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Conserved domains on  [gi|281371490|ref|NP_446418|]
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laminin subunit gamma-1 precursor [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LamNT smart00136
Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related ...
 42-282 5.54e-119

Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related protein such as Unc-6/ netrins.


:

Pssm-ID: 214532  Cd Length: 238  Bit Score: 373.62  E-value: 5.54e-119
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490     42 GGRPQRCMPEFVNAAFNVTVVATNTCGTP-PEEYCVQTGVTGVTKSCHLCDAGQLHLQHGAAFLTDYNNQADTTWWQSQT 120
Cdd:smart00136    1 AGRPRSCYPPFVNLAFGREVTATSTCGEPgPERYCKLVGHTEQGKKCDYCDARNPRRSHPAENLTDGNNPNNPTWWQSEP 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490    121 MLAGVQYpnsINLTLHLGKAFDITYVRLKFHTSRPeSFAIYKRTREDGPWIPYQYYSGSCENTYSKANRGFIRTGgDEQQ 200
Cdd:smart00136   81 LSNGPQN---VNLTLDLGKEFHVTYVILKFCSPRP-SLWILERSDFGKTWQPWQYFSSDCRRTFGRPPRGPITKG-NEDE 155

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490    201 ALCTDEFSDISPLTGGNVAFSTLEGRPSAYNFDNSPVLQEWVTATDIRVTLNRLNTFGDEVFND-PKVLKSYYYAISDFA 279
Cdd:smart00136  156 VICTSEYSDIVPLEGGEIAFSLLEGRPSATDFDNSPVLQEWVTATNIRVRLTRLRTLGDELMDDrPEVTRRYYYAISDIA 235


                    ...
gi 281371490    280 VGG 282
Cdd:smart00136  236 VGG 238
LamB smart00281
Laminin B domain;
552-676 4.86e-41

Laminin B domain;


:

Pssm-ID: 214597  Cd Length: 127  Bit Score: 147.41  E-value: 4.86e-41
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490    552 YFPRYFVAPAKFLGNQVLSYGQNLSFSFRVD--RRDTRLSAEDLVLEGAGLRVSVPliAQGNSYPSE-TTVKYIFRLHEA 628
Cdd:smart00281    2 NEPVYWVAPEQFLGDKVTSYGGKLRYTLSFDgrRGGTHVSAPDVILEGNGLRISHP--AEGPPLPDElTTVEVRFREENW 79

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*....
gi 281371490    629 TDYPWRPALSPfEFQKLLNNLTSIKIRGTYSERSAG-YLDDVTLQSARP 676
Cdd:smart00281   80 QYYGGRPVTRE-DLMMVLANLTAILIRATYSQQMAGsRLSDVSLEVAVP 127
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1034-1596 9.39e-18

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 90.12  E-value: 9.39e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1034 RLVKDKVAEHRVKLQELESLIANLGTGDETVTDQA--FEDRLKEAEREVTDLLREAQEV-------KDVDQNLMDRLQRV 1104
Cdd:TIGR02168  429 KLEEAELKELQAELEELEEELEELQEELERLEEALeeLREELEEAEQALDAAERELAQLqarldslERLQENLEGFSEGV 508

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1105 NNSLHSQiSRLHNIrntieeTGILAERARSRvESTEQLIEIASREL------EKAKMAAANVSITQPESTG--------- 1169
Cdd:TIGR02168  509 KALLKNQ-SGLSGI------LGVLSELISVD-EGYEAAIEAALGGRlqavvvENLNAAKKAIAFLKQNELGrvtflplds 580

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1170 ------EPNNMTLLAEE--ARRLAERHKQEADDI----------VRVAK---TANETSAE-AYNLLLRTLAGE------- 1220
Cdd:TIGR02168  581 ikgteiQGNDREILKNIegFLGVAKDLVKFDPKLrkalsyllggVLVVDdldNALELAKKlRPGYRIVTLDGDlvrpggv 660

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1221 --------NQTAL----EIEELNRKYEQAKNISQDLEKQAARV---HEEAKRAGDKAVEIYASVAQLTPVDSEALESEAN 1285
Cdd:TIGR02168  661 itggsaktNSSILerrrEIEELEEKIEELEEKIAELEKALAELrkeLEELEEELEQLRKELEELSRQISALRKDLARLEA 740

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1286 KIKKEAADLDRLiDQKLKDYEDLREDMRGKEHEVKNLLEKGKAEQQTADQLLARADAAKALAeeaakkgRNTLQEANDIL 1365
Cdd:TIGR02168  741 EVEQLEERIAQL-SKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKAL-------REALDELRAEL 812

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1366 NNLKdfdRRVNDNKTAAEEALRRIPAINRTIAEANEKTREAQLALGNAAA---DATEAKNKAHEaERIASGVQKNATSTK 1442
Cdd:TIGR02168  813 TLLN---EEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAeieELEELIEELES-ELEALLNERASLEEA 888

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1443 ADAERtfSEVTDLDNEVNGMLRQLEEAENELKRKQDDADQ--------DMMMAGMASQAAQEAELNARKAKNSVSSLLS- 1513
Cdd:TIGR02168  889 LALLR--SELEELSEELRELESKRSELRRELEELREKLAQlelrleglEVRIDNLQERLSEEYSLTLEEAEALENKIEDd 966

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1514 ------QLTDLLEQLGQLDTVDLNKLNEIEgSLNKAKDEMK--VSDLdrkvsnleNEARKQ-EAAILDYDRDIAEIIKDI 1584
Cdd:TIGR02168  967 eeearrRLKRLENKIKELGPVNLAAIEEYE-ELKERYDFLTaqKEDL--------TEAKETlEEAIEEIDREARERFKDT 1037

                          650
                   ....*....|..
gi 281371490  1585 hnLEDIKKTLPT 1596
Cdd:TIGR02168 1038 --FDQVNENFQR 1047
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
933-978 3.34e-14

Laminin-type epidermal growth factor-like domai;


:

Pssm-ID: 214543  Cd Length: 46  Bit Score: 68.11  E-value: 3.34e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 281371490    933 CDCHALGSTNGQCDIRTGQCECQPGITGQHCERCETNHFGFGPEGC 978
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 443-490 7.47e-14

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 66.99  E-value: 7.47e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 281371490   443 CSCDPSGS-TDECNVETGRCVCKDNVEGFSCERCKPGFFNLESSNPKGC 490
Cdd:pfam00053    1 CDCNPHGSlSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 396-443 4.17e-12

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 62.37  E-value: 4.17e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 281371490   396 CHCSPVGSLSTQCDSY-GRCSCKPGVMGDKCDRCQPGFHSLTEAGCRPC 443
Cdd:pfam00053    1 CDCNPHGSLSDTCDPEtGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 722-761 6.48e-12

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 61.60  E-value: 6.48e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 281371490   722 CTCNGH---SETCDPETGVCDCRDNTAGPHCEKCSDGYYGDST 761
Cdd:pfam00053    1 CDCNPHgslSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPS 43
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 882-930 2.07e-11

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 60.06  E-value: 2.07e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 281371490   882 CACNPYGTVQqqSSCNPVTGQCQCLPHVSGRDCGACDPGFYNLQ--SGQGC 930
Cdd:pfam00053    1 CDCNPHGSLS--DTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPsdPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 980-1027 3.51e-10

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 56.59  E-value: 3.51e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 281371490  980 PCDCHHEGSLSLQC-KDDGRCECREGFVGNRCDQCEENYFYNRSWP-GCQ 1027
Cdd:cd00055     1 PCDCNGHGSLSGQCdPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGgGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 826-873 8.67e-09

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 52.74  E-value: 8.67e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 281371490   826 CQCNDNIDPNavGNCNRLTGECLkCIYNTAGFYCDRCKEGFFGNPLAP 873
Cdd:pfam00053    1 CDCNPHGSLS--DTCDPETGQCL-CKPGVTGRHCDRCKPGYYGLPSDP 45
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 283-328 1.20e-06

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 46.96  E-value: 1.20e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 281371490  283 RCKCNGHASECVKNEFGKLVCNCKHNTYGVDCEKCLPFFNDRPWRR 328
Cdd:cd00055     1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQG 46
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 340-394 1.31e-04

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 41.18  E-value: 1.31e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 281371490   340 CDCNGR---SQECYFdpelyrstgHGGHCTnCRDNTDGAKCERCRENFFRLGNTEACS 394
Cdd:pfam00053    1 CDCNPHgslSDTCDP---------ETGQCL-CKPGVTGRHCDRCKPGYYGLPSDPPQG 48
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 770-818 1.53e-04

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 40.80  E-value: 1.53e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 281371490  770 PCPCPGGSSCAIVPKTKEVVCtHCPTGTAGKRCELCDDGYFGDPLGSNG 818
Cdd:cd00055     1 PCDCNGHGSLSGQCDPGTGQC-ECKPNTTGRRCDRCAPGYYGLPSQGGG 48
 
Name Accession Description Interval E-value
LamNT smart00136
Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related ...
 42-282 5.54e-119

Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related protein such as Unc-6/ netrins.


Pssm-ID: 214532  Cd Length: 238  Bit Score: 373.62  E-value: 5.54e-119
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490     42 GGRPQRCMPEFVNAAFNVTVVATNTCGTP-PEEYCVQTGVTGVTKSCHLCDAGQLHLQHGAAFLTDYNNQADTTWWQSQT 120
Cdd:smart00136    1 AGRPRSCYPPFVNLAFGREVTATSTCGEPgPERYCKLVGHTEQGKKCDYCDARNPRRSHPAENLTDGNNPNNPTWWQSEP 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490    121 MLAGVQYpnsINLTLHLGKAFDITYVRLKFHTSRPeSFAIYKRTREDGPWIPYQYYSGSCENTYSKANRGFIRTGgDEQQ 200
Cdd:smart00136   81 LSNGPQN---VNLTLDLGKEFHVTYVILKFCSPRP-SLWILERSDFGKTWQPWQYFSSDCRRTFGRPPRGPITKG-NEDE 155

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490    201 ALCTDEFSDISPLTGGNVAFSTLEGRPSAYNFDNSPVLQEWVTATDIRVTLNRLNTFGDEVFND-PKVLKSYYYAISDFA 279
Cdd:smart00136  156 VICTSEYSDIVPLEGGEIAFSLLEGRPSATDFDNSPVLQEWVTATNIRVRLTRLRTLGDELMDDrPEVTRRYYYAISDIA 235


                    ...
gi 281371490    280 VGG 282
Cdd:smart00136  236 VGG 238
Laminin_N pfam00055
Laminin N-terminal (Domain VI);
48-282 1.13e-113

Laminin N-terminal (Domain VI);


Pssm-ID: 459653  Cd Length: 230  Bit Score: 358.43  E-value: 1.13e-113
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490    48 CMPEFVNAAFNVTVVATNTCGT-PPEEYCVQTGVTGVtKSCHLCDAGQLHLQHGAAFLTDYNNQADTTWWQSQTMLagVQ 126
Cdd:pfam00055    1 CYPAFGNLAFGREVSATSTCGLnGPERYCILSGLEGG-KKCFICDSRDPHNSHPPSNLTDSNNGTNETWWQSETGV--IQ 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490   127 YPNsINLTLHLGKAFDITYVRLKFHTSRPESFAIYKRTREDGPWIPYQYYSGSCENTYSKANRGfiRTGGDEQQALCTDE 206
Cdd:pfam00055   78 YEN-VNLTLDLGKEFHFTYLILKFKSPRPAAMVLERSTDFGKTWQPYQYFASDCRRTFGRPSGP--SRGIKDDEVICTSE 154

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 281371490   207 FSDISPLTGGNVAFSTLEGRPSAYNFDNSPVLQEWVTATDIRVTLNRLNTFGDEVFNDPKVLKSYYYAISDFAVGG 282
Cdd:pfam00055  155 YSDISPLTGGEVIFSTLEGRPSANIFDYSPELQDWLTATNIRIRLLRLHTLGDELLDDPSVLRKYYYAISDISVGG 230
LamB smart00281
Laminin B domain;
552-676 4.86e-41

Laminin B domain;


Pssm-ID: 214597  Cd Length: 127  Bit Score: 147.41  E-value: 4.86e-41
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490    552 YFPRYFVAPAKFLGNQVLSYGQNLSFSFRVD--RRDTRLSAEDLVLEGAGLRVSVPliAQGNSYPSE-TTVKYIFRLHEA 628
Cdd:smart00281    2 NEPVYWVAPEQFLGDKVTSYGGKLRYTLSFDgrRGGTHVSAPDVILEGNGLRISHP--AEGPPLPDElTTVEVRFREENW 79

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*....
gi 281371490    629 TDYPWRPALSPfEFQKLLNNLTSIKIRGTYSERSAG-YLDDVTLQSARP 676
Cdd:smart00281   80 QYYGGRPVTRE-DLMMVLANLTAILIRATYSQQMAGsRLSDVSLEVAVP 127
Laminin_B pfam00052
Laminin B (Domain IV);
556-686 6.55e-41

Laminin B (Domain IV);


Pssm-ID: 459652  Cd Length: 136  Bit Score: 147.42  E-value: 6.55e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490   556 YFVAPAKFLGNQVLSYGQNLSFSFRVDRRD---TRLSAEDLVLEGAGLRVSVPLIAQGNSYPSETTvKYIFRLHEATdyp 632
Cdd:pfam00052    1 YWSAPEQFLGNKLTSYGGYLTYTVRYEPLPgggSLNSEPDVILEGNGLRLSYSSPDQPPPDPGQEQ-TYSVRLHEEN--- 76

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490   633 WR----PALSPFEFQKLLNNLTSIKIRGTYSERSAG-YLDDVTLQSARPGP-GVPATWVE 686
Cdd:pfam00052   77 WRdsdgAPVSREDFMMVLANLTAILIRATYSTGSGQvSLSNVSLDSAVPGGsGPPASWVE 136
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1034-1596 9.39e-18

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 90.12  E-value: 9.39e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1034 RLVKDKVAEHRVKLQELESLIANLGTGDETVTDQA--FEDRLKEAEREVTDLLREAQEV-------KDVDQNLMDRLQRV 1104
Cdd:TIGR02168  429 KLEEAELKELQAELEELEEELEELQEELERLEEALeeLREELEEAEQALDAAERELAQLqarldslERLQENLEGFSEGV 508

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1105 NNSLHSQiSRLHNIrntieeTGILAERARSRvESTEQLIEIASREL------EKAKMAAANVSITQPESTG--------- 1169
Cdd:TIGR02168  509 KALLKNQ-SGLSGI------LGVLSELISVD-EGYEAAIEAALGGRlqavvvENLNAAKKAIAFLKQNELGrvtflplds 580

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1170 ------EPNNMTLLAEE--ARRLAERHKQEADDI----------VRVAK---TANETSAE-AYNLLLRTLAGE------- 1220
Cdd:TIGR02168  581 ikgteiQGNDREILKNIegFLGVAKDLVKFDPKLrkalsyllggVLVVDdldNALELAKKlRPGYRIVTLDGDlvrpggv 660

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1221 --------NQTAL----EIEELNRKYEQAKNISQDLEKQAARV---HEEAKRAGDKAVEIYASVAQLTPVDSEALESEAN 1285
Cdd:TIGR02168  661 itggsaktNSSILerrrEIEELEEKIEELEEKIAELEKALAELrkeLEELEEELEQLRKELEELSRQISALRKDLARLEA 740

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1286 KIKKEAADLDRLiDQKLKDYEDLREDMRGKEHEVKNLLEKGKAEQQTADQLLARADAAKALAeeaakkgRNTLQEANDIL 1365
Cdd:TIGR02168  741 EVEQLEERIAQL-SKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKAL-------REALDELRAEL 812

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1366 NNLKdfdRRVNDNKTAAEEALRRIPAINRTIAEANEKTREAQLALGNAAA---DATEAKNKAHEaERIASGVQKNATSTK 1442
Cdd:TIGR02168  813 TLLN---EEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAeieELEELIEELES-ELEALLNERASLEEA 888

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1443 ADAERtfSEVTDLDNEVNGMLRQLEEAENELKRKQDDADQ--------DMMMAGMASQAAQEAELNARKAKNSVSSLLS- 1513
Cdd:TIGR02168  889 LALLR--SELEELSEELRELESKRSELRRELEELREKLAQlelrleglEVRIDNLQERLSEEYSLTLEEAEALENKIEDd 966

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1514 ------QLTDLLEQLGQLDTVDLNKLNEIEgSLNKAKDEMK--VSDLdrkvsnleNEARKQ-EAAILDYDRDIAEIIKDI 1584
Cdd:TIGR02168  967 eeearrRLKRLENKIKELGPVNLAAIEEYE-ELKERYDFLTaqKEDL--------TEAKETlEEAIEEIDREARERFKDT 1037

                          650
                   ....*....|..
gi 281371490  1585 hnLEDIKKTLPT 1596
Cdd:TIGR02168 1038 --FDQVNENFQR 1047
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1070-1594 1.68e-16

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 85.50  E-value: 1.68e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1070 EDRLKEAEREVTDLLREAQEVKDVDQNLMDRLQRVNnslhSQISRLHNIRNTIEETGILAERARSRVESTEQLI-EIASR 1148
Cdd:PRK03918  192 EELIKEKEKELEEVLREINEISSELPELREELEKLE----KEVKELEELKEEIEELEKELESLEGSKRKLEEKIrELEER 267

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1149 ------ELEKAKmaaanvsitqpESTGEPNNMTLLAEEARRLAERHKQEADDIVRVAKTANETSAEAYNLLLRTLAGENQ 1222
Cdd:PRK03918  268 ieelkkEIEELE-----------EKVKELKELKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEK 336

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1223 TAlEIEELNRKYEQAKNISQDLEKQaARVHEEAKRAGDKAVEIYASVAQLTPVDSEA-----------LESEANKIKKEA 1291
Cdd:PRK03918  337 EE-RLEELKKKLKELEKRLEELEER-HELYEEAKAKKEELERLKKRLTGLTPEKLEKeleelekakeeIEEEISKITARI 414

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1292 ADLDRLIDQKLKDYEDLREdMRGK---------EHEVKNLLEKGKAEQQTAdqllaradaakalaeeaakkgRNTLQEAN 1362
Cdd:PRK03918  415 GELKKEIKELKKAIEELKK-AKGKcpvcgreltEEHRKELLEEYTAELKRI---------------------EKELKEIE 472

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1363 DILNNLKDFDRRVnDNKTAAEEALRRIPAINRTIAEANEKTREaqlalgnaaADATEAKNKAHEAERI---ASGVQKNAT 1439
Cdd:PRK03918  473 EKERKLRKELREL-EKVLKKESELIKLKELAEQLKELEEKLKK---------YNLEELEKKAEEYEKLkekLIKLKGEIK 542

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1440 STKADAERTfsevtdldNEVNGMLRQLEEAENELKRKQDDADQDMMMAGMASqaaqEAELNAR------------KAKNS 1507
Cdd:PRK03918  543 SLKKELEKL--------EELKKKLAELEKKLDELEEELAELLKELEELGFES----VEELEERlkelepfyneylELKDA 610

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1508 VSSLLSQL-------TDLLEQLGQLDTVDlNKLNEIEGSLNKAK---DEMKVSDLDRKVSNLENEARKQEAAILDYDRDI 1577
Cdd:PRK03918  611 EKELEREEkelkkleEELDKAFEELAETE-KRLEELRKELEELEkkySEEEYEELREEYLELSRELAGLRAELEELEKRR 689

                         570
                  ....*....|....*..
gi 281371490 1578 AEIIKDIHNLEDIKKTL 1594
Cdd:PRK03918  690 EEIKKTLEKLKEELEER 706
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
933-978 3.34e-14

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 68.11  E-value: 3.34e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 281371490    933 CDCHALGSTNGQCDIRTGQCECQPGITGQHCERCETNHFGFGPEGC 978
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 1038-1592 4.48e-14

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 77.45  E-value: 4.48e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1038 DKVAEHRVKLQELESLIANLGTGDETVTdQAFEDRLKEAEREVTDLLREAQEVKDVDQNLMDRLQRVNNSLHSQISRL-- 1115
Cdd:pfam05483  169 EKTKKYEYEREETRQVYMDLNNNIEKMI-LAFEELRVQAENARLEMHFKLKEDHEKIQHLEEEYKKEINDKEKQVSLLli 247

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1116 --HNIRNTIEETGILAERARSRV-----------ESTEQLIEIA---SRELEKAKMAAANVSITQPESTGEPNNMT---- 1175
Cdd:pfam05483  248 qiTEKENKMKDLTFLLEESRDKAnqleektklqdENLKELIEKKdhlTKELEDIKMSLQRSMSTQKALEEDLQIATktic 327

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1176 -LLAEEARRLAERHKQEADDIVRVakTANETSAEAYNLLLRTlagenqtalEIEELNRKYEQAKNISQDLEKQAARVHEE 1254
Cdd:pfam05483  328 qLTEEKEAQMEELNKAKAAHSFVV--TEFEATTCSLEELLRT---------EQQRLEKNEDQLKIITMELQKKSSELEEM 396

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1255 AKRAGDKAVEIyasvaqltpvdsealeseaNKIKKEAADLDRLIDQKlKDYEDLREDMRGKEHEVKNLLEKGKAEqqtad 1334
Cdd:pfam05483  397 TKFKNNKEVEL-------------------EELKKILAEDEKLLDEK-KQFEKIAEELKGKEQELIFLLQAREKE----- 451

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1335 qllaradaakalaeeaakkgrntlqeandilnnLKDFDRRVNDNKTAAEEALRRIPAINRTIAeaNEKTREAQLAlGNAA 1414
Cdd:pfam05483  452 ---------------------------------IHDLEIQLTAIKTSEEHYLKEVEDLKTELE--KEKLKNIELT-AHCD 495

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1415 ADATEAKNKAHEAERIASGV---QKNATSTKADAERTFSEVTDLDNEVNGMLRQLEEAENELKRKQDDA----DQDMMMA 1487
Cdd:pfam05483  496 KLLLENKELTQEASDMTLELkkhQEDIINCKKQEERMLKQIENLEEKEMNLRDELESVREEFIQKGDEVkcklDKSEENA 575

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1488 GMASQAAQEAELNARKAKNSVSSLLSQLTD---LLEQLGQLDTVDLNKLNEIEGSLNKAkdEMKVSDLDRKvsnLENEAR 1564
Cdd:pfam05483  576 RSIEYEVLKKEKQMKILENKCNNLKKQIENknkNIEELHQENKALKKKGSAENKQLNAY--EIKVNKLELE---LASAKQ 650

                          570       580       590
                   ....*....|....*....|....*....|.
gi 281371490  1565 KQEAAILDYDRDIAeiIKDIHN---LEDIKK 1592
Cdd:pfam05483  651 KFEEIIDNYQKEIE--DKKISEeklLEEVEK 679
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 443-490 7.47e-14

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 66.99  E-value: 7.47e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 281371490   443 CSCDPSGS-TDECNVETGRCVCKDNVEGFSCERCKPGFFNLESSNPKGC 490
Cdd:pfam00053    1 CDCNPHGSlSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 932-979 2.64e-13

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 65.45  E-value: 2.64e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 281371490  932 SCDCHALGSTNGQCDIRTGQCECQPGITGQHCERCETNHFGF--GPEGCK 979
Cdd:cd00055     1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLpsQGGGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 933-981 5.98e-13

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 64.68  E-value: 5.98e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 281371490   933 CDCHALGSTNGQCDIRTGQCECQPGITGQHCERCETNHFGFGPEGCKPC 981
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 396-443 4.17e-12

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 62.37  E-value: 4.17e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 281371490   396 CHCSPVGSLSTQCDSY-GRCSCKPGVMGDKCDRCQPGFHSLTEAGCRPC 443
Cdd:pfam00053    1 CDCNPHGSLSDTCDPEtGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 722-761 6.48e-12

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 61.60  E-value: 6.48e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 281371490   722 CTCNGH---SETCDPETGVCDCRDNTAGPHCEKCSDGYYGDST 761
Cdd:pfam00053    1 CDCNPHgslSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPS 43
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1033-1592 8.82e-12

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 70.35  E-value: 8.82e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1033 YRLVKD--KVAEHRVKLQELESLIANLgtgdetvtdQAFEDRLKEAEREVTDLLREAQEVKDVDQNLMDRLQRVNNSLHS 1110
Cdd:COG1196   215 YRELKEelKELEAELLLLKLRELEAEL---------EELEAELEELEAELEELEAELAELEAELEELRLELEELELELEE 285

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1111 QISRLHNIRNTIEEtgilAERARSRVEstEQLIEIASRELEkakmaaanvsitqpestgepnnmtlLAEEARRLAERHKQ 1190
Cdd:COG1196   286 AQAEEYELLAELAR----LEQDIARLE--ERRRELEERLEE-------------------------LEEELAELEEELEE 334

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1191 EADDIVRVAKTANETSAEaynlllrtlagENQTALEIEELNRKYEQAKNISQDLEKQAARVHEEAKRAGDKAVEIYASVA 1270
Cdd:COG1196   335 LEEELEELEEELEEAEEE-----------LEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLE 403

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1271 QLTPVDS------EALESEANKIKKEAADLDRLIDQKLKDYEDLREDMRGKEHEVKNLLEKGKAEQQTADQLLARADAAK 1344
Cdd:COG1196   404 ELEEAEEallerlERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELL 483

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1345 ALAEEAAKKgRNTLQEANDILNNLKDFDRRVNDNK--------------------TAAEEAL-RRIPAINRTIAEANEKT 1403
Cdd:COG1196   484 EELAEAAAR-LLLLLEAEADYEGFLEGVKAALLLAglrglagavavligveaayeAALEAALaAALQNIVVEDDEVAAAA 562

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1404 RE--AQLALGNA------AADATEAKNKAHEAERIASGVQKNATSTKADAERTF-----SEVTDLDNEVNGMLRQLEEAE 1470
Cdd:COG1196   563 IEylKAAKAGRAtflpldKIRARAALAAALARGAIGAAVDLVASDLREADARYYvlgdtLLGRTLVAARLEAALRRAVTL 642

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1471 NELKRKQDDADQDMMMAGMASQAAQEAELNARKAKNSVSSLLSQLTDLLEQLGQLDTVDLNKLNEIEGSLNKAKDEMKVS 1550
Cdd:COG1196   643 AGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELE 722

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|..
gi 281371490 1551 DLDRKVSNLENEARKQEAAILDYDRDIAEIIKDIHNLEDIKK 1592
Cdd:COG1196   723 EEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEE 764
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 722-769 9.07e-12

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 61.22  E-value: 9.07e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 281371490  722 CTCNGH---SETCDPETGVCDCRDNTAGPHCEKCSDGYYGDSTLGTssDCQ 769
Cdd:cd00055     2 CDCNGHgslSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGG--GCQ 50
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 442-491 1.14e-11

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 60.83  E-value: 1.14e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 281371490  442 PCSCDPSGS-TDECNVETGRCVCKDNVEGFSCERCKPGFFNLeSSNPKGCT 491
Cdd:cd00055     1 PCDCNGHGSlSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGL-PSQGGGCQ 50
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 395-441 1.70e-11

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 60.45  E-value: 1.70e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 281371490  395 PCHCSPVGSLSTQCDSY-GRCSCKPGVMGDKCDRCQPGFHSLTEA--GCR 441
Cdd:cd00055     1 PCDCNGHGSLSGQCDPGtGQCECKPNTTGRRCDRCAPGYYGLPSQggGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 882-930 2.07e-11

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 60.06  E-value: 2.07e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 281371490   882 CACNPYGTVQqqSSCNPVTGQCQCLPHVSGRDCGACDPGFYNLQ--SGQGC 930
Cdd:pfam00053    1 CDCNPHGSLS--DTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPsdPPQGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
396-440 2.88e-11

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 59.63  E-value: 2.88e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 281371490    396 CHCSPVGSLSTQCDS-YGRCSCKPGVMGDKCDRCQPGFHSLTEAGC 440
Cdd:smart00180    1 CDCDPGGSASGTCDPdTGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
443-490 4.05e-11

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 59.25  E-value: 4.05e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 281371490    443 CSCDPSGS-TDECNVETGRCVCKDNVEGFSCERCKPGFFNlesSNPKGC 490
Cdd:smart00180    1 CDCDPGGSaSGTCDPDTGQCECKPNVTGRRCDRCAPGYYG---DGPPGC 46
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 881-931 7.21e-11

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 58.90  E-value: 7.21e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 281371490  881 ACACNPYGTVQQQssCNPVTGQCQCLPHVSGRDCGACDPGFYNLQS-GQGCE 931
Cdd:cd00055     1 PCDCNGHGSLSGQ--CDPGTGQCECKPNTTGRRCDRCAPGYYGLPSqGGGCQ 50
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
722-763 2.86e-10

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 56.94  E-value: 2.86e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 281371490    722 CTCNG---HSETCDPETGVCDCRDNTAGPHCEKCSDGYYGDSTLG 763
Cdd:smart00180    1 CDCDPggsASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPPG 45
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 980-1027 3.51e-10

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 56.59  E-value: 3.51e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 281371490  980 PCDCHHEGSLSLQC-KDDGRCECREGFVGNRCDQCEENYFYNRSWP-GCQ 1027
Cdd:cd00055     1 PCDCNGHGSLSGQCdPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGgGCQ 50
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
882-930 3.55e-10

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 56.55  E-value: 3.55e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 281371490    882 CACNPYGTVQqqSSCNPVTGQCQCLPHVSGRDCGACDPGFYNlQSGQGC 930
Cdd:smart00180    1 CDCDPGGSAS--GTCDPDTGQCECKPNVTGRRCDRCAPGYYG-DGPPGC 46
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
981-1026 9.92e-10

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 55.40  E-value: 9.92e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 281371490    981 CDCHHEGSLSLQC-KDDGRCECREGFVGNRCDQCEENYfYNRSWPGC 1026
Cdd:smart00180    1 CDCDPGGSASGTCdPDTGQCECKPNVTGRRCDRCAPGY-YGDGPPGC 46
growth_prot_Scy NF041483
polarized growth protein Scy;
1129-1504 3.32e-09

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 62.15  E-value: 3.32e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1129 AERARSRVES--------TEQLIEIASRELEKAKMAAANVSITqpeSTGEPNNMTLLAEEARRLAERHKQEADDIVRVAK 1200
Cdd:NF041483  202 AESARAEAEAilrrarkdAERLLNAASTQAQEATDHAEQLRSS---TAAESDQARRQAAELSRAAEQRMQEAEEALREAR 278

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1201 T-ANETSAEAYNLLLRTLAG-----ENQTALEIEELNRKYEQAKNISQDLEKQAARVHEEAK--------RAGDKAVEIY 1266
Cdd:NF041483  279 AeAEKVVAEAKEAAAKQLASaesanEQRTRTAKEEIARLVGEATKEAEALKAEAEQALADARaeaeklvaEAAEKARTVA 358

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1267 A--SVAQLTPVDSEALE-----------------SEANKIKKEA-ADLDRLIDQKlkdyEDLREDMRG------KEHEVK 1320
Cdd:NF041483  359 AedTAAQLAKAARTAEEvltkasedakattraaaEEAERIRREAeAEADRLRGEA----ADQAEQLKGaakddtKEYRAK 434

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1321 N--LLE-----KGKAEQQTADQLLARADAAKALAEEAAKKGRNTLQEANDILNNLK-DFDRRVNDNKTAAE----EALRR 1388
Cdd:NF041483  435 TveLQEearrlRGEAEQLRAEAVAEGERIRGEARREAVQQIEEAARTAEELLTKAKaDADELRSTATAESErvrtEAIER 514

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1389 IPAINRTIAEANEKTREaqlalgnaaadateaknkahEAERIASGVQKNATSTKADAERTFSEVTDlDNEVNGMLRQLEE 1468
Cdd:NF041483  515 ATTLRRQAEETLERTRA--------------------EAERLRAEAEEQAEEVRAAAERAARELRE-ETERAIAARQAEA 573

                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 281371490 1469 AEnELKRKQDDADQDMMMAGMA-SQAAQEAELNARKA 1504
Cdd:NF041483  574 AE-ELTRLHTEAEERLTAAEEAlADARAEAERIRREA 609
MA smart00283
Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo ...
 1089-1300 4.77e-09

Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.


Pssm-ID: 214599 [Multi-domain]  Cd Length: 262  Bit Score: 59.22  E-value: 4.77e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490   1089 EVKDVDQNLMDRLQRVNNSLHSQISRLHNIRNTIEETGILAERARSRVESTEQLIEIASRELEKAKMAAANVSITQPEST 1168
Cdd:smart00283    1 DVSEAVEEIAAGAEEQAEELEELAERMEELSASIEEVAANADEIAATAQSAAEAAEEGREAVEDAITAMDQIREVVEEAV 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490   1169 G-----------------------EPNNMTLL-------------------AEEARRLAERHKQEADDIVRVAKTANETS 1206
Cdd:smart00283   81 SaveeleessdeigeivsviddiaDQTNLLALnaaieaarageagrgfavvADEVRKLAERSAESAKEIESLIKEIQEET 160

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490   1207 AEAYNLLLRTLAGENQTALEIEELNRKYE----QAKNISQDLEKQAARVHEEAKRAGD--KAVEIYASVAQLTPVDSEAL 1280
Cdd:smart00283  161 NEAVAAMEESSSEVEEGVELVEETGDALEeivdSVEEIADLVQEIAAATDEQAAGSEEvnAAIDEIAQVTQETAAMSEEI 240

                           250       260
                    ....*....|....*....|
gi 281371490   1281 ESEANKIKKEAADLDRLIDQ 1300
Cdd:smart00283  241 SAAAEELSGLAEELDELVER 260
growth_prot_Scy NF041483
polarized growth protein Scy;
1065-1504 6.41e-09

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 61.00  E-value: 6.41e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1065 TDQAFEDRLKEAEREVTDLLREAQEvkdvdqnlmdRLQRVNNSL---HSQISRLHniRNTIEETGIL----AERARSRVE 1137
Cdd:NF041483  562 TERAIAARQAEAAEELTRLHTEAEE----------RLTAAEEALadaRAEAERIR--REAAEETERLrteaAERIRTLQA 629

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1138 STEQLIEIASRElekakmAAANVSITQPEstGEpNNMTLLAEEARRLAERHK---QEADDIVRV-AKTANE----TSAEA 1209
Cdd:NF041483  630 QAEQEAERLRTE------AAADASAARAE--GE-NVAVRLRSEAAAEAERLKseaQESADRVRAeAAAAAErvgtEAAEA 700

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1210 YNLLLRTLAGENQTALEI-----EELNRKYEQAKNISQDL-----------EKQAARVHEEA-KRAGD-------KAVEI 1265
Cdd:NF041483  701 LAAAQEEAARRRREAEETlgsarAEADQERERAREQSEELlasarkrveeaQAEAQRLVEEAdRRATElvsaaeqTAQQV 780

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1266 YASVAQLTPVDSE-------ALESEANKIKKEAAD-LDRL-------IDQKLKDYEDLREDMRGKEHEVKNLLEKGKAE- 1329
Cdd:NF041483  781 RDSVAGLQEQAEEeiaglrsAAEHAAERTRTEAQEeADRVrsdayaeRERASEDANRLRREAQEETEAAKALAERTVSEa 860

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1330 --------QQTADQLLARADAAKALAEEAAKKGRNTLQEANDILNNLKD-----FDRRVNDNKTAAEealrRIPAINRTI 1396
Cdd:NF041483  861 iaeaerlrSDASEYAQRVRTEASDTLASAEQDAARTRADAREDANRIRSdaaaqADRLIGEATSEAE----RLTAEARAE 936

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1397 AE--ANEKTREAQLALGNAAADATEAKNKAH-EAERIASGVQKNATSTKADAERTFSE----VTDLDNEVNGML------ 1463
Cdd:NF041483  937 AErlRDEARAEAERVRADAAAQAEQLIAEATgEAERLRAEAAETVGSAQQHAERIRTEaervKAEAAAEAERLRtearee 1016

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*...
gi 281371490 1464 --RQLEEAENEL-KRKQDDADQ-DMMMAGMASQAAQ---EAELNARKA 1504
Cdd:NF041483 1017 adRTLDEARKDAnKRRSEAAEQaDTLITEAAAEADQltaKAQEEALRT 1064
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 826-873 8.67e-09

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 52.74  E-value: 8.67e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 281371490   826 CQCNDNIDPNavGNCNRLTGECLkCIYNTAGFYCDRCKEGFFGNPLAP 873
Cdd:pfam00053    1 CDCNPHGSLS--DTCDPETGQCL-CKPGVTGRHCDRCKPGYYGLPSDP 45
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 981-1027 1.77e-08

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 51.97  E-value: 1.77e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 281371490   981 CDCHHEGSLSLQC-KDDGRCECREGFVGNRCDQCEENYFYNRSWPGCQ 1027
Cdd:pfam00053    1 CDCNPHGSLSDTCdPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQG 48
growth_prot_Scy NF041483
polarized growth protein Scy;
1070-1503 3.22e-08

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 58.68  E-value: 3.22e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1070 EDRLKEAEREVTDLLREAQE--VKDVDQNLMDRLQRVNNSlHSQISRLHNiRNTIEETGILAE----RARSRVEStEQLI 1143
Cdd:NF041483  271 EEALREARAEAEKVVAEAKEaaAKQLASAESANEQRTRTA-KEEIARLVG-EATKEAEALKAEaeqaLADARAEA-EKLV 347

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1144 EIASrelEKAKMAAANVSITQ---PESTGEpNNMTLLAEEARRLAERHKQEADDIVRVAKT-ANETSAEAYNLL--LRTL 1217
Cdd:NF041483  348 AEAA---EKARTVAAEDTAAQlakAARTAE-EVLTKASEDAKATTRAAAEEAERIRREAEAeADRLRGEAADQAeqLKGA 423

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1218 AGEN------QTALEIEELNRKYEQAKNISQDLEKQAARVHEEAKRAGDKAVEIYASVAQ--LTPVDSEALE------SE 1283
Cdd:NF041483  424 AKDDtkeyraKTVELQEEARRLRGEAEQLRAEAVAEGERIRGEARREAVQQIEEAARTAEelLTKAKADADElrstatAE 503

