|
Name |
Accession |
Description |
Interval |
E-value |
| GadA |
COG0076 |
Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport ... |
127-573 |
1.82e-136 |
|
Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport and metabolism]; Glutamate or tyrosine decarboxylase or a related PLP-dependent protein is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis
Pssm-ID: 439846 [Multi-domain] Cd Length: 460 Bit Score: 404.60 E-value: 1.82e-136
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136594 127 EPAELRQLFDFQLREQGESQDK-LRELLRETIRFSVKTGHPYFINQLYSGVDPYALVGQWLTDALNPSVYTYEVAPLFTL 205
Cdd:COG0076 28 SPEELRAALDEPLPEEGLPPEEaLAELEDLVLPGSVDWNHPRFLAFVTGGTTPAALAADLLASALNQNMGDWDTSPAATE 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136594 206 MEEQVLAEMRRIVGFPNGGqgDGIFCPGGSIANGYAISCARYRHSPE-SKKNGLFNAKPLIIFTSEDAHYSVEKLAMFMG 284
Cdd:COG0076 108 LEREVVRWLADLLGLPEGA--GGVFTSGGTEANLLALLAARDRALARrVRAEGLPGAPRPRIVVSEEAHSSVDKAARLLG 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136594 285 FGSDHVRKIATNEVGKMRLSDLEKQVKLCLENGWQPLMVSATAGTTVLGAFDDLAGISEVCKKYNMWMHVDAAWGGGALM 364
Cdd:COG0076 186 LGRDALRKVPVDEDGRMDPDALEAAIDEDRAAGLNPIAVVATAGTTNTGAIDPLAEIADIAREHGLWLHVDAAYGGFALP 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136594 365 SKKYRHLLNGIERADSVTWNPHKLLAASQQCSTFLTRHQQVLAQCHSTNATYLFQKDkfyDTSFDTGDKHIQCGRRADVF 444
Cdd:COG0076 266 SPELRHLLDGIERADSITVDPHKWLYVPYGCGAVLVRDPELLREAFSFHASYLGPAD---DGVPNLGDYTLELSRRFRAL 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136594 445 KFWFMWKAKGTQGLEAHVEKVFRMAEFFTAKVRERPGFELVLEsPECTNISFWYVPPGLREM-ERNREFYDRLHkvapkv 523
Cdd:COG0076 343 KLWATLRALGREGYRELIERCIDLARYLAEGIAALPGFELLAP-PELNIVCFRYKPAGLDEEdALNYALRDRLR------ 415
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 17136594 524 kegmiKKGSMMITYQPLRQLPNfFRLVLQNSCLEESDMVYFLDEIESLAQ 573
Cdd:COG0076 416 -----ARGRAFLSPTKLDGRVV-LRLVVLNPRTTEDDVDALLDDLREAAA 459
|
|
| Pyridoxal_deC |
pfam00282 |
Pyridoxal-dependent decarboxylase conserved domain; |
128-499 |
1.69e-116 |
|
Pyridoxal-dependent decarboxylase conserved domain;
Pssm-ID: 395219 Cd Length: 373 Bit Score: 350.18 E-value: 1.69e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136594 128 PAELRQLFDFQLREQGESQDKLRELLRETIRFSVKTGH-PYFINQLYSGVDPYALVGQWLTDALNPSVYTYEVAPLFTLM 206
Cdd:pfam00282 1 PGYLKPLLPLAAPIIPEPELQIDGDIRRNLMPGVTTWHsPHFHAYMPTGNSYPSLLGDMLTDAINCNGFTWESSPACTEL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136594 207 EEQVLAEMRRIVGFP---NGGQGDGIFCPGGSIANGYAISCARYRHSPESKKNG------LFNAKpLIIFTSEDAHYSVE 277
Cdd:pfam00282 81 ENVVMNWLGEMLGLPaefLGQEGGGVLQPGSSESNLLALLAARTKWIKRMKAAGkpadssGILAK-LVAYTSDQAHSSIE 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136594 278 KLAMFMGFGsdhVRKIATNEVGKMRLSDLEKQVKLCLENGWQPLMVSATAGTTVLGAFDDLAGISEVCKKYNMWMHVDAA 357
Cdd:pfam00282 160 KAALYGGVK---LREIPSDDNGKMRGMDLEKAIEEDKENGLIPFFVVATLGTTGSGAFDDLQELGDICAKHNLWLHVDAA 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136594 358 WGGGALMSKKYRHLLNGIERADSVTWNPHKLLAASQQCSTFLTRHQQVLAQCHSTNATYLFQKDKFYdtsfDTGDKHIQC 437
Cdd:pfam00282 237 YGGSAFICPEFRHWLFGIERADSITFNPHKWMLVLLDCSAVWVKDKEALQQAFQFNPLYLGHTDSAY----DTGHKQIPL 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17136594 438 GRRADVFKFWFMWKAKGTQGLEAHVEKVFRMAEFFTAKVRERPGFELVLEsPECTNISFWYV 499
Cdd:pfam00282 313 SRRFRILKLWFVIRSLGVEGLQNQIRRHVELAQYLEALIRKDGRFEICAE-VGLGLVCFRLK 373
|
|
| DOPA_deC_like |
cd06450 |
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
168-571 |
5.75e-114 |
|
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and glutamate decarboxylase (GDC). DDC is active as a dimer and catalyzes the decarboxylation of tyrosine. GDC catalyzes the decarboxylation of glutamate and HDC catalyzes the decarboxylation of histidine.
