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Conserved domains on  [gi|19718786|ref|NP_579917|]
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cell cycle checkpoint protein RAD17 isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
rad24 TIGR00602
checkpoint protein rad24; All proteins in this family for which functions are known are ...
 13-652 0e+00

checkpoint protein rad24; All proteins in this family for which functions are known are involved in DNA damage tolerance (likely cell cycle checkpoints).This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


:

Pssm-ID: 129690 [Multi-domain]  Cd Length: 637  Bit Score: 1002.17  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718786    13 TKVTDWVDPSFDDFLECSGVSTITATSLGVNNSSHRRKNGPSTLessrFPARKRGNLSsLEQIYGLENSKEYLSENEPWV 92
Cdd:TIGR00602   1 MDVTDWVKPSFDDFLLSSLISTITKWSLSRPTSSHRRKNSPSTD----IHARKRGFLS-LEQDTGLELSSENLDGNEPWV 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718786    93 DKYKPETQHELAVHKKKIEEVETWLKAQVLERQPKQggsILLITGPPGCGKTTTLKILSKEHGIQVQEWINPVLPDFQKD 172
Cdd:TIGR00602  76 EKYKPETQHELAVHKKKIEEVETWLKAQVLENAPKR---ILLITGPSGCGKSTTIKILSKELGIQVQEWSNPTLPDFQKN 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718786   173 DFKGMFNTESSFHMFpyQSQIAVFKEFLLRATkyNKLQMLGDDLRTDKKIILVEDLPNQFYRDSHTLHEVLR-KYVRIGR 251
Cdd:TIGR00602 153 DHKVTLSLESCFSNF--QSQIEVFSEFLLRAT--NKLQMLGDDLMTDKKIILVEDLPNQFYRDTRALHEILRwKYVSIGR 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718786   252 CPLIFIISDSLSGDNNQ-RLLFP------KEIQEECSISNISFNPVAPTIMMKFLNRIVTIEANKNGGKITVPDKTSLEL 324
Cdd:TIGR00602 229 CPLVFIITESLEGDNNQrRLLFPaetimnKEILEEPRVSNISFNPIAPTIMKKFLNRIVTIEAKKNGEKIKVPKKTSVEL 308

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718786   325 LCQGCSGDIRSAINSLQFSSSKGenNLRPRKKGMSLKSDAVLSKSKRRKKPDRVFENQEVQAIGGKDVSLFLFRALGKIL 404
Cdd:TIGR00602 309 LCQGCSGDIRSAINSLQFSSSKS--GSLPIKKRMSTKSDAHASKSKIKGKHSSNNENQEIQALGGKDVSLFLFRALGKIL 386

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718786   405 YCKRASLTELDSPRLPSHLSEYERDTLLVEPEEVVEMSHMPGD-LFNLYLHQNYIDFFMEIDDIVRASEFLSFADILSGD 483
Cdd:TIGR00602 387 YCKRATLNELDSPRLPSHLSELSRDTLMVGPEEVVEMSHMPGDkTFNLYSHQNYNDFFVEFDDEVKASEFLNFADILSGD 466

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718786   484 WNTRSLLREYSTSIATRGVMHSNKARGYAHCQGGGSSFRPLHKPQWFLINKKYRENCLAAKALF--PDFCLPALCLQTQL 561
Cdd:TIGR00602 467 WNTRSLLREYSTSSARRGVMHSNKARGIAHCQGGKSSFRPLHKPQWFLISKKYRENCLAAKALFkvEDFCLPADCLQTQL 546

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718786   562 LPYLALLTIPMRNQAQISFIQDIGRLPLKRHFGRLKMEALTDREHGMIDPDSGDEAQLNGGHSAEESLGEPTQATVPETW 641
Cdd:TIGR00602 547 LPYLALDTIPMRNDAQISFIDDLGRLPLKRDFRRLKMEALTDREVGMIDPDSGDEETSFGDDPAVESDSDPSQAAGPETW 626

                         650
                  ....*....|.
gi 19718786   642 SLPLSQNSASE 652
Cdd:TIGR00602 627 SLPDSDNSLSE 637
 
Name Accession Description Interval E-value
rad24 TIGR00602
checkpoint protein rad24; All proteins in this family for which functions are known are ...
 13-652 0e+00

