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Conserved domains on  [gi|18859301|ref|NP_571519|]
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small ribosomal subunit protein RACK1 [Danio rerio]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-311 1.02e-95

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 284.61  E-value: 1.02e-95
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859301   8 RGTLKGHSGWVTQIATTPQfPDMILSASRDKTIIMWKLTRDEtnygiPQRALRGHSHFVSDVVISSDGQFALSGSWDGTL 87
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLETGE-----LLRTLKGHTGPVRDVAASADGTYLASGSSDKTI 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859301  88 RLWDLTTGTTTRRFVGHTKDVLSVAFSADNRQIVSGSRDKTIKLWNTL-GVCKYTIQDdsHTEWVSCVRFSPNssNPIIV 166
Cdd:cd00200  76 RLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVEtGKCLTTLRG--HTDWVNSVAFSPD--GTFVA 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859301 167 SCGWDKMVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-GDTINALCFSPNR 245
Cdd:cd00200 152 SSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAFSPDG 231

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 18859301 246 YWLCAATG-PSIKIWDLEGKIIVDELrqdiittnsKAEPPQCTSLAWSADGQTLFAGYTDNLIRVWQ 311
Cdd:cd00200 232 YLLASGSEdGTIRVWDLRTGECVQTL---------SGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-311 1.02e-95

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 284.61  E-value: 1.02e-95
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859301   8 RGTLKGHSGWVTQIATTPQfPDMILSASRDKTIIMWKLTRDEtnygiPQRALRGHSHFVSDVVISSDGQFALSGSWDGTL 87
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLETGE-----LLRTLKGHTGPVRDVAASADGTYLASGSSDKTI 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859301  88 RLWDLTTGTTTRRFVGHTKDVLSVAFSADNRQIVSGSRDKTIKLWNTL-GVCKYTIQDdsHTEWVSCVRFSPNssNPIIV 166
Cdd:cd00200  76 RLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVEtGKCLTTLRG--HTDWVNSVAFSPD--GTFVA 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859301 167 SCGWDKMVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-GDTINALCFSPNR 245
Cdd:cd00200 152 SSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAFSPDG 231

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 18859301 246 YWLCAATG-PSIKIWDLEGKIIVDELrqdiittnsKAEPPQCTSLAWSADGQTLFAGYTDNLIRVWQ 311
Cdd:cd00200 232 YLLASGSEdGTIRVWDLRTGECVQTL---------SGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
6-317 4.72e-79

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 245.98  E-value: 4.72e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859301   6 TVRGTLKGHSGWVTQIATTPQfPDMILSASRDKTIIMWKLTRdetnyGIPQRALRGHSHFVSDVVISSDGQFALSGSWDG 85
Cdd:COG2319  69 ALLATLLGHTAAVLSVAFSPD-GRLLASASADGTVRLWDLAT-----GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADG 142

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859301  86 TLRLWDLTTGTTTRRFVGHTKDVLSVAFSADNRQIVSGSRDKTIKLWNTL-GVCKYTIQDdsHTEWVSCVRFSPNSSnpI 164
Cdd:COG2319 143 TVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLTG--HTGAVRSVAFSPDGK--L 218

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859301 165 IVSCGWDKMVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-GDTINALCFSP 243
Cdd:COG2319 219 LASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGhSGGVNSVAFSP 298

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 18859301 244 NRYWLCAATG-PSIKIWDLEGKIIVDELrqdiittnsKAEPPQCTSLAWSADGQTLFAGYTDNLIRVWQVTIGTR 317
Cdd:COG2319 299 DGKLLASGSDdGTVRLWDLATGKLLRTL---------TGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGEL 364
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 80-222 1.73e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 58.94  E-value: 1.73e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859301   80 SGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAF-SADNRQIVSGSRDKTIKLWN-TLGVCKYTIQDDSHtewVSCVRFs 157
Cdd:PLN00181 550 SSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYsSADPTLLASGSDDGSVKLWSiNQGVSIGTIKTKAN---ICCVQF- 625

