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Conserved domains on  [gi|15431306|ref|NP_150644|]
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large ribosomal subunit protein uL2 [Homo sapiens]

Protein Classification

large ribosomal subunit protein uL2( domain architecture ID 1904327)

large ribosomal subunit protein uL2 is a component of the large ribosomal subunit

Gene Ontology:  GO:0003735|GO:0003723|GO:0006412

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PTZ00180 super family cl42898
60S ribosomal protein L8; Provisional
1-254 1.51e-153

60S ribosomal protein L8; Provisional


The actual alignment was detected with superfamily member PTZ00180:

Pssm-ID: 173464 [Multi-domain]  Cd Length: 260  Bit Score: 427.61  E-value: 1.51e-153
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15431306    1 MGRVIRGQRKGAGSVFRAHVKHRKGAARLRAVDFAERHGYIKGIVKDIIHDPGRGAPLAKVVFRDPYRFKKRTELFIAAE 80
Cdd:PTZ00180   1 MGRVIRAQRKGNGSVFKAHGHKRLGPAKLRILDYAERHGYIRGVVKDIEHDPGRGAPLARVEFRDPYKYKRVKELMVAPE 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15431306   81 GIHTGQFVYCGKKAQLNIGNVLPVGTMPEGTIVCCLEEKPGDRGKLARASGNYATVISHNPETKKTRVKLPSGSKKVISS 160
Cdd:PTZ00180  81 GMYTGQYVYCGAKAPLAIGNVLPLGQIPEGTIVCNVEEKPGDRGTLARASGCYATIIGHSDDGGKTRIRLPSGQKKTVSS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15431306  161 ANRAVVGVVAGGGRIDKPILKAGRAYHKYKAKRNCWPRVRGVAMNPVEHPFGGGNHQHIGKPSTIRRDAPAGRKVGLIAA 240
Cdd:PTZ00180 161 LSRAMIGIVAGGGRIDKPVLKAGNAFHKYRGKRNCWPKVRGVAMNPVEHPHGGGNHQHIGHPSTVSRHAPPGQKVGLIAA 240
                        250
                 ....*....|....
gi 15431306  241 RRTGRLRGTKTVQE 254
Cdd:PTZ00180 241 RRTGLLRGGKKVKG 254
 
Name Accession Description Interval E-value
PTZ00180 PTZ00180
60S ribosomal protein L8; Provisional
1-254 1.51e-153

60S ribosomal protein L8; Provisional


Pssm-ID: 173464 [Multi-domain]  Cd Length: 260  Bit Score: 427.61  E-value: 1.51e-153
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15431306    1 MGRVIRGQRKGAGSVFRAHVKHRKGAARLRAVDFAERHGYIKGIVKDIIHDPGRGAPLAKVVFRDPYRFKKRTELFIAAE 80
Cdd:PTZ00180   1 MGRVIRAQRKGNGSVFKAHGHKRLGPAKLRILDYAERHGYIRGVVKDIEHDPGRGAPLARVEFRDPYKYKRVKELMVAPE 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15431306   81 GIHTGQFVYCGKKAQLNIGNVLPVGTMPEGTIVCCLEEKPGDRGKLARASGNYATVISHNPETKKTRVKLPSGSKKVISS 160
Cdd:PTZ00180  81 GMYTGQYVYCGAKAPLAIGNVLPLGQIPEGTIVCNVEEKPGDRGTLARASGCYATIIGHSDDGGKTRIRLPSGQKKTVSS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15431306  161 ANRAVVGVVAGGGRIDKPILKAGRAYHKYKAKRNCWPRVRGVAMNPVEHPFGGGNHQHIGKPSTIRRDAPAGRKVGLIAA 240
Cdd:PTZ00180 161 LSRAMIGIVAGGGRIDKPVLKAGNAFHKYRGKRNCWPKVRGVAMNPVEHPHGGGNHQHIGHPSTVSRHAPPGQKVGLIAA 240
                        250
                 ....*....|....
gi 15431306  241 RRTGRLRGTKTVQE 254
Cdd:PTZ00180 241 RRTGLLRGGKKVKG 254
Ribosomal_L2_C pfam03947
Ribosomal Proteins L2, C-terminal domain;
97-230 3.83e-51