Pssm-ID: 99743 [Multi-domain] Cd Length: 345 Bit Score: 342.65 E-value: 5.75e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136594 168 FINQLYSGVDPYALVGQWLTDALNPSVYTYEVAPLFTLMEEQVLAEMRRIVGFPNGgQGDGIFCPGGSIANGYAISCARY 247
Cdd:cd06450 1 FLAGFVTTMDPPALLLEMLTSAKNAIDFTWDESPAATEMEAEVVNWLAKLFGLPSE-DADGVFTSGGSESNLLALLAARD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136594 248 RHSPESKKNGLFNAKPLIIFTSEDAHYSVEKLAMFMGfgsDHVRKIATNEVGKMRLSDLEKQVKLCLENGWQPLMVSATA 327
Cdd:cd06450 80 RARKRLKAGGGRGIDKLVIVCSDQAHVSVEKAAAYLD---VKVRLVPVDEDGRMDPEALEAAIDEDKAEGLNPIMVVATA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136594 328 GTTVLGAFDDLAGISEVCKKYNMWMHVDAAWGGGALMSKKYRHLLNGIERADSVTWNPHKLLAASQQCSTFLTRhqqvla 407
Cdd:cd06450 157 GTTDTGAIDPLEEIADLAEKYDLWLHVDAAYGGFLLPFPEPRHLDFGIERVDSISVDPHKYGLVPLGCSAVLVR------ 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136594 408 qchstnatylfqkdkfydtsfdtgdkhiqcgrradVFKFWFMWKAKGTQGLEAHVEKVFRMAEFFTAKVRERPGFELVlE 487
Cdd:cd06450 231 -----------------------------------ALKLWATLRRFGRDGYGEHIDRIVDLAKYLAELIRADPGFELL-G 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136594 488 SPECTNISFWYVPPglremernrefyDRLHKVAPKVKEGMIKKGSMMITYQPLRQlPNFFRLVLQNSCLEESDMVYFLDE 567
Cdd:cd06450 275 EPNLSLVCFRLKPS------------VKLDELNYDLSDRLNERGGWHVPATTLGG-PNVLRFVVTNPLTTRDDADALLED 341
|
....
