NCBI Conserved Domain Search

Conserved domains on [gi|19527284|ref|NP_598827|]

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aldo-keto reductase family 1 member C18 isoform 1 [Mus musculus]

Protein Classification

aldo/keto reductase( domain architecture ID 14442631)

aldo/keto reductase is a soluble NAD(P)(H) oxidoreductase that catalyzes the reduction of aldehydes and ketones to their corresponding primary and secondary alcohols

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

AKR_AKR1C1-35

cd19108

AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) ...

6-308

0e+00

AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) includes AKR1C1 (20-alpha-hydroxysteroid dehydrogenase, also known as 20alpha-HSD), AKR1C2 (3alpha-HSD type 3), AKR1C3 (17beta-HSD type 5), and AKR1C4 (3alpha-HSD type 1) from Homo sapiens; AKR1C5 (20alpha-HSD, also known as prostaglandin-E(2) 9-reductase) from Rattus norvegicus (ovary); AKR1C6 (estradiol 17beta-HSD type 5) from Mus musculus; AKR1C7 (prostaglandin F synthase 1 or PGF1) from Bos taurus (lung); AKR1C8 (20alpha-HSD) from Rattus norvegicus (ovary); AKR1C9 (3alpha-HSD) from Rattus norvegicus (liver); AKR1C10a (Rho crystallin) from Rana temporaria and AKR1C10b (Rho crystallin) from Rana catesbeina; AKR1C11 (prostaglandin F synthase 2 or PGF2) from Bos taurus (liver); AKR1C12 (aldo-keto reductase or AKR), AKR1C13 (interleukin-3-regulated AKR), and AKR1C14 (3alpha-HSD) from Mus musculus; AKR1C15 (NADPH-dependent reductase), AKR1C16 (NAD+-preferring 3alpha/17beta/20alpha-HSD), and AKR1C17 (NAD+-dependent 3alpha-HSD) from Rattus norvegicus; AKR1C18 (20alpha-HSD), AKR1C19 (3-hydroxybutyrate dehydrogenase or 3HB dehydrogenase), AKR1C20 (3alpha(17beta)-HSD), AKR1C21 (3(17)alpha-HSD), AKR1C22 (dihydrodiol dehydrogenase or DD) from Mus musculus; AKR1C23 (20alpha-HSD) from Equus caballus; AKR1C24 (NAD+-dependent 17beta-HSD) from Rattus norvegicus; AKR1C25 (3(20)alpha-HSD) from Macaca fuscata; AKR1C26 (identical to morphine 6-dehydrogenase or M6DH, acts as NAD(+)-dependent 3alpha/17beta-HSD), AKR1C27/AKR1C28 (NAD(+)-dependent 3alpha/17beta-HSDs), AKR1C29 (identical to 3-hydroxyhexobarbital dehydrogenase or 3HBD, acts as NADPH-preferring reductase with 3alpha/3beta/17beta/20alpha-HSD activity), AKR1C30 (identical to naloxone reductase type 1 and acts as 17beta-HSD), AKR1C31 (3alpha/17beta/20alpha-HSD), AKR1C32 (identical to loxoprofen reductase and acts as 3alpha/20alpha-HSD), and AKR1C33 (identical to naloxone reductase type 2 and mainly acts as 3alpha-HSD) from Oryctolagus cuniculus; AKR1C34 (NAD+-dependent morphine 6-dehydrogenase or M6DH with 3beta/17beta/20alpha-HSD activity) and AKR1C35 (NAD+-dependent dehydrogenase with 3(17)beta-HSD activity) from Mesocricetus auratus.

Pssm-ID: 381334 [Multi-domain] Cd Length: 303 Bit Score: 676.26 E-value: 0e+00

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284   6 QKIELNDGHSIPVLGFGTYATEEHLKKKSMESTKIAIDVGFCHIDCSHLYQNEEEIGQAILSKIEDGTVKREDIFYTSKL 85
Cdd:cd19108   1 QRVKLNDGHFIPVLGFGTYAPEEVPKSKALEATKLAIDAGFRHIDSAYLYQNEEEVGQAIRSKIADGTVKREDIFYTSKL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  86 WSTSHRPELVRPSLENSLRKLNLDYVDLYLIHFPVSLKPGNELLPKDEHGNLIFDTVDLCDTWEAMEKCKDAGLAKSIGV 165
Cdd:cd19108  81 WCTFHRPELVRPALEKSLKKLQLDYVDLYLIHFPVALKPGEELFPKDENGKLIFDTVDLCATWEAMEKCKDAGLAKSIGV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 166 SNFNRRQLEMILNKPGLKYKPVCNQVECHLYLNQSKLLAYCKMNDIVLVAYGALGTQRYKYCINEDTPVLLDDPVLCAMA 245
Cdd:cd19108 161 SNFNRRQLEMILNKPGLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAYSALGSQRDKEWVDQNSPVLLEDPVLCALA 240

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19527284 246 KKYKRTPALIALRYQLDRGIVALAKSFNEERIRENMQVFDFQLASDDMKILDGLDRNLRYFPA 308
Cdd:cd19108 241 KKHKRTPALIALRYQLQRGVVVLAKSFNEKRIKENLQVFEFQLTSEDMKALDGLNRNLRYLPA 303

Name

Accession

Description

Interval

E-value

AKR_AKR1C1-35

cd19108

AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) ...

6-308

0e+00

Pssm-ID: 381334 [Multi-domain] Cd Length: 303 Bit Score: 676.26 E-value: 0e+00

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284   6 QKIELNDGHSIPVLGFGTYATEEHLKKKSMESTKIAIDVGFCHIDCSHLYQNEEEIGQAILSKIEDGTVKREDIFYTSKL 85
Cdd:cd19108   1 QRVKLNDGHFIPVLGFGTYAPEEVPKSKALEATKLAIDAGFRHIDSAYLYQNEEEVGQAIRSKIADGTVKREDIFYTSKL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  86 WSTSHRPELVRPSLENSLRKLNLDYVDLYLIHFPVSLKPGNELLPKDEHGNLIFDTVDLCDTWEAMEKCKDAGLAKSIGV 165
Cdd:cd19108  81 WCTFHRPELVRPALEKSLKKLQLDYVDLYLIHFPVALKPGEELFPKDENGKLIFDTVDLCATWEAMEKCKDAGLAKSIGV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 166 SNFNRRQLEMILNKPGLKYKPVCNQVECHLYLNQSKLLAYCKMNDIVLVAYGALGTQRYKYCINEDTPVLLDDPVLCAMA 245
Cdd:cd19108 161 SNFNRRQLEMILNKPGLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAYSALGSQRDKEWVDQNSPVLLEDPVLCALA 240

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19527284 246 KKYKRTPALIALRYQLDRGIVALAKSFNEERIRENMQVFDFQLASDDMKILDGLDRNLRYFPA 308
Cdd:cd19108 241 KKHKRTPALIALRYQLQRGVVVLAKSFNEKRIKENLQVFEFQLTSEDMKALDGLNRNLRYLPA 303

ARA1

COG0656

Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ...

12-307

5.74e-113

Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];

Pssm-ID: 440421 [Multi-domain] Cd Length: 259 Bit Score: 327.78 E-value: 5.74e-113

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  12 DGHSIPVLGFGTY-ATEEHLKkksmESTKIAIDVGFCHIDCSHLYQNEEEIGQAIlskiEDGTVKREDIFYTSKLWSTSH 90
Cdd:COG0656   1 NGVEIPALGLGTWqLPGEEAA----AAVRTALEAGYRHIDTAAMYGNEEGVGEAI----AASGVPREELFVTTKVWNDNH 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  91 RPELVRPSLENSLRKLNLDYVDLYLIHFPVSlkpgnellpkdehgnlifdtVDLCDTWEAMEKCKDAGLAKSIGVSNFNR 170
Cdd:COG0656  73 GYDDTLAAFEESLERLGLDYLDLYLIHWPGP--------------------GPYVETWRALEELYEEGLIRAIGVSNFDP 132

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 171 RQLEMILNKPGlkYKPVCNQVECHLYLNQSKLLAYCKMNDIVLVAYGALGTQRykycinedtpvLLDDPVLCAMAKKYKR 250
Cdd:COG0656 133 EHLEELLAETG--VKPAVNQVELHPYLQQRELLAFCREHGIVVEAYSPLGRGK-----------LLDDPVLAEIAEKHGK 199

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 19527284 251 TPALIALRYQLDRGIVALAKSFNEERIRENMQVFDFQLASDDMKILDGLDRNLRYFP 307
Cdd:COG0656 200 TPAQVVLRWHLQRGVVVIPKSVTPERIRENLDAFDFELSDEDMAAIDALDRGERLGP 256

dkgA

PRK11565

2,5-didehydrogluconate reductase DkgA;

8-307

2.14e-62

2,5-didehydrogluconate reductase DkgA;

Pssm-ID: 183203 [Multi-domain] Cd Length: 275 Bit Score: 199.53 E-value: 2.14e-62

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284    8 IELNDGHSIPVLGFGTYateehlkKKSMESTKIAI----DVGFCHIDCSHLYQNEEEIGQAIlskiEDGTVKREDIFYTS 83
Cdd:PRK11565   7 IKLQDGNVMPQLGLGVW-------QASNEEVITAIhkalEVGYRSIDTAAIYKNEEGVGKAL----KEASVAREELFITT 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284   84 KLWSTSHRPelVRPSLENSLRKLNLDYVDLYLIHFPVslkpgnellPKDEHgnlifdtvdLCDTWEAMEKCKDAGLAKSI 163
Cdd:PRK11565  76 KLWNDDHKR--PREALEESLKKLQLDYVDLYLMHWPV---------PAIDH---------YVEAWKGMIELQKEGLIKSI 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  164 GVSNFNRRQLEMILNKPGLKykPVCNQVECHLYLNQSKLLAYCKMNDIVL-----VAYGALGtqrykycinedtpvLLDD 238
Cdd:PRK11565 136 GVCNFQIHHLQRLIDETGVT--PVINQIELHPLMQQRQLHAWNATHKIQTeswspLAQGGKG--------------VFDQ 199

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19527284  239 PVLCAMAKKYKRTPALIALRYQLDRGIVALAKSFNEERIRENMQVFDFQLASDDMKILDGLDRNLRYFP 307
Cdd:PRK11565 200 KVIRDLADKYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVFDFRLDKDELGEIAKLDQGKRLGP 268

Aldo_ket_red

pfam00248

Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ...

19-300

1.73e-60

Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.

Pssm-ID: 425554 [Multi-domain] Cd Length: 290 Bit Score: 194.84 E-value: 1.73e-60

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284    19 LGFGTYATEEHLKKKSMEST----KIAIDVGFCHIDCSHLY---QNEEEIGQAIlskiEDGTVKREDIFYTSKL------ 85
Cdd:pfam00248   1 IGLGTWQLGGGWGPISKEEAlealRAALEAGINFIDTAEVYgdgKSEELLGEAL----KDYPVKRDKVVIATKVpdgdgp 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284    86 WSTSHRPELVRPSLENSLRKLNLDYVDLYLIHFPvslkpgnellpkdehgnliFDTVDLCDTWEAMEKCKDAGLAKSIGV 165
Cdd:pfam00248  77 WPSGGSKENIRKSLEESLKRLGTDYIDLYYLHWP-------------------DPDTPIEETWDALEELKKEGKIRAIGV 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284   166 SNFNRRQLEMILNKPglKYKPVCNQVECHLY--LNQSKLLAYCKMNDIVLVAYGALGTQRYKYCINEDTPV--------- 234
Cdd:pfam00248 138 SNFDAEQIEKALTKG--KIPIVAVQVEYNLLrrRQEEELLEYCKKNGIPLIAYSPLGGGLLTGKYTRDPDKgpgerrrll 215

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19527284   235 -------LLDDPVLCAMAKKYKRTPALIALRY--QLDRGIVALAKSFNEERIRENMQVFDFQLASDDMKILDGLD 300
Cdd:pfam00248 216 kkgtplnLEALEALEEIAKEHGVSPAQVALRWalSKPGVTIPIPGASNPEQLEDNLGALEFPLSDEEVARIDELL 290

Name

Accession

Description

Interval

E-value

AKR_AKR1C1-35

cd19108

AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) ...

6-308

0e+00

Pssm-ID: 381334 [Multi-domain] Cd Length: 303 Bit Score: 676.26 E-value: 0e+00

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284   6 QKIELNDGHSIPVLGFGTYATEEHLKKKSMESTKIAIDVGFCHIDCSHLYQNEEEIGQAILSKIEDGTVKREDIFYTSKL 85
Cdd:cd19108   1 QRVKLNDGHFIPVLGFGTYAPEEVPKSKALEATKLAIDAGFRHIDSAYLYQNEEEVGQAIRSKIADGTVKREDIFYTSKL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  86 WSTSHRPELVRPSLENSLRKLNLDYVDLYLIHFPVSLKPGNELLPKDEHGNLIFDTVDLCDTWEAMEKCKDAGLAKSIGV 165
Cdd:cd19108  81 WCTFHRPELVRPALEKSLKKLQLDYVDLYLIHFPVALKPGEELFPKDENGKLIFDTVDLCATWEAMEKCKDAGLAKSIGV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 166 SNFNRRQLEMILNKPGLKYKPVCNQVECHLYLNQSKLLAYCKMNDIVLVAYGALGTQRYKYCINEDTPVLLDDPVLCAMA 245
Cdd:cd19108 161 SNFNRRQLEMILNKPGLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAYSALGSQRDKEWVDQNSPVLLEDPVLCALA 240

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19527284 246 KKYKRTPALIALRYQLDRGIVALAKSFNEERIRENMQVFDFQLASDDMKILDGLDRNLRYFPA 308
Cdd:cd19108 241 KKHKRTPALIALRYQLQRGVVVLAKSFNEKRIKENLQVFEFQLTSEDMKALDGLNRNLRYLPA 303

AKR_AKR1D1-3

cd19109

AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes ...

13-319

3.71e-164

AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes 3-oxo-5-beta-steroid 4-dehydrogenase (EC 1.3.1.3) from Homo sapiens (AKR1D1), Rattus norvegicus (liver, AKR1D2), and Oryctolagus cuniculus (AKR1D3). 3-oxo-5-beta-steroid 4-dehydrogenase, also called delta(4)-3-ketosteroid 5-beta-reductase (EC 1.3.99.6), or delta(4)-3-oxosteroid 5-beta-reductase, or 5-beta-reductase, efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites.

Pssm-ID: 381335 [Multi-domain] Cd Length: 308 Bit Score: 459.26 E-value: 3.71e-164

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  13 GHSIPVLGFGTYA-TEEHLKKKSMESTKIAIDVGFCHIDCSHLYQNEEEIGQAILSKIEDGTVKREDIFYTSKLWSTSHR 91
Cdd:cd19109   1 GNSIPIIGLGTYSePKTTPKGACAEAVKVAIDTGYRHIDGAYIYQNEHEVGQAIREKIAEGKVKREDIFYCGKLWNTCHP 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  92 PELVRPSLENSLRKLNLDYVDLYLIHFPVSLKPGNELLPKDEHGNLIFDTVDLCDTWEAMEKCKDAGLAKSIGVSNFNRR 171
Cdd:cd19109  81 PELVRPTLERTLKVLQLDYVDLYIIEMPMAFKPGDEIYPRDENGKWLYHKTNLCATWEALEACKDAGLVKSIGVSNFNRR 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 172 QLEMILNKPGLKYKPVCNQVECHLYLNQSKLLAYCKMNDIVLVAYGALGTQRYKYCINEDTPVLLDDPVLCAMAKKYKRT 251
Cdd:cd19109 161 QLELILNKPGLKHKPVSNQVECHPYFTQPKLLEFCQQHDIVIVAYSPLGTCRDPIWVNVSSPPLLEDPLLNSIGKKYNKT 240

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19527284 252 PALIALRYQLDRGIVALAKSFNEERIRENMQVFDFQLASDDMKILDGLDRNLRYFPADMFKAHPNFPF 319
Cdd:cd19109 241 AAQVVLRFNIQRGVVVIPKSFNPERIKENFQIFDFSLTEEEMKDIEALNKNVRYVELLMWRDHPEYPF 308

AKR_AKR1B1-19

cd19107

AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase ...

13-323

6.02e-128

AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase (AR, EC 1.1.1.21) from Homo sapiens (AKR1B1), Oryctolagus cuniculus (kidney, AKR1B2), Mus musculus (AKR1B3), Rattus norvegicus (lens, AKR1B4), Bos taurus (lens/testis, AKR1B5), and Sus scrofa (lens, AKR1B6), aldose reductase-related protein 1 (ALD1, EC1.1.1.21) from Mus musculus (AKR1B7), Rattus norvegicus (AKR1B14), and Homo sapiens (AKR1B15), Mus musculus fibroblast growth factor induced protein (FR-1 or AKR1B8, EC 1.1.1.21), Cricetulus griseus aldose reductase-related protein 2 (ALD2 or AKR1B9, EC 1.1.1.21), aldose reductase-like from Homo sapiens (ARL-1 or AKR1B10) and Rattus norvegicus (AKR1B13), aldo-keto reductase from Gallus domesticus (eye, tongue, esophagus, AKR1B12), and Oryctolagus cuniculus AR-like protein (3beta-HSD, AKR1B19). AR, also called aldehyde reductase, catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. ALD1 reduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols. It may play a role in the metabolism of xenobiotic aromatic aldehydes. FR-1, also called aldose reductase-related protein 2, or fibroblast growth factor-regulated protein (FGFRP), is induced by fibroblast growth factor-1. It may play a role in the regulation of the cell cycle. FR-1 belongs to the NADPH-dependent aldo-keto reductase family. ALD2 is an inducible aldo-keto reductase with a preference for aliphatic substrates. It can also act on small aromatic aldehydes, steroid aldehydes and some ketone substrates. ARL-1, also called aldose reductase-like, or aldose reductase-related protein (ARP), or small intestine reductase, or SI reductase, acts as all-trans-retinaldehyde reductase that can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). It may be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. AKR1B15, also called estradiol 17-beta-dehydrogenase AKR1B15, is a mitochondrial aldo-keto reductase that catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs. It has a strong selectivity towards NADP(H). AKR1B19 is aldose reductase-like that may show 3-beta-hydroxysteroid dehydrogenase (3beta-HSD) activity.

Pssm-ID: 381333 [Multi-domain] Cd Length: 307 Bit Score: 367.51 E-value: 6.02e-128

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  13 GHSIPVLGFGTYATEehlKKKSMESTKIAIDVGFCHIDCSHLYQNEEEIGQAILSKIEDGTVKREDIFYTSKLWSTSHRP 92
Cdd:cd19107   1 GAKMPILGLGTWKSP---PGQVTEAVKVAIDAGYRHIDCAYVYQNENEVGEAIQEKIKEQVVKREDLFIVSKLWCTFHEK 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  93 ELVRPSLENSLRKLNLDYVDLYLIHFPVSLKPGNELLPKDEHGNLIFDTVDLCDTWEAMEKCKDAGLAKSIGVSNFNRRQ 172
Cdd:cd19107  78 GLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKELFPLDESGNVIPSDTTFLDTWEAMEELVDEGLVKAIGVSNFNHLQ 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 173 LEMILNKPGLKYKPVCNQVECHLYLNQSKLLAYCKMNDIVLVAYGALGTQRYKYCINEDtPVLLDDPVLCAMAKKYKRTP 252
Cdd:cd19107 158 IERILNKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPED-PSLLEDPKIKEIAAKHNKTT 236

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19527284 253 ALIALRYQLDRGIVALAKSFNEERIRENMQVFDFQLASDDMKILDGLDRNLRYFPADMFKAHPNFPFFDEY 323
Cdd:cd19107 237 AQVLIRFPIQRNLVVIPKSVTPERIAENFKVFDFELSSEDMATILSFNRNWRACALLSCSSHKDYPFHAEY 307

AKR_AKR1A1-4

cd19106

AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol ...

10-306

1.87e-127

AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol dehydrogenase [NADP(+)] (ALR, EC 1.1.1.2) from Homo sapiens (AKR1A1), Sus scrofa (AKR1A2), Rattus norvegicus (liver, AKR1A3), and Mus musculus (AKR1A4). ALR, also known as aldehyde reductase, or ALDR1, catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid.

Pssm-ID: 381332 [Multi-domain] Cd Length: 305 Bit Score: 366.32 E-value: 1.87e-127

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  10 LNDGHSIPVLGFGTYATEEHLKKksmESTKIAIDVGFCHIDCSHLYQNEEEIGQAILSKI-EDGTVKREDIFYTSKLWST 88
Cdd:cd19106   1 LHTGQKMPLIGLGTWKSKPGQVK---AAVKYALDAGYRHIDCAAVYGNEQEVGEALKEKVgPGKAVPREDLFVTSKLWNT 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  89 SHRPELVRPSLENSLRKLNLDYVDLYLIHFPVSLKPGNELLPKDEHGNLIFDTVDLCDTWEAMEKCKDAGLAKSIGVSNF 168
Cdd:cd19106  78 KHHPEDVEPALRKTLKDLQLDYLDLYLIHWPYAFERGDNPFPKNPDGTIRYDSTHYKETWKAMEKLVDKGLVKAIGLSNF 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 169 NRRQLEMILNKPglKYKPVCNQVECHLYLNQSKLLAYCKMNDIVLVAYGALGTQRYKYcINEDTPVLLDDPVLCAMAKKY 248
Cdd:cd19106 158 NSRQIDDILSVA--RIKPAVLQVECHPYLAQNELIAHCKARGLVVTAYSPLGSPDRPW-AKPDEPVLLEEPKVKALAKKY 234

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 19527284 249 KRTPALIALRYQLDRGIVALAKSFNEERIRENMQVFDFQLASDDMKILDGLDRNLRYF 306
Cdd:cd19106 235 NKSPAQILLRWQVQRGVVVIPKSVTPSRIKQNIQVFDFTLSPEEMKQLDALNRNWRYI 292

AKR_AKR2E1-5

cd19116

AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a ...