checkpoint protein rad24; All proteins in this family for which functions are known are involved in DNA damage tolerance (likely cell cycle checkpoints).This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129690 [Multi-domain]  Cd Length: 637  Bit Score: 1002.17  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718786    13 TKVTDWVDPSFDDFLECSGVSTITATSLGVNNSSHRRKNGPSTLessrFPARKRGNLSsLEQIYGLENSKEYLSENEPWV 92
Cdd:TIGR00602   1 MDVTDWVKPSFDDFLLSSLISTITKWSLSRPTSSHRRKNSPSTD----IHARKRGFLS-LEQDTGLELSSENLDGNEPWV 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718786    93 DKYKPETQHELAVHKKKIEEVETWLKAQVLERQPKQggsILLITGPPGCGKTTTLKILSKEHGIQVQEWINPVLPDFQKD 172
Cdd:TIGR00602  76 EKYKPETQHELAVHKKKIEEVETWLKAQVLENAPKR---ILLITGPSGCGKSTTIKILSKELGIQVQEWSNPTLPDFQKN 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718786   173 DFKGMFNTESSFHMFpyQSQIAVFKEFLLRATkyNKLQMLGDDLRTDKKIILVEDLPNQFYRDSHTLHEVLR-KYVRIGR 251
Cdd:TIGR00602 153 DHKVTLSLESCFSNF--QSQIEVFSEFLLRAT--NKLQMLGDDLMTDKKIILVEDLPNQFYRDTRALHEILRwKYVSIGR 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718786   252 CPLIFIISDSLSGDNNQ-RLLFP------KEIQEECSISNISFNPVAPTIMMKFLNRIVTIEANKNGGKITVPDKTSLEL 324
Cdd:TIGR00602 229 CPLVFIITESLEGDNNQrRLLFPaetimnKEILEEPRVSNISFNPIAPTIMKKFLNRIVTIEAKKNGEKIKVPKKTSVEL 308

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718786   325 LCQGCSGDIRSAINSLQFSSSKGenNLRPRKKGMSLKSDAVLSKSKRRKKPDRVFENQEVQAIGGKDVSLFLFRALGKIL 404
Cdd:TIGR00602 309 LCQGCSGDIRSAINSLQFSSSKS--GSLPIKKRMSTKSDAHASKSKIKGKHSSNNENQEIQALGGKDVSLFLFRALGKIL 386

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718786   405 YCKRASLTELDSPRLPSHLSEYERDTLLVEPEEVVEMSHMPGD-LFNLYLHQNYIDFFMEIDDIVRASEFLSFADILSGD 483
Cdd:TIGR00602 387 YCKRATLNELDSPRLPSHLSELSRDTLMVGPEEVVEMSHMPGDkTFNLYSHQNYNDFFVEFDDEVKASEFLNFADILSGD 466

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718786   484 WNTRSLLREYSTSIATRGVMHSNKARGYAHCQGGGSSFRPLHKPQWFLINKKYRENCLAAKALF--PDFCLPALCLQTQL 561
Cdd:TIGR00602 467 WNTRSLLREYSTSSARRGVMHSNKARGIAHCQGGKSSFRPLHKPQWFLISKKYRENCLAAKALFkvEDFCLPADCLQTQL 546

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718786   562 LPYLALLTIPMRNQAQISFIQDIGRLPLKRHFGRLKMEALTDREHGMIDPDSGDEAQLNGGHSAEESLGEPTQATVPETW 641
Cdd:TIGR00602 547 LPYLALDTIPMRNDAQISFIDDLGRLPLKRDFRRLKMEALTDREVGMIDPDSGDEETSFGDDPAVESDSDPSQAAGPETW 626

                         650
                  ....*....|.
gi 19718786   642 SLPLSQNSASE 652
Cdd:TIGR00602 627 SLPDSDNSLSE 637
Rad17 pfam03215
Rad17 P-loop domain;
83-270 9.89e-93

Rad17 P-loop domain;


Pssm-ID: 367398 [Multi-domain]  Cd Length: 186  Bit Score: 285.31  E-value: 9.89e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718786    83 EYLSENEPWVDKYKPETQHELAVHKKKIEEVETWLKAQVLERQPKqggSILLITGPPGCGKTTTLKILSKEHGIQVQEWI 162
Cdd:pfam03215   1 INDDGGEQWYEKYKPNCLEQLAVHKRKIKDVQEWLDAMFLENAKH---RILLISGPSGCGKSTVIKELSKELGPKYREWS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718786   163 NPVL---PDFQKDDFKGMFNTESSFhmfpyQSQIAVFKEFLLRATKYNKLQMLGDDLRTDKKIILVEDLPNQFYRDSHTL 239
Cdd:pfam03215  78 NPTSfrsPPNQVTDFRGDCIVNSRF-----LSQMESFSEFELKGARYLVMQKRGKNAQGNKKLILIEDLPNVFHIDTRRF 152

                         170       180       190
                  ....*....|....*....|....*....|....
gi 19718786   240 HEVLRKYVRIGRC-PLIFIIS--DSLSGDNNQRL 270
Cdd:pfam03215 153 QQVIRQWLYSSEPlPLIICITecEILEGDNNQRK 186
PRK04195 PRK04195
replication factor C large subunit; Provisional
 90-511 3.10e-19

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 91.14  E-value: 3.10e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718786   90 PWVDKYKPETQHELAVHKKKIEEVETWLKAQvLERQPKQGgsiLLITGPPGCGKTTTLKILSKEHGIQVQEwINPvlPDF 169
Cdd:PRK04195   3 PWVEKYRPKTLSDVVGNEKAKEQLREWIESW-LKGKPKKA---LLLYGPPGVGKTSLAHALANDYGWEVIE-LNA--SDQ 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718786  170 QKDDfkgmfntessfhmfpyqsqiaVFKEFLLRATKYNKLqmlgddLRTDKKIILVEDLPNQFYR-DSHTLHEVLrKYVR 248
Cdd:PRK04195  76 RTAD---------------------VIERVAGEAATSGSL------FGARRKLILLDEVDGIHGNeDRGGARAIL-ELIK 127