gi 17136594 568 IESL 571
Cdd:cd06450 342 IERA 345
|
|
| PLN02880 |
PLN02880 |
tyrosine decarboxylase |
127-519 |
6.65e-38 |
|
tyrosine decarboxylase
Pssm-ID: 215475 [Multi-domain] Cd Length: 490 Bit Score: 146.21 E-value: 6.65e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136594 127 EPAELRQLFDFQLREQGESQDKLRELLRETIRFSVKTGH-PYFINQLYSGVDPYALVGQWLTDALNPSVYTYEVAPLFTL 205
Cdd:PLN02880 43 QPGYLRELLPDSAPNQPETLDQVLDDVQAKILPGVTHWQsPNYFAYYPSNSSVAGFLGEMLSAGLNIVGFSWITSPAATE 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136594 206 MEEQVLAEMRRIVGFP----NGGQGDGIFCPGGSIANGYAISCARYRHSPESKKNGLfnaKPLIIFTSEDAHYSVEKLAM 281
Cdd:PLN02880 123 LEMIVLDWLAKLLNLPeqflSTGNGGGVIQGTASEAVLVVLLAARDRVLRKVGKNAL---EKLVVYASDQTHSALQKACQ 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136594 282 FMGFGSDHVRKIATNEVGKMRLSD--LEKQVKLCLENGWQPLMVSATAGTTVLGAFDDLAGISEVCKKYNMWMHVDAAWG 359
Cdd:PLN02880 200 IAGIHPENCRLLKTDSSTNYALAPelLSEAISTDLSSGLIPFFLCATVGTTSSTAVDPLLELGKIAKSNGMWFHVDAAYA 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136594 360 GGALMSKKYRHLLNGIERADSVTWNPHKLLAASQQCSTFLTRHQQVLAQCHSTNATYLFQKDKFYDTSFDTGDKHIQCGR 439
Cdd:PLN02880 280 GSACICPEYRHYIDGVEEADSFNMNAHKWFLTNFDCSLLWVKDRNALIQSLSTNPEFLKNKASQANSVVDYKDWQIPLGR 359
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136594 440 RADVFKFWFMWKAKGTQGLEAHVEKVFRMAEFFTAKVRERPGFELVlESPECTNISFWYVPPGLREMERNREFYDRLHKV 519
Cdd:PLN02880 360 RFRSLKLWMVLRLYGVENLQSYIRNHIKLAKEFEQLVAQDSRFEVV-TPRIFSLVCFRLVPPKNNEDNGNKLNHDLLDAV 438
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| GadA |
COG0076 |
Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport ... |
127-573 |
1.82e-136 |
|
Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport and metabolism]; Glutamate or tyrosine decarboxylase or a related PLP-dependent protein is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis
Pssm-ID: 439846 [Multi-domain] Cd Length: 460 Bit Score: 404.60 E-value: 1.82e-136
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136594 127 EPAELRQLFDFQLREQGESQDK-LRELLRETIRFSVKTGHPYFINQLYSGVDPYALVGQWLTDALNPSVYTYEVAPLFTL 205
Cdd:COG0076 28 SPEELRAALDEPLPEEGLPPEEaLAELEDLVLPGSVDWNHPRFLAFVTGGTTPAALAADLLASALNQNMGDWDTSPAATE 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136594 206 MEEQVLAEMRRIVGFPNGGqgDGIFCPGGSIANGYAISCARYRHSPE-SKKNGLFNAKPLIIFTSEDAHYSVEKLAMFMG 284
Cdd:COG0076 108 LEREVVRWLADLLGLPEGA--GGVFTSGGTEANLLALLAARDRALARrVRAEGLPGAPRPRIVVSEEAHSSVDKAARLLG 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136594 285 FGSDHVRKIATNEVGKMRLSDLEKQVKLCLENGWQPLMVSATAGTTVLGAFDDLAGISEVCKKYNMWMHVDAAWGGGALM 364
Cdd:COG0076 186 LGRDALRKVPVDEDGRMDPDALEAAIDEDRAAGLNPIAVVATAGTTNTGAIDPLAEIADIAREHGLWLHVDAAYGGFALP 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136594 365 SKKYRHLLNGIERADSVTWNPHKLLAASQQCSTFLTRHQQVLAQCHSTNATYLFQKDkfyDTSFDTGDKHIQCGRRADVF 444
Cdd:COG0076 266 SPELRHLLDGIERADSITVDPHKWLYVPYGCGAVLVRDPELLREAFSFHASYLGPAD---DGVPNLGDYTLELSRRFRAL 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136594 445 KFWFMWKAKGTQGLEAHVEKVFRMAEFFTAKVRERPGFELVLEsPECTNISFWYVPPGLREM-ERNREFYDRLHkvapkv 523
Cdd:COG0076 343 KLWATLRALGREGYRELIERCIDLARYLAEGIAALPGFELLAP-PELNIVCFRYKPAGLDEEdALNYALRDRLR------ 415
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 17136594 524 kegmiKKGSMMITYQPLRQLPNfFRLVLQNSCLEESDMVYFLDEIESLAQ 573