7-306

6.54e-126

AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a founding member of aldo-keto reductase family 2 member E4 (AKR2E4). It is a NADP-dependent oxidoreductase with high 3-dehydroecdysone reductase activity. It may play a role in the regulation of molting and has lower activity with phenylglyoxal and isatin (in vitro). This family also includes 3-dehydroecdysone 3b-reductase from Spodoptera littoralis and Trichoplusia ni, DL-glyceraldehyde reductase from Drosophila melanogaster, aldo-keto reductase from Bombyx mori, which correspond to aldo-keto reductase family 2 member E1, E2, E3 and E5 (AKR2E1/2/3/5), respectively.

Pssm-ID: 381342 [Multi-domain] Cd Length: 292 Bit Score: 361.98 E-value: 6.54e-126

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284   7 KIELNDGHSIPVLGFGTYATeeHLKKKSMESTKIAIDVGFCHIDCSHLYQNEEEIGQAILSKIEDGTVKREDIFYTSKLW 86
Cdd:cd19116   2 TIKLNDGNEIPAIALGTWKL--KDDEGVRQAVKHAIEAGYRHIDTAYLYGNEAEVGEAIREKIAEGVVKREDLFITTKLW 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  87 STSHRPELVRPSLENSLRKLNLDYVDLYLIHFPVSLKPGNEllpKDEHGNLIFDTVDLCDTWEAMEKCKDAGLAKSIGVS 166
Cdd:cd19116  80 NSYHEREQVEPALRESLKRLGLDYVDLYLIHWPVAFKENND---SESNGDGSLSDIDYLETWRGMEDLVKLGLTRSIGVS 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 167 NFNRRQLEMILNkpGLKYKPVCNQVECHLYLNQSKLLAYCKMNDIVLVAYGALGtqRYKYCINEDTPVLLDDPVLCAMAK 246
Cdd:cd19116 157 NFNSEQINRLLS--NCNIKPAVNQIEVHPTLTQEKLVAYCQSNGIVVMAYSPFG--RLVPRGQTNPPPRLDDPTLVAIAK 232

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 247 KYKRTPALIALRYQLDRGIVALAKSFNEERIRENMQVFDFQLASDDMKILDGLDRNLRYF 306
Cdd:cd19116 233 KYGKTTAQIVLRYLIDRGVVPIPKSSNKKRIKENIDIFDFQLTPEEVAALNSFNTNQRVY 292

AKR_AKR1-5-like

cd19071

AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ...

16-297

1.38e-116

AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.

Pssm-ID: 381297 [Multi-domain] Cd Length: 251 Bit Score: 336.38 E-value: 1.38e-116

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  16 IPVLGFGTYateeHLKKKSM-ESTKIAIDVGFCHIDCSHLYQNEEEIGQAILSKIedgtVKREDIFYTSKLWSTSHRPEL 94
Cdd:cd19071   1 MPLIGLGTY----KLKPEETaEAVLAALEAGYRHIDTAAAYGNEAEVGEAIRESG----VPREELFITTKLWPTDHGYER 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  95 VRPSLENSLRKLNLDYVDLYLIHFPVSLKPGNellpkdehgnlifDTVDLCDTWEAMEKCKDAGLAKSIGVSNFNRRQLE 174
Cdd:cd19071  73 VREALEESLKDLGLDYLDLYLIHWPVPGKEGG-------------SKEARLETWRALEELVDEGLVRSIGVSNFNVEHLE 139

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 175 MILNKPglKYKPVCNQVECHLYLNQSKLLAYCKMNDIVLVAYGALGTQRYKycinedtpvLLDDPVLCAMAKKYKRTPAL 254
Cdd:cd19071 140 ELLAAA--RIKPAVNQIELHPYLQQKELVEFCKEHGIVVQAYSPLGRGRRP---------LLDDPVLKEIAKKYGKTPAQ 208

                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 19527284 255 IALRYQLDRGIVALAKSFNEERIRENMQVFDFQLASDDMKILD 297
Cdd:cd19071 209 VLLRWALQRGVVVIPKSSNPERIKENLDVFDFELSEEDMAAID 251

AKR_AKR1G1_CeAKR

cd19154

Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding ...

8-306

1.14e-113

Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.

Pssm-ID: 381380 [Multi-domain] Cd Length: 303 Bit Score: 331.30 E-value: 1.14e-113

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284   8 IELNDGHSIPVLGFGTY-ATEEHLKkksmESTKIAIDVGFCHIDCSHLYQNEEEIGQAILSKIEDGTVKREDIFYTSKLW 86
Cdd:cd19154   4 ITLSNGVKMPLIGLGTWqSKGAEGI----TAVRTALKAGYRLIDTAFLYQNEEAIGEALAELLEEGVVKREDLFITTKLW 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  87 STSHRPELVRPSLENSLRKLNLDYVDLYLIHFPVSLKPGNELLPKDEHGNLIFDTVDLCDTWEAMEKCKDAGLAKSIGVS 166
Cdd:cd19154  80 THEHAPEDVEEALRESLKKLQLEYVDLYLIHAPAAFKDDEGESGTMENGMSIHDAVDVEDVWRGMEKVYDEGLTKAIGVS 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 167 NFNRRQLEMILNKPglKYKPVCNQVECHLYLNQSKLLAYCKMNDIVLVAYGALG----TQRYKYCINEDTPVLLDDPVLC 242
Cdd:cd19154 160 NFNNDQIQRILDNA--RVKPHNNQVECHLYFPQKELVEFCKKHNISVTSYATLGspgrANFTKSTGVSPAPNLLQDPIVK 237

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19527284 243 AMAKKYKRTPALIALRYQLDRGIVALAKSFNEERIRENMQVFDFQLASDDMKILDGLDRNLRYF 306
Cdd:cd19154 238 AIAEKHGKTPAQVLLRYLLQRGIAVIPKSATPSRIKENFNIFDFSLSEEDMATLEEIEKSLRLF 301

ARA1

COG0656

Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ...

12-307

5.74e-113

Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];

Pssm-ID: 440421 [Multi-domain] Cd Length: 259 Bit Score: 327.78 E-value: 5.74e-113

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  12 DGHSIPVLGFGTY-ATEEHLKkksmESTKIAIDVGFCHIDCSHLYQNEEEIGQAIlskiEDGTVKREDIFYTSKLWSTSH 90
Cdd:COG0656   1 NGVEIPALGLGTWqLPGEEAA----AAVRTALEAGYRHIDTAAMYGNEEGVGEAI----AASGVPREELFVTTKVWNDNH 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  91 RPELVRPSLENSLRKLNLDYVDLYLIHFPVSlkpgnellpkdehgnlifdtVDLCDTWEAMEKCKDAGLAKSIGVSNFNR 170
Cdd:COG0656  73 GYDDTLAAFEESLERLGLDYLDLYLIHWPGP--------------------GPYVETWRALEELYEEGLIRAIGVSNFDP 132

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 171 RQLEMILNKPGlkYKPVCNQVECHLYLNQSKLLAYCKMNDIVLVAYGALGTQRykycinedtpvLLDDPVLCAMAKKYKR 250
Cdd:COG0656 133 EHLEELLAETG--VKPAVNQVELHPYLQQRELLAFCREHGIVVEAYSPLGRGK-----------LLDDPVLAEIAEKHGK 199

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 19527284 251 TPALIALRYQLDRGIVALAKSFNEERIRENMQVFDFQLASDDMKILDGLDRNLRYFP 307
Cdd:COG0656 200 TPAQVVLRWHLQRGVVVIPKSVTPERIRENLDAFDFELSDEDMAAIDALDRGERLGP 256

AKR_AKR1E1-2

cd19110

AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1, ...

16-323

1.90e-112

AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1,5-anhydro-D-fructose reductase (EC 1.1.1.263) from Mus musculus (liver, AKR1E1) and Homo sapiens (AKR1E2). 1,5-anhydro-D-fructose reductase), also called AF reductase, or aldo-keto reductase family 1 member C-like protein 2 (AKR1CL2), catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol. AKR1E2 is a testis aldo-keto reductase (tAKR), which is also known as testis-specific protein (TSP), or LoopADR.

Pssm-ID: 381336 [Multi-domain] Cd Length: 301 Bit Score: 328.07 E-value: 1.90e-112

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  16 IPVLGFGTYATEehlKKKSMESTKIAIDVGFCHIDCSHLYQNEEEIGQAILSKIEDGTVKREDIFYTSKLWSTSHRPELV 95
Cdd:cd19110   4 IPAVGLGTWKAS---PGEVTEAVKVAIDAGYRHFDCAYLYHNESEVGAGIREKIKEGVVRREDLFIVSKLWCTCHKKSLV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  96 RPSLENSLRKLNLDYVDLYLIHFPVSLKPGNELLPKDEHGNLIFDTVDLCDTWEAMEKCKDAGLAKSIGVSNFNRRQLEM 175
Cdd:cd19110  81 KTACTRSLKALKLNYLDLYLIHWPMGFKPGEPDLPLDRSGMVIPSDTDFLDTWEAMEDLVIEGLVKNIGVSNFNHEQLER 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 176 ILNKPGLKYKPVCNQVECHLYLNQSKLLAYCKMNDIVLVAYGALGTQrykyciNEDTPvLLDDPVLCAMAKKYKRTPALI 255
Cdd:cd19110 161 LLNKPGLRVKPVTNQIECHPYLTQKKLISFCQSRNVSVTAYRPLGGS------CEGVD-LIDDPVIQRIAKKHGKSPAQI 233

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19527284 256 ALRYQLDRGIVALAKSFNEERIRENMQVFDFQLASDDMKILDGLDRNLRYFPADMFKAHPNFPFFDEY 323
Cdd:cd19110 234 LIRFQIQRNVIVIPKSVTPSRIKENIQVFDFELTEHDMDNLLSLDRNLRLATFPITENHKDYPFHIEY 301

AKR_AKR3G1

cd19123

AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a ...

10-306

7.26e-111

AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a founding member of aldo-keto reductase family 3 member G1 (AKR3G1). It is an aldo/keto reductase that catalyzes the NADPH-dependent reduction of aldehyde- and ketone-groups of different classes of carbonyl compounds to the corresponding alcohols.

Pssm-ID: 381349 [Multi-domain] Cd Length: 297 Bit Score: 323.98 E-value: 7.26e-111

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  10 LNDGHSIPVLGFGTYATEehlKKKSMESTKIAIDVGFCHIDCSHLYQNEEEIGQAILSKIEDGTVKREDIFYTSKLWSTS 89
Cdd:cd19123   6 LSNGDLIPALGLGTWKSK---PGEVGQAVKQALEAGYRHIDCAAIYGNEAEIGAALAEVFKEGKVKREDLWITSKLWNNS 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  90 HRPELVRPSLENSLRKLNLDYVDLYLIHFPVSLKPGnELLPKDEHGNLIFDTVDLCDTWEAMEKCKDAGLAKSIGVSNFN 169
Cdd:cd19123  83 HAPEDVLPALEKTLADLQLDYLDLYLMHWPVALKKG-VGFPESGEDLLSLSPIPLEDTWRAMEELVDKGLCRHIGVSNFS 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 170 RRQLEMILNKPglKYKPVCNQVECHLYLNQSKLLAYCKMNDIVLVAYGALGT-QRYKYCINEDTPVLLDDPVLCAMAKKY 248
Cdd:cd19123 162 VKKLEDLLATA--RIKPAVNQVELHPYLQQPELLAFCRDNGIHLTAYSPLGSgDRPAAMKAEGEPVLLEDPVINKIAEKH 239

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 19527284 249 KRTPALIALRYQLDRGIVALAKSFNEERIRENMQVFDFQLASDDMKILDGLDRNLRYF 306
Cdd:cd19123 240 GASPAQVLIAWAIQRGTVVIPKSVNPERIQQNLEAAEVELDASDMATIAALDRHHRYV 297

AKR_AKR4C1-15

cd19125

AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase ...

9-304

3.89e-101

AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase (ALR) from Hordeum vulgare (AKR4C1), Bromus inermis (AKR4C2), Avena fatua (AKR4C3), and Xerophyta viscosa (AKR4C4), two aldose reductases, DpAR1 (AKR4C5) and DpAR2(AKR4C6), from Digitalis purpurea, aldehyde reductase from Zea mays (AKR4C7), four aldo-keto reductases from Arabidopsis thaliana (AKR4C8-11), and another three aldo-keto reductases from Aloe arborescens (AKR4C12) and Oryza sativa (AKR4C14/15). ALR (EC 1.1.1.21), also called AR, aldehyde reductase, or polyol dehydrogenase (NADP(+)), is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. Both DpAR1 and DpAR2 reduce the ketone group of steroid structures. They may be involved in plant steroid metabolism in general and in cardenolide biosynthesis in particular. Plant aldo-keto reductases of the AKR4C subfamily play key roles during stress and are attractive targets for developing stress-tolerant crops.

Pssm-ID: 381351 [Multi-domain] Cd Length: 287 Bit Score: 298.88 E-value: 3.89e-101

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284   9 ELNDGHSIPVLGFGTYATEEHLKKKSMestKIAIDVGFCHIDCSHLYQNEEEIGQAILSKIEDGTVKREDIFYTSKLWST 88
Cdd:cd19125   4 KLNTGAKIPAVGLGTWQADPGVVGNAV---KTAIKEGYRHIDCAAIYGNEKEIGKALKKLFEDGVVKREDLFITSKLWCT 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  89 SHRPELVRPSLENSLRKLNLDYVDLYLIHFPVSLKPGNellPKDEHGNLIfdTVDLCDTWEAMEKCKDAGLAKSIGVSNF 168
Cdd:cd19125  81 DHAPEDVPPALEKTLKDLQLDYLDLYLIHWPVRLKKGA---HMPEPEEVL--PPDIPSTWKAMEKLVDSGKVRAIGVSNF 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 169 NRRQLEMILNKPglKYKPVCNQVECHLYLNQSKLLAYCKMNDIVLVAYGALGTQRYKYCinedTPVLLDDPVLCAMAKKY 248
Cdd:cd19125 156 SVKKLEDLLAVA--RVPPAVNQVECHPGWQQDKLHEFCKSKGIHLSAYSPLGSPGTTWV----KKNVLKDPIVTKVAEKL 229

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 19527284 249 KRTPALIALRYQLDRGIVALAKSFNEERIRENMQVFDFQLASDDMKILDGLDRNLR 304
Cdd:cd19125 230 GKTPAQVALRWGLQRGTSVLPKSTNEERIKENIDVFDWSIPEEDFAKFSSIEQQRR 285

AKR_AKR4A_4B

cd19124

AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes ...

12-299

7.30e-93

AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes Glycine max NAD(P)H-dependent 6'-deoxychalcone synthase (6DCS, EC 3.1.170), chalcone reductase (CHR, EC 2.3.1.74) from Medicago sativa, Glycyrrhiza echinate, and Glycyrrhiza glabra, which are founding members of aldo-keto reductase family 4 member A1 (AKR4A1), A2 (AKR4A2), A3 (AKR4A3), and A4 (AKR4A4), respectively. NAD(P)H-6DCS co-acts with chalcone synthase in formation of 4,2',4'-trihydroxychalcone, involved in the biosynthesis of glyceollin type phytoalexins. CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. The AKR4B family of AKR includes Sesbania rostrate chalcone reductase (CHR, AKR4B1), Papaver somniferum codeinone reductase (COR, AKR4B2/ AKR4B3), Fragaria x ananassa D-galacturonate reductase (GalUR, AKR4B4), deoxymugineic acid synthase 1 (DMAS1) from Zea mays (AKR4B5), Oryza sativa (AKR4B6), Hordeum vulgare (AKR4B7), Triticum aestivum (AKR4B8), and Erythroxylum coca methylecgonone reductase (MecgoR, AKR4B10). CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. NADPH-dependent COR and non-functional NADPH-dependent COR from Papaver somniferum are founding members of aldo-keto reductase family 4 member B2 (AKR4B2) and B3 (AKR4B3), respectively. NADPH-dependent COR (EC 1.1.1.247) reduces codeinone to codeine in the penultimate step in morphine biosynthesis. It can use morphinone, hydrocodone, and hydromorphone as substrates during reductive reaction with NADPH as cofactor, and morphine and dihydrocodeine as substrates during oxidative reaction with NADP as cofactor. GalUR (EC 1.1.1.365), also called aldo-keto reductase 2 (AKR2), is involved in ascorbic acid (vitamin C) biosynthesis by catalyzing the conversion from L-galactonate and NADP(+) to D-galacturonate and NADPH. DMAS1 (EC 1.1.1.285) catalyzes the reduction of a 3''-keto intermediate during the biosynthesis of 2'-deoxymugineic acid (DMA) from L-Met. It is involved in the formation of phytosiderophores (MAs) belonging to the mugineic acid family and required to acquire iron. MecgoR catalyzes the stereospecific reduction of methylecgonone to methylecgonine, the penultimate step in cocaine biosynthesis.

Pssm-ID: 381350 [Multi-domain] Cd Length: 281 Bit Score: 277.61 E-value: 7.30e-93

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  12 DGHSIPVLGFGTYAteehlKKKSMESTKI----AIDVGFCHIDCSHLYQNEEEIGQAILSKIEDGTVK-REDIFYTSKLW 86
Cdd:cd19124   1 SGQTMPVIGMGTAS-----DPPSPEDIKAavleAIEVGYRHFDTAAAYGTEEALGEALAEALRLGLVKsRDELFVTSKLW 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  87 STSHRPELVRPSLENSLRKLNLDYVDLYLIHFPVSLKPGNELLPKDEHgnlIFDTVDLCDTWEAMEKCKDAGLAKSIGVS 166
Cdd:cd19124  76 CSDAHPDLVLPALKKSLRNLQLEYVDLYLIHWPVSLKPGKFSFPIEEE---DFLPFDIKGVWEAMEECQRLGLTKAIGVS 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 167 NFNRRQLEMILNKPglKYKPVCNQVECHLYLNQSKLLAYCKMNDIVLVAYGALGTQRYKYcineDTPVLLDDPVLCAMAK 246
Cdd:cd19124 153 NFSCKKLQELLSFA--TIPPAVNQVEMNPAWQQKKLREFCKANGIHVTAYSPLGAPGTKW----GSNAVMESDVLKEIAA 226

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 19527284 247 KYKRTPALIALRYQLDRGIVALAKSFNEERIRENMQVFDFQLASDDMKILDGL 299
Cdd:cd19124 227 AKGKTVAQVSLRWVYEQGVSLVVKSFNKERMKQNLDIFDWELTEEDLEKISEI 279

AKR_AKR1I_CgAKR1

cd19155

Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi ...

8-306

6.05e-92

Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.

Pssm-ID: 381381 [Multi-domain] Cd Length: 307 Bit Score: 275.94 E-value: 6.05e-92

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284   8 IELNDGHSIPVLGFGTYATEEHLKKKSMEStkiAIDVGFCHIDCSHLYQNEEEIGQAILSKIEDGTVKREDIFYTSKLWS 87
Cdd:cd19155   4 VTFNNGEKMPVVGLGTWQSSPEEIETAVDT---ALEAGYRHIDTAYVYRNEAAIGNVLKKWIDSGKVKREELFIVTKLPP 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  88 TSHRPELVRPSLENSLRKLNLDYVDLYLIHFPVSLKpGNEL--LPKDEHGNLIFD-TVDLCDTWEAMEKCKDAGLAKSIG 164
Cdd:cd19155  81 GGNRREKVEKFLLKSLEKLQLDYVDLYLIHFPVGSL-SKEDdsGKLDPTGEHKQDyTTDLLDIWKAMEAQVDQGLTRSIG 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 165 VSNFNRRQLEMILNKPglKYKPVCNQVECHLYLNQSKLLAYCKMNDIVLVAYGALGTQ-RYKYC-----INEDTPVLLDD 238
Cdd:cd19155 160 LSNFNREQMARILKNA--RIKPANLQVELHVYLQQKDLVDFCSTHSITVTAYAPLGSPgAAHFSpgtgsPSGSSPDLLQD 237

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19527284 239 PVLCAMAKKYKRTPALIALRYQLDRGIVALAKSFNEERIRENMQVFDFQLASDDMKILDGLDRNLRYF 306
Cdd:cd19155 238 PVVKAIAERHGKSPAQVLLRWLMQRGVVVIPKSTNAARIKENFQVFDFELTEADMAKLSSLDKNIRGR 305

AKR_AKR1G1_1I

cd19111

Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase ...

13-306

1.13e-91

Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.

