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Conserved domains on  [gi|148230697|ref|NP_571788|]
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asporin precursor [Danio rerio]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 12183199)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
87-314 2.33e-23

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 100.39  E-value: 2.33e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148230697  87 PKDIPANTLLLDLQNNDITEIKEDDFKGLDNLYALFLLNNqiskihpKAFRNMNKLKILHLSYNLLTQMPENLP--ISVQ 164
Cdd:COG4886   67 LLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEELAnlTNLK 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148230697 165 SLRLHDNKISRLPKgAFKGMHDLNVLELSANPITNSGIDVGAFDDMATLYLRiaEAKLTAIPKDL--PSSLNELHLDYNK 242
Cdd:COG4886  140 ELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLS--NNQITDLPEPLgnLTNLEELDLSGNQ 216

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 148230697 243 IAKVeSEDFLRLKGLQRLWLDFNQIKYVENgtFAATPKVREIHLDNNKLKKIPPGLNtLKYLQVMYLHANSI 314
Cdd:COG4886  217 LTDL-PEPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLAN-LTNLKTLDLSNNQL 284
LRRNT smart00013
Leucine rich repeat N-terminal domain;
64-94 4.60e-10

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 54.25  E-value: 4.60e-10
                           10        20        30
                   ....*....|....*....|....*....|.
gi 148230697    64 DCPEGCRCSKKVLQCSDQGLTKVPKDIPANT 94
Cdd:smart00013   1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDT 31
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
87-314 2.33e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 100.39  E-value: 2.33e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148230697  87 PKDIPANTLLLDLQNNDITEIKEDDFKGLDNLYALFLLNNqiskihpKAFRNMNKLKILHLSYNLLTQMPENLP--ISVQ 164
Cdd:COG4886   67 LLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEELAnlTNLK 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148230697 165 SLRLHDNKISRLPKgAFKGMHDLNVLELSANPITNSGIDVGAFDDMATLYLRiaEAKLTAIPKDL--PSSLNELHLDYNK 242
Cdd:COG4886  140 ELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLS--NNQITDLPEPLgnLTNLEELDLSGNQ 216

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 148230697 243 IAKVeSEDFLRLKGLQRLWLDFNQIKYVENgtFAATPKVREIHLDNNKLKKIPPGLNtLKYLQVMYLHANSI 314
Cdd:COG4886  217 LTDL-PEPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLAN-LTNLKTLDLSNNQL 284
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
82-350 3.61e-17

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 83.21  E-value: 3.61e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148230697  82 GLTKVPKDIPANTLLLDLQNNDITEIKEDdFKGldNLYALFLLNNQISKIhPKAFRNMnkLKILHLSYNLLTQMPENLPI 161
Cdd:PRK15370 189 GLTTIPACIPEQITTLILDNNELKSLPEN-LQG--NIKTLYANSNQLTSI-PATLPDT--IQEMELSINRITELPERLPS 262

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148230697 162 SVQSLRLHDNKISRLPKGAFKGMHDLNVLElsanpitNSGIDVGAFDDMATLYLRIAEAKLTAIPKDLPSSLNELHLDYN 241
Cdd:PRK15370 263 ALQSLDLFHNKISCLPENLPEELRYLSVYD-------NSIRTLPAHLPSGITHLNVQSNSLTALPETLPPGLKTLEAGEN 335

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148230697 242 KIAKVESEdflRLKGLQRLWLDFNQIKYVENgtfAATPKVREIHLDNNKLKKIPPGL-NTLKYLQVMYlhaNSIgyVGVN 320
Cdd:PRK15370 336 ALTSLPAS---LPPELQVLDVSKNQITVLPE---TLPPTITTLDVSRNALTNLPENLpAALQIMQASR---NNL--VRLP 404

                        250       260       270
                 ....*....|....*....|....*....|
gi 148230697 321 DFCPSrTRAKKALYTRISLYANPVKYWEIQ 350
Cdd:PRK15370 405 ESLPH-FRGEGPQPTRIIVEYNPFSERTIQ 433
LRR_8 pfam13855
Leucine rich repeat;
97-152 3.42e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.22  E-value: 3.42e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 148230697   97 LDLQNNDITEIKEDDFKGLDNLYALFLLNNQISKIHPKAFRNMNKLKILHLSYNLL 152
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRNT smart00013
Leucine rich repeat N-terminal domain;
64-94 4.60e-10

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 54.25  E-value: 4.60e-10
                           10        20        30
                   ....*....|....*....|....*....|.
gi 148230697    64 DCPEGCRCSKKVLQCSDQGLTKVPKDIPANT 94
Cdd:smart00013   1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDT 31
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 64-91 2.65e-07