Cdd:COG0076 416 -----ARGRAFLSPTKLDGRVV-LRLVVLNPRTTEDDVDALLDDLREAAA 459
|
|
| Pyridoxal_deC |
pfam00282 |
Pyridoxal-dependent decarboxylase conserved domain; |
128-499 |
1.69e-116 |
|
Pyridoxal-dependent decarboxylase conserved domain;
Pssm-ID: 395219 Cd Length: 373 Bit Score: 350.18 E-value: 1.69e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136594 128 PAELRQLFDFQLREQGESQDKLRELLRETIRFSVKTGH-PYFINQLYSGVDPYALVGQWLTDALNPSVYTYEVAPLFTLM 206
Cdd:pfam00282 1 PGYLKPLLPLAAPIIPEPELQIDGDIRRNLMPGVTTWHsPHFHAYMPTGNSYPSLLGDMLTDAINCNGFTWESSPACTEL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136594 207 EEQVLAEMRRIVGFP---NGGQGDGIFCPGGSIANGYAISCARYRHSPESKKNG------LFNAKpLIIFTSEDAHYSVE 277
Cdd:pfam00282 81 ENVVMNWLGEMLGLPaefLGQEGGGVLQPGSSESNLLALLAARTKWIKRMKAAGkpadssGILAK-LVAYTSDQAHSSIE 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136594 278 KLAMFMGFGsdhVRKIATNEVGKMRLSDLEKQVKLCLENGWQPLMVSATAGTTVLGAFDDLAGISEVCKKYNMWMHVDAA 357
Cdd:pfam00282 160 KAALYGGVK---LREIPSDDNGKMRGMDLEKAIEEDKENGLIPFFVVATLGTTGSGAFDDLQELGDICAKHNLWLHVDAA 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136594 358 WGGGALMSKKYRHLLNGIERADSVTWNPHKLLAASQQCSTFLTRHQQVLAQCHSTNATYLFQKDKFYdtsfDTGDKHIQC 437
Cdd:pfam00282 237 YGGSAFICPEFRHWLFGIERADSITFNPHKWMLVLLDCSAVWVKDKEALQQAFQFNPLYLGHTDSAY----DTGHKQIPL 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17136594 438 GRRADVFKFWFMWKAKGTQGLEAHVEKVFRMAEFFTAKVRERPGFELVLEsPECTNISFWYV 499
Cdd:pfam00282 313 SRRFRILKLWFVIRSLGVEGLQNQIRRHVELAQYLEALIRKDGRFEICAE-VGLGLVCFRLK 373
|
|
| DOPA_deC_like |
cd06450 |
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
168-571 |
5.75e-114 |
|
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and glutamate decarboxylase (GDC). DDC is active as a dimer and catalyzes the decarboxylation of tyrosine. GDC catalyzes the decarboxylation of glutamate and HDC catalyzes the decarboxylation of histidine.
Pssm-ID: 99743 [Multi-domain] Cd Length: 345 Bit Score: 342.65 E-value: 5.75e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136594 168 FINQLYSGVDPYALVGQWLTDALNPSVYTYEVAPLFTLMEEQVLAEMRRIVGFPNGgQGDGIFCPGGSIANGYAISCARY 247
Cdd:cd06450 1 FLAGFVTTMDPPALLLEMLTSAKNAIDFTWDESPAATEMEAEVVNWLAKLFGLPSE-DADGVFTSGGSESNLLALLAARD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136594 248 RHSPESKKNGLFNAKPLIIFTSEDAHYSVEKLAMFMGfgsDHVRKIATNEVGKMRLSDLEKQVKLCLENGWQPLMVSATA 327
Cdd:cd06450 80 RARKRLKAGGGRGIDKLVIVCSDQAHVSVEKAAAYLD---VKVRLVPVDEDGRMDPEALEAAIDEDKAEGLNPIMVVATA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136594 328 GTTVLGAFDDLAGISEVCKKYNMWMHVDAAWGGGALMSKKYRHLLNGIERADSVTWNPHKLLAASQQCSTFLTRhqqvla 407
Cdd:cd06450 157 GTTDTGAIDPLEEIADLAEKYDLWLHVDAAYGGFLLPFPEPRHLDFGIERVDSISVDPHKYGLVPLGCSAVLVR------ 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136594 408 qchstnatylfqkdkfydtsfdtgdkhiqcgrradVFKFWFMWKAKGTQGLEAHVEKVFRMAEFFTAKVRERPGFELVlE 487
Cdd:cd06450 231 -----------------------------------ALKLWATLRRFGRDGYGEHIDRIVDLAKYLAELIRADPGFELL-G 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136594 488 SPECTNISFWYVPPglremernrefyDRLHKVAPKVKEGMIKKGSMMITYQPLRQlPNFFRLVLQNSCLEESDMVYFLDE 567
Cdd:cd06450 275 EPNLSLVCFRLKPS------------VKLDELNYDLSDRLNERGGWHVPATTLGG-PNVLRFVVTNPLTTRDDADALLED 341
|
....
