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Conserved domains on  [gi|217035154|ref|NP_443094|]
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capZ-interacting protein isoform 1 [Homo sapiens]

Protein Classification

CAP-ZIP_m and RCSD domain-containing protein( domain architecture ID 11700656)

CAP-ZIP_m and RCSD domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
RCSD pfam05177
RCSD region; Proteins contain this region include C.elegans UNC-89. This region is found ...
229-329 3.27e-19

RCSD region; Proteins contain this region include C.elegans UNC-89. This region is found repeated in UNC-89 and shows conservation in prolines, lysines and glutamic acids. Proteins with RCSD are involved in muscle M-line assembly, but the function of this region RCSD is not clear.


:

Pssm-ID: 428350 [Multi-domain]  Cd Length: 101  Bit Score: 82.40  E-value: 3.27e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217035154  229 RTLGPAEKPPLRRSPSRTEKQEED-RATEEAKNGEKARRSSEEVDGQHPAQEEVPEsPQTSGPEAENRCGSPREEKPAGE 307
Cdd:pfam05177   1 RSPGKKEKPPLRRTSSRTEKQEEKgRAPEEAEHSPKAVGGSEEEKPKSPAKEEAVE-AQASSPEAANGCGSPTEEKKAGE 79
                          90       100
                  ....*....|....*....|..
gi 217035154  308 EAEMEKATEVKGERVQNEEVGP 329
Cdd:pfam05177  80 KVEEKKSSEVKEERAENEEDSP 101
CAP-ZIP_m super family cl21113
WASH complex subunit CAP-Z interacting, central region; This domain is found on WASH complex ...
81-166 6.50e-09

WASH complex subunit CAP-Z interacting, central region; This domain is found on WASH complex subunits FAM21 and CAP-ZIP proteins, as well as on VPEF (vaccinia virus penetration factor). This family of proteins is found in eukaryotes. Proteins in this family are typically between 305 and 1321 amino acids in length. The exact function of this region is not known.


The actual alignment was detected with superfamily member pfam15255:

Pssm-ID: 464595 [Multi-domain]  Cd Length: 140  Bit Score: 54.07  E-value: 6.50e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217035154   81 KSSPLIEKLQANLTFDPAALLPGASPKSPGLK-AMVSPFHSPPSTPSSPGVRSRPSE--AEEVPVSFDQPPEGSHLPCYN 157
Cdd:pfam15255   7 EPSSRIGKLQANLAINPAALLPGAAPQIPGAKsVLPGLAFPSSEPARSTSPESTPTAqgSGEAGVSFDLPAQADTLHSAN 86

                  ....*....
gi 217035154  158 KVRTRGSIK 166
Cdd:pfam15255  87 KSRAKVTGK 95
 
Name Accession Description Interval E-value
RCSD pfam05177
RCSD region; Proteins contain this region include C.elegans UNC-89. This region is found ...
229-329 3.27e-19

RCSD region; Proteins contain this region include C.elegans UNC-89. This region is found repeated in UNC-89 and shows conservation in prolines, lysines and glutamic acids. Proteins with RCSD are involved in muscle M-line assembly, but the function of this region RCSD is not clear.


Pssm-ID: 428350 [Multi-domain]  Cd Length: 101  Bit Score: 82.40  E-value: 3.27e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217035154  229 RTLGPAEKPPLRRSPSRTEKQEED-RATEEAKNGEKARRSSEEVDGQHPAQEEVPEsPQTSGPEAENRCGSPREEKPAGE 307
Cdd:pfam05177   1 RSPGKKEKPPLRRTSSRTEKQEEKgRAPEEAEHSPKAVGGSEEEKPKSPAKEEAVE-AQASSPEAANGCGSPTEEKKAGE 79
                          90       100
                  ....*....|....*....|..
gi 217035154  308 EAEMEKATEVKGERVQNEEVGP 329
Cdd:pfam05177  80 KVEEKKSSEVKEERAENEEDSP 101
CAP-ZIP_m pfam15255
WASH complex subunit CAP-Z interacting, central region; This domain is found on WASH complex ...
81-166 6.50e-09

WASH complex subunit CAP-Z interacting, central region; This domain is found on WASH complex subunits FAM21 and CAP-ZIP proteins, as well as on VPEF (vaccinia virus penetration factor). This family of proteins is found in eukaryotes. Proteins in this family are typically between 305 and 1321 amino acids in length. The exact function of this region is not known.


Pssm-ID: 464595 [Multi-domain]  Cd Length: 140  Bit Score: 54.07  E-value: 6.50e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217035154   81 KSSPLIEKLQANLTFDPAALLPGASPKSPGLK-AMVSPFHSPPSTPSSPGVRSRPSE--AEEVPVSFDQPPEGSHLPCYN 157
Cdd:pfam15255   7 EPSSRIGKLQANLAINPAALLPGAAPQIPGAKsVLPGLAFPSSEPARSTSPESTPTAqgSGEAGVSFDLPAQADTLHSAN 86

                  ....*....
gi 217035154  158 KVRTRGSIK 166
Cdd:pfam15255  87 KSRAKVTGK 95
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
223-413 2.70e-03