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1284 ANKIKKEAadLDRLIDQKlKDYEDLREDMRGKEHEVKNllekgKAEQQTADQLLARADAAKALAEEAAKKGRNTLQEAND 1363
Cdd:NF041483  504 SERVRTEA--IERATTLR-RQAEETLERTRAEAERLRA-----EAEEQAEEVRAAAERAARELREETERAIAARQAEAAE 575

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1364 ILNNLK-DFDRRVndnkTAAEEAL----------RRIPA--INRTIAEANEKTR--------EAQLALGNAAADATEAKN 1422
Cdd:NF041483  576 ELTRLHtEAEERL----TAAEEALadaraeaeriRREAAeeTERLRTEAAERIRtlqaqaeqEAERLRTEAAADASAARA 651

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1423 K------------AHEAERIASGVQKNATSTKAD----AERTFSEVTD-LDNEVNGMLRQLEEAENELKRKQDDADQDMm 1485
Cdd:NF041483  652 EgenvavrlrseaAAEAERLKSEAQESADRVRAEaaaaAERVGTEAAEaLAAAQEEAARRRREAEETLGSARAEADQER- 730

                         490
                  ....*....|....*...
gi 281371490 1486 maGMASQAAQEAELNARK 1503
Cdd:NF041483  731 --ERAREQSEELLASARK 746
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 825-874 5.71e-08

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 50.43  E-value: 5.71e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 281371490  825 PCQCNDNIDPNavGNCNRLTGECLkCIYNTAGFYCDRCKEGFFGNPLAPN 874
Cdd:cd00055     1 PCDCNGHGSLS--GQCDPGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQGG 47
growth_prot_Scy NF041483
polarized growth protein Scy;
1067-1572 7.05e-08

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 57.53  E-value: 7.05e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1067 QAFEDRL-KEAEREVTDLL----REAQEVKDVDQNLMDRLQRvnnslhsQISRLhniRNTIEETgilAERARSrvESTEQ 1141
Cdd:NF041483  752 QAEAQRLvEEADRRATELVsaaeQTAQQVRDSVAGLQEQAEE-------EIAGL---RSAAEHA---AERTRT--EAQEE 816

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1142 LIEIASRELEKAKMAAANVSITQPESTGEpnnmtllAEEARRLAERHKQEA-DDIVRVAKTANETSAEAYNLLLRTLAGE 1220
Cdd:NF041483  817 ADRVRSDAYAERERASEDANRLRREAQEE-------TEAAKALAERTVSEAiAEAERLRSDASEYAQRVRTEASDTLASA 889

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1221 NQTALEIEELNRkyEQAKNISQDLEKQAARVHEEAKRAGDKAVEiyASVAQLTPVDSEALESEANKIKKEAADLDRLIDQ 1300
Cdd:NF041483  890 EQDAARTRADAR--EDANRIRSDAAAQADRLIGEATSEAERLTA--EARAEAERLRDEARAEAERVRADAAAQAEQLIAE 965

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1301 KLKDYEDLR--------------EDMRGKEHEVKNLLEkGKAEQQTADqllaradaakalaeeAAKKGRNTLQEANdiln 1366
Cdd:NF041483  966 ATGEAERLRaeaaetvgsaqqhaERIRTEAERVKAEAA-AEAERLRTE---------------AREEADRTLDEAR---- 1025

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1367 nlKDFDRRVNDnktAAEEALRripAINRTIAEANEKTREAQLALGNAAADATEAKNKA-----HEAERIAS--------- 1432
Cdd:NF041483 1026 --KDANKRRSE---AAEQADT---LITEAAAEADQLTAKAQEEALRTTTEAEAQADTMvgaarKEAERIVAeatvegnsl 1097

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1433 -------------GVQKNATSTKADAE----RTFSEVTDLDNevngmlRQLEEAENELKRKQDDADQdMMMAGMASQAAQ 1495
Cdd:NF041483 1098 vekartdadellvGARRDATAIRERAEelrdRITGEIEELHE------RARRESAEQMKSAGERCDA-LVKAAEEQLAEA 1170

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 281371490 1496 EAelnarKAKNSVSSLLSQLTdlleqlgqldTVDLNKLNEIEGSLNKAkdEMKVSDLDRKVSNLENEARKQEAAILD 1572
Cdd:NF041483 1171 EA-----KAKELVSDANSEAS----------KVRIAAVKKAEGLLKEA--EQKKAELVREAEKIKAEAEAEAKRTVE 1230
growth_prot_Scy NF041483
polarized growth protein Scy;
1049-1514 6.33e-07

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 54.45  E-value: 6.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1049 ELESLIANLGTGDETVTDQAFEDRLKEAEREVTDLLREAQE-VKDVDQNLMDRLQRVNNSLHSQISRLHNIRNTIEE--- 1124
Cdd:NF041483  342 EAEKLVAEAAEKARTVAAEDTAAQLAKAARTAEEVLTKASEdAKATTRAAAEEAERIRREAEAEADRLRGEAADQAEqlk 421

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1125 -------------TGILAERARSRVESTEQLIEIASRELEKAKMAAANVSITQPESTgepnnmtllAEEARRLAERHKQE 1191
Cdd:NF041483  422 gaakddtkeyrakTVELQEEARRLRGEAEQLRAEAVAEGERIRGEARREAVQQIEEA---------ARTAEELLTKAKAD 492

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1192 ADDIVRVAKTANETsaeaynllLRTLAGENQTAL--EIEE-LNRKYEQAKNISQDLEKQAARVHEEAKRAG-------DK 1261
Cdd:NF041483  493 ADELRSTATAESER--------VRTEAIERATTLrrQAEEtLERTRAEAERLRAEAEEQAEEVRAAAERAArelreetER 564

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1262 AVEIYASVA--QLTPVDSEALE-------------SEANKIKKEAAD-LDRLidqKLKDYEDLREDMRGKEHEVKNLLEK 1325
Cdd:NF041483  565 AIAARQAEAaeELTRLHTEAEErltaaeealadarAEAERIRREAAEeTERL---RTEAAERIRTLQAQAEQEAERLRTE 641

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1326 GKAEQQTADqllaradaakalaeeaakkgrntlQEANDILNNLKDfdrrvndnkTAAEEALRRipainRTIA-EANEKTR 1404
Cdd:NF041483  642 AAADASAAR------------------------AEGENVAVRLRS---------EAAAEAERL-----KSEAqESADRVR 683

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1405 -EAQLALGNAAADATEAKNKAH-EAERIASGVQKNATSTKADAERTFSEVTDLDNEVNGMLR-QLEEAENELKRKQDDAD 1481
Cdd:NF041483  684 aEAAAAAERVGTEAAEALAAAQeEAARRRREAEETLGSARAEADQERERAREQSEELLASARkRVEEAQAEAQRLVEEAD 763

                         490       500       510
                  ....*....|....*....|....*....|...
gi 281371490 1482 QdmmmagMASQAAQEAELNARKAKNSVSSLLSQ 1514
Cdd:NF041483  764 R------RATELVSAAEQTAQQVRDSVAGLQEQ 790
ClyA_Cry6Aa-like cd22656
Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes ...
 1192-1333 8.71e-07

Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes pesticidal Cry6Aa toxin from Bacillus thuringiensis, one of the many parasporal crystal (Cry) toxins produced during the sporulation phase of growth. Many of these proteins are toxic to numerous insect species and have been effectively used as proteinaceous insecticides to directly kill insect pests; some have been used to control insect growth on transgenic agricultural plants. Cry6Aa exists as a protoxin, which is activated by cleavage using trypsin. Structure studies for Cry6Aa support a mechanism of action by pore formation, similar to cytolysin A (ClyA)-type alpha pore-forming toxins (alpha-PFTs) such as HblB, and bioassay and mutation studies show that Cry6Aa is an active pore-forming toxin. Cry6Aa shows atypical features compared to other members of alpha-PFTs, including internal repeat sequences and small loop regions within major alpha helices.


Pssm-ID: 439154 [Multi-domain]  Cd Length: 309  Bit Score: 52.76  E-value: 8.71e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1192 ADDIVRVAKTANETSAEAYNLLLRtLAGENQTALEIEELNRKYEQAKNISQDLEKQAARVHEEAKRAGDKaveiYASVAQ 1271
Cdd:cd22656    75 AGDIYNYAQNAGGTIDSYYAEILE-LIDDLADATDDEELEEAKKTIKALLDDLLKEAKKYQDKAAKVVDK----LTDFEN 149

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 281371490 1272 LTPVDSEALESEANKIKK---------EAADLDRLIDQKLKDYEDLREDMRGKEHEVKNLLEKGKAEQQTA 1333
Cdd:cd22656   150 QTEKDQTALETLEKALKDlltdeggaiARKEIKDLQKELEKLNEEYAAKLKAKIDELKALIADDEAKLAAA 220
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 283-328 1.20e-06

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 46.96  E-value: 1.20e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 281371490  283 RCKCNGHASECVKNEFGKLVCNCKHNTYGVDCEKCLPFFNDRPWRR 328
Cdd:cd00055     1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQG 46
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
826-870 7.02e-05

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 41.53  E-value: 7.02e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 281371490    826 CQCNDniDPNAVGNCNRLTGECLkCIYNTAGFYCDRCKEGFFGNP 870
Cdd:smart00180    1 CDCDP--GGSASGTCDPDTGQCE-CKPNVTGRRCDRCAPGYYGDG 42
growth_prot_Scy NF041483
polarized growth protein Scy;
1071-1565 7.84e-05

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 47.51  E-value: 7.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1071 DRLK-EAEREvtdlLREAQ-EVKDVDQNLMDRLQRVNNSLHSQ-ISR-------LHNIRNTIE----ETGILAERARSRV 1136
Cdd:NF041483   86 DQLRaDAERE----LRDARaQTQRILQEHAEHQARLQAELHTEaVQRrqqldqeLAERRQTVEshvnENVAWAEQLRART 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1137 ES-TEQLIEIASRELEKAkMAAANVsitqpestgepnnmtllaeEARRLAERHKQeaddivRVAKTANETSAEAYNLLLR 1215
Cdd:NF041483  162 ESqARRLLDESRAEAEQA-LAAARA-------------------EAERLAEEARQ------RLGSEAESARAEAEAILRR 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1216 TLAGENQTaleieeLNRKYEQAknisqdlekQAARVHEEAKRAgdkaveiyasvaqltpvdSEALESEAnkIKKEAADLD 1295
Cdd:NF041483  216 ARKDAERL------LNAASTQA---------QEATDHAEQLRS------------------STAAESDQ--ARRQAAELS 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1296 RLIDQKLKDYEdlrEDMRGKEHEVKNLLEKGK--AEQQTAdqllaradaakalaeeaakkgrnTLQEANDilnnlkdfdr 1373
Cdd:NF041483  261 RAAEQRMQEAE---EALREARAEAEKVVAEAKeaAAKQLA-----------------------SAESANE---------- 304

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1374 rvNDNKTAAEEalrripaINRTIAEAN---EKTR-EAQLALGNAAADATEAKNKAHEAERIASGvqKNATSTKADAERTf 1449
Cdd:NF041483  305 --QRTRTAKEE-------IARLVGEATkeaEALKaEAEQALADARAEAEKLVAEAAEKARTVAA--EDTAAQLAKAART- 372

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1450 sevtdldnevngmlrqleeAENELKRKQDDADQdmmmagMASQAAQEAELNARKAKNSVSSLLSQLTDLLEQLgqldtvd 1529
Cdd:NF041483  373 -------------------AEEVLTKASEDAKA------TTRAAAEEAERIRREAEAEADRLRGEAADQAEQL------- 420

                         490       500       510
                  ....*....|....*....|....*....|....*.
gi 281371490 1530 lnklneiEGSlnkAKDEMKvsDLDRKVSNLENEARK 1565
Cdd:NF041483  421 -------KGA---AKDDTK--EYRAKTVELQEEARR 444
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 340-394 1.31e-04

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 41.18  E-value: 1.31e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 281371490   340 CDCNGR---SQECYFdpelyrstgHGGHCTnCRDNTDGAKCERCRENFFRLGNTEACS 394
Cdd:pfam00053    1 CDCNPHgslSDTCDP---------ETGQCL-CKPGVTGRHCDRCKPGYYGLPSDPPQG 48
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 770-818 1.53e-04

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 40.80  E-value: 1.53e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 281371490  770 PCPCPGGSSCAIVPKTKEVVCtHCPTGTAGKRCELCDDGYFGDPLGSNG 818
Cdd:cd00055     1 PCDCNGHGSLSGQCDPGTGQC-ECKPNTTGRRCDRCAPGYYGLPSQGGG 48
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 284-325 3.27e-04

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 40.03  E-value: 3.27e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 281371490   284 CKCNGHASECVKNEFGKLVCNCKHNTYGVDCEKCLPFFNDRP 325
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLP 42
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 339-387 4.29e-04

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 39.64  E-value: 4.29e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 281371490  339 PCDCNGR---SQECYFdpelyrstgHGGHCTnCRDNTDGAKCERCRENFFRL 387
Cdd:cd00055     1 PCDCNGHgslSGQCDP---------GTGQCE-CKPNTTGRRCDRCAPGYYGL 42
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
284-326 8.91e-03

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 35.75  E-value: 8.91e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 281371490    284 CKCNGHASECVKNEFGKLVCNCKHNTYGVDCEKCLPFFNDRPW 326
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGP 43
 
Name Accession Description Interval E-value
LamNT smart00136
Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related ...
 42-282 5.54e-119

Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related protein such as Unc-6/ netrins.


Pssm-ID: 214532  Cd Length: 238  Bit Score: 373.62  E-value: 5.54e-119
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490     42 GGRPQRCMPEFVNAAFNVTVVATNTCGTP-PEEYCVQTGVTGVTKSCHLCDAGQLHLQHGAAFLTDYNNQADTTWWQSQT 120
Cdd:smart00136    1 AGRPRSCYPPFVNLAFGREVTATSTCGEPgPERYCKLVGHTEQGKKCDYCDARNPRRSHPAENLTDGNNPNNPTWWQSEP 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490    121 MLAGVQYpnsINLTLHLGKAFDITYVRLKFHTSRPeSFAIYKRTREDGPWIPYQYYSGSCENTYSKANRGFIRTGgDEQQ 200
Cdd:smart00136   81 LSNGPQN---VNLTLDLGKEFHVTYVILKFCSPRP-SLWILERSDFGKTWQPWQYFSSDCRRTFGRPPRGPITKG-NEDE 155

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490    201 ALCTDEFSDISPLTGGNVAFSTLEGRPSAYNFDNSPVLQEWVTATDIRVTLNRLNTFGDEVFND-PKVLKSYYYAISDFA 279
Cdd:smart00136  156 VICTSEYSDIVPLEGGEIAFSLLEGRPSATDFDNSPVLQEWVTATNIRVRLTRLRTLGDELMDDrPEVTRRYYYAISDIA 235


                    ...
gi 281371490    280 VGG 282
Cdd:smart00136  236 VGG 238
Laminin_N pfam00055
Laminin N-terminal (Domain VI);
48-282 1.13e-113

Laminin N-terminal (Domain VI);


Pssm-ID: 459653  Cd Length: 230  Bit Score: 358.43  E-value: 1.13e-113
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490    48 CMPEFVNAAFNVTVVATNTCGT-PPEEYCVQTGVTGVtKSCHLCDAGQLHLQHGAAFLTDYNNQADTTWWQSQTMLagVQ 126
Cdd:pfam00055    1 CYPAFGNLAFGREVSATSTCGLnGPERYCILSGLEGG-KKCFICDSRDPHNSHPPSNLTDSNNGTNETWWQSETGV--IQ 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490   127 YPNsINLTLHLGKAFDITYVRLKFHTSRPESFAIYKRTREDGPWIPYQYYSGSCENTYSKANRGfiRTGGDEQQALCTDE 206
Cdd:pfam00055   78 YEN-VNLTLDLGKEFHFTYLILKFKSPRPAAMVLERSTDFGKTWQPYQYFASDCRRTFGRPSGP--SRGIKDDEVICTSE 154

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 281371490   207 FSDISPLTGGNVAFSTLEGRPSAYNFDNSPVLQEWVTATDIRVTLNRLNTFGDEVFNDPKVLKSYYYAISDFAVGG 282
Cdd:pfam00055  155 YSDISPLTGGEVIFSTLEGRPSANIFDYSPELQDWLTATNIRIRLLRLHTLGDELLDDPSVLRKYYYAISDISVGG 230
LamB smart00281
Laminin B domain;
552-676 4.86e-41

Laminin B domain;


Pssm-ID: 214597  Cd Length: 127  Bit Score: 147.41  E-value: 4.86e-41
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490    552 YFPRYFVAPAKFLGNQVLSYGQNLSFSFRVD--RRDTRLSAEDLVLEGAGLRVSVPliAQGNSYPSE-TTVKYIFRLHEA 628
Cdd:smart00281    2 NEPVYWVAPEQFLGDKVTSYGGKLRYTLSFDgrRGGTHVSAPDVILEGNGLRISHP--AEGPPLPDElTTVEVRFREENW 79

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*....
gi 281371490    629 TDYPWRPALSPfEFQKLLNNLTSIKIRGTYSERSAG-YLDDVTLQSARP 676
Cdd:smart00281   80 QYYGGRPVTRE-DLMMVLANLTAILIRATYSQQMAGsRLSDVSLEVAVP 127
Laminin_B pfam00052
Laminin B (Domain IV);
556-686 6.55e-41

Laminin B (Domain IV);


Pssm-ID: 459652  Cd Length: 136  Bit Score: 147.42  E-value: 6.55e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490   556 YFVAPAKFLGNQVLSYGQNLSFSFRVDRRD---TRLSAEDLVLEGAGLRVSVPLIAQGNSYPSETTvKYIFRLHEATdyp 632
Cdd:pfam00052    1 YWSAPEQFLGNKLTSYGGYLTYTVRYEPLPgggSLNSEPDVILEGNGLRLSYSSPDQPPPDPGQEQ-TYSVRLHEEN--- 76

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490   633 WR----PALSPFEFQKLLNNLTSIKIRGTYSERSAG-YLDDVTLQSARPGP-GVPATWVE 686
Cdd:pfam00052   77 WRdsdgAPVSREDFMMVLANLTAILIRATYSTGSGQvSLSNVSLDSAVPGGsGPPASWVE 136
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1034-1596 9.39e-18

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 90.12  E-value: 9.39e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1034 RLVKDKVAEHRVKLQELESLIANLGTGDETVTDQA--FEDRLKEAEREVTDLLREAQEV-------KDVDQNLMDRLQRV 1104
Cdd:TIGR02168  429 KLEEAELKELQAELEELEEELEELQEELERLEEALeeLREELEEAEQALDAAERELAQLqarldslERLQENLEGFSEGV 508

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1105 NNSLHSQiSRLHNIrntieeTGILAERARSRvESTEQLIEIASREL------EKAKMAAANVSITQPESTG--------- 1169
Cdd:TIGR02168  509 KALLKNQ-SGLSGI------LGVLSELISVD-EGYEAAIEAALGGRlqavvvENLNAAKKAIAFLKQNELGrvtflplds 580

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1170 ------EPNNMTLLAEE--ARRLAERHKQEADDI----------VRVAK---TANETSAE-AYNLLLRTLAGE------- 1220
Cdd:TIGR02168  581 ikgteiQGNDREILKNIegFLGVAKDLVKFDPKLrkalsyllggVLVVDdldNALELAKKlRPGYRIVTLDGDlvrpggv 660

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1221 --------NQTAL----EIEELNRKYEQAKNISQDLEKQAARV---HEEAKRAGDKAVEIYASVAQLTPVDSEALESEAN 1285
Cdd:TIGR02168  661 itggsaktNSSILerrrEIEELEEKIEELEEKIAELEKALAELrkeLEELEEELEQLRKELEELSRQISALRKDLARLEA 740

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1286 KIKKEAADLDRLiDQKLKDYEDLREDMRGKEHEVKNLLEKGKAEQQTADQLLARADAAKALAeeaakkgRNTLQEANDIL 1365
Cdd:TIGR02168  741 EVEQLEERIAQL-SKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKAL-------REALDELRAEL 812

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1366 NNLKdfdRRVNDNKTAAEEALRRIPAINRTIAEANEKTREAQLALGNAAA---DATEAKNKAHEaERIASGVQKNATSTK 1442
Cdd:TIGR02168  813 TLLN---EEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAeieELEELIEELES-ELEALLNERASLEEA 888

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1443 ADAERtfSEVTDLDNEVNGMLRQLEEAENELKRKQDDADQ--------DMMMAGMASQAAQEAELNARKAKNSVSSLLS- 1513
Cdd:TIGR02168  889 LALLR--SELEELSEELRELESKRSELRRELEELREKLAQlelrleglEVRIDNLQERLSEEYSLTLEEAEALENKIEDd 966

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1514 ------QLTDLLEQLGQLDTVDLNKLNEIEgSLNKAKDEMK--VSDLdrkvsnleNEARKQ-EAAILDYDRDIAEIIKDI 1584
Cdd:TIGR02168  967 eeearrRLKRLENKIKELGPVNLAAIEEYE-ELKERYDFLTaqKEDL--------TEAKETlEEAIEEIDREARERFKDT 1037

                          650
                   ....*....|..
gi 281371490  1585 hnLEDIKKTLPT 1596
Cdd:TIGR02168 1038 --FDQVNENFQR 1047
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1070-1594 1.68e-16

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 85.50  E-value: 1.68e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1070 EDRLKEAEREVTDLLREAQEVKDVDQNLMDRLQRVNnslhSQISRLHNIRNTIEETGILAERARSRVESTEQLI-EIASR 1148
Cdd:PRK03918  192 EELIKEKEKELEEVLREINEISSELPELREELEKLE----KEVKELEELKEEIEELEKELESLEGSKRKLEEKIrELEER 267

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1149 ------ELEKAKmaaanvsitqpESTGEPNNMTLLAEEARRLAERHKQEADDIVRVAKTANETSAEAYNLLLRTLAGENQ 1222
Cdd:PRK03918  268 ieelkkEIEELE-----------EKVKELKELKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEK 336

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1223 TAlEIEELNRKYEQAKNISQDLEKQaARVHEEAKRAGDKAVEIYASVAQLTPVDSEA-----------LESEANKIKKEA 1291
Cdd:PRK03918  337 EE-RLEELKKKLKELEKRLEELEER-HELYEEAKAKKEELERLKKRLTGLTPEKLEKeleelekakeeIEEEISKITARI 414

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1292 ADLDRLIDQKLKDYEDLREdMRGK---------EHEVKNLLEKGKAEQQTAdqllaradaakalaeeaakkgRNTLQEAN 1362
Cdd:PRK03918  415 GELKKEIKELKKAIEELKK-AKGKcpvcgreltEEHRKELLEEYTAELKRI---------------------EKELKEIE 472

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1363 DILNNLKDFDRRVnDNKTAAEEALRRIPAINRTIAEANEKTREaqlalgnaaADATEAKNKAHEAERI---ASGVQKNAT 1439
Cdd:PRK03918  473 EKERKLRKELREL-EKVLKKESELIKLKELAEQLKELEEKLKK---------YNLEELEKKAEEYEKLkekLIKLKGEIK 542

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1440 STKADAERTfsevtdldNEVNGMLRQLEEAENELKRKQDDADQDMMMAGMASqaaqEAELNAR------------KAKNS 1507
Cdd:PRK03918  543 SLKKELEKL--------EELKKKLAELEKKLDELEEELAELLKELEELGFES----VEELEERlkelepfyneylELKDA 610

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1508 VSSLLSQL-------TDLLEQLGQLDTVDlNKLNEIEGSLNKAK---DEMKVSDLDRKVSNLENEARKQEAAILDYDRDI 1577
Cdd:PRK03918  611 EKELEREEkelkkleEELDKAFEELAETE-KRLEELRKELEELEkkySEEEYEELREEYLELSRELAGLRAELEELEKRR 689

                         570
                  ....*....|....*..
gi 281371490 1578 AEIIKDIHNLEDIKKTL 1594
Cdd:PRK03918  690 EEIKKTLEKLKEELEER 706
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1070-1588 1.36e-14

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 79.34  E-value: 1.36e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1070 EDRLKEAEREVTDLLREAQEVKDVDQNLMDRLQRVNNSLHSQISRLHNIRNTIEETGILAERARSRVESTEQLIE-IASR 1148
Cdd:PRK03918  164 YKNLGEVIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVKELEELKEeIEEL 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1149 ELEKAKmaaanvsitqpestgepnnmtlLAEEARRLAERHKQEADDIVRVAKTANETSAEAYNllLRTLAGENQTALEIE 1228
Cdd:PRK03918  244 EKELES----------------------LEGSKRKLEEKIRELEERIEELKKEIEELEEKVKE--LKELKEKAEEYIKLS 299

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1229 ELNRKYEQAKNisqDLEKQAARVHEEAKragdkavEIYASVAQLtpvdsEALESEANKIKKEAADLDRLIdQKLKDYEDL 1308
Cdd:PRK03918  300 EFYEEYLDELR---EIEKRLSRLEEEIN-------GIEERIKEL-----EEKEERLEELKKKLKELEKRL-EELEERHEL 363

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1309 REDMRGKEHEVKNL--------LEKGKAEQQTADQLlaradaakalaeeaakkgRNTLQEA-NDILNNLKDFDRRVNDNK 1379
Cdd:PRK03918  364 YEEAKAKKEELERLkkrltgltPEKLEKELEELEKA------------------KEEIEEEiSKITARIGELKKEIKELK 425

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1380 TAAEE---ALRRIPAINRTIAEANEKT--REAQLALGNAAADATEAKNKAHEAERIASGVQK--NATSTKADAERTFSEV 1452
Cdd:PRK03918  426 KAIEElkkAKGKCPVCGRELTEEHRKEllEEYTAELKRIEKELKEIEEKERKLRKELRELEKvlKKESELIKLKELAEQL 505

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1453 TDLDNEVNGM-LRQLEEAENE---LKRKQDDADQDmmMAGMASQAAQEAELNARKA-----KNSVSSLLSQLTDLLEQLG 1523
Cdd:PRK03918  506 KELEEKLKKYnLEELEKKAEEyekLKEKLIKLKGE--IKSLKKELEKLEELKKKLAelekkLDELEEELAELLKELEELG 583

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 281371490 1524 QLDTVDLN-KLNEIEG------SLNKAKDEMKvsDLDRKVSNLENEARKQEAAILDYDRDIAEIIKDIHNLE 1588
Cdd:PRK03918  584 FESVEELEeRLKELEPfyneylELKDAEKELE--REEKELKKLEEELDKAFEELAETEKRLEELRKELEELE 653
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
933-978 3.34e-14

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 68.11  E-value: 3.34e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 281371490    933 CDCHALGSTNGQCDIRTGQCECQPGITGQHCERCETNHFGFGPEGC 978
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 1038-1592 4.48e-14

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 77.45  E-value: 4.48e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1038 DKVAEHRVKLQELESLIANLGTGDETVTdQAFEDRLKEAEREVTDLLREAQEVKDVDQNLMDRLQRVNNSLHSQISRL-- 1115
Cdd:pfam05483  169 EKTKKYEYEREETRQVYMDLNNNIEKMI-LAFEELRVQAENARLEMHFKLKEDHEKIQHLEEEYKKEINDKEKQVSLLli 247

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1116 --HNIRNTIEETGILAERARSRV-----------ESTEQLIEIA---SRELEKAKMAAANVSITQPESTGEPNNMT---- 1175
Cdd:pfam05483  248 qiTEKENKMKDLTFLLEESRDKAnqleektklqdENLKELIEKKdhlTKELEDIKMSLQRSMSTQKALEEDLQIATktic 327

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1176 -LLAEEARRLAERHKQEADDIVRVakTANETSAEAYNLLLRTlagenqtalEIEELNRKYEQAKNISQDLEKQAARVHEE 1254
Cdd:pfam05483  328 qLTEEKEAQMEELNKAKAAHSFVV--TEFEATTCSLEELLRT---------EQQRLEKNEDQLKIITMELQKKSSELEEM 396

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1255 AKRAGDKAVEIyasvaqltpvdsealeseaNKIKKEAADLDRLIDQKlKDYEDLREDMRGKEHEVKNLLEKGKAEqqtad 1334
Cdd:pfam05483  397 TKFKNNKEVEL-------------------EELKKILAEDEKLLDEK-KQFEKIAEELKGKEQELIFLLQAREKE----- 451

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1335 qllaradaakalaeeaakkgrntlqeandilnnLKDFDRRVNDNKTAAEEALRRIPAINRTIAeaNEKTREAQLAlGNAA 1414
Cdd:pfam05483  452 ---------------------------------IHDLEIQLTAIKTSEEHYLKEVEDLKTELE--KEKLKNIELT-AHCD 495

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1415 ADATEAKNKAHEAERIASGV---QKNATSTKADAERTFSEVTDLDNEVNGMLRQLEEAENELKRKQDDA----DQDMMMA 1487
Cdd:pfam05483  496 KLLLENKELTQEASDMTLELkkhQEDIINCKKQEERMLKQIENLEEKEMNLRDELESVREEFIQKGDEVkcklDKSEENA 575

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1488 GMASQAAQEAELNARKAKNSVSSLLSQLTD---LLEQLGQLDTVDLNKLNEIEGSLNKAkdEMKVSDLDRKvsnLENEAR 1564
Cdd:pfam05483  576 RSIEYEVLKKEKQMKILENKCNNLKKQIENknkNIEELHQENKALKKKGSAENKQLNAY--EIKVNKLELE---LASAKQ 650

                          570       580       590
                   ....*....|....*....|....*....|.
gi 281371490  1565 KQEAAILDYDRDIAeiIKDIHN---LEDIKK 1592
Cdd:pfam05483  651 KFEEIIDNYQKEIE--DKKISEeklLEEVEK 679
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 443-490 7.47e-14

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 66.99  E-value: 7.47e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 281371490   443 CSCDPSGS-TDECNVETGRCVCKDNVEGFSCERCKPGFFNLESSNPKGC 490
Cdd:pfam00053    1 CDCNPHGSlSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 932-979 2.64e-13

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 65.45  E-value: 2.64e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 281371490  932 SCDCHALGSTNGQCDIRTGQCECQPGITGQHCERCETNHFGF--GPEGCK 979
Cdd:cd00055     1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLpsQGGGCQ 50
PTZ00121 PTZ00121
MAEBL; Provisional
 1071-1567 4.36e-13

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 74.79  E-value: 4.36e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1071 DRLKEAE-REVTDLLREAQEVKDVDQnLMDRLQRVNNSLHSQiSRLHNIRNTIEETGILAERARSRVESTEQLIEIASRE 1149
Cdd:PTZ00121 1281 DELKKAEeKKKADEAKKAEEKKKADE-AKKKAEEAKKADEAK-KKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADE 1358

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1150 LEKAKMAAANVSITQPESTGEPNNMTLLAEEARRL------AERHKQEADDIVRVA---KTANETSAEAYNLL----LRT 1216
Cdd:PTZ00121 1359 AEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKAdeakkkAEEDKKKADELKKAAaakKKADEAKKKAEEKKkadeAKK 1438

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1217 LAGENQTAleiEELNRKYEQAKNiSQDLEKQA--ARVHEEAKRAGD---KAVEIYASVAQLTPVDSEALESEANKIK--- 1288
Cdd:PTZ00121 1439 KAEEAKKA---DEAKKKAEEAKK-AEEAKKKAeeAKKADEAKKKAEeakKADEAKKKAEEAKKKADEAKKAAEAKKKade 1514

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1289 ------KEAADLDRLIDQKLKDYEDLREDMRGKEHEVKNLLEKGKAEQQTADQLLARADAAKALAEEAAKKGRNTLQEAN 1362
Cdd:PTZ00121 1515 akkaeeAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARI 1594

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1363 DILNNLKDFD--------RRVNDNKTAA------EEALRRIPAINRTIAEANEKTREAQLALGNAAADATEAKNKAHEAE 1428
Cdd:PTZ00121 1595 EEVMKLYEEEkkmkaeeaKKAEEAKIKAeelkkaEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDK 1674

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1429 RIASGVQKNATSTKADAERTFSEvtdldNEVNGMLRQLEEAENELKRKQDDADQ-DMMMAGMASQAAQEAELNARKA--- 1504
Cdd:PTZ00121 1675 KKAEEAKKAEEDEKKAAEALKKE-----AEEAKKAEELKKKEAEEKKKAEELKKaEEENKIKAEEAKKEAEEDKKKAeea 1749

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1505 ------KNSVSSLLSqltdllEQLGQLDTVDLNKLNEIEGSLNKaKDEMKVSDLDRKVSNL-ENEARKQE 1567
Cdd:PTZ00121 1750 kkdeeeKKKIAHLKK------EEEKKAEEIRKEKEAVIEEELDE-EDEKRRMEVDKKIKDIfDNFANIIE 1812
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1038-1594 4.38e-13

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 74.72  E-value: 4.38e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1038 DKVAEHRVKLQELESLIANLGtGDETVtdqAFEDRLKEAEREVTDLLREAQEVKDVDQNLMDRLQRVNNSLHSQISRLHN 1117
Cdd:TIGR02169  265 KRLEEIEQLLEELNKKIKDLG-EEEQL---RVKEKIGELEAEIASLERSIAEKERELEDAEERLAKLEAEIDKLLAEIEE 340

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1118 IRNTIEETGILAERARSRVESTEQLIEIASRELE---------KAKMAAANVSITQPESTGEPNNMTL--LAEEARRLAE 1186
Cdd:TIGR02169  341 LEREIEEERKRRDKLTEEYAELKEELEDLRAELEevdkefaetRDELKDYREKLEKLKREINELKRELdrLQEELQRLSE 420

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1187 R---HKQEADDIvRVAKTANETSAEAYNLLLRTLAGENQTALEI-EELNRKYEQAKNISQDLEKQAARVHEEAKRA---- 1258
Cdd:TIGR02169  421 EladLNAAIAGI-EAKINELEEEKEDKALEIKKQEWKLEQLAADlSKYEQELYDLKEEYDRVEKELSKLQRELAEAeaqa 499

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1259 --------GDKAVE---------IYASVAQLTPVDSE---ALESEA-----NKIKKEAADLDRLIdQKLKDYEDLR---- 1309
Cdd:TIGR02169  500 raseervrGGRAVEevlkasiqgVHGTVAQLGSVGERyatAIEVAAgnrlnNVVVEDDAVAKEAI-ELLKRRKAGRatfl 578

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1310 --EDMRGKEHEVKNLLEKGkaeqqtadqllaradaakalaeeaakkgrntlqeANDILNNLKDFDRR------------- 1374
Cdd:TIGR02169  579 plNKMRDERRDLSILSEDG----------------------------------VIGFAVDLVEFDPKyepafkyvfgdtl 624

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1375 -VNDNKTAaeealRRIPAINRTIAEANEKTREAQLALGNAAADATEAKNKAHEAERIASgVQKNATSTKADAERTFSEVT 1453
Cdd:TIGR02169  625 vVEDIEAA-----RRLMGKYRMVTLEGELFEKSGAMTGGSRAPRGGILFSRSEPAELQR-LRERLEGLKRELSSLQSELR 698

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1454 DLDNEVNGMLRQLEEAENELKRKQDDadqdmmmagmASQAAQEAELNARKAKNSVSSL--LSQ--------LTDLLEQLG 1523
Cdd:TIGR02169  699 RIENRLDELSQELSDASRKIGEIEKE----------IEQLEQEEEKLKERLEELEEDLssLEQeienvkseLKELEARIE 768

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 281371490  1524 QLdTVDLNKLNEIEGSLNKAKDEMKVSDLDRKVSNLENEARKQEAAILDYDRDIAEIIKDIHNLEDIKKTL 1594
Cdd:TIGR02169  769 EL-EEDLHKLEEALNDLEARLSHSRIPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQEL 838
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 933-981 5.98e-13

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 64.68  E-value: 5.98e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 281371490   933 CDCHALGSTNGQCDIRTGQCECQPGITGQHCERCETNHFGFGPEGCKPC 981
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 396-443 4.17e-12

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 62.37  E-value: 4.17e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 281371490   396 CHCSPVGSLSTQCDSY-GRCSCKPGVMGDKCDRCQPGFHSLTEAGCRPC 443
Cdd:pfam00053    1 CDCNPHGSLSDTCDPEtGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
PTZ00121 PTZ00121
MAEBL; Provisional
 1062-1592 5.27e-12

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 71.33  E-value: 5.27e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1062 ETVTDQAFEDRLKEAEREVTDLLREAQEVKDV-DQNLMDRLQRVNNSLHSQISRLHNIRNTIEETGiLAERARsRVESTE 1140
Cdd:PTZ00121 1105 KTETGKAEEARKAEEAKKKAEDARKAEEARKAeDARKAEEARKAEDAKRVEIARKAEDARKAEEAR-KAEDAK-KAEAAR 1182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1141 QLIEI-ASRELEKAKMAAANVSITQPESTGEPNNMTLlAEEARRL-----AERHKQEADDIVRVAKTANETSAEAYNLLL 1214
Cdd:PTZ00121 1183 KAEEVrKAEELRKAEDARKAEAARKAEEERKAEEARK-AEDAKKAeavkkAEEAKKDAEEAKKAEEERNNEEIRKFEEAR 1261

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1215 RTLAGENQTALEIEElNRKYEQAKNISQDLEKQAARVHEEAKRAGD---KAVEiyasvaqltPVDSEALESEANKIKKEA 1291
Cdd:PTZ00121 1262 MAHFARRQAAIKAEE-ARKADELKKAEEKKKADEAKKAEEKKKADEakkKAEE---------AKKADEAKKKAEEAKKKA 1331

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1292 ADLDRLIDQKLKDYEDLREDMRGKEHEVKNLLEKGKAEQQTADQLLARADAAKalaeeaakkgrntlQEANDIlNNLKDF 1371
Cdd:PTZ00121 1332 DAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAK--------------KKAEEK-KKADEA 1396