gi 17136594 568 IESL 571
Cdd:cd06450 342 IERA 345
|
|
| PLN02880 |
PLN02880 |
tyrosine decarboxylase |
127-519 |
6.65e-38 |
|
tyrosine decarboxylase
Pssm-ID: 215475 [Multi-domain] Cd Length: 490 Bit Score: 146.21 E-value: 6.65e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136594 127 EPAELRQLFDFQLREQGESQDKLRELLRETIRFSVKTGH-PYFINQLYSGVDPYALVGQWLTDALNPSVYTYEVAPLFTL 205
Cdd:PLN02880 43 QPGYLRELLPDSAPNQPETLDQVLDDVQAKILPGVTHWQsPNYFAYYPSNSSVAGFLGEMLSAGLNIVGFSWITSPAATE 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136594 206 MEEQVLAEMRRIVGFP----NGGQGDGIFCPGGSIANGYAISCARYRHSPESKKNGLfnaKPLIIFTSEDAHYSVEKLAM 281
Cdd:PLN02880 123 LEMIVLDWLAKLLNLPeqflSTGNGGGVIQGTASEAVLVVLLAARDRVLRKVGKNAL---EKLVVYASDQTHSALQKACQ 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136594 282 FMGFGSDHVRKIATNEVGKMRLSD--LEKQVKLCLENGWQPLMVSATAGTTVLGAFDDLAGISEVCKKYNMWMHVDAAWG 359
Cdd:PLN02880 200 IAGIHPENCRLLKTDSSTNYALAPelLSEAISTDLSSGLIPFFLCATVGTTSSTAVDPLLELGKIAKSNGMWFHVDAAYA 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136594 360 GGALMSKKYRHLLNGIERADSVTWNPHKLLAASQQCSTFLTRHQQVLAQCHSTNATYLFQKDKFYDTSFDTGDKHIQCGR 439
Cdd:PLN02880 280 GSACICPEYRHYIDGVEEADSFNMNAHKWFLTNFDCSLLWVKDRNALIQSLSTNPEFLKNKASQANSVVDYKDWQIPLGR 359
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136594 440 RADVFKFWFMWKAKGTQGLEAHVEKVFRMAEFFTAKVRERPGFELVlESPECTNISFWYVPPGLREMERNREFYDRLHKV 519
Cdd:PLN02880 360 RFRSLKLWMVLRLYGVENLQSYIRNHIKLAKEFEQLVAQDSRFEVV-TPRIFSLVCFRLVPPKNNEDNGNKLNHDLLDAV 438
|
|
| PLN02590 |
PLN02590 |
probable tyrosine decarboxylase |
113-512 |
3.55e-36 |
|
probable tyrosine decarboxylase
Pssm-ID: 178200 [Multi-domain] Cd Length: 539 Bit Score: 142.16 E-value: 3.55e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136594 113 FQGTNRSSKVVEWHEPAELRQLFDFQLREQGESqdkLRELLRETIRfSVKTG-----HPYFINQLYSGVDPYALVGQWLT 187
Cdd:PLN02590 77 LQDSPQDFPVLSQVQPGYLRDMLPDSAPERPES---LKELLDDVSK-KIMPGithwqSPSYFAYYASSTSVAGFLGEMLN 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136594 188 DALNPSVYTYEVAPLFTLMEEQVLAEMRRIVGFPN----GGQGDGIFCPGGSIANGYAISCARYRhspESKKNGLFNAKP 263
Cdd:PLN02590 153 AGLSVVGFTWLTSPAATELEIIVLDWLAKLLQLPDhflsTGNGGGVIQGTGCEAVLVVVLAARDR---ILKKVGKTLLPQ 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136594 264 LIIFTSEDAHYSVEKLAMFMGFGSDHVRKIATNEVGK--MRLSDLEKQVKLCLENGWQPLMVSATAGTTVLGAFDDLAGI 341
Cdd:PLN02590 230 LVVYGSDQTHSSFRKACLIGGIHEENIRLLKTDSSTNygMPPESLEEAISHDLAKGFIPFFICATVGTTSSAAVDPLVPL 309
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136594 342 SEVCKKYNMWMHVDAAWGGGALMSKKYRHLLNGIERADSVTWNPHKLLAASQQCSTFLTRHQQVLAQCHSTNATYLFQKD 421
Cdd:PLN02590 310 GNIAKKYGIWLHVDAAYAGNACICPEYRKFIDGIENADSFNMNAHKWLFANQTCSPLWVKDRYSLIDALKTNPEYLEFKV 389
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136594 422 KFYDTSFDTGDKHIQCGRRADVFKFWFMWKAKGTQGLEAHVEKVFRMAEFFTAKVRERPGFElVLESPECTNISFWYVPP 501
Cdd:PLN02590 390 SKKDTVVNYKDWQISLSRRFRSLKLWMVLRLYGSENLRNFIRDHVNLAKHFEDYVAQDPSFE-VVTTRYFSLVCFRLAPV 468
|
410
....*....|....