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 18859301  158 PNSSNPIIVSCGWDKMVKVWNLANCKLK-TNHIGHTGYLNTVTVSpDGSLCASGGKDGQAMLWDLN 222
Cdd:PLN00181 626 PSESGRSLAFGSADHKVYYYDLRNPKLPlCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDLS 690
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 94-133 2.77e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.23  E-value: 2.77e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 18859301     94 TGTTTRRFVGHTKDVLSVAFSADNRQIVSGSRDKTIKLWN 133
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
95-133 4.89e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.50  E-value: 4.89e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 18859301    95 GTTTRRFVGHTKDVLSVAFSADNRQIVSGSRDKTIKLWN 133
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-311 1.02e-95

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 284.61  E-value: 1.02e-95
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859301   8 RGTLKGHSGWVTQIATTPQfPDMILSASRDKTIIMWKLTRDEtnygiPQRALRGHSHFVSDVVISSDGQFALSGSWDGTL 87
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLETGE-----LLRTLKGHTGPVRDVAASADGTYLASGSSDKTI 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859301  88 RLWDLTTGTTTRRFVGHTKDVLSVAFSADNRQIVSGSRDKTIKLWNTL-GVCKYTIQDdsHTEWVSCVRFSPNssNPIIV 166
Cdd:cd00200  76 RLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVEtGKCLTTLRG--HTDWVNSVAFSPD--GTFVA 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859301 167 SCGWDKMVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-GDTINALCFSPNR 245
Cdd:cd00200 152 SSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAFSPDG 231

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 18859301 246 YWLCAATG-PSIKIWDLEGKIIVDELrqdiittnsKAEPPQCTSLAWSADGQTLFAGYTDNLIRVWQ 311
Cdd:cd00200 232 YLLASGSEdGTIRVWDLRTGECVQTL---------SGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
6-317 4.72e-79

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 245.98  E-value: 4.72e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859301   6 TVRGTLKGHSGWVTQIATTPQfPDMILSASRDKTIIMWKLTRdetnyGIPQRALRGHSHFVSDVVISSDGQFALSGSWDG 85
Cdd:COG2319  69 ALLATLLGHTAAVLSVAFSPD-GRLLASASADGTVRLWDLAT-----GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADG 142

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859301  86 TLRLWDLTTGTTTRRFVGHTKDVLSVAFSADNRQIVSGSRDKTIKLWNTL-GVCKYTIQDdsHTEWVSCVRFSPNSSnpI 164
Cdd:COG2319 143 TVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLTG--HTGAVRSVAFSPDGK--L 218

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859301 165 IVSCGWDKMVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-GDTINALCFSP 243
Cdd:COG2319 219 LASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGhSGGVNSVAFSP 298

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 18859301 244 NRYWLCAATG-PSIKIWDLEGKIIVDELrqdiittnsKAEPPQCTSLAWSADGQTLFAGYTDNLIRVWQVTIGTR 317
Cdd:COG2319 299 DGKLLASGSDdGTVRLWDLATGKLLRTL---------TGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGEL 364
WD40 COG2319
WD40 repeat [General function prediction only];
6-313 4.41e-78

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 243.66  E-value: 4.41e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859301   6 TVRGTLKGHSGWVTQIATTPqfpD--MILSASRDKTIIMWKLTRdetnyGIPQRALRGHSHFVSDVVISSDGQFALSGSW 83
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSP---DgkTLASGSADGTVRLWDLAT-----GKLLRTLTGHSGAVTSVAFSPDGKLLASGSD 182

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859301  84 DGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSADNRQIVSGSRDKTIKLWNTL-GVCKYTIQDdsHTEWVSCVRFSPNSSn 162
Cdd:COG2319 183 DGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAtGKLLRTLTG--HSGSVRSVAFSPDGR- 259

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859301 163 pIIVSCGWDKMVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-GDTINALCF 241
Cdd:COG2319 260 -LLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGhTGAVRSVAF 338

