL 82

                        90
                ....*....|...
gi 16933565 667 STTALLKIDITDA 679
Cdd:cd11304  83 SSTATVTITVLDV 95
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 269-351 1.15e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 63.91  E-value: 1.15e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933565    269 VAMDGDRGKPNRILYSLVNGND-GAFEINETSGAISITqspAQLQRE---VYELHVQVTEMspaGSPAAQATVPVTIRIV 344
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDdGLFSIDPETGEITTT---KPLDREeqpEYTLTVEATDG---GGPPLSSTATVTITVL 74


                   ....*..
gi 16933565    345 DLNNHPP 351
Cdd:smart00112  75 DVNDNAP 81
Cadherin pfam00028
Cadherin domain;
251-343 1.33e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 61.55  E-value: 1.33e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933565   251 YYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGN-DGAFEINETSGAISITQspaQLQREV---YELHVQVTEms 326
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGpGGNFRIDPDTGDISTTK---PLDRESigeYELTVEATD-- 75

                          90
                  ....*....|....*..
gi 16933565   327 pAGSPAAQATVPVTIRI 343
Cdd:pfam00028  76 -SGGPPLSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 363-468 1.40e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 61.56  E-value: 1.40e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933565 363 FELSMNEHPPQGEILrgLKITVNDSDQGANAKFNLQLVG--PRGIFRVVPQTvlneAQVTIIVEnsaaIDFEKSKVLTFK 440
Cdd:cd11304   2 YEVSVPENAPPGTVV--LTVSATDPDSGENGEVTYSIVSgnEDGLFSIDPST----GEITTAKP----LDREEQSSYTLT 71

                        90       100
                ....*....|....*....|....*...
gi 16933565 441 LLAVEVNTPeKFSSTADVVIQLLDTNDN 468
Cdd:cd11304  72 VTATDGGGP-PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 42-130 3.44e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 60.40  E-value: 3.44e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933565  42 FSLPEDTPVGSHVYTLNGTDP---EGDPISYHISfDPSTRSVFSVDPTFGNITLVEELDREREDEIEAIISISDGLNLVA 118
Cdd:cd11304   4 VSVPENAPPGTVVLTVSATDPdsgENGEVTYSIV-SGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                        90
                ....*....|....*
gi 16933565 119 E---KVVILVTDAND 130
Cdd:cd11304  83 SstaTVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 595-678 8.01e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 55.82  E-value: 8.01e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933565    595 AIDEDaEEPNNLVDYSITHAEPANVFDINSHTGEIWLKnsiRSLDalhnitpgRDCL--WSLEVQAKDRGSPSFSTTALL 672
Cdd:smart00112   2 ATDAD-SGENGKVTYSILSGNDDGLFSIDPETGEITTT---KPLD--------REEQpeYTLTVEATDGGGPPLSSTATV 69


                   ....*.
gi 16933565    673 KIDITD 678
Cdd:smart00112  70 TITVLD 75
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 383-470 2.28e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 54.66  E-value: 2.28e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933565    383 TVNDSDQGANAKFNLQLVG--PRGIFRVVPQTvlneaqvtIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKfSSTADVVI 460
Cdd:smart00112   1 SATDADSGENGKVTYSILSgnDDGLFSIDPET--------GEITTTKPLDREEQPEYTLTVEATDGGGPPL-SSTATVTI 71

                           90
                   ....*....|
gi 16933565    461 QLLDTNDNVP 470
Cdd:smart00112  72 TVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
588-677 4.75e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 48.45  E-value: 4.75e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933565   588 GTPV-KIEAIDEDaEEPNNLVDYSITHAEPANVFDINSHTGEIWLKnsiRSLD----ALHNITpgrdclwsleVQAKDRG 662
Cdd:pfam00028  12 GTEVlTVTATDPD-LGPNGRIFYSILGGGPGGNFRIDPDTGDISTT---KPLDresiGEYELT----------VEATDSG 77

                          90
                  ....*....|....*
gi 16933565   663 SPSFSTTALLKIDIT 677
Cdd:pfam00028  78 GPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
42-95 2.21e-03