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1372 DRRVNDNKTAAEEaLRRIPAINRTIAEANEKTREAQlalgnaaaDATEAKNKAHEAERIASGVQKNATSTKADAERTFSE 1451
Cdd:PTZ00121 1397 KKKAEEDKKKADE-LKKAAAAKKKADEAKKKAEEKK--------KADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAE 1467

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1452 VTDLDNEVNGMLRQLEEAEnELKRKQDDADQDMMMAGMASQAAQEAE-----LNARKAKNSVSSLLSQLTDLLEQLGQLD 1526
Cdd:PTZ00121 1468 EAKKADEAKKKAEEAKKAD-EAKKKAEEAKKKADEAKKAAEAKKKADeakkaEEAKKADEAKKAEEAKKADEAKKAEEKK 1546

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 281371490 1527 TVD-LNKLNEIEGSLNKAKDEMKVSDLDRKVSNLE--NEARKQEAAILDYDRDIAEIIKDIhNLEDIKK 1592
Cdd:PTZ00121 1547 KADeLKKAEELKKAEEKKKAEEAKKAEEDKNMALRkaEEAKKAEEARIEEVMKLYEEEKKM-KAEEAKK 1614
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 722-761 6.48e-12

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 61.60  E-value: 6.48e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 281371490   722 CTCNGH---SETCDPETGVCDCRDNTAGPHCEKCSDGYYGDST 761
Cdd:pfam00053    1 CDCNPHgslSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPS 43
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1033-1592 8.82e-12

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 70.35  E-value: 8.82e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1033 YRLVKD--KVAEHRVKLQELESLIANLgtgdetvtdQAFEDRLKEAEREVTDLLREAQEVKDVDQNLMDRLQRVNNSLHS 1110
Cdd:COG1196   215 YRELKEelKELEAELLLLKLRELEAEL---------EELEAELEELEAELEELEAELAELEAELEELRLELEELELELEE 285

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1111 QISRLHNIRNTIEEtgilAERARSRVEstEQLIEIASRELEkakmaaanvsitqpestgepnnmtlLAEEARRLAERHKQ 1190
Cdd:COG1196   286 AQAEEYELLAELAR----LEQDIARLE--ERRRELEERLEE-------------------------LEEELAELEEELEE 334

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1191 EADDIVRVAKTANETSAEaynlllrtlagENQTALEIEELNRKYEQAKNISQDLEKQAARVHEEAKRAGDKAVEIYASVA 1270
Cdd:COG1196   335 LEEELEELEEELEEAEEE-----------LEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLE 403

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1271 QLTPVDS------EALESEANKIKKEAADLDRLIDQKLKDYEDLREDMRGKEHEVKNLLEKGKAEQQTADQLLARADAAK 1344
Cdd:COG1196   404 ELEEAEEallerlERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELL 483

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1345 ALAEEAAKKgRNTLQEANDILNNLKDFDRRVNDNK--------------------TAAEEAL-RRIPAINRTIAEANEKT 1403
Cdd:COG1196   484 EELAEAAAR-LLLLLEAEADYEGFLEGVKAALLLAglrglagavavligveaayeAALEAALaAALQNIVVEDDEVAAAA 562

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1404 RE--AQLALGNA------AADATEAKNKAHEAERIASGVQKNATSTKADAERTF-----SEVTDLDNEVNGMLRQLEEAE 1470
Cdd:COG1196   563 IEylKAAKAGRAtflpldKIRARAALAAALARGAIGAAVDLVASDLREADARYYvlgdtLLGRTLVAARLEAALRRAVTL 642

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1471 NELKRKQDDADQDMMMAGMASQAAQEAELNARKAKNSVSSLLSQLTDLLEQLGQLDTVDLNKLNEIEGSLNKAKDEMKVS 1550
Cdd:COG1196   643 AGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELE 722

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|..
gi 281371490 1551 DLDRKVSNLENEARKQEAAILDYDRDIAEIIKDIHNLEDIKK 1592
Cdd:COG1196   723 EEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEE 764
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 722-769 9.07e-12

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 61.22  E-value: 9.07e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 281371490  722 CTCNGH---SETCDPETGVCDCRDNTAGPHCEKCSDGYYGDSTLGTssDCQ 769
Cdd:cd00055     2 CDCNGHgslSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGG--GCQ 50
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1034-1535 9.21e-12

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 70.35  E-value: 9.21e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1034 RLVKDKVAEHRVKLQELESLIANLgtgdeTVTDQAFEDRLKEAEREVTDLLREAQEVKDVDQNLMDRLQRVNNSLHSQIS 1113
Cdd:COG1196   305 ARLEERRRELEERLEELEEELAEL-----EEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEE 379

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1114 RLHNIRNTIEEtgILAERARSRVESTEQLIEIASRELEKAKMAAANVSITQPESTGEpnnmTLLAEEARRLAERHKQEAD 1193
Cdd:COG1196   380 ELEELAEELLE--ALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELE----EEEEEEEEALEEAAEEEAE 453

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1194 DIVRVAKTANETSAEAYNLLLRTLAGENQTALEIEELNRKY--EQAKNISQDLEKQAARVHEEAKRA---GDKAVEIYAS 1268
Cdd:COG1196   454 LEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLllLEAEADYEGFLEGVKAALLLAGLRglaGAVAVLIGVE 533

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1269 VAQLTPVDSEALESEANKIKKEAADLDRLID------------------------QKLKDYEDLREDMRGKEHEVKNLLE 1324
Cdd:COG1196   534 AAYEAALEAALAAALQNIVVEDDEVAAAAIEylkaakagratflpldkiraraalAAALARGAIGAAVDLVASDLREADA 613

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1325 KGKAEQQT---ADQLLARADAAKALAEEAAKKGRNTLQEANDILNNLKDFDRRVNDNKTAAEEALRRIPAINRTIAEANE 1401
Cdd:COG1196   614 RYYVLGDTllgRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEEL 693

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1402 KTREAQLALGNAAADATEAKNKAHEAERIASGVQKNATSTKADAERTFSEVTDLDNEVNGM-------LRQLEEAENELK 1474
Cdd:COG1196   694 ELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEelpeppdLEELERELERLE 773

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 281371490 1475 RKqddadqdMMMAG---MAsqAAQE-AELNARKAknsvsSLLSQLTDLLEQLGQLDTVdLNKLNE 1535
Cdd:COG1196   774 RE-------IEALGpvnLL--AIEEyEELEERYD-----FLSEQREDLEEARETLEEA-IEEIDR 823
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 442-491 1.14e-11

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 60.83  E-value: 1.14e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 281371490  442 PCSCDPSGS-TDECNVETGRCVCKDNVEGFSCERCKPGFFNLeSSNPKGCT 491
Cdd:cd00055     1 PCDCNGHGSlSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGL-PSQGGGCQ 50
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1037-1594 1.52e-11

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 69.70  E-value: 1.52e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1037 KDKVAEHRVKLQELESLIanlgtgdetvtdQAFEDRLKEAEREVTDLLREAQEVkdvdQNLMDRLQRVNNSLHSQISRlh 1116
Cdd:TIGR02168  336 AEELAELEEKLEELKEEL------------ESLEAELEELEAELEELESRLEEL----EEQLETLRSKVAQLELQIAS-- 397

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1117 nIRNTIEETGILAERARSRVESTEQLIEIASRELEKAKMAAANVSItqpestgepnnmtllaEEARRLAERHKQEADDIV 1196
Cdd:TIGR02168  398 -LNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAEL----------------EELEEELEELQEELERLE 460

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1197 RVAKTANETSAEAYNLLLRTLAGENQTALEIEELNRKYEQAKNISQD---LEKQAARVHEEAKRAGD---------KAVE 1264
Cdd:TIGR02168  461 EALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGvkaLLKNQSGLSGILGVLSElisvdegyeAAIE 540

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1265 IY--ASVAQLTPVDSEALESEANKIKKEAAD------LDRLIDQKLK-DYEDLREDMRGKEhEVKNLLEKGKAEQQTADQ 1335
Cdd:TIGR02168  541 AAlgGRLQAVVVENLNAAKKAIAFLKQNELGrvtflpLDSIKGTEIQgNDREILKNIEGFL-GVAKDLVKFDPKLRKALS 619

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1336 llaradaakalaeeaAKKGR----NTLQEANDILNNLK-----------------------------DFDRRVN--DNKT 1380
Cdd:TIGR02168  620 ---------------YLLGGvlvvDDLDNALELAKKLRpgyrivtldgdlvrpggvitggsaktnssILERRREieELEE 684

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1381 AAEEALRRIPAINRTIAEANEKTREAQLALGNAAADATEAKNKAHEAERIASGVQKNATSTKADAERTFSEVTDLDNEVN 1460
Cdd:TIGR02168  685 KIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIE 764

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1461 GMLRQLEEAENELKRKQDDadqdmmmagmasQAAQEAELNarKAKNSVSSLLSQLTDLLEQLGQLDTVDLNKLNEIEGSL 1540
Cdd:TIGR02168  765 ELEERLEEAEEELAEAEAE------------IEELEAQIE--QLKEELKALREALDELRAELTLLNEEAANLRERLESLE 830

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 281371490  1541 NKAKDEMK-VSDLDRKVSNLENEARKQEAAILDYDRDIAEIIKDIHNLEDIKKTL 1594
Cdd:TIGR02168  831 RRIAATERrLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASL 885
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 395-441 1.70e-11

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 60.45  E-value: 1.70e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 281371490  395 PCHCSPVGSLSTQCDSY-GRCSCKPGVMGDKCDRCQPGFHSLTEA--GCR 441
Cdd:cd00055     1 PCDCNGHGSLSGQCDPGtGQCECKPNTTGRRCDRCAPGYYGLPSQggGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 882-930 2.07e-11

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 60.06  E-value: 2.07e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 281371490   882 CACNPYGTVQqqSSCNPVTGQCQCLPHVSGRDCGACDPGFYNLQ--SGQGC 930
Cdd:pfam00053    1 CDCNPHGSLS--DTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPsdPPQGC 49
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1034-1521 2.28e-11

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 68.64  E-value: 2.28e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1034 RLVKDKVAEHRVKLQELESLIANLGTGDETVTD-QAFEDRLKEAEREVTDLlREAQEVKDVDQNLMDRLQRvnnsLHSQI 1112
Cdd:COG4717    57 ELFKPQGRKPELNLKELKELEEELKEAEEKEEEyAELQEELEELEEELEEL-EAELEELREELEKLEKLLQ----LLPLY 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1113 SRLHNIRNTIEETGILAERARSRVESTEQLI-EIASRELEKAKMAAANVSITQPESTGEPNNMTLLAEEARRLAERhKQE 1191
Cdd:COG4717   132 QELEALEAELAELPERLEELEERLEELRELEeELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQR-LAE 210

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1192 ADDIVRVAKTANETSAEAYNLLlrtlagenQTALEIEELNRKYEQAKNISQDLekqAARVHEEAKRAGDKAVEIY----- 1266
Cdd:COG4717   211 LEEELEEAQEELEELEEELEQL--------ENELEAAALEERLKEARLLLLIA---AALLALLGLGGSLLSLILTiagvl 279

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1267 ASVAQLTPVDSEALESEANKIKKEAADLD------RLIDQKLKDY-EDLREDMRGKEHEVKNLLEKGKAEQQTADQllar 1339
Cdd:COG4717   280 FLVLGLLALLFLLLAREKASLGKEAEELQalpaleELEEEELEELlAALGLPPDLSPEELLELLDRIEELQELLRE---- 355

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1340 adaakalaeeaakkgRNTLQEANDILNNLKDFDRRVNDNKTAAEEALRRIPAINRTIAEANEKTREAQLALgNAAADATE 1419
Cdd:COG4717   356 ---------------AEELEEELQLEELEQEIAALLAEAGVEDEEELRAALEQAEEYQELKEELEELEEQL-EELLGELE 419

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1420 AKNKAHEAERIasgvqknatstKADAERTFSEVTDLDNEVNGMLRQLEEAENELKRKQDDADQDMMMAGMASQAAQEAEL 1499
Cdd:COG4717   420 ELLEALDEEEL-----------EEELEELEEELEELEEELEELREELAELEAELEQLEEDGELAELLQELEELKAELREL 488

                         490       500
                  ....*....|....*....|...
gi 281371490 1500 NARKAKNSV-SSLLSQLTDLLEQ 1521
Cdd:COG4717   489 AEEWAALKLaLELLEEAREEYRE 511
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1111-1544 2.40e-11

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 68.81  E-value: 2.40e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1111 QISRL-----HNIRNTIEET-GILA-----ERARSRVESTEQLIEIAS---RELEKakmaaanvsitqpestgepnNMTL 1176
Cdd:COG1196   145 MIDRIieakpEERRAIIEEAaGISKykerkEEAERKLEATEENLERLEdilGELER--------------------QLEP 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1177 LAEEARRlAERHKQeaddivrVAKTANETSAEAYnlllrtlagenqtALEIEELNRKYEQAKNISQDLEKQAARVHEEAk 1256
Cdd:COG1196   205 LERQAEK-AERYRE-------LKEELKELEAELL-------------LLKLRELEAELEELEAELEELEAELEELEAEL- 262

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1257 ragdkaveiyasvaqltpvdsEALESEANKIKKEAADLDRLIDQKLKDYEDLREDMRGKEHEVKNLLEKGKAEQQTADQl 1336
Cdd:COG1196   263 ---------------------AELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEE- 320

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1337 laradaakalaeeaakkgrntLQEANDILnnlkdfdrrvndnKTAAEEALRRIPAINRTIAEANEKTREAQLALGNAAAD 1416
Cdd:COG1196   321 ---------------------LEEELAEL-------------EEELEELEEELEELEEELEEAEEELEEAEAELAEAEEA 366

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1417 ATEAKNKAHEAERIASGVQKNATSTKADAERTFSEVTDLDNEVNGMLRQLEEAENELKRKQDDADQdmmmAGMASQAAQE 1496
Cdd:COG1196   367 LLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAE----LEEEEEEEEE 442

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
gi 281371490 1497 AELNARKAKNSVSSLLSQLTDLLEQLGQLDTVDLNKLNEIEGSLNKAK 1544
Cdd:COG1196   443 ALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAA 490
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
396-440 2.88e-11

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 59.63  E-value: 2.88e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 281371490    396 CHCSPVGSLSTQCDS-YGRCSCKPGVMGDKCDRCQPGFHSLTEAGC 440
Cdd:smart00180    1 CDCDPGGSASGTCDPdTGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 1042-1325 3.20e-11

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 68.23  E-value: 3.20e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1042 EHRVKLQELESLIANLGTGDETVTDQafEDRLKEAEREVTDLLREAQEVKDVDQNL--MDRLQRVNNSLHSQISRLhniR 1119
Cdd:pfam05557  143 LLKAKASEAEQLRQNLEKQQSSLAEA--EQRIKELEFEIQSQEQDSEIVKNSKSELarIPELEKELERLREHNKHL---N 217

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1120 NTIEETGILAERA---RSRVESTEQL-IEIASRELEKAKMAAanvSITQPESTGEPNNMTLLAEEArrLAERHKQ-EADD 1194
Cdd:pfam05557  218 ENIENKLLLKEEVedlKRKLEREEKYrEEAATLELEKEKLEQ---ELQSWVKLAQDTGLNLRSPED--LSRRIEQlQQRE 292

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1195 IVRVA-KTANETSAEAYNLLLRTLAGENQTAL-EIEELNRKYEQAKNISQDLEKQAARVHEEakRAGDKA-VEIYasvaq 1271
Cdd:pfam05557  293 IVLKEeNSSLTSSARQLEKARRELEQELAQYLkKIEDLNKKLKRHKALVRRLQRRVLLLTKE--RDGYRAiLESY----- 365

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....
gi 281371490  1272 ltpvDSEALESEANKIKKEaadldrlidqKLKDYEDLREDMRGKEHEVKNLLEK 1325
Cdd:pfam05557  366 ----DKELTMSNYSPQLLE----------RIEEAEDMTQKMQAHNEEMEAQLSV 405
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
443-490 4.05e-11

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 59.25  E-value: 4.05e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 281371490    443 CSCDPSGS-TDECNVETGRCVCKDNVEGFSCERCKPGFFNlesSNPKGC 490
Cdd:smart00180    1 CDCDPGGSaSGTCDPDTGQCECKPNVTGRRCDRCAPGYYG---DGPPGC 46
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 881-931 7.21e-11

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 58.90  E-value: 7.21e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 281371490  881 ACACNPYGTVQQQssCNPVTGQCQCLPHVSGRDCGACDPGFYNLQS-GQGCE 931
Cdd:cd00055     1 PCDCNGHGSLSGQ--CDPGTGQCECKPNTTGRRCDRCAPGYYGLPSqGGGCQ 50
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 1046-1584 1.24e-10

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 66.68  E-value: 1.24e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1046 KLQELESLIANLGTgDETVTDQAFEDRLKEAER-------EVTDLLREAQEVKDVDQNLMDRLQRVNNSLHSQISRL--- 1115
Cdd:pfam15921  318 QLSDLESTVSQLRS-ELREAKRMYEDKIEELEKqlvlansELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELsle 396

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1116 --HNIRNTIEETG--ILAERARS-------RVESTEQLIEIASRELE---KAKMAA---ANVSI-------TQPESTGEp 1171
Cdd:pfam15921  397 keQNKRLWDRDTGnsITIDHLRRelddrnmEVQRLEALLKAMKSECQgqmERQMAAiqgKNESLekvssltAQLESTKE- 475

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1172 nNMTLLAEE--ARRLAERHKQEADDIVRVAKTANETSAEAYNLLLRTLAGENQTAL-EIEELNRKYEQAKNISQDLEkqA 1248
Cdd:pfam15921  476 -MLRKVVEEltAKKMTLESSERTVSDLTASLQEKERAIEATNAEITKLRSRVDLKLqELQHLKNEGDHLRNVQTECE--A 552

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1249 ARVHEEAKragDKAVEIY-ASVAQLTPVDSE------ALESEANKIKKEAADlDRLIDQKLKDYEDLRE-DMRGKEHEVK 1320
Cdd:pfam15921  553 LKLQMAEK---DKVIEILrQQIENMTQLVGQhgrtagAMQVEKAQLEKEIND-RRLELQEFKILKDKKDaKIRELEARVS 628

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1321 NL-LEKGKAEQQTADQLLARadaakalaeeaakkgRNTLQEANDILNNLKDFDRRVNdNKTAAEEALRRipAINRTIAEA 1399
Cdd:pfam15921  629 DLeLEKVKLVNAGSERLRAV---------------KDIKQERDQLLNEVKTSRNELN-SLSEDYEVLKR--NFRNKSEEM 690

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1400 NEKTREAQLALGNAAADATEAKN--KAHE-----AERIASGVQKNATS-------------------TKADAERTF---- 1449
Cdd:pfam15921  691 ETTTNKLKMQLKSAQSELEQTRNtlKSMEgsdghAMKVAMGMQKQITAkrgqidalqskiqfleeamTNANKEKHFlkee 770

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1450 -----SEVTDLDNEVNGMLRQLEEAENELKR-KQDDADQDMMMAGMASQAAQEAELNARKAKNSVSSLLSQLTDLLEQLG 1523
Cdd:pfam15921  771 knklsQELSTVATEKNKMAGELEVLRSQERRlKEKVANMEVALDKASLQFAECQDIIQRQEQESVRLKLQHTLDVKELQG 850

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 281371490  1524 QLDTVDLNKLNEIEGSLNKAKDEMKVSDLDRKVSNLENEARKQEAAILDYDRDIAEIIKDI 1584
Cdd:pfam15921  851 PGYTSNSSMKPRLLQPASFTRTHSNVPSSQSTASFLSHHSRKTNALKEDPTRDLKQLLQEL 911
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1027-1335 1.33e-10

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 65.94  E-value: 1.33e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1027 QECPACYRLVKDKVAEHRVKLQELESLIANLGTGdETVTDQAFEDRLKEAEREVTDLLREAQEvkdvdqnLMDRLQRVNN 1106
Cdd:COG4717   142 AELPERLEELEERLEELRELEEELEELEAELAEL-QEELEELLEQLSLATEEELQDLAEELEE-------LQQRLAELEE 213

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1107 SLHSQISRLHNIRNTIE--ETGILAERARSRVESTEQLIEIAS--------------RELEKAKMAAANVSITQPESTGE 1170
Cdd:COG4717   214 ELEEAQEELEELEEELEqlENELEAAALEERLKEARLLLLIAAallallglggsllsLILTIAGVLFLVLGLLALLFLLL 293

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1171 PNNMTLLAEEARRLAERHKQEA------DDIVRVAKTANETSAEAYNLLLRTLAGENQTALEIEELNRKYEQA---KNIS 1241
Cdd:COG4717   294 AREKASLGKEAEELQALPALEEleeeelEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQLEeleQEIA 373

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1242 QDLEK----------QAARVHEEAKRAGDKAVEIYASVAQLTPVDSEALES-EANKIKKEAADLDRLIDQKLKDYEDLRE 1310
Cdd:COG4717   374 ALLAEagvedeeelrAALEQAEEYQELKEELEELEEQLEELLGELEELLEAlDEEELEEELEELEEELEELEEELEELRE 453

                         330       340
                  ....*....|....*....|....*
gi 281371490 1311 DMRGKEHEVKNLLEKGKAEQQTADQ 1335
Cdd:COG4717   454 ELAELEAELEQLEEDGELAELLQEL 478
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
722-763 2.86e-10

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 56.94  E-value: 2.86e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 281371490    722 CTCNG---HSETCDPETGVCDCRDNTAGPHCEKCSDGYYGDSTLG 763
Cdd:smart00180    1 CDCDPggsASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPPG 45
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1072-1568 3.38e-10

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 65.06  E-value: 3.38e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1072 RLKEAEREVTDLLREAQEVKDvDQNLMDRLqrvnNSLHSQISRLHNIRNTIEETGILAERARSRVEST-----EQLIEIA 1146
Cdd:PRK02224  180 RVLSDQRGSLDQLKAQIEEKE-EKDLHERL----NGLESELAELDEEIERYEEQREQARETRDEADEVleeheERREELE 254

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1147 SRELEKAKMAAAnvsITQPESTGEPnnmtlLAEEARRLAERHKQEADDIVRVAKTANETSAEAYNLLLRTLAGENqtalE 1226
Cdd:PRK02224  255 TLEAEIEDLRET---IAETEREREE-----LAEEVRDLRERLEELEEERDDLLAEAGLDDADAEAVEARREELED----R 322

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1227 IEELNRKYEQAKNISQDLEKQAARVHEEAKRagdkaveiyasvaqltpvdseaLESEANKIKKEAADLDrlidqklKDYE 1306
Cdd:PRK02224  323 DEELRDRLEECRVAAQAHNEEAESLREDADD----------------------LEERAEELREEAAELE-------SELE 373

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1307 DLREDMRGKEHEVKNLlekgkaEQQTADQllaradaakalaeeaakkgRNTLQEANDILNNLKDFDRRVNDNKTAAEEAL 1386
Cdd:PRK02224  374 EAREAVEDRREEIEEL------EEEIEEL-------------------RERFGDAPVDLGNAEDFLEELREERDELRERE 428

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1387 RRIPAinrTIAEANEKTREAQ--LALGN--------------AAADATEAKNKAHEAERIASGVQKNATSTK----ADAE 1446
Cdd:PRK02224  429 AELEA---TLRTARERVEEAEalLEAGKcpecgqpvegsphvETIEEDRERVEELEAELEDLEEEVEEVEERleraEDLV 505

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1447 RTFSEVTDLDNEVNGMLRQLEEAENELKRKQD-------DADQDMMMAGMASQAAQEAELNARKAKNSVSSLLSQLTDLL 1519
Cdd:PRK02224  506 EAEDRIERLEERREDLEELIAERRETIEEKREraeelreRAAELEAEAEEKREAAAEAEEEAEEAREEVAELNSKLAELK 585

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 281371490 1520 EQLGQLDTV------------DLNKLNEIEGSLNKAKDEMK--VSDLDRKVSNLE---NEARKQEA 1568
Cdd:PRK02224  586 ERIESLERIrtllaaiadaedEIERLREKREALAELNDERRerLAEKRERKRELEaefDEARIEEA 651
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 980-1027 3.51e-10

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 56.59  E-value: 3.51e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 281371490  980 PCDCHHEGSLSLQC-KDDGRCECREGFVGNRCDQCEENYFYNRSWP-GCQ 1027
Cdd:cd00055     1 PCDCNGHGSLSGQCdPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGgGCQ 50
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
882-930 3.55e-10

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 56.55  E-value: 3.55e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 281371490    882 CACNPYGTVQqqSSCNPVTGQCQCLPHVSGRDCGACDPGFYNlQSGQGC 930
Cdd:smart00180    1 CDCDPGGSAS--GTCDPDTGQCECKPNVTGRRCDRCAPGYYG-DGPPGC 46
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 1044-1580 7.30e-10

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 64.22  E-value: 7.30e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1044 RVKLQ---ELESLIANLGTGDETVTDQAFEDRLKEAEREVTDL---------LREAQEVKDVDQNLMDRLQRVNNSLHSQ 1111
Cdd:TIGR00618  196 AELLTlrsQLLTLCTPCMPDTYHERKQVLEKELKHLREALQQTqqshayltqKREAQEEQLKKQQLLKQLRARIEELRAQ 275

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1112 ISRLHNIRNTIEetgilaeraRSRvesteqlieiasrelEKAKMAAANVSITQPESTGEPNNMTLLAEEARRLAERHKqe 1191
Cdd:TIGR00618  276 EAVLEETQERIN---------RAR---------------KAAPLAAHIKAVTQIEQQAQRIHTELQSKMRSRAKLLMK-- 329

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1192 addivRVAKTANETSAEAYNLLLRTLAGENqtaleiEELNRKYEQAKNISQDLEKQAARVHEEAKRAGDKaveiyasvaq 1271
Cdd:TIGR00618  330 -----RAAHVKQQSSIEEQRRLLQTLHSQE------IHIRDAHEVATSIREISCQQHTLTQHIHTLQQQK---------- 388

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1272 ltpvdsEALESEANKIKKEAADLDRL---IDQKLKDYEDLREDMRGKEHEVKnlLEKGKAEQQtaDQLLARADAAKALAE 1348
Cdd:TIGR00618  389 ------TTLTQKLQSLCKELDILQREqatIDTRTSAFRDLQGQLAHAKKQQE--LQQRYAELC--AAAITCTAQCEKLEK 458

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1349 EAAKKGRNTLQEANDILNNLKDFDRRVNDNKTAAEEALRRIPAINRTIAEANEKTREAQLALGNAAAD-----ATEAKNK 1423
Cdd:TIGR00618  459 IHLQESAQSLKEREQQLQTKEQIHLQETRKKAVVLARLLELQEEPCPLCGSCIHPNPARQDIDNPGPLtrrmqRGEQTYA 538

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1424 AHE-----AERIASGVQKNATSTKADAER---TFSEVTDLDNEV----NGMLRQLE------EAENELKRKQDDADQDMM 1485
Cdd:TIGR00618  539 QLEtseedVYHQLTSERKQRASLKEQMQEiqqSFSILTQCDNRSkediPNLQNITVrlqdltEKLSEAEDMLACEQHALL 618

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1486 MAGMASQAAQEAELNARKAKNSVSSLLSQLTDLLEQLGQLD--------TVD-LNKLNEIEGSLNKAKDEMKVSDLDRKV 1556
Cdd:TIGR00618  619 RKLQPEQDLQDVRLHLQQCSQELALKLTALHALQLTLTQERvrehalsiRVLpKELLASRQLALQKMQSEKEQLTYWKEM 698

                          570       580
                   ....*....|....*....|....*
gi 281371490  1557 SNLENEA-RKQEAAILDYDRDIAEI 1580
Cdd:TIGR00618  699 LAQCQTLlRELETHIEEYDREFNEI 723
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
981-1026 9.92e-10

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 55.40  E-value: 9.92e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 281371490    981 CDCHHEGSLSLQC-KDDGRCECREGFVGNRCDQCEENYfYNRSWPGC 1026
Cdd:smart00180    1 CDCDPGGSASGTCdPDTGQCECKPNVTGRRCDRCAPGY-YGDGPPGC 46
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 1042-1594 1.32e-09

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 63.27  E-value: 1.32e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1042 EHRVKL----QELESLIANLgtgdetvtdqafEDRLKEAEREVTDLLRE----AQEVKDVDQNLMD------RLQRVNNS 1107
Cdd:pfam01576   61 EMRARLaarkQELEEILHEL------------ESRLEEEEERSQQLQNEkkkmQQHIQDLEEQLDEeeaarqKLQLEKVT 128

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1108 LHSQISRLhnirntiEETGILAERARSRVESTEQLIEIASRELEkakmaaanvsitqpestgepNNMTLLAEEARRLAE- 1186
Cdd:pfam01576  129 TEAKIKKL-------EEDILLLEDQNSKLSKERKLLEERISEFT--------------------SNLAEEEEKAKSLSKl 181

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1187 RHKQEA---DDIVRVAKtaNETSAEAYNLLLRTLAGE-----NQTA---LEIEELnrkyeQAKNISQDLEKQAA--RVHE 1253
Cdd:pfam01576  182 KNKHEAmisDLEERLKK--EEKGRQELEKAKRKLEGEstdlqEQIAelqAQIAEL-----RAQLAKKEEELQAAlaRLEE 254

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1254 E--AKRAGDKAV-EIYASVAQLtpvdSEALESEA---NKIKKEAADLDRLIDQKLKDYED------LREDMRGK-EHEV- 1319
Cdd:pfam01576  255 EtaQKNNALKKIrELEAQISEL----QEDLESERaarNKAEKQRRDLGEELEALKTELEDtldttaAQQELRSKrEQEVt 330

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1320 ---KNLLEKGKA-EQQTAD--QLLARADAAKALAEEAAKKGRNTLQEANDIL----NNLKDFDRRVNDNKTAAEEALRRI 1389
Cdd:pfam01576  331 elkKALEEETRShEAQLQEmrQKHTQALEELTEQLEQAKRNKANLEKAKQALesenAELQAELRTLQQAKQDSEHKRKKL 410

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1390 PA-----------INRTIAEANEKTREAQLALGNAAADATEAKNKAHEAERIASGVQknatSTKADAERTFSEVT----- 1453
Cdd:pfam01576  411 EGqlqelqarlseSERQRAELAEKLSKLQSELESVSSLLNEAEGKNIKLSKDVSSLE----SQLQDTQELLQEETrqkln 486

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1454 ------DLDNEVNGMLRQLEEAE-----------------NELKRKQDDadqdmmMAGmASQAAQEAElnaRKAKNSVSS 1510
Cdd:pfam01576  487 lstrlrQLEDERNSLQEQLEEEEeakrnverqlstlqaqlSDMKKKLEE------DAG-TLEALEEGK---KRLQRELEA 556

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1511 LLSQLT------DLLEQL-----GQLD--TVDLNKLNEIEGSLNKAK--------DEMKVS-----DLDRKvsnlENEAR 1564
Cdd:pfam01576  557 LTQQLEekaaayDKLEKTknrlqQELDdlLVDLDHQRQLVSNLEKKQkkfdqmlaEEKAISaryaeERDRA----EAEAR 632

                          650       660       670
                   ....*....|....*....|....*....|
gi 281371490  1565 KQEAAILDYDRDIAEIIKDIHNLEDIKKTL 1594
Cdd:pfam01576  633 EKETRALSLARALEEALEAKEELERTNKQL 662
CHASE3 COG5278
Extracytoplasmic sensor domain CHASE3 (specificity unknown) [Signal transduction mechanisms];
1033-1483 2.13e-09

Extracytoplasmic sensor domain CHASE3 (specificity unknown) [Signal transduction mechanisms];


Pssm-ID: 444089 [Multi-domain]  Cd Length: 530  Bit Score: 61.85  E-value: 2.13e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1033 YRLVKDKVAEHrvkLQELESLIANLGTGDETVTD--QAFEDRLKEAEREVtDLLRE-------AQEVKDVDQNLMDRlqr 1103
Cdd:COG5278    81 YEEARAEIDEL---LAELRSLTADNPEQQARLDEleALIDQWLAELEQVI-ALRRAggleaalALVRSGEGKALMDE--- 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1104 vnnslhsqisrlhnIRNTIEETGILAERARSRVESTEQLIEIASRELEKAKMAAANVSITQPESTGEPNNMTLLAEEARR 1183
Cdd:COG5278   154 --------------IRARLLLLALALAALLLAAAALLLLLLALAALLALAELLLLALARALAALLLLLLLEAELAAAAAL 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1184 LAERHKQEADDIVRVAKTANETSAEAYNLLLRTLAGENQTALEIEELNRKYEQAKNISQDLEKQAARVHEEAKRAGDKAV 1263
Cdd:COG5278   220 LAAAAALAALAALELLAALALALALLLAALLLALLAALALAALLAAALLALAALLLALAAAAALAAAAALELAAAEALAL 299

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1264 EIYASVAQLTPVDSEALESEANKIKKEAADLDRLIDQKLKDYEDLREDMRGKEHEVKNLLEKGKAEQQTADQLLARADAA 1343
Cdd:COG5278   300 AELELELLLAAAAAAAAAAAAAAAALAALLALALATALAAAAAALALLAALLAEAAAAAAEEAEAAAEAAAAALAGLAEV 379

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1344 KALAEEAAKKGRNTLQEANDILNNLKDFDRRVNDNKTAAEEALRRIPAINRTIAEANEKTREAQLALGNAAADATEAKNK 1423
Cdd:COG5278   380 EAEGAAEAVELEVLAIAAAAAAAAAEAAAAAAAAAAASAAEALELAEALAEALALAEEEALALAAASSELAEAGAALALA 459

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1424 AHEAERIASGVQKNATSTKADAERTFSEVTDLDNEVNGMLRQLEEAENELKRKQDDADQD 1483
Cdd:COG5278   460 AAEALAEELAAVAALAALAAAAAALAEAEAAAALAAAAALSLALALAALLLAAAEAALAA 519
growth_prot_Scy NF041483
polarized growth protein Scy;
1129-1504 3.32e-09

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 62.15  E-value: 3.32e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1129 AERARSRVES--------TEQLIEIASRELEKAKMAAANVSITqpeSTGEPNNMTLLAEEARRLAERHKQEADDIVRVAK 1200
Cdd:NF041483  202 AESARAEAEAilrrarkdAERLLNAASTQAQEATDHAEQLRSS---TAAESDQARRQAAELSRAAEQRMQEAEEALREAR 278

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1201 T-ANETSAEAYNLLLRTLAG-----ENQTALEIEELNRKYEQAKNISQDLEKQAARVHEEAK--------RAGDKAVEIY 1266
Cdd:NF041483  279 AeAEKVVAEAKEAAAKQLASaesanEQRTRTAKEEIARLVGEATKEAEALKAEAEQALADARaeaeklvaEAAEKARTVA 358

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1267 A--SVAQLTPVDSEALE-----------------SEANKIKKEA-ADLDRLIDQKlkdyEDLREDMRG------KEHEVK 1320
Cdd:NF041483  359 AedTAAQLAKAARTAEEvltkasedakattraaaEEAERIRREAeAEADRLRGEA----ADQAEQLKGaakddtKEYRAK 434

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1321 N--LLE-----KGKAEQQTADQLLARADAAKALAEEAAKKGRNTLQEANDILNNLK-DFDRRVNDNKTAAE----EALRR 1388
Cdd:NF041483  435 TveLQEearrlRGEAEQLRAEAVAEGERIRGEARREAVQQIEEAARTAEELLTKAKaDADELRSTATAESErvrtEAIER 514

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1389 IPAINRTIAEANEKTREaqlalgnaaadateaknkahEAERIASGVQKNATSTKADAERTFSEVTDlDNEVNGMLRQLEE 1468
Cdd:NF041483  515 ATTLRRQAEETLERTRA--------------------EAERLRAEAEEQAEEVRAAAERAARELRE-ETERAIAARQAEA 573

                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 281371490 1469 AEnELKRKQDDADQDMMMAGMA-SQAAQEAELNARKA 1504
Cdd:NF041483  574 AE-ELTRLHTEAEERLTAAEEAlADARAEAERIRREA 609
MA smart00283
Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo ...
 1089-1300 4.77e-09

Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.