Pssm-ID: 381337 [Multi-domain] Cd Length: 286 Bit Score: 274.76 E-value: 1.13e-91

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  13 GHSIPVLGFGTY--ATEEhlkkkSMESTKIAIDVGFCHIDCSHLYQNEEEIGQAILSKIEDGTVKREDIFYTSKLWSTSH 90
Cdd:cd19111   1 GFPMPVIGLGTYqsPPEE-----VRAAVDYALFVGYRHIDTALSYQNEKAIGEALKWWLKNGKLKREEVFITTKLPPVYL 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  91 RPELVRPSLENSLRKLNLDYVDLYLIHFPVslkpGNELlpKDEHGNLIFDTVDLCDTWEAMEKCKDAGLAKSIGVSNFNR 170
Cdd:cd19111  76 EFKDTEKSLEKSLENLKLPYVDLYLIHHPC----GFVN--KKDKGERELASSDVTSVWRAMEALVSEGKVKSIGLSNFNP 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 171 RQLEMILNKPglKYKPVCNQVECHLYLNQSKLLAYCKMNDIVLVAYGALGT-QRYKYCINEDTPVLLDDPVLCAMAKKYK 249
Cdd:cd19111 150 RQINKILAYA--KVKPSNLQLECHAYLQQRELRKFCNKKNIVVTAYAPLGSpGRANQSLWPDQPDLLEDPTVLAIAKELD 227

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 19527284 250 RTPALIALRYQLDRGIVALAKSFNEERIRENMQVFDFQLASDDMKILDGLDRNLRYF 306
Cdd:cd19111 228 KTPAQVLLRFVLQRGTGVLPKSTNKERIEENFEVFDFELTEEHFKKLKTLDRNMKYF 284

AKR_BaDH-like

cd19129

Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium ...

11-305

3.14e-88

Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium diazoefficiens DH is the prototype of this family. It belongs to aldo/keto reductase family.

Pssm-ID: 381355 [Multi-domain] Cd Length: 295 Bit Score: 266.25 E-value: 3.14e-88

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  11 NDGHSIPVLGFGTYATEEHLKKksmESTKIAIDVGFCHIDCSHLYQNEEEIGQAILSKIEDGTVKREDIFYTSKLWSTSH 90
Cdd:cd19129   1 NGSGAIPALGFGTLIPDPSATR---NAVKAALEAGFRHFDCAERYRNEAEVGEAMQEVFKAGKIRREDLFVTTKLWNTNH 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  91 RPELVRPSLENSLRKLNLDYVDLYLIHFPVSLKPGNELLPKDEHGNLIFDT-VDLCDTWEAMEKCKDAGLAKSIGVSNFN 169
Cdd:cd19129  78 RPERVKPAFEASLKRLQLDYLDLYLIHTPFAFQPGDEQDPRDANGNVIYDDgVTLLDTWRAMERLVDEGRCKAIGLSDVS 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 170 RRQLEMILNKPglKYKPVCNQVECHLYLNQSKLLAYCKMNDIVLVAYGALGtqrykyciNEDTPVLLDDPVLCAMAKKYK 249
Cdd:cd19129 158 LEKLREIFEAA--RIKPAVVQVESHPYLPEWELLDFCKNHGIVLQAFAPLG--------HGMEPKLLEDPVITAIARRVN 227

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 19527284 250 RTPALIALRYQLDRGIVALAKSFNEERIRENmqvFDFQ-LASDDMK-ILDGLDRNLRY 305
Cdd:cd19129 228 KTPAQVLLAWAIQRGTALLTTSKTPSRIREN---FDIStLPEDAMReINEGIKTRYRF 282

AKR_AKR3B1-3

cd19118

AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde ...

10-299

1.43e-86

AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde reductase 1 (ARI, EC 1.1.1.2), Trichosporonoides megachilieni NADPH-dependent erthyrose reductase (ER) 1/2 and 3, are founding members of aldo-keto reductase family 3 member B1 (AKR3B1), B2 (AKR3B2), and B3 (AKR3B3), respectively. Sporidiobolus salmonicolor NADPH-ARI, also called alcohol dehydrogenase [NADP(+)], or aldehyde reductase I, or ALR 1, catalyzes the asymmetric reduction of aliphatic and aromatic aldehydes and ketones to an R-enantiomer. It reduces ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate. Trichosporonoides megachilieni NADPH-ERs catalyze the reduction of D-erythrose.

Pssm-ID: 381344 [Multi-domain] Cd Length: 283 Bit Score: 261.58 E-value: 1.43e-86

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  10 LNDGHSIPVLGFGTYATEEHLKKKSMestKIAIDVGFCHIDCSHLYQNEEEIGQAIL-SKIEDGTVKREDIFYTSKLWST 88
Cdd:cd19118   1 LNTGNKIPAIGLGTWQAEPGEVGAAV---KIALKAGYRHLDLAKVYQNQHEVGQALKeLLKEEPGVKREDLFITSKLWNN 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  89 SHRPELVRPSLENSLRKLNLDYVDLYLIHFPVSLKPGNELLPK----DEHGNLIFDT-VDLCDTWEAMEKCKDAGLAKSI 163
Cdd:cd19118  78 SHRPEYVEPALDDTLKELGLDYLDLYLIHWPVAFKPTGDLNPLtavpTNGGEVDLDLsVSLVDTWKAMVELKKTGKVKSI 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 164 GVSNFNRRQLEMILNKPGLkyKPVCNQVECHLYLNQSKLLAYCKMNDIVLVAYGALGTQRykycinEDTPVLLDDPVLCA 243
Cdd:cd19118 158 GVSNFSIDHLQAIIEETGV--VPAVNQIEAHPLLLQDELVDYCKSKNIHITAYSPLGNNL------AGLPLLVQHPEVKA 229

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 19527284 244 MAKKYKRTPALIALRYQLDRGIVALAKSFNEERIRENMQVFDfqLASDDMKILDGL 299
Cdd:cd19118 230 IAAKLGKTPAQVLIAWGIQRGHSVIPKSVTPSRIRSNFEQVE--LSDDEFNAVTAL 283

AKR_AKR2A1-2

cd19112

AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 ...

8-305

5.27e-85

AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 (NADP-dependent D-sorbitol-6-phosphate dehydrogenase or NADP-S6PDH) from Malus domestica, and AKR2A2 (NADPH-dependent mannose-6-phosphate reductase or NADPH-M6PR) from Apium graveolens. NADP-S6PDH (EC 1.1.1.200), also called aldose-6-phosphate reductase [NADPH], synthesizes sorbitol-6-phosphate, a key intermediate in the synthesis of sorbitol which is a major photosynthetic product in many members of the Rosaceae family. NADPH-M6PR (EC 1.1.1.224), also called NADPH-dependent M6P reductase, is a key enzyme involved in mannitol biosynthesis.

Pssm-ID: 381338 [Multi-domain] Cd Length: 308 Bit Score: 258.57 E-value: 5.27e-85

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284   8 IELNDGHSIPVLGFGTYATEEHLKKKSMEStkiAIDVGFCHIDCSHLYQNEEEIGQAILSKIEDGTVKREDIFYTSKLWS 87
Cdd:cd19112   3 ITLNSGHKMPVIGLGVWRMEPGEIKELILN---AIKIGYRHFDCAADYKNEKEVGEALAEAFKTGLVKREDLFITTKLWN 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  88 TSHrpELVRPSLENSLRKLNLDYVDLYLIHFPVSLK------PGNELlpkDEHGNL-IFDTVDLCDTWEAMEKCKDAGLA 160
Cdd:cd19112  80 SDH--GHVIEACKDSLKKLQLDYLDLYLVHFPVATKhtgvgtTGSAL---GEDGVLdIDVTISLETTWHAMEKLVSAGLV 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 161 KSIGVSNFnrrqlEMILNKPGLKY---KPVCNQVECHLYLNQSKLLAYCKMNDIVLVAYGALG-----TQRYKYCinedT 232
Cdd:cd19112 155 RSIGISNY-----DIFLTRDCLAYskiKPAVNQIETHPYFQRDSLVKFCQKHGISVTAHTPLGgaaanAEWFGSV----S 225

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19527284 233 PvlLDDPVLCAMAKKYKRTPALIALRYQLDRGIVALAKSFNEERIRENMQVFDFQLASDDMKILDGLDRNLRY 305
Cdd:cd19112 226 P--LDDPVLKDLAKKYGKSAAQIVLRWGIQRNTAVIPKSSKPERLKENIDVFDFQLSKEDMKLIKSLDRKYRT 296

AKR_AKR3F2_3

cd19073

Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti ...

16-297

2.39e-83

Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti isatin reductase and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.

Pssm-ID: 381299 [Multi-domain] Cd Length: 243 Bit Score: 251.81 E-value: 2.39e-83

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  16 IPVLGFGTYATEEhlkKKSMESTKIAIDVGFCHIDCSHLYQNEEEIGQAILskieDGTVKREDIFYTSKLWSTSHRPELV 95
Cdd:cd19073   1 IPALGLGTWQLRG---DDCANAVKEALELGYRHIDTAEIYNNEAEVGEAIA----ESGVPREDLFITTKVWRDHLRPEDL 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  96 RPSLENSLRKLNLDYVDLYLIHFPVSlkpgnellpkdehgnlifdTVDLCDTWEAMEKCKDAGLAKSIGVSNFNRRQLEM 175
Cdd:cd19073  74 KKSVDRSLEKLGTDYVDLLLIHWPNP-------------------TVPLEETLGALKELKEAGKVKSIGVSNFTIELLEE 134

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 176 ILNKPGLkyKPVCNQVECHLYLNQSKLLAYCKMNDIVLVAYGALGTQRykycinedtpvLLDDPVLCAMAKKYKRTPALI 255
Cdd:cd19073 135 ALDISPL--PIAVNQVEFHPFLYQAELLEYCRENDIVITAYSPLARGE-----------VLRDPVIQEIAEKYDKTPAQV 201

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 19527284 256 ALRYQLDRGIVALAKSFNEERIRENMQVFDFQLASDDMKILD 297
Cdd:cd19073 202 ALRWLVQKGIVVIPKASSEDHLKENLAIFDWELTSEDVAKID 243

AKR_AKR5C2

cd19131

Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; ...

8-300

1.05e-81

Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; Escherichia coli DkgA/YqhE is a founding member of aldo-keto reductase family 5 member C2 (AKR5C2). DkgA/YqhE (EC 1.1.1.274), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives.

Pssm-ID: 381357 [Multi-domain] Cd Length: 256 Bit Score: 248.06 E-value: 1.05e-81

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284   8 IELNDGHSIPVLGFGTYATEEhlkKKSMESTKIAIDVGFCHIDCSHLYQNEEEIGQAIlskiEDGTVKREDIFYTSKLWS 87
Cdd:cd19131   2 ITLNDGNTIPQLGLGVWQVSN---DEAASAVREALEVGYRSIDTAAIYGNEEGVGKAI----RASGVPREELFITTKLWN 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  88 TSHRPELVRPSLENSLRKLNLDYVDLYLIHFPVslkpgnellPKDEHgnlifdtvdLCDTWEAMEKCKDAGLAKSIGVSN 167
Cdd:cd19131  75 SDQGYDSTLRAFDESLRKLGLDYVDLYLIHWPV---------PAQDK---------YVETWKALIELKKEGRVKSIGVSN 136

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 168 FNRRQLEMILNKPGLKykPVCNQVECHLYLNQSKLLAYCKMNDIVLVAYGALGTQRykycinedtpvLLDDPVLCAMAKK 247
Cdd:cd19131 137 FTIEHLQRLIDETGVV--PVVNQIELHPRFQQRELRAFHAKHGIQTESWSPLGQGG-----------LLSDPVIGEIAEK 203

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 19527284 248 YKRTPALIALRYQLDRGIVALAKSFNEERIRENMQVFDFQLASDDMKILDGLD 300
Cdd:cd19131 204 HGKTPAQVVIRWHLQNGLVVIPKSVTPSRIAENFDVFDFELDADDMQAIAGLD 256

AKR_DrGR-like

cd19136

Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like ...

16-299

7.46e-81

Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like protein is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase similar to Bacillus subtilis glyoxal reductase (YvgN) that reduces glyoxal and methylglyoxal (2-oxopropanal).

Pssm-ID: 381362 [Multi-domain] Cd Length: 262 Bit Score: 246.00 E-value: 7.46e-81

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  16 IPVLGFGTYateeHLKKKSMESTKI--AIDVGFCHIDCSHLYQNEEEIGQAILSKIEDGTVKREDIFYTSKLWSTSHRPE 93
Cdd:cd19136   1 MPILGLGTF----RLRGEEEVRQAVdaALKAGYRLIDTASVYRNEADIGKALRDLLPKYGLSREDIFITSKLAPKDQGYE 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  94 LVRPSLENSLRKLNLDYVDLYLIHFpvslkPGNELLPKDEHGNLIFDTvdlcDTWEAMEKCKDAGLAKSIGVSNFNRRQL 173
Cdd:cd19136  77 KARAACLGSLERLGTDYLDLYLIHW-----PGVQGLKPSDPRNAELRR----ESWRALEDLYKEGKLRAIGVSNYTVRHL 147

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 174 EMILNKPglKYKPVCNQVECHLYLNQSKLLAYCKMNDIVLVAYGALGTQrykycinedTPVLLDDPVLCAMAKKYKRTPA 253
Cdd:cd19136 148 EELLKYC--EVPPAVNQVEFHPHLVQKELLKFCKDHGIHLQAYSSLGSG---------DLRLLEDPTVLAIAKKYGRTPA 216

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 19527284 254 LIALRYQLDRGIVALAKSFNEERIRENMQVFDFQLASDDMKILDGL 299
Cdd:cd19136 217 QVLLRWALQQGIGVIPKSTNPERIAENIKVFDFELSEEDMAELNAL 262

AKR_AKR3C2-3

cd19120

Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis ...

13-297

9.86e-81

Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis NADPH-dependent conjugated polyketone reductase C2 (CPR), and similar proteins; Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase (EC 1.1.1.190/EC 1.1.1.191) and Candida parapsilosis NADPH-dependent CPR (EC 1.1.1.358/EC 1.1.1.168) are founding members of aldo-keto reductase family 3 member C2 (AKR3C2) and C3 (AKR3C3), respectively. Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase catalyzes the conversion from (Indol-3-yl)ethanol to (indol-3-yl)acetaldehyde in a NAD/NADP-dependent manner. CPR, also called 2-dehydropantolactone reductase, or 2-dehydropantolactone reductase (A-specific), or ketopantoyl-lactone reductase, acts as a NADPH-dependent conjugated polyketone reductase with broad substrate specificity and strict stereospecificity. It reduces ketopantoyl lactone and isatin.

Pssm-ID: 381346 [Multi-domain] Cd Length: 269 Bit Score: 245.99 E-value: 9.86e-81

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  13 GHSIPVLGFGT-----YATEEHLKKKSMESTKIAIDVGFCHIDCSHLYQNEEEIGQAIlskiEDGTVKREDIFYTSKLws 87
Cdd:cd19120   1 GSKIPAIAFGTgtawyKSGDDDIQRDLVDSVKLALKAGFRHIDTAEMYGNEKEVGEAL----KESGVPREDLFITTKV-- 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  88 tSHRPELVRPSLENSLRKLNLDYVDLYLIHFPVSLKPGnellpkdehgnlifdTVDLCDTWEAMEKCKDAGLAKSIGVSN 167
Cdd:cd19120  75 -SPGIKDPREALRKSLAKLGVDYVDLYLIHSPFFAKEG---------------GPTLAEAWAELEALKDAGLVRSIGVSN 138

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 168 FNRRQLEMILNKPglKYKPVCNQVECHLYLN--QSKLLAYCKMNDIVLVAYGALGTQRYKycinEDTPVlldDPVLCAMA 245
Cdd:cd19120 139 FRIEDLEELLDTA--KIKPAVNQIEFHPYLYpqQPALLEYCREHGIVVSAYSPLSPLTRD----AGGPL---DPVLEKIA 209

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 19527284 246 KKYKRTPALIALRYQLDRGIVALAKSFNEERIRENMQVFDFQLASDDMKILD 297
Cdd:cd19120 210 EKYGVTPAQVLLRWALQKGIVVVTTSSKEERMKEYLEAFDFELTEEEVEEID 261

AKR_AKR3A1-2

cd19117

AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are ...

3-299

1.44e-80

AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are founding members of aldo-keto reductase family 3 member A1 (AKR3A1) and A2 (AKR3A2), respectively. Gcy1p, also called galactose-inducible crystallin-like protein 1, is a glycerol dehydrogenase involved in glycerol catabolism under microaerobic conditions. It has mRNA binding activity. Ypr1p acts as a 2-methylbutyraldehyde reductase that displays high specific activity towards 2-methylbutyraldehyde, as well as other aldehydes such as hexanal.

Pssm-ID: 381343 [Multi-domain] Cd Length: 284 Bit Score: 246.26 E-value: 1.44e-80

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284   3 SKIQKieLNDGHSIPVLGFGTYATEEHLKKKSMEStkiAIDVGFCHIDCSHLYQNEEEIGQAIlskiEDGTVKREDIFYT 82
Cdd:cd19117   3 SKTFK--LNTGAEIPAVGLGTWQSKPNEVAKAVEA---ALKAGYRHIDTAAIYGNEEEVGQGI----KDSGVPREEIFIT 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  83 SKLWSTSHRPelVRPSLENSLRKLNLDYVDLYLIHFPVSLKP-GNELLPKDEHGNLIFDTV-DLCDTWEAMEKCKDAGLA 160
Cdd:cd19117  74 TKLWCTWHRR--VEEALDQSLKKLGLDYVDLYLMHWPVPLDPdGNDFLFKKDDGTKDHEPDwDFIKTWELMQKLPATGKV 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 161 KSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHLYLNQSKLLAYCKMNDIVLVAYGALGTQrykycineDTPvLLDDPV 240
Cdd:cd19117 152 KAIGVSNFSIKNLEKLLASPSAKIVPAVNQIELHPLLPQPKLVDFCKSKGIHATAYSPLGST--------NAP-LLKEPV 222

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 19527284 241 LCAMAKKYKRTPALIALRYQLDRGIVALAKSFNEERIRENMQVfdFQLASDDMKILDGL 299
Cdd:cd19117 223 IIKIAKKHGKTPAQVIISWGLQRGYSVLPKSVTPSRIESNFKL--FTLSDEEFKEIDEL 279

AKR_AKR2B1-10

cd19113

AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent ...

8-305

4.49e-80

AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent D-xylose reductase (XR) from Pichia stipites, Kluyveromyces lactis, Pachysolen tannophilus, Candida tropicalis, and Candida tenuis, Gre3p from Saccharomyces cerevisiae, XR from Candida tropicalis, Pichia guilliermondii, Debaryomyces hansenli, and Debaryomyces nepalensis, which correspond to aldo-keto reductase family 2 member B1-B10 (AKR2B1-10), respectively. XR (EC1.1.1.307) catalyzes the NAD(P)H dependent reduction of xylose to xylitol.

Pssm-ID: 381339 [Multi-domain] Cd Length: 310 Bit Score: 245.82 E-value: 4.49e-80

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284   8 IELNDGHSIPVLGFGTYATEehlKKKSMESTKIAIDVGFCHIDCSHLYQNEEEIGQAILSKIEDGTVKREDIFYTSKLWS 87
Cdd:cd19113   3 IKLNSGYKMPSVGFGCWKLD---NATAADQIYQAIKAGYRLFDGAEDYGNEKEVGEGVNRAIDEGLVKREELFLTSKLWN 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  88 TSHRPELVRPSLENSLRKLNLDYVDLYLIHFPVSLKPgnelLPKDEH----------GNLIFDTVDLCDTWEAMEKCKDA 157
Cdd:cd19113  80 NFHDPKNVETALNKTLSDLKLDYVDLFLIHFPIAFKF----VPIEEKyppgfycgdgDNFVYEDVPILDTWKALEKLVDA 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 158 GLAKSIGVSNFNRRQLEMILNkpGLKYKPVCNQVECHLYLNQSKLLAYCKMNDIVLVAYGALGTQRYKYCINE---DTPV 234
Cdd:cd19113 156 GKIKSIGVSNFPGALILDLLR--GATIKPAVLQIEHHPYLQQPKLIEYAQKAGITITAYSSFGPQSFVELNQGralNTPT 233

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19527284 235 LLDDPVLCAMAKKYKRTPALIALRYQLDRGIVALAKSFNEERIRENMQVFDFQLASDDMKILDGLDRNLRY 305
Cdd:cd19113 234 LFEHDTIKSIAAKHNKTPAQVLLRWATQRGIAVIPKSNLPERLLQNLSVNDFDLTKEDFEEIAKLDIGLRF 304

AKR_GlAR-like

cd19128

Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), ...

17-299

4.04e-79

Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), also called aldehyde reductase, is the prototype of this family. It catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.

Pssm-ID: 381354 [Multi-domain] Cd Length: 277 Bit Score: 242.43 E-value: 4.04e-79

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  17 PVLGFGTYATEEHLKKksmESTKIAIDVGFCHIDCSHLYQNEEEIGQAILSKIEDGTVKREDIFYTSKLWSTSHRPELVR 96
Cdd:cd19128   2 PRLGFGTYKITESESK---EAVKNAIKAGYRHIDCAYYYGNEAFIGIAFSEIFKDGGVKREDLFITSKLWPTMHQPENVK 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  97 PSLENSLRKLNLDYVDLYLIHFPVSLKPGNELLPKDEHGNLIFDTVDLCDTWEAMEKCKDAGLAKSIGVSNFNRRQLEMI 176
Cdd:cd19128  79 EQLLITLQDLQLEYLDLFLIHWPLAFDMDTDGDPRDDNQIQSLSKKPLEDTWRAMEQCVDEKLTKNIGVSNYSTKLLTDL 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 177 LNKpgLKYKPVCNQVECHLYLNQSKLLAYCKMNDIVLVAYGALGtQRYKYcineDTPVLLDDPVLCAMAKKYKRTPALIA 256
Cdd:cd19128 159 LNY--CKIKPFMNQIECHPYFQNDKLIKFCIENNIHVTAYRPLG-GSYGD----GNLTFLNDSELKALATKYNTTPPQVI 231

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 19527284 257 LRYQLDR---GIVALAKSFNEERIRENMQVFDFQLASDDMKILDGL 299
Cdd:cd19128 232 IAWHLQKwpkNYSVIPKSANKSRCQQNFDINDLALTKEDMDAINTL 277

AKR_AKR5F1

cd19133

the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid ...

