protein dispatched homolog 2 [Homo sapiens]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| Sterol-sensing super family | cl48133 | Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ... |
574-639 | 6.37e-04 | ||
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus. The actual alignment was detected with superfamily member pfam12349: Pssm-ID: 463544 [Multi-domain] Cd Length: 153 Bit Score: 41.80 E-value: 6.37e-04
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| Name | Accession | Description | Interval | E-value | ||
| Sterol-sensing | pfam12349 | Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ... |
574-639 | 6.37e-04 | ||
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus. Pssm-ID: 463544 [Multi-domain] Cd Length: 153 Bit Score: 41.80 E-value: 6.37e-04
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| MMPL | COG1033 | Predicted exporter protein, RND superfamily [General function prediction only]; |
593-643 | 9.92e-04 | ||
Predicted exporter protein, RND superfamily [General function prediction only]; Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 43.70 E-value: 9.92e-04
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| 2A067 | TIGR00921 | The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
584-643 | 3.03e-03 | ||
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate] Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 42.13 E-value: 3.03e-03
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| Name | Accession | Description | Interval | E-value | ||
| Sterol-sensing | pfam12349 | Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ... |
574-639 | 6.37e-04 | ||
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus. Pssm-ID: 463544 [Multi-domain] Cd Length: 153 Bit Score: 41.80 E-value: 6.37e-04
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| MMPL | COG1033 | Predicted exporter protein, RND superfamily [General function prediction only]; |
593-643 | 9.92e-04 | ||
Predicted exporter protein, RND superfamily [General function prediction only]; Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 43.70 E-value: 9.92e-04
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| 2A067 | TIGR00921 | The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
584-643 | 3.03e-03 | ||
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate] Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 42.13 E-value: 3.03e-03
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| MMPL | COG1033 | Predicted exporter protein, RND superfamily [General function prediction only]; |
576-647 | 7.87e-03 | ||
Predicted exporter protein, RND superfamily [General function prediction only]; Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 40.61 E-value: 7.87e-03
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| Blast search parameters | ||||
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