Pssm-ID: 214599 [Multi-domain]  Cd Length: 262  Bit Score: 59.22  E-value: 4.77e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490   1089 EVKDVDQNLMDRLQRVNNSLHSQISRLHNIRNTIEETGILAERARSRVESTEQLIEIASRELEKAKMAAANVSITQPEST 1168
Cdd:smart00283    1 DVSEAVEEIAAGAEEQAEELEELAERMEELSASIEEVAANADEIAATAQSAAEAAEEGREAVEDAITAMDQIREVVEEAV 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490   1169 G-----------------------EPNNMTLL-------------------AEEARRLAERHKQEADDIVRVAKTANETS 1206
Cdd:smart00283   81 SaveeleessdeigeivsviddiaDQTNLLALnaaieaarageagrgfavvADEVRKLAERSAESAKEIESLIKEIQEET 160

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490   1207 AEAYNLLLRTLAGENQTALEIEELNRKYE----QAKNISQDLEKQAARVHEEAKRAGD--KAVEIYASVAQLTPVDSEAL 1280
Cdd:smart00283  161 NEAVAAMEESSSEVEEGVELVEETGDALEeivdSVEEIADLVQEIAAATDEQAAGSEEvnAAIDEIAQVTQETAAMSEEI 240

                           250       260
                    ....*....|....*....|
gi 281371490   1281 ESEANKIKKEAADLDRLIDQ 1300
Cdd:smart00283  241 SAAAEELSGLAEELDELVER 260
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1037-1479 4.84e-09

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 61.21  E-value: 4.84e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1037 KDKVAEHRVKLQELESLIANLGTGDETVTD-----QAFEDRLKEAEREVTDL------LREAQEVKDVDQN-LMDRLQRV 1104
Cdd:PRK02224  240 DEVLEEHEERREELETLEAEIEDLRETIAEtererEELAEEVRDLRERLEELeeerddLLAEAGLDDADAEaVEARREEL 319

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1105 NNSLHSQISRLHNIRNTIEETGILAERARsrvESTEQLIEIASRELEKAKMAAANVSITQPESTGEPNNMTLLAEEARRL 1184
Cdd:PRK02224  320 EDRDEELRDRLEECRVAAQAHNEEAESLR---EDADDLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIEEL 396

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1185 AERHKQEADDIVRvaktanetsAEAYNLLLRtlagenqtaleiEELNRKYEQAKNISQDLEKQAARVHE-EAKRAGDKAV 1263
Cdd:PRK02224  397 RERFGDAPVDLGN---------AEDFLEELR------------EERDELREREAELEATLRTARERVEEaEALLEAGKCP 455

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1264 EIYASVAQLTPVDS--------EALESEANKIKKEAADLDRLIDQ--KLKDYEDLREDMRGKEHEVKNLLEKGKA----E 1329
Cdd:PRK02224  456 ECGQPVEGSPHVETieedrervEELEAELEDLEEEVEEVEERLERaeDLVEAEDRIERLEERREDLEELIAERREtieeK 535

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1330 QQTADQLLARADAAKALAEEAAKKGRNTLQEANDILNNLKDFDRRVNDNKTAAeEALRRIPAINRTIAEA-------NEK 1402
Cdd:PRK02224  536 RERAEELRERAAELEAEAEEKREAAAEAEEEAEEAREEVAELNSKLAELKERI-ESLERIRTLLAAIADAedeierlREK 614

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1403 tREAQLALGNAAADATEAKNK-------AHEAERIASGVQK--NATSTKADAERTFSEVT----DLDNEVNGMLRQLEEA 1469
Cdd:PRK02224  615 -REALAELNDERRERLAEKRErkreleaEFDEARIEEAREDkeRAEEYLEQVEEKLDELReerdDLQAEIGAVENELEEL 693

                         490
                  ....*....|
gi 281371490 1470 EnELKRKQDD 1479
Cdd:PRK02224  694 E-ELRERREA 702
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
1089-1335 5.53e-09

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 59.54  E-value: 5.53e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1089 EVKDVDQNLMDRLQRVNNSLHSQISRLHNIRNT-IEETGILAERARSRVESTEQLIEIASRELEKAKMAAANVSitqpES 1167
Cdd:COG1340     1 SKTDELSSSLEELEEKIEELREEIEELKEKRDElNEELKELAEKRDELNAQVKELREEAQELREKRDELNEKVK----EL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1168 TGEPNNmtlLAEEARRL---AERHKQEADDIVRVAKTANETSaEAYNLLLR-------TLAGENQTALEIEELNRKYEQA 1237
Cdd:COG1340    77 KEERDE---LNEKLNELreeLDELRKELAELNKAGGSIDKLR-KEIERLEWrqqtevlSPEEEKELVEKIKELEKELEKA 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1238 KNI-------------SQDLEKQAARVHEEAKRAGDKAVEIYASVAQLTP-VDS-----EALESEANKIKKEAADLDRLI 1298
Cdd:COG1340   153 KKAlekneklkelraeLKELRKEAEEIHKKIKELAEEAQELHEEMIELYKeADElrkeaDELHKEIVEAQEKADELHEEI 232

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 281371490 1299 DQKLKDYEDLREdmrgkehEVKNLLEKGKAEQQTADQ 1335
Cdd:COG1340   233 IELQKELRELRK-------ELKKLRKKQRALKREKEK 262
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 1172-1589 5.66e-09

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 61.29  E-value: 5.66e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1172 NNMTLLAEEAR----RLAERHKQEADDIVRVAKTAnetsaeaynlllRTLAGENQTALEIEElnrkyEQAKNIS------ 1241
Cdd:pfam15921  256 NKIELLLQQHQdrieQLISEHEVEITGLTEKASSA------------RSQANSIQSQLEIIQ-----EQARNQNsmymrq 318

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1242 -QDLEKQAARVH---EEAKRAGDKAVEIYASvaQLTPVDSEALE--SEANKIKKEAADLDRLIDQKLKDYEDLREDMRGK 1315
Cdd:pfam15921  319 lSDLESTVSQLRselREAKRMYEDKIEELEK--QLVLANSELTEarTERDQFSQESGNLDDQLQKLLADLHKREKELSLE 396

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1316 EHEVKNLLEKGKAEQQTADQLLARADAakalaeeaakkgRNT-LQEANDILNNLKDFDRRVNDNKTAA----EEALRRIP 1390
Cdd:pfam15921  397 KEQNKRLWDRDTGNSITIDHLRRELDD------------RNMeVQRLEALLKAMKSECQGQMERQMAAiqgkNESLEKVS 464

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1391 AINRTIaeanEKTREAqlaLGNAAADATEAKNKAHEAERIASGVQKNATSTKADAERTFSEVTDLDNEVNGMLRQLEEAE 1470
Cdd:pfam15921  465 SLTAQL----ESTKEM---LRKVVEELTAKKMTLESSERTVSDLTASLQEKERAIEATNAEITKLRSRVDLKLQELQHLK 537

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1471 NE---LKRKQDDADQ-DMMMAGmasqaaqeaelnarkaKNSVSSLLSQ----LTDLLEQLGQLDTVDLNKLNEIEGSLN- 1541
Cdd:pfam15921  538 NEgdhLRNVQTECEAlKLQMAE----------------KDKVIEILRQqienMTQLVGQHGRTAGAMQVEKAQLEKEINd 601

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 281371490  1542 -----------KAKDEMKVSDLDRKVSNLENEARKqeaaILDYDRDIAEIIKDIHNLED 1589
Cdd:pfam15921  602 rrlelqefkilKDKKDAKIRELEARVSDLELEKVK----LVNAGSERLRAVKDIKQERD 656
growth_prot_Scy NF041483
polarized growth protein Scy;
1065-1504 6.41e-09

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 61.00  E-value: 6.41e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1065 TDQAFEDRLKEAEREVTDLLREAQEvkdvdqnlmdRLQRVNNSL---HSQISRLHniRNTIEETGIL----AERARSRVE 1137
Cdd:NF041483  562 TERAIAARQAEAAEELTRLHTEAEE----------RLTAAEEALadaRAEAERIR--REAAEETERLrteaAERIRTLQA 629

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1138 STEQLIEIASRElekakmAAANVSITQPEstGEpNNMTLLAEEARRLAERHK---QEADDIVRV-AKTANE----TSAEA 1209
Cdd:NF041483  630 QAEQEAERLRTE------AAADASAARAE--GE-NVAVRLRSEAAAEAERLKseaQESADRVRAeAAAAAErvgtEAAEA 700

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1210 YNLLLRTLAGENQTALEI-----EELNRKYEQAKNISQDL-----------EKQAARVHEEA-KRAGD-------KAVEI 1265
Cdd:NF041483  701 LAAAQEEAARRRREAEETlgsarAEADQERERAREQSEELlasarkrveeaQAEAQRLVEEAdRRATElvsaaeqTAQQV 780

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1266 YASVAQLTPVDSE-------ALESEANKIKKEAAD-LDRL-------IDQKLKDYEDLREDMRGKEHEVKNLLEKGKAE- 1329
Cdd:NF041483  781 RDSVAGLQEQAEEeiaglrsAAEHAAERTRTEAQEeADRVrsdayaeRERASEDANRLRREAQEETEAAKALAERTVSEa 860

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1330 --------QQTADQLLARADAAKALAEEAAKKGRNTLQEANDILNNLKD-----FDRRVNDNKTAAEealrRIPAINRTI 1396
Cdd:NF041483  861 iaeaerlrSDASEYAQRVRTEASDTLASAEQDAARTRADAREDANRIRSdaaaqADRLIGEATSEAE----RLTAEARAE 936

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1397 AE--ANEKTREAQLALGNAAADATEAKNKAH-EAERIASGVQKNATSTKADAERTFSE----VTDLDNEVNGML------ 1463
Cdd:NF041483  937 AErlRDEARAEAERVRADAAAQAEQLIAEATgEAERLRAEAAETVGSAQQHAERIRTEaervKAEAAAEAERLRtearee 1016

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*...
gi 281371490 1464 --RQLEEAENEL-KRKQDDADQ-DMMMAGMASQAAQ---EAELNARKA 1504
Cdd:NF041483 1017 adRTLDEARKDAnKRRSEAAEQaDTLITEAAAEADQltaKAQEEALRT 1064
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 826-873 8.67e-09

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 52.74  E-value: 8.67e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 281371490   826 CQCNDNIDPNavGNCNRLTGECLkCIYNTAGFYCDRCKEGFFGNPLAP 873
Cdd:pfam00053    1 CDCNPHGSLS--DTCDPETGQCL-CKPGVTGRHCDRCKPGYYGLPSDP 45
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 1032-1524 9.09e-09

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 60.57  E-value: 9.09e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1032 CYRLVKDkVAEHRVKLQELESLIAnlgtgDETVTDQAFEDRLKEAEREVTDLLREAQEVKDVDQNLMDRLQRVNNSLHSQ 1111
Cdd:pfam01576  456 NIKLSKD-VSSLESQLQDTQELLQ-----EETRQKLNLSTRLRQLEDERNSLQEQLEEEEEAKRNVERQLSTLQAQLSDM 529

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1112 ISRLHNIRNTIEetgiLAERARSRVESTeqlIEIASRELEKAKMAAANVSITQPESTGEPNNMT---------------- 1175
Cdd:pfam01576  530 KKKLEEDAGTLE----ALEEGKKRLQRE---LEALTQQLEEKAAAYDKLEKTKNRLQQELDDLLvdldhqrqlvsnlekk 602

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1176 ------LLAEE----ARRLAERHKQEADdivrvaktANETSAEAYnlllrTLAGENQTALE-IEELNRKYEQAKNISQDL 1244
Cdd:pfam01576  603 qkkfdqMLAEEkaisARYAEERDRAEAE--------AREKETRAL-----SLARALEEALEaKEELERTNKQLRAEMEDL 669

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1245 --EKQAA--RVH--EEAKRAGDKAVEiyASVAQLTPVDSEALESEANKIKKEA------ADLDRLIDQKLKDYEDLREDM 1312
Cdd:pfam01576  670 vsSKDDVgkNVHelERSKRALEQQVE--EMKTQLEELEDELQATEDAKLRLEVnmqalkAQFERDLQARDEQGEEKRRQL 747

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1313 RGKEHEVKNLLE---KGKAEQQTADQLLARADAAKALAEEAAKKGRN-TLQEANDILNNLKDFDRRVNDNKTAAEEALrr 1388
Cdd:pfam01576  748 VKQVRELEAELEderKQRAQAVAAKKKLELDLKELEAQIDAANKGREeAVKQLKKLQAQMKDLQRELEEARASRDEIL-- 825

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1389 ipainrTIAEANE---KTREAQ-LALGNAAADATEAKNKAhEAER------IASGVQKNAtSTKADAERTFSEVTDLDNE 1458
Cdd:pfam01576  826 ------AQSKESEkklKNLEAElLQLQEDLAASERARRQA-QQERdeladeIASGASGKS-ALQDEKRRLEARIAQLEEE 897

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1459 ----------VNGMLR----QLEEAENELK------RKQDDADQDMmmagmasqAAQEAELNAR----------KAKNSV 1508
Cdd:pfam01576  898 leeeqsntelLNDRLRkstlQVEQLTTELAaerstsQKSESARQQL--------ERQNKELKAKlqemegtvksKFKSSI 969

                          570
                   ....*....|....*.
gi 281371490  1509 SSLLSQLTDLLEQLGQ 1524
Cdd:pfam01576  970 AALEAKIAQLEEQLEQ 985
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1208-1565 9.14e-09

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 60.46  E-value: 9.14e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1208 EAYNLLLRTLagENQTALE--IEELNRKYEQaknisqdLEKQAARVHE-EAKRAGDKAVEIYASVAQLTPVDSE--ALES 1282
Cdd:TIGR02168  176 ETERKLERTR--ENLDRLEdiLNELERQLKS-------LERQAEKAERyKELKAELRELELALLVLRLEELREEleELQE 246

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1283 EANKIKKEAADLDRLIDQKLKDYEDLR----EDMRGKEHEVKNLLEKgKAEQQTADQllaradaakalaeeaakkgrnTL 1358
Cdd:TIGR02168  247 ELKEAEEELEELTAELQELEEKLEELRlevsELEEEIEELQKELYAL-ANEISRLEQ---------------------QK 304

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1359 QEANDILNNLKDFDRRVNdnkTAAEEALRRIPAINRTIAEANEKTREAQLALGNAAADATEAKNKAHEAERIASGVQKNA 1438
Cdd:TIGR02168  305 QILRERLANLERQLEELE---AQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQL 381

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1439 TSTKADAERTFSEVTDLDNEVNGMLRQLEEAENELKRKQD---DADQDMMMAGMASQAAQEAELN-----ARKAKNSVSS 1510
Cdd:TIGR02168  382 ETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQeieELLKKLEEAELKELQAELEELEeeleeLQEELERLEE 461

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 281371490  1511 LLSQLTDLLEQLGQLDTVDLNKLNEIEGSLNKAKDEM-KVSDLDRKVSNLENEARK 1565
Cdd:TIGR02168  462 ALEELREELEEAEQALDAAERELAQLQARLDSLERLQeNLEGFSEGVKALLKNQSG 517
PRK01156 PRK01156
chromosome segregation protein; Provisional
 1076-1587 1.62e-08

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 59.53  E-value: 1.62e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1076 AEREvtDLLREAQEVKDVDQNlMDRLQRVNNSLHSQISRLHNIRNTIEETGILAERARSRVESTEQLIEIASRELEKAKM 1155
Cdd:PRK01156  149 AQRK--KILDEILEINSLERN-YDKLKDVIDMLRAEISNIDYLEEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSI 225

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1156 AAANVSITQPESTGEPNNMTLLAEEARRLAERHKQEADDIVRVAKTANETSA--EAYNLLLRTLAGENQTAL-----EIE 1228
Cdd:PRK01156  226 EYNNAMDDYNNLKSALNELSSLEDMKNRYESEIKTAESDLSMELEKNNYYKEleERHMKIINDPVYKNRNYIndyfkYKN 305

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1229 ELNRKYEQAKNISQDLEKqaarvHEEAKRagdKAVEIyasvaqltpvdsEALESEANKIKKEAADLDRLIDQkLKDYEDl 1308
Cdd:PRK01156  306 DIENKKQILSNIDAEINK-----YHAIIK---KLSVL------------QKDYNDYIKKKSRYDDLNNQILE-LEGYEM- 363

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1309 reDMRGKEHEVKNLleKGKAEQQTADQLLARADAAKALAeeaakkgrntLQEAN-DILNN-LKDFDRRVNDNKTAAEEAL 1386
Cdd:PRK01156  364 --DYNSYLKSIESL--KKKIEEYSKNIERMSAFISEILK----------IQEIDpDAIKKeLNEINVKLQDISSKVSSLN 429

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1387 RRIPAInrtIAEANEKTREAQLALGNAAADATEAKNKAHEAERIASGVQKNATSTKADAERTFSEVTDLDNEV------- 1459
Cdd:PRK01156  430 QRIRAL---RENLDELSRNMEMLNGQSVCPVCGTTLGEEKSNHIINHYNEKKSRLEEKIREIEIEVKDIDEKIvdlkkrk 506

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1460 ----NGMLRQLEEAENELKRKQDDADQDMmmagMASQAAQEAELNARKAKNSVSS-----LLSQLTDLLEQLGQLDTVDL 1530
Cdd:PRK01156  507 eyleSEEINKSINEYNKIESARADLEDIK----IKINELKDKHDKYEEIKNRYKSlkledLDSKRTSWLNALAVISLIDI 582

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 281371490 1531 NKL----NEIEGSLNKAKDEMKV---------SDLDRKVSNLENEA---RKQEAAILDYDRDIAEIIKDIHNL 1587
Cdd:PRK01156  583 ETNrsrsNEIKKQLNDLESRLQEieigfpddkSYIDKSIREIENEAnnlNNKYNEIQENKILIEKLRGKIDNY 655
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1028-1454 1.63e-08

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 59.69  E-value: 1.63e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1028 ECPACYRLVKDkvaEHRVKLqeleslianlgtgdetvtdqafedrLKEAEREVTDLLREAQEVKDVDQNLMDRLQRVNNS 1107
Cdd:PRK03918  437 KCPVCGRELTE---EHRKEL-------------------------LEEYTAELKRIEKELKEIEEKERKLRKELRELEKV 488

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1108 L--HSQISRLHNIRNTIEETgilaeraRSRVES--TEQLiEIASRELEKAKMAAANVSitqpestGEPNNmtlLAEEARR 1183
Cdd:PRK03918  489 LkkESELIKLKELAEQLKEL-------EEKLKKynLEEL-EKKAEEYEKLKEKLIKLK-------GEIKS---LKKELEK 550

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1184 LAErHKQEADDIVRVAKTANETSAEAYNLLLR----TLAGENQTALEIEELNRKYEQAKNISQDLEkqaaRVHEEAKRAG 1259
Cdd:PRK03918  551 LEE-LKKKLAELEKKLDELEEELAELLKELEElgfeSVEELEERLKELEPFYNEYLELKDAEKELE----REEKELKKLE 625

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1260 DKAVEIYASVAQLtpvdsealESEANKIKKEAADLDRLIDQKlkDYEDLREDMRGKEHEVKNLLEKGKAEqqtadqllar 1339
Cdd:PRK03918  626 EELDKAFEELAET--------EKRLEELRKELEELEKKYSEE--EYEELREEYLELSRELAGLRAELEEL---------- 685

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1340 adaakalaeeaakkgRNTLQEANDILNNLKdfdrrvnDNKTAAEEALRRIPAINRTIAEAnEKTREAQLALGNaaadatE 1419
Cdd:PRK03918  686 ---------------EKRREEIKKTLEKLK-------EELEEREKAKKELEKLEKALERV-EELREKVKKYKA------L 736

                         410       420       430
                  ....*....|....*....|....*....|....*.
gi 281371490 1420 AKNKA-HEAERIASGVqknatstkadaertFSEVTD 1454
Cdd:PRK03918  737 LKERAlSKVGEIASEI--------------FEELTE 758
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 981-1027 1.77e-08

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 51.97  E-value: 1.77e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 281371490   981 CDCHHEGSLSLQC-KDDGRCECREGFVGNRCDQCEENYFYNRSWPGCQ 1027
Cdd:pfam00053    1 CDCNPHGSLSDTCdPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQG 48
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1039-1428 2.06e-08

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 58.38  E-value: 2.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1039 KVAEHRVKLQELE----SLIANLgtgDETVTDQAFEdrLKEAEREVTDLLREAQEVKdvdqnlmDRLQRVNNSLHSQISR 1114
Cdd:COG4372     7 KVGKARLSLFGLRpktgILIAAL---SEQLRKALFE--LDKLQEELEQLREELEQAR-------EELEQLEEELEQARSE 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1115 LHNIRNTIEETGILAERARSRVESTEQLIEIASRELEKAKMAAANvsitqpestgepnnmtlLAEEARRLAERHKQEADD 1194
Cdd:COG4372    75 LEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEE-----------------LQKERQDLEQQRKQLEAQ 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1195 IVRVAKTANETSAEaynllLRTLAGE-NQTALEIEELNRKYEQAKNisQDLEKQAARVHEEAKRAGDKAVEIY-ASVAQL 1272
Cdd:COG4372   138 IAELQSEIAEREEE-----LKELEEQlESLQEELAALEQELQALSE--AEAEQALDELLKEANRNAEKEEELAeAEKLIE 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1273 TPVDSEALESEANKIKKEAADLDRLIDQKLKDYEDLREDMRGKEHEVKNLLEKGKAEQQTADQLLARADAAKALAEEAAK 1352
Cdd:COG4372   211 SLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVILKEIEELELAILVEKDTEEEELEIAALELEALEE 290

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 281371490 1353 KGRNTLQEANDILNNLKDFDRRVNDNKTAAEEALRRIPAINRTIAEANEKTREAQLALGNAAADATEAKNKAHEAE 1428
Cdd:COG4372   291 AALELKLLALLLNLAALSLIGALEDALLAALLELAKKLELALAILLAELADLLQLLLVGLLDNDVLELLSKGAEAG 366
growth_prot_Scy NF041483
polarized growth protein Scy;
1070-1503 3.22e-08

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 58.68  E-value: 3.22e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1070 EDRLKEAEREVTDLLREAQE--VKDVDQNLMDRLQRVNNSlHSQISRLHNiRNTIEETGILAE----RARSRVEStEQLI 1143
Cdd:NF041483  271 EEALREARAEAEKVVAEAKEaaAKQLASAESANEQRTRTA-KEEIARLVG-EATKEAEALKAEaeqaLADARAEA-EKLV 347

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1144 EIASrelEKAKMAAANVSITQ---PESTGEpNNMTLLAEEARRLAERHKQEADDIVRVAKT-ANETSAEAYNLL--LRTL 1217
Cdd:NF041483  348 AEAA---EKARTVAAEDTAAQlakAARTAE-EVLTKASEDAKATTRAAAEEAERIRREAEAeADRLRGEAADQAeqLKGA 423

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1218 AGEN------QTALEIEELNRKYEQAKNISQDLEKQAARVHEEAKRAGDKAVEIYASVAQ--LTPVDSEALE------SE 1283
Cdd:NF041483  424 AKDDtkeyraKTVELQEEARRLRGEAEQLRAEAVAEGERIRGEARREAVQQIEEAARTAEelLTKAKADADElrstatAE 503

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1284 ANKIKKEAadLDRLIDQKlKDYEDLREDMRGKEHEVKNllekgKAEQQTADQLLARADAAKALAEEAAKKGRNTLQEAND 1363
Cdd:NF041483  504 SERVRTEA--IERATTLR-RQAEETLERTRAEAERLRA-----EAEEQAEEVRAAAERAARELREETERAIAARQAEAAE 575

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1364 ILNNLK-DFDRRVndnkTAAEEAL----------RRIPA--INRTIAEANEKTR--------EAQLALGNAAADATEAKN 1422
Cdd:NF041483  576 ELTRLHtEAEERL----TAAEEALadaraeaeriRREAAeeTERLRTEAAERIRtlqaqaeqEAERLRTEAAADASAARA 651

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1423 K------------AHEAERIASGVQKNATSTKAD----AERTFSEVTD-LDNEVNGMLRQLEEAENELKRKQDDADQDMm 1485
Cdd:NF041483  652 EgenvavrlrseaAAEAERLKSEAQESADRVRAEaaaaAERVGTEAAEaLAAAQEEAARRRREAEETLGSARAEADQER- 730

                         490
                  ....*....|....*...
gi 281371490 1486 maGMASQAAQEAELNARK 1503
Cdd:NF041483  731 --ERAREQSEELLASARK 746
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 1047-1605 4.86e-08

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 58.52  E-value: 4.86e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1047 LQELESLIANLgtgdETVTDQA-FEDRLKEAEREVTDLLREAQEVKDVDQNLmdrlqrvnNSLHSQISRLHNIRNTIEET 1125
Cdd:TIGR01612 1145 IDEIKAQINDL----EDVADKAiSNDDPEEIEKKIENIVTKIDKKKNIYDEI--------KKLLNEIAEIEKDKTSLEEV 1212

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1126 G-----------------ILAERARSR--VESTEQLIE------IASRELE---------KAKMAAANVSITQPE----- 1166
Cdd:TIGR01612 1213 KginlsygknlgklflekIDEEKKKSEhmIKAMEAYIEdldeikEKSPEIEnemgiemdiKAEMETFNISHDDDKdhhii 1292

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1167 STGEPNNMTLLAEEARRLAERHKQEAD--DIVRVAKTaNETSAEAYNLLLRTLAGENQTALEIEELNRkyeqAKNISQDL 1244
Cdd:TIGR01612 1293 SKKHDENISDIREKSLKIIEDFSEESDinDIKKELQK-NLLDAQKHNSDINLYLNEIANIYNILKLNK----IKKIIDEV 1367

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1245 EKQAARVHEEAKRAGDkavEIYASVAQLTPV-DSEALESEANKIKKEAADLDrlIDQKLKDYEDLREDMRGKEHEVKNLL 1323
Cdd:TIGR01612 1368 KEYTKEIEENNKNIKD---ELDKSEKLIKKIkDDINLEECKSKIESTLDDKD--IDECIKKIKELKNHILSEESNIDTYF 1442

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1324 EKGKAEQQTADQLLARADAAKALAEEAAKKGRNTLQEANDI-LNNLKDFDRRVNDNKTAAEEAlrripainrtiAEANEK 1402
Cdd:TIGR01612 1443 KNADENNENVLLLFKNIEMADNKSQHILKIKKDNATNDHDFnINELKEHIDKSKGCKDEADKN-----------AKAIEK 1511

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1403 TREAqlaLGNAAADATEAKNKAHEAEriasgVQKNATSTKADAERTFSEVTDLDNEVNGMLRQLEEAENELKRKQDDADQ 1482
Cdd:TIGR01612 1512 NKEL---FEQYKKDVTELLNKYSALA-----IKNKFAKTKKDSEIIIKEIKDAHKKFILEAEKSEQKIKEIKKEKFRIED 1583

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1483 DMMMAGMASQAAQEAEL-------------NARKAKN-------------SVSSLLSQLTDLLEQLGQLDTVD--LNKLN 1534
Cdd:TIGR01612 1584 DAAKNDKSNKAAIDIQLslenfenkflkisDIKKKINdclketesiekkiSSFSIDSQDTELKENGDNLNSLQefLESLK 1663

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1535 EIEGSLNKAKDEMkvSDLDRKVSNLENEARKQEAailDYDRDIAEIIKDI-----HNLEDIKKTLP------TGCFNTPS 1603
Cdd:TIGR01612 1664 DQKKNIEDKKKEL--DELDSEIEKIEIDVDQHKK---NYEIGIIEKIKEIaiankEEIESIKELIEptienlISSFNTND 1738


                   ..
gi 281371490  1604 IE 1605
Cdd:TIGR01612 1739 LE 1740
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 825-874 5.71e-08

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 50.43  E-value: 5.71e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 281371490  825 PCQCNDNIDPNavGNCNRLTGECLkCIYNTAGFYCDRCKEGFFGNPLAPN 874
Cdd:cd00055     1 PCDCNGHGSLS--GQCDPGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQGG 47
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 1025-1522 7.01e-08

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 57.75  E-value: 7.01e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1025 GCqeCPACYRLVKDKvaehrvklQELESLIANLgtgdETVTdQAFEDRLKEAEREVTDLLREAQEV---KDVDQNLMDRL 1101
Cdd:TIGR00606  678 SC--CPVCQRVFQTE--------AELQEFISDL----QSKL-RLAPDKLKSTESELKKKEKRRDEMlglAPGRQSIIDLK 742

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1102 QRvnnslhsqisRLHNIRNTIEETGILAERARSRVESTEQLIEIASRELEKAKMAAANVSITQpestgepNNMTLLAEEA 1181
Cdd:TIGR00606  743 EK----------EIPELRNKLQKVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIME-------RFQMELKDVE 805

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1182 RRLAER-HKQEADDIVRVAKTANETSAEAYNlLLRTLAGENqtaleieELNRKyeqaknISQDLEKQAARVHEEAKRAGD 1260
Cdd:TIGR00606  806 RKIAQQaAKLQGSDLDRTVQQVNQEKQEKQH-ELDTVVSKI-------ELNRK------LIQDQQEQIQHLKSKTNELKS 871

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1261 KAVEIYASVAQltpvdSEALESEANKIKKEAADLDRLIDQK----LKDYEDLREDMRGKEHEV-KNLLEKGKAEQQTADQ 1335
Cdd:TIGR00606  872 EKLQIGTNLQR-----RQQFEEQLVELSTEVQSLIREIKDAkeqdSPLETFLEKDQQEKEELIsSKETSNKKAQDKVNDI 946

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1336 LlaradaakalaeeaakkgrntlQEANDILNNLKDFDRRVNDNKtaaeealrripainrtiaEANEKTREAQLALGNAAA 1415
Cdd:TIGR00606  947 K----------------------EKVKNIHGYMKDIENKIQDGK------------------DDYLKQKETELNTVNAQL 986

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1416 DATEAKNKAHEAERiasGVQKNATSTKADAERTfsevtdLDNEVNGMLRQLEEAENELKRKQDDADQDMMMAGMASQAAQ 1495
Cdd:TIGR00606  987 EECEKHQEKINEDM---RLMRQDIDTQKIQERW------LQDNLTLRKRENELKEVEEELKQHLKEMGQMQVLQMKQEHQ 1057

                          490       500
                   ....*....|....*....|....*..
gi 281371490  1496 EAELNARKAKNSVSSLLSQLTDLLEQL 1522
Cdd:TIGR00606 1058 KLEENIDLIKRNHVLALGRQKGYEKEI 1084
growth_prot_Scy NF041483
polarized growth protein Scy;
1067-1572 7.05e-08

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 57.53  E-value: 7.05e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1067 QAFEDRL-KEAEREVTDLL----REAQEVKDVDQNLMDRLQRvnnslhsQISRLhniRNTIEETgilAERARSrvESTEQ 1141
Cdd:NF041483  752 QAEAQRLvEEADRRATELVsaaeQTAQQVRDSVAGLQEQAEE-------EIAGL---RSAAEHA---AERTRT--EAQEE 816

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1142 LIEIASRELEKAKMAAANVSITQPESTGEpnnmtllAEEARRLAERHKQEA-DDIVRVAKTANETSAEAYNLLLRTLAGE 1220
Cdd:NF041483  817 ADRVRSDAYAERERASEDANRLRREAQEE-------TEAAKALAERTVSEAiAEAERLRSDASEYAQRVRTEASDTLASA 889

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1221 NQTALEIEELNRkyEQAKNISQDLEKQAARVHEEAKRAGDKAVEiyASVAQLTPVDSEALESEANKIKKEAADLDRLIDQ 1300
Cdd:NF041483  890 EQDAARTRADAR--EDANRIRSDAAAQADRLIGEATSEAERLTA--EARAEAERLRDEARAEAERVRADAAAQAEQLIAE 965

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1301 KLKDYEDLR--------------EDMRGKEHEVKNLLEkGKAEQQTADqllaradaakalaeeAAKKGRNTLQEANdiln 1366
Cdd:NF041483  966 ATGEAERLRaeaaetvgsaqqhaERIRTEAERVKAEAA-AEAERLRTE---------------AREEADRTLDEAR---- 1025

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1367 nlKDFDRRVNDnktAAEEALRripAINRTIAEANEKTREAQLALGNAAADATEAKNKA-----HEAERIAS--------- 1432
Cdd:NF041483 1026 --KDANKRRSE---AAEQADT---LITEAAAEADQLTAKAQEEALRTTTEAEAQADTMvgaarKEAERIVAeatvegnsl 1097

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1433 -------------GVQKNATSTKADAE----RTFSEVTDLDNevngmlRQLEEAENELKRKQDDADQdMMMAGMASQAAQ 1495
Cdd:NF041483 1098 vekartdadellvGARRDATAIRERAEelrdRITGEIEELHE------RARRESAEQMKSAGERCDA-LVKAAEEQLAEA 1170

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 281371490 1496 EAelnarKAKNSVSSLLSQLTdlleqlgqldTVDLNKLNEIEGSLNKAkdEMKVSDLDRKVSNLENEARKQEAAILD 1572
Cdd:NF041483 1171 EA-----KAKELVSDANSEAS----------KVRIAAVKKAEGLLKEA--EQKKAELVREAEKIKAEAEAEAKRTVE 1230
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 1040-1562 1.23e-07

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 56.90  E-value: 1.23e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1040 VAEHRVKLQELESLIANLGTGDETVTDQAFED--RLKEAEREVTDL--LREAQEVKDVDQNLMdrlqrvnNSLHSQISRL 1115
Cdd:TIGR00618  333 HVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVAtsIREISCQQHTLTqhIHTLQQQKTTLTQKL-------QSLCKELDIL 405

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1116 HNIRNTIEetgilAERARSRVESTEQLIEIASRELEKAKMAAANVSITQpESTGEPNNMTLLAEEARRLAER-------- 1187
Cdd:TIGR00618  406 QREQATID-----TRTSAFRDLQGQLAHAKKQQELQQRYAELCAAAITC-TAQCEKLEKIHLQESAQSLKEReqqlqtke 479

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1188 --HKQEADDIVRVAKTANET--------------SAEAYNLLL------RTLAGENQTALEIEELNRKYEQAknisQDLE 1245
Cdd:TIGR00618  480 qiHLQETRKKAVVLARLLELqeepcplcgscihpNPARQDIDNpgpltrRMQRGEQTYAQLETSEEDVYHQL----TSER 555

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1246 KQAARVHEEAKRAgDKAVEIYASVAQLTPVDSEALESEANKIKKEAADLDRLIDQKLkdyEDLREDMRGKEHEVkNLLEK 1325
Cdd:TIGR00618  556 KQRASLKEQMQEI-QQSFSILTQCDNRSKEDIPNLQNITVRLQDLTEKLSEAEDMLA---CEQHALLRKLQPEQ-DLQDV 630

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1326 GKAEQQTADQLLARADAAKALAEeaakkgrNTLQEANDI-LNNLKDFDRRVNDNKTAAEEAL----RRIPAINRTIAEAN 1400
Cdd:TIGR00618  631 RLHLQQCSQELALKLTALHALQL-------TLTQERVREhALSIRVLPKELLASRQLALQKMqsekEQLTYWKEMLAQCQ 703

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1401 EKTR--------------EAQLALGNAAADaTEAKNKAH-----EAERIASGVQKNATSTKADA-------ERTFSEVTD 1454
Cdd:TIGR00618  704 TLLRelethieeydrefnEIENASSSLGSD-LAAREDALnqslkELMHQARTVLKARTEAHFNNneevtaaLQTGAELSH 782

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1455 LDNEVNGMLRQLEEAENELKRKQD------DADQDMMMAGMASQAAQEAELNARKAKNsvSSLLSQLTDLLEQLG----Q 1524
Cdd:TIGR00618  783 LAAEIQFFNRLREEDTHLLKTLEAeigqeiPSDEDILNLQCETLVQEEEQFLSRLEEK--SATLGEITHQLLKYEecskQ 860

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|
gi 281371490  1525 LDTVDLN--KLNEIEGSLNkAKDEMKVSDLDRKVSNLENE 1562
Cdd:TIGR00618  861 LAQLTQEqaKIIQLSDKLN-GINQIKIQFDGDALIKFLHE 899
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1395-1588 1.60e-07

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 55.61  E-value: 1.60e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1395 TIAEANEKTREAQLALGNAAADATEAKNKAHEAeriasgvQKNATSTKADAERTFSEVTDLDNEVNGMLRQLEEAENELK 1474
Cdd:COG3883    10 TPAFADPQIQAKQKELSELQAELEAAQAELDAL-------QAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1475 RKQDDADQDMmmagmasQAAQEAELNArkakNSVSSLLSQ--LTDLLEQLGQLDTV-------------DLNKLNEIEGS 1539
Cdd:COG3883    83 ERREELGERA-------RALYRSGGSV----SYLDVLLGSesFSDFLDRLSALSKIadadadlleelkaDKAELEAKKAE 151

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 281371490 1540 LNKAKDEM--KVSDLDRKVSNLENEARKQEAAILDYDRDIAEIIKDIHNLE 1588
Cdd:COG3883   152 LEAKLAELeaLKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELE 202
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1226-1510 2.08e-07

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 55.22  E-value: 2.08e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1226 EIEELNRKYEQAKNISQDLEKQAARVHEEAkragdkaveiyasvaqltpvdsEALESEANKIKKEAADLDRLIDQKLKDY 1305
Cdd:COG3883    17 QIQAKQKELSELQAELEAAQAELDALQAEL----------------------EELNEEYNELQAELEALQAEIDKLQAEI 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1306 EDLREDMRGKEHEVKNLLekgKAEQQTADQLLARadaakalaeeaakkgrNTLQEANDIlnnlKDFDRRVNDNKTAAEEA 1385
Cdd:COG3883    75 AEAEAEIEERREELGERA---RALYRSGGSVSYL----------------DVLLGSESF----SDFLDRLSALSKIADAD 131

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1386 LRRIPAINRTIAEANEKTREAQLALGNAAADATEAKNKaheaeriasgvQKNATSTKADAErtfSEVTDLDNEVNGMLRQ 1465
Cdd:COG3883   132 ADLLEELKADKAELEAKKAELEAKLAELEALKAELEAA-----------KAELEAQQAEQE---ALLAQLSAEEAAAEAQ 197

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 281371490 1466 LEEAENELKRKQDDADQDMMMAGMASQAAQEAELNARKAKNSVSS 1510
Cdd:COG3883   198 LAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA 242
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1427-1589 2.11e-07

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 54.91  E-value: 2.11e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1427 AERIASGVQKNATSTKADAERTFSEVTDLDNEVNGMLRQLEEAENELKRKQDDADQdmmmagMASQAAQ-EAELNARKAK 1505
Cdd:COG4372     1 GDRLGEKVGKARLSLFGLRPKTGILIAALSEQLRKALFELDKLQEELEQLREELEQ------AREELEQlEEELEQARSE 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1506 -NSVSSLLSQLTDLLEQLGQLDTVDLNKLNEIEGSLNKAKDEmkVSDLDRKVSNLENEARKQEAAILDYDRDIAEIIKDI 1584
Cdd:COG4372    75 lEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEE--LEELQKERQDLEQQRKQLEAQIAELQSEIAEREEEL 152


                  ....*
gi 281371490 1585 HNLED 1589
Cdd:COG4372   153 KELEE 157
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1105-1594 2.29e-07

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 55.80  E-value: 2.29e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1105 NNSLHSQISRLHNIRNTIEETgilaerarsrVESTEQLIEIASRELEKAKmaaanvsiTQPESTGEPNNmtllaEEARRL 1184
Cdd:TIGR04523  213 NKSLESQISELKKQNNQLKDN----------IEKKQQEINEKTTEISNTQ--------TQLNQLKDEQN-----KIKKQL 269

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1185 AERHKQeaddivrvAKTANETSAEAYNLLlrtlageNQTALEIEELNRKYEQaknisqDLEKQaarVHEEAKRAGDKAVE 1264
Cdd:TIGR04523  270 SEKQKE--------LEQNNKKIKELEKQL-------NQLKSEISDLNNQKEQ------DWNKE---LKSELKNQEKKLEE 325

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1265 IYASVAQLTPVDSEaLESEANKIKKEAADL-------DRLIDQKLKDYEDLREDMRGKEHEVKNLlekgkaEQQTADQll 1337
Cdd:TIGR04523  326 IQNQISQNNKIISQ-LNEQISQLKKELTNSesensekQRELEEKQNEIEKLKKENQSYKQEIKNL------ESQINDL-- 396

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1338 aradaakalaeeaakkgRNTLQEaNDILNNLKDfdRRVNDNKTAAEEALRRIPAINRTIAEANEKTREAqlalgnaaada 1417
Cdd:TIGR04523  397 -----------------ESKIQN-QEKLNQQKD--EQIKKLQQEKELLEKEIERLKETIIKNNSEIKDL----------- 445

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1418 teaKNKAHEAERIAsgvqKNATSTKADAERTFSEVTDLDNEVNgmlRQLEEAENELKRKQDDADqdmmmagMASQAAQEA 1497
Cdd:TIGR04523  446 ---TNQDSVKELII----KNLDNTRESLETQLKVLSRSINKIK---QNLEQKQKELKSKEKELK-------KLNEEKKEL 508

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1498 ELNARKAKNSVSSLLSQLTDLLEQLGQLDT--VDLN-KLNEIEGSLNKAKDEMKVSDLDRKVS-------NLENEARKQE 1567
Cdd:TIGR04523  509 EEKVKDLTKKISSLKEKIEKLESEKKEKESkiSDLEdELNKDDFELKKENLEKEIDEKNKEIEelkqtqkSLKKKQEEKQ 588

                          490       500
                   ....*....|....*....|....*..
gi 281371490  1568 AAILDYDRDIAEIIKDIHNLEDIKKTL 1594
Cdd:TIGR04523  589 ELIDQKEKEKKDLIKEIEEKEKKISSL 615
Borrelia_P83 pfam05262
Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.
 1061-1283 3.72e-07

Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.