8-300

4.11e-79

the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid reductase (2,5-DKG reductase) is a founding member of aldo-keto reductase family 5 member F1 (AKR5F1). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).

Pssm-ID: 381359 [Multi-domain] Cd Length: 255 Bit Score: 241.32 E-value: 4.11e-79

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284   8 IELNDGHSIPVLGFGTYATEEhlKKKSMESTKIAIDVGFCHIDCSHLYQNEEEIGQAIlskiEDGTVKREDIFYTSKLWS 87
Cdd:cd19133   1 VTLNNGVEMPILGFGVFQIPD--PEECERAVLEAIKAGYRLIDTAAAYGNEEAVGRAI----KKSGIPREELFITTKLWI 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  88 TSHRPELVRPSLENSLRKLNLDYVDLYLIHFPVSlkpgnellpkDEHGnlifdtvdlcdTWEAMEKCKDAGLAKSIGVSN 167
Cdd:cd19133  75 QDAGYEKAKKAFERSLKRLGLDYLDLYLIHQPFG----------DVYG-----------AWRAMEELYKEGKIRAIGVSN 133

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 168 FNRRQLEMILnkPGLKYKPVCNQVECHLYLNQSKLLAYCKMNDIVLVAYGALGtqrykycinEDTPVLLDDPVLCAMAKK 247
Cdd:cd19133 134 FYPDRLVDLI--LHNEVKPAVNQIETHPFNQQIEAVEFLKKYGVQIEAWGPFA---------EGRNNLFENPVLTEIAEK 202

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 19527284 248 YKRTPALIALRYQLDRGIVALAKSFNEERIRENMQVFDFQLASDDMKILDGLD 300
Cdd:cd19133 203 YGKSVAQVILRWLIQRGIVVIPKSVRPERIAENFDIFDFELSDEDMEAIAALD 255

AKR_AKR3F3

cd19140

Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin ...

13-299

9.34e-79

Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.

Pssm-ID: 381366 [Multi-domain] Cd Length: 253 Bit Score: 240.62 E-value: 9.34e-79

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  13 GHSIPVLGFGTYATEEhlkKKSMESTKIAIDVGFCHIDCSHLYQNEEEIGQAIlskiEDGTVKREDIFYTSKLWSTSHRP 92
Cdd:cd19140   5 GVRIPALGLGTYPLTG---EECTRAVEHALELGYRHIDTAQMYGNEAQVGEAI----AASGVPRDELFLTTKVWPDNYSP 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  93 ELVRPSLENSLRKLNLDYVDLYLIHFPvslkpgnellPKDehgnlifdtVDLCDTWEAMEKCKDAGLAKSIGVSNFNRRQ 172
Cdd:cd19140  78 DDFLASVEESLRKLRTDYVDLLLLHWP----------NKD---------VPLAETLGALNEAQEAGLARHIGVSNFTVAL 138

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 173 LEMILNKPGLKYkpVCNQVECHLYLNQSKLLAYCKMNDIVLVAYGALGTQRykycinedtpvLLDDPVLCAMAKKYKRTP 252
Cdd:cd19140 139 LREAVELSEAPL--FTNQVEYHPYLDQRKLLDAAREHGIALTAYSPLARGE-----------VLKDPVLQEIGRKHGKTP 205

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 19527284 253 ALIALRYQLDR-GIVALAKSFNEERIRENMQVFDFQLASDDMKILDGL 299
Cdd:cd19140 206 AQVALRWLLQQeGVAAIPKATNPERLEENLDIFDFTLSDEEMARIAAL 253

AKR_AKR5G1-3

cd19157

AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), ...

7-307

1.15e-78

AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase are founding members of aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.

Pssm-ID: 381383 [Multi-domain] Cd Length: 265 Bit Score: 240.76 E-value: 1.15e-78

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284   7 KIELNDGHSIPVLGFGTYATEEhlKKKSMESTKIAIDVGFCHIDCSHLYQNEEEIGQAIlskiEDGTVKREDIFYTSKLW 86
Cdd:cd19157   1 TVTLNNGVKMPWLGLGVFKVEE--GSEVVNAVKTALKNGYRSIDTAAIYGNEEGVGKGI----KESGIPREELFITSKVW 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  87 STSHRPELVRPSLENSLRKLNLDYVDLYLIHFPVSLKpgnellpkdehgnlifdtvdLCDTWEAMEKCKDAGLAKSIGVS 166
Cdd:cd19157  75 NADQGYDSTLKAFEASLERLGLDYLDLYLIHWPVKGK--------------------YKETWKALEKLYKDGRVRAIGVS 134

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 167 NFNRRQLEMILNKPglKYKPVCNQVECHLYLNQSKLLAYCKMNDIVLVAYGALGTQRykycinedtpvLLDDPVLCAMAK 246
Cdd:cd19157 135 NFQVHHLEDLLADA--EIVPMVNQVEFHPRLTQKELRDYCKKQGIQLEAWSPLMQGQ-----------LLDNPVLKEIAE 201

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19527284 247 KYKRTPALIALRYQLDRGIVALAKSFNEERIRENMQVFDFQLASDDMKILDGLDRNLRYFP 307
Cdd:cd19157 202 KYNKSVAQVILRWDLQNGVVTIPKSIKEHRIIENADVFDFELSQEDMDKIDALNENLRVGP 262

AKR_AKR2D1

cd19115

AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose ...

6-305

3.48e-78

AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose reductase xyl1 (XR, EC 1.1.1.307) is a founding member of aldo-keto reductase family 2 member D1 (AKR2D1). It catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol in a NAD(P)H dependent manner.

Pssm-ID: 381341 [Multi-domain] Cd Length: 311 Bit Score: 241.17 E-value: 3.48e-78

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284   6 QKIELNDGHSIPVLGFGTYATEehlKKKSMESTKIAIDVGFCHIDCSHLYQNEEEIGQAILSKIEDGTVKREDIFYTSKL 85
Cdd:cd19115   3 PTVKLNSGYDMPLVGFGLWKVN---NDTCADQVYNAIKAGYRLFDGACDYGNEVEAGQGVARAIKEGIVKREDLFIVSKL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  86 WSTSHRPELVRPSLENSLRKLNLDYVDLYLIHFPVSLK---PGNELLP--KDEHGNLIFDTVDLCDTWEAMEKCKDAGLA 160
Cdd:cd19115  80 WNTFHDGERVEPICRKQLADWGIDYFDLFLIHFPIALKyvdPAVRYPPgwFYDGKKVEFSNAPIQETWTAMEKLVDKGLA 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 161 KSIGVSNFNrRQLEMILnkpgLKY---KPVCNQVECHLYLNQSKLLAYCKMNDIVLVAYGALGTQRYKYCIN---EDTPV 234
Cdd:cd19115 160 RSIGVSNFS-AQLLMDL----LRYariRPATLQIEHHPYLTQPRLVKYAQKEGIAVTAYSSFGPQSFLELDLpgaKDTPP 234

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19527284 235 LLDDPVLCAMAKKYKRTPALIALRYQLDRGIVALAKSFNEERIRENMQVFDFQLASDDMKILDGLDRNLRY 305
Cdd:cd19115 235 LFEHDVIKSIAEKHGKTPAQVLLRWATQRGIAVIPKSNNPKRLAQNLDVTGFDLEAEEIKAISALDIGLRF 305

AKR_AKR5A_5G

cd19126

AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes ...

8-300

7.32e-77

AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes prostaglandin F2-alpha synthase (PGFS) from Leishmania major (AKR5A1) and Trypanosoma brucei (AKR5A2). PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity for synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde. The AKR5G family of AKR includes Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase, which corresponds to aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.

Pssm-ID: 381352 [Multi-domain] Cd Length: 254 Bit Score: 235.79 E-value: 7.32e-77

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284   8 IELNDGHSIPVLGFGTYATEEhlKKKSMESTKIAIDVGFCHIDCSHLYQNEEEIGQAIlskiEDGTVKREDIFYTSKLWS 87
Cdd:cd19126   1 VTLNNGTRMPWLGLGVFQTPD--GDETERAVQTALENGYRSIDTAAIYKNEEGVGEAI----RESGVPREELFVTTKLWN 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  88 TSHRPELVRPSLENSLRKLNLDYVDLYLIHFPVSLKpgnellpkdehgnlifdtvdLCDTWEAMEKCKDAGLAKSIGVSN 167
Cdd:cd19126  75 DDQRARRTEDAFQESLDRLGLDYVDLYLIHWPGKDK--------------------FIDTWKALEKLYASGKVKAIGVSN 134

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 168 FNRRQLEMILNKPglKYKPVCNQVECHLYLNQSKLLAYCKMNDIVLVAYGALGTQRykycinedtpvLLDDPVLCAMAKK 247
Cdd:cd19126 135 FQEHHLEELLAHA--DVVPAVNQVEFHPYLTQKELRGYCKSKGIVVEAWSPLGQGG-----------LLSNPVLAAIGEK 201

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 19527284 248 YKRTPALIALRYQLDRGIVALAKSFNEERIRENMQVFDFQLASDDMKILDGLD 300
Cdd:cd19126 202 YGKSAAQVVLRWDIQHGVVTIPKSVHASRIKENADIFDFELSEDDMTAIDALN 254

AKR_AKR5D1_E1

cd19132

AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B ...

10-301

2.28e-76

AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B (DkgB) from Corynebacterium sp. and 2,5-diketo-D-gluconic acid reductase Zymomonas mobilis are founding members of aldo-keto reductase family 5 member D1 (AKR5D1) and E1 (AKR5E1), respectively. DkgB (EC 1.1.1.274), also called 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).

Pssm-ID: 381358 [Multi-domain] Cd Length: 255 Bit Score: 234.47 E-value: 2.28e-76

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  10 LNDGHSIPVLGFGTYATEEHLKKKSMEStkiAIDVGFCHIDCSHLYQNEEEIGQAIlskiEDGTVKREDIFYTSKLWSTS 89
Cdd:cd19132   1 LNDGTQIPAIGFGTYPLKGDEGVEAVVA---ALQAGYRLLDTAFNYENEGAVGEAV----RRSGVPREELFVTTKLPGRH 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  90 HRPELVRPSLENSLRKLNLDYVDLYLIHFPvslkpgnelLPKdehgnlifdtVDL-CDTWEAMEKCKDAGLAKSIGVSNF 168
Cdd:cd19132  74 HGYEEALRTIEESLYRLGLDYVDLYLIHWP---------NPS----------RDLyVEAWQALIEAREEGLVRSIGVSNF 134

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 169 NRRQLEMILNKPGLKykPVCNQVECHLYLNQSKLLAYCKMNDIVLVAYGALGTqrykyciNEDtpvLLDDPVLCAMAKKY 248
Cdd:cd19132 135 LPEHLDRLIDETGVT--PAVNQIELHPYFPQAEQRAYHREHGIVTQSWSPLGR-------GSG---LLDEPVIKAIAEKH 202

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 19527284 249 KRTPALIALRYQLDRGIVALAKSFNEERIRENMQVFDFQLASDDMKILDGLDR 301
Cdd:cd19132 203 GKTPAQVVLRWHVQLGVVPIPKSANPERQRENLAIFDFELSDEDMAAIAALDR 255

AKR_AKR3D1

cd19121

AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, ...

10-299

8.98e-76

AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, EC 1.1.1.365), also called D-galacturonic acid reductase, or GalUR, is a founding member of aldo-keto reductase family 3 member D1 (AKR3D1). It mediates the reduction of D-galacturonate to L-galactonate, the first step in D-galacturonate catabolic process. It also has activity with D-glucuronate and DL-glyceraldehyde. Its activity is seen only with NADPH and not with NADH.

Pssm-ID: 381347 [Multi-domain] Cd Length: 279 Bit Score: 233.96 E-value: 8.98e-76

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  10 LNDGHSIPVLGFGTYATEEHLKKKSMEStkiAIDVGFCHIDCSHLYQNEEEIGQAILSKIeDGTVKREDIFYTSKLWSTS 89
Cdd:cd19121   6 LNTGASIPAVGLGTWQAKAGEVKAAVAH---ALKIGYRHIDGALCYQNEDEVGEGIKEAI-AGGVKREDLFVTTKLWSTY 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  90 H-RPELvrpSLENSLRKLNLDYVDLYLIHFPVSLKP-GN-ELLPKDEHGNLIFD-TVDLCDTWEAMEKCKDAGLAKSIGV 165
Cdd:cd19121  82 HrRVEL---CLDRSLKSLGLDYVDLYLVHWPVLLNPnGNhDLFPTLPDGSRDLDwDWNHVDTWKQMEKVLKTGKTKAIGV 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 166 SNFNRRQLEMILnkPGLKYKPVCNQVECHLYLNQSKLLAYCKMNDIVLVAYGALGTQrykycineDTPVLLDDPVLcAMA 245
Cdd:cd19121 159 SNYSIPYLEELL--KHATVVPAVNQVENHPYLPQQELVDFCKEKGILIEAYSPLGST--------GSPLISDEPVV-EIA 227

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 19527284 246 KKYKRTPALIALRYQLDRGIVALAKSFNEERIRENMQVFDFQlaSDDMKILDGL 299
Cdd:cd19121 228 KKHNVGPGTVLISYQVARGAVVLPKSVTPDRIKSNLEIIDLD--DEDMNKLNDI 279

AKR_CeZK1290-like

cd19135

Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the ...

4-299

9.79e-74

Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.

Pssm-ID: 381361 [Multi-domain] Cd Length: 265 Bit Score: 227.98 E-value: 9.79e-74

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284   4 KIQKIELNDGHSIPVLGFGTyateEHLKKKSMESTKIAI-DVGFCHIDCSHLYQNEEEIGQAILskiEDGtVKREDIFYT 82
Cdd:cd19135   1 GTPTVRLSNGVEMPILGLGT----SHSGGYSHEAVVYALkECGYRHIDTAKRYGCEELLGKAIK---ESG-VPREDLFLT 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  83 SKLWSTSHRPELVRPSLENSLRKLNLDYVDLYLIHFPVSLKPGNEllPKDEhgnlifdtvdLCDTWEAMEKCKDAGLAKS 162
Cdd:cd19135  73 TKLWPSDYGYESTKQAFEASLKRLGVDYLDLYLLHWPDCPSSGKN--VKET----------RAETWRALEELYDEGLCRA 140

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 163 IGVSNFNRRQLEMILNKPGLKykPVCNQVECHLYLNQSKLLAYCKMNDIVLVAYGALGTQRYkycinedtpvlLDDPVLC 242
Cdd:cd19135 141 IGVSNFLIEHLEQLLEDCSVV--PHVNQVEFHPFQNPVELIEYCRDNNIVFEGYCPLAKGKA-----------LEEPTVT 207

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 19527284 243 AMAKKYKRTPALIALRYQLDRGIVALAKSFNEERIRENMQVFDFQLASDDMKILDGL 299
Cdd:cd19135 208 ELAKKYQKTPAQILIRWSIQNGVVTIPKSTKEERIKENCQVFDFSLSEEDMATLDSL 264

AKR_AKR5A1_2

cd19156

AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from ...

8-307

1.46e-71

AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from Leishmania major and Trypanosoma brucei are founding members of aldo-keto reductase family 5 member A1 (AKR5A1) and A2 (AKR5A2), respectively. PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.

Pssm-ID: 381382 [Multi-domain] Cd Length: 266 Bit Score: 222.78 E-value: 1.46e-71

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284   8 IELNDGHSIPVLGFGTYATEEhlKKKSMESTKIAIDVGFCHIDCSHLYQNEEEIGQAIlskiEDGTVKREDIFYTSKLWS 87
Cdd:cd19156   1 VKLANGVEMPRLGLGVWRVQD--GAEAENAVKWAIEAGYRHIDTAAIYKNEEGVGQGI----RESGVPREEVFVTTKLWN 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  88 TSHRPELVRPSLENSLRKLNLDYVDLYLIHFPVSLKpgnellpkdehgnlifdtvdLCDTWEAMEKCKDAGLAKSIGVSN 167
Cdd:cd19156  75 SDQGYESTLAAFEESLEKLGLDYVDLYLIHWPVKGK--------------------FKDTWKAFEKLYKEKKVRAIGVSN 134

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 168 FNRRQLEMILNKpgLKYKPVCNQVECHLYLNQSKLLAYCKMNDIVLVAYGALGTQRykycinedtpvLLDDPVLCAMAKK 247
Cdd:cd19156 135 FHEHHLEELLKS--CKVAPMVNQIELHPLLTQEPLRKFCKEKNIAVEAWSPLGQGK-----------LLSNPVLKAIGKK 201

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 248 YKRTPALIALRYQLDRGIVALAKSFNEERIRENMQVFDFQLASDDMKILDGLDRNLRYFP 307
Cdd:cd19156 202 YGKSAAQVIIRWDIQHGIITIPKSVHEERIQENFDVFDFELTAEEIRQIDGLNTDHRYGP 261

AKR_AKR5B1

cd19127

AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) ...

8-300

1.85e-70

AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) is a founding member of the aldo-keto reductase family 5 member B1 (AKR5B1). M6DH (EC 1.1.1.218), also called naloxone reductase, oxidizes the C-6 hydroxy group of morphine and codeine.

Pssm-ID: 381353 [Multi-domain] Cd Length: 268 Bit Score: 219.97 E-value: 1.85e-70

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284   8 IELNDGHSIPVLGFGTYAT--EEhlkkkSMESTKIAIDVGFCHIDCSHLYQNEEEIGQAIlskiEDGTVKREDIFYTSKL 85
Cdd:cd19127   1 ITLNNGVEMPALGLGVFQTppEE-----TADAVATALADGYRLIDTAAAYGNEREVGEGI----RRSGVDRSDIFVTTKL 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  86 WSTSHRPELVRPSLENSLRKLNLDYVDLYLIHFPVSlkpgnellpkdehgNLIFDTVDlcdTWEAMEKCKDAGLAKSIGV 165
Cdd:cd19127  72 WISDYGYDKALRGFDASLRRLGLDYVDLYLLHWPVP--------------NDFDRTIQ---AYKALEKLLAEGRVRAIGV 134

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 166 SNFNRRQLEMILNKPGLKykPVCNQVECHLYLNQSKLLAYCKMNDIVLVAYGALG-TQRYKYCINEDTPVLLDDPVLCAM 244
Cdd:cd19127 135 SNFTPEHLERLIDATTVV--PAVNQVELHPYFSQKDLRAFHRRLGIVTQAWSPIGgVMRYGASGPTGPGDVLQDPTITGL 212

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 19527284 245 AKKYKRTPALIALRYQLDRGIVALAKSFNEERIRENMQVFDFQLASDDMKILDGLD 300
Cdd:cd19127 213 AEKYGKTPAQIVLRWHLQNGVSAIPKSVHPERIAENIDIFDFALSAEDMAAIDALD 268

AKR_AKR2C1

cd19114

AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent ...

13-305

1.42e-69

AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent 4-dihydromethyl-trisporate dehydrogenase (TDH), also called 4-dihydromethyltrisporate dehydrogenase, or 4-dihydromethyl-TA dehydrogenase, is a founding member of aldo-keto reductase family 2 member C1 (AKR2C1). It is involved in the biosynthesis of trisporic acid, the sexual hormone of zygomycetes, which induces the first steps of zygophore development. TDH catalyzes the NADP-dependent oxidation of (+) mating-type specific precursor 4-dihydromethyl-trisporate to methyl-trisporate.

Pssm-ID: 381340 [Multi-domain] Cd Length: 302 Bit Score: 218.58 E-value: 1.42e-69

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  13 GHSIPVLGFGTYATEehlKKKSMESTKIAIDVGFCHIDCSHLYQNEEEIGQAILSKIEDGTVKREDIFYTSKLWSTSHRP 92
Cdd:cd19114   1 GDKMPLVGFGTAKIK---ANETEEVIYNAIKVGYRLIDGALLYGNEAEVGRGIRKAIQEGLVKREDLFIVTKLWNNFHGK 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  93 ELVRPSLENSLRKLNLDYVDLYLIHFPVSLK---PGNELLPKDEHGNLI---FDTVDLCDTWEAMEKCKDAGLAKSIGVS 166
Cdd:cd19114  78 DHVREAFDRQLKDYGLDYIDLYLIHFPIPAAyvdPAENYPFLWKDKELKkfpLEQSPMQECWREMEKLVDAGLVRNIGIA 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 167 NFNrrqLEMILNKpgLKY---KPVCNQVECHLYLNQSKLLAYCKMNDIVLVAYGALGTQRYKYCINED---TPvLLDDPV 240
Cdd:cd19114 158 NFN---VQLILDL--LTYakiKPAVLQIEHHPYLQQKRLIDWAKKQGIQITAYSSFGNAVYTKVTKHLkhfTN-LLEHPV 231

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19527284 241 LCAMAKKYKRTPALIALRYQLDRGIVALAKSFNEERIRENMQVFDFQLASDDMKILDGLDRNLRY 305
Cdd:cd19114 232 VKKLADKHKRDTGQVLLRWAVQRNITVIPKSVNVERMKTNLDITSYKLDEEDMEALYELEANARF 296

AKR_AKR5C1

cd19130

Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; ...