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 39.98  E-value: 2.70e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217035154   223 AAGEGVRTLGPAEKPPLRRSP----SRTEKQEEDRATEEAKNGEKARRSSEEVDGQHPAQEEVPESPQTSGPEAENRCGS 298
Cdd:TIGR00927  638 AEHTGERTGEEGERPTEAEGEngeeSGGEAEQEGETETKGENESEGEIPAERKGEQEGEGEIEAKEADHKGETEAEEVEH 717
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217035154   299 PREEKPAGEEAEMEKATEVKGERVQNE---EVGPEHDSQETKKLEEGAAVKETPHSPPGGVKGGDVPKQEKGKEKQQEGA 375
Cdd:TIGR00927  718 EGETEAEGTEDEGEIETGEEGEEVEDEgegEAEGKHEVETEGDRKETEHEGETEAEGKEDEDEGEIQAGEDGEMKGDEGA 797
                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 217035154   376 VLEPGCSPQTGP-AQLETSSEVQSEPAVPKPEDDTPVQD 413
Cdd:TIGR00927  798 EGKVEHEGETEAgEKDEHEGQSETQADDTEVKDETGEQE 836
PTZ00121 PTZ00121
MAEBL; Provisional
212-341 8.48e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 38.58  E-value: 8.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217035154  212 KAPGSPLSSEGAAGEGVRTLGPAEKPPLRRSPSRTEKQEEDRATEEAKNGEKARRSSEEVDGQHPAQEEVPESPQTSGPE 291
Cdd:PTZ00121 1517 KAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEE 1596
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 217035154  292 AENRcgSPREEKPAGEEAEMEKATEVKGERVQNEEVGPEHDSQETKKLEE 341
Cdd:PTZ00121 1597 VMKL--YEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAE 1644
 
Name Accession Description Interval E-value
RCSD pfam05177
RCSD region; Proteins contain this region include C.elegans UNC-89. This region is found ...
229-329 3.27e-19

RCSD region; Proteins contain this region include C.elegans UNC-89. This region is found repeated in UNC-89 and shows conservation in prolines, lysines and glutamic acids. Proteins with RCSD are involved in muscle M-line assembly, but the function of this region RCSD is not clear.


Pssm-ID: 428350 [Multi-domain]  Cd Length: 101  Bit Score: 82.40  E-value: 3.27e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217035154  229 RTLGPAEKPPLRRSPSRTEKQEED-RATEEAKNGEKARRSSEEVDGQHPAQEEVPEsPQTSGPEAENRCGSPREEKPAGE 307
Cdd:pfam05177   1 RSPGKKEKPPLRRTSSRTEKQEEKgRAPEEAEHSPKAVGGSEEEKPKSPAKEEAVE-AQASSPEAANGCGSPTEEKKAGE 79
                          90       100
                  ....*....|....*....|..
gi 217035154  308 EAEMEKATEVKGERVQNEEVGP 329
Cdd:pfam05177  80 KVEEKKSSEVKEERAENEEDSP 101
CAP-ZIP_m pfam15255
WASH complex subunit CAP-Z interacting, central region; This domain is found on WASH complex ...
81-166 6.50e-09

WASH complex subunit CAP-Z interacting, central region; This domain is found on WASH complex subunits FAM21 and CAP-ZIP proteins, as well as on VPEF (vaccinia virus penetration factor). This family of proteins is found in eukaryotes. Proteins in this family are typically between 305 and 1321 amino acids in length. The exact function of this region is not known.


Pssm-ID: 464595 [Multi-domain]  Cd Length: 140  Bit Score: 54.07  E-value: 6.50e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217035154   81 KSSPLIEKLQANLTFDPAALLPGASPKSPGLK-AMVSPFHSPPSTPSSPGVRSRPSE--AEEVPVSFDQPPEGSHLPCYN 157
Cdd:pfam15255   7 EPSSRIGKLQANLAINPAALLPGAAPQIPGAKsVLPGLAFPSSEPARSTSPESTPTAqgSGEAGVSFDLPAQADTLHSAN 86

                  ....*....
gi 217035154  158 KVRTRGSIK 166
Cdd:pfam15255  87 KSRAKVTGK 95
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
223-413 2.70e-03

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 39.98  E-value: 2.70e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217035154   223 AAGEGVRTLGPAEKPPLRRSP----SRTEKQEEDRATEEAKNGEKARRSSEEVDGQHPAQEEVPESPQTSGPEAENRCGS 298
Cdd:TIGR00927  638 AEHTGERTGEEGERPTEAEGEngeeSGGEAEQEGETETKGENESEGEIPAERKGEQEGEGEIEAKEADHKGETEAEEVEH 717
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217035154   299 PREEKPAGEEAEMEKATEVKGERVQNE---EVGPEHDSQETKKLEEGAAVKETPHSPPGGVKGGDVPKQEKGKEKQQEGA 375
Cdd:TIGR00927  718 EGETEAEGTEDEGEIETGEEGEEVEDEgegEAEGKHEVETEGDRKETEHEGETEAEGKEDEDEGEIQAGEDGEMKGDEGA 797
                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 217035154   376 VLEPGCSPQTGP-AQLETSSEVQSEPAVPKPEDDTPVQD 413
Cdd:TIGR00927  798 EGKVEHEGETEAgEKDEHEGQSETQADDTEVKDETGEQE 836
PTZ00121 PTZ00121
MAEBL; Provisional
212-341 8.48e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 38.58  E-value: 8.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217035154  212 KAPGSPLSSEGAAGEGVRTLGPAEKPPLRRSPSRTEKQEEDRATEEAKNGEKARRSSEEVDGQHPAQEEVPESPQTSGPE 291
Cdd:PTZ00121 1517 KAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEE 1596
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 217035154  292 AENRcgSPREEKPAGEEAEMEKATEVKGERVQNEEVGPEHDSQETKKLEE 341
Cdd:PTZ00121 1597 VMKL--YEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAE 1644
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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