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 46.47  E-value: 2.65e-07
                          10        20
                  ....*....|....*....|....*...
gi 148230697   64 DCPEGCRCSKKVLQCSDQGLTKVPKDIP 91
Cdd:pfam01462   1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 76-199 3.37e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.55  E-value: 3.37e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148230697  76 LQCSDQGLTKVPKDIPANTLL-LDLQNNDITEIkeDDFKGLDNLYALFLLNNQISKIHPkaFRNMNKLKILHLSYNLLT- 153
Cdd:cd21340    7 LYLNDKNITKIDNLSLCKNLKvLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISv 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 148230697 154 ------------------QMPENLPI------------SVQSLRLHDNKISRLpkGAFKGMHDLNVLELSANPITN 199
Cdd:cd21340   83 veglenltnleelhienqRLPPGEKLtfdprslaalsnSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISD 156
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
87-314 2.33e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 100.39  E-value: 2.33e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148230697  87 PKDIPANTLLLDLQNNDITEIKEDDFKGLDNLYALFLLNNqiskihpKAFRNMNKLKILHLSYNLLTQMPENLP--ISVQ 164
Cdd:COG4886   67 LLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEELAnlTNLK 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148230697 165 SLRLHDNKISRLPKgAFKGMHDLNVLELSANPITNSGIDVGAFDDMATLYLRiaEAKLTAIPKDL--PSSLNELHLDYNK 242
Cdd:COG4886  140 ELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLS--NNQITDLPEPLgnLTNLEELDLSGNQ 216

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 148230697 243 IAKVeSEDFLRLKGLQRLWLDFNQIKYVENgtFAATPKVREIHLDNNKLKKIPPGLNtLKYLQVMYLHANSI 314
Cdd:COG4886  217 LTDL-PEPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLAN-LTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
97-304 5.98e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 93.46  E-value: 5.98e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148230697  97 LDLQNNDITEIkEDDFKGLDNLYALFLLNNQISKIhPKAFRNMNKLKILHLSYNLLTQMPE---NLPiSVQSLRLHDNKI 173
Cdd:COG4886  118 LDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEelgNLT-NLKELDLSNNQI 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148230697 174 SRLPKgAFKGMHDLNVLELSANPITNSGIDVGAFDDMATLYLRiaEAKLTAIP--KDLPSsLNELHLDYNKIAKVESEdf 251
Cdd:COG4886  195 TDLPE-PLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLS--NNQLTDLPelGNLTN-LEELDLSNNQLTDLPPL-- 268

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 148230697 252 LRLKGLQRLWLDFNQIKYVENGTFAATPKVREIHLDNNKLKKIPPGLNTLKYL 304
Cdd:COG4886  269 ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLT 321
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
82-350 3.61e-17

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 83.21  E-value: 3.61e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148230697  82 GLTKVPKDIPANTLLLDLQNNDITEIKEDdFKGldNLYALFLLNNQISKIhPKAFRNMnkLKILHLSYNLLTQMPENLPI 161
Cdd:PRK15370 189 GLTTIPACIPEQITTLILDNNELKSLPEN-LQG--NIKTLYANSNQLTSI-PATLPDT--IQEMELSINRITELPERLPS 262

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148230697 162 SVQSLRLHDNKISRLPKGAFKGMHDLNVLElsanpitNSGIDVGAFDDMATLYLRIAEAKLTAIPKDLPSSLNELHLDYN 241
Cdd:PRK15370 263 ALQSLDLFHNKISCLPENLPEELRYLSVYD-------NSIRTLPAHLPSGITHLNVQSNSLTALPETLPPGLKTLEAGEN 335

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148230697 242 KIAKVESEdflRLKGLQRLWLDFNQIKYVENgtfAATPKVREIHLDNNKLKKIPPGL-NTLKYLQVMYlhaNSIgyVGVN 320
Cdd:PRK15370 336 ALTSLPAS---LPPELQVLDVSKNQITVLPE---TLPPTITTLDVSRNALTNLPENLpAALQIMQASR---NNL--VRLP 404