7-300

2.41e-65

Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; Corynebacterium sp. DkgA is a founding member of aldo-keto reductase family 5 member C1 (AKR5C1). DkgA (EC 1.1.1.346), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). 5-keto-D-fructose and dihydroxyacetone can also serve as substrates.

Pssm-ID: 381356 [Multi-domain] Cd Length: 256 Bit Score: 206.30 E-value: 2.41e-65

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284   7 KIELNDGHSIPVLGFGTYATEEhlkKKSMESTKIAIDVGFCHIDCSHLYQNEEEIGQAILSKiedgTVKREDIFYTSKLW 86
Cdd:cd19130   1 SIVLNDGNSIPQLGYGVFKVPP---ADTQRAVATALEVGYRHIDTAAIYGNEEGVGAAIAAS----GIPRDELFVTTKLW 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  87 STSHRPELVRPSLENSLRKLNLDYVDLYLIHFPVSLKpgnellpkdehGNLIfdtvdlcDTWEAMEKCKDAGLAKSIGVS 166
Cdd:cd19130  74 NDRHDGDEPAAAFAESLAKLGLDQVDLYLVHWPTPAA-----------GNYV-------HTWEAMIELRAAGRTRSIGVS 135

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 167 NFNRRQLEMILNKPGLKykPVCNQVECHLYLNQSKLLAYCKMNDIVLVAYGALGTQRykycinedtpvLLDDPVLCAMAK 246
Cdd:cd19130 136 NFLPPHLERIVAATGVV--PAVNQIELHPAYQQRTIRDWAQAHDVKIEAWSPLGQGK-----------LLGDPPVGAIAA 202

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 19527284 247 KYKRTPALIALRYQLDRGIVALAKSFNEERIRENMQVFDFQLASDDMKILDGLD 300
Cdd:cd19130 203 AHGKTPAQIVLRWHLQKGHVVFPKSVRRERMEDNLDVFDFDLTDTEIAAIDALD 256

AKR_AKR3C1

cd19119

Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar ...

8-301

4.27e-65

Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar proteins; Saccharomyces cerevisiae Ara1p (EC 1.1.1.117), also called D-arabinose 1-dehydrogenase (NAD(P)(+)), is a founding members of aldo-keto reductase family 3 member C1 (AKR3C1). It catalyzes the oxidation of D-arabinose, L-xylose, L-fucose, and L-galactose in the presence of NADP(+).

Pssm-ID: 381345 [Multi-domain] Cd Length: 294 Bit Score: 206.96 E-value: 4.27e-65

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284   8 IELNDGHSIPVLGFGTYATEEHLKKKSmESTKIAIDVGFCHIDCSHLYQNEEEIGQAILSKIEDGTVKREDIFYTSKLWS 87
Cdd:cd19119   4 FKLNTGASIPALGLGTASPHEDRAEVK-EAVEAAIKEGYRHIDTAYAYETEDFVGEAIKRAIDDGSIKREELFITTKVWP 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  88 TSHRPelVRPSLENSLRKLNLDYVDLYLIHFPVSLKPGNE-----LLPKDEHGNLIF-DTVDLCDTWEAMEKCKDAGLAK 161
Cdd:cd19119  83 TFYDE--VERSLDESLKALGLDYVDLLLVHWPVCFEKDSDdsgkpFTPVNDDGKTRYaASGDHITTYKQLEKIYLDGRAK 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 162 SIGVSNFNRRQLEMILNKpgLKYKPVCNQVECHLYLNQSKLLAYCKMNDIVLVAYGALGTQRYKycinedtpvLLDDPVL 241
Cdd:cd19119 161 AIGVSNYSIVYLERLIKE--CKVVPAVNQVELHPHLPQMDLRDFCFKHGILVTAYSPLGSHGAP---------NLKNPLV 229

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 242 CAMAKKYKRTPALIALRYQLDRGIVALAKSFNEERIRENMQVfdFQLASDDMKILDGLDR 301
Cdd:cd19119 230 KKIAEKYNVSTGDILISYHVRQGVIVLPKSLKPVRIVSNGKI--VSLTKEDLQKLDDIGE 287

AKR_AKR3F2

cd19139

Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; ...

16-299

1.91e-63

Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).

Pssm-ID: 381365 [Multi-domain] Cd Length: 248 Bit Score: 201.04 E-value: 1.91e-63

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  16 IPVLGFGTYateeHLKKKS-MESTKIAIDVGFCHIDCSHLYQNEEEIGQAIlskiEDGTVKREDIFYTSKLWSTSHRPEL 94
Cdd:cd19139   1 IPAFGLGTF----RLKDDVvIDSVRTALELGYRHIDTAQIYDNEAAVGQAI----AESGVPRDELFITTKIWIDNLSKDK 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  95 VRPSLENSLRKLNLDYVDLYLIHFPVslkpgnellPKDEhgnlifdtVDLCDTWEAMEKCKDAGLAKSIGVSNFNRRQLE 174
Cdd:cd19139  73 LLPSLEESLEKLRTDYVDLTLIHWPS---------PNDE--------VPVEEYIGALAEAKEQGLTRHIGVSNFTIALLD 135

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 175 MILNKPGlKYKPVCNQVECHLYLNQSKLLAYCKMNDIVLVAYGALGTQRykycinedtpvLLDDPVLCAMAKKYKRTPAL 254
Cdd:cd19139 136 EAIAVVG-AGAIATNQIELSPYLQNRKLVAHCKQHGIHVTSYMTLAYGK-----------VLDDPVLAAIAERHGATPAQ 203

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 19527284 255 IALRYQLDRGIVALAKSFNEERIRENMQVFDFQLASDDMKILDGL 299
Cdd:cd19139 204 IALAWAMARGYAVIPSSTKREHLRSNLLALDLTLDADDMAAIAAL 248

AKR_AKR3E1

cd19122

AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol ...

10-286

7.48e-63

AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol 2-dehydrogenase (GLD2, EC 1.1.1.156), also called dihydroxyacetone reductase, is a founding member of aldo-keto reductase family 3 member E1 (AKR3E1). It acts as a glycerol oxidoreductase probably involved in glycerol synthesis.

Pssm-ID: 381348 [Multi-domain] Cd Length: 291 Bit Score: 201.31 E-value: 7.48e-63

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  10 LNDGHSIPVLGFGTYATEEHlKKKSMESTKIAIDVGFCHIDCSHLYQNEEEIGQAILSKI-EDGTVKREDIFYTSKLWST 88
Cdd:cd19122   3 LNNGVKIPAVGFGTFANEGA-KGETYAAVTKALDVGYRHLDCAWFYLNEDEVGDAVRDFLkENPSVKREDLFICTKVWNH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  89 SHRPELVRPSLENSLRKLNLDYVDLYLIHFPVSLKPGNELLPK-DEHGNLIFDTvDLCD----TWEAMEKCKDAGLAKSI 163
Cdd:cd19122  82 LHEPEDVKWSIDNSLKNLKLDYIDLFLVHWPIAAEKNDQRSPKlGPDGKYVILK-DLTEnpepTWRAMEEIYESGKAKAI 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 164 GVSNFNRRQLEMILNKPglKYKPVCNQVECHLYLNQSKLLAYCKMNDIVLVAYGALGTQRYKYCINEDTPvllDDPVLCA 243
Cdd:cd19122 161 GVSNWTIPGLKKLLSFA--KVKPHVNQIEIHPFLPNEELVDYCFSNDILPEAYSPLGSQNQVPSTGERVS---ENPTLNE 235

                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 19527284 244 MAKKYKRTPALIALRYQLDRGIVALAKSFNEERIRENMQVFDF 286
Cdd:cd19122 236 VAEKGGYSLAQVLIAWGLRRGYVVLPKSSTPSRIESNFKSIEL 278

dkgA

PRK11565

2,5-didehydrogluconate reductase DkgA;

8-307

2.14e-62

2,5-didehydrogluconate reductase DkgA;

Pssm-ID: 183203 [Multi-domain] Cd Length: 275 Bit Score: 199.53 E-value: 2.14e-62

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284    8 IELNDGHSIPVLGFGTYateehlkKKSMESTKIAI----DVGFCHIDCSHLYQNEEEIGQAIlskiEDGTVKREDIFYTS 83
Cdd:PRK11565   7 IKLQDGNVMPQLGLGVW-------QASNEEVITAIhkalEVGYRSIDTAAIYKNEEGVGKAL----KEASVAREELFITT 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284   84 KLWSTSHRPelVRPSLENSLRKLNLDYVDLYLIHFPVslkpgnellPKDEHgnlifdtvdLCDTWEAMEKCKDAGLAKSI 163
Cdd:PRK11565  76 KLWNDDHKR--PREALEESLKKLQLDYVDLYLMHWPV---------PAIDH---------YVEAWKGMIELQKEGLIKSI 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  164 GVSNFNRRQLEMILNKPGLKykPVCNQVECHLYLNQSKLLAYCKMNDIVL-----VAYGALGtqrykycinedtpvLLDD 238
Cdd:PRK11565 136 GVCNFQIHHLQRLIDETGVT--PVINQIELHPLMQQRQLHAWNATHKIQTeswspLAQGGKG--------------VFDQ 199

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19527284  239 PVLCAMAKKYKRTPALIALRYQLDRGIVALAKSFNEERIRENMQVFDFQLASDDMKILDGLDRNLRYFP 307
Cdd:PRK11565 200 KVIRDLADKYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVFDFRLDKDELGEIAKLDQGKRLGP 268

AKR_AKR5H1

cd19134

AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding ...

8-305

2.93e-62

AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding member of aldo-keto reductase family 5 member H1 (AKR5H1). It is a NADPH-dependent aldo-keto reductase that reduces methylglyoxal and phenylglyoxal.

Pssm-ID: 381360 [Multi-domain] Cd Length: 263 Bit Score: 198.54 E-value: 2.93e-62

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284   8 IELNDGHSIPVLGFGTYATEEHLKKKSMEStkiAIDVGFCHIDCSHLYQNEEEIGQAILSKiedgTVKREDIFYTSKLWS 87
Cdd:cd19134   3 VTLNDDNTMPVIGLGVGELSDDEAERSVSA---ALEAGYRLIDTAAAYGNEAAVGRAIAAS----GIPRGELFVTTKLAT 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  88 TSHRPELVRPSLENSLRKLNLDYVDLYLIHFPVSlkpgnellpkdehgnlifDTVDLCDTWEAMEKCKDAGLAKSIGVSN 167
Cdd:cd19134  76 PDQGFTASQAACRASLERLGLDYVDLYLIHWPAG------------------REGKYVDSWGGLMKLREEGLARSIGVSN 137

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 168 FNRRQLEMILNKPGlkYKPVCNQVECHLYLNQSKLLAYCKMNDIVLVAYGALGTQRykycinedtpvLLDDPVLCAMAKK 247
Cdd:cd19134 138 FTAEHLENLIDLTF--FTPAVNQIELHPLLNQAELRKVNAQHGIVTQAYSPLGVGR-----------LLDNPAVTAIAAA 204

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 19527284 248 YKRTPALIALRYQLDRGIVALAKSFNEERIRENMQVFDFQLASDDMKILDGLDRNLRY 305
Cdd:cd19134 205 HGRTPAQVLLRWSLQLGNVVISRSSNPERIASNLDVFDFELTADHMDALDGLDDGTRF 262

AKR_AKR3F1-like

cd19072

Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime ...

13-297

8.76e-62

Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase. Escherichia coli YeaE may act as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.

Pssm-ID: 381298 [Multi-domain] Cd Length: 263 Bit Score: 197.45 E-value: 8.76e-62

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  13 GHSIPVLGFGTYATEEHLK------KKSMESTKIAIDVGFCHIDCSHLYQN---EEEIGQAIlskiedGTVKREDIFYTS 83
Cdd:cd19072   1 GEEVPVLGLGTWGIGGGMSkdysddKKAIEALRYAIELGINLIDTAEMYGGghaEELVGKAI------KGFDREDLFITT 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  84 KLWSTSHRPELVRPSLENSLRKLNLDYVDLYLIHFPVslkpgnellpkdehgnlifDTVDLCDTWEAMEKCKDAGLAKSI 163
Cdd:cd19072  75 KVSPDHLKYDDVIKAAKESLKRLGTDYIDLYLIHWPN-------------------PSIPIEETLRAMEELVEEGKIRYI 135

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 164 GVSNFNRRQLEMILNKPGlKYKPVCNQVECHLYLN--QSKLLAYCKMNDIVLVAYGALgtQRYKYCINEDTPVLLDdpvl 241
Cdd:cd19072 136 GVSNFSLEELEEAQSYLK-KGPIVANQVEYNLFDReeESGLLPYCQKNGIAIIAYSPL--EKGKLSNAKGSPLLDE---- 208

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 19527284 242 caMAKKYKRTPALIALRYQLDR-GIVALAKSFNEERIRENMQVFDFQLASDDMKILD 297
Cdd:cd19072 209 --IAKKYGKTPAQIALNWLISKpNVIAIPKASNIEHLEENAGALGWELSEEDLQRLD 263

Aldo_ket_red

pfam00248

Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ...

19-300

1.73e-60

Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.

Pssm-ID: 425554 [Multi-domain] Cd Length: 290 Bit Score: 194.84 E-value: 1.73e-60

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284    19 LGFGTYATEEHLKKKSMEST----KIAIDVGFCHIDCSHLY---QNEEEIGQAIlskiEDGTVKREDIFYTSKL------ 85
Cdd:pfam00248   1 IGLGTWQLGGGWGPISKEEAlealRAALEAGINFIDTAEVYgdgKSEELLGEAL----KDYPVKRDKVVIATKVpdgdgp 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284    86 WSTSHRPELVRPSLENSLRKLNLDYVDLYLIHFPvslkpgnellpkdehgnliFDTVDLCDTWEAMEKCKDAGLAKSIGV 165
Cdd:pfam00248  77 WPSGGSKENIRKSLEESLKRLGTDYIDLYYLHWP-------------------DPDTPIEETWDALEELKKEGKIRAIGV 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284   166 SNFNRRQLEMILNKPglKYKPVCNQVECHLY--LNQSKLLAYCKMNDIVLVAYGALGTQRYKYCINEDTPV--------- 234
Cdd:pfam00248 138 SNFDAEQIEKALTKG--KIPIVAVQVEYNLLrrRQEEELLEYCKKNGIPLIAYSPLGGGLLTGKYTRDPDKgpgerrrll 215

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19527284   235 -------LLDDPVLCAMAKKYKRTPALIALRY--QLDRGIVALAKSFNEERIRENMQVFDFQLASDDMKILDGLD 300
Cdd:pfam00248 216 kkgtplnLEALEALEEIAKEHGVSPAQVALRWalSKPGVTIPIPGASNPEQLEDNLGALEFPLSDEEVARIDELL 290

dkgB

PRK11172

2,5-didehydrogluconate reductase DkgB;

14-304

7.64e-53

2,5-didehydrogluconate reductase DkgB;

Pssm-ID: 183012 [Multi-domain] Cd Length: 267 Bit Score: 174.44 E-value: 7.64e-53

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284   14 HSIPVLGFGTYateeHLKKKS-MESTKIAIDVGFCHIDCSHLYQNEEEIGQAIlskIEDGtVKREDIFYTSKLWSTSHRP 92
Cdd:PRK11172   1 MSIPAFGLGTF----RLKDQVvIDSVKTALELGYRAIDTAQIYDNEAAVGQAI---AESG-VPRDELFITTKIWIDNLAK 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284   93 ELVRPSLENSLRKLNLDYVDLYLIHFPvslKPGNEllpkdehgnlifdtVDLCDTWEAMEKCKDAGLAKSIGVSNFNRRQ 172
Cdd:PRK11172  73 DKLIPSLKESLQKLRTDYVDLTLIHWP---SPNDE--------------VSVEEFMQALLEAKKQGLTREIGISNFTIAL 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  173 LEMILNKPGlKYKPVCNQVECHLYLNQSKLLAYCKMNDIVLVAYGALGTQRykycinedtpvLLDDPVLCAMAKKYKRTP 252
Cdd:PRK11172 136 MKQAIAAVG-AENIATNQIELSPYLQNRKVVAFAKEHGIHVTSYMTLAYGK-----------VLKDPVIARIAAKHNATP 203

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 19527284  253 ALIALRYQLDRGIVALAKSFNEERIRENMQVFDFQLASDDMKILDGLDRNLR 304
Cdd:PRK11172 204 AQVILAWAMQLGYSVIPSSTKRENLASNLLAQDLQLDAEDMAAIAALDRNGR 255

AKR_AKR3F1

cd19137

Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding ...

13-297

1.14e-51

Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase.

Pssm-ID: 381363 [Multi-domain] Cd Length: 260 Bit Score: 171.21 E-value: 1.14e-51

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  13 GHSIPVLGFGT-----YATEEHLKKKSM-ESTKIAIDVGFCHIDCSHLY---QNEEEIGQAILSkiedgtVKREDIFYTS 83
Cdd:cd19137   1 GEKIPALGLGTwgiggFLTPDYSRDEEMvELLKTAIELGYTHIDTAEMYgggHTEELVGKAIKD------FPREDLFIVT 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  84 KLWSTSHRPELVRPSLENSLRKLNLDYVDLYLIHFPvslkpgNELLPKDEhgnlifdtvdlcdTWEAMEKCKDAGLAKSI 163
Cdd:cd19137  75 KVWPTNLRYDDLLRSLQNSLRRLDTDYIDLYLIHWP------NPNIPLEE-------------TLSAMAEGVRQGLIRYI 135

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 164 GVSNFNRRQLEMILNKpgLKYKPVCNQVECHLY---LNQSKLLAYCKMNDIVLVAYGALgtqrykycineDTPVLLDDPV 240
Cdd:cd19137 136 GVSNFNRRLLEEAISK--SQTPIVCNQVKYNLEdrdPERDGLLEYCQKNGITVVAYSPL-----------RRGLEKTNRT 202

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 19527284 241 LCAMAKKYKRTPALIALRYQLDR-GIVALAKSFNEERIRENMQVFDFQLASDDMKILD 297
Cdd:cd19137 203 LEEIAKNYGKTIAQIALAWLIQKpNVVAIPKAGRVEHLKENLKATEIKLSEEEMKLLD 260

AKR_YeaE

cd19138

Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this ...

6-297

1.69e-47

Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this family. It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.

Pssm-ID: 381364 [Multi-domain] Cd Length: 266 Bit Score: 160.49 E-value: 1.69e-47

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284   6 QKIELNDGHSIPVLGFGTYATEEHLKK--KSMESTKIAIDVGFCHIDCSHLYQN---EEEIGQAILSKiedgtvkREDIF 80
Cdd:cd19138   1 RTVTLPDGTKVPALGQGTWYMGEDPAKraQEIEALRAGIDLGMTLIDTAEMYGDggsEELVGEAIRGR-------RDKVF 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  81 YTSKLWSTSHRPELVRPSLENSLRKLNLDYVDLYLIHFPVSlkpgnellpkdehgnlifdtVDLCDTWEAMEKCKDAGLA 160
Cdd:cd19138  74 LVSKVLPSNASRQGTVRACERSLRRLGTDYLDLYLLHWRGG--------------------VPLAETVAAMEELKKEGKI 133

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 161 KSIGVSNFNRRQLEMILNKPGLKyKPVCNQVECHLylnQSK-----LLAYCKMNDIVLVAYGALGTQRykycinEDTPVL 235
Cdd:cd19138 134 RAWGVSNFDTDDMEELWAVPGGG-NCAANQVLYNL---GSRgieydLLPWCREHGVPVMAYSPLAQGG------LLRRGL 203

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19527284 236 LDDPVLCAMAKKYKRTPALIALRYQLDRGIV-ALAKSFNEERIRENMQVFDFQLASDDMKILD 297
Cdd:cd19138 204 LENPTLKEIAARHGATPAQVALAWVLRDGNViAIPKSGSPEHARENAAAADLELTEEDLAELD 266

AKR_AtPLR-like

cd19093

Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR ...

16-297

2.01e-38

Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR (EC 1.1.1.65) is the prototype of this family. It catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+), and is involved in the PLP salvage pathway.

Pssm-ID: 381319 [Multi-domain] Cd Length: 293 Bit Score: 137.74 E-value: 2.01e-38

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  16 IPVLGFGT--------YATEEHLKKKSMESTKIAIDVGFCHIDCSHLY---QNEEEIGQAIlskieDGTVKREDIFYTSK 84
Cdd:cd19093   2 VSPLGLGTwqwgdrlwWGYGEYGDEDLQAAFDAALEAGVNLFDTAEVYgtgRSERLLGRFL-----KELGDRDEVVIATK 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  85 LWSTSHR--PELVRPSLENSLRKLNLDYVDLYLIHFPVSLKPGNELLpkdehgnlifdtvdlcdtWEAMEKCKDAGLAKS 162
Cdd:cd19093  77 FAPLPWRltRRSVVKALKASLERLGLDSIDLYQLHWPGPWYSQIEAL------------------MDGLADAVEEGLVRA 138

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 163 IGVSNFNRRQLEMI---LNKPGlkYKPVCNQVECHL---YLNQSKLLAYCKMNDIVLVAY-----GAL------------ 219
Cdd:cd19093 139 VGVSNYSADQLRRAhkaLKERG--VPLASNQVEYSLlyrDPEQNGLLPACDELGITLIAYsplaqGLLtgkyspenpppg 216

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 220 --GTQRYKYCINEDTPVLLddpVLCAMAKKYKRTPALIALRYQLDRGIVALAKSFNEERIRENMQVFDFQLASDDMKILD 297
Cdd:cd19093 217 grRRLFGRKNLEKVQPLLD---ALEEIAEKYGKTPAQVALNWLIAKGVVPIPGAKNAEQAEENAGALGWRLSEEEVAELD 293

AKR_AKR11B1-like

cd19084

AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called ...