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718786  249 IGRCPLIFIISDSLSgdnnqrlLFPKEIQEECSIsnISFNPVAPTIMMKFLNRIVTIEanknggKITVPDKTsLELLCQG 328
Cdd:PRK04195 128 KAKQPIILTANDPYD-------PSLRELRNACLM--IEFKRLSTRSIVPVLKRICRKE------GIECDDEA-LKEIAER 191

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718786  329 CSGDIRSAINSLQfSSSKGENNLrprkkgmslksdavlskskrrkkpdrvfENQEVQAIGGKDVSLFLFRALGKIL---Y 405
Cdd:PRK04195 192 SGGDLRSAINDLQ-AIAEGYGKL----------------------------TLEDVKTLGRRDREESIFDALDAVFkarN 242

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718786  406 CKRA--SLTELDsprlpshlseyerdtllVEPEEVVEmshmpgdlfnlYLHQN----YIDffmeIDDIVRASEFLSFADI 479
Cdd:PRK04195 243 ADQAleASYDVD-----------------EDPDDLIE-----------WIDENipkeYDD----PEDIARAYDALSRADI 290

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|
gi 19718786  480 LSG------DWntrSLLReYSTSIATRGV--MHSNKARGY 511
Cdd:PRK04195 291 FLGrvkrtqNY---DLWR-YASDLMTAGValAKEKKKRGF 326
HLD_clamp_RarA cd18139
helical lid domain of recombination factor protein RarA; Recombination factor RarA ...
 292-354 3.48e-09

helical lid domain of recombination factor protein RarA; Recombination factor RarA (Replication associated recombination gene/protein A, also known as MgsA (Maintenance of genome stability A) or Mgs1 in yeast and WRNIP1 in mammals) is a member of the clamp-loader clade of the AAA+ superfamily. It functions as a tetramer. RarA co-localize with the replication fork throughout the cell cycle and may play a role in the rescue of stalled replication forks.


Pssm-ID: 350841 [Multi-domain]  Cd Length: 75  Bit Score: 53.79  E-value: 3.48e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19718786 292 PTIMMKFLNRIVTIEANKNGGKITVPDKtSLELLCQGCSGDIRSAINSLQFSSSKGENNLRPR 354
Cdd:cd18139   3 EEDLEKLLKRALEDKERGGDRKVTIDDE-ALELLAEAADGDARSALNLLELAVLSAEEDGGIV 64
Kti12 COG4088
tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) ...
 130-200 7.18e-07

tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) [Translation, ribosomal structure and biogenesis, Defense mechanisms];


Pssm-ID: 443264 [Multi-domain]  Cd Length: 179  Bit Score: 49.73  E-value: 7.18e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19718786 130 GSILLITGPPGCGKTTTLKILSKEHGiqVQEWINPVLPdfqKDDFKGMFNTESsfhmFPYQSQIAVFKEFL 200
Cdd:COG4088   4 PMLLILTGPPGSGKTTFAKALAQRLY--AEGIAVALLH---SDDFRRFLVNES----FPKETYEEVVEDVR 65
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 130-153 1.99e-04

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 42.36  E-value: 1.99e-04
                           10        20
                   ....*....|....*....|....
gi 19718786    130 GSILLITGPPGCGKTTTLKILSKE 153
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARE 25
 
Name Accession Description Interval E-value
rad24 TIGR00602
checkpoint protein rad24; All proteins in this family for which functions are known are ...
 13-652 0e+00

checkpoint protein rad24; All proteins in this family for which functions are known are involved in DNA damage tolerance (likely cell cycle checkpoints).This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129690 [Multi-domain]  Cd Length: 637  Bit Score: 1002.17  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718786    13 TKVTDWVDPSFDDFLECSGVSTITATSLGVNNSSHRRKNGPSTLessrFPARKRGNLSsLEQIYGLENSKEYLSENEPWV 92
Cdd:TIGR00602   1 MDVTDWVKPSFDDFLLSSLISTITKWSLSRPTSSHRRKNSPSTD----IHARKRGFLS-LEQDTGLELSSENLDGNEPWV 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718786    93 DKYKPETQHELAVHKKKIEEVETWLKAQVLERQPKQggsILLITGPPGCGKTTTLKILSKEHGIQVQEWINPVLPDFQKD 172
Cdd:TIGR00602  76 EKYKPETQHELAVHKKKIEEVETWLKAQVLENAPKR---ILLITGPSGCGKSTTIKILSKELGIQVQEWSNPTLPDFQKN 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718786   173 DFKGMFNTESSFHMFpyQSQIAVFKEFLLRATkyNKLQMLGDDLRTDKKIILVEDLPNQFYRDSHTLHEVLR-KYVRIGR 251
Cdd:TIGR00602 153 DHKVTLSLESCFSNF--QSQIEVFSEFLLRAT--NKLQMLGDDLMTDKKIILVEDLPNQFYRDTRALHEILRwKYVSIGR 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718786   252 CPLIFIISDSLSGDNNQ-RLLFP------KEIQEECSISNISFNPVAPTIMMKFLNRIVTIEANKNGGKITVPDKTSLEL 324
Cdd:TIGR00602 229 CPLVFIITESLEGDNNQrRLLFPaetimnKEILEEPRVSNISFNPIAPTIMKKFLNRIVTIEAKKNGEKIKVPKKTSVEL 308