                        250       260       270
                 ....*....|....*....|....*....|
gi 148230697 321 DFCPSrTRAKKALYTRISLYANPVKYWEIQ 350
Cdd:PRK15370 405 ESLPH-FRGEGPQPTRIIVEYNPFSERTIQ 433
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
79-314 1.25e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 80.75  E-value: 1.25e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148230697  79 SDQGLTKVPKDIPANTLLLDLQNNDITEIKEDDFKGLDNLYALFLLNNQISKIHPKAFRNMNKLKILHLSYNLLTQMPEN 158
Cdd:COG4886   35 LALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTN 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148230697 159 LpisvQSLRLHDNKISRLPKgAFKGMHDLNVLELSANPITNsgidvgafddmatlylriaeakltaIPKDLPS--SLNEL 236
Cdd:COG4886  115 L----ESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTD-------------------------LPEPLGNltNLKSL 164

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 148230697 237 HLDYNKIAKVeSEDFLRLKGLQRLWLDFNQIKYVENgTFAATPKVREIHLDNNKLKKIPPGLNTLKYLQVMYLHANSI 314
Cdd:COG4886  165 DLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL 240
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
74-289 4.17e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.21  E-value: 4.17e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148230697  74 KVLQCSDQGLTKVPKDIPANTLL--LDLQNNDITEIKEDdFKGLDNLYALFLLNNQISKIhPKAFRNMNKLKILHLSYNL 151
Cdd:COG4886  162 KSLDLSNNQLTDLPEELGNLTNLkeLDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQ 239

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148230697 152 LTQMPE--NLPiSVQSLRLHDNKISRLPKGAfkGMHDLNVLELSANPITN---SGIDVGAFDDMATLYLRIAEAKLTAIP 226
Cdd:COG4886  240 LTDLPElgNLT-NLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDlklKELELLLGLNSLLLLLLLLNLLELLIL 316

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 148230697 227 KDLPSSLNELHLDYNKIAKVESEDFLRLKGLQRLWLDFNQIKYVENGTFAATPKVREIHLDNN 289
Cdd:COG4886  317 LLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATL 379
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
60-254 2.88e-11

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 65.10  E-value: 2.88e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148230697  60 NFVTDCPEGCRCSKKVLQCSDQGLTKVPKDIPANTLLLDLQNNDITEIKEDDFKGLDNlyaLFLLNNQISKIhPKAFrNM 139
Cdd:PRK15370 251 NRITELPERLPSALQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTLPAHLPSGITH---LNVQSNSLTAL-PETL-PP 325

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148230697 140 NkLKILHLSYNLLTQMPENLPISVQSLRLHDNKISRLPKGAFKGMHDLNVlelSANPITNSGIDVGAfddmATLYLRIAE 219
Cdd:PRK15370 326 G-LKTLEAGENALTSLPASLPPELQVLDVSKNQITVLPETLPPTITTLDV---SRNALTNLPENLPA----ALQIMQASR 397

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 148230697 220 AKLTAIPKDLPSSLNE------LHLDYNKIAKVESEDFLRL 254
Cdd:PRK15370 398 NNLVRLPESLPHFRGEgpqptrIIVEYNPFSERTIQNMQRL 438
LRR_8 pfam13855
Leucine rich repeat;
97-152 3.42e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.22  E-value: 3.42e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 148230697   97 LDLQNNDITEIKEDDFKGLDNLYALFLLNNQISKIHPKAFRNMNKLKILHLSYNLL 152
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRNT smart00013
Leucine rich repeat N-terminal domain;
64-94 4.60e-10

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 54.25  E-value: 4.60e-10
                           10        20        30
                   ....*....|....*....|....*....|.
gi 148230697    64 DCPEGCRCSKKVLQCSDQGLTKVPKDIPANT 94
Cdd:smart00013   1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDT 31
LRR_8 pfam13855
Leucine rich repeat;
117-197 1.41e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 1.41e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148230697  117 NLYALFLLNNQISKIHPKAFRNMNKLKILHLSYNLLTqmpenlpisvqslrlhdnkisRLPKGAFKGMHDLNVLELSANP 196
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT---------------------TLSPGAFSGLPSLRYLDLSGNR 60


                  .
gi 148230697  197 I 197
Cdd:pfam13855  61 L 61
LRR_8 pfam13855
Leucine rich repeat;
231-291 7.23e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 7.23e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 148230697  231 SSLNELHLDYNKIAKVESEDFLRLKGLQRLWLDFNQIKYVENGTFAATPKVREIHLDNNKL 291
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 64-91 2.65e-07