13-297

2.42e-37

AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.

Pssm-ID: 381310 [Multi-domain] Cd Length: 296 Bit Score: 134.96 E-value: 2.42e-37

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  13 GHSIPVLGFGTYA--------TEEhlkKKSMESTKIAIDVGFCHIDCSHLYQN---EEEIGQAIlskiedgTVKREDIFY 81
Cdd:cd19084   1 DLKVSRIGLGTWAiggtwwgeVDD---QESIEAIKAAIDLGINFFDTAPVYGFghsEEILGKAL-------KGRRDDVVI 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  82 TSK---LWSTSH------RPELVRPSLENSLRKLNLDYVDLYLIHFPvslkpgnellpkDEhgnlifdTVDLCDTWEAME 152
Cdd:cd19084  71 ATKcglRWDGGKgvtkdlSPESIRKEVEQSLRRLQTDYIDLYQIHWP------------DP-------NTPIEETAEALE 131

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 153 KCKDAGLAKSIGVSNFNRRQLEMIlnkpgLKY-KPVCNQVECHLyLNQ---SKLLAYCKMNDIVLVAYGALG----TQRY 224
Cdd:cd19084 132 KLKKEGKIRYIGVSNFSVEQLEEA-----RKYgPIVSLQPPYSM-LEReieEELLPYCRENGIGVLPYGPLAqgllTGKY 205

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 225 KYCIN-EDTPVLLDDP---------------VLCAMAKKYKRTPALIALRYQLDR--GIVALAKSFNEERIRENMQVFDF 286
Cdd:cd19084 206 KKEPTfPPDDRRSRFPffrgenfeknleivdKLKEIAEKYGKSLAQLAIAWTLAQpgVTSAIVGAKNPEQLEENAGALDW 285

                       330
                ....*....|.
gi 19527284 287 QLASDDMKILD 297
Cdd:cd19084 286 ELTEEELKEID 296

PdxI

COG0667

Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme ...

11-297

4.07e-35

Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme transport and metabolism, General function prediction only];

Pssm-ID: 440431 [Multi-domain] Cd Length: 316 Bit Score: 129.53 E-value: 4.07e-35

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  11 NDGHSIPVLGFGT--------YATEEhlkkksmESTKI---AIDVGFCHIDCSHLY---QNEEEIGQAIlskiedGTVKR 76
Cdd:COG0667   8 RSGLKVSRLGLGTmtfggpwgGVDEA-------EAIAIldaALDAGINFFDTADVYgpgRSEELLGEAL------KGRPR 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  77 EDIFYTSKL--------WSTSHRPELVRPSLENSLRKLNLDYVDLYLIHFPvslkpgnellpkDehgnlifDTVDLCDTW 148
Cdd:COG0667  75 DDVVIATKVgrrmgpgpNGRGLSREHIRRAVEASLRRLGTDYIDLYQLHRP------------D-------PDTPIEETL 135

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 149 EAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHLyLNQS---KLLAYCKMNDIVLVAYGALG----T 221
Cdd:COG0667 136 GALDELVREGKIRYIGVSNYSAEQLRRALAIAEGLPPIVAVQNEYSL-LDRSaeeELLPAARELGVGVLAYSPLAggllT 214

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 222 QRYK--------------YCINEDTPVLLD-DPVLCAMAKKYKRTPALIALRYQLDRGIVAL----AKSfnEERIRENMQ 282
Cdd:COG0667 215 GKYRrgatfpegdraatnFVQGYLTERNLAlVDALRAIAAEHGVTPAQLALAWLLAQPGVTSvipgARS--PEQLEENLA 292

                       330
                ....*....|....*
gi 19527284 283 VFDFQLASDDMKILD 297
Cdd:COG0667 293 AADLELSAEDLAALD 307

AKR_AKR11B3

cd19085

Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is ...

16-303

6.93e-35

Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is a founding member of aldo-keto reductase family 11 member B3(AKR11B3). It is responsible for methylglyoxal detoxification.

Pssm-ID: 381311 [Multi-domain] Cd Length: 292 Bit Score: 128.47 E-value: 6.93e-35

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  16 IPVLGFGT------YATEEHLKKKSMESTKIAIDVGFCHIDCSHLYQN---EEEIGQAILSKiedgtvkREDIFYTSKLW 86
Cdd:cd19085   1 VSRLGLGCwqfgggYWWGDQDDEESIATIHAALDAGINFFDTAEAYGDghsEEVLGKALKGR-------RDDVVIATKVS 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  87 STSHRPELVRPSLENSLRKLNLDYVDLYLIHFPVSlkpgnellpkdehgnlifdTVDLCDTWEAMEKCKDAGLAKSIGVS 166
Cdd:cd19085  74 PDNLTPEDVRKSCERSLKRLGTDYIDLYQIHWPSS-------------------DVPLEETMEALEKLKEEGKIRAIGVS 134

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 167 NFNRRQLEMILnKPGlkyKPVCNQVECHLyLNQSK---LLAYCKMNDIVLVAYGAL------GtqryKYCINEDTP---- 233
Cdd:cd19085 135 NFGPAQLEEAL-DAG---RIDSNQLPYNL-LWRAIeyeILPFCREHGIGVLAYSPLaqglltG----KFSSAEDFPpgda 205

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 234 ----VLLDDP-----------VLCAMAKKYKRTPALIALRYQLDRGIV--ALAKSFNEERIRENMQVFDFQLASDDMKIL 296
Cdd:cd19085 206 rtrlFRHFEPgaeeetfealeKLKEIADELGVTMAQLALAWVLQQPGVtsVIVGARNPEQLEENAAAVDLELSPSVLERL 285


                ....*..
gi 19527284 297 DGLDRNL 303
Cdd:cd19085 286 DEISDPL 292

AKR_SF

cd06660

Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ...

17-282

1.04e-28

Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.

Pssm-ID: 381296 [Multi-domain] Cd Length: 232 Bit Score: 110.30 E-value: 1.04e-28

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  17 PVLGFGTYA-TEEHLKKKSMESTKIAIDVGFCHIDCSHLY---QNEEEIGQAIlskieDGTVKREDIFYTSK-----LWS 87
Cdd:cd06660   1 SRLGLGTMTfGGDGDEEEAFALLDAALEAGGNFFDTADVYgdgRSERLLGRWL-----KGRGNRDDVVIATKgghppGGD 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  88 TSHR---PELVRPSLENSLRKLNLDYVDLYLIHFPvslkpgNELLPKDEhgnlifdtvdlcdTWEAMEKCKDAGLAKSIG 164
Cdd:cd06660  76 PSRSrlsPEHIRRDLEESLRRLGTDYIDLYYLHRD------DPSTPVEE-------------TLEALNELVREGKIRYIG 136

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 165 VSNFNRRQLEMILN--KPGLKYKPVCNQVECHLYLNQ---SKLLAYCKMNDIVLVAYGALGtqrykycinedtpvllddp 239
Cdd:cd06660 137 VSNWSAERLAEALAyaKAHGLPGFAAVQPQYSLLDRSpmeEELLDWAEENGLPLLAYSPLA------------------- 197

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 19527284 240 vlcamakkykRTPALIALRYQLDR--GIVALAKSFNEERIRENMQ 282
Cdd:cd06660 198 ----------RGPAQLALAWLLSQpfVTVPIVGARSPEQLEENLA 232

YdhF

COG4989

Predicted oxidoreductase YdhF [General function prediction only];

41-288

1.98e-26

Predicted oxidoreductase YdhF [General function prediction only];

Pssm-ID: 444013 [Multi-domain] Cd Length: 299 Bit Score: 106.00 E-value: 1.98e-26

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  41 AIDVG---FCHIDCSHLYQNEEEIGQAI-LSKIedgtvKREDIFYTSKL-----------------WSTSHrpelVRPSL 99
Cdd:COG4989  40 ALELGittFDHADIYGGYTCEALFGEALkLSPS-----LREKIELQTKCgirlpseardnrvkhydTSKEH----IIASV 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 100 ENSLRKLNLDYVDLYLIHFPvslkpgnellpkdehgnlifDT-VDLCDTWEAMEKCKDAGLAKSIGVSNFNRRQLEMiLN 178
Cdd:COG4989 111 EGSLRRLGTDYLDLLLLHRP--------------------DPlMDPEEVAEAFDELKASGKVRHFGVSNFTPSQFEL-LQ 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 179 KpGLKYKPVCNQVECHLyLNQSKL----LAYCKMNDIVLVAYGALGTQRYKYCINEDTPVLLDdpVLCAMAKKYKRTPAL 254
Cdd:COG4989 170 S-ALDQPLVTNQIELSL-LHTDAFddgtLDYCQLNGITPMAWSPLAGGRLFGGFDEQFPRLRA--ALDELAEKYGVSPEA 245

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 19527284 255 IALRYQLdR---GIVALAKSFNEERIRENMQVFDFQL 288
Cdd:COG4989 246 IALAWLL-RhpaGIQPVIGTTNPERIKAAAAALDIEL 281

AKR_BsYcsN_EcYdhF-like

cd19092

Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and ...

41-288

3.70e-25

Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and Escherichia coli YdhF are prototypes of this family. They are uncharacterized aldo/keto reductase family oxidoreductases.

Pssm-ID: 381318 [Multi-domain] Cd Length: 287 Bit Score: 102.25 E-value: 3.70e-25

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  41 AIDVGFCHIDCSHLYQN---EEEIGQAILSKiedgTVKREDIFYTSK----------LWSTSH---RPELVRPSLENSLR 104
Cdd:cd19092  33 ALELGITTFDHADIYGGgkcEELFGEALALN----PGLREKIEIQTKcgirlgddprPGRIKHydtSKEHILASVEGSLK 108

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 105 KLNLDYVDLYLIHFPvslkpgnellpkdehgnlifDTvdLCDTWE---AMEKCKDAGLAKSIGVSNFNRRQLEMiLNKpG 181
Cdd:cd19092 109 RLGTDYLDLLLLHRP--------------------DP--LMDPEEvaeAFDELVKSGKVRYFGVSNFTPSQIEL-LQS-Y 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 182 LKYKPVCNQVEC---HLYLNQSKLLAYCKMNDIVLVAYGALGTQRYKYCINEDTPVLLDdpVLCAMAKKYKRTPALIALR 258
Cdd:cd19092 165 LDQPLVTNQIELsllHTEAIDDGTLDYCQLLDITPMAWSPLGGGRLFGGFDERFQRLRA--ALEELAEEYGVTIEAIALA 242

                       250       260       270
                ....*....|....*....|....*....|..
gi 19527284 259 --YQLDRGIVALAKSFNEERIRENMQVFDFQL 288
Cdd:cd19092 243 wlLRHPARIQPILGTTNPERIRSAVKALDIEL 274

AKR_AKR11A1_11D1

cd19083

AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto ...

19-299

3.50e-24

AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto reductase IolS, also called vegetative protein 147 (VEG147), is a founding member of aldo-keto reductase family 11 member A1 (AKR11A1). It is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose, and methylglyoxal in the presence of NADPH, albeit with poor efficiency in vitro. Bacillus aryabhattai aldo keto reductase is a founding member of aldo-keto reductase family 11 member D1 (AKR11D1).

Pssm-ID: 381309 [Multi-domain] Cd Length: 307 Bit Score: 100.19 E-value: 3.50e-24

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  19 LGFGTYATEEH-----LKKKS-MESTKIAIDVGFCHIDCSHLY---QNEEEIGQAILSKiedgtvKREDIFYTSK---LW 86
Cdd:cd19083  14 IGLGTNAVGGHnlypnLDEEEgKDLVREALDNGVNLLDTAFIYglgRSEELVGEVLKEY------NRNEVVIATKgahKF 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  87 ST-----SHRPELVRPSLENSLRKLNLDYVDLYLIHFPvslkpgNELLPKDEHGNlifdtvdlcdtweAMEKCKDAGLAK 161
Cdd:cd19083  88 GGdgsvlNNSPEFLRSAVEKSLKRLNTDYIDLYYIHFP------DGETPKAEAVG-------------ALQELKDEGKIR 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 162 SIGVSNFNRRQLEMiLNKPGLkykpvCNQVE-CHLYLNQ---SKLLAYCKMNDIVLVAYGAL--GTQRYKYciNEDTpVL 235
Cdd:cd19083 149 AIGVSNFSLEQLKE-ANKDGY-----VDVLQgEYNLLQReaeEDILPYCVENNISFIPYFPLasGLLAGKY--TKDT-KF 219

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 236 LDDPV---------------------LCAMAKKYKRTPALIALRYQLDR----GIVALAKsfNEERIRENMQVFDFQLAS 290
Cdd:cd19083 220 PDNDLrndkplfkgerfsenldkvdkLKSIADEKGVTVAHLALAWYLTRpaidVVIPGAK--RAEQVIDNLKALDVTLTE 297


                ....*....
gi 19527284 291 DDMKILDGL 299
Cdd:cd19083 298 EEIAFIDAL 306

AKR_unchar

cd19102

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...

16-299

3.30e-22

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.

Pssm-ID: 381328 [Multi-domain] Cd Length: 302 Bit Score: 94.28 E-value: 3.30e-22

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  16 IPVLGFGTYAT----EEHL-----KKKSMESTKIAIDVGFCHIDCSHLY---QNEEEIGQAILSKiedgtvkREDIFYTS 83
Cdd:cd19102   1 LTTIGLGTWAIggggWGGGwgpqdDRDSIAAIRAALDLGINWIDTAAVYglgHSEEVVGRALKGL-------RDRPIVAT 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  84 K---LW------STSHRPELVRPSLENSLRKLNLDYVDLYLIHFPVSlkpgnellpkdehgnlifdTVDLCDTWEAMEKC 154
Cdd:cd19102  74 KcglLWdeegriRRSLKPASIRAECEASLRRLGVDVIDLYQIHWPDP-------------------DEPIEEAWGALAEL 134

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 155 KDAGLAKSIGVSNFNRRQLEMIL-------NKPGlkYKPVCNQVEchlylnqSKLLAYCKMNDIVLVAY---------GA 218
Cdd:cd19102 135 KEEGKVRAIGVSNFSVDQMKRCQaihpiasLQPP--YSLLRRGIE-------AEILPFCAEHGIGVIVYspmqsglltGK 205

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 219 LGTQRYKYCINEDTPV---------------LLDdpVLCAMAKKYKRTPALIALRYQLDRGIV--ALAKSFNEERIRENM 281
Cdd:cd19102 206 MTPERVASLPADDWRRrspffqepnlarnlaLVD--ALRPIAERHGRTVAQLAIAWVLRRPEVtsAIVGARRPDQIDETV 283

                       330
                ....*....|....*...
gi 19527284 282 QVFDFQLASDDMKILDGL 299
Cdd:cd19102 284 GAADLRLTPEELAEIEAL 301

AKR_unchar

cd19100

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...

13-166

4.50e-22

Pssm-ID: 381326 [Multi-domain] Cd Length: 238 Bit Score: 92.55 E-value: 4.50e-22

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  13 GHSIPVLGFGTyateEHLKKKSM-ESTKI---AIDVGFCHIDCSHLYQN-EEEIGQAILSKiedgtvkREDIFYTSKLWS 87
Cdd:cd19100   8 GLKVSRLGFGG----GPLGRLSQeEAAAIirrALDLGINYFDTAPSYGDsEEKIGKALKGR-------RDKVFLATKTGA 76

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19527284  88 TShrPELVRPSLENSLRKLNLDYVDLYLIHFPVSLKPGNELLPKDEhgnlifdtvdlcdTWEAMEKCKDAGLAKSIGVS 166
Cdd:cd19100  77 RD--YEGAKRDLERSLKRLGTDYIDLYQLHAVDTEEDLDQVFGPGG-------------ALEALLEAKEEGKIRFIGIS 140

AKR_AKR11B1

cd19148

Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also ...

20-297

1.49e-21

Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.

Pssm-ID: 381374 [Multi-domain] Cd Length: 302 Bit Score: 92.76 E-value: 1.49e-21

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  20 GFGTYA--------TEEhlkKKSMESTKIAIDVGFCHIDCSHLY---QNEEEIGQAIlskieDGTVKREDIFYTSKL--- 85
Cdd:cd19148   8 ALGTWAiggwmwggTDE---KEAIETIHKALDLGINLIDTAPVYgfgLSEEIVGKAL-----KEYGKRDRVVIATKVgle 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  86 WSTSH------RPELVRPSLENSLRKLNLDYVDLYLIHFPvslkpgNELLPKDEhgnlifdtvdlcdTWEAMEKCKDAGL 159
Cdd:cd19148  80 WDEGGevvrnsSPARIRKEVEDSLRRLQTDYIDLYQVHWP------DPLVPIEE-------------TAEALKELLDEGK 140

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 160 AKSIGVSNFNRRQLEmilnkpglKYKPVCNQVECHLYLN------QSKLLAYCKMNDIVLVAYGALgtqrykyC------ 227
Cdd:cd19148 141 IRAIGVSNFSPEQME--------TFRKVAPLHTVQPPYNlfereiEKDVLPYARKHNIVTLAYGAL-------Crgllsg 205

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 228 -INEDTPVLLDD-----P---------VLCAMAK-------KYKRTPALIALRYQLDRGI--VALAKSFNEERIRENMQV 283
Cdd:cd19148 206 kMTKDTKFEGDDlrrtdPkfqeprfsqYLAAVEEldklaqeRYGKSVIHLAVRWLLDQPGvsIALWGARKPEQLDAVDEV 285

                       330
                ....*....|....
gi 19527284 284 FDFQLASDDMKILD 297
Cdd:cd19148 286 FGWSLNDEDMKEID 299

COG1453

Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];

13-304

8.56e-20

Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];

Pssm-ID: 441062 [Multi-domain] Cd Length: 365 Bit Score: 88.72 E-value: 8.56e-20

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  13 GHSIPVLGFGTyateEHLKKKSMEST----KIAIDVGFCHIDCSHLYQNEEE-IGQAiLSKIedgtvkREDIFYTSKLWS 87
Cdd:COG1453  10 GLEVSVLGFGG----MRLPRKDEEEAealiRRAIDNGINYIDTARGYGDSEEfLGKA-LKGP------RDKVILATKLPP 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  88 TSHRPELVRPSLENSLRKLNLDYVDLYLIHFpvslkpgnelLPKDEHGNLIFDTVDLcdtWEAMEKCKDAGLAKSIGVSN 167
Cdd:COG1453  79 WVRDPEDMRKDLEESLKRLQTDYIDLYLIHG----------LNTEEDLEKVLKPGGA---LEALEKAKAEGKIRHIGFST 145

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 168 FNRRQ-LEMILNKPGLKYkpvCNqveCHL-YLNQS-----KLLAYCKMNDIVLVAYGALGTQRykycinedtpvLLDDPV 240
Cdd:COG1453 146 HGSLEvIKEAIDTGDFDF---VQ---LQYnYLDQDnqageEALEAAAEKGIGVIIMKPLKGGR-----------LANPPE 208

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19527284 241 LCAMAKKYKRTPALIALRYQLDRGIVALAKS--FNEERIRENMQVFD--FQLASDDMKILDGLDRNLR 304
Cdd:COG1453 209 KLVELLCPPLSPAEWALRFLLSHPEVTTVLSgmSTPEQLDENLKTADnlEPLTEEELAILERLAEELG 276

AKR_AKR13B1

cd19088

AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde ...

16-288

9.27e-20

AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.

Pssm-ID: 381314 [Multi-domain] Cd Length: 256 Bit Score: 86.89 E-value: 9.27e-20

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  16 IPVLGFGT-------YATEEHLKKKSMESTKIAIDVGFCHIDCSHLY---QNEEEIGQA---------ILSKIedGTVKR 76
Cdd:cd19088   1 VSRLGYGAmrltgpgIWGPPADREEAIAVLRRALELGVNFIDTADSYgpdVNERLIAEAlhpypddvvIATKG--GLVRT 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  77 EDifytsKLWSTSHRPELVRPSLENSLRKLNLDYVDLYLIHfpvslkpgnellpkdehgnLIFDTVDLCDTWEAMEKCKD 156
Cdd:cd19088  79 GP-----GWWGPDGSPEYLRQAVEASLRRLGLDRIDLYQLH-------------------RIDPKVPFEEQLGALAELQD 134

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 157 AGLAKSIGVSNFNRRQLEMILNKPGLkykpVCNQVECHLYLNQS-KLLAYCKMNDIVLVAYGALGTQrykycinedtPVL 235
Cdd:cd19088 135 EGLIRHIGLSNVTVAQIEEARAIVRI----VSVQNRYNLANRDDeGVLDYCEAAGIAFIPWFPLGGG----------DLA 200

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 19527284 236 LDDPVLCAMAKKYKRTPALIALRYQLDRG--IVALAKSFNEERIRENMQVFDFQL 288
Cdd:cd19088 201 QPGGLLAEVAARLGATPAQVALAWLLARSpvMLPIPGTSSVEHLEENLAAAGLRL 255

AKR_PA4992-like

cd19095

Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the ...

17-169

1.97e-17

Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the prototype of this family. It is a putative aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.