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718786   325 LCQGCSGDIRSAINSLQFSSSKGenNLRPRKKGMSLKSDAVLSKSKRRKKPDRVFENQEVQAIGGKDVSLFLFRALGKIL 404
Cdd:TIGR00602 309 LCQGCSGDIRSAINSLQFSSSKS--GSLPIKKRMSTKSDAHASKSKIKGKHSSNNENQEIQALGGKDVSLFLFRALGKIL 386

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718786   405 YCKRASLTELDSPRLPSHLSEYERDTLLVEPEEVVEMSHMPGD-LFNLYLHQNYIDFFMEIDDIVRASEFLSFADILSGD 483
Cdd:TIGR00602 387 YCKRATLNELDSPRLPSHLSELSRDTLMVGPEEVVEMSHMPGDkTFNLYSHQNYNDFFVEFDDEVKASEFLNFADILSGD 466

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718786   484 WNTRSLLREYSTSIATRGVMHSNKARGYAHCQGGGSSFRPLHKPQWFLINKKYRENCLAAKALF--PDFCLPALCLQTQL 561
Cdd:TIGR00602 467 WNTRSLLREYSTSSARRGVMHSNKARGIAHCQGGKSSFRPLHKPQWFLISKKYRENCLAAKALFkvEDFCLPADCLQTQL 546

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718786   562 LPYLALLTIPMRNQAQISFIQDIGRLPLKRHFGRLKMEALTDREHGMIDPDSGDEAQLNGGHSAEESLGEPTQATVPETW 641
Cdd:TIGR00602 547 LPYLALDTIPMRNDAQISFIDDLGRLPLKRDFRRLKMEALTDREVGMIDPDSGDEETSFGDDPAVESDSDPSQAAGPETW 626

                         650
                  ....*....|.
gi 19718786   642 SLPLSQNSASE 652
Cdd:TIGR00602 627 SLPDSDNSLSE 637
Rad17 pfam03215
Rad17 P-loop domain;
83-270 9.89e-93

Rad17 P-loop domain;


Pssm-ID: 367398 [Multi-domain]  Cd Length: 186  Bit Score: 285.31  E-value: 9.89e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718786    83 EYLSENEPWVDKYKPETQHELAVHKKKIEEVETWLKAQVLERQPKqggSILLITGPPGCGKTTTLKILSKEHGIQVQEWI 162
Cdd:pfam03215   1 INDDGGEQWYEKYKPNCLEQLAVHKRKIKDVQEWLDAMFLENAKH---RILLISGPSGCGKSTVIKELSKELGPKYREWS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718786   163 NPVL---PDFQKDDFKGMFNTESSFhmfpyQSQIAVFKEFLLRATKYNKLQMLGDDLRTDKKIILVEDLPNQFYRDSHTL 239
Cdd:pfam03215  78 NPTSfrsPPNQVTDFRGDCIVNSRF-----LSQMESFSEFELKGARYLVMQKRGKNAQGNKKLILIEDLPNVFHIDTRRF 152

                         170       180       190
                  ....*....|....*....|....*....|....
gi 19718786   240 HEVLRKYVRIGRC-PLIFIIS--DSLSGDNNQRL 270
Cdd:pfam03215 153 QQVIRQWLYSSEPlPLIICITecEILEGDNNQRK 186
PRK04195 PRK04195
replication factor C large subunit; Provisional
 90-511 3.10e-19

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 91.14  E-value: 3.10e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718786   90 PWVDKYKPETQHELAVHKKKIEEVETWLKAQvLERQPKQGgsiLLITGPPGCGKTTTLKILSKEHGIQVQEwINPvlPDF 169
Cdd:PRK04195   3 PWVEKYRPKTLSDVVGNEKAKEQLREWIESW-LKGKPKKA---LLLYGPPGVGKTSLAHALANDYGWEVIE-LNA--SDQ 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718786  170 QKDDfkgmfntessfhmfpyqsqiaVFKEFLLRATKYNKLqmlgddLRTDKKIILVEDLPNQFYR-DSHTLHEVLrKYVR 248
Cdd:PRK04195  76 RTAD---------------------VIERVAGEAATSGSL------FGARRKLILLDEVDGIHGNeDRGGARAIL-ELIK 127

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718786  249 IGRCPLIFIISDSLSgdnnqrlLFPKEIQEECSIsnISFNPVAPTIMMKFLNRIVTIEanknggKITVPDKTsLELLCQG 328
Cdd:PRK04195 128 KAKQPIILTANDPYD-------PSLRELRNACLM--IEFKRLSTRSIVPVLKRICRKE------GIECDDEA-LKEIAER 191