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 38.05  E-value: 2.21e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 16933565    42 FSLPEDTPVGSHVYTLNGTDPEGDP---ISYHISFDPSTRSvFSVDPTFGNITLVEE 95
Cdd:pfam00028   3 ASVPENAPVGTEVLTVTATDPDLGPngrIFYSILGGGPGGN-FRIDPDTGDISTTKP 58
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 61-133 4.27e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 36.94  E-value: 4.27e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 16933565     61 DPEGDPISYHISfDPSTRSVFSVDPTFGNITLVEELDREREDEIEAIISISDG--LNLVAE-KVVILVTDANDEAP 133
Cdd:smart00112   7 SGENGKVTYSIL-SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGggPPLSSTaTVTITVLDVNDNAP 81
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 139-241 1.67e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.01  E-value: 1.67e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933565 139 PYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFL--QNLHSPFAVDRHSGVLRLQagATLDYERSRTHYITVVAKDGG 216
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsGNEDGLFSIDPSTGEITTA--KPLDREEQSSYTLTVTATDGG 78

                        90       100
                ....*....|....*....|....*
gi 16933565 217 GRlhgadvVFSATTTVTVNVEDVQD 241
Cdd:cd11304  79 GP------PLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 477-572 4.04e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.86  E-value: 4.04e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933565 477 YVARIPENAPGGSSVVAVTAVDPDTGPWGEVKYS-TYGTGADLFLIHPSTGLIYTQpwASLDAEATARYNFYVKAEDMEG 555
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSiVSGNEDGLFSIDPSTGEITTA--KPLDREEQSSYTLTVTATDGGG 79

                        90
                ....*....|....*....
gi 16933565 556 --KYSVAEVFITLLDVNDH 572
Cdd:cd11304  80 ppLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 250-349 2.03e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.46  E-value: 2.03e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933565 250 PYYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGN-DGAFEINETSGAISITQSpaqLQRE---VYELHVQVTEM 325
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNeDGLFSIDPSTGEITTAKP---LDREeqsSYTLTVTATDG 77

                        90       100
                ....*....|....*....|....
gi 16933565 326 spaGSPAAQATVPVTIRIVDLNNH 349
Cdd:cd11304  78 ---GGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
477-567 4.19e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 80.04  E-value: 4.19e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933565   477 YVARIPENAPGGSSVVAVTAVDPDTGPWGEVKYS-TYGTGADLFLIHPSTGLIYTQpwASLDAEATARYNFYVKAEDM-- 553
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSiLGGGPGGNFRIDPDTGDISTT--KPLDRESIGEYELTVEATDSgg 78

                          90
                  ....*....|....
gi 16933565   554 EGKYSVAEVFITLL 567
Cdd:pfam00028  79 PPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 495-574 2.84e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.00  E-value: 2.84e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933565    495 TAVDPDTGPWGEVKYS-TYGTGADLFLIHPSTGLIYTQpwASLDAEATARYNFYVKAEDMEG--KYSVAEVFITLLDVND 571
Cdd:smart00112   1 SATDADSGENGKVTYSiLSGNDDGLFSIDPETGEITTT--KPLDREEQPEYTLTVEATDGGGppLSSTATVTITVLDVND 78


                   ...
gi 16933565    572 HPP 574
Cdd:smart00112  79 NAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 158-244 5.40e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 76.23  E-value: 5.40e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933565    158 HAVDRDTGSGGSVTYFL--QNLHSPFAVDRHSGVLRLQAgaTLDYERSRTHYITVVAKDGGGRLHgadvvfSATTTVTVN 235
Cdd:smart00112   1 SATDADSGENGKVTYSIlsGNDDGLFSIDPETGEITTTK--PLDREEQPEYTLTVEATDGGGPPL------SSTATVTIT 72


                   ....*....
gi 16933565    236 VEDVQDMAP 244
Cdd:smart00112  73 VLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
140-237 2.18e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.03  E-value: 2.18e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933565   140 YVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSP--FAVDRHSGVLRLQagATLDYERSRTHYITVVAKDGGG 217
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGgnFRIDPDTGDISTT--KPLDRESIGEYELTVEATDSGG 78

                          90       100
                  ....*....|....*....|
gi 16933565   218 RlhgadvVFSATTTVTVNVE 237
Cdd:pfam00028  79 P------PLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 588-679 1.18e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.12  E-value: 1.18e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933565 588 GTPV-KIEAIDEDaEEPNNLVDYSITHAEPANVFDINSHTGEIWLKnsiRSLDALHNitpgrdCLWSLEVQAKDRGSPSF 666
Cdd:cd11304  13 GTVVlTVSATDPD-SGENGEVTYSIVSGNEDGLFSIDPSTGEITTA---KPLDREEQ------SSYTLTVTATDGGGPPL 82