Pssm-ID: 114011 [Multi-domain]  Cd Length: 489  Bit Score: 54.62  E-value: 3.72e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1061 DETVTDQAFEDRLKEAE--REVTDLL-REAQEVKDVDQNLMDRLQRvnnslhsqisrlhnirntieeTGILAERARSRVE 1137
Cdd:pfam05262  179 DKKVVEALREDNEKGVNfrRDMTDLKeRESQEDAKRAQQLKEELDK---------------------KQIDADKAQQKAD 237

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1138 STEQLIEIASRELEKAKMAAANVSitQPESTGEPNNMTLLAEEARRLAERHKQEADDIVRVAKTANETSAEAynlLLRTL 1217
Cdd:pfam05262  238 FAQDNADKQRDEVRQKQQEAKNLP--KPADTSSPKEDKQVAENQKREIEKAQIEIKKNDEEALKAKDHKAFD---LKQES 312

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 281371490  1218 AGENQTAlEIEELNRKYEQaKNISQDLEKQAARVHEEAKRAGDKAVEIYASVAQLTPVDSEALESE 1283
Cdd:pfam05262  313 KASEKEA-EDKELEAQKKR-EPVAEDLQKTKPQVEAQPTSLNEDAIDSSNPVYGLKVVDPITNLSE 376
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 1069-1592 3.78e-07

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 55.23  E-value: 3.78e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1069 FEDRLKEAEREVtDLLREAQevKDVDQNLMDRLQRVNNSLHSQISRLHNIRNTIEETgilAERARSRVESTEQLIEIASR 1148
Cdd:pfam12128  352 WQSELENLEERL-KALTGKH--QDVTAKYNRRRSKIKEQNNRDIAGIKDKLAKIREA---RDRQLAVAEDDLQALESELR 425

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1149 ELEKAKMAAANVSITQPESTGEPNNMTL---LAEEARRLAERHKQEADDIVRVAKTANETSAEAYNLLLRTLAGENQTAL 1225
Cdd:pfam12128  426 EQLEAGKLEFNEEEYRLKSRLGELKLRLnqaTATPELLLQLENFDERIERAREEQEAANAEVERLQSELRQARKRRDQAS 505

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1226 E-IEELNRKYEQAKNISQDLEKQ----AARVHE-EAKRAGDKAVEI--YASVAQL-----TPVDSEALESEANKIKKEAA 1292
Cdd:pfam12128  506 EaLRQASRRLEERQSALDELELQlfpqAGTLLHfLRKEAPDWEQSIgkVISPELLhrtdlDPEVWDGSVGGELNLYGVKL 585

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1293 DLDRLidqKLKDYEDLREDMRGKEHEVKNLLEKGKAEQQTADQLLARADAAKALAEEAAKKGRNTLQEANDILNNLKDFD 1372
Cdd:pfam12128  586 DLKRI---DVPEWAASEEELRERLDKAEEALQSAREKQAAAEEQLVQANGELEKASREETFARTALKNARLDLRRLFDEK 662

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1373 RRVNDNKT--------AAEEALRRIPA---------------INRTIAEAN----------EKTREAQLALGNAAADATE 1419
Cdd:pfam12128  663 QSEKDKKNkalaerkdSANERLNSLEAqlkqldkkhqawleeQKEQKREARtekqaywqvvEGALDAQLALLKAAIAARR 742

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1420 AKNKAHeaeriASGVQK-NATSTKA---DAERtfseVTDLDNEVNGMLRQLEEAEnelKRKQDDADQDMMMAGMASQAAQ 1495
Cdd:pfam12128  743 SGAKAE-----LKALETwYKRDLASlgvDPDV----IAKLKREIRTLERKIERIA---VRRQEVLRYFDWYQETWLQRRP 810

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1496 EAELNARKAKNSVSSLLSQLTDLLEqlgqlDT-VDLNKLNEIEGSLNKAKDEM-----KVSDLDRKVSNLENEARKQEAA 1569
Cdd:pfam12128  811 RLATQLSNIERAISELQQQLARLIA-----DTkLRRAKLEMERKASEKQQVRLsenlrGLRCEMSKLATLKEDANSEQAQ 885

                          570       580
                   ....*....|....*....|....*.
gi 281371490  1570 I-LDYDRDIAEIIKDIHN--LEDIKK 1592
Cdd:pfam12128  886 GsIGERLAQLEDLKLKRDylSESVKK 911
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1355-1595 4.54e-07

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 54.92  E-value: 4.54e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1355 RNTLQEANDILNNLKDFDRRVNDNKTAAE--EALRRIPAINRTIAEANEKTREAQLALgnAAADATEAKNKAHEAERIAS 1432
Cdd:COG4913   221 PDTFEAADALVEHFDDLERAHEALEDAREqiELLEPIRELAERYAAARERLAELEYLR--AALRLWFAQRRLELLEAELE 298

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1433 GVQKNATSTKADAERTFSEVTDLDNEVNGMLRQLEEA----ENELKRKQDDAdqdmmmagmasqaaqEAELNARKAKnsv 1508
Cdd:COG4913   299 ELRAELARLEAELERLEARLDALREELDELEAQIRGNggdrLEQLEREIERL---------------ERELEERERR--- 360

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1509 sslLSQLTDLLEQLGQldtvdlnKLNEIEGSLNKAKDEMK--VSDLDRKVSNLENEARKQEAAILDYDRDIAEIIKDIHN 1586
Cdd:COG4913   361 ---RARLEALLAALGL-------PLPASAEEFAALRAEAAalLEALEEELEALEEALAEAEAALRDLRRELRELEAEIAS 430


                  ....*....
gi 281371490 1587 LEDIKKTLP 1595
Cdd:COG4913   431 LERRKSNIP 439
CHASE3 COG5278
Extracytoplasmic sensor domain CHASE3 (specificity unknown) [Signal transduction mechanisms];
1046-1458 4.92e-07

Extracytoplasmic sensor domain CHASE3 (specificity unknown) [Signal transduction mechanisms];


Pssm-ID: 444089 [Multi-domain]  Cd Length: 530  Bit Score: 54.53  E-value: 4.92e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1046 KLQELESLIANLGTGDetvTDQAFEDRLKEAEREVTDLLREAQEVKDVDQNLMDRLQRVNNSLHSQISRLHNIRNTIEET 1125
Cdd:COG5278   119 WLAELEQVIALRRAGG---LEAALALVRSGEGKALMDEIRARLLLLALALAALLLAAAALLLLLLALAALLALAELLLLA 195

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1126 GILAERARSRVESTEQLIEIASRELEKAKMAAANVSITQPESTGEPNNMTLLAEEARRLAERHKQEADDIVRVAKTANET 1205
Cdd:COG5278   196 LARALAALLLLLLLEAELAAAAALLAAAAALAALAALELLAALALALALLLAALLLALLAALALAALLAAALLALAALLL 275

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1206 SAEAYNLLLRTLAGENQTALEIEELNRKYEQAKNISQDLEKQAARVHEEAKRAGDKAVEIYASVAQLTPVDSEALESEAN 1285
Cdd:COG5278   276 ALAAAAALAAAAALELAAAEALALAELELELLLAAAAAAAAAAAAAAAALAALLALALATALAAAAAALALLAALLAEAA 355

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1286 KIKKEAADLDRLIDQKLKDYEDLREDMRGKEHEVKNLLEKGKAEQQTADQLLARADAAKALAEEAAKKGRNTLQEANDIL 1365
Cdd:COG5278   356 AAAAEEAEAAAEAAAAALAGLAEVEAEGAAEAVELEVLAIAAAAAAAAAEAAAAAAAAAAASAAEALELAEALAEALALA 435

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1366 NNLKDFDRRVNDNKTAAEEALRRIPAINRTIAEANEKTREAQLALGNAAADATEAKNKAHEAERIASGVQKNATSTKADA 1445
Cdd:COG5278   436 EEEALALAAASSELAEAGAALALAAAEALAEELAAVAALAALAAAAAALAEAEAAAALAAAAALSLALALAALLLAAAEA 515

                         410
                  ....*....|...
gi 281371490 1446 ERTFSEVTDLDNE 1458
Cdd:COG5278   516 ALAAALAAALASA 528
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1070-1596 5.01e-07

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 54.64  E-value: 5.01e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1070 EDRLKEAEREV----TDLLREAQEVKDVDQNLMDRLQRVNNS------LHSQISRLHNiRNTIEETGIlaerarsrVEST 1139
Cdd:TIGR04523   32 DTEEKQLEKKLktikNELKNKEKELKNLDKNLNKDEEKINNSnnkikiLEQQIKDLND-KLKKNKDKI--------NKLN 102

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1140 EQLIEIASrelekakmaaanvsitqpESTGEPNNMTLLAEEARRLaERHKQEADdivrvaKTANETSAEAYNLllrtlag 1219
Cdd:TIGR04523  103 SDLSKINS------------------EIKNDKEQKNKLEVELNKL-EKQKKENK------KNIDKFLTEIKKK------- 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1220 ENQTAL---EIEELNRKYEQAKNISQDLEKQAARVHEEAKRAGDK--AVEIYASVAQLTPVDSEALESEANKIKKEAADL 1294
Cdd:TIGR04523  151 EKELEKlnnKYNDLKKQKEELENELNLLEKEKLNIQKNIDKIKNKllKLELLLSNLKKKIQKNKSLESQISELKKQNNQL 230

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1295 DRLIDQKLKDYEDLredmrgkehevknllekgKAEQQTADQLLAradaakalaeeaakkgrNTLQEANDILNNLKDFDRR 1374
Cdd:TIGR04523  231 KDNIEKKQQEINEK------------------TTEISNTQTQLN-----------------QLKDEQNKIKKQLSEKQKE 275

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1375 VNDNKTAAEEALRRIPAINRTIAEANeKTREAQLaLGNAAADATEAKNKAHEAERIASGVQKNATSTKADAERTFSEVTD 1454
Cdd:TIGR04523  276 LEQNNKKIKELEKQLNQLKSEISDLN-NQKEQDW-NKELKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTN 353

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1455 LDNEVNGMLRQLEEAENELKRKQDDadqdmmmagmasqaaqeaelNARKaKNSVSSLLSQLTDLLEQLGQLDTVDLNKLN 1534
Cdd:TIGR04523  354 SESENSEKQRELEEKQNEIEKLKKE--------------------NQSY-KQEIKNLESQINDLESKIQNQEKLNQQKDE 412

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 281371490  1535 EIEgSLNKAKDEmkvsdLDRKVSNLENEARKQEAAILDYDRDIAEIIKDIHNLEDIKKTLPT 1596
Cdd:TIGR04523  413 QIK-KLQQEKEL-----LEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLET 468
PRK12704 PRK12704
phosphodiesterase; Provisional
 1371-1593 5.15e-07

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 54.40  E-value: 5.15e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1371 FDRRVNDNK-TAAEEALRRIpaINRTIAEANEKTREAQLalgnaaadatEAKNKAHEAeriasgvqknatstKADAERtf 1449
Cdd:PRK12704   24 VRKKIAEAKiKEAEEEAKRI--LEEAKKEAEAIKKEALL----------EAKEEIHKL--------------RNEFEK-- 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1450 sEVTDLDNEVNGMLRQLEEAENELKRKQDDADQdmmmagmasqaaQEAELNARkaKNSVSSLLSQLTDLLEQLGQLDTVD 1529
Cdd:PRK12704   76 -ELRERRNELQKLEKRLLQKEENLDRKLELLEK------------REEELEKK--EKELEQKQQELEKKEEELEELIEEQ 140

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 281371490 1530 LNKLNEIEG-SLNKAKDEMkvsdldrkVSNLENEARkqeaaildydRDIAEIIKDIHnlEDIKKT 1593
Cdd:PRK12704  141 LQELERISGlTAEEAKEIL--------LEKVEEEAR----------HEAAVLIKEIE--EEAKEE 185
growth_prot_Scy NF041483
polarized growth protein Scy;
1049-1514 6.33e-07

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 54.45  E-value: 6.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1049 ELESLIANLGTGDETVTDQAFEDRLKEAEREVTDLLREAQE-VKDVDQNLMDRLQRVNNSLHSQISRLHNIRNTIEE--- 1124
Cdd:NF041483  342 EAEKLVAEAAEKARTVAAEDTAAQLAKAARTAEEVLTKASEdAKATTRAAAEEAERIRREAEAEADRLRGEAADQAEqlk 421

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1125 -------------TGILAERARSRVESTEQLIEIASRELEKAKMAAANVSITQPESTgepnnmtllAEEARRLAERHKQE 1191
Cdd:NF041483  422 gaakddtkeyrakTVELQEEARRLRGEAEQLRAEAVAEGERIRGEARREAVQQIEEA---------ARTAEELLTKAKAD 492

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1192 ADDIVRVAKTANETsaeaynllLRTLAGENQTAL--EIEE-LNRKYEQAKNISQDLEKQAARVHEEAKRAG-------DK 1261
Cdd:NF041483  493 ADELRSTATAESER--------VRTEAIERATTLrrQAEEtLERTRAEAERLRAEAEEQAEEVRAAAERAArelreetER 564

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1262 AVEIYASVA--QLTPVDSEALE-------------SEANKIKKEAAD-LDRLidqKLKDYEDLREDMRGKEHEVKNLLEK 1325
Cdd:NF041483  565 AIAARQAEAaeELTRLHTEAEErltaaeealadarAEAERIRREAAEeTERL---RTEAAERIRTLQAQAEQEAERLRTE 641

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1326 GKAEQQTADqllaradaakalaeeaakkgrntlQEANDILNNLKDfdrrvndnkTAAEEALRRipainRTIA-EANEKTR 1404
Cdd:NF041483  642 AAADASAAR------------------------AEGENVAVRLRS---------EAAAEAERL-----KSEAqESADRVR 683

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1405 -EAQLALGNAAADATEAKNKAH-EAERIASGVQKNATSTKADAERTFSEVTDLDNEVNGMLR-QLEEAENELKRKQDDAD 1481
Cdd:NF041483  684 aEAAAAAERVGTEAAEALAAAQeEAARRRREAEETLGSARAEADQERERAREQSEELLASARkRVEEAQAEAQRLVEEAD 763

                         490       500       510
                  ....*....|....*....|....*....|...
gi 281371490 1482 QdmmmagMASQAAQEAELNARKAKNSVSSLLSQ 1514
Cdd:NF041483  764 R------RATELVSAAEQTAQQVRDSVAGLQEQ 790
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 1034-1579 6.56e-07

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 54.41  E-value: 6.56e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1034 RLVKDKVAEHRVKLQELESLIANLGT----GDETVTDqaFEDRLKEAERevtdlLREAQEvkdvdqNLMDRLQRVNNSLH 1109
Cdd:pfam01576  155 KLLEERISEFTSNLAEEEEKAKSLSKlknkHEAMISD--LEERLKKEEK-----GRQELE------KAKRKLEGESTDLQ 221

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1110 SQISRLhniRNTIEEtgILAERARSRVESTEQLieiASRELEKAKMAAANVSITQPESTGEPNNMTLLAEE-ARRLAERH 1188
Cdd:pfam01576  222 EQIAEL---QAQIAE--LRAQLAKKEEELQAAL---ARLEEETAQKNNALKKIRELEAQISELQEDLESERaARNKAEKQ 293

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1189 KQEADDIVRVAKTANETSAEAYN--------------LLLRTLAGENQT------------ALEIEELNRKYEQAKNISQ 1242
Cdd:pfam01576  294 RRDLGEELEALKTELEDTLDTTAaqqelrskreqevtELKKALEEETRSheaqlqemrqkhTQALEELTEQLEQAKRNKA 373

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1243 DLEK-------------------QAARVHEEAKR-----------------------AGDKAVEIYASVAQLTPVDSEAl 1280
Cdd:pfam01576  374 NLEKakqalesenaelqaelrtlQQAKQDSEHKRkklegqlqelqarlseserqraeLAEKLSKLQSELESVSSLLNEA- 452

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1281 ESEANKIKKEAADLD-RLID----------QKL------KDYED----LREDMRGKEHEVKNL----------------- 1322
Cdd:pfam01576  453 EGKNIKLSKDVSSLEsQLQDtqellqeetrQKLnlstrlRQLEDernsLQEQLEEEEEAKRNVerqlstlqaqlsdmkkk 532

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1323 ----------LEKGKAEQQTADQLLARADAAKALAEEAAKKGRNTLQEAND-----------ILNNL----KDFDRRVND 1377
Cdd:pfam01576  533 leedagtleaLEEGKKRLQRELEALTQQLEEKAAAYDKLEKTKNRLQQELDdllvdldhqrqLVSNLekkqKKFDQMLAE 612

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1378 NKTA----AEEAlrripaiNRTIAEANEKTREAqLALGNAAADATEAKNKAHEAERIASGVQKNATSTKADAERTFSEVT 1453
Cdd:pfam01576  613 EKAIsaryAEER-------DRAEAEAREKETRA-LSLARALEEALEAKEELERTNKQLRAEMEDLVSSKDDVGKNVHELE 684

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1454 D----LDNEVNGMLRQLEEAENELKrKQDDADQDMMMAGMASQAAQEAELNARKAKNSVS--SLLSQLTDLLEQLgqldt 1527
Cdd:pfam01576  685 RskraLEQQVEEMKTQLEELEDELQ-ATEDAKLRLEVNMQALKAQFERDLQARDEQGEEKrrQLVKQVRELEAEL----- 758

                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 281371490  1528 vDLNKLNEIEGSLNKAKDEMKVSDLDRKVSNL---ENEARKQ----EAAILDYDRDIAE 1579
Cdd:pfam01576  759 -EDERKQRAQAVAAKKKLELDLKELEAQIDAAnkgREEAVKQlkklQAQMKDLQRELEE 816
ClyA_Cry6Aa-like cd22656
Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes ...
 1192-1333 8.71e-07

Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes pesticidal Cry6Aa toxin from Bacillus thuringiensis, one of the many parasporal crystal (Cry) toxins produced during the sporulation phase of growth. Many of these proteins are toxic to numerous insect species and have been effectively used as proteinaceous insecticides to directly kill insect pests; some have been used to control insect growth on transgenic agricultural plants. Cry6Aa exists as a protoxin, which is activated by cleavage using trypsin. Structure studies for Cry6Aa support a mechanism of action by pore formation, similar to cytolysin A (ClyA)-type alpha pore-forming toxins (alpha-PFTs) such as HblB, and bioassay and mutation studies show that Cry6Aa is an active pore-forming toxin. Cry6Aa shows atypical features compared to other members of alpha-PFTs, including internal repeat sequences and small loop regions within major alpha helices.


Pssm-ID: 439154 [Multi-domain]  Cd Length: 309  Bit Score: 52.76  E-value: 8.71e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1192 ADDIVRVAKTANETSAEAYNLLLRtLAGENQTALEIEELNRKYEQAKNISQDLEKQAARVHEEAKRAGDKaveiYASVAQ 1271
Cdd:cd22656    75 AGDIYNYAQNAGGTIDSYYAEILE-LIDDLADATDDEELEEAKKTIKALLDDLLKEAKKYQDKAAKVVDK----LTDFEN 149

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 281371490 1272 LTPVDSEALESEANKIKK---------EAADLDRLIDQKLKDYEDLREDMRGKEHEVKNLLEKGKAEQQTA 1333
Cdd:cd22656   150 QTEKDQTALETLEKALKDlltdeggaiARKEIKDLQKELEKLNEEYAAKLKAKIDELKALIADDEAKLAAA 220
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1071-1335 8.88e-07

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 53.92  E-value: 8.88e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1071 DRLKEAEREVTDLLREAQEVKdvdqNLMDRLQRVNNSLHSQISRLHNIRNTIEETgilAERARSRVESTEQLIEIASREL 1150
Cdd:TIGR02169  681 ERLEGLKRELSSLQSELRRIE----NRLDELSQELSDASRKIGEIEKEIEQLEQE---EEKLKERLEELEEDLSSLEQEI 753

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1151 E--KAKMAAANVSITQPESTgepnnmtlLAEEARRLAERHKQEADDIVR-VAKTANETSAEAYNLLLRTLAGENqtalEI 1227
Cdd:TIGR02169  754 EnvKSELKELEARIEELEED--------LHKLEEALNDLEARLSHSRIPeIQAELSKLEEEVSRIEARLREIEQ----KL 821

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1228 EELNRKYEQAKNISQDLEKQaaRVHEEAKRAGDKAvEIYASVAQLtpvdsEALESEANKIKKEAADLD-RLIDQKlKDYE 1306
Cdd:TIGR02169  822 NRLTLEKEYLEKEIQELQEQ--RIDLKEQIKSIEK-EIENLNGKK-----EELEEELEELEAALRDLEsRLGDLK-KERD 892

                          250       260
                   ....*....|....*....|....*....
gi 281371490  1307 DLREDMRgkehEVKNLLEKGKAEQQTADQ 1335
Cdd:TIGR02169  893 ELEAQLR----ELERKIEELEAQIEKKRK 917
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1052-1310 9.13e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 53.23  E-value: 9.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1052 SLIANLGTGDETVTDQAFEDRLKEAEREVTDLLREAQEVKDVDQNLMDRLQRVNNSLHSQISRLHNIRNTIEETgilaer 1131
Cdd:COG4942     8 ALLLALAAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAAL------ 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1132 aRSRVESTEQLIEIASRELEKAKMAAANVSITQpESTGEPNNMTLLAeearrlaerHKQEADDIVRvaktanetSAEAYN 1211
Cdd:COG4942    82 -EAELAELEKEIAELRAELEAQKEELAELLRAL-YRLGRQPPLALLL---------SPEDFLDAVR--------RLQYLK 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1212 LLLRTLAGE-NQTALEIEELNRKYEQAKNISQDLEKQAARVhEEAKRAGDKAVEIYASVAQLTPVDSEALESEANKIKKE 1290
Cdd:COG4942   143 YLAPARREQaEELRADLAELAALRAELEAERAELEALLAEL-EEERAALEALKAERQKLLARLEKELAELAAELAELQQE 221

                         250       260
                  ....*....|....*....|
gi 281371490 1291 AADLDRLIDQKLKDYEDLRE 1310
Cdd:COG4942   222 AEELEALIARLEAEAAAAAE 241
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1359-1525 1.13e-06

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 52.91  E-value: 1.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1359 QEANDILNNLKDFDRRVNDNKTAAEEAL-------RRIPAINRTIAEANEKTREAQLALGNAAADATEAKNKAHEAERIA 1431
Cdd:COG3883    30 AELEAAQAELDALQAELEELNEEYNELQaelealqAEIDKLQAEIAEAEAEIEERREELGERARALYRSGGSVSYLDVLL 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1432 sgvqkNATSTKADAER--TFSEVTDLDNEvngMLRQLEEAENELKRKQDDAD--QDMMMAGMASQAAQEAELNARKAKNS 1507
Cdd:COG3883   110 -----GSESFSDFLDRlsALSKIADADAD---LLEELKADKAELEAKKAELEakLAELEALKAELEAAKAELEAQQAEQE 181

                         170       180
                  ....*....|....*....|
gi 281371490 1508 --VSSLLSQLTDLLEQLGQL 1525
Cdd:COG3883   182 alLAQLSAEEAAAEAQLAEL 201
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 1067-1579 1.16e-06

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 53.64  E-value: 1.16e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1067 QAFEDRLKEAEREVTDLLREAQEVKDVDQNLMDRLQ---RVNNSLHSQISRLHNIRNTIEEtgILAErARSRVESTEQli 1143
Cdd:pfam01576   15 QKVKERQQKAESELKELEKKHQQLCEEKNALQEQLQaetELCAEAEEMRARLAARKQELEE--ILHE-LESRLEEEEE-- 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1144 eiASREL--EKAKMA--------------AANVSITQPESTGEP------NNMTLLAEEARRLAERHKQEADDIVRVAKT 1201
Cdd:pfam01576   90 --RSQQLqnEKKKMQqhiqdleeqldeeeAARQKLQLEKVTTEAkikkleEDILLLEDQNSKLSKERKLLEERISEFTSN 167

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1202 ANETSAEAYNLL-LRT------------LAGENQTALEIEELNRKYE--------------------QAKNISQDLEKQA 1248
Cdd:pfam01576  168 LAEEEEKAKSLSkLKNkheamisdleerLKKEEKGRQELEKAKRKLEgestdlqeqiaelqaqiaelRAQLAKKEEELQA 247

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1249 A--RVHEE--AKRAGDKAV-EIYASVAQLtpvdSEALESEA---NKIKKEAADLDRLIDQKLKDYED------LREDMRG 1314
Cdd:pfam01576  248 AlaRLEEEtaQKNNALKKIrELEAQISEL----QEDLESERaarNKAEKQRRDLGEELEALKTELEDtldttaAQQELRS 323

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1315 K-EHEV----KNLLEKGKA-EQQTAD--QLLARADAAKALAEEAAKKGRNTLQEANDIL----NNLKDFDRRVNDNKTAA 1382
Cdd:pfam01576  324 KrEQEVtelkKALEEETRShEAQLQEmrQKHTQALEELTEQLEQAKRNKANLEKAKQALesenAELQAELRTLQQAKQDS 403

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1383 EEALRRIPA-----------INRTIAEANEKTREAQLALGNAAADATEAKNKAHEAERIASGVQknatSTKADAERTFSE 1451
Cdd:pfam01576  404 EHKRKKLEGqlqelqarlseSERQRAELAEKLSKLQSELESVSSLLNEAEGKNIKLSKDVSSLE----SQLQDTQELLQE 479

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1452 VT-----------DLDNEVNGMLRQLEEAE-----------------NELKRKQDDadqdmmMAGmASQAAQEAElnaRK 1503
Cdd:pfam01576  480 ETrqklnlstrlrQLEDERNSLQEQLEEEEeakrnverqlstlqaqlSDMKKKLEE------DAG-TLEALEEGK---KR 549

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1504 AKNSVSSLLSQLTdllEQLGQLDtvdlnKLNEIEGSLNKAKDEMKVsDLDRK---VSNLENEARK------QEAAI---L 1571
Cdd:pfam01576  550 LQRELEALTQQLE---EKAAAYD-----KLEKTKNRLQQELDDLLV-DLDHQrqlVSNLEKKQKKfdqmlaEEKAIsarY 620


                   ....*...
gi 281371490  1572 DYDRDIAE 1579
Cdd:pfam01576  621 AEERDRAE 628
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 283-328 1.20e-06

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 46.96  E-value: 1.20e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 281371490  283 RCKCNGHASECVKNEFGKLVCNCKHNTYGVDCEKCLPFFNDRPWRR 328
Cdd:cd00055     1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQG 46
MDN1 COG5271
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ...
 1049-1568 2.38e-06

Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444083 [Multi-domain]  Cd Length: 1028  Bit Score: 52.71  E-value: 2.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1049 ELESLIANLGTGDETVTDQAFEDRLKEAEREVTDLLREAQEVKDVDQNLMDRLQRVNNSLhSQISRLHNIRNTIEETGIL 1128
Cdd:COG5271   156 LPSLADNDEAAADEGDELAADGDDTLAVADAIEATPGGTDAVELTATLGATVTTDPGDSV-AADDDLAAEEGASAVVEEE 234

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1129 AERARSRVESTEQLIEIASRELEKAKMAAANVSITQPESTGEPNNMTLLAEEARRLAERHKQEADDIVRVAKTANETSAE 1208
Cdd:COG5271   235 DASEDAVAAADETLLADDDDTESAGATAEVGGTPDTDDEATDDADGLEAAEDDALDAELTAAQAADPESDDDADDSTLAA 314

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1209 AYNLLLRTLAGENQTALEIEELNRKYEQAKNISQDLEKQAARVHEEAKRAGDKAVEIYASVAQLTPVDSEALESEANKIK 1288
Cdd:COG5271   315 LEGAAEDTEIATADELAAADDEDDDDSAAEDAAEEAATAEDSAAEDTQDAEDEAAGEAADESEGADTDAAADEADAAADD 394

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1289 KEAADLDRLIDQKLKDYEDLREdmrgkEHEVKNLLEKGKAEQQTADQLLARADAAKALAEEAAKKGRNTLQEANDILNNL 1368
Cdd:COG5271   395 SADDEEASADGGTSPTSDTDEE-----EEEADEDASAGETEDESTDVTSAEDDIATDEEADSLADEEEEAEAELDTEEDT 469

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1369 KDFDRRVNDNKTAAEEALR--RIPAINRTIAEANEKTREAQLALGNA-AADATEAKNKAHEAERIASGVQKNATSTKADA 1445
Cdd:COG5271   470 ESAEEDADGDEATDEDDASddGDEEEAEEDAEAEADSDELTAEETSAdDGADTDAAADPEDSDEDALEDETEGEENAPGS 549

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1446 ERTFSEVTDLDNEVNGMLRQLEEAENELKRKQDDADQDMMMAGMASQAAQEAELNARKAKNSVSSLLSQLTDLLEQLGQL 1525
Cdd:COG5271   550 DQDADETDEPEATAEEDEPDEAEAETEDATENADADETEESADESEEAEASEDEAAEEEEADDDEADADADGAADEEETE 629

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|...
gi 281371490 1526 DTVDLNKLNEIEGSLNKAKDEMkvSDLDRKVSNLENEARKQEA 1568
Cdd:COG5271   630 EEAAEDEAAEPETDASEAADED--ADAETEAEASADESEEEAE 670
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 1208-1595 3.50e-06

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 51.90  E-value: 3.50e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1208 EAYNLLLRTLAGENQTALEIEELNRKY----EQAKNISQDLEKQAARVHEEAKRAGDKAVEIYASVAQLTPVDSEALESE 1283
Cdd:pfam02463  173 EALKKLIEETENLAELIIDLEELKLQElklkEQAKKALEYYQLKEKLELEEEYLLYLDYLKLNEERIDLLQELLRDEQEE 252

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1284 ANKIKKEAADLDRLIDQKLKDYEdlredmrgKEHEVKNLLEKGKAEQQTAdqllaradaakalaeeaakkgRNTLQEAND 1363
Cdd:pfam02463  253 IESSKQEIEKEEEKLAQVLKENK--------EEEKEKKLQEEELKLLAKE---------------------EEELKSELL 303

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1364 ILNNLKDFDRRV-----NDNKTAAEEALRRIPAINRTIAEANEKTReAQLALGNAAADATEAKNKAHEAE-RIASGVQKN 1437
Cdd:pfam02463  304 KLERRKVDDEEKlkeseKEKKKAEKELKKEKEEIEELEKELKELEI-KREAEEEEEEELEKLQEKLEQLEeELLAKKKLE 382

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1438 ATSTKADAERTFSEVTDLDNEVNGMLRQLEEAENELKRKQDDADQDMMMAGMASQAAQEAELNARKAKNsvsSLLSQLTD 1517
Cdd:pfam02463  383 SERLSSAAKLKEEELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKE---ELEKQELK 459

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 281371490  1518 LLEQLGQLDTVDLNKLNEIEGSLNKAKDEMKVSDLDRKVSNLENEARKQEAAILDYDRDIAeiiKDIHNLEDIKKTLP 1595
Cdd:pfam02463  460 LLKDELELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGV---GGRIISAHGRLGDL 534
Laminin_I pfam06008
Laminin Domain I; coiled-coil structure. It has been suggested that the domains I and II from ...
 1385-1568 4.30e-06

Laminin Domain I; coiled-coil structure. It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure.


Pssm-ID: 310534 [Multi-domain]  Cd Length: 258  Bit Score: 50.10  E-value: 4.30e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1385 ALRRIPAINRTIAEANEKTREAQLALGNAAADATEAKNK----AHEAERIASGVQKN---ATSTKADAERTFSEVTDLDN 1457
Cdd:pfam06008   10 ALPAPYKINYNLENLTKQLQEYLSPENAHKIQIEILEKElsslAQETEELQKKATQTlakAQQVNAESERTLGHAKELAE 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1458 EVNGMLRQLEE---------------AENELKRKQDDADQdmMMAGMAS----QAAQEAELNARKAKNSVSSLLSQLTDL 1518
Cdd:pfam06008   90 AIKNLIDNIKEinekvatlgendfalPSSDLSRMLAEAQR--MLGEIRSrdfgTQLQNAEAELKAAQDLLSRIQTWFQSP 167

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 281371490  1519 LEQLGQLDTVDLNKLNEIEGSLNKAKD-----EMKVSDLDRKvsNLENEARKQEA 1568
Cdd:pfam06008  168 QEENKALANALRDSLAEYEAKLSDLREllreaAAKTRDANRL--NLANQANLREF 220
TolA COG3064
Membrane protein TolA involved in colicin uptake [Cell wall/membrane/envelope biogenesis];
1128-1597 5.13e-06

Membrane protein TolA involved in colicin uptake [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442298 [Multi-domain]  Cd Length: 485  Bit Score: 51.19  E-value: 5.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1128 LAERARSRVESTEQLIEIASRE-LEKAKMAAANVSITQPEstgepnnmtLLAEEARRLAERHKQEADDIVRVAKTANETS 1206
Cdd:COG3064    31 AEQKAKEEAEEERLAELEAKRQaEEEAREAKAEAEQRAAE---------LAAEAAKKLAEAEKAAAEAEKKAAAEKAKAA 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1207 AEAYNLLlrtlagENQTALEIEElNRKYEQAKnisQDLEKQAARVHEEAKRAGDKAVEIYASVAQLTPVDSEALESEANK 1286
Cdd:COG3064   102 KEAEAAA------AAEKAAAAAE-KEKAEEAK---RKAEEEAKRKAEEERKAAEAEAAAKAEAEAARAAAAAAAAAAAAA 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1287 IKKEAADLDRLIDQKLKDYEdlredmRGKEHEVKNLLEKGKAEQQTADQLLARADAAKALAEEAAKKGRNTLQEANDILN 1366
Cdd:COG3064   172 ARAAAGAAAALVAAAAAAVE------AADTAAAAAAALAAAAAAAAADAALLALAVAARAAAASREAALAAVEATEEAAL 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1367 NLKDFDRRVNDNKTAAEEALRRIPAINRTIAEANEkTREAQLALGNAAADATEAKNKAHEAERIASGVQKNATSTKADAE 1446
Cdd:COG3064   246 GGAEEAADLAAVGVLGAALAAAAAGAAALSSGLVV-VAAALAGLAAAAAGLVLDDSAALAAELLGAVAAEEAVLAAAAAA 324

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1447 RTfsevtdlDNEVNGMLRQLEEAENELKRKQDDADQDmmmAGMASQAAQEAELNARKAKNSVSSLLSQLTDLLEQLGQLD 1526
Cdd:COG3064   325 GA-------LVVRGGGAASLEAALSLLAAGAAAAAAG---AGALATGALGDALAAEAAGALLLGKLADVEEAAGAGILAA 394

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 281371490 1527 TVDLNKLNeIEGSLNKAKDEMKVSDLDRKVSNLENEARKQEAAILDYDRDIAEIIKDIHNLEDIKKTLPTG 1597
Cdd:COG3064   395 AGGGGLLG-LRLDLGAALLEAASAVELRVLLALAGAAGAVVALLVKLVADLAGGLVGIGKALTGDADALLG 464
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1037-1584 5.73e-06

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 51.45  E-value: 5.73e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1037 KDKVAEHRVKLQELESLIANLGTGDETvTDQAFEDRLKEAEREVTDLLREAQEVKDVDQNLMDRLQRVN----------N 1106
Cdd:COG4913   351 ERELEERERRRARLEALLAALGLPLPA-SAEEFAALRAEAAALLEALEEELEALEEALAEAEAALRDLRrelreleaeiA 429

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1107 SLHSQIS----RLHNIRNTI-EETGILAERARSRVEsteqLIEIASRE------LEKA---------------KMAAANV 1160
Cdd:COG4913   430 SLERRKSnipaRLLALRDALaEALGLDEAELPFVGE----LIEVRPEEerwrgaIERVlggfaltllvppehyAAALRWV 505

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1161 sitqpestgEPNNM-----TLLAEEARRLAERHKQEADDIVRVAKTAnETSAEAYnllLRTLAGENQTAL---EIEELnR 1232
Cdd:COG4913   506 ---------NRLHLrgrlvYERVRTGLPDPERPRLDPDSLAGKLDFK-PHPFRAW---LEAELGRRFDYVcvdSPEEL-R 571

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1233 KYEQAknISQD-LEKQAARVHEeaKRAGDKAVEIYA----SVAQLtpvdsEALESEANKIKKEAADLDRLID-------- 1299
Cdd:COG4913   572 RHPRA--ITRAgQVKGNGTRHE--KDDRRRIRSRYVlgfdNRAKL-----AALEAELAELEEELAEAEERLEaleaelda 642

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1300 --------QKLKDYEDLREDMRGKEHEVKNLlekgkaEQQtadqllaradaakalaeeaakkgRNTLQEANDILNNLKdf 1371
Cdd:COG4913   643 lqerrealQRLAEYSWDEIDVASAEREIAEL------EAE-----------------------LERLDASSDDLAALE-- 691

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1372 dRRVNDNKTAAEEALRRIPAINRTIAEANEKTREAQLALgNAAADATEAKNKAHEAERIASGVQKNATSTKADAERTFSE 1451
Cdd:COG4913   692 -EQLEELEAELEELEEELDELKGEIGRLEKELEQAEEEL-DELQDRLEAAEDLARLELRALLEERFAAALGDAVERELRE 769

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1452 vtDLDNEVNGMLRQLEEAENELKRKQDDADQDMMMAGMASQAAQEAelnarkaknsvssllsqLTDLLEQLGQLDTVDL- 1530
Cdd:COG4913   770 --NLEERIDALRARLNRAEEELERAMRAFNREWPAETADLDADLES-----------------LPEYLALLDRLEEDGLp 830

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....
gi 281371490 1531 NKLNEIEGSLNKAKDEmKVSDLDRKvsnLENEArkqeaaildydRDIAEIIKDI 1584
Cdd:COG4913   831 EYEERFKELLNENSIE-FVADLLSK---LRRAI-----------REIKERIDPL 869
PRK07352 PRK07352
F0F1 ATP synthase subunit B; Validated
 1387-1483 5.97e-06

F0F1 ATP synthase subunit B; Validated


Pssm-ID: 180941 [Multi-domain]  Cd Length: 174  Bit Score: 48.41  E-value: 5.97e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1387 RRIPAINRTIAEANEKTREAQLALGNAAADATEAKnkaHEAERIASGVQKNATSTKADAE-RTFSEV--------TDLDN 1457
Cdd:PRK07352   50 ERREAILQALKEAEERLRQAAQALAEAQQKLAQAQ---QEAERIRADAKARAEAIRAEIEkQAIEDMarlkqtaaADLSA 126

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 281371490 1458 E---VNGMLRQ------LEEAENELKRKQDDADQD 1483
Cdd:PRK07352  127 EqerVIAQLRReaaelaIAKAESQLPGRLDEDAQQ 161
Tropomyosin pfam00261
Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 ...
 1355-1585 7.94e-06

Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 parallel helices containing 2 sets of 7 alternating actin binding sites. The protein is best known for its role in regulating the interaction between actin and myosin in muscle contraction, but is also involved in the organization and dynamics of the cytoskeleton in non-muscle cells. There are multiple cell-specific isoforms, expressed by alternative promoters and alternative RNA processing of at least four genes. Muscle isoforms of tropomyosin are characterized by having 284 amino acid residues and a highly conserved N-terminal region, whereas non-muscle forms are generally smaller and are heterogeneous in their N-terminal region.