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718786  329 CSGDIRSAINSLQfSSSKGENNLrprkkgmslksdavlskskrrkkpdrvfENQEVQAIGGKDVSLFLFRALGKIL---Y 405
Cdd:PRK04195 192 SGGDLRSAINDLQ-AIAEGYGKL----------------------------TLEDVKTLGRRDREESIFDALDAVFkarN 242

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718786  406 CKRA--SLTELDsprlpshlseyerdtllVEPEEVVEmshmpgdlfnlYLHQN----YIDffmeIDDIVRASEFLSFADI 479
Cdd:PRK04195 243 ADQAleASYDVD-----------------EDPDDLIE-----------WIDENipkeYDD----PEDIARAYDALSRADI 290

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|
gi 19718786  480 LSG------DWntrSLLReYSTSIATRGV--MHSNKARGY 511
Cdd:PRK04195 291 FLGrvkrtqNY---DLWR-YASDLMTAGValAKEKKKRGF 326
HLD_clamp_RarA cd18139
helical lid domain of recombination factor protein RarA; Recombination factor RarA ...
 292-354 3.48e-09

helical lid domain of recombination factor protein RarA; Recombination factor RarA (Replication associated recombination gene/protein A, also known as MgsA (Maintenance of genome stability A) or Mgs1 in yeast and WRNIP1 in mammals) is a member of the clamp-loader clade of the AAA+ superfamily. It functions as a tetramer. RarA co-localize with the replication fork throughout the cell cycle and may play a role in the rescue of stalled replication forks.


Pssm-ID: 350841 [Multi-domain]  Cd Length: 75  Bit Score: 53.79  E-value: 3.48e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19718786 292 PTIMMKFLNRIVTIEANKNGGKITVPDKtSLELLCQGCSGDIRSAINSLQFSSSKGENNLRPR 354
Cdd:cd18139   3 EEDLEKLLKRALEDKERGGDRKVTIDDE-ALELLAEAADGDARSALNLLELAVLSAEEDGGIV 64
PRK12402 PRK12402
replication factor C small subunit 2; Reviewed
 91-349 6.66e-07

replication factor C small subunit 2; Reviewed


Pssm-ID: 237090 [Multi-domain]  Cd Length: 337  Bit Score: 51.91  E-value: 6.66e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718786   91 WVDKYKPETQHELAVHkkkiEEVETWLKAQVLERQPKQggsiLLITGPPGCGKTTTLKILSKE-HGiqvQEWINPvLPDF 169
Cdd:PRK12402   5 WTEKYRPALLEDILGQ----DEVVERLSRAVDSPNLPH----LLVQGPPGSGKTAAVRALARElYG---DPWENN-FTEF 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718786  170 QKDDFKGMFNTESS----FHMF------PYQSQIAVFKEFLLRATKYNKLQmlgddlrTDKKIILV---EDLPNQFyrdS 236
Cdd:PRK12402  73 NVADFFDQGKKYLVedprFAHFlgtdkrIRSSKIDNFKHVLKEYASYRPLS-------ADYKTILLdnaEALREDA---Q 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718786  237 HTLHEVLRKYVRIGRcpliFIISDSlsgdNNQRLLFPkeIQEECsiSNISFNPVAPTIMMKFLNRIVTIEanknggKITV 316
Cdd:PRK12402 143 QALRRIMEQYSRTCR----FIIATR----QPSKLIPP--IRSRC--LPLFFRAPTDDELVDVLESIAEAE------GVDY 204

                        250       260       270
                 ....*....|....*....|....*....|...
gi 19718786  317 PDKtSLELLCQGCSGDIRSAINSLQFSSSKGEN 349
Cdd:PRK12402 205 DDD-GLELIAYYAGGDLRKAILTLQTAALAAGE 236
Kti12 COG4088
tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) ...
 130-200 7.18e-07

tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) [Translation, ribosomal structure and biogenesis, Defense mechanisms];


Pssm-ID: 443264 [Multi-domain]  Cd Length: 179  Bit Score: 49.73  E-value: 7.18e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19718786 130 GSILLITGPPGCGKTTTLKILSKEHGiqVQEWINPVLPdfqKDDFKGMFNTESsfhmFPYQSQIAVFKEFL 200
Cdd:COG4088   4 PMLLILTGPPGSGKTTFAKALAQRLY--AEGIAVALLH---SDDFRRFLVNES----FPKETYEEVVEDVR 65
HLD_clamp_RFC cd18140
helical lid domain of replication factor C subunit; Replication factor C (RFC) is five-protein ...
 295-349 1.21e-05

helical lid domain of replication factor C subunit; Replication factor C (RFC) is five-protein clamp loader complex that forms a stable ATP-dependent complex with the sliding clamp, PCNA, which binds specifically to primed DNA. RFC subunits belong to the clamp loader clade of the AAA+ superfamily.