Ribosomal Proteins L2, C-terminal domain;


Pssm-ID: 427606  Cd Length: 123  Bit Score: 162.93  E-value: 3.83e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15431306    97 NIGNVLPVGTMPEGTIVCCLEEKPGDRGKLARASGNYATVISHnpETKKTRVKLPSGSKKVISSANRAVVGVVAGGGRID 176
Cdd:pfam03947   1 KPGNALPLKNIPEGTIVHNIELKPGDGGQLARSAGTYAQIVAK--EGKYVTVRLPSGEVRLVSSDCRATIGVVSNGGHKN 78
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 15431306   177 KPILKAGRAYHKykakrNCWPRVRGVAMNPVEHPFGGGNhqhiGKpsTIRRDAP 230
Cdd:pfam03947  79 KPLGKAGRKRWL-----GRRPTVRGVAMNPVDHPHGGGE----GR--TVGRKHP 121
rplB_bact TIGR01171
ribosomal protein L2, bacterial/organellar; This model distinguishes bacterial and organellar ...
9-214 2.46e-29

ribosomal protein L2, bacterial/organellar; This model distinguishes bacterial and organellar ribosomal protein L2 from its counterparts in the archaea nad in the eukaryotic cytosol. Plant mitochondrial examples tend to have long, variable inserts. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273481 [Multi-domain]  Cd Length: 273  Bit Score: 111.25  E-value: 2.46e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15431306     9 RKGAGSVFRAHVKHRKGAA--RLRAVDFAERHGYIKGIVKDIIHDPGRGAPLAKVVFRDPyrfKKRteLFIAAEGIHTGQ 86
Cdd:TIGR01171  38 TGGRNNRGRITSRHRGGGHkrLYRIIDFKRDKDGIPAKVATIEYDPNRSARIALLHYADG---EKR--YILAPKGLKVGD 112
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15431306    87 FVYCGKKAQLNIGNVLPVGTMPEGTIVCCLEEKPGDRGKLARASGNYATVISHnpETKKTRVKLPSGSKKVISSANRAVV 166
Cdd:TIGR01171 113 TVISGPEAPIKPGNALPLRNIPVGTTVHNIELKPGKGGQLARSAGTSAQILAK--EGKYVTLRLPSGEMRMVLKECRATI 190
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 15431306   167 GVVAGGGRIDKPILKAGRAYHKykAKRncwPRVRGVAMNPVEHPFGGG 214
Cdd:TIGR01171 191 GEVGNEDHNNIVLGKAGRSRWL--GIR---PTVRGVAMNPVDHPHGGG 233
RplB COG0090
Ribosomal protein L2 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L2 ...
20-214 3.30e-27

Ribosomal protein L2 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L2 is part of the Pathway/BioSystem: Ribosome 50S subunit


Pssm-ID: 439860 [Multi-domain]  Cd Length: 276  Bit Score: 105.89  E-value: 3.30e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15431306  20 VKHRKGAA--RLRAVDFA-ERHGyIKGIVKDIIHDPGRGAPLAKVVFRDPyrfKKRteLFIAAEGIHTGQFVYCGKKAQL 96
Cdd:COG0090  51 VRHRGGGHkrKYRIIDFKrNKDG-IPAKVARIEYDPNRSARIALLHYADG---EKR--YILAPKGLKVGDTVVSGEDADI 124
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15431306  97 NIGNVLPVGTMPEGTIVCCLEEKPGDRGKLARASGNYATVISHnpETKKTRVKLPSGSKKVISS--------------AN 162
Cdd:COG0090 125 KPGNALPLKNIPVGTIVHNIELKPGKGGQLARSAGTSAQLMAK--EGKYATLRLPSGEVRKVLAecratigqvgnsdhEN 202
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 15431306 163 RAvvgvvagggridkpILKAGRAYHkyKAKRncwPRVRGVAMNPVEHPFGGG 214
Cdd:COG0090 203 IS--------------LGKAGRSRW--LGIR---PTVRGVAMNPVDHPHGGG 235
 