Pssm-ID: 381321 [Multi-domain] Cd Length: 253 Bit Score: 80.36 E-value: 1.97e-17

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  17 PVLGFGT--------YATEEHLKKKSMEstkiAIDVGFCHIDCSHLYQNEEE-IGQAIlskiedGTVKREDIFYTSKLWS 87
Cdd:cd19095   1 SVLGLGTsgigrvwgVPSEAEAARLLNT----ALDLGINLIDTAPAYGRSEErLGRAL------AGLRRDDLFIATKVGT 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  88 TS--------HRPELVRPSLENSLRKLNLDYVDLYLIHFPVSLKPGNELLpkdehgnlifdtvdlcdtwEAMEKCKDAGL 159
Cdd:cd19095  71 HGeggrdrkdFSPAAIRASIERSLRRLGTDYIDLLQLHGPSDDELTGEVL-------------------ETLEDLKAAGK 131

                       170
                ....*....|
gi 19527284 160 AKSIGVSNFN 169
Cdd:cd19095 132 VRYIGVSGDG 141

AKR_Fe-S_oxidoreductase

cd19096

Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S ...

17-285

2.19e-17

Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S oxidoreductase that belongs to aldo-keto reductase (AKR) superfamily. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.

Pssm-ID: 381322 [Multi-domain] Cd Length: 255 Bit Score: 80.30 E-value: 2.19e-17

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  17 PVLGFGTY-ATEEHLKKKSMESTK--I--AIDVGFCHIDCSHLY---QNEEEIGQAiLSKiedgtVKREDIFYTSKL-WS 87
Cdd:cd19096   1 SVLGFGTMrLPESDDDSIDEEKAIemIryAIDAGINYFDTAYGYgggKSEEILGEA-LKE-----GPREKFYLATKLpPW 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  88 TSHRPELVRPSLENSLRKLNLDYVDLYLIHFPVSLkpgnELLPKDEHGNLifdtvdlcdtWEAMEKCKDAGLAKSIGVSn 167
Cdd:cd19096  75 SVKSAEDFRRILEESLKRLGVDYIDFYLLHGLNSP----EWLEKARKGGL----------LEFLEKAKKEGLIRHIGFS- 139

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 168 F--NRRQLEMILNkpglkykpvCNQVEC---HL-YLNQ-----SKLLAYCKMNDIVLVAYGALGTQRykycinedtpvLL 236
Cdd:cd19096 140 FhdSPELLKEILD---------SYDFDFvqlQYnYLDQenqagRPGIEYAAKKGMGVIIMEPLKGGG-----------LA 199

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 19527284 237 DDP-VLCAMAKKYKRTPALIALRYQLDRGIVALAKS--FNEERIRENMQVFD 285
Cdd:cd19096 200 NNPpEALAILCGAPLSPAEWALRFLLSHPEVTTVLSgmSTPEQLDENIAAAD 251

AKR_unchar

cd19101

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...

31-297

4.04e-17

Pssm-ID: 381327 [Multi-domain] Cd Length: 304 Bit Score: 80.33 E-value: 4.04e-17

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  31 KKKSMESTKIAIDVGFCHIDCSHLYQNEEEI-GQAILSKIEDGTVKREDIFYT------SKLWSTshrPELVRPSLENSL 103
Cdd:cd19101  22 EDAAVRAMAAYVDAGLTTFDCADIYGPAEELiGEFRKRLRRERDAADDVQIHTkwvpdpGELTMT---RAYVEAAIDRSL 98

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 104 RKLNLDYVDLYLIHFpvslkpgnellpKDehgnliFDTVDLCDTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPglk 183
Cdd:cd19101  99 KRLGVDRLDLVQFHW------------WD------YSDPGYLDAAKHLAELQEEGKIRHLGLTNFDTERLREILDAG--- 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 184 YKPVCNQVECHLyLNQ---SKLLAYCKMNDIVLVAYGALG----TQRYkYCINEDTPVLLDDP----------------- 239
Cdd:cd19101 158 VPIVSNQVQYSL-LDRrpeNGMAALCEDHGIKLLAYGTLAggllSEKY-LGVPEPTGPALETRslqkyklmidewggwdl 235

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19527284 240 ------VLCAMAKKYKRTPALIALRYQLDR----GIVALAKsfNEERIRENMQVFDFQLASDDMKILD 297
Cdd:cd19101 236 fqellrTLKAIADKHGVSIANVAVRWVLDQpgvaGVIVGAR--NSEHIDDNVRAFSFRLDDEDRAAID 301

AKR_unchar

cd19105

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...

13-166

8.43e-17

Pssm-ID: 381331 [Multi-domain] Cd Length: 250 Bit Score: 78.40 E-value: 8.43e-17

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  13 GHSIPVLGFGTYATeehlkkkSMESTKI---AIDVGFCHIDCSHLYQN---EEEIGQAIlskiedGTVKREDIFYTSK-- 84
Cdd:cd19105  10 GLKVSRLGFGGGGL-------PRESPELlrrALDLGINYFDTAEGYGNgnsEEIIGEAL------KGLRRDKVFLATKas 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  85 LWSTSHRPELVRPSLENSLRKLNLDYVDLYLIHfpvslkpgnELLPKDEHGnlifdtvdLCDTW-EAMEKCKDAGLAKSI 163
Cdd:cd19105  77 PRLDKKDKAELLKSVEESLKRLQTDYIDIYQLH---------GVDTPEERL--------LNEELlEALEKLKKEGKVRFI 139


                ...
gi 19527284 164 GVS 166
Cdd:cd19105 140 GFS 142

AKR_AKR11B2

cd19149

Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; ...

11-292

5.66e-16

Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.

Pssm-ID: 381375 [Multi-domain] Cd Length: 315 Bit Score: 76.93 E-value: 5.66e-16

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  11 NDGHSIPVLGFGTYA---------TEEhlkKKSMESTKIAIDVGFCHIDCSHLYQN---EEEIGQAILSKiedgtvkRED 78
Cdd:cd19149   6 KSGIEASVIGLGTWAigggpwwggSDD---NESIRTIHAALDLGINLIDTAPAYGFghsEEIVGKAIKGR-------RDK 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  79 IFYTSK---LWS---TSH-------------RPELVRPSLENSLRKLNLDYVDLYLIHFPVSLKPgnellpkdehgnlif 139
Cdd:cd19149  76 VVLATKcglRWDregGSFffvrdgvtvyknlSPESIREEVEQSLKRLGTDYIDLYQTHWQDVETP--------------- 140

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 140 dtvdLCDTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNkpglkykpvCNQVEchlyLNQSK-----------LLAYCKM 208
Cdd:cd19149 141 ----IEETMEALEELKRQGKIRAIGASNVSVEQIKEYVK---------AGQLD----IIQEKysmldrgiekeLLPYCKK 203

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 209 NDIVLVAYGAL-----------------GTQRYKYCI----NEDTPVLLDDPVLcAMAKKYKRTPALIALRYQLDRG--I 265
Cdd:cd19149 204 NNIAFQAYSPLeqglltgkitpdrefdaGDARSGIPWfspeNREKVLALLEKWK-PLCEKYGCTLAQLVIAWTLAQPgiT 282

                       330       340
                ....*....|....*....|....*..
gi 19527284 266 VALAKSFNEERIRENMQVFDFQLASDD 292
Cdd:cd19149 283 SALCGARKPEQAEENAKAGDIRLSAED 309

Aldo_ket_red_shaker-like

cd19074

Shaker potassium channel beta subunit family and similar proteins; This family includes ...

13-291

1.39e-15

Shaker potassium channel beta subunit family and similar proteins; This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. The family also includes Drosophila melanogaster Hk protein, a founding member of aldo-keto reductase family 6 member B1 (AKR6B1), as well as voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa, founding members of AKR6C1and AKR6C2, respectively. Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.

Pssm-ID: 381300 [Multi-domain] Cd Length: 297 Bit Score: 75.71 E-value: 1.39e-15

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  13 GHSIPVLGFGTYATeeHLKKKSMESTKI----AIDVGFCHIDCSHLY---QNEEEIGQAIlskiedGTVKREDIFYTSKL 85
Cdd:cd19074   1 GLKVSELSLGTWLT--FGGQVDDEDAKAcvrkAYDLGINFFDTADVYaagQAEEVLGKAL------KGWPRESYVISTKV 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  86 -WSTSHRPE---LVRP----SLENSLRKLNLDYVDLYLIHFPvslkpgnellpkDEhgnlifdTVDLCDTWEAMEKCKDA 157
Cdd:cd19074  73 fWPTGPGPNdrgLSRKhifeSIHASLKRLQLDYVDIYYCHRY------------DP-------ETPLEETVRAMDDLIRQ 133

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 158 GLAKSIGVSNFNRRQLE--MILNKPGLKYKPVCNQVECHLyLNQSK---LLAYCKMNDIVLVAYGALG----TQRYKYCI 228
Cdd:cd19074 134 GKILYWGTSEWSAEQIAeaHDLARQFGLIPPVVEQPQYNM-LWREIeeeVIPLCEKNGIGLVVWSPLAqgllTGKYRDGI 212

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 229 NED--------------TPVLLDDPV-----LCAMAKKYKRTPALIALRYQLDRGIV--ALAKSFNEERIRENMQVFDFQ 287
Cdd:cd19074 213 PPPsrsratdednrdkkRRLLTDENLekvkkLKPIADELGLTLAQLALAWCLRNPAVssAIIGASRPEQLEENVKASGVK 292


                ....
gi 19527284 288 LASD 291
Cdd:cd19074 293 LSPE 296

AKR_unchar

cd19103

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...

73-299

2.95e-15

Pssm-ID: 381329 [Multi-domain] Cd Length: 299 Bit Score: 74.68 E-value: 2.95e-15

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  73 TVKREDIFYTSKLWST--SHRPELVRPSLENSLRKLNLDYVDLYLIHfpvslkpgnelLPKDEHGNlifdTVDLCDTWEA 150
Cdd:cd19103  70 RYPREDYIISTKFTPQiaGQSADPVADMLEGSLARLGTDYIDIYWIH-----------NPADVERW----TPELIPLLKS 134

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 151 mekckdaGLAKSIGVSNFNRRQLEM---ILNKPGLKYKPVCNqvecH---LYLN--QSKLLAYCKMNDIVLVAY-----G 217
Cdd:cd19103 135 -------GKVKHVGVSNHNLAEIKRaneILAKAGVSLSAVQN----HyslLYRSseEAGILDYCKENGITFFAYmvleqG 203

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 218 AL------------GTQRYK-YciNEDTPVLLD-DPVLCAMAKKYKRTPALIALRYQLDRGIVALAKSFNEERIRENMQV 283
Cdd:cd19103 204 ALsgkydtkhplpeGSGRAEtY--NPLLPQLEElTAVMAEIGAKHGASIAQVAIAWAIAKGTTPIIGVTKPHHVEDAARA 281

                       250
                ....*....|....*.
gi 19527284 284 FDFQLASDDMKILDGL 299
Cdd:cd19103 282 ASITLTDDEIKELEQL 297

AKR_AKR11C1

cd19086

AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase ...

15-166

4.39e-15

AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase YqkF is a founding member of aldo-keto reductase family 11 member C1 (AKR11C1). It may function as oxidoreductase. This family also includes Bacillus halodurans AKR11C1, an NADPH-dependent 4-hydroxy-2,3-trans-nonenal reductase.

Pssm-ID: 381312 [Multi-domain] Cd Length: 238 Bit Score: 73.28 E-value: 4.39e-15

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  15 SIPVLGFGTYA-----TEEHLKKKSMESTKIAIDVG--FchIDCSHLYQN---EEEIGQAILSKiedgtvkREDIFYTSK 84
Cdd:cd19086   2 EVSEIGFGTWGlggdwWGDVDDAEAIRALRAALDLGinF--FDTADVYGDghsERLLGKALKGR-------RDKVVIATK 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  85 L---------WSTSHRPELVRPSLENSLRKLNLDYVDLYLIHfpvslKPGNELLPKDEHgnlifdtvdlcdtWEAMEKCK 155
Cdd:cd19086  73 FgnrfdggpeRPQDFSPEYIREAVEASLKRLGTDYIDLYQLH-----NPPDEVLDNDEL-------------FEALEKLK 134

                       170
                ....*....|.
gi 19527284 156 DAGLAKSIGVS 166
Cdd:cd19086 135 QEGKIRAYGVS 145

AKR_AKR13A1

cd19144

AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC ...

11-294

4.99e-15

AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor.

Pssm-ID: 381370 [Multi-domain] Cd Length: 323 Bit Score: 74.40 E-value: 4.99e-15

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  11 NDGHSIPVLGFGTYATEEHLKKKSMESTKI-----AIDVGFCHIDCSHLYQ-NEEEIGQAILSKiedgTVKREDIFYTSK 84
Cdd:cd19144   8 RNGPSVPALGFGAMGLSAFYGPPKPDEERFavldaAFELGCTFWDTADIYGdSEELIGRWFKQN----PGKREKIFLATK 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  85 L----------WSTSHRPELVRPSLENSLRKLNLDYVDLYLIHfpvslkpgnELLPKdehgnlifdtVDLCDTWEAMEKC 154
Cdd:cd19144  84 FgieknvetgeYSVDGSPEYVKKACETSLKRLGVDYIDLYYQH---------RVDGK----------TPIEKTVAAMAEL 144

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 155 KDAGLAKSIGVSNFN----RR----------QLEmilnkpglkYKPVCNQVEchlyLNQSKLLAYCKMNDIVLVAYGALG 220
Cdd:cd19144 145 VQEGKIKHIGLSECSaetlRRahavhpiaavQIE---------YSPFSLDIE----RPEIGVLDTCRELGVAIVAYSPLG 211

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 221 ----TQRYKYciNEDTP--------------------VLLDDpvLCAMAKKYKRTPALIALRYQLDRG--IVALAKSFNE 274
Cdd:cd19144 212 rgflTGAIRS--PDDFEegdfrrmaprfqaenfpknlELVDK--IKAIAKKKNVTAGQLTLAWLLAQGddIIPIPGTTKL 287

                       330       340
                ....*....|....*....|
gi 19527284 275 ERIRENMQVFDFQLASDDMK 294
Cdd:cd19144 288 KRLEENLGALKVKLTEEEEK 307

AKR_AKR15A-like

cd19090

AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes ...

17-166

7.43e-15

AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH) and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. The family also includes L-galactose dehydrogenase (L-galDH) and D-arabinose 1-dehydrogenase (ARA2). L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).

Pssm-ID: 381316 [Multi-domain] Cd Length: 278 Bit Score: 73.36 E-value: 7.43e-15

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  17 PVLGFGTYA--------TEEHlkkkSMESTKIAIDVGFCHIDCSHLYQNEEE-IGQAIlskiedGTVKREDIFYTSKL-- 85
Cdd:cd19090   1 SALGLGTAGlggvfggvDDDE----AVATIRAALDLGINYIDTAPAYGDSEErLGLAL------AELPREPLVLSTKVgr 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  86 -----WSTShrPELVRPSLENSLRKLNLDYVDLYLIHFPVSLKPGNELLPKdehGNLifdtvdlcdtwEAMEKCKDAGLA 160
Cdd:cd19090  71 lpedtADYS--ADRVRRSVEESLERLGRDRIDLLMIHDPERVPWVDILAPG---GAL-----------EALLELKEEGLI 134


                ....*.
gi 19527284 161 KSIGVS 166
Cdd:cd19090 135 KHIGLG 140

AKR_AKR9C1

cd19081

AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a ...

58-297

1.45e-14

AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a founding member of aldo-keto reductase family 9 member C1 (AKR9C1).

Pssm-ID: 381307 [Multi-domain] Cd Length: 308 Bit Score: 73.02 E-value: 1.45e-14

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  58 EEEIGQAILSKiedgtVKREDIFYTSKL--WSTSHRPEL----VRPSLENSLRKLNLDYVDLYLIHFPvslkpgnellpk 131
Cdd:cd19081  62 ETIIGRWLKSR-----GKRDRVVIATKVgfPMGPNGPGLsrkhIRRAVEASLRRLQTDYIDLYQAHWD------------ 124

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 132 DehgnlifDTVDLCDTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILN---KPGLKyKPVCNQVECHLYLNQS---KLLAY 205
Cdd:cd19081 125 D-------PATPLEETLGALNDLIRQGKVRYIGASNYSAWRLQEALElsrQHGLP-RYVSLQPEYNLVDRESfegELLPL 196

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 206 CKMNDIVLVAYGALGT--------------------QRYKYCINEDTPVLLDdpVLCAMAKKYKRTPALIALRYQLDRGI 265
Cdd:cd19081 197 CREEGIGVIPYSPLAGgfltgkyrseadlpgstrrgEAAKRYLNERGLRILD--ALDEVAAEHGATPAQVALAWLLARPG 274

                       250       260       270
                ....*....|....*....|....*....|....
gi 19527284 266 VA--LAKSFNEERIRENMQVFDFQLASDDMKILD 297
Cdd:cd19081 275 VTapIAGARTVEQLEDLLAAAGLRLTDEEVARLD 308

AKR_unchar

cd19099

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...

19-166

1.84e-13

Pssm-ID: 381325 [Multi-domain] Cd Length: 316 Bit Score: 69.65 E-value: 1.84e-13

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  19 LGFGTY--ATEEHLKKKSMESTKIAIDVGFCHIDCSHLYQN---EEEIGQAILSKIEDGTVKREDIFYTSK--------- 84
Cdd:cd19099   6 LGLGTYrgDSDDETDEEYREALKAALDSGINVIDTAINYRGgrsERLIGKALRELIEKGGIKRDEVVIVTKagyipgdgd 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  85 -------------------------LWSTSHrPELVRPSLENSLRKLNLDYVDLYLIHFPVslkpgnELLPKDEHGNLiF 139
Cdd:cd19099  86 eplrplkyleeklgrglidvadsagLRHCIS-PAYLEDQIERSLKRLGLDTIDLYLLHNPE------EQLLELGEEEF-Y 157

                       170       180
                ....*....|....*....|....*..
gi 19527284 140 DTVDlcDTWEAMEKCKDAGLAKSIGVS 166
Cdd:cd19099 158 DRLE--EAFEALEEAVAEGKIRYYGIS 182

AKR_Tas-like

cd19094

Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the ...

21-301

2.59e-13

Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the prototype of this family. It is an NADP(H)-dependent aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NADP(H) as a hydride donor.

Pssm-ID: 381320 [Multi-domain] Cd Length: 328 Bit Score: 69.52 E-value: 2.59e-13

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  21 FGTYATEEhlkkksmESTKI---AIDVGFCHIDCSHLY----------QNEEEIGQAILSKiedgtVKREDIF------- 80
Cdd:cd19094  11 WGEQNTEA-------EAHEQldyAFDEGVNFIDTAEMYpvppspetqgRTEEIIGSWLKKK-----GNRDKVVlatkvag 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  81 YTSKLW-----STSHRPELVRPSLENSLRKLNLDYVDLYLIHFP---VSLKPGNELLPKDEHGnlifDTVDLCDTWEAME 152
Cdd:cd19094  79 PGEGITwprggGTRLDRENIREAVEGSLKRLGTDYIDLYQLHWPdryTPLFGGGYYTEPSEEE----DSVSFEEQLEALG 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 153 KCKDAGLAKSIGVSN--------FNR--RQLemilnkpGLKyKPVCNQVECHLyLNQSKL--LA-YCKMNDIVLVAYGAL 219
Cdd:cd19094 155 ELVKAGKIRHIGLSNetpwgvmkFLElaEQL-------GLP-RIVSIQNPYSL-LNRNFEegLAeACHRENVGLLAYSPL 225

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 220 --GTQRYKYCINEDTPV---LLDDP----------------VLCAMAKKYKRTPALIALRYQLDRGIVAL----AKSFne 274
Cdd:cd19094 226 agGVLTGKYLDGAARPEggrLNLFPgymaryrspqaleavaEYVKLARKHGLSPAQLALAWVRSRPFVTStiigATTL-- 303

                       330       340
                ....*....|....*....|....*..
gi 19527284 275 ERIRENMQVFDFQLaSDDmkILDGLDR 301
Cdd:cd19094 304 EQLKENIDAFDVPL-SDE--LLAEIDA 327

AKR_AKR13A_13D

cd19076

AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto ...

6-294

1.47e-12

AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor. Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.

Pssm-ID: 381302 [Multi-domain] Cd Length: 303 Bit Score: 66.86 E-value: 1.47e-12

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284   6 QKIEL-NDGHSIPVLGFGT------YATEEhlKKKSMESTKIAIDVGFCHIDCSHLYQ---NEEEIGQAILSKiedgtvk 75
Cdd:cd19076   1 PTRKLgTQGLEVSALGLGCmgmsafYGPAD--EEESIATLHRALELGVTFLDTADMYGpgtNEELLGKALKDR------- 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  76 REDIFYTSK---LWS-------TSHRPELVRPSLENSLRKLNLDYVDLYLIHFPvslkpgnellpkDehgnlifDTVDLC 145
Cdd:cd19076  72 RDEVVIATKfgiVRDpgsgfrgVDGRPEYVRAACEASLKRLGTDVIDLYYQHRV------------D-------PNVPIE 132

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 146 DTWEAMEKCKDAGLAKSIGVSNFN----RR----------QLEmilnkpglkYKPVCNQVECHlylnqskLLAYCKMNDI 211
Cdd:cd19076 133 ETVGAMAELVEEGKVRYIGLSEASadtiRRahavhpitavQSE---------YSLWTRDIEDE-------VLPTCRELGI 196

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 212 VLVAYGALG----TQRYK---------------------YCINEDtpvLLDdpVLCAMAKKYKRTPALIALRYQLDRG-- 264
Cdd:cd19076 197 GFVAYSPLGrgflTGAIKspedlpeddfrrnnprfqgenFDKNLK---LVE--KLEAIAAEKGCTPAQLALAWVLAQGdd 271

                       330       340       350
                ....*....|....*....|....*....|
gi 19527284 265 IVALAKSFNEERIRENMQVFDFQLASDDMK 294
Cdd:cd19076 272 IVPIPGTKRIKYLEENVGALDVVLTPEELA 301

AKR_PsAKR

cd19091

Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an ...