Pssm-ID: 350842 [Multi-domain]  Cd Length: 63  Bit Score: 43.29  E-value: 1.21e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 19718786 295 MMKFLNRIVTIEanknggKITVPDKtSLELLCQGCSGDIRSAINSLQFSSSKGEN 349
Cdd:cd18140   6 IVKRLREICKKE------GVKIDEE-ALEAIAEKSEGDMRKAINDLQAAAAGGGV 53
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 107-153 6.37e-05

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 45.67  E-value: 6.37e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 19718786 107 KKKIEEVETWLKAQVLERQ---PKQGGSILLiTGPPGCGKTTTLKILSKE 153
Cdd:COG0464 166 KEELRELVALPLKRPELREeygLPPPRGLLL-YGPPGTGKTLLARALAGE 214
dNK pfam01712
Deoxynucleoside kinase; This family consists of various deoxynucleoside kinases cytidine EC:2. ...
 135-193 1.02e-04

Deoxynucleoside kinase; This family consists of various deoxynucleoside kinases cytidine EC:2.7.1.74, guanosine EC:2.7.1.113, adenosine EC:2.7.1.76 and thymidine kinase EC:2.7.1.21 (which also phosphorylates deoxyuridine and deoxycytosine.) These enzymes catalyze the production of deoxynucleotide 5'-monophosphate from a deoxynucleoside. Using ATP and yielding ADP in the process.


Pssm-ID: 396326  Cd Length: 201  Bit Score: 43.85  E-value: 1.02e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 19718786   135 ITGPPGCGKTTTLKILSKEHGIQ-----VQEWINPVLPDFQKdDFKG---MFNTESSFHMFPYQSQI 193
Cdd:pfam01712   3 IEGNIGAGKSTLTKILSKRLGFKvfeepVDRWTNPYLDKFYK-DPSRwsfALQTYFLNSRFKQQLEA 68
AAA_18 pfam13238
AAA domain;
134-235 1.11e-04

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 42.42  E-value: 1.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718786   134 LITGPPGCGKTTTLKILSKEHGIQvqewinpvlpDFQKDDFKGMFNTESSFHmfpyqsQIAVFKEFLLRATKYNKLQMLG 213
Cdd:pfam13238   2 LITGTPGVGKTTLAKELSKRLGFG----------DNVRDLALENGLVLGDDP------ETRESKRLDEDKLDRLLDLLEE 65

                          90       100
                  ....*....|....*....|..
gi 19718786   214 DDLRTDKKIILVEDLPNQFYRD 235
Cdd:pfam13238  66 NAALEEGGNLIIDGHLAELEPE 87
rfc PRK00440
replication factor C small subunit; Reviewed
 87-349 1.94e-04

replication factor C small subunit; Reviewed


Pssm-ID: 234763 [Multi-domain]  Cd Length: 319  Bit Score: 44.09  E-value: 1.94e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718786   87 ENEPWVDKYKPETQHELAVHkkkiEEVETWLKAQVLERQ-PKqggsiLLITGPPGCGKTTTLKILSKEhgiqvqewinpV 165
Cdd:PRK00440   3 MEEIWVEKYRPRTLDEIVGQ----EEIVERLKSYVKEKNmPH-----LLFAGPPGTGKTTAALALARE-----------L 62

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718786  166 LPDFQKDDFKGMfNTESsfhmfpyQSQIAV----FKEFLlratkynKLQMLGDdlrTDKKIILVeDLPNQFYRDS-HTLH 240
Cdd:PRK00440  63 YGEDWRENFLEL-NASD-------ERGIDVirnkIKEFA-------RTAPVGG---APFKIIFL-DEADNLTSDAqQALR 123

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718786  241 EVLRKYVRIGRcpliFIISDSLSgdnnQRLLFPkeIQEECSIsnISFNPVAPTIMMKFLNRIVTIEanknggKITVPDKt 320
Cdd:PRK00440 124 RTMEMYSQNTR----FILSCNYS----SKIIDP--IQSRCAV--FRFSPLKKEAVAERLRYIAENE------GIEITDD- 184

                        250       260
                 ....*....|....*....|....*....
gi 19718786  321 SLELLCQGCSGDIRSAINSLQFSSSKGEN 349
Cdd:PRK00440 185 ALEAIYYVSEGDMRKAINALQAAAATGKE 213
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 130-153 1.99e-04

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 42.36  E-value: 1.99e-04
                           10        20
                   ....*....|....*....|....
gi 19718786    130 GSILLITGPPGCGKTTTLKILSKE 153
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARE 25
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 117-153 2.77e-04

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 41.75  E-value: 2.77e-04
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 19718786 117 LKAQVLERQPKQGGSILLITGPPGCGKTTTLKILSKE 153
Cdd:cd00009   6 AIEALREALELPPPKNLLLYGPPGTGKTTLARAIANE 42
PLN03025 PLN03025
replication factor C subunit; Provisional
 90-153 4.71e-04

replication factor C subunit; Provisional


Pssm-ID: 178596 [Multi-domain]  Cd Length: 319  Bit Score: 42.79  E-value: 4.71e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19718786   90 PWVDKYKPETQHELAVHKKKIEevetwlKAQVLERqpkqGGSI--LLITGPPGCGKTTTLKILSKE 153
Cdd:PLN03025   2 PWVEKYRPTKLDDIVGNEDAVS------RLQVIAR----DGNMpnLILSGPPGTGKTTSILALAHE 57
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 133-158 1.22e-03