gi 17136594 502 GLREM---ERNREF 512
Cdd:PLN02590 469 DGDEDqcnERNREL 482
|
|
| PRK02769 |
PRK02769 |
histidine decarboxylase; Provisional |
257-479 |
6.43e-19 |
|
histidine decarboxylase; Provisional
Pssm-ID: 235068 [Multi-domain] Cd Length: 380 Bit Score: 88.95 E-value: 6.43e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136594 257 GLFNAKPL----IIFTSEDAHYSVEKLAMFMGFGSdhvRKIATNEVGKMRLSDLEKQVKlclENGWQPLMVSATAGTTVL 332
Cdd:PRK02769 100 GCYLARELfpdgTLYYSKDTHYSVSKIARLLRIKS---RVITSLPNGEIDYDDLISKIK---ENKNQPPIIFANIGTTMT 173
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136594 333 GAFDDLAGISEVCKKYNM---WMHVDAAWGGGALMSKKYRHLLNGIERADSVTWNPHKLLAASQQCSTFLTRHQQVlaQC 409
Cdd:PRK02769 174 GAIDNIKEIQEILKKIGIddyYIHADAALSGMILPFVNNPPPFSFADGIDSIAISGHKFIGSPMPCGIVLAKKKYV--ER 251
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17136594 410 HSTNATYLfqkdkfydtsfDTGDKHIQCGRRAdvFKFWFMWKA---KGTQGLEAHVEKVFRMAEFFTAKVRER 479
Cdd:PRK02769 252 ISVDVDYI-----------GSRDQTISGSRNG--HTALLLWAAirsLGSKGLRQRVQHCLDMAQYAVDRLQAN 311
|
|
| PLN02263 |
PLN02263 |
serine decarboxylase |
265-478 |
8.93e-13 |
|
serine decarboxylase
Pssm-ID: 177904 [Multi-domain] Cd Length: 470 Bit Score: 70.62 E-value: 8.93e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136594 265 IIFTSEDAHYSVEKLAMFMGFGSDhvrKIATNEVGKMRLSDLEKQVklcLENGWQPLMVSATAGTTVLGAFDDLAGISEV 344
Cdd:PLN02263 180 ILYASRESHYSVFKAARMYRMECV---KVDTLVSGEIDCADFKAKL---LANKDKPAIINVNIGTTVKGAVDDLDLVIKT 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136594 345 CKKY-----NMWMHVDAAWGGgaLMskkyrhlLNGIERADSVTWNP---------HKLLAASQQCSTFLTR--HQQVLaq 408
Cdd:PLN02263 254 LEECgfsqdRFYIHCDGALFG--LM-------MPFVKRAPKVTFKKpigsvsvsgHKFVGCPMPCGVQITRmeHINVL-- 322
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136594 409 chSTNATYLFQKDKfydTSFDTGDKHiqcgrrADVFkFWFMWKAKGTQGLEAHVEKVFRMAEFFTAKVRE 478
Cdd:PLN02263 323 --SSNVEYLASRDA---TIMGSRNGH------APIF-LWYTLNRKGYRGFQKEVQKCLRNAHYLKDRLRE 380
|
|
| PLN03032 |
PLN03032 |
serine decarboxylase; Provisional |
265-478 |
2.33e-11 |
|
serine decarboxylase; Provisional
Pssm-ID: 166673 [Multi-domain] Cd Length: 374 Bit Score: 65.62 E-value: 2.33e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136594 265 IIFTSEDAHYSVEKLAMFMGFgsdHVRKIATNEVGKMRLSDLEKQVklcLENGWQPLMVSATAGTTVLGAFDDLAGISEV 344
Cdd:PLN03032 113 ILYASRESHYSVFKAARMYRM---EAVKVPTLPSGEIDYDDLERAL---AKNRDKPAILNVNIGTTVKGAVDDLDRILRI 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136594 345 CKKYNM-----WMHVDAAWGGGALMSKKYRHLLNGIERADSVTWNPHKLLAASQQCSTFLTRHQQVLAQchSTNATYLFQ 419