Pssm-ID: 459736 [Multi-domain]  Cd Length: 235  Bit Score: 48.87  E-value: 7.94e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1355 RNTLQEANDILNNLKDFDRRVNDNKTAAEEALRRIPAINRTIAEANEKTREAQLALGNAAADATEAKNKAHEAERIASGV 1434
Cdd:pfam00261    4 QQIKEELDEAEERLKEAMKKLEEAEKRAEKAEAEVAALNRRIQLLEEELERTEERLAEALEKLEEAEKAADESERGRKVL 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1435 QknaTSTKADAERtfsevtdldnevngmLRQLEEAENELKRKQDDADQDMMMAG----MASQAAQEAELNARKAKNSVSS 1510
Cdd:pfam00261   84 E---NRALKDEEK---------------MEILEAQLKEAKEIAEEADRKYEEVArklvVVEGDLERAEERAELAESKIVE 145

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1511 LLSQLTDLLEQLGQLDtVDLNKLNEIEGSL-NKAKD--------EMKVSDLDRKVSNLENEARKQEAAILDYDRDIAEII 1581
Cdd:pfam00261  146 LEEELKVVGNNLKSLE-ASEEKASEREDKYeEQIRFlteklkeaETRAEFAERSVQKLEKEVDRLEDELEAEKEKYKAIS 224


                   ....
gi 281371490  1582 KDIH 1585
Cdd:pfam00261  225 EELD 228
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1036-1335 8.41e-06

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 50.79  E-value: 8.41e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1036 VKDKVAEHRVKLQELESLIANLGT--GDETVTDQAFEDRLKEAEREVTDLLREAQEVKDVDQNlmdrlqrvnnsLHSQIS 1113
Cdd:TIGR04523  326 IQNQISQNNKIISQLNEQISQLKKelTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKN-----------LESQIN 394

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1114 RLhniRNTIEEtgilaerarsrVESTEQLIEIASRELEKAKmaaanvsitqpestgepnnmTLLAEEARRLAERHKQEAD 1193
Cdd:TIGR04523  395 DL---ESKIQN-----------QEKLNQQKDEQIKKLQQEK--------------------ELLEKEIERLKETIIKNNS 440

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1194 DIVRVAKTANETSAEAYNLLLRTLAGENQtaleIEELNRKYEQAKNISQDLEKQAARVHEEAKRAGDKAVEIYASVAQLT 1273
Cdd:TIGR04523  441 EIKDLTNQDSVKELIIKNLDNTRESLETQ----LKVLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKKELEEKVKDLT 516

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 281371490  1274 PVDS------EALESEANKIKKEAADLDRLI---DQKLKdYEDLREDMRGK-------EHEVKNLLEKGKAEQQTADQ 1335
Cdd:TIGR04523  517 KKISslkekiEKLESEKKEKESKISDLEDELnkdDFELK-KENLEKEIDEKnkeieelKQTQKSLKKKQEEKQELIDQ 593
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 1040-1333 9.00e-06

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 50.59  E-value: 9.00e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1040 VAEHRVKLQELESLIAN-----LGTGDETVTDQA----FEDRLKEAEREVTDLLRE----AQEVKDVDQ---NLMDRLQr 1103
Cdd:pfam10174  347 VDALRLRLEEKESFLNKktkqlQDLTEEKSTLAGeirdLKDMLDVKERKINVLQKKienlQEQLRDKDKqlaGLKERVK- 425

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1104 vnnSLHSQISRLHNIRNTIEETgiLAE-----------RARSRVESTEQLiEIASRELEKAKmaaANVSITQPESTGEPN 1172
Cdd:pfam10174  426 ---SLQTDSSNTDTALTTLEEA--LSEkeriierlkeqREREDRERLEEL-ESLKKENKDLK---EKVSALQPELTEKES 496

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1173 NMTLLAEEARRLAERHKQEaDDIVRVAKTANETSAEAYNlllrTLAGENQTALEIEELNRKYEQAKNISQDLEKQAARVH 1252
Cdd:pfam10174  497 SLIDLKEHASSLASSGLKK-DSKLKSLEIAVEQKKEECS----KLENQLKKAHNAEEAVRTNPEINDRIRLLEQEVARYK 571

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1253 EEAKRAgdkaveiYASVAQLTPVDSEAlESEANKIKKEAADLDRLIDQKLKDYEDLREDMRGKEHEVK----NLLEKGKA 1328
Cdd:pfam10174  572 EESGKA-------QAEVERLLGILREV-ENEKNDKDKKIAELESLTLRQMKEQNKKVANIKHGQQEMKkkgaQLLEEARR 643


                   ....*
gi 281371490  1329 EQQTA 1333
Cdd:pfam10174  644 REDNL 648
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1039-1606 1.08e-05

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 50.40  E-value: 1.08e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1039 KVAEHRVKLQELESLIANLGTGDETVTDQAFEDRLKEaereVTDLLREAQEVKDVDQNLMDRLQRVNNSLHSQISRLhni 1118
Cdd:TIGR04523  275 ELEQNNKKIKELEKQLNQLKSEISDLNNQKEQDWNKE----LKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQL--- 347

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1119 rntieetgilaERARSRVESTeqlieiasrelekakmaaaNVSITqpestgepnnmtllaeeaRRLAERHKQeaddIVRV 1198
Cdd:TIGR04523  348 -----------KKELTNSESE-------------------NSEKQ------------------RELEEKQNE----IEKL 375

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1199 AKTANETSAEAYNLllrtlagENQtaleIEELNRKYEQAKNISQDLEKQAarvheeakragdkaveiyasvaqltpvdsE 1278
Cdd:TIGR04523  376 KKENQSYKQEIKNL-------ESQ----INDLESKIQNQEKLNQQKDEQI-----------------------------K 415

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1279 ALESEANKIKKEAADLDRLIDQKLKDYEDLREDMRGKEHEVKNlLEKGKAEQQTadqllaradaakalaeeaakkgrntl 1358
Cdd:TIGR04523  416 KLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKN-LDNTRESLET-------------------------- 468

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1359 qeandilnNLKDFDRRVNDNKTAAEEALRRIPAINRTIAEANEKTREAQLALGNAAADATEAKNKaheaeriasgvQKNA 1438
Cdd:TIGR04523  469 --------QLKVLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKKELEEKVKDLTKKISSLKEK-----------IEKL 529

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1439 TSTKADAErtfSEVTDLDNEVNGMLRQLEeaENELKRKQDDADQdmmmagmasqaaqeaELNarKAKNSVSSLLS---QL 1515
Cdd:TIGR04523  530 ESEKKEKE---SKISDLEDELNKDDFELK--KENLEKEIDEKNK---------------EIE--ELKQTQKSLKKkqeEK 587

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1516 TDLLEQLgQLDTVDLNKlnEIEgslnkaKDEMKVSDLDRKVSNLENEARKQEAAILDYDRDIAEIIKDIHNledIKKTLP 1595
Cdd:TIGR04523  588 QELIDQK-EKEKKDLIK--EIE------EKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKLKQEVKQ---IKETIK 655

                          570
                   ....*....|.
gi 281371490  1596 TGCFNTPSIEK 1606
Cdd:TIGR04523  656 EIRNKWPEIIK 666
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1040-1583 1.08e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 50.30  E-value: 1.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1040 VAEHRVKLQELESLIANLGTGDETVTDQAFEDRLKEAEREVTDLLREAQEVKDvdqnLMDRLQRVNNSLHSQISRLHNIR 1119
Cdd:COG4913   257 IRELAERYAAARERLAELEYLRAALRLWFAQRRLELLEAELEELRAELARLEA----ELERLEARLDALREELDELEAQI 332

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1120 NTIEetGILAERARSRVESTEQLIEIASRELEKAKMAAANVSITQPESTGEpnnMTLLAEEARRLAERHKQEADDiVRVA 1199
Cdd:COG4913   333 RGNG--GDRLEQLEREIERLERELEERERRRARLEALLAALGLPLPASAEE---FAALRAEAAALLEALEEELEA-LEEA 406

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1200 KTANETSAEAYNLLLRTLAGEnqtaleIEELNRkyeQAKNISQDLekQAARvHEEAKRAGDKAVEIyasvaqltPVDSEA 1279
Cdd:COG4913   407 LAEAEAALRDLRRELRELEAE------IASLER---RKSNIPARL--LALR-DALAEALGLDEAEL--------PFVGEL 466

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1280 LEseankIKKEAAD-------------LDRLIDQKlkDYEDLR---EDMRGKEHEVKNLLEKGKAEQQTADqllaradaa 1343
Cdd:COG4913   467 IE-----VRPEEERwrgaiervlggfaLTLLVPPE--HYAAALrwvNRLHLRGRLVYERVRTGLPDPERPR--------- 530

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1344 kalaeeaakKGRNTL------------QEANDILNN------------LKDFDRRVN------DNKTAAE----EALRRI 1389
Cdd:COG4913   531 ---------LDPDSLagkldfkphpfrAWLEAELGRrfdyvcvdspeeLRRHPRAITragqvkGNGTRHEkddrRRIRSR 601

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1390 PAI---NRT-IAEANEKTREAQLALGNAAADATEAKNkaheaeriasgvQKNATSTKADAERTFSEVTDLDNEVNGMLRQ 1465
Cdd:COG4913   602 YVLgfdNRAkLAALEAELAELEEELAEAEERLEALEA------------ELDALQERREALQRLAEYSWDEIDVASAERE 669

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1466 LEEAENELKRkQDDADQDMmmagmasqaaQEAELNARKAKNSVSSLLSQLTDLLEQLGQLDtvdlNKLNEIEGSLNKAKD 1545
Cdd:COG4913   670 IAELEAELER-LDASSDDL----------AALEEQLEELEAELEELEEELDELKGEIGRLE----KELEQAEEELDELQD 734

                         570       580       590
                  ....*....|....*....|....*....|....*....
gi 281371490 1546 EM-KVSDLDRKVSNLENEARKQEAAILDYDRDIAEIIKD 1583
Cdd:COG4913   735 RLeAAEDLARLELRALLEERFAAALGDAVERELRENLEE 773
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 1047-1326 1.52e-05

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 49.79  E-value: 1.52e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1047 LQELESLIANLGTGDETVTDQafedrLKEAEREVTDLLREAQEVKdvdqnlMDRLQRVNNSLHSQiSRLHNIRNTI---E 1123
Cdd:pfam01576  779 LKELEAQIDAANKGREEAVKQ-----LKKLQAQMKDLQRELEEAR------ASRDEILAQSKESE-KKLKNLEAELlqlQ 846

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1124 ETGILAERARSRV--ESTEQLIEIASRELEKAKMA------AANVSITQPESTGEPNNMTLLAEEARRLAerhkQEADDI 1195
Cdd:pfam01576  847 EDLAASERARRQAqqERDELADEIASGASGKSALQdekrrlEARIAQLEEELEEEQSNTELLNDRLRKST----LQVEQL 922

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1196 vrvaktANETSAEaynlllRTLAGENQTALEieELNRKYEQAKNISQDLEKQAARVHeeakRAGDKAVEiyASVAQLtpv 1275
Cdd:pfam01576  923 ------TTELAAE------RSTSQKSESARQ--QLERQNKELKAKLQEMEGTVKSKF----KSSIAALE--AKIAQL--- 979

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 281371490  1276 dSEALESEAnKIKKEAADLDRLIDQKLKDYEDLREDMRGKEHEVKNLLEKG 1326
Cdd:pfam01576  980 -EEQLEQES-RERQAANKLVRRTEKKLKEVLLQVEDERRHADQYKDQAEKG 1028
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1359-1592 1.53e-05

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 49.13  E-value: 1.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1359 QEANDILNNLKDFDRRVNDNKTAAEEALRRIPAINRTIAEANEKTREAQLALGNAAADATEAKNKAHEAERIASGVQKNA 1438
Cdd:COG4372    45 EELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKER 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1439 TSTKADAERTFSEVTDLDNEVNGMLRQLEEAENELKRKQddadqdmmmAGMASQAAQEAELNARKAKNSVSSLLSQltdL 1518
Cdd:COG4372   125 QDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQ---------EELAALEQELQALSEAEAEQALDELLKE---A 192

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 281371490 1519 LEQLGQLDTVDLNKLNEIEGSLNKAKDEMKVSDLDRKVSNLENEARKQEAAILDYDRDIAEIIKDIHNLEDIKK 1592
Cdd:COG4372   193 NRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVILKEIEELELA 266
PTZ00440 PTZ00440
reticulocyte binding protein 2-like protein; Provisional
 1034-1594 1.78e-05

reticulocyte binding protein 2-like protein; Provisional


Pssm-ID: 240419 [Multi-domain]  Cd Length: 2722  Bit Score: 49.83  E-value: 1.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1034 RLVKDKVAEHRVKlQELESLIANLgtgdeTVTDQAFEDRLKEAEREVTDLLReaQEVKDVDQNLMDRLQRVNNSLHSQIS 1113
Cdd:PTZ00440  985 KLDKEKDEWEHFK-SEIDKLNVNY-----NILNKKIDDLIKKQHDDIIELID--KLIKEKGKEIEEKVDQYISLLEKMKT 1056

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1114 RLHNIRNTIEETGILAERARSRVESTEQLIEIASRELEKAKMAAANVSITQPEstgepnNMTLLAEEARRLAERHKQEAD 1193
Cdd:PTZ00440 1057 KLSSFHFNIDIKKYKNPKIKEEIKLLEEKVEALLKKIDENKNKLIEIKNKSHE------HVVNADKEKNKQTEHYNKKKK 1130

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1194 DIVRVAKTANETSAEaynllLRTLAGENQTALEIEELNRKYEQAKnISQDLEKqaarVHEEAKRAGDKAVEIYASVAQLT 1273
Cdd:PTZ00440 1131 SLEKIYKQMEKTLKE-----LENMNLEDITLNEVNEIEIEYERIL-IDHIVEQ----INNEAKKSKTIMEEIESYKKDID 1200

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1274 PVDsealeseANKIKKEAADLDRLidqklkDYEDLREDMRGKEHEVKNLLEKGKAEQQTADQLLARADAAKALAEEAAKK 1353
Cdd:PTZ00440 1201 QVK-------KNMSKERNDHLTTF------EYNAYYDKATASYENIEELTTEAKGLKGEANRSTNVDELKEIKLQVFSYL 1267

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1354 GR-----NTLQEANDILNNLKDFDRRVNDNKTAAEealrripaINRTIAEANEKTREAQLALGNAAADATEAKNKAHEAE 1428
Cdd:PTZ00440 1268 QQvikenNKMENALHEIKNMYEFLISIDSEKILKE--------ILNSTKKAEEFSNDAKKELEKTDNLIKQVEAKIEQAK 1339

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1429 RiasgvQKNATSTKADAERtfsevtdLDNEVNgMLRQLEEaenELKRKQDDadqdMMMAGMASQAAQE-AELNARKAKNS 1507
Cdd:PTZ00440 1340 E-----HKNKIYGSLEDKQ-------IDDEIK-KIEQIKE---EISNKRKE----INKYLSNIKSNKEkCDLHVRNASRG 1399

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1508 VSsllsqLTDLLEQLGQLDTVDLNKLN--EIEGSLNKAKDEMKvsdldrKVSNLENEARKQEAAILDYDRDIAEIIKDIH 1585
Cdd:PTZ00440 1400 KD-----KIDFLNKHEAIEPSNSKEVNiiKITDNINKCKQYSN------EAMETENKADENNDSIIKYEKEITNILNNSS 1468


                  ....*....
gi 281371490 1586 NLEdIKKTL 1594
Cdd:PTZ00440 1469 ILG-KKTKL 1476
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
 1042-1323 2.33e-05

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 49.19  E-value: 2.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1042 EHRVKLQELESLIANLgtgdetvtdQAFEDRLKEAEREVTDLLREaqevkDVDQN--LMDRLQRVNNSLHSQISRLH-NI 1118
Cdd:COG5185   233 EALKGFQDPESELEDL---------AQTSDKLEKLVEQNTDLRLE-----KLGENaeSSKRLNENANNLIKQFENTKeKI 298

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1119 RNTIEETGILAE---------RARSRVESTEQLIEIASRELE-KAKMAAANVSITQPESTGEPNNMTLLAEEARRLAERH 1188
Cdd:COG5185   299 AEYTKSIDIKKAtesleeqlaAAEAEQELEESKRETETGIQNlTAEIEQGQESLTENLEAIKEEIENIVGEVELSKSSEE 378

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1189 KQEADDIVRVAKTANE----TSAEAYNLLLRTLA---GENQTALE-----IEELNRKYEQAKNISQDLEKQAARVHEEAK 1256
Cdd:COG5185   379 LDSFKDTIESTKESLDeipqNQRGYAQEILATLEdtlKAADRQIEelqrqIEQATSSNEEVSKLLNELISELNKVMREAD 458

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 281371490 1257 RAGDKAVEIYASVAQLTpvdseaLESEANKIKKEAADLDRLIDQKLKDYEDLREDMRGKEHEVKNLL 1323
Cdd:COG5185   459 EESQSRLEEAYDEINRS------VRSKKEDLNEELTQIESRVSTLKATLEKLRAKLERQLEGVRSKL 519
mukB PRK04863
chromosome partition protein MukB;
1070-1534 2.61e-05

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 49.19  E-value: 2.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1070 EDRLKEAEREVTDLLREAQEVKDVDQNLMDRLQRVNNSLHSQisrlhnirNTIeetgilaERARSRVEsteqliEIASRe 1149
Cdd:PRK04863  306 QYRLVEMARELAELNEAESDLEQDYQAASDHLNLVQTALRQQ--------EKI-------ERYQADLE------ELEER- 363

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1150 LEKAKMAAAnvsitqpESTGEpnnmtllAEEARRLAERHKQEADDI------VRVAKTANETSAEAYN----LL--LRTL 1217
Cdd:PRK04863  364 LEEQNEVVE-------EADEQ-------QEENEARAEAAEEEVDELksqladYQQALDVQQTRAIQYQqavqALerAKQL 429

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1218 AGENQTALE-----IEELNRKYEQAKNISQDLEkQAARVHEEAKRAGDKAveiYASVAQLT-PVDsealESEANKIKKEA 1291
Cdd:PRK04863  430 CGLPDLTADnaedwLEEFQAKEQEATEELLSLE-QKLSVAQAAHSQFEQA---YQLVRKIAgEVS----RSEAWDVAREL 501

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1292 adLDRLIDQKLKDyeDLREDMRGKEHEvknlLEKGKAEQQTADQLlaradaakalaeeaakkgrntlqeandilnnLKDF 1371
Cdd:PRK04863  502 --LRRLREQRHLA--EQLQQLRMRLSE----LEQRLRQQQRAERL-------------------------------LAEF 542

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1372 DRRVNDNKTAAEEAlrripaiNRTIAEANEKTREAQLALGNAAADATEAKnkaHEAERIASGVQKNAtsTKADAERTFSE 1451
Cdd:PRK04863  543 CKRLGKNLDDEDEL-------EQLQEELEARLESLSESVSEARERRMALR---QQLEQLQARIQRLA--ARAPAWLAAQD 610

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1452 vtdldnevngMLRQLEEAENElkrkqDDADQDMMMAGMASQAAQEAELnaRKAKNSVSSLLSQLTDLLEQLGQLDTVDLN 1531
Cdd:PRK04863  611 ----------ALARLREQSGE-----EFEDSQDVTEYMQQLLEREREL--TVERDELAARKQALDEEIERLSQPGGSEDP 673


                  ...
gi 281371490 1532 KLN 1534
Cdd:PRK04863  674 RLN 676
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
 1172-1584 3.50e-05

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 48.42  E-value: 3.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1172 NNMTLLAEEARRLAERHKQEADDIVRVAKTaNETSAEAYNLLLRTlaGENQTaLEIEELNRKYEQAKNISQDLEKQAARv 1251
Cdd:COG5185   110 PNYEWSADILISLLYLYKSEIVALKDELIK-VEKLDEIADIEASY--GEVET-GIIKDIFGKLTQELNQNLKKLEIFGL- 184

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1252 hEEAKRAGDKAVEIYASVAQLT-PVDSEALESEANKIKKEAAD---LDRLIDQKLKDYEDLREDMRGKEHEVKNLLEKgK 1327
Cdd:COG5185   185 -TLGLLKGISELKKAEPSGTVNsIKESETGNLGSESTLLEKAKeiiNIEEALKGFQDPESELEDLAQTSDKLEKLVEQ-N 262

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1328 AEQQTADqllaradaakalaeeaAKKGRNTLQEANDILNNLKDFDRRVND---NKTAAEEALRRIPAINRTIAEANEktr 1404
Cdd:COG5185   263 TDLRLEK----------------LGENAESSKRLNENANNLIKQFENTKEkiaEYTKSIDIKKATESLEEQLAAAEA--- 323

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1405 EAQLALGNAAADaTEAKNKAHEAERIASGVQKNATSTKADAERTFSEVTDLDNEvngmlRQLEEAENELKRKQDDADQDM 1484
Cdd:COG5185   324 EQELEESKRETE-TGIQNLTAEIEQGQESLTENLEAIKEEIENIVGEVELSKSS-----EELDSFKDTIESTKESLDEIP 397

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1485 MMAgmaSQAAQEAELNARKAKNSVSSLLSQLTDLLEQLGQLDTVDLNKLNEIEGSLNKAKDEMKvsdlDRKVSNLENEAR 1564
Cdd:COG5185   398 QNQ---RGYAQEILATLEDTLKAADRQIEELQRQIEQATSSNEEVSKLLNELISELNKVMREAD----EESQSRLEEAYD 470

                         410       420
                  ....*....|....*....|
gi 281371490 1565 KQEAAILDYDRDIAEIIKDI 1584
Cdd:COG5185   471 EINRSVRSKKEDLNEELTQI 490
ATP-synt_B pfam00430
ATP synthase B/B' CF(0); Part of the CF(0) (base unit) of the ATP synthase. The base unit is ...
 1391-1503 5.45e-05

ATP synthase B/B' CF(0); Part of the CF(0) (base unit) of the ATP synthase. The base unit is thought to translocate protons through membrane (inner membrane in mitochondria, thylakoid membrane in plants, cytoplasmic membrane in bacteria). The B subunits are thought to interact with the stalk of the CF(1) subunits. This domain should not be confused with the ab CF(1) proteins (in the head of the ATP synthase) which are found in pfam00006


Pssm-ID: 425677 [Multi-domain]  Cd Length: 132  Bit Score: 44.61  E-value: 5.45e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1391 AINRTIAEANEKTREAQLALgnaaADATEAKNKAH-EAERIASGVQKNATSTKADAertfseVTDLDNEVNgmlRQLEEA 1469
Cdd:pfam00430   34 LIADEIAEAEERRKDAAAAL----AEAEQQLKEARaEAQEIIENAKKRAEKLKEEI------VAAAEAEAE---RIIEQA 100

                           90       100       110
                   ....*....|....*....|....*....|....
gi 281371490  1470 ENELKRKQDDAdqdmmMAGMASQAAQEAELNARK 1503
Cdd:pfam00430  101 AAEIEQEKDRA-----LAELRQQVVALAVQIAEK 129
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
826-870 7.02e-05

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 41.53  E-value: 7.02e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 281371490    826 CQCNDniDPNAVGNCNRLTGECLkCIYNTAGFYCDRCKEGFFGNP 870
Cdd:smart00180    1 CDCDP--GGSASGTCDPDTGQCE-CKPNVTGRRCDRCAPGYYGDG 42
PTZ00121 PTZ00121
MAEBL; Provisional
 1228-1569 7.05e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 47.83  E-value: 7.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1228 EELNRKYEQAKNI----------SQDLEKQA--------------ARVHEEAKRA-GDKAVEIYASVAQLTPVDSEALES 1282
Cdd:PTZ00121 1094 EEAFGKAEEAKKTetgkaeearkAEEAKKKAedarkaeearkaedARKAEEARKAeDAKRVEIARKAEDARKAEEARKAE 1173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1283 EANKIK--------KEAADLDRLID----QKLKDYEDLR--EDMRGKEHEvKNLLEKGKAEQQTADQLLARADAAKALAE 1348
Cdd:PTZ00121 1174 DAKKAEaarkaeevRKAEELRKAEDarkaEAARKAEEERkaEEARKAEDA-KKAEAVKKAEEAKKDAEEAKKAEEERNNE 1252

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1349 EAAKKGRNTLQEANDILNNLKDFDRRVNDNKTAAEEALR----RIPAINRTIAEANEKTREAQLAlGNAAADATEAKNKA 1424
Cdd:PTZ00121 1253 EIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKadeaKKAEEKKKADEAKKKAEEAKKA-DEAKKKAEEAKKKA 1331

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1425 HEAERIASGVQKNATSTKADAERTFSEVTDLDNEVNGMLRQLEEAenelKRKQDDADQDMMMAGMASQAAQEAELNARKA 1504
Cdd:PTZ00121 1332 DAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEA----KKKADAAKKKAEEKKKADEAKKKAEEDKKKA 1407

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 281371490 1505 -----KNSVSSLLSQLTDLLEQLGQLDtvDLNKLNEiegSLNKAKDEMKVSDLDRKVSNLEN---EARKQEAA 1569
Cdd:PTZ00121 1408 delkkAAAAKKKADEAKKKAEEKKKAD--EAKKKAE---EAKKADEAKKKAEEAKKAEEAKKkaeEAKKADEA 1475
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1212-1593 7.37e-05

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 46.82  E-value: 7.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1212 LLLRTLAGENQTAL-EIEELNRKYEQAKNISQDLEKQAARVHEEAKRAGDkavEIYASVAQLtpvdsEALESEANKIKKE 1290
Cdd:COG4372    24 ILIAALSEQLRKALfELDKLQEELEQLREELEQAREELEQLEEELEQARS---ELEQLEEEL-----EELNEQLQAAQAE 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1291 AADLDrlidQKLKDYEDLREDMRGKehevknlLEKGKAEQQTADQLlaradaakalaeeaakkgRNTLQEANDILNN-LK 1369
Cdd:COG4372    96 LAQAQ----EELESLQEEAEELQEE-------LEELQKERQDLEQQ------------------RKQLEAQIAELQSeIA 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1370 DFDRRVNDNKTAAEEALRRIPAINRTIAEANEKTREAQLalgnaaADATEAKNKAHEAERIASGVQKNATSTKADAERTF 1449
Cdd:COG4372   147 EREEELKELEEQLESLQEELAALEQELQALSEAEAEQAL------DELLKEANRNAEKEEELAEAEKLIESLPRELAEEL 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1450 SEVTDLDNEVNGmlRQLEEAENELKRKQDDADQDMMMAGMASQAAQEAELNARKAKNSVSSLLSQLTDLLEQLGQLDTVD 1529
Cdd:COG4372   221 LEAKDSLEAKLG--LALSALLDALELEEDKEELLEEVILKEIEELELAILVEKDTEEEELEIAALELEALEEAALELKLL 298

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 281371490 1530 LNKLNEIEGSLNKAKDEMKVSDLDRKVSNLENEARKQEAAILDYDRDIAEIIKDIHNLEDIKKT 1593
Cdd:COG4372   299 ALLLNLAALSLIGALEDALLAALLELAKKLELALAILLAELADLLQLLLVGLLDNDVLELLSKG 362
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1355-1569 7.75e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 47.07  E-value: 7.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1355 RNTLQEANDILNNLKDFDRRVNDNKTAAEEALRRIPAINRTIAEANEKTREAQLALgnaaadateAKNKAHEAERIASgV 1434
Cdd:COG4942    44 AALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAEL---------EAQKEELAELLRA-L 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1435 QKNATSTK----------ADAERTFSEVTDLDNEVNGMLRQLEEAENELKRKQDDADQDmmmagMASQAAQEAELNARKA 1504
Cdd:COG4942   114 YRLGRQPPlalllspedfLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAE-----RAELEALLAELEEERA 188

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 281371490 1505 KnsVSSLLSQLTDLLEQLGQldtvdlnKLNEIEGSLNKAKDEMKvsDLDRKVSNLENEARKQEAA 1569
Cdd:COG4942   189 A--LEALKAERQKLLARLEK-------ELAELAAELAELQQEAE--ELEALIARLEAEAAAAAER 242
Laminin_I pfam06008
Laminin Domain I; coiled-coil structure. It has been suggested that the domains I and II from ...
 1356-1537 7.83e-05

Laminin Domain I; coiled-coil structure. It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure.


Pssm-ID: 310534 [Multi-domain]  Cd Length: 258  Bit Score: 46.25  E-value: 7.83e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1356 NTLQE-ANDILNNLKDFDRRVNDNKTAAEEALRRIPAINRTIAEANEKTreAQLALGNAAADATEAKNKAHEAERIA--- 1431
Cdd:pfam06008   57 EELQKkATQTLAKAQQVNAESERTLGHAKELAEAIKNLIDNIKEINEKV--ATLGENDFALPSSDLSRMLAEAQRMLgei 134

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1432 -----SGVQKNATSTKADAERTFSEVTDL----DNEVNGMLRQLEEAENELKRKQDDADQDMMMAGMASQAAQeaELNAR 1502
Cdd:pfam06008  135 rsrdfGTQLQNAEAELKAAQDLLSRIQTWfqspQEENKALANALRDSLAEYEAKLSDLRELLREAAAKTRDAN--RLNLA 212

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 281371490  1503 KAKN---------SVSSLLSQLTDLLEQLGQ-LDTVDLnKLNEIE 1537
Cdd:pfam06008  213 NQANlrefqrkkeEVSEQKNQLEETLKTARDsLDAANL-LLQEID 256
growth_prot_Scy NF041483
polarized growth protein Scy;
1071-1565 7.84e-05

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 47.51  E-value: 7.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1071 DRLK-EAEREvtdlLREAQ-EVKDVDQNLMDRLQRVNNSLHSQ-ISR-------LHNIRNTIE----ETGILAERARSRV 1136
Cdd:NF041483   86 DQLRaDAERE----LRDARaQTQRILQEHAEHQARLQAELHTEaVQRrqqldqeLAERRQTVEshvnENVAWAEQLRART 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1137 ES-TEQLIEIASRELEKAkMAAANVsitqpestgepnnmtllaeEARRLAERHKQeaddivRVAKTANETSAEAYNLLLR 1215
Cdd:NF041483  162 ESqARRLLDESRAEAEQA-LAAARA-------------------EAERLAEEARQ------RLGSEAESARAEAEAILRR 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1216 TLAGENQTaleieeLNRKYEQAknisqdlekQAARVHEEAKRAgdkaveiyasvaqltpvdSEALESEAnkIKKEAADLD 1295
Cdd:NF041483  216 ARKDAERL------LNAASTQA---------QEATDHAEQLRS------------------STAAESDQ--ARRQAAELS 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1296 RLIDQKLKDYEdlrEDMRGKEHEVKNLLEKGK--AEQQTAdqllaradaakalaeeaakkgrnTLQEANDilnnlkdfdr 1373
Cdd:NF041483  261 RAAEQRMQEAE---EALREARAEAEKVVAEAKeaAAKQLA-----------------------SAESANE---------- 304

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1374 rvNDNKTAAEEalrripaINRTIAEAN---EKTR-EAQLALGNAAADATEAKNKAHEAERIASGvqKNATSTKADAERTf 1449
Cdd:NF041483  305 --QRTRTAKEE-------IARLVGEATkeaEALKaEAEQALADARAEAEKLVAEAAEKARTVAA--EDTAAQLAKAART- 372

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1450 sevtdldnevngmlrqleeAENELKRKQDDADQdmmmagMASQAAQEAELNARKAKNSVSSLLSQLTDLLEQLgqldtvd 1529
Cdd:NF041483  373 -------------------AEEVLTKASEDAKA------TTRAAAEEAERIRREAEAEADRLRGEAADQAEQL------- 420

                         490       500       510
                  ....*....|....*....|....*....|....*.
gi 281371490 1530 lnklneiEGSlnkAKDEMKvsDLDRKVSNLENEARK 1565
Cdd:NF041483  421 -------KGA---AKDDTK--EYRAKTVELQEEARR 444
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1257-1592 1.01e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 46.43  E-value: 1.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1257 RAGDKAVEIYASVAQLTPVDSEALESEANKIKKEAADLDRLidqkLKDYEDLREDMRGKEHEVKNL---LEKGKAEQQTA 1333
Cdd:COG4372     3 RLGEKVGKARLSLFGLRPKTGILIAALSEQLRKALFELDKL----QEELEQLREELEQAREELEQLeeeLEQARSELEQL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1334 DQLlaradaakalaeeaakkgrntLQEANDILNNLKDFDRRVNDNKTAAEEALRRIPA-INRTIAEANEKTREAQLALGN 1412
Cdd:COG4372    79 EEE---------------------LEELNEQLQAAQAELAQAQEELESLQEEAEELQEeLEELQKERQDLEQQRKQLEAQ 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1413 AAADATEAKNKAHEAERIASGVQKNATSTKA-DAERTFSEVTDLDNEVNGMLRQLEeaENELKRKQDDADQDMMMAGMAS 1491
Cdd:COG4372   138 IAELQSEIAEREEELKELEEQLESLQEELAAlEQELQALSEAEAEQALDELLKEAN--RNAEKEEELAEAEKLIESLPRE 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1492 QAAQEAELNARKAKNSVSSLLSQLTDLLEQLGQLDTVDLNKLNEIEGSLNKAKDE-----MKVSDLDRKVSNLENEARKQ 1566
Cdd:COG4372   216 LAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVILKEIEELELAILVEkdteeEELEIAALELEALEEAALEL 295

                         330       340
                  ....*....|....*....|....*.
gi 281371490 1567 EAAILDYDRDIAEIIKDIHNLEDIKK 1592
Cdd:COG4372   296 KLLALLLNLAALSLIGALEDALLAAL 321
mukB PRK04863
chromosome partition protein MukB;
1382-1594 1.20e-04

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 46.87  E-value: 1.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1382 AEEALRRIPAINRTIA---EANEKTREAQLALGNAAADATEAKNKAHEAE----RIASG---VQK--NATSTKA------ 1443
Cdd:PRK04863  340 VQTALRQQEKIERYQAdleELEERLEEQNEVVEEADEQQEENEARAEAAEeevdELKSQladYQQalDVQQTRAiqyqqa 419

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1444 ----DAERTFSEVTDLDNE-VNGMLRQLEEAENELKRKQDDADQDMMMAGMA-SQAAQEAELnARK---------AKNSV 1508
Cdd:PRK04863  420 vqalERAKQLCGLPDLTADnAEDWLEEFQAKEQEATEELLSLEQKLSVAQAAhSQFEQAYQL-VRKiagevsrseAWDVA 498

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1509 SSLLSQLTD---LLEQLGQLDtvdlNKLNEIEGSLNK-------AKDEMKVSDLD-RKVSNLENEARKQEAAILDYDRDI 1577
Cdd:PRK04863  499 RELLRRLREqrhLAEQLQQLR----MRLSELEQRLRQqqraerlLAEFCKRLGKNlDDEDELEQLQEELEARLESLSESV 574

                         250
                  ....*....|....*..
gi 281371490 1578 AEIIKDIHNLEDIKKTL 1594
Cdd:PRK04863  575 SEARERRMALRQQLEQL 591
Laminin_I pfam06008
Laminin Domain I; coiled-coil structure. It has been suggested that the domains I and II from ...
 1106-1370 1.24e-04

Laminin Domain I; coiled-coil structure. It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure.