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 39.50  E-value: 1.22e-03
                          10        20
                  ....*....|....*....|....*.
gi 19718786   133 LLITGPPGCGKTTTLKILSKEHGIQV 158
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPF 26
Fap7 COG1936
Broad-specificity NMP kinase [Nucleotide transport and metabolism];
132-158 1.72e-03

Broad-specificity NMP kinase [Nucleotide transport and metabolism];


Pssm-ID: 441539 [Multi-domain]  Cd Length: 173  Bit Score: 39.80  E-value: 1.72e-03
                        10        20
                ....*....|....*....|....*..
gi 19718786 132 ILLITGPPGCGKTTTLKILSKEHGIQV 158
Cdd:COG1936   2 RIAITGTPGTGKTTVAKLLAERLGLEV 28
AAA_28 pfam13521
AAA domain;
135-158 2.29e-03

AAA domain;


Pssm-ID: 433278 [Multi-domain]  Cd Length: 164  Bit Score: 39.17  E-value: 2.29e-03
                          10        20
                  ....*....|....*....|....
gi 19718786   135 ITGPPGCGKTTTLKILSKEHGIQV 158
Cdd:pfam13521   4 ITGGPSTGKTTLAEALAARFGYPV 27
ABC_ATPase cd00267
ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large ...
 130-151 2.41e-03

ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide-binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.


Pssm-ID: 213179 [Multi-domain]  Cd Length: 157  Bit Score: 39.15  E-value: 2.41e-03
                        10        20
                ....*....|....*....|..
gi 19718786 130 GSILLITGPPGCGKTTTLKILS 151
Cdd:cd00267  25 GEIVALVGPNGSGKSTLLRAIA 46
DEXSc_RecD-like cd17933
DEXS-box helicase domain of RecD and similar proteins; RecD is a member of the RecBCD (EC 3.1. ...
 129-158 2.71e-03

DEXS-box helicase domain of RecD and similar proteins; RecD is a member of the RecBCD (EC 3.1.11.5, Exonuclease V) complex. It is the alpha chain of the complex and functions as a 3'-5' helicase. The RecBCD enzyme is both a helicase that unwinds, or separates the strands of DNA, and a nuclease that makes single-stranded nicks in DNA. RecD is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350691 [Multi-domain]  Cd Length: 155  Bit Score: 39.07  E-value: 2.71e-03
                        10        20        30
                ....*....|....*....|....*....|...
gi 19718786 129 GGSILLITGPPGCGKTTTLK---ILSKEHGIQV 158
Cdd:cd17933  11 RNRVSVLTGGAGTGKTTTLKallAALEAEGKRV 43
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 103-158 3.13e-03

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 38.80  E-value: 3.13e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 19718786 103 LAVHKKKIEEVETWLKAQVLERQPKQGgsILLItGPPGCGKTTTLKILSKEHGIQV 158
Cdd:cd19481   2 KASLREAVEAPRRGSRLRRYGLGLPKG--ILLY-GPPGTGKTLLAKALAGELGLPL 54
44 PHA02544
clamp loader, small subunit; Provisional
 80-158 3.72e-03

clamp loader, small subunit; Provisional


Pssm-ID: 222866 [Multi-domain]  Cd Length: 316  Bit Score: 39.97  E-value: 3.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718786   80 NSKEYLsenepWVDKYKPETQHE--LAVHKKKIeevetwLKAQVlerqpKQGG--SILLITGPPGCGKTTTLKILSKEHG 155
Cdd:PHA02544   5 NPNEFM-----WEQKYRPSTIDEciLPAADKET------FKSIV-----KKGRipNMLLHSPSPGTGKTTVAKALCNEVG 68


                 ...
gi 19718786  156 IQV 158
Cdd:PHA02544  69 AEV 71
PRK04182 PRK04182
cytidylate kinase; Provisional
 132-156 3.89e-03

cytidylate kinase; Provisional


Pssm-ID: 235244 [Multi-domain]  Cd Length: 180  Bit Score: 39.02  E-value: 3.89e-03
                         10        20
                 ....*....|....*....|....*
gi 19718786  132 ILLITGPPGCGKTTTLKILSKEHGI 156
Cdd:PRK04182   2 IITISGPPGSGKTTVARLLAEKLGL 26
AAA_22 pfam13401
AAA domain;
127-157 4.15e-03

AAA domain;


Pssm-ID: 379165 [Multi-domain]  Cd Length: 129  Bit Score: 37.71  E-value: 4.15e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 19718786   127 KQGGSILLITGPPGCGKTTTLKILSKEHGIQ 157
Cdd:pfam13401   2 RFGAGILVLTGESGTGKTTLLRRLLEQLPEV 32
AAA_17 pfam13207
AAA domain;
136-158 4.39e-03

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 37.99  E-value: 4.39e-03
                          10        20
                  ....*....|....*....|...
gi 19718786   136 TGPPGCGKTTTLKILSKEHGIQV 158
Cdd:pfam13207   1 TGVPGSGKTTQLKKLAEKLGFPH 23
ABC_tran pfam00005
ABC transporter; ABC transporters for a large family of proteins responsible for translocation ...
 130-154 4.51e-03

ABC transporter; ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are composed of two copies of this domain and two copies of a transmembrane domain pfam00664. These four domains may belong to a single polypeptide or belong in different polypeptide chains.