Name Accession Description Interval E-value
PTZ00180 PTZ00180
60S ribosomal protein L8; Provisional
1-254 1.51e-153

60S ribosomal protein L8; Provisional


Pssm-ID: 173464 [Multi-domain]  Cd Length: 260  Bit Score: 427.61  E-value: 1.51e-153
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15431306    1 MGRVIRGQRKGAGSVFRAHVKHRKGAARLRAVDFAERHGYIKGIVKDIIHDPGRGAPLAKVVFRDPYRFKKRTELFIAAE 80
Cdd:PTZ00180   1 MGRVIRAQRKGNGSVFKAHGHKRLGPAKLRILDYAERHGYIRGVVKDIEHDPGRGAPLARVEFRDPYKYKRVKELMVAPE 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15431306   81 GIHTGQFVYCGKKAQLNIGNVLPVGTMPEGTIVCCLEEKPGDRGKLARASGNYATVISHNPETKKTRVKLPSGSKKVISS 160
Cdd:PTZ00180  81 GMYTGQYVYCGAKAPLAIGNVLPLGQIPEGTIVCNVEEKPGDRGTLARASGCYATIIGHSDDGGKTRIRLPSGQKKTVSS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15431306  161 ANRAVVGVVAGGGRIDKPILKAGRAYHKYKAKRNCWPRVRGVAMNPVEHPFGGGNHQHIGKPSTIRRDAPAGRKVGLIAA 240
Cdd:PTZ00180 161 LSRAMIGIVAGGGRIDKPVLKAGNAFHKYRGKRNCWPKVRGVAMNPVEHPHGGGNHQHIGHPSTVSRHAPPGQKVGLIAA 240
                        250
                 ....*....|....
gi 15431306  241 RRTGRLRGTKTVQE 254
Cdd:PTZ00180 241 RRTGLLRGGKKVKG 254
rpl2p PRK09612
50S ribosomal protein L2P; Validated
1-247 5.81e-95

50S ribosomal protein L2P; Validated


Pssm-ID: 236589 [Multi-domain]  Cd Length: 238  Bit Score: 278.66  E-value: 5.81e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15431306    1 MGRVIRGQRKGAGS-VFRAHVKHRKGAARLRAVDFaerHGYIKGIVKDIIHDPGRGAPLAKVVFRDPYRFkkrteLFIAA 79
Cdd:PRK09612   1 MGKRIISQRRGRGTpTFRSPSHRYKGPVKYPPLDK---DGTLRGKVVDILHDPGRNAPVAKVKFENGEEF-----LILAP 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15431306   80 EGIHTGQFVYCGKKAQLNIGNVLPVGTMPEGTIVCCLEEKPGDRGKLARASGNYATVISHnpETKKTRVKLPSGSKKVIS 159
Cdd:PRK09612  73 EGLYVGQEIEIGPSAEIKPGNTLPLGEIPEGTPVCNIESRPGDGGKFARSSGTYALVVGH--EGDKVIVQLPSGKIKELN 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15431306  160 SANRAVVGVVAGGGRIDKPILKAGRAYHKYKAKRNCWPRVRGVAMNPVEHPFGGGNHQHIGKPSTIRRDAPAGRKVGLIA 239
Cdd:PRK09612 151 PRCRATIGVVAGGGRKEKPFLKAGKKYHKMKAKAKKWPRVRGVAMNAVDHPHGGGNHQHPGRPSTVSRNAPPGRKVGHIA 230