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 18859301 242 SPNRYWLCAATGP-SIKIWDLEGKIIVDELR--QDIIttnskaeppqcTSLAWSADGQTLFAGYTDNLIRVWQVT 313
Cdd:COG2319 339 SPDGKTLASGSDDgTVRLWDLATGELLRTLTghTGAV-----------TSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
6-317 3.72e-65

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 210.54  E-value: 3.72e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859301   6 TVRGTLKGHSGWVTQIATTPQfPDMILSASRDKTIIMWKLTRdetnyGIPQRALRGHSHFVSDVVISSDGQFALSGSWDG 85
Cdd:COG2319  27 ALLLLLLGLAAAVASLAASPD-GARLAAGAGDLTLLLLDAAA-----GALLATLLGHTAAVLSVAFSPDGRLLASASADG 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859301  86 TLRLWDLTTGTTTRRFVGHTKDVLSVAFSADNRQIVSGSRDKTIKLWNTL-GVCKYTIQDdsHTEWVSCVRFSPNSSnpI 164
Cdd:COG2319 101 TVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAtGKLLRTLTG--HSGAVTSVAFSPDGK--L 176

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859301 165 IVSCGWDKMVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-GDTINALCFSP 243
Cdd:COG2319 177 LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGhSGSVRSVAFSP 256

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 18859301 244 NRYWLCAATG-PSIKIWDLEGKIIVDELrqdiittnsKAEPPQCTSLAWSADGQTLFAGYTDNLIRVWQVTIGTR 317
Cdd:COG2319 257 DGRLLASGSAdGTVRLWDLATGELLRTL---------TGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKL 322
WD40 COG2319
WD40 repeat [General function prediction only];
43-317 4.87e-53

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 178.95  E-value: 4.87e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859301  43 WKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSADNRQIVS 122
Cdd:COG2319  16 LALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLAS 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859301 123 GSRDKTIKLWNTLGVcKYTIQDDSHTEWVSCVRFSPNSSnpIIVSCGWDKMVKVWNLANCKLKTNHIGHTGYLNTVTVSP 202
Cdd:COG2319  96 ASADGTVRLWDLATG-LLLRTLTGHTGAVRSVAFSPDGK--TLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSP 172

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859301 203 DGSLCASGGKDGQAMLWDLNEGKHLYTLDG-GDTINALCFSPN-RYWLCAATGPSIKIWDLEGKIIVDELrqdiittnsK 280
Cdd:COG2319 173 DGKLLASGSDDGTVRLWDLATGKLLRTLTGhTGAVRSVAFSPDgKLLASGSADGTVRLWDLATGKLLRTL---------T 243

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 18859301 281 AEPPQCTSLAWSADGQTLFAGYTDNLIRVWQVTIGTR 317
Cdd:COG2319 244 GHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGEL 280
WD40 COG2319
WD40 repeat [General function prediction only];
6-181 3.30e-45

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 158.15  E-value: 3.30e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859301   6 TVRGTLKGHSGWVTQIATTPQfPDMILSASRDKTIIMWKLTRDEtnygiPQRALRGHSHFVSDVVISSDGQFALSGSWDG 85
Cdd:COG2319 237 KLLRTLTGHSGSVRSVAFSPD-GRLLASGSADGTVRLWDLATGE-----LLRTLTGHSGGVNSVAFSPDGKLLASGSDDG 310

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859301  86 TLRLWDLTTGTTTRRFVGHTKDVLSVAFSADNRQIVSGSRDKTIKLWNTL-GVCKYTIQDdsHTEWVSCVRFSPNSSnpI 164
Cdd:COG2319 311 TVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLAtGELLRTLTG--HTGAVTSVAFSPDGR--T 386