Pssm-ID: 394964 [Multi-domain]  Cd Length: 150  Bit Score: 38.01  E-value: 4.51e-03
                          10        20
                  ....*....|....*....|....*
gi 19718786   130 GSILLITGPPGCGKTTTLKILSKEH 154
Cdd:pfam00005  11 GEILALVGPNGAGKSTLLKLIAGLL 35
PulE COG2804
Type II secretory pathway ATPase GspE/PulE or T4P pilus assembly pathway ATPase PilB [Cell ...
 124-164 4.76e-03

Type II secretory pathway ATPase GspE/PulE or T4P pilus assembly pathway ATPase PilB [Cell motility, Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 442055 [Multi-domain]  Cd Length: 561  Bit Score: 40.18  E-value: 4.76e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19718786 124 RQPkQGgsILLITGPPGCGKTTTL------------KILSKE-------HGI-QVQewINP 164
Cdd:COG2804 310 RRP-HG--IILVTGPTGSGKTTTLyaalnelntperNIITVEdpveyqlPGInQVQ--VNP 365
ABCD_peroxisomal_ALDP cd03223
ATP-binding cassette domain of peroxisomal transporter, subfamily D; Peroxisomal ATP-binding ...
 127-151 6.98e-03

ATP-binding cassette domain of peroxisomal transporter, subfamily D; Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome. The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed during fatty acid beta-oxidation. To communicate with the cytoplasm and mitochondria, peroxisomes need dedicated proteins to transport such hydrophilic molecules across their membranes. X-linked adrenoleukodystrophy (X-ALD) is caused by mutations in the ALD gene, which encodes ALDP (adrenoleukodystrophy protein ), a peroxisomal integral membrane protein that is a member of the ATP-binding cassette (ABC) transporter protein family. The disease is characterized by a striking and unpredictable variation in phenotypic expression. Phenotypes include the rapidly progressive childhood cerebral form (CCALD), the milder adult form, adrenomyeloneuropathy (AMN), and variants without neurologic involvement (i.e. asymptomatic).


Pssm-ID: 213190 [Multi-domain]  Cd Length: 166  Bit Score: 37.90  E-value: 6.98e-03
                        10        20
                ....*....|....*....|....*
gi 19718786 127 KQGGSiLLITGPPGCGKTTTLKILS 151
Cdd:cd03223  25 KPGDR-LLITGPSGTGKSSLFRALA 48
PRK10247 PRK10247
putative ABC transporter ATP-binding protein YbbL; Provisional
 128-151 7.48e-03

putative ABC transporter ATP-binding protein YbbL; Provisional


Pssm-ID: 182331 [Multi-domain]  Cd Length: 225  Bit Score: 38.54  E-value: 7.48e-03
                         10        20
                 ....*....|....*....|....
gi 19718786  128 QGGSILLITGPPGCGKTTTLKILS 151
Cdd:PRK10247  31 RAGEFKLITGPSGCGKSTLLKIVA 54
AAA_16 pfam13191
AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the ...
 119-260 8.37e-03

AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.


Pssm-ID: 433025 [Multi-domain]  Cd Length: 167  Bit Score: 37.87  E-value: 8.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19718786   119 AQVLERQPKQGGSILLITGPPGCGKTTTLKILSKEHGIQvqewinpvlpdfqkddfKGMFNTESSFHMFPYQSQIAVFKE 198
Cdd:pfam13191  13 LDALDRVRSGRPPSVLLTGEAGTGKTTLLRELLRALERD-----------------GGYFLRGKCDENLPYSPLLEALTR 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19718786   199 FLLRATKYNKLQMLGDDLRTDKKIILVEDLPNQFYRDSHTLHEVLRKYVRIGRC---PLIFIISD 260
Cdd:pfam13191  76 EGLLRQLLDELESSLLEAWRAALLEALAPVPELPGDLAERLLDLLLRLLDLLARgerPLVLVLDD 140
ExeA COG3267
Type II secretory pathway ATPase component GspA/ExeA/MshM [Intracellular trafficking, ...
 128-150 9.29e-03

Type II secretory pathway ATPase component GspA/ExeA/MshM [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 442498 [Multi-domain]  Cd Length: 261  Bit Score: 38.62  E-value: 9.29e-03
                        10        20
                ....*....|....*....|...
gi 19718786 128 QGGSILLITGPPGCGKTTTLKIL 150
Cdd:COG3267  41 QGGGFVVLTGEVGTGKTTLLRRL 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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