                 ....*...
gi 15431306  240 ARRTGRLR 247
Cdd:PRK09612 231 ARRTGRRK 238
Ribosomal_L2_C pfam03947
Ribosomal Proteins L2, C-terminal domain;
97-230 3.83e-51

Ribosomal Proteins L2, C-terminal domain;


Pssm-ID: 427606  Cd Length: 123  Bit Score: 162.93  E-value: 3.83e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15431306    97 NIGNVLPVGTMPEGTIVCCLEEKPGDRGKLARASGNYATVISHnpETKKTRVKLPSGSKKVISSANRAVVGVVAGGGRID 176
Cdd:pfam03947   1 KPGNALPLKNIPEGTIVHNIELKPGDGGQLARSAGTYAQIVAK--EGKYVTVRLPSGEVRLVSSDCRATIGVVSNGGHKN 78
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 15431306   177 KPILKAGRAYHKykakrNCWPRVRGVAMNPVEHPFGGGNhqhiGKpsTIRRDAP 230
Cdd:pfam03947  79 KPLGKAGRKRWL-----GRRPTVRGVAMNPVDHPHGGGE----GR--TVGRKHP 121
rplB_bact TIGR01171
ribosomal protein L2, bacterial/organellar; This model distinguishes bacterial and organellar ...
9-214 2.46e-29

ribosomal protein L2, bacterial/organellar; This model distinguishes bacterial and organellar ribosomal protein L2 from its counterparts in the archaea nad in the eukaryotic cytosol. Plant mitochondrial examples tend to have long, variable inserts. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273481 [Multi-domain]  Cd Length: 273  Bit Score: 111.25  E-value: 2.46e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15431306     9 RKGAGSVFRAHVKHRKGAA--RLRAVDFAERHGYIKGIVKDIIHDPGRGAPLAKVVFRDPyrfKKRteLFIAAEGIHTGQ 86
Cdd:TIGR01171  38 TGGRNNRGRITSRHRGGGHkrLYRIIDFKRDKDGIPAKVATIEYDPNRSARIALLHYADG---EKR--YILAPKGLKVGD 112
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15431306    87 FVYCGKKAQLNIGNVLPVGTMPEGTIVCCLEEKPGDRGKLARASGNYATVISHnpETKKTRVKLPSGSKKVISSANRAVV 166
Cdd:TIGR01171 113 TVISGPEAPIKPGNALPLRNIPVGTTVHNIELKPGKGGQLARSAGTSAQILAK--EGKYVTLRLPSGEMRMVLKECRATI 190
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 15431306   167 GVVAGGGRIDKPILKAGRAYHKykAKRncwPRVRGVAMNPVEHPFGGG 214
Cdd:TIGR01171 191 GEVGNEDHNNIVLGKAGRSRWL--GIR---PTVRGVAMNPVDHPHGGG 233
RplB COG0090
Ribosomal protein L2 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L2 ...
20-214 3.30e-27

Ribosomal protein L2 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L2 is part of the Pathway/BioSystem: Ribosome 50S subunit


Pssm-ID: 439860 [Multi-domain]  Cd Length: 276  Bit Score: 105.89  E-value: 3.30e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15431306  20 VKHRKGAA--RLRAVDFA-ERHGyIKGIVKDIIHDPGRGAPLAKVVFRDPyrfKKRteLFIAAEGIHTGQFVYCGKKAQL 96
Cdd:COG0090  51 VRHRGGGHkrKYRIIDFKrNKDG-IPAKVARIEYDPNRSARIALLHYADG---EKR--YILAPKGLKVGDTVVSGEDADI 124
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15431306  97 NIGNVLPVGTMPEGTIVCCLEEKPGDRGKLARASGNYATVISHnpETKKTRVKLPSGSKKVISS--------------AN 162
Cdd:COG0090 125 KPGNALPLKNIPVGTIVHNIELKPGKGGQLARSAGTSAQLMAK--EGKYATLRLPSGEVRKVLAecratigqvgnsdhEN 202
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 15431306 163 RAvvgvvagggridkpILKAGRAYHkyKAKRncwPRVRGVAMNPVEHPFGGG 214
Cdd:COG0090 203 IS--------------LGKAGRSRW--LGIR---PTVRGVAMNPVDHPHGGG 235
rpl2 CHL00052
ribosomal protein L2
20-234 5.53e-24