                       170
                ....*....|....*..
gi 18859301 165 IVSCGWDKMVKVWNLAN 181
Cdd:COG2319 387 LASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2-133 7.50e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 106.65  E-value: 7.50e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859301   2 TEQMTVRGTLKGHSGWVTQIATTPQfPDMILSASRDKTIIMWkltrdETNYGIPQRALRGHSHFVSDVVISSDGQFALSG 81
Cdd:cd00200 164 LRTGKCVATLTGHTGEVNSVAFSPD-GEKLLSSSSDGTIKLW-----DLSTGKCLGTLRGHENGVNSVAFSPDGYLLASG 237

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 18859301  82 SWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSADNRQIVSGSRDKTIKLWN 133
Cdd:cd00200 238 SEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 80-222 1.73e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 58.94  E-value: 1.73e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859301   80 SGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAF-SADNRQIVSGSRDKTIKLWN-TLGVCKYTIQDDSHtewVSCVRFs 157
Cdd:PLN00181 550 SSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYsSADPTLLASGSDDGSVKLWSiNQGVSIGTIKTKAN---ICCVQF- 625

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 18859301  158 PNSSNPIIVSCGWDKMVKVWNLANCKLK-TNHIGHTGYLNTVTVSpDGSLCASGGKDGQAMLWDLN 222
Cdd:PLN00181 626 PSESGRSLAFGSADHKVYYYDLRNPKLPlCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDLS 690
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 108-314 4.34e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 57.40  E-value: 4.34e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859301  108 VLSVAFSADNRQIVSGSRDKTIKLWNtlgvCKYTIQD--DSHTEWVSCVRFSPNSS-------NPIIVSCGWDKMVKVWN 178
Cdd:PLN00181 486 VCAIGFDRDGEFFATAGVNKKIKIFE----CESIIKDgrDIHYPVVELASRSKLSGicwnsyiKSQVASSNFEGVVQVWD 561

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859301  179 LANCKLKTNHIGHTGYLNTVTVSP-DGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDTINALCFSpnrywlcAATGPSIK 257
Cdd:PLN00181 562 VARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFP-------SESGRSLA 634

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 18859301  258 IWDLEGKIIVDELRQDIIttnskaepPQCTSLAWS--------ADGQTLFAGYTDNLIRVWQVTI 314
Cdd:PLN00181 635 FGSADHKVYYYDLRNPKL--------PLCTMIGHSktvsyvrfVDSSTLVSSSTDNTLKLWDLSM 691
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 94-133 2.77e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.23  E-value: 2.77e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 18859301     94 TGTTTRRFVGHTKDVLSVAFSADNRQIVSGSRDKTIKLWN 133
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
95-133 4.89e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.50  E-value: 4.89e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 18859301    95 GTTTRRFVGHTKDVLSVAFSADNRQIVSGSRDKTIKLWN 133
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
53-91 6.25e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.11  E-value: 6.25e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 18859301    53 GIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWD 91
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 31-219 2.67e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 52.01  E-value: 2.67e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859301   31 ILSASRDKTIIMWKLTRDETnygipQRALRGHSHFVSDVVISS-DGQFALSGSWDGTLRLWDLTTGTTtrrfVGHTK--- 106
Cdd:PLN00181 548 VASSNFEGVVQVWDVARSQL-----VTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVS----IGTIKtka 618

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859301  107 DVLSVAFSADN-RQIVSGSRDKTIKLWN----TLGVCKYTiqddSHTEWVSCVRFSPNSSnpiIVSCGWDKMVKVWNLAN 181
Cdd:PLN00181 619 NICCVQFPSESgRSLAFGSADHKVYYYDlrnpKLPLCTMI----GHSKTVSYVRFVDSST---LVSSSTDNTLKLWDLSM 691