Pssm-ID: 310534 [Multi-domain]  Cd Length: 258  Bit Score: 45.48  E-value: 1.24e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1106 NSLHSQISRLHNIRNTIEETGILAERARSRVESTEQLIEIASRELEKAKMAAANVsitQPESTGEPNNMTLLAEEARRLA 1185
Cdd:pfam06008    5 NSLTGALPAPYKINYNLENLTKQLQEYLSPENAHKIQIEILEKELSSLAQETEEL---QKKATQTLAKAQQVNAESERTL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1186 ERHKQEADDIVRVAKTANETSAEAYNLllrtlaGENQTALEIEELNRKYEQAKNI-----SQDLEKQaarvHEEAKRAGD 1260
Cdd:pfam06008   82 GHAKELAEAIKNLIDNIKEINEKVATL------GENDFALPSSDLSRMLAEAQRMlgeirSRDFGTQ----LQNAEAELK 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1261 KAVEIYASVAQLTPVDSEALESEANKIKKEAADLDrlidQKLKDYEDLREDMRGKEHEVKNLLEKGKAEQQTADQLLARA 1340
Cdd:pfam06008  152 AAQDLLSRIQTWFQSPQEENKALANALRDSLAEYE----AKLSDLRELLREAAAKTRDANRLNLANQANLREFQRKKEEV 227

                          250       260       270
                   ....*....|....*....|....*....|
gi 281371490  1341 DAAKALAEEAAKKGRNTLQEANDILNNLKD 1370
Cdd:pfam06008  228 SEQKNQLEETLKTARDSLDAANLLLQEIDD 257
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 340-394 1.31e-04

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 41.18  E-value: 1.31e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 281371490   340 CDCNGR---SQECYFdpelyrstgHGGHCTnCRDNTDGAKCERCRENFFRLGNTEACS 394
Cdd:pfam00053    1 CDCNPHgslSDTCDP---------ETGQCL-CKPGVTGRHCDRCKPGYYGLPSDPPQG 48
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
1226-1533 1.38e-04

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 45.67  E-value: 1.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1226 EIEELNRKYEQAKNISQDLEKQ------------------AARVHE---EAKRAGDKAVEIYASVAQLTPVDSEALEsEA 1284
Cdd:COG1340     9 SLEELEEKIEELREEIEELKEKrdelneelkelaekrdelNAQVKElreEAQELREKRDELNEKVKELKEERDELNE-KL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1285 NKIKKEAADLDRLIDQKLK---DYEDLREDMRGkehevknlLEKgkaEQQTADQllaradaakalaeeaakkgrnTLQEA 1361
Cdd:COG1340    88 NELREELDELRKELAELNKaggSIDKLRKEIER--------LEW---RQQTEVL---------------------SPEEE 135

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1362 NDILNNLKDFDRRVNDNKTAAEEalrripaiNRTIAEANEKTREAQLALGNAAADATEAKNKAHEA-ERIASGVQKnATS 1440
Cdd:COG1340   136 KELVEKIKELEKELEKAKKALEK--------NEKLKELRAELKELRKEAEEIHKKIKELAEEAQELhEEMIELYKE-ADE 206

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1441 TKADAERTFSEVTDLDNEVNgmlrQLEEAENELKRKQDDADQDMMMagmasqaAQEAELNARKAKNSvSSLLSQLTDLLE 1520
Cdd:COG1340   207 LRKEADELHKEIVEAQEKAD----ELHEEIIELQKELRELRKELKK-------LRKKQRALKREKEK-EELEEKAEEIFE 274

                         330
                  ....*....|....*.
gi 281371490 1521 QL---GQLDTVDLNKL 1533
Cdd:COG1340   275 KLkkgEKLTTEELKLL 290
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1413-1594 1.44e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 45.98  E-value: 1.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1413 AAADATEAKNKAHeAERIASGVQKNATSTKADAERTFSEVTDLDNEVNGMLRQLEEAENELKRKQDDADQdmmmaGMASQ 1492
Cdd:COG3883     1 ALALALAAPTPAF-ADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDK-----LQAEI 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1493 AAQEAELNARKAKnsvssLLSQLTDLLEQLGQLDTVDLnklneiegsLNKAKDemkVSDLDRKVSNLENEARKQEAAILD 1572
Cdd:COG3883    75 AEAEAEIEERREE-----LGERARALYRSGGSVSYLDV---------LLGSES---FSDFLDRLSALSKIADADADLLEE 137

                         170       180
                  ....*....|....*....|..
gi 281371490 1573 YDRDIAEIIKDIHNLEDIKKTL 1594
Cdd:COG3883   138 LKADKAELEAKKAELEAKLAEL 159
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 1267-1502 1.53e-04

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 45.99  E-value: 1.53e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1267 ASVAQLTPVDSEALESEANKIK---KEAADLDRLIDQKL-KDYEDLREDMRGKEHEVKNLLEKGKAEQQTADQllarada 1342
Cdd:TIGR02794   35 AEIIQAVLVDPGAVAQQANRIQqqkKPAAKKEQERQKKLeQQAEEAEKQRAAEQARQKELEQRAAAEKAAKQA------- 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1343 akalaeeaakkgrntlQEANdilnnlkdfdRRVNDNKTAAEEALRRIPAINRTIAEANEKTREAQLALGNAAADAT---- 1418
Cdd:TIGR02794  108 ----------------EQAA----------KQAEEKQKQAEEAKAKQAAEAKAKAEAEAERKAKEEAAKQAEEEAKakaa 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1419 -EAKNKAHEAERIASGVQKNATSTKADAERtfsEVTDLDNEvngmlRQLEEAENELKRKQdDADQDMMMAGMASQAAQEA 1497
Cdd:TIGR02794  162 aEAKKKAEEAKKKAEAEAKAKAEAEAKAKA---EEAKAKAE-----AAKAKAAAEAAAKA-EAEAAAAAAAEAERKADEA 232


                   ....*
gi 281371490  1498 ELNAR 1502
Cdd:TIGR02794  233 ELGDI 237
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 770-818 1.53e-04

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 40.80  E-value: 1.53e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 281371490  770 PCPCPGGSSCAIVPKTKEVVCtHCPTGTAGKRCELCDDGYFGDPLGSNG 818
Cdd:cd00055     1 PCDCNGHGSLSGQCDPGTGQC-ECKPNTTGRRCDRCAPGYYGLPSQGGG 48
MA smart00283
Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo ...
 1357-1522 2.04e-04

Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.


Pssm-ID: 214599 [Multi-domain]  Cd Length: 262  Bit Score: 44.97  E-value: 2.04e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490   1357 TLQEANDILNNLKDFDRRVNDNKTAAEEALRRIPAINRTIAEANEKTREAQ----------------------LALgNAA 1414
Cdd:smart00283   37 VAANADEIAATAQSAAEAAEEGREAVEDAITAMDQIREVVEEAVSAVEELEessdeigeivsviddiadqtnlLAL-NAA 115

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490   1415 ----------------AD-----ATEAKNKAHEAERIASGVQKNATSTKADAERTFSEV-----------------TDLD 1456
Cdd:smart00283  116 ieaarageagrgfavvADevrklAERSAESAKEIESLIKEIQEETNEAVAAMEESSSEVeegvelveetgdaleeiVDSV 195

                           170       180       190       200       210       220
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 281371490   1457 NEVNGMLRQLEEAENELKRKQDDADQDMM-MAGMASQAAQEAELNARKAKnSVSSLLSQLTDLLEQL 1522
Cdd:smart00283  196 EEIADLVQEIAAATDEQAAGSEEVNAAIDeIAQVTQETAAMSEEISAAAE-ELSGLAEELDELVERF 261
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1033-1246 2.21e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 46.20  E-value: 2.21e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1033 YRLVKDKVAEHRVKLQELESLIANLGTGDETVTDQA--FEDRLKEAEREVTDL---LREAQEVKDVDQNLMDRLQRvnnS 1107
Cdd:TIGR02168  812 LTLLNEEAANLRERLESLERRIAATERRLEDLEEQIeeLSEDIESLAAEIEELeelIEELESELEALLNERASLEE---A 888

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1108 LHSQISRLHNIRNTIEETGILAERARSRVESTEQLIEIASRELEKAKM--------AAANVSITQPESTGEPNNMTLLAE 1179
Cdd:TIGR02168  889 LALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVridnlqerLSEEYSLTLEEAEALENKIEDDEE 968

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 281371490  1180 EARRLAERHKQEADDIVRVaktaNETSAEaynlllrtlagenqtalEIEELNRKYEQAKNISQDLEK 1246
Cdd:TIGR02168  969 EARRRLKRLENKIKELGPV----NLAAIE-----------------EYEELKERYDFLTAQKEDLTE 1014
AtpF COG0711
FoF1-type ATP synthase, membrane subunit b or b' [Energy production and conversion]; FoF1-type ...
 1388-1515 2.22e-04

FoF1-type ATP synthase, membrane subunit b or b' [Energy production and conversion]; FoF1-type ATP synthase, membrane subunit b or b' is part of the Pathway/BioSystem: FoF1-type ATP synthase


Pssm-ID: 440475 [Multi-domain]  Cd Length: 152  Bit Score: 43.24  E-value: 2.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1388 RIPAINRTIAEANEKTREAQLALGNAAADATEAKnkaHEAERIASGVQKNATSTKADAertfseVTDLDNEVNgmlRQLE 1467
Cdd:COG0711    32 RQEKIADGLAEAERAKEEAEAALAEYEEKLAEAR---AEAAEIIAEARKEAEAIAEEA------KAEAEAEAE---RIIA 99

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 281371490 1468 EAENELKRKQDDADQDM--MMAGMASQAAQ---EAELNARKAKNSVSSLLSQL 1515
Cdd:COG0711   100 QAEAEIEQERAKALAELraEVADLAVAIAEkilGKELDAAAQAALVDRFIAEL 152
46 PHA02562
endonuclease subunit; Provisional
 1071-1304 2.42e-04

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 45.78  E-value: 2.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1071 DRLKEAEREVTDL---LREAQEVKDVDQNLMDRLQRVNNSlhsQISRLHNIrntIEETGILAERARSRVES-TEQLIEIA 1146
Cdd:PHA02562  174 DKIRELNQQIQTLdmkIDHIQQQIKTYNKNIEEQRKKNGE---NIARKQNK---YDELVEEAKTIKAEIEElTDELLNLV 247

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1147 ------SRELEKAKMAAANVS---------------------ITQPESTgEPNNMTLLAEEARRLAERHKQEADDIVRVA 1199
Cdd:PHA02562  248 mdiedpSAALNKLNTAAAKIKskieqfqkvikmyekggvcptCTQQISE-GPDRITKIKDKLKELQHSLEKLDTAIDELE 326

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1200 KTANEtsaeaYNLLLRTlagenqtaleIEELNRKYEQAKNISQDLEKQAARVHEEAKRAGDKAVEIYASVAQLTPvDSEA 1279
Cdd:PHA02562  327 EIMDE-----FNEQSKK----------LLELKNKISTNKQSLITLVDKAKKVKAAIEELQAEFVDNAEELAKLQD-ELDK 390

                         250       260
                  ....*....|....*....|....*
gi 281371490 1280 LESEANKIKKEAADLDrLIDQKLKD 1304
Cdd:PHA02562  391 IVKTKSELVKEKYHRG-IVTDLLKD 414
RecN COG0497
DNA repair ATPase RecN [Replication, recombination and repair];
1358-1583 2.65e-04

DNA repair ATPase RecN [Replication, recombination and repair];


Pssm-ID: 440263 [Multi-domain]  Cd Length: 555  Bit Score: 45.45  E-value: 2.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1358 LQEANDILNNLKDFDRRVNDNKTAAEEALRRIPAINRTIAE-------ANEktrEAQLA-----LGNAAadatEAKNKAH 1425
Cdd:COG0497   157 LEEYREAYRAWRALKKELEELRADEAERARELDLLRFQLEEleaaalqPGE---EEELEeerrrLSNAE----KLREALQ 229

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1426 EAERIASGVQKNATSTKADAERTFSEVTDLD---NEVNGMLR----QLEEAENELKRKQDDADQDmmmagmaSQAAQEAE 1498
Cdd:COG0497   230 EALEALSGGEGGALDLLGQALRALERLAEYDpslAELAERLEsaliELEEAASELRRYLDSLEFD-------PERLEEVE 302

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1499 --LN-----ARKAKNSVSSLLSQLTDLLEQLGQLDTVDlNKLNEIEGSLNKAKDEMkvSDLDRKVSnlenEARKQEAAIL 1571
Cdd:COG0497   303 erLAllrrlARKYGVTVEELLAYAEELRAELAELENSD-ERLEELEAELAEAEAEL--LEAAEKLS----AARKKAAKKL 375

                         250
                  ....*....|..
gi 281371490 1572 dyDRDIAEIIKD 1583
Cdd:COG0497   376 --EKAVTAELAD 385
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 1037-1259 2.75e-04

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 45.73  E-value: 2.75e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1037 KDKVAEHRVKLQELESLIANLgTGDETVTDQAFEdRLKEAEREVTDLLREAQEVKDVDQNLMDRLQRVNNSL-HSQISRL 1115
Cdd:TIGR00618  672 KELLASRQLALQKMQSEKEQL-TYWKEMLAQCQT-LLRELETHIEEYDREFNEIENASSSLGSDLAAREDALnQSLKELM 749

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1116 HNIRNTIEETGILAERARSRVESTEQLIEiasrELEKAKMAAANVSITQPESTGEpnnmtlLAEearrLAERHKQEADDI 1195
Cdd:TIGR00618  750 HQARTVLKARTEAHFNNNEEVTAALQTGA----ELSHLAAEIQFFNRLREEDTHL------LKT----LEAEIGQEIPSD 815

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 281371490  1196 VRVAKTANETSAEAYNLLLRTLAGENQTALEIEELNRKYEQAKNISQDLEKQAARVHEEAKRAG 1259
Cdd:TIGR00618  816 EDILNLQCETLVQEEEQFLSRLEEKSATLGEITHQLLKYEECSKQLAQLTQEQAKIIQLSDKLN 879
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 1065-1578 2.82e-04

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 45.58  E-value: 2.82e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1065 TDQAFEDRLKeAEREVTDLLREAQEVKDVD-------QNLMDRLQRVNNSLHS-QISRLHNIRNTIEETGILAERAR--- 1133
Cdd:pfam10174   75 TIQALQDELR-AQRDLNQLLQQDFTTSPVDgedkfstPELTEENFRRLQSEHErQAKELFLLRKTLEEMELRIETQKqtl 153

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1134 -SRVESTEQLIEI------ASRELE-----KAKMAAANVSITQPES---TGEPNNMTLLAEEARR---LAERHKQEADDI 1195
Cdd:pfam10174  154 gARDESIKKLLEMlqskglPKKSGEedwerTRRIAEAEMQLGHLEVlldQKEKENIHLREELHRRnqlQPDPAKTKALQT 233

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1196 VRVAKTANETSAEAYNlllRTLAGENQT-----ALEIEE-----------------LNRKYEQAKnisQDLEKQAA---- 1249
Cdd:pfam10174  234 VIEMKDTKISSLERNI---RDLEDEVQMlktngLLHTEDreeeikqmevykshskfMKNKIDQLK---QELSKKESella 307

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1250 ---------------RVHEEAKRAGDKAVEIYASVAQlTPVDS--EALESEANKIKKEAADLDRLIDQK---------LK 1303
Cdd:pfam10174  308 lqtkletltnqnsdcKQHIEVLKESLTAKEQRAAILQ-TEVDAlrLRLEEKESFLNKKTKQLQDLTEEKstlageirdLK 386

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1304 DY---------------EDLREDMRGKEHEVKNLLEKGKAEQQ---TADQLLAradaakalaeeaakkgrnTLQEA---- 1361
Cdd:pfam10174  387 DMldvkerkinvlqkkiENLQEQLRDKDKQLAGLKERVKSLQTdssNTDTALT------------------TLEEAlsek 448

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1362 NDILNNLK---DFDRR-----VNDNKTAAEEALRRIPAINRTIAEANE-----KTREAQLALGNAAADAT------EAKN 1422
Cdd:pfam10174  449 ERIIERLKeqrEREDRerleeLESLKKENKDLKEKVSALQPELTEKESslidlKEHASSLASSGLKKDSKlksleiAVEQ 528

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1423 KAHEAERIASGVQKnaTSTKADAERTFSEVTD----LDNEVNG--------------MLRQLEEAENE--LKRKQDDADQ 1482
Cdd:pfam10174  529 KKEECSKLENQLKK--AHNAEEAVRTNPEINDrirlLEQEVARykeesgkaqaeverLLGILREVENEknDKDKKIAELE 606

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1483 DMMMAGMASQAAQEAELNA----RKAKNsvsslLSQLTD-LLEQLGQLDTVDLNKLNEIEGSLNKAK---DEMK------ 1548
Cdd:pfam10174  607 SLTLRQMKEQNKKVANIKHgqqeMKKKG-----AQLLEEaRRREDNLADNSQQLQLEELMGALEKTRqelDATKarlsst 681

                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....*
gi 281371490  1549 ---VSDLDRKVSNLENEARKQ-E-----------AAILDYDRDIA 1578
Cdd:pfam10174  682 qqsLAEKDGHLTNLRAERRKQlEeilemkqeallAAISEKDANIA 726
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 1037-1591 2.88e-04

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 45.81  E-value: 2.88e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1037 KDKVAEHRVKLQELESLIANlgtgdeTVTDqafeDRLKEAEREVTD---LLREAQEVKDVDQNLMDRLQRVN------NS 1107
Cdd:TIGR01612  859 KEKIDSEHEQFAELTNKIKA------EISD----DKLNDYEKKFNDsksLINEINKSIEEEYQNINTLKKVDeyikicEN 928

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1108 LHSQISRLHNIRN-----------TIEETGILAERARSRVEST----EQLIEIASRELEKAKMAAANVSITQ-----PES 1167
Cdd:TIGR01612  929 TKESIEKFHNKQNilkeilnknidTIKESNLIEKSYKDKFDNTlidkINELDKAFKDASLNDYEAKNNELIKyfndlKAN 1008

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1168 TGEPNNMTLLaeeaRRLAERHKQeADDIVRVAKTANET--------SAEAYNLLLRTlagENQTALEIEELNrkyeqaKN 1239
Cdd:TIGR01612 1009 LGKNKENMLY----HQFDEKEKA-TNDIEQKIEDANKNipnieiaiHTSIYNIIDEI---EKEIGKNIELLN------KE 1074

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1240 ISQDLEKQAARVHEEAKRAGDKAVEIYASVAQLTPVDsealesEANKIKKEAADLDRLIDQKLKDYEDLREDMRGKEHEV 1319
Cdd:TIGR01612 1075 ILEEAEINITNFNEIKEKLKHYNFDDFGKEENIKYAD------EINKIKDDIKNLDQKIDHHIKALEEIKKKSENYIDEI 1148

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1320 K---NLLEKgKAEQQTADQLLARADAAKALAEEAAKKGRNTLQEANDILNNLKDFDRrvndNKTAAEEalrrIPAINRT- 1395
Cdd:TIGR01612 1149 KaqiNDLED-VADKAISNDDPEEIEKKIENIVTKIDKKKNIYDEIKKLLNEIAEIEK----DKTSLEE----VKGINLSy 1219

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1396 -----------IAEANEKTREAQLALGNAAADATEAKNKAHEAER---IASGVQK--NATSTKADAERTFSEVTDLDNEV 1459
Cdd:TIGR01612 1220 gknlgklflekIDEEKKKSEHMIKAMEAYIEDLDEIKEKSPEIENemgIEMDIKAemETFNISHDDDKDHHIISKKHDEN 1299

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1460 NGMLRqleeaENELKRKQDDADQDMMmaGMASQAAQEAELNARKAKNSVSSLLSQLTDLLEQLgqldtvdlnKLNEIEGS 1539
Cdd:TIGR01612 1300 ISDIR-----EKSLKIIEDFSEESDI--NDIKKELQKNLLDAQKHNSDINLYLNEIANIYNIL---------KLNKIKKI 1363

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|..
gi 281371490  1540 LNKAKDEMKvsDLDRKVSNLENEARKQEAAIldydrdiaEIIKDIHNLEDIK 1591
Cdd:TIGR01612 1364 IDEVKEYTK--EIEENNKNIKDELDKSEKLI--------KKIKDDINLEECK 1405
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 284-325 3.27e-04

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 40.03  E-value: 3.27e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 281371490   284 CKCNGHASECVKNEFGKLVCNCKHNTYGVDCEKCLPFFNDRP 325
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLP 42
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 1227-1461 3.33e-04

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 44.80  E-value: 3.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1227 IEELNRKYEQAKNiSQDLEKQaaRVHEEAKRAGDKAVEIYASVAQLTPVDSEALEseANKIKKEAADLDRLIDQKLKdye 1306
Cdd:PRK09510   61 VEQYNRQQQQQKS-AKRAEEQ--RKKKEQQQAEELQQKQAAEQERLKQLEKERLA--AQEQKKQAEEAAKQAALKQK--- 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1307 dLREDMRGKEHEVKNLleKGKAEQQTADQLLARADAAKALAEEAAKKGRNTlQEANdilnnlkdfdrrvndnKTAAEEAL 1386
Cdd:PRK09510  133 -QAEEAAAKAAAAAKA--KAEAEAKRAAAAAKKAAAEAKKKAEAEAAKKAA-AEAK----------------KKAEAEAA 192

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 281371490 1387 RRIPAINRTIAEANEKTREAQLALGNAAADATEAKNKAhEAERIASGVQKNATSTKADAERTfSEVTDLDNEVNG 1461
Cdd:PRK09510  193 AKAAAEAKKKAEAEAKKKAAAEAKKKAAAEAKAAAAKA-AAEAKAAAEKAAAAKAAEKAAAA-KAAAEVDDLFGG 265
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1208-1432 3.57e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 45.29  E-value: 3.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1208 EAYNLLLRtlAGENQTALE-IEELNRKYEQAKNISQDLE--KQAARVHEEAKRAGDKAVEIyasvaqltpvdsEALESEA 1284
Cdd:COG4913   239 RAHEALED--AREQIELLEpIRELAERYAAARERLAELEylRAALRLWFAQRRLELLEAEL------------EELRAEL 304

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1285 NKIKKEAADLDRLIDQKLKDYEDLREDMRGKEHEVKNLLEKgkaEQQTADqllaradaakalaeeaakkgrntlQEANDI 1364
Cdd:COG4913   305 ARLEAELERLEARLDALREELDELEAQIRGNGGDRLEQLER---EIERLE------------------------RELEER 357

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 281371490 1365 LNNLKDFDRRVND-----NKTAAE-EALRRipAINRTIAEANEKTREAQLALGNAAADATEAKNKAHEAER-IAS 1432
Cdd:COG4913   358 ERRRARLEALLAAlglplPASAEEfAALRA--EAAALLEALEEELEALEEALAEAEAALRDLRRELRELEAeIAS 430
Taxilin pfam09728
Myosin-like coiled-coil protein; Taxilin contains an extraordinarily long coiled-coil domain ...
 1281-1594 4.19e-04

Myosin-like coiled-coil protein; Taxilin contains an extraordinarily long coiled-coil domain in its C-terminal half and is ubiquitously expressed. It is a novel binding partner of several syntaxin family members and is possibly involved in Ca2+-dependent exocytosis in neuroendocrine cells. Gamma-taxilin, described as leucine zipper protein Factor Inhibiting ATF4-mediated Transcription (FIAT), localizes to the nucleus in osteoblasts and dimerizes with ATF4 to form inactive dimers, thus inhibiting ATF4-mediated transcription.


Pssm-ID: 462861 [Multi-domain]  Cd Length: 302  Bit Score: 44.17  E-value: 4.19e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1281 ESEANKIKKEAADLDRLIDQKLKDYEDLREDMRGKEHEVKNLLEKGKAEQQTADQLLARadaakalaeeaakkgRNTLQE 1360
Cdd:pfam09728    3 ARELMQLLNKLDSPEEKLAALCKKYAELLEEMKRLQKDLKKLKKKQDQLQKEKDQLQSE---------------LSKAIL 67

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1361 ANDILNNL-KDFDRRvndNKTAAEEALRRIpainrtiAEANEKTREAQLALGNAAADATEaknkaheaeRIASGVQKNAT 1439
Cdd:pfam09728   68 AKSKLEKLcRELQKQ---NKKLKEESKKLA-------KEEEEKRKELSEKFQSTLKDIQD---------KMEEKSEKNNK 128

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1440 STKADAE-----RTFSEVTDL-DNEVNGMLRQ--LEEAENELKRKQDDADQDmmmagmasQAAQEAELN-ARKAKNSVSS 1510
Cdd:pfam09728  129 LREENEElreklKSLIEQYELrELHFEKLLKTkeLEVQLAEAKLQQATEEEE--------KKAQEKEVAkARELKAQVQT 200

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1511 LLSQLTDLLEQL-------GQL-DTvdLNKLNEIEGSLNKAKDEM--KVSDLDRkvsnlENEA--RKQEA---AILD--- 1572
Cdd:pfam09728  201 LSETEKELREQLnlyvekfEEFqDT--LNKSNEVFTTFKKEMEKMskKIKKLEK-----ENLTwkRKWEKsnkALLEmae 273

                          330       340
                   ....*....|....*....|....*.
gi 281371490  1573 ----YDRDIAEIIKDIHNLEDIKKTL 1594
Cdd:pfam09728  274 erqkLKEELEKLQKKLEKLENLCRAL 299
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 339-387 4.29e-04

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 39.64  E-value: 4.29e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 281371490  339 PCDCNGR---SQECYFdpelyrstgHGGHCTnCRDNTDGAKCERCRENFFRL 387
Cdd:cd00055     1 PCDCNGHgslSGQCDP---------GTGQCE-CKPNTTGRRCDRCAPGYYGL 42
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1128-1280 4.95e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 43.95  E-value: 4.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1128 LAERARSRVESTEQLIEI--ASRELEKA-----KMAAANvsitqpestgePNNMTLLAEEARRLAERHK-QEADDIVRVA 1199
Cdd:COG2956   102 LLELDPDDAEALRLLAEIyeQEGDWEKAievleRLLKLG-----------PENAHAYCELAELYLEQGDyDEAIEALEKA 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1200 KTANETSAEAYNLLLRTLAGENQTALEIEELNRKYEQAKNISQDLEKqAARVHEEAKRAgDKAVEIYASVAQLTPVDSEA 1279
Cdd:COG2956   171 LKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPR-LAELYEKLGDP-EEALELLRKALELDPSDDLL 248


                  .
gi 281371490 1280 L 1280
Cdd:COG2956   249 L 249
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 1044-1333 5.15e-04

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 44.73  E-value: 5.15e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1044 RVKLQELESLIANLgtgDETVTDQAFEDR--LKEAEREVTDLLREAQEVKDVDQNLMDRLQRV-------NNSLHSQISR 1114
Cdd:pfam05557    1 RAELIESKARLSQL---QNEKKQMELEHKraRIELEKKASALKRQLDRESDRNQELQKRIRLLekreaeaEEALREQAEL 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1115 LHNIRNTIEETGILAERARSRVESTEQLI-----EIAS--RELEKAKMAaanvsitqpestgepnnMTLLAEEARRLAER 1187
Cdd:pfam05557   78 NRLKKKYLEALNKKLNEKESQLADAREVIsclknELSElrRQIQRAELE-----------------LQSTNSELEELQER 140

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1188 HKQEAddivrvAKTAN-ETSAEAYNLLLRTLAGENQTALEIEELNRKYEQAKNISQDLEKQAARVHEEAKRagdkaveiy 1266
Cdd:pfam05557  141 LDLLK------AKASEaEQLRQNLEKQQSSLAEAEQRIKELEFEIQSQEQDSEIVKNSKSELARIPELEKE--------- 205

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 281371490  1267 asVAQLTPVDSEALESEANK--IKKEAADLDRlidqKLKDYEDLREDMRGKEHEVKNLLEKGKAEQQTA 1333
Cdd:pfam05557  206 --LERLREHNKHLNENIENKllLKEEVEDLKR----KLEREEKYREEAATLELEKEKLEQELQSWVKLA 268
mukB PRK04863
chromosome partition protein MukB;
1192-1526 5.29e-04

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 44.95  E-value: 5.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1192 ADDIVRVAKTANETSAEAYNL------LLRTLAGENQTAleiEELNRKYEQAKNISQDLEK--QAARVH----EEAKRAG 1259
Cdd:PRK04863  271 AADYMRHANERRVHLEEALELrrelytSRRQLAAEQYRL---VEMARELAELNEAESDLEQdyQAASDHlnlvQTALRQQ 347

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1260 DKAVEIYASVAQLTPVDSEALES--------EANKIKKEAADL--DRLIDQkLKDYE---DLREDMRGKEHEVKNLLEKG 1326
Cdd:PRK04863  348 EKIERYQADLEELEERLEEQNEVveeadeqqEENEARAEAAEEevDELKSQ-LADYQqalDVQQTRAIQYQQAVQALERA 426

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1327 KAEQQTADQLlaradaakalaeeaakkgrntlqeandiLNNLKDF-DRRVNDNKTAAEEALrripainrtiaEAnektrE 1405
Cdd:PRK04863  427 KQLCGLPDLT----------------------------ADNAEDWlEEFQAKEQEATEELL-----------SL-----E 462

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1406 AQLALGNAAADATEaknKAHEA-ERIASGVQKNATSTKA-DAERTFSEVTDLDNEVNGMLRQLEEAENELkRKQDDADQD 1483
Cdd:PRK04863  463 QKLSVAQAAHSQFE---QAYQLvRKIAGEVSRSEAWDVArELLRRLREQRHLAEQLQQLRMRLSELEQRL-RQQQRAERL 538

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 281371490 1484 MMMAGMAS-------------QAAQEAELNArkAKNSVSSLLSQLTDLLEQLGQLD 1526
Cdd:PRK04863  539 LAEFCKRLgknlddedeleqlQEELEARLES--LSESVSEARERRMALRQQLEQLQ 592
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1065-1256 6.01e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 44.62  E-value: 6.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1065 TDQAFEDRLKEAEREVTDLLREAQEVKdVDQNLMDrLQRVNNSLHSQISRLhniRNTIEETGILAERARSRVESTEQLIE 1144
Cdd:COG3206   176 ALEFLEEQLPELRKELEEAEAALEEFR-QKNGLVD-LSEEAKLLLQQLSEL---ESQLAEARAELAEAEARLAALRAQLG 250

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1145 IASRELE-----------KAKMAAANVSITQPESTGEPNN--MTLLAEEARRLAERHKQEADDI-------VRVAKTANE 1204
Cdd:COG3206   251 SGPDALPellqspviqqlRAQLAELEAELAELSARYTPNHpdVIALRAQIAALRAQLQQEAQRIlasleaeLEALQAREA 330

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 281371490 1205 TSAEAYNLLLRTLAGENQTALEIEELNRKYEQAKNISQDLEK--QAARVHEEAK 1256
Cdd:COG3206   331 SLQAQLAQLEARLAELPELEAELRRLEREVEVARELYESLLQrlEEARLAEALT 384
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1226-1450 8.23e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 43.67  E-value: 8.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1226 EIEELNRKYEQAKNISQDLEKQAARVHEEAKRA-----------GDKAVEIYASVAQLTPVD--------SEALESeank 1286
Cdd:COG3883    45 ELEELNEEYNELQAELEALQAEIDKLQAEIAEAeaeieerreelGERARALYRSGGSVSYLDvllgsesfSDFLDR---- 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1287 ikkeAADLDRLIDQ---KLKDYEDLREDMRGKEHEVKNLLEKGKAEQQTADQLlaradaakalaeeaakkgRNTLQEAND 1363
Cdd:COG3883   121 ----LSALSKIADAdadLLEELKADKAELEAKKAELEAKLAELEALKAELEAA------------------KAELEAQQA 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1364 ILNNLKDfdrRVNDNKTAAEEALRRIPAINRTIAEANEKTREAQLALGNAAADATEAKNKAHEAERIASGVQKNATSTKA 1443
Cdd:COG3883   179 EQEALLA---QLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAASAAGAGAAGAA 255


                  ....*..
gi 281371490 1444 DAERTFS 1450
Cdd:COG3883   256 GAAAGSA 262
MA smart00283
Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo ...
 1136-1419 9.62e-04

Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.