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 46.47  E-value: 2.65e-07
                          10        20
                  ....*....|....*....|....*...
gi 148230697   64 DCPEGCRCSKKVLQCSDQGLTKVPKDIP 91
Cdd:pfam01462   1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 76-199 3.37e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.55  E-value: 3.37e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148230697  76 LQCSDQGLTKVPKDIPANTLL-LDLQNNDITEIkeDDFKGLDNLYALFLLNNQISKIHPkaFRNMNKLKILHLSYNLLT- 153
Cdd:cd21340    7 LYLNDKNITKIDNLSLCKNLKvLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISv 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 148230697 154 ------------------QMPENLPI------------SVQSLRLHDNKISRLpkGAFKGMHDLNVLELSANPITN 199
Cdd:cd21340   83 veglenltnleelhienqRLPPGEKLtfdprslaalsnSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISD 156
LRR_8 pfam13855
Leucine rich repeat;
162-243 2.97e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.05  E-value: 2.97e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148230697  162 SVQSLRLHDNKISRLPKGAFKGMHDLNVLELSANPITnsGIDVGAFDDMAtlylriaeakltaipkdlpsSLNELHLDYN 241
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT--TLSPGAFSGLP--------------------SLRYLDLSGN 59


                  ..
gi 148230697  242 KI 243
Cdd:pfam13855  60 RL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 76-314 4.02e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.61  E-value: 4.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148230697  76 LQCSDQGLTKvpkDIPAntLLLDLQNNDITEIKEDDFKG--------LDNLYALFLLNNQISKIHPKAFRNMNKLKILHL 147
Cdd:PLN00113 289 LDLSDNSLSG---EIPE--LVIQLQNLEILHLFSNNFTGkipvaltsLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDL 363

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148230697 148 SYNLLT-------------------------QMPENLPI--SVQSLRLHDNKIS-RLPKGaFKGMHDLNVLELSANPITn 199
Cdd:PLN00113 364 STNNLTgeipeglcssgnlfklilfsnslegEIPKSLGAcrSLRRVRLQDNSFSgELPSE-FTKLPLVYFLDISNNNLQ- 441

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148230697 200 sgidvgafddmatlylriaeAKLTAIPKDLPSsLNELHLDYNKIAKvESEDFLRLKGLQRLWLDFNQIKYVENGTFAATP 279
Cdd:PLN00113 442 --------------------GRINSRKWDMPS-LQMLSLARNKFFG-GLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLS 499

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 148230697 280 KVREIHLDNNKLK-KIPPGLNTLKYLQVMYLHANSI 314
Cdd:PLN00113 500 ELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQL 535
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 74-310 1.83e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 43.68  E-value: 1.83e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148230697  74 KVLQCSDQGLT-KVPKDIPA--NTLLLDLQNNDITEIKEDDFKGLDNLYALFLLNNQISKIHPKAFRNMNKLKILHLSYN 150
Cdd:PLN00113 335 QVLQLWSNKFSgEIPKNLGKhnNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDN 414

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148230697 151 LLT-QMPEN---LPIsVQSLRLHDNKISRLPKGAFKGMHDLNVLELSANPITNSGIDVGAFDDMATLYL---RIAEAklt 223
Cdd:PLN00113 415 SFSgELPSEftkLPL-VYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLPDSFGSKRLENLDLsrnQFSGA--- 490

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148230697 224 aIPKDLP--SSLNELHLDYNKIAKVESEDFLRLKGLQRLWLDFNQIKYVENGTFAATPKVREIHLDNNKLK-KIPPGLNT 300
Cdd:PLN00113 491 -VPRKLGslSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGN 569

                        250
                 ....*....|.
gi 148230697 301 LKYL-QVMYLH 310
Cdd:PLN00113 570 VESLvQVNISH 580
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 86-313 1.94e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 43.68  E-value: 1.94e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148230697  86 VPKDIPANTLL--LDLQNNDITEIKEDDFKGLDNLYALFLLNNQISKIHPKAFRNMNKLKILHLSYNLLT-QMPEnLPIS 162
Cdd:PLN00113 228 IPYEIGGLTSLnhLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSgEIPE-LVIQ 306

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148230697 163 VQSLR---LHDNKISRLPKGAFKGMHDLNVLELSANPITnSGI--DVGAFDDMATLYLriAEAKLTA-IPKDLPSS--LN 234
Cdd:PLN00113 307 LQNLEilhLFSNNFTGKIPVALTSLPRLQVLQLWSNKFS-GEIpkNLGKHNNLTVLDL--STNNLTGeIPEGLCSSgnLF 383

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148230697 235 ELHLDYNKIAKVESEDFLRLKGLQRLWLDFNQIKYVENGTFAATPKVREIHLDNNKLKKippGLNTLKY----LQVMYLH 310
Cdd:PLN00113 384 KLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQG---RINSRKWdmpsLQMLSLA 460