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 18859301  182 CKLKTNH------IGHTGYLNTVTVSPDGSLCASGGKDGQAMLW 219
Cdd:PLN00181 692 SISGINEtplhsfMGHTNVKNFVGLSVSDGYIATGSETNEVFVY 735
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 53-91 5.19e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 5.19e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 18859301     53 GIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWD 91
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 136-178 8.21e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 8.21e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 18859301    136 GVCKYTIQddSHTEWVSCVRFSPNSSnpIIVSCGWDKMVKVWN 178
Cdd:smart00320   2 GELLKTLK--GHTGPVTSVAFSPDGK--YLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 102-213 1.10e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 46.81  E-value: 1.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859301  102 VGHTKDVLSVAFSA-DNRQIVSGSRDKTIKLWN------TLGVCKYTIQDDSHTEWVSCVRFSPnSSNPIIVSCGWDKMV 174
Cdd:PTZ00421  72 LGQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGipeeglTQNISDPIVHLQGHTKKVGIVSFHP-SAMNVLASAGADMVV 150

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 18859301  175 KVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKD 213
Cdd:PTZ00421 151 NVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKD 189
WD40 pfam00400
WD domain, G-beta repeat;
136-178 2.55e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 2.55e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 18859301   136 GVCKYTIQddSHTEWVSCVRFSPNSSnpIIVSCGWDKMVKVWN 178
Cdd:pfam00400   1 GKLLKTLE--GHTGSVTSLAFSPDGK--LLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 190-220 5.47e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 5.47e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 18859301    190 GHTGYLNTVTVSPDGSLCASGGKDGQAMLWD 220
Cdd:smart00320  10 GHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
183-220 1.04e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 1.04e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 18859301   183 KLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWD 220
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 11-133 2.22e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 42.77  E-value: 2.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859301   11 LKGHSGWVTQIATTPQFPDMILSASRDKTIIMWKLtrdetNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLW 90
Cdd:PLN00181 571 MKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSI-----NQGVSIGTIKTKANICCVQFPSESGRSLAFGSADHKVYYY 645

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 18859301   91 DLTTGTTTR-RFVGHTKDVLSVAFsADNRQIVSGSRDKTIKLWN 133
Cdd:PLN00181 646 DLRNPKLPLcTMIGHSKTVSYVRF-VDSSTLVSSSTDNTLKLWD 688
PTZ00421 PTZ00421
coronin; Provisional
 11-131 2.70e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 42.57  E-value: 2.70e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859301   11 LKGHSGWVTQIATTPQFPDMILSASRDKTIIMWKLTRD--ETNYGIPQRALRGHSHFVSDVVI--SSDGQFALSGSwDGT 86
Cdd:PTZ00421  71 LLGQEGPIIDVAFNPFDPQKLFTASEDGTIMGWGIPEEglTQNISDPIVHLQGHTKKVGIVSFhpSAMNVLASAGA-DMV 149

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 18859301   87 LRLWDLTTGTTTRRFVGHTKDVLSVAFSADNRQIVSGSRDKTIKL 131
Cdd:PTZ00421 150 VNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNI 194
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 4-44 2.00e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 2.00e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 18859301      4 QMTVRGTLKGHSGWVTQIATTPQFpDMILSASRDKTIIMWK 44
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
PTZ00420 PTZ00420
coronin; Provisional
 11-92 2.11e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 39.55  E-value: 2.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859301   11 LKGHSGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYG---IPQRALRGHSHFVSDVVISSDGQFAL-SGSWDGT 86
Cdd:PTZ00420  70 LKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPHNDESVKeikDPQCILKGHKKKISIIDWNPMNYYIMcSSGFDSF 149


                 ....*.
gi 18859301   87 LRLWDL 92
Cdd:PTZ00420 150 VNIWDI 155
WD40 pfam00400
WD domain, G-beta repeat;
5-43 3.20e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.63  E-value: 3.20e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 18859301     5 MTVRGTLKGHSGWVTQIATTPQfPDMILSASRDKTIIMW 43
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVW 38
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 59-128 3.43e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 38.90  E-value: 3.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859301    59 LRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFV-----------------------GHTKDVLSVAFSA 115
Cdd:pfam20426 120 IRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVLRGRSSEKRSrntqtefprkdhviaetpfhilcGHDDIITCLYVSV 199

                          90
                  ....*....|...
gi 18859301   116 DNRQIVSGSRDKT 128
Cdd:pfam20426 200 ELDIVISGSKDGT 212
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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