                        90
                ....*....|...
gi 16933565 667 STTALLKIDITDA 679
Cdd:cd11304  83 SSTATVTITVLDV 95
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 269-351 1.15e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 63.91  E-value: 1.15e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933565    269 VAMDGDRGKPNRILYSLVNGND-GAFEINETSGAISITqspAQLQRE---VYELHVQVTEMspaGSPAAQATVPVTIRIV 344
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDdGLFSIDPETGEITTT---KPLDREeqpEYTLTVEATDG---GGPPLSSTATVTITVL 74


                   ....*..
gi 16933565    345 DLNNHPP 351
Cdd:smart00112  75 DVNDNAP 81
Cadherin pfam00028
Cadherin domain;
251-343 1.33e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 61.55  E-value: 1.33e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933565   251 YYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGN-DGAFEINETSGAISITQspaQLQREV---YELHVQVTEms 326
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGpGGNFRIDPDTGDISTTK---PLDRESigeYELTVEATD-- 75

                          90
                  ....*....|....*..
gi 16933565   327 pAGSPAAQATVPVTIRI 343
Cdd:pfam00028  76 -SGGPPLSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 363-468 1.40e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 61.56  E-value: 1.40e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933565 363 FELSMNEHPPQGEILrgLKITVNDSDQGANAKFNLQLVG--PRGIFRVVPQTvlneAQVTIIVEnsaaIDFEKSKVLTFK 440
Cdd:cd11304   2 YEVSVPENAPPGTVV--LTVSATDPDSGENGEVTYSIVSgnEDGLFSIDPST----GEITTAKP----LDREEQSSYTLT 71

                        90       100
                ....*....|....*....|....*...
gi 16933565 441 LLAVEVNTPeKFSSTADVVIQLLDTNDN 468
Cdd:cd11304  72 VTATDGGGP-PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 42-130 3.44e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 60.40  E-value: 3.44e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933565  42 FSLPEDTPVGSHVYTLNGTDP---EGDPISYHISfDPSTRSVFSVDPTFGNITLVEELDREREDEIEAIISISDGLNLVA 118
Cdd:cd11304   4 VSVPENAPPGTVVLTVSATDPdsgENGEVTYSIV-SGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                        90
                ....*....|....*
gi 16933565 119 E---KVVILVTDAND 130
Cdd:cd11304  83 SstaTVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 595-678 8.01e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 55.82  E-value: 8.01e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933565    595 AIDEDaEEPNNLVDYSITHAEPANVFDINSHTGEIWLKnsiRSLDalhnitpgRDCL--WSLEVQAKDRGSPSFSTTALL 672
Cdd:smart00112   2 ATDAD-SGENGKVTYSILSGNDDGLFSIDPETGEITTT---KPLD--------REEQpeYTLTVEATDGGGPPLSSTATV 69


                   ....*.
gi 16933565    673 KIDITD 678
Cdd:smart00112  70 TITVLD 75
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 383-470 2.28e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 54.66  E-value: 2.28e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933565    383 TVNDSDQGANAKFNLQLVG--PRGIFRVVPQTvlneaqvtIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKfSSTADVVI 460
Cdd:smart00112   1 SATDADSGENGKVTYSILSgnDDGLFSIDPET--------GEITTTKPLDREEQPEYTLTVEATDGGGPPL-SSTATVTI 71

                           90
                   ....*....|
gi 16933565    461 QLLDTNDNVP 470
Cdd:smart00112  72 TVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
588-677 4.75e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 48.45  E-value: 4.75e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933565   588 GTPV-KIEAIDEDaEEPNNLVDYSITHAEPANVFDINSHTGEIWLKnsiRSLD----ALHNITpgrdclwsleVQAKDRG 662
Cdd:pfam00028  12 GTEVlTVTATDPD-LGPNGRIFYSILGGGPGGNFRIDPDTGDISTT---KPLDresiGEYELT----------VEATDSG 77

                          90
                  ....*....|....*
gi 16933565   663 SPSFSTTALLKIDIT 677
Cdd:pfam00028  78 GPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
42-95 2.21e-03

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 38.05  E-value: 2.21e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 16933565    42 FSLPEDTPVGSHVYTLNGTDPEGDP---ISYHISFDPSTRSvFSVDPTFGNITLVEE 95
Cdd:pfam00028   3 ASVPENAPVGTEVLTVTATDPDLGPngrIFYSILGGGPGGN-FRIDPDTGDISTTKP 58
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 61-133 4.27e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 36.94  E-value: 4.27e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 16933565     61 DPEGDPISYHISfDPSTRSVFSVDPTFGNITLVEELDREREDEIEAIISISDG--LNLVAE-KVVILVTDANDEAP 133
Cdd:smart00112   7 SGENGKVTYSIL-SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGggPPLSSTaTVTITVLDVNDNAP 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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