ribosomal protein L2


Pssm-ID: 176993  Cd Length: 273  Bit Score: 97.24  E-value: 5.53e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15431306   20 VKHRKGA-ARL-RAVDFAERHGYIKGIVKDIIHDPGRGAPLAKVVFRDPyrfKKRteLFIAAEGIHTGQFVYCGKKAQLN 97
Cdd:CHL00052  49 ARHRGGGhKRLyRKIDFRRNKKDIYGRIVTIEYDPNRNAYICLIHYGDG---EKR--YILHPRGLKIGDTIVSGTEAPIK 123
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15431306   98 IGNVLPVGTMPEGTIVCCLEEKPGDRGKLARASGNYATVISHnpETKKTRVKLPSGSKKVISSANRAVVGVVAGGGRIDK 177
Cdd:CHL00052 124 IGNALPLTNIPLGTAIHNIEITPGKGGQLARAAGAVAKLIAK--EGKSATLKLPSGEVRLISKNCSATIGQVGNVDVNNK 201
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15431306  178 PILKAGrayhkykakRNCW----PRVRGVAMNPVEHPFGGGNhqhiGKpstirrdAPAGRK 234
Cdd:CHL00052 202 SLGKAG---------SKRWlgkrPKVRGVVMNPVDHPHGGGE----GR-------APIGRK 242
PTZ00031 PTZ00031
ribosomal protein L2; Provisional
2-215 1.97e-23

ribosomal protein L2; Provisional


Pssm-ID: 173329 [Multi-domain]  Cd Length: 317  Bit Score: 96.45  E-value: 1.97e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15431306    2 GRVI------RGQRKGAGSVFRAHVKHRKG--AARLRAVDFAERHGYIKGIVKDIIHDPGRGAPLAKVVFRDPYrfkkrT 73
Cdd:PTZ00031  58 GRVVkqlscrRVKNSGRNNVGRITTRHRGGghVQRLRFIDFKRSRKDIYSTVLRIEYDPSRSAHIALLQYEDGV-----L 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15431306   74 ELFIAAEGIHTGQFVYCGKKAQLNIGNVLPVGTMPEGTIVCCLEEKPGDRGKLARASGNYATVISHNPETKKTRVKLPSG 153
Cdd:PTZ00031 133 SYILAPLLLRPGDKIIASKYANINPGNSLPLRNIPVGSIVHNVEMRPGAGGQIIRAGGTYATVVSKDEQFATLKLKSTEI 212
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15431306  154 SKKVISS-ANRAVVGVVAGGGRIDKpilKAGRAYhkYKAKRncwPRVRGVAMNPVEHPFGGGN 215
Cdd:PTZ00031 213 RKFPLDCwATIGQVSNLEHHMRILG---KAGVNR--WLGKR---PVVRGVAMNPSKHPHGGGT 267
Ribosomal_L2 pfam00181
Ribosomal Proteins L2, RNA binding domain;
11-90 4.44e-16

Ribosomal Proteins L2, RNA binding domain;


Pssm-ID: 395129 [Multi-domain]  Cd Length: 77  Bit Score: 70.72  E-value: 4.44e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15431306    11 GAGSVFRAHVKHRKGA--ARLRAVDFAERHGYIKGIVKDIIHDPGRGAPLAKVVFRDPYRFkkrteLFIAAEGIHTGQFV 88
Cdd:pfam00181   1 GRNNPGRITSRHRGGGhkKKYRLIDFKRNKDDVKGKVVEIEYDPNRNAPIALVKYEDGEKR-----YILAPEGLKVGDTV 75

                  ..
gi 15431306    89 YC 90
Cdd:pfam00181  76 ES 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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