Cdd:PLN03032 187 LKELGYtedrfYIHCDGALFGLMMPFVSRAPEVTFRKPIGSVSVSGHKFLGCPMPCGVALTRKKHVKAL--SQNVEYLNS 264
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 17136594 420 KDKfydTSFDTGDKHiqcgrrADVFkFWFMWKAKGTQGLEAHVEKVFRMAEFFTAKVRE 478
Cdd:PLN03032 265 RDA---TIMGSRNGH------APLY-LWYTLRRKGYRGIKRDVQHCMRNAHYLKDRLTE 313
|
|
| AAT_I |
cd01494 |
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ... |
214-393 |
2.79e-09 |
|
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).
Pssm-ID: 99742 [Multi-domain] Cd Length: 170 Bit Score: 56.62 E-value: 2.79e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136594 214 MRRIVGFPNGGQGDGIFCPGGSIANGYAISCARYRHSPeskknglfnakpliIFTSEDAHYSVE--KLAMFmGFGSDHVR 291
Cdd:cd01494 6 EEKLARLLQPGNDKAVFVPSGTGANEAALLALLGPGDE--------------VIVDANGHGSRYwvAAELA-GAKPVPVP 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136594 292 KiatNEVGKMRLS--DLEKqvklcLENGWQPLMVSATAGTTVLGAFDDLAGISEVCKKYNMWMHVDAAWGGGALMSKKYr 369
Cdd:cd01494 71 V---DDAGYGGLDvaILEE-----LKAKPNVALIVITPNTTSGGVLVPLKEIRKIAKEYGILLLVDAASAGGASPAPGV- 141
|
170 180
....*....|....*....|....
gi 17136594 370 hlLNGIERADSVTWNPHKLLAASQ 393
Cdd:cd01494 142 --LIPEGGADVVTFSLHKNLGGEG 163
|
|
| Aminotran_5 |
pfam00266 |
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes ... |
229-357 |
3.58e-06 |
|
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-.
Pssm-ID: 425567 [Multi-domain] Cd Length: 368 Bit Score: 49.55 E-value: 3.58e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136594 229 IFCPGGSIANGYAISCarYRHSPESKKNglfnakpliIFTSEDAHYSV----EKLAMFMGFgsdHVRKIATNEVGKMRLS 304
Cdd:pfam00266 65 IFTSGTTEAINLVALS--LGRSLKPGDE---------IVITEMEHHANlvpwQELAKRTGA---RVRVLPLDEDGLLDLD 130
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 17136594 305 DLEK----QVKLclengwqplmVSATAGTTVLGAFDDLAGISEVCKKYNMWMHVDAA 357
Cdd:pfam00266 131 ELEKlitpKTKL----------VAITHVSNVTGTIQPVPEIGKLAHQYGALVLVDAA 177
|
|
| Orn_deC_like |
cd00615 |
Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
333-419 |
1.67e-04 |
|
Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine decarboxylase (LDC). ODC is a dodecamer composed of six homodimers and catalyzes the decarboxylation of tryptophan. ADC catalyzes the decarboxylation of arginine and LDC catalyzes the decarboxylation of lysine. Members of this family are widely found in all three forms of life.