Pssm-ID: 214599 [Multi-domain]  Cd Length: 262  Bit Score: 43.04  E-value: 9.62e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490   1136 VESTEQLIEIASRELEKAKMAAanvsitqpestgepNNMTLLAEEARRLAERhkqeADDIVRVAKTANETSAEAYNLLLR 1215
Cdd:smart00283    3 SEAVEEIAAGAEEQAEELEELA--------------ERMEELSASIEEVAAN----ADEIAATAQSAAEAAEEGREAVED 64

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490   1216 TLAGENQTALEIEELNRKYEQAKNISQDLEKQAARVHE--------------EAKRAGDkAVEIYASVAQltpvdsE--A 1279
Cdd:smart00283   65 AITAMDQIREVVEEAVSAVEELEESSDEIGEIVSVIDDiadqtnllalnaaiEAARAGE-AGRGFAVVAD------EvrK 137

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490   1280 LeseANKIKKEAADLDRLIDQKLKDYEDLREDMRgkehEVKNLLEKGKAeqqtadqllaradaakalaeeaakKGRNTLQ 1359
Cdd:smart00283  138 L---AERSAESAKEIESLIKEIQEETNEAVAAME----ESSSEVEEGVE------------------------LVEETGD 186

                           250       260       270       280       290       300
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490   1360 EANDILNNLKDFDRRVNDNKTAAEEALRRIPAINRTIAEANEKTREAQlALGNAAADATE 1419
Cdd:smart00283  187 ALEEIVDSVEEIADLVQEIAAATDEQAAGSEEVNAAIDEIAQVTQETA-AMSEEISAAAE 245
PspA COG1842
Phage shock protein A [Transcription, Signal transduction mechanisms];
1279-1564 1.01e-03

Phage shock protein A [Transcription, Signal transduction mechanisms];


Pssm-ID: 441447 [Multi-domain]  Cd Length: 217  Bit Score: 42.50  E-value: 1.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1279 ALESEANKIKKEAADLDRLIDQKLKDYEDlredmrgkehevknllEKGKAEQQTADQllaradaakalaeeaakkgrntl 1358
Cdd:COG1842     9 IIRANINALLDKAEDPEKMLDQAIRDMEE----------------DLVEARQALAQV----------------------- 49

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1359 qeandilnnlkdfdrrvndnkTAAEEALRRipAINRTIAEANEKTREAQLALgnAAAD---ATEAknkaheAERIASgVQ 1435
Cdd:COG1842    50 ---------------------IANQKRLER--QLEELEAEAEKWEEKARLAL--EKGRedlAREA------LERKAE-LE 97

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1436 KNATSTKADAERTFSEVTDLDNEVNGMLRQLEEAENElkrkqddadQDMMMAGMASQAAQEAelnARKAKNSVSSllSQL 1515
Cdd:COG1842    98 AQAEALEAQLAQLEEQVEKLKEALRQLESKLEELKAK---------KDTLKARAKAAKAQEK---VNEALSGIDS--DDA 163

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 281371490 1516 TDLLEQLgqldtvdLNKLNEIEGSLNkAKDEMKV-SDLDRKVSNLENEAR 1564
Cdd:COG1842   164 TSALERM-------EEKIEEMEARAE-AAAELAAgDSLDDELAELEADSE 205
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 1039-1598 1.38e-03

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 43.50  E-value: 1.38e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1039 KVAEHRVKLQELESLIANLgtgdetvtdqafeDRLKEAEREVTDLLREAQEVkDVDQNLMDRLQRVNNSLHSQISRLHNI 1118
Cdd:TIGR00606  452 KQEELKFVIKELQQLEGSS-------------DRILELDQELRKAERELSKA-EKNSLTETLKKEVKSLQNEKADLDRKL 517

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1119 RNTIEEtgiLAERARSRvESTEQLIEIASRELEKAKMAAANVSITQPESTGEPN---NMTLLAEEARRLAERHKQEADDI 1195
Cdd:TIGR00606  518 RKLDQE---MEQLNHHT-TTRTQMEMLTKDKMDKDEQIRKIKSRHSDELTSLLGyfpNKKQLEDWLHSKSKEINQTRDRL 593

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1196 VRVAK--TANETSAEAYNLLLRTLagenqtaleiEELNRKYEQakNI-----SQDLEKQAARVHEEAKRAGDK------A 1262
Cdd:TIGR00606  594 AKLNKelASLEQNKNHINNELESK----------EEQLSSYED--KLfdvcgSQDEESDLERLKEEIEKSSKQramlagA 661

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1263 VEIYAS-VAQLTPVDSEA---------LESEANKIKKEAADLDRLIDQKLKDYEDLredMRGKEHEVKNLLEKGKAEQQT 1332
Cdd:TIGR00606  662 TAVYSQfITQLTDENQSCcpvcqrvfqTEAELQEFISDLQSKLRLAPDKLKSTESE---LKKKEKRRDEMLGLAPGRQSI 738

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1333 ADQLLaradaakalaeeaakkgrntlQEANDILNNLKDFDRRVNDNKTAAEEALRRIPAINrtiaeANEKTREAQLAlgn 1412
Cdd:TIGR00606  739 IDLKE---------------------KEIPELRNKLQKVNRDIQRLKNDIEEQETLLGTIM-----PEEESAKVCLT--- 789

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1413 aaaDATEAKNKAHEAERIASGV-QKNATSTKADAERTFSEVTDLDNEVNGMLRQLEEaENELKRKqddadqdmmmagmAS 1491
Cdd:TIGR00606  790 ---DVTIMERFQMELKDVERKIaQQAAKLQGSDLDRTVQQVNQEKQEKQHELDTVVS-KIELNRK-------------LI 852

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1492 QAAQEAELNARKAKNSVSSLLSQLTDLLEQLGQLDTVDLNKLNEIEgSLNKAKDEMKVSDL-------DRKVSNLENEAR 1564
Cdd:TIGR00606  853 QDQQEQIQHLKSKTNELKSEKLQIGTNLQRRQQFEEQLVELSTEVQ-SLIREIKDAKEQDSpletfleKDQQEKEELISS 931

                          570       580       590
                   ....*....|....*....|....*....|....*..
gi 281371490  1565 KQEAAILDYDR--DIAEIIKDIH-NLEDIKKTLPTGC 1598
Cdd:TIGR00606  932 KETSNKKAQDKvnDIKEKVKNIHgYMKDIENKIQDGK 968
PTZ00440 PTZ00440
reticulocyte binding protein 2-like protein; Provisional
 1033-1590 1.47e-03

reticulocyte binding protein 2-like protein; Provisional


Pssm-ID: 240419 [Multi-domain]  Cd Length: 2722  Bit Score: 43.67  E-value: 1.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1033 YRLVKDKVAEHRVKL-QELESLIANLGTGDETVTDQ--------AFEDRLKEAEREVTD---LLREAQE-VKDVDQNLMD 1099
Cdd:PTZ00440  740 YKEEEEKLEVYKHQIiNRKNEFILHLYENDKDLPDGkntyeeflQYKDTILNKENKISNdinILKENKKnNQDLLNSYNI 819

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1100 RLQRVNNSLHSQISRLHNIRNTIEETGI---LAE------RARSRVESTEQLIEIASRELEKAKmaaaNVSITQPESTGE 1170
Cdd:PTZ00440  820 LIQKLEAHTEKNDEELKQLLQKFPTEDEnlnLKElekefnENNQIVDNIIKDIENMNKNINIIK----TLNIAINRSNSN 895

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1171 PNNMTLLAEEARRLAERHKQ-----EADDIVRVAKTA------NETSAEAYNLLLRTLAgeNQTALEIEELNRKYEQAK- 1238
Cdd:PTZ00440  896 KQLVEHLLNNKIDLKNKLEQhmkiiNTDNIIQKNEKLnllnnlNKEKEKIEKQLSDTKI--NNLKMQIEKTLEYYDKSKe 973

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1239 NISQDLEKQAARVHEEAKRAGDKAVEIyasvAQLTpVDSEALESEANK-IKKEAADLDRLIDqklKDYEDLREDMRGKEH 1317
Cdd:PTZ00440  974 NINGNDGTHLEKLDKEKDEWEHFKSEI----DKLN-VNYNILNKKIDDlIKKQHDDIIELID---KLIKEKGKEIEEKVD 1045

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1318 EVKNLLEKGKAEQQTADQLLARAdaakalaeeaakkgrntLQEANDILNNLKDFDRRVNdnktaaeealrripAINRTIA 1397
Cdd:PTZ00440 1046 QYISLLEKMKTKLSSFHFNIDIK-----------------KYKNPKIKEEIKLLEEKVE--------------ALLKKID 1094

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1398 EANEKTREAQLALGNAAADATEAKNKAHEAERIAsgvQKNATSTKADAERTFSEVTDLDNEVNgMLRQLEEAENELKRK- 1476
Cdd:PTZ00440 1095 ENKNKLIEIKNKSHEHVVNADKEKNKQTEHYNKK---KKSLEKIYKQMEKTLKELENMNLEDI-TLNEVNEIEIEYERIl 1170

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1477 -QDDADQDMMMAGMASQAAQEAELNARK---AKNSVSSLLSQLTDLLEQLGQLDTVDLNKlNEIEGSLNKAKDEMKVSDL 1552
Cdd:PTZ00440 1171 iDHIVEQINNEAKKSKTIMEEIESYKKDidqVKKNMSKERNDHLTTFEYNAYYDKATASY-ENIEELTTEAKGLKGEANR 1249

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|.
gi 281371490 1553 DRKVSNLE---NEARKQEAAILDYDRDIAEIIKDIHNLEDI 1590
Cdd:PTZ00440 1250 STNVDELKeikLQVFSYLQQVIKENNKMENALHEIKNMYEF 1290
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1367-1594 1.47e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 43.51  E-value: 1.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1367 NLKDFDRRVNDNKTAAEEALRRIPAINRTIAEANEKTREAQLALGNAAA---DATEAKNKAHEAERIASGVQKNATSTKA 1443
Cdd:PRK03918  180 RLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKevkELEELKEEIEELEKELESLEGSKRKLEE 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1444 DaertFSEVTDLDNEVNGMLRQLEEAENELKRKQDDADQDMMMAGMASQAAQE-AELNARKAK-----NSVSSLLSQLTD 1517
Cdd:PRK03918  260 K----IRELEERIEELKKEIEELEEKVKELKELKEKAEEYIKLSEFYEEYLDElREIEKRLSRleeeiNGIEERIKELEE 335

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 281371490 1518 LLEQLGQLdtvdLNKLNEIEGSLNKAK-DEMKVSDLDRKVSNLENeARKQEAaildyDRDIAEIIKDIHNLEDIKKTL 1594
Cdd:PRK03918  336 KEERLEEL----KKKLKELEKRLEELEeRHELYEEAKAKKEELER-LKKRLT-----GLTPEKLEKELEELEKAKEEI 403
PLN03188 PLN03188
kinesin-12 family protein; Provisional
 1033-1307 1.79e-03

kinesin-12 family protein; Provisional


Pssm-ID: 215621 [Multi-domain]  Cd Length: 1320  Bit Score: 43.00  E-value: 1.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1033 YRLVKDKVAEHRVKLQ---ELESlianlgTGDETVTDQAFEDRlkeAEREVtdLLREAQEVKD-----VDQNLMDRLQRv 1104
Cdd:PLN03188  949 HKLLKEKYENHPEVLRtkiELKR------VQDELEHYRNFYDM---GEREV--LLEEIQDLRSqlqyyIDSSLPSARKR- 1016

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1105 nNSL--------HSQISRLHNIRNTIEETG-------------------ILAERARSRVESTEQLIEIASRELEKAKMAA 1157
Cdd:PLN03188 1017 -NSLlkltyscePSQAPPLNTIPESTDESPekkleqerlrwteaeskwiSLAEELRTELDASRALAEKQKHELDTEKRCA 1095

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1158 anvsitqpESTGEPNNMTL------------LAEEARRLAERHK--QEA-DDIVRVAKTANETSAEAYnlLLRTLAGEnQ 1222
Cdd:PLN03188 1096 --------EELKEAMQMAMegharmleqyadLEEKHIQLLARHRriQEGiDDVKKAAARAGVRGAESK--FINALAAE-I 1164

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1223 TALEIE-ELNRKYEQAKNISqdLEKQAARVHEEAKRAGDKAVEIYASVAQLTPVDSEALESEankikKEAADLDRLIDQK 1301
Cdd:PLN03188 1165 SALKVErEKERRYLRDENKS--LQAQLRDTAEAVQAAGELLVRLKEAEEALTVAQKRAMDAE-----QEAAEAYKQIDKL 1237


                  ....*.
gi 281371490 1302 LKDYED 1307
Cdd:PLN03188 1238 KRKHEN 1243
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1184-1415 2.03e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 42.02  E-value: 2.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1184 LAERHKQEADDIVRVAKTANETsAEAY----NLLLRTlaGENQTALEI-EELNRKYEQAKNISQDLekqaARVHEEAKRA 1258
Cdd:COG2956    20 LNGQPDKAIDLLEEALELDPET-VEAHlalgNLYRRR--GEYDRAIRIhQKLLERDPDRAEALLEL----AQDYLKAGLL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1259 gDKAVEIYASVAQLTPVDSEALESEANkIKKEAADLDRLIDQklkdYEDLREDMRGKEHevkNLLEKGKAEQQTADqlla 1338
Cdd:COG2956    93 -DRAEELLEKLLELDPDDAEALRLLAE-IYEQEGDWEKAIEV----LERLLKLGPENAH---AYCELAELYLEQGD---- 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1339 radaakalaeeaAKKGRNTLQEANDI-------LNNLKDFDRRVNDNKtAAEEALRRIPAINRTIAEANEKTREAQLALG 1411
Cdd:COG2956   160 ------------YDEAIEALEKALKLdpdcaraLLLLAELYLEQGDYE-EAIAALERALEQDPDYLPALPRLAELYEKLG 226


                  ....
gi 281371490 1412 NAAA 1415
Cdd:COG2956   227 DPEE 230
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1359-1505 2.04e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 41.45  E-value: 2.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1359 QEANDILNNLKDFDRRVNDNKTAAEEALRRIPAINRTIAEANEKTREAQLALGNaAADATEAKNKAHEaerIASgvQKNA 1438
Cdd:COG1579    31 AELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGN-VRNNKEYEALQKE---IES--LKRR 104

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 281371490 1439 TSTKADAERTFSE-VTDLDNEVNGMLRQLEEAENELKRKQDDADQDmmmagMASQAAQEAELNARKAK 1505
Cdd:COG1579   105 ISDLEDEILELMErIEELEEELAELEAELAELEAELEEKKAELDEE-----LAELEAELEELEAEREE 167
Borrelia_P83 pfam05262
Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.
 1291-1607 2.05e-03

Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.


Pssm-ID: 114011 [Multi-domain]  Cd Length: 489  Bit Score: 42.68  E-value: 2.05e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1291 AADLDRLIDQK-----LKDYE---DLREDMRG-KEHEVKNLLEKGKAEQQTADQLLaradaakalaeeaakkgrntlqea 1361
Cdd:pfam05262  171 DVDTDSISDKKvvealREDNEkgvNFRRDMTDlKERESQEDAKRAQQLKEELDKKQ------------------------ 226

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1362 ndilnnlKDFDRrvndnktAAEEALRRIPAINRTIAEANEKTREAQLALGNAAA-----DATEAKNKAHEAERIASGVQK 1436
Cdd:pfam05262  227 -------IDADK-------AQQKADFAQDNADKQRDEVRQKQQEAKNLPKPADTsspkeDKQVAENQKREIEKAQIEIKK 292

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1437 NA-TSTKADAERTFsevtDLDNEVNGMLRQLEEAENELKRKQDDADQDM--MMAGMASQAAQEAElNARKAKNSVSSLls 1513
Cdd:pfam05262  293 NDeEALKAKDHKAF----DLKQESKASEKEAEDKELEAQKKREPVAEDLqkTKPQVEAQPTSLNE-DAIDSSNPVYGL-- 365

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1514 QLTDLLEQLGQLDTVDLNK--------LNEIEGSL--NKAKDEMKVSD---------LDRKVSNLE-----NEARKQEAA 1569
Cdd:pfam05262  366 KVVDPITNLSELVLIDLKTevrlresaQQTIRRRGlyEREKDLVAIAItsgnaklqlVDIDLKNLEvikesNFEIAKNSS 445

                          330       340       350
                   ....*....|....*....|....*....|....*...
gi 281371490  1570 ILDYDRDIAEIIKDIHNLEDIKKTLPTGCFNTPSIEKP 1607
Cdd:pfam05262  446 LYVDSRMILVAVKDDSNKWRLAKFSPKLDEFILSENKI 483
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 1047-1526 2.33e-03

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 42.57  E-value: 2.33e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1047 LQELESLiANLGTGDETVTD--------QAFEDRLKEAEREVTDLLREAQEVKDVDQNLMDRLQRVNNSLHSQISRLhni 1118
Cdd:pfam07888    3 LDELVTL-EEESHGEEGGTDmllvvpraELLQNRLEECLQERAELLQAQEAANRQREKEKERYKRDREQWERQRREL--- 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1119 rntieetgilaeraRSRVESTEQLIEIASRELEKAKMAAANVSITQPESTGEPNnmTLLAEEARRLAeRHKQEADDIvrv 1198
Cdd:pfam07888   79 --------------ESRVAELKEELRQSREKHEELEEKYKELSASSEELSEEKD--ALLAQRAAHEA-RIRELEEDI--- 138

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1199 aktanetsaeaynlllRTLAgenQTALEIEelnrkyeqaknisQDLEkqaaRVHEEAKRAGDKAVEIYASVAQLTpVDSE 1278
Cdd:pfam07888  139 ----------------KTLT---QRVLERE-------------TELE----RMKERAKKAGAQRKEEEAERKQLQ-AKLQ 181

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1279 ALESEANKIKKEAADLDRLIDQKLKDYEDLREDmrgkeheVKNLLEK-GKAEQQTAdqllaradaakalaeeaakkgrnt 1357
Cdd:pfam07888  182 QTEEELRSLSKEFQELRNSLAQRDTQVLQLQDT-------ITTLTQKlTTAHRKEA------------------------ 230

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1358 lqEANDILNNLKDFDRRVNDNKTAAE---EALRRIPAI-NRTIAEANEKTRE-AQLALGNAAADATEAKNKAHEA-ERia 1431
Cdd:pfam07888  231 --ENEALLEELRSLQERLNASERKVEglgEELSSMAAQrDRTQAELHQARLQaAQLTLQLADASLALREGRARWAqER-- 306

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1432 SGVQKNATSTKADAERTFSEVTDLDNEVNGMLRQLEEAENELKRkqdDADQDMMMAGMASQAAQEAELNARKAKNSVSSL 1511
Cdd:pfam07888  307 ETLQQSAEADKDRIEKLSAELQRLEERLQEERMEREKLEVELGR---EKDCNRVQLSESRRELQELKASLRVAQKEKEQL 383

                          490
                   ....*....|....*
gi 281371490  1512 LSQLTDLLEQLGQLD 1526
Cdd:pfam07888  384 QAEKQELLEYIRQLE 398
CHASE3 COG5278
Extracytoplasmic sensor domain CHASE3 (specificity unknown) [Signal transduction mechanisms];
1264-1581 2.58e-03

Extracytoplasmic sensor domain CHASE3 (specificity unknown) [Signal transduction mechanisms];


Pssm-ID: 444089 [Multi-domain]  Cd Length: 530  Bit Score: 42.20  E-value: 2.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1264 EIYASVAQLtpvdsEALESEANKIKKEAADLDRLIDQKLKDYE---DLREDMRGKEHEVKNLLEKGKAEQQTADQLLARA 1340
Cdd:COG5278    87 EIDELLAEL-----RSLTADNPEQQARLDELEALIDQWLAELEqviALRRAGGLEAALALVRSGEGKALMDEIRARLLLL 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1341 DAAKALAEEAAKKGRNTLQEANDILNNLKDFDRRVNDNKTAAEEALRRIPAINRTIAEANEKTREAQLALGNAAADATEA 1420
Cdd:COG5278   162 ALALAALLLAAAALLLLLLALAALLALAELLLLALARALAALLLLLLLEAELAAAAALLAAAAALAALAALELLAALALA 241

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1421 KNKAHEAERIASGVQKNATSTKADAERTFSEVTDLDNEVNGMLRQLEEAENELKRKQDDADQDMMMAGMASQAAQEAELN 1500
Cdd:COG5278   242 LALLLAALLLALLAALALAALLAAALLALAALLLALAAAAALAAAAALELAAAEALALAELELELLLAAAAAAAAAAAAA 321

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1501 ARKAKNSVSSLLSQLTDLLEQLGQLDTVDL---NKLNEIEGSLNKAKDEMKVSDLDRKVSNLENEARKQEAAILDYDRDI 1577
Cdd:COG5278   322 AAALAALLALALATALAAAAAALALLAALLaeaAAAAAEEAEAAAEAAAAALAGLAEVEAEGAAEAVELEVLAIAAAAAA 401


                  ....
gi 281371490 1578 AEII 1581
Cdd:COG5278   402 AAAE 405
MscS_porin pfam12795
Mechanosensitive ion channel porin domain; The small mechanosensitive channel, MscS, is a part ...
 1271-1484 2.58e-03

Mechanosensitive ion channel porin domain; The small mechanosensitive channel, MscS, is a part of the turgor-driven solute efflux system that protects bacteria from lysis in the event of osmotic shock. The MscS protein alone is sufficient to form a functional mechanosensitive channel gated directly by tension in the lipid bilayer. The MscS proteins are heptamers of three transmembrane subunits with seven converging M3 domains, and this MscS_porin is towards the N-terminal of the molecules. The high concentration of negative charges at the extracellular entrance of the pore helps select the cations for efflux.


Pssm-ID: 432790 [Multi-domain]  Cd Length: 238  Bit Score: 41.52  E-value: 2.58e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1271 QLTPVDSEALES---------EANKIKKEAADLDRLIDQKLKDYEDLRED----MRGKEHEVKNLLEK---GKAEQQTAD 1334
Cdd:pfam12795   10 LDEAAKKKLLQDlqqalslldKIDASKQRAAAYQKALDDAPAELRELRQElaalQAKAEAAPKEILASlslEELEQRLLQ 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1335 QllaradaakalaeeaakkgRNTLQEANdilNNLKDFDRRVNDNKTAAE-------EALRRIPAINRTI---AEANEKTR 1404
Cdd:pfam12795   90 T-------------------SAQLQELQ---NQLAQLNSQLIELQTRPEraqqqlsEARQRLQQIRNRLngpAPPGEPLS 147

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1405 EAQLALGNAAADATEAKNKAHEAERIASGVQKNATSTKAD-----AERTFSEVTDLDNEVNGmlRQLEEAENELKRKQDD 1479
Cdd:pfam12795  148 EAQRWALQAELAALKAQIDMLEQELLSNNNRQDLLKARRDlltlrIQRLEQQLQALQELLNE--KRLQEAEQAVAQTEQL 225


                   ....*
gi 281371490  1480 ADQDM 1484
Cdd:pfam12795  226 AEEAA 230
SPEC cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
 1466-1594 2.71e-03

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


Pssm-ID: 238103 [Multi-domain]  Cd Length: 213  Bit Score: 40.89  E-value: 2.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1466 LEEAENELKRKQDDADQDMMMAGMASQAAQEAELNARKAKnsvsslLSQLTDLLEQLGQLDTVDLNKLNEIEGSLNKA-- 1543
Cdd:cd00176    16 LSEKEELLSSTDYGDDLESVEALLKKHEALEAELAAHEER------VEALNELGEQLIEEGHPDAEEIQERLEELNQRwe 89

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 281371490 1544 -------------KDEMKVSDLDRKVSNLENEARKQEAAIL--DYDRDIAEIIKDIHNLEDIKKTL 1594
Cdd:cd00176    90 elrelaeerrqrlEEALDLQQFFRDADDLEQWLEEKEAALAseDLGKDLESVEELLKKHKELEEEL 155
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1179-1409 2.76e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 42.06  E-value: 2.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1179 EEARRLAERHKQEADDIVRVAKTANETSAEAYNLLLRTLAGENQTALEIEELNRKYEQAKNISQDLEKQAARVHEEAKRA 1258
Cdd:COG4942    37 AELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEELAELLRALYRL 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1259 G-----------DKAVEIYASVAQLTPVdSEALESEANKIKKEAADLDRLIDQKLKDYEDLREDMRGKEHEvKNLLEKGK 1327
Cdd:COG4942   117 GrqpplalllspEDFLDAVRRLQYLKYL-APARREQAEELRADLAELAALRAELEAERAELEALLAELEEE-RAALEALK 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1328 AEQQTadqllaradaakalaeeaakkgrnTLQEANdilNNLKDFDRRVNDNKTAAEEALRRIPAINRTIAEANEKTREAQ 1407
Cdd:COG4942   195 AERQK------------------------LLARLE---KELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPAAG 247


                  ..
gi 281371490 1408 LA 1409
Cdd:COG4942   248 FA 249
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1250-1485 3.41e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 42.21  E-value: 3.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1250 RVHEEAKRAGDKaveiyasVAQLTPVdsEALESEANKIKKEAADLDRLIDqKLKDYEDLREDmrgkeHEVKNLLEKGKAE 1329
Cdd:COG4913   239 RAHEALEDAREQ-------IELLEPI--RELAERYAAARERLAELEYLRA-ALRLWFAQRRL-----ELLEAELEELRAE 303

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1330 QQTADQLLARAdaakalaeeaakkgRNTLQEANDILNNLKdfdRRVNDNKTAAEEALRRipainrTIAEANEKTREAQLA 1409
Cdd:COG4913   304 LARLEAELERL--------------EARLDALREELDELE---AQIRGNGGDRLEQLER------EIERLERELEERERR 360

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1410 LGNAAADAT----EAKNKAHEAERIASGVQKNATSTKADAERTFSEVTDLDNEVNGMLRQLEEAE---NELKRKQDDADQ 1482
Cdd:COG4913   361 RARLEALLAalglPLPASAEEFAALRAEAAALLEALEEELEALEEALAEAEAALRDLRRELRELEaeiASLERRKSNIPA 440


                  ...
gi 281371490 1483 DMM 1485
Cdd:COG4913   441 RLL 443
CENP-F_leu_zip pfam10473
Leucine-rich repeats of kinetochore protein Cenp-F/LEK1; Cenp-F, a centromeric kinetochore, ...
 1462-1568 3.72e-03

Leucine-rich repeats of kinetochore protein Cenp-F/LEK1; Cenp-F, a centromeric kinetochore, microtubule-binding protein consisting of two 1,600-amino acid-long coils, is essential for the full functioning of the mitotic checkpoint pathway. There are several leucine-rich repeats along the sequence of LEK1 that are considered to be zippers, though they do not appear to be binding DNA directly in this instance.


Pssm-ID: 463102 [Multi-domain]  Cd Length: 140  Bit Score: 39.59  E-value: 3.72e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1462 MLRQLEEAENE---LKRKQDDADQDMMMagmaSQAAQE-AELNARKAKNSVSSLLSQLTDLLEQLGQLdTVDLNKLNEIE 1537
Cdd:pfam10473    8 VLEKLKESERKadsLKDKVENLERELEM----SEENQElAILEAENSKAEVETLKAEIEEMAQNLRDL-ELDLVTLRSEK 82

                           90       100       110
                   ....*....|....*....|....*....|...
gi 281371490  1538 GSLNKAKDEM--KVSDLDRKVSNLENEARKQEA 1568
Cdd:pfam10473   83 ENLTKELQKKqeRVSELESLNSSLENLLEEKEQ 115
COG5022 COG5022
Myosin heavy chain [General function prediction only];
1079-1566 4.35e-03

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 41.99  E-value: 4.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1079 EVTDLLREAQevKDVDQNLMDRLQRVNNSLHSQISRLH----NIRNTIEETGILAER---ARSRVESTEQLIEIASRELE 1151
Cdd:COG5022   932 RLKKLLNNID--LEEGPSIEYVKLPELNKLHEVESKLKetseEYEDLLKKSTILVREgnkANSELKNFKKELAELSKQYG 1009

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1152 KAKMAAANVSITQPESTGEPNNMTLLAEEarRLAERHKQEADDIVRVA-KTANETSAEAYNLLLRTlagENQTALEieel 1230
Cdd:COG5022  1010 ALQESTKQLKELPVEVAELQSASKIISSE--STELSILKPLQKLKGLLlLENNQLQARYKALKLRR---ENSLLDD---- 1080

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1231 nrkyeqaknisqDLEKQAARVHEEAKragdkavEIYASVAQLTPVDSEALESEANKIKKEAADLDRLID------QKLKD 1304
Cdd:COG5022  1081 ------------KQLYQLESTENLLK-------TINVKDLEVTNRNLVKPANVLQFIVAQMIKLNLLQEiskflsQLVNT 1141

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1305 YEDLREDMRGKEHEVKNLLEKGKAEQQTAdqllaradaakalaeeaaKKGRNTLQEANDILNNLKDF-----DRRVNDNK 1379
Cdd:COG5022  1142 LEPVFQKLSVLQLELDGLFWEANLEALPS------------------PPPFAALSEKRLYQSALYDEksklsSSEVNDLK 1203

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1380 TAAEEALRRIP-------AINRTIAEANEKTREAQLALGNAAAD---ATEAKNKAHEAERIASGVQKNATSTKADAERTF 1449
Cdd:COG5022  1204 NELIALFSKIFsgwprgdKLKKLISEGWVPTEYSTSLKGFNNLNkkfDTPASMSNEKLLSLLNSIDNLLSSYKLEEEVLP 1283

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1450 SEVTDLDNEVNGMLRQ-LEEAENELKRKQddadqdmmmagmASQAAQEAELNARKAKNS-VSSLLSQLTDLLE--QLGQL 1525
Cdd:COG5022  1284 ATINSLLQYINVGLFNaLRTKASSLRWKS------------ATEVNYNSEELDDWCREFeISDVDEELEELIQavKVLQL 1351

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|..
gi 281371490 1526 DTVDLNKLNEIEGSLNKAKD-EMKVSDLDRKVSNLENEARKQ 1566
Cdd:COG5022  1352 LKDDLNKLDELLDACYSLNPaEIQNLKSRYDPADKENNLPKE 1393
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 1235-1495 5.05e-03

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 40.98  E-value: 5.05e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1235 EQAKNISQDLEKQAARVHEEAKRAGDKAVEiyasvAQltpvdsEALESEANKIKKEAADLDRliDQKLKDYEDLREDMRG 1314
Cdd:TIGR02794   50 QQANRIQQQKKPAAKKEQERQKKLEQQAEE-----AE------KQRAAEQARQKELEQRAAA--EKAAKQAEQAAKQAEE 116

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1315 KEHEVKNLLEKGKAEQQTADQLLARadaakalaeeaakkgrntlQEANDILNNLKDFDRRVN---DNKTAAEEALRRIPA 1391
Cdd:TIGR02794  117 KQKQAEEAKAKQAAEAKAKAEAEAE-------------------RKAKEEAAKQAEEEAKAKaaaEAKKKAEEAKKKAEA 177

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1392 INRTIAEAnektrEAQLALGNAAADATEAKNKAhEAERIASGVQKNATSTKADAERTFSEVTDLDnevngmLRQLEEAEN 1471
Cdd:TIGR02794  178 EAKAKAEA-----EAKAKAEEAKAKAEAAKAKA-AAEAAAKAEAEAAAAAAAEAERKADEAELGD------IFGLASGSN 245

                          250       260
                   ....*....|....*....|....
gi 281371490  1472 elKRKQDDADQDMMMAGMASQAAQ 1495
Cdd:TIGR02794  246 --AEKQGGARGAAAGSEVDKYAAI 267
FlgN pfam05130
FlgN protein; This family includes the FlgN protein and export chaperone involved in flagellar ...
 1048-1121 5.19e-03

FlgN protein; This family includes the FlgN protein and export chaperone involved in flagellar synthesis.


Pssm-ID: 428323 [Multi-domain]  Cd Length: 140  Bit Score: 38.89  E-value: 5.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1048 QELESLIANLGTGDETVTDQAFE------DRLKEAEREVTDLLREAQEVKDVDQNLMDRLQRVNNSLHSQISRLHNIRNT 1121
Cdd:pfam05130   55 KERRELLAELGLSPEEATLSELLakeeedPELRELWQELLELLERLKELNELNGELIEQSLEFNNRSLNILQGAANGSNT 134
Lebercilin pfam15619
Ciliary protein causing Leber congenital amaurosis disease; Lebercilin is a family of ...
 1179-1296 5.20e-03

Ciliary protein causing Leber congenital amaurosis disease; Lebercilin is a family of eukaryotic ciliary proteins. Mutations in the gene, LCA5, are implicated in the disease Leber congenital amaurosis. In photoreceptors, lebercilin is uniquely localized at the cilium that bridges the inner and outer segments. Lebercilin functions as an integral element of selective protein transport through photoreceptor cilia. Lebercilin specifically interacts with the intraflagellar transport (IFT), and disruption of IFT can lead to Leber congenital amaurosis.


Pssm-ID: 464776 [Multi-domain]  Cd Length: 193  Bit Score: 39.89  E-value: 5.20e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1179 EEARRLAERHKQEADDIVRVAKTANETSAEAYNLL-----LRTLAgENQTALEIEELNRK-------YEQAKNISQDLEK 1246
Cdd:pfam15619   67 EEVRVLRERLRRLQEKERDLERKLKEKEAELLRLRdqlkrLEKLS-EDKNLAEREELQKKleqleakLEDKDEKIQDLER 145

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 281371490  1247 Q-----AARVHEEAkRAGDKAVEIYASVAQltpvdseaLESEANKIKKEAADLDR 1296
Cdd:pfam15619  146 KlelenKSFRRQLA-AEKKKHKEAQEEVKI--------LQEEIERLQQKLKEKER 191
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1177-1533 5.29e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 41.44  E-value: 5.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1177 LAEEARRLAERHKQEADDI--VRVAKTANETSAEAYNLLLRTLAGEN---QTALEIEELNRKYEQAKNISQDLEKQAARV 1251
Cdd:COG4913   615 LEAELAELEEELAEAEERLeaLEAELDALQERREALQRLAEYSWDEIdvaSAEREIAELEAELERLDASSDDLAALEEQL 694

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1252 hEEAKRAGDKAVEiyasvaqltpvDSEALESEANKIKKEAADLDRLIDQKLKDYEDLreDMRGKEHEVKNLLEKGKAEQQ 1331
Cdd:COG4913   695 -EELEAELEELEE-----------ELDELKGEIGRLEKELEQAEEELDELQDRLEAA--EDLARLELRALLEERFAAALG 760

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1332 TADQLLAradaakalaeeaakkgRNTLQEANDILNNLKDfdrrvndnktAAEEALRRIpainrtIAEANEKTREAQLALG 1411
Cdd:COG4913   761 DAVEREL----------------RENLEERIDALRARLN----------RAEEELERA------MRAFNREWPAETADLD 808

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1412 NAAADATE--------AKNKAHEAE-RIASGVQKNATSTKAD----AERTFSEVTDLDNEVNGMLRQLEEAEN-----EL 1473
Cdd:COG4913   809 ADLESLPEylalldrlEEDGLPEYEeRFKELLNENSIEFVADllskLRRAIREIKERIDPLNDSLKRIPFGPGrylrlEA 888

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 281371490 1474 KRKQDDAD---QDMMMAgmASQAAQEAELNARKAK-NSVSSLLSQLTDlleQLGQLDTVDLNKL 1533
Cdd:COG4913   889 RPRPDPEVrefRQELRA--VTSGASLFDEELSEARfAALKRLIERLRS---EEEESDRRWRARV 947
PRK07735 PRK07735
NADH-quinone oxidoreductase subunit C;
1303-1507 5.75e-03

NADH-quinone oxidoreductase subunit C;


Pssm-ID: 236081 [Multi-domain]  Cd Length: 430  Bit Score: 41.12  E-value: 5.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1303 KDYEDLREDM--RGKEHEVKNLLEKGKAEQQTADQLLARADAAKALAEEAakkgrnTLQEANdilnnlkdfdrrvndnKT 1380
Cdd:PRK07735    5 KDLEDLKKEAarRAKEEARKRLVAKHGAEISKLEEENREKEKALPKNDDM------TIEEAK----------------RR 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1381 AAEEALRRIPAINRTIAEANEKTREAQLALGNAAAdATEAKNKAHEAERI-------ASGVQKNATSTKADAERTfsevt 1453
Cdd:PRK07735   63 AAAAAKAKAAALAKQKREGTEEVTEEEKAKAKAKA-AAAAKAKAAALAKQkregteeVTEEEKAAAKAKAAAAAK----- 136

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 281371490 1454 dldNEVNGMLRQLEEAENELKRKQDDADQDMMMAGMASQA-AQEAELNARKAKNS 1507
Cdd:PRK07735  137 ---AKAAALAKQKREGTEEVTEEEEETDKEKAKAKAAAAAkAKAAALAKQKAAEA 188
Tropomyosin pfam00261
Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 ...
 1067-1295 6.71e-03

Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 parallel helices containing 2 sets of 7 alternating actin binding sites. The protein is best known for its role in regulating the interaction between actin and myosin in muscle contraction, but is also involved in the organization and dynamics of the cytoskeleton in non-muscle cells. There are multiple cell-specific isoforms, expressed by alternative promoters and alternative RNA processing of at least four genes. Muscle isoforms of tropomyosin are characterized by having 284 amino acid residues and a highly conserved N-terminal region, whereas non-muscle forms are generally smaller and are heterogeneous in their N-terminal region.


Pssm-ID: 459736 [Multi-domain]  Cd Length: 235  Bit Score: 40.01  E-value: 6.71e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1067 QAFEDRLKEAEREVTDLLREAQEVKDVDQNLMDRLQRVNNSLHSQISRLHNIRNTIEEtgilAERARSRVESTEQLIEIA 1146
Cdd:pfam00261   18 KEAMKKLEEAEKRAEKAEAEVAALNRRIQLLEEELERTEERLAEALEKLEEAEKAADE----SERGRKVLENRALKDEEK 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490  1147 SRELEkakmAAANVSITQPESTGEPnnmtlLAEEARRLAERhKQEADDIVRVAKTANETSAEAYNLL------LRTLAGE 1220
Cdd:pfam00261   94 MEILE----AQLKEAKEIAEEADRK-----YEEVARKLVVV-EGDLERAEERAELAESKIVELEEELkvvgnnLKSLEAS 163

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 281371490  1221 NQTALEIEELNRkyEQAKNISQDLeKQAARVHEEAKRagdKAVEIYASVAQLtpvdSEALESEANKIKKEAADLD 1295
Cdd:pfam00261  164 EEKASEREDKYE--EQIRFLTEKL-KEAETRAEFAER---SVQKLEKEVDRL----EDELEAEKEKYKAISEELD 228
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1036-1344 6.99e-03

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 41.18  E-value: 6.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1036 VKDKVAEHRVKLQELESLIAN----LGTGD-----ETVTDQAFEDRLKEAEREVTDLLREAQEVKDVDQNLMDRLQRVNN 1106
Cdd:PRK02224  424 LREREAELEATLRTARERVEEaealLEAGKcpecgQPVEGSPHVETIEEDRERVEELEAELEDLEEEVEEVEERLERAED 503

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1107 --SLHSQISRLHNIRNTIEEtgiLAERARSRVESTEQLIEiasrELEKAKmaaanvsiTQPESTGEPNNMTllAEEARRL 1184
Cdd:PRK02224  504 lvEAEDRIERLEERREDLEE---LIAERRETIEEKRERAE----ELRERA--------AELEAEAEEKREA--AAEAEEE 566

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1185 AERHKQEADDIVRvAKTANETSAEAYNLLLRTLAGENQTALEIEELNRKYEQAknisQDLEKQAaRVHEEAKRagDKAVE 1264
Cdd:PRK02224  567 AEEAREEVAELNS-KLAELKERIESLERIRTLLAAIADAEDEIERLREKREAL----AELNDER-RERLAEKR--ERKRE 638

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1265 IYASVaqltpvDSEALEsEANKIKKEAADLDRLIDQKLKDYEDLREDMRGKEHEVKNLLEKGKAEQQTADQLLARADAAK 1344
Cdd:PRK02224  639 LEAEF------DEARIE-EAREDKERAEEYLEQVEEKLDELREERDDLQAEIGAVENELEELEELRERREALENRVEALE 711
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
1153-1535 8.07e-03

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 40.77  E-value: 8.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1153 AKMAAANVSITQPESTGEPNNMTLLAEEARRLAERHKQEADDIVRVAKTANETSAEAYNLLLRTLAGENQTALEIEELnR 1232
Cdd:COG0840     6 LLLALLLALLLLALSLLALLAAALLILLALLLAALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVVLLA-L 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1233 KYEQAKNISQDLEKQAARVHEEAKRAGDKAVEIYASVAQLTPVDSEALESEANKIKKEAADLDRLIDQKLKDYEDLREDM 1312
Cdd:COG0840    85 LLALLLLLLALLALALAALALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAAAALA 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1313 RGKEHEVKNLLEKGKAEQQTADQLLARADAAKALAEEAAKKGRNTLQEANDILNNLKDFDRRVNDNKTAAEE--ALRRip 1390
Cdd:COG0840   165 ALLEAAALALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEigQLAD-- 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1391 AINRTIAEANEKTREAQLALGNAAADATEAknkAHEAERIASGVQKNATSTkadaERTFSEVTDLDNEVNGMlrqleeAE 1470
Cdd:COG0840   243 AFNRMIENLRELVGQVRESAEQVASASEEL---AASAEELAAGAEEQAASL----EETAAAMEELSATVQEV------AE 309

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 281371490 1471 NelkrkqddadqdmmmAGMASQAAQEAELNARKAKNSVSSLLSQLTDLLEQLGQLDTVdLNKLNE 1535
Cdd:COG0840   310 N---------------AQQAAELAEEASELAEEGGEVVEEAVEGIEEIRESVEETAET-IEELGE 358
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
284-326 8.91e-03

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 35.75  E-value: 8.91e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 281371490    284 CKCNGHASECVKNEFGKLVCNCKHNTYGVDCEKCLPFFNDRPW 326
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGP 43
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1226-1335 9.16e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 39.52  E-value: 9.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281371490 1226 EIEELNRKYEQAKNISQDLEKQAARVHEEAKRAGDKAVEIYASVAQL-TPVDSEALESEANKIKKEAADLDRLIDQKLKD 1304
Cdd:COG1579    39 ELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVrNNKEYEALQKEIESLKRRISDLEDEILELMER 118

                          90       100       110
                  ....*....|....*....|....*....|.
gi 281371490 1305 YEDLREDMRGKEHEVKNLLEKGKAEQQTADQ 1335
Cdd:COG1579   119 IEELEEELAELEAELAELEAELEEKKAELDE 149
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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