                 ...
gi 148230697 311 ANS 313
Cdd:PLN00113 461 RNK 463
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 72-314 2.75e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.91  E-value: 2.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148230697  72 SKKVLQCSDQGLT-KVPKDIPANTLLLDLQNNDITEIKEDDFKGLDNLYALFLLNNQISKIHPKAFRNMNKLKILHLSYN 150
Cdd:PLN00113 119 SLRYLNLSNNNFTgSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASN 198

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148230697 151 LLT-QMPENLPiSVQSLRL----HDNKISRLPKgAFKGMHDLNVLELSANPITnsGIDVGAFDDMATL-YLRIAEAKLTA 224
Cdd:PLN00113 199 QLVgQIPRELG-QMKSLKWiylgYNNLSGEIPY-EIGGLTSLNHLDLVYNNLT--GPIPSSLGNLKNLqYLFLYQNKLSG 274

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148230697 225 -IPKDLPSSLNELHLDY--NKIAKVESEDFLRLKGLQRLWLDFNQIKYVENGTFAATPKVREIHLDNNKLK-KIPPGLNT 300
Cdd:PLN00113 275 pIPPSIFSLQKLISLDLsdNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGK 354

                        250
                 ....*....|....
gi 148230697 301 LKYLQVMYLHANSI 314
Cdd:PLN00113 355 HNNLTVLDLSTNNL 368
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 236-314 3.02e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 41.70  E-value: 3.02e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 148230697 236 LHLDYNKIAKVEseDFLRLKGLQRLWLDFNQIKYVENgtFAATPKVREIHLDNNKLKKIPpGLNTLKYLQVMYLHANSI 314
Cdd:cd21340    7 LYLNDKNITKID--NLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNRI 80
PLN03150 PLN03150
hypothetical protein; Provisional
 97-177 4.31e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.11  E-value: 4.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148230697  97 LDLQNNDITEIKEDDFKGLDNLYALFLLNNQISKIHPKAFRNMNKLKILHLSYNLLT-QMPENLP--ISVQSLRLHDNKI 173
Cdd:PLN03150 423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNgSIPESLGqlTSLRILNLNGNSL 502


                 ....*
gi 148230697 174 S-RLP 177
Cdd:PLN03150 503 SgRVP 507
LRR_8 pfam13855
Leucine rich repeat;
256-314 9.23e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 9.23e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 148230697  256 GLQRLWLDFNQIKYVENGTFAATPKVREIHLDNNKLKKIPP----GLNTLKYLqvmYLHANSI 314
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPgafsGLPSLRYL---DLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 133-323 1.67e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.03  E-value: 1.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148230697 133 PKAFRNMNKLKILHLSYNLLTqmPENLPI--------SVQSLRLHDNKISRLPkGAFKG------MHDLNVLELSANPIT 198
Cdd:cd00116   74 LQGLTKGCGLQELDLSDNALG--PDGCGVlesllrssSLQELKLNNNGLGDRG-LRLLAkglkdlPPALEKLVLGRNRLE 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148230697 199 NSGidvgafddmatlylriaeakLTAIPKDLPS--SLNELHLDYNKI----AKVESEDFLRLKGLQRLWLDFNQIKYVEN 272
Cdd:cd00116  151 GAS--------------------CEALAKALRAnrDLKELNLANNGIgdagIRALAEGLKANCNLEVLDLNNNGLTDEGA 210

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 148230697 273 GTFAATPK----VREIHLDNNKLK-----KIPPGL-NTLKYLQVMYLHANSIGYVGVNDFC 323
Cdd:cd00116  211 SALAETLAslksLEVLNLGDNNLTdagaaALASALlSPNISLLTLSLSCNDITDDGAKDLA 271
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 123-269 3.43e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 38.88  E-value: 3.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148230697 123 LLNNQISKIHPKAFRNMNKLKILHLSYN---------LLTQMPENLpiSVQSLRLHDNKI----SRLPKGAFKGMHDLNV 189
Cdd:cd00116  148 RLEGASCEALAKALRANRDLKELNLANNgigdagiraLAEGLKANC--NLEVLDLNNNGLtdegASALAETLASLKSLEV 225

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148230697 190 LELSANPITNSGIdvgafddmatlylriaeAKLTAIPKDLPSSLNELHLDYNKIAKVESEDFLRL----KGLQRLWLDFN 265
Cdd:cd00116  226 LNLGDNNLTDAGA-----------------AALASALLSPNISLLTLSLSCNDITDDGAKDLAEVlaekESLLELDLRGN 288


                 ....
gi 148230697 266 QIKY 269
Cdd:cd00116  289 KFGE 292
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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