Pssm-ID: 99739 [Multi-domain] Cd Length: 294 Bit Score: 43.78 E-value: 1.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136594 333 GAFDDLAGISEVCKKYNMWMHVDAAWGGGALMSKKY--RHLLNGierADSVTWNPHKLLAASQQCSTFLTRHQQVLAQcH 410
Cdd:cd00615 167 GICYNLRKIVEEAHHRGLPVLVDEAHGAHFRFHPILpsSAAMAG---ADIVVQSTHKTLPALTQGSMIHVKGDLVNPD-R 242
|
....*....
gi 17136594 411 STNATYLFQ 419
Cdd:cd00615 243 VNEALNLHQ 251
|
|
| PRK02948 |
PRK02948 |
IscS subfamily cysteine desulfurase; |
208-356 |
4.01e-04 |
|
IscS subfamily cysteine desulfurase;
Pssm-ID: 179511 [Multi-domain] Cd Length: 381 Bit Score: 42.79 E-value: 4.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136594 208 EQVLAEMRRIVGFPNGGQGDGI-FCPGGSIANGYAIscaryrhspESKKNGLFNAKPLIIfTSEDAHYSVEKLAMFM--- 283
Cdd:PRK02948 42 SSLLQVCRKTFAEMIGGEEQGIyFTSGGTESNYLAI---------QSLLNALPQNKKHII-TTPMEHASIHSYFQSLesq 111
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17136594 284 GFgsdHVRKIATNEVGKMRLSDLEKQVKLclengwQPLMVSATAGTTVLGAFDDLAGISEVCKKYNMWMHVDA 356
Cdd:PRK02948 112 GY---TVTEIPVDKSGLIRLVDLERAITP------DTVLASIQHANSEIGTIQPIAEIGALLKKYNVLFHSDC 175
|
|
| Beta_elim_lyase |
pfam01212 |
Beta-eliminating lyase; |
212-357 |
1.61e-03 |
|
Beta-eliminating lyase;
Pssm-ID: 426128 [Multi-domain] Cd Length: 288 Bit Score: 40.66 E-value: 1.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136594 212 AEMRRIVGFPNGgqgdgIFCPGGSIANGYAIS--CARYrHSpeskknglfnakpliIFTSEDAHYSVEKLAMFMGFGSDH 289
Cdd:pfam01212 39 DRVAELFGKEAA-----LFVPSGTAANQLALMahCQRG-DE---------------VICGEPAHIHFDETGGHAELGGVQ 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136594 290 VRKIATNEVGKMRLSDLEKQVK------------LCLENgwqplmVSATAGTTVLgAFDDLAGISEVCKKYNMWMHVDAA 357
Cdd:pfam01212 98 PRPLDGDEAGNMDLEDLEAAIRevgadifpptglISLEN------THNSAGGQVV-SLENLREIAALAREHGIPVHLDGA 170
|
|
| LdcC |
COG1982 |
Arginine/lysine/ornithine decarboxylase [Amino acid transport and metabolism]; |
333-405 |
1.74e-03 |
|
Arginine/lysine/ornithine decarboxylase [Amino acid transport and metabolism];
Pssm-ID: 441585 [Multi-domain] Cd Length: 486 Bit Score: 41.25 E-value: 1.74e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17136594 333 GAFDDLAGISEVCKKYNMWMHVDAAWGGGALMSKKYRH--LLNGierADSVTWNPHKLLAASQQCSTFLTRHQQV 405
Cdd:COG1982 174 GVCYDLKAIAELAHEHGIPVLVDEAHGAHFGFHPDLPRsaMEAG---ADLVVQSTHKTLGALTQSSMLHVKGGRV 245
|
|
| TA_like |
cd06502 |
Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP) ... |
228-357 |
2.44e-03 |
|
Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a secondary glycine biosynthetic pathway.
Pssm-ID: 99748 [Multi-domain] Cd Length: 338 Bit Score: 40.39 E-value: 2.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136594 228 GIFCPGGSIANGYAIS--CARYrHSpeskknglfnakpliIFTSEDAH---YSVEKLAMFMGfgsdHVRKIATNEVGKMR 302
Cdd:cd06502 50 ALFVPSGTAANQLALAahTQPG-GS---------------VICHETAHiytDEAGAPEFLSG----VKLLPVPGENGKLT 109
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17136594 303 LSDLEKQVK------------LCLENgwqplmvsaTAGTTVLGAFDDLAGISEVCKKYNMWMHVDAA 357
Cdd:cd06502 110 PEDLEAAIRprddihfpppslVSLEN---------TTEGGTVYPLDELKAISALAKENGLPLHLDGA 167
|
|
| |