13-297

1.60e-12

Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an uncharacterized aldo-keto reductase from Polaromonas sp.

Pssm-ID: 381317 [Multi-domain] Cd Length: 319 Bit Score: 66.87 E-value: 1.60e-12

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  13 GHS---IPVLGFG--TYATEEHLKKK--SMEST------KIAIDVGFCHIDCSHLY---QNEEEIGQAIlskiedgTVKR 76
Cdd:cd19091   7 GRSglkVSELALGtmTFGGGGGFFGAwgGVDQEeadrlvDIALDAGINFFDTADVYsegESEEILGKAL-------KGRR 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  77 EDIFYTSKLWST---------SHRPELVRpSLENSLRKLNLDYVDLYLIHFPVSLKPGNELLpkdehgnlifdtvdlcdt 147
Cdd:cd19091  80 DDVLIATKVRGRmgegpndvgLSRHHIIR-AVEASLKRLGTDYIDLYQLHGFDALTPLEETL------------------ 140

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 148 wEAMEKCKDAGLAKSIGVSNFNRRQLEMIL---NKPGLKyKPVCNQVECHLyLNQS---KLLAYCKMNDIVLVAYGALGT 221
Cdd:cd19091 141 -RALDDLVRQGKVRYIGVSNFSAWQIMKALgisERRGLA-RFVALQAYYSL-LGRDlehELMPLALDQGVGLLVWSPLAG 217

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 222 QRY--KYCINEDTP------------VLLDDP-------VLCAMAKKYKRTPALIALRYQLDRGIVAL----AKsfNEER 276
Cdd:cd19091 218 GLLsgKYRRGQPAPegsrlrrtgfdfPPVDRErgydvvdALREIAKETGATPAQVALAWLLSRPTVSSviigAR--NEEQ 295

                       330       340
                ....*....|....*....|.
gi 19527284 277 IRENMQVFDFQLASDDMKILD 297
Cdd:cd19091 296 LEDNLGAAGLSLTPEEIARLD 316

AKR_EcYajO-like

cd19079

Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this ...

36-297

2.76e-11

Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.

Pssm-ID: 381305 [Multi-domain] Cd Length: 312 Bit Score: 63.37 E-value: 2.76e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  36 ESTKI---AIDVGFCHIDCSHLYQN---EEEIGQAIlskieDGTVKREDIFYTSKLW-STSHRP-------ELVRPSLEN 101
Cdd:cd19079  36 ESRPIikrALDLGINFFDTANVYSGgasEEILGRAL-----KEFAPRDEVVIATKVYfPMGDGPngrglsrKHIMAEVDA 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 102 SLRKLNLDYVDLYLIHFPvslkpgnellpkDEHgnlifdtVDLCDTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILN--- 178
Cdd:cd19079 111 SLKRLGTDYIDLYQIHRW------------DYE-------TPIEETLEALHDVVKSGKVRYIGASSMYAWQFAKALHlae 171

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 179 KPGLKyKPVCNQvechLYLN------QSKLLAYCKMNDIVLVAYGALGTQR----------------------YKYCINE 230
Cdd:cd19079 172 KNGWT-KFVSMQ----NHYNllyreeEREMIPLCEEEGIGVIPWSPLARGRlarpwgdtterrrsttdtaklkYDYFTEA 246

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19527284 231 DTPVLLDdpvLCAMAKKYKRTPALIALRYQLDRG-----IVALAKsfnEERIRENMQVFDFQLASDDMKILD 297
Cdd:cd19079 247 DKEIVDR---VEEVAKERGVSMAQVALAWLLSKPgvtapIVGATK---LEHLEDAVAALDIKLSEEEIKYLE 312

AKR_AKR12A1_B1_C1

cd19087

AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, ...

21-168

2.96e-11

AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, Saccharopolyspora erythraea EryBII, and Streptomyces avermitilis aveBVIII are founding members of aldo-keto reductase family 12 member A1 (AKR12A1), B1 (AKR12B1), and C1(AKR12C1), respectively. TylCII acts as a NDP-hexose 2,3-enoyl reductase. EryBII is a mycarose/desosamine reductase involved in L-mycarose and D-desosamine production. aveBVIII functions as a dTDP-4-keto-6-deoxy-L-hexose-2,3-reductase.

Pssm-ID: 381313 [Multi-domain] Cd Length: 310 Bit Score: 63.36 E-value: 2.96e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  21 FGTYATEEhlkkksmESTKI---AIDVGFCHIDCSHLYQN---EEEIGQAILSKiedgtvkREDIFYTSKLW-STSHRPE 93
Cdd:cd19087  23 FGGRTDEE-------TSFAImdrALDAGINFFDTADVYGGgrsEEIIGRWIAGR-------RDDIVLATKVFgPMGDDPN 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  94 L-------VRPSLENSLRKLNLDYVDLYLIHfpvslkpgnellpkdeHgnlIFDTVDLCDTWEAMEKCKDAGLAKSIGVS 166
Cdd:cd19087  89 DrglsrrhIRRAVEASLRRLQTDYIDLYQMH----------------H---FDRDTPLEETLRALDDLVRQGKIRYIGVS 149


                ..
gi 19527284 167 NF 168
Cdd:cd19087 150 NF 151

AKR_AKR7A1-5

cd19075

AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1 ...

43-226

6.06e-11

AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1/AKR7A3/AFAR) from Rattus norvegicus, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR1/AFAR) and aflatoxin B1 aldehyde reductase member 3 (AKR7A3/AFAR2) from Homo sapiens, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR2) from Rattus norvegicus, and aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AKR7A5/AFAR) from Mus musculus, are founding members of aldo-keto reductase family 7 member A1-5 (AKR7A1-5), respectively. AKR7A2 (EC 1.1.1.n11), also called AFB1 aldehyde reductase 1, or AFB1-AR 1, or aldoketoreductase 7, or succinic semialdehyde reductase, or SSA reductase, catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate (GHB). It has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). AKR7A2, AKR7A3 (also called AFB1 aldehyde reductase 2 or AFB1-AR 2), and AKR7A4 (also called AFB1 aldehyde reductase 3, or AFB1-AR 3, or aldoketoreductase 7-like), may be involved in protection of liver against the toxic and carcinogenic effects of aflatoxin B1 (AFB1), a potent hepatocarcinogen. They can reduce the dialdehyde protein-binding form of AFB1 to the non-binding AFB1 dialcohol.

Pssm-ID: 381301 [Multi-domain] Cd Length: 304 Bit Score: 62.19 E-value: 6.06e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  43 DVGFCHIDCSHLYQN---EEEIGQAILSKiEDGTV--KredifyTSKLWSTSHRPELVRPSLENSLRKLNLDYVDLYLIH 117
Cdd:cd19075  31 ERGHTEIDTARVYPDgtsEELLGELGLGE-RGFKIdtK------ANPGVGGGLSPENVRKQLETSLKRLKVDKVDVFYLH 103

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 118 FPvslkpgnellpkDEhgnlifdTVDLCDTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILN--------KP----GLkYK 185
Cdd:cd19075 104 AP------------DR-------STPLEETLAAIDELYKEGKFKEFGLSNYSAWEVAEIVEickengwvLPtvyqGM-YN 163

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 19527284 186 PVCNQVEchlylnqSKLLAYCKMNDIVLVAYGALG----TQRYKY 226
Cdd:cd19075 164 AITRQVE-------TELFPCLRKLGIRFYAYSPLAggflTGKYKY 201

AKR_unchar

cd19097

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...

39-184

8.65e-11

Pssm-ID: 381323 [Multi-domain] Cd Length: 267 Bit Score: 61.39 E-value: 8.65e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  39 KIAIDVGFCHIDCSHLYQNEEE-IGQAILSKiedgtvkrEDIFYTSKL----WSTSHRPELVRPSLENSLRKLNLDYVDL 113
Cdd:cd19097  33 EYALKAGINTLDTAPAYGDSEKvLGKFLKRL--------DKFKIITKLpplkEDKKEDEAAIEASVEASLKRLKVDSLDG 104

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19527284 114 YLIHFPVSLKPGNELLpkdehgnlifdtvdlcdtWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKY 184
Cdd:cd19097 105 LLLHNPDDLLKHGGKL------------------VEALLELKKEGLIRKIGVSVYSPEELEKALESFKIDI 157

AKR_unchar

cd19104

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...

41-261

1.65e-10

Pssm-ID: 381330 [Multi-domain] Cd Length: 321 Bit Score: 61.13 E-value: 1.65e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  41 AIDVGFCHIDCSHLY---QNEEEIGQAIlskieDGtvKREDIFYTSK----LWSTSHRPELVRPSLENSLRKLNLDYVDL 113
Cdd:cd19104  41 ALDLGINFFDTAPSYgdgKSEENLGRAL-----KG--LPAGPYITTKvrldPDDLGDIGGQIERSVEKSLKRLKRDSVDL 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 114 YLIHfpvslkpgNELLPKDEHGNLIFDTVD----LCDTWEAMEKCKDAGLAKSIGVSNF-NRRQLEMILNKPglkyKPVC 188
Cdd:cd19104 114 LQLH--------NRIGDERDKPVGGTLSTTdvlgLGGVADAFERLRSEGKIRFIGITGLgNPPAIRELLDSG----KFDA 181

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 189 NQVECHLyLNQS---------------KLLAYCKMND-----IVLVAYGALGTqrykyciNEDTPVLLDDPVLCAMAKKY 248
Cdd:cd19104 182 VQVYYNL-LNPSaaearprgwsaqdygGIIDAAAEHGvgvmgIRVLAAGALTT-------SLDRGREAPPTSDSDVAIDF 253

                       250       260
                ....*....|....*....|....*.
gi 19527284 249 KR-------------TPALIALRYQL 261
Cdd:cd19104 254 RRaaafralarewgeTLAQLAHRFAL 279

AKR_galDH

cd19163

L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called ...

16-220

4.32e-10

L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+).

Pssm-ID: 381389 [Multi-domain] Cd Length: 293 Bit Score: 59.49 E-value: 4.32e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  16 IPVLGFGTYA-------TEEhlkKKSMESTKIAIDVGFCHIDCSHLY---QNEEEIGQAiLSKIedgtvKREDIFYTSK- 84
Cdd:cd19163  13 VSKLGFGASPlggvfgpVDE---EEAIRTVHEALDSGINYIDTAPWYgqgRSETVLGKA-LKGI-----PRDSYYLATKv 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  85 -----LWSTS--HRPELVRPSLENSLRKLNLDYVDLYLIHFPvslkpgnellpkdEHGNLIfDTVdLCDTWEAMEKCKDA 157
Cdd:cd19163  84 gryglDPDKMfdFSAERITKSVEESLKRLGLDYIDIIQVHDI-------------EFAPSL-DQI-LNETLPALQKLKEE 148

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19527284 158 GLAKSIGVSNFNRRQLEMILNKPG------LKYkpvcnqveCHLYLNQS---KLLAYCKMNDIVLVAYGALG 220
Cdd:cd19163 149 GKVRFIGITGYPLDVLKEVLERSPvkidtvLSY--------CHYTLNDTsllELLPFFKEKGVGVINASPLS 212

AKR_AKR8A1-2

cd19077

AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding ...

91-297

4.96e-10

AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding members of aldo-keto reductase family 8 member A1-2 (AKR8A1-2), respectively. PLR (EC 1.1.1.65), also called PL reductase (PL-red), catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+).

Pssm-ID: 381303 [Multi-domain] Cd Length: 302 Bit Score: 59.56 E-value: 4.96e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  91 RPELVRPSLENSLRKLN-LDYVDLYlihfpvslkpgnELLPKDEHgnlifdtVDLCDTWEAMEKCKDAGLAKSIGVSNFN 169
Cdd:cd19077  92 SPEAVRKSIENILRALGgTKKIDIF------------EPARVDPN-------VPIEETIKALKELVKEGKIRGIGLSEVS 152

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 170 RRQLEMILnkpglKYKPV-CNQVECHLYLN---QSKLLAYCKMNDIVLVAYGALG----TQRYKycINEDTP-------- 233
Cdd:cd19077 153 AETIRRAH-----AVHPIaAVEVEYSLFSReieENGVLETCAELGIPIIAYSPLGrgllTGRIK--SLADIPegdfrrhl 225

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19527284 234 ------------VLLDdpVLCAMAKKYKRTPALIAL---RYQLDRGIVALAKSFNEERIRENMQVFDFQLASDDMKILD 297
Cdd:cd19077 226 drfngenfeknlKLVD--ALQELAEKKGCTPAQLALawiLAQSGPKIIPIPGSTTLERVEENLKAANVELTDEELKEIN 302

AKR_AKR13C1_2

cd19078

AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli ...

19-297

4.70e-09

AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli aldehyde reductase (AKR13C1) and Thermotoga maritima aldo-keto reductase (AKR13C2). Aldehyde reductase (EC 1.1.1.21), also called aldose reductase, is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides.

Pssm-ID: 381304 [Multi-domain] Cd Length: 301 Bit Score: 56.47 E-value: 4.70e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  19 LGFG----TYATEEHLKKKSM-ESTKIAIDVGFCHIDCSHLY---QNEEEIGQAILSKiedgtvkREDIFYTSKL-WSTS 89
Cdd:cd19078   7 IGLGcmgmSHGYGPPPDKEEMiELIRKAVELGITFFDTAEVYgpyTNEELVGEALKPF-------RDQVVIATKFgFKID 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  90 H----------RPELVRPSLENSLRKLNLDYVDLYLIHfpvslkpgnellpkdehgnLIFDTVDLCDTWEAMEKCKDAGL 159
Cdd:cd19078  80 GgkpgplgldsRPEHIRKAVEGSLKRLQTDYIDLYYQH-------------------RVDPNVPIEEVAGTMKELIKEGK 140

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 160 AKSIGVS----NFNRRqlemilnkpGLKYKPVCN-QVECHLYLN--QSKLLAYCKMNDIVLVAYGALGTQRYKYCINEDT 232
Cdd:cd19078 141 IRHWGLSeagvETIRR---------AHAVCPVTAvQSEYSMMWRepEKEVLPTLEELGIGFVPFSPLGKGFLTGKIDENT 211

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 233 P----------------------VLLDdpVLCAMAKKYKRTPALIALRYQLDRG--IVALAKSFNEERIRENMQVFDFQL 288
Cdd:cd19078 212 KfdegddraslprftpealeanqALVD--LLKEFAEEKGATPAQIALAWLLAKKpwIVPIPGTTKLSRLEENIGAADIEL 289


                ....*....
gi 19527284 289 ASDDMKILD 297
Cdd:cd19078 290 TPEELREIE 298

AKR_FDH

cd19162

D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S, ...

17-166

1.62e-08

D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.

Pssm-ID: 381388 [Multi-domain] Cd Length: 290 Bit Score: 54.67 E-value: 1.62e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  17 PVLGFGTYATEEHLKKKSMESTKI---AIDVGFCHIDCSHLY---QNEEEIGQAILSKiedgtvKREDIFYTSKL----- 85
Cdd:cd19162   1 PRLGLGAASLGNLARAGEDEAAATldaAWDAGIRYFDTAPLYglgLSERRLGAALARH------PRAEYVVSTKVgrlle 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  86 -----WSTSHRPEL------VRPSLENSLRKLNLDYVDLYLIHFPvslkpgnellpkDEHgnlifDTVDLCDTWEAMEKC 154
Cdd:cd19162  75 pgaagRPAGADRRFdfsadgIRRSIEASLERLGLDRLDLVFLHDP------------DRH-----LLQALTDAFPALEEL 137

                       170
                ....*....|..
gi 19527284 155 KDAGLAKSIGVS 166
Cdd:cd19162 138 RAEGVVGAIGVG 149

tas

PRK10625

putative aldo-keto reductase; Provisional

14-167

2.16e-08

putative aldo-keto reductase; Provisional

Pssm-ID: 236727 [Multi-domain] Cd Length: 346 Bit Score: 54.86 E-value: 2.16e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284   14 HSIP-------VLGFGTYA-TEEHLKKKSMESTKIAIDVGFCHIDCSHLYQ----------NEEEIGQAILSKiedgtVK 75
Cdd:PRK10625   4 HRIPhsslevsTLGLGTMTfGEQNSEADAHAQLDYAVAQGINLIDVAEMYPvpprpetqglTETYIGNWLAKR-----GS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284   76 REDIFYTSKLWSTSH------RPEL------VRPSLENSLRKLNLDYVDLYLIHFPVSlkpgnellPKDEHGNLIFD--- 140
Cdd:PRK10625  79 REKLIIASKVSGPSRnndkgiRPNQaldrknIREALHDSLKRLQTDYLDLYQVHWPQR--------PTNCFGKLGYSwtd 150

                        170       180       190
                 ....*....|....*....|....*....|
gi 19527284  141 ---TVDLCDTWEAMEKCKDAGLAKSIGVSN 167
Cdd:PRK10625 151 sapAVSLLETLDALAEQQRAGKIRYIGVSN 180

AKR_AKR10A1_2

cd19082

AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) ...

49-285

6.55e-08

AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) and Streptomyces glaucescens aldo-keto reductase (StrT) are founding members of aldo-keto reductase family 10 member A1 (AKR10A1) and A2 (AKR10A2). BlmT is bluensomycin aldo-keto reductase (AKR) and StrT is streptomycin AKR.

Pssm-ID: 381308 [Multi-domain] Cd Length: 291 Bit Score: 52.94 E-value: 6.55e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  49 IDCSHLYQNEEEIGQA--ILSKIEDGTVKREDIFYTSK-----LWSTS-HR--PELVRPSLENSLRKLNLDYVDLYLIH- 117
Cdd:cd19082  34 IDTARVYGDWVERGASerVIGEWLKSRGNRDKVVIATKgghpdLEDMSrSRlsPEDIRADLEESLERLGTDYIDLYFLHr 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 118 ----FPVSlkpgnELLpkdehgnlifdtvdlcdtwEAMEKCKDAGLAKSIGVSNFNrrqLEMIL---------NKPGlky 184
Cdd:cd19082 114 ddpsVPVG-----EIV-------------------DTLNELVRAGKIRAFGASNWS---TERIAeanayakahGLPG--- 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 185 kPVCNQV--------------ECHLYLNQSkLLAYCKMNDIVLVAYGALG----------------TQRYKYCiNEDTPV 234
Cdd:cd19082 164 -FAASSPqwslarpneppwpgPTLVAMDEE-MRAWHEENQLPVFAYSSQArgffskraaggaeddsELRRVYY-SEENFE 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 19527284 235 LLDdpVLCAMAKKYKRTPALIALRYQLDRG--IVALAKSFNEERIRENMQVFD 285
Cdd:cd19082 241 RLE--RAKELAEEKGVSPTQIALAYVLNQPfpTVPIIGPRTPEQLRDSLAAAD 291

AKR_AKR14A1_2

cd19089

AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate ...

20-265

1.10e-06

AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo. Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2). It catalyzes the conversion of 3-hydroxybutanal (3-HB) to 1,3-butanediol (1,3-BDO) by using NADPH as a cofactor.

Pssm-ID: 381315 [Multi-domain] Cd Length: 308 Bit Score: 49.56 E-value: 1.10e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  20 GFGTYATEEHLKKKSMEstkiAIDVGFCHID----CSHLYQNEEEIGQAILSkiEDGTVKREDIFYTSK----LW----- 86
Cdd:cd19089  21 NFGDYTSPEEARELLRT----AFDLGITHFDlannYGPPPGSAEENFGRILK--RDLRPYRDELVISTKagygMWpgpyg 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  87 STSHRPELVRpSLENSLRKLNLDYVDLYLIHFPvslkpgnellpkDehgnlifDTVDLCDTWEAMEKCKDAGLAKSIGVS 166
Cdd:cd19089  95 DGGSRKYLLA-SLDQSLKRMGLDYVDIFYHHRY------------D-------PDTPLEETMTALADAVRSGKALYVGIS 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 167 NFNRRQLEM---ILNKpgLKYKPVCNQVECHLyLNQS---KLLAYCKMNDIVLVAYGALG----TQRYKYCINED----- 231
Cdd:cd19089 155 NYPGAKARRaiaLLRE--LGVPLIIHQPRYSL-LDRWaedGLLEVLEEAGIGFIAFSPLAqgllTDKYLNGIPPDsrraa 231

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 19527284 232 -----TPVLLDDPV------LCAMAKKYKRTPALIALRYQL-DRGI 265
Cdd:cd19089 232 eskflTEEALTPEKleqlrkLNKIAAKRGQSLAQLALSWVLrDPRV 277

AKR_ARA2

cd19164

D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+) ...

39-205

1.17e-06

D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).

Pssm-ID: 381390 [Multi-domain] Cd Length: 298 Bit Score: 49.20 E-value: 1.17e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  39 KIAIDVGFCHIDCSHLYQNEEEI-GQAiLSKIEDGtVKREDIFYTSK-----LWSTSHRPELVRPSLENSLRKLNLDYVD 112
Cdd:cd19164  41 RRALELGIRAFDTSPYYGPSEIIlGRA-LKALRDE-FPRDTYFIITKvgrygPDDFDYSPEWIRASVERSLRRLHTDYLD 118

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 113 LYLIHfpvslkpgnellpkdehgNLIFDTVDlcDTWEAME---KCKDAGLAKSIGVSNFNRRQL----EMILNKPG---- 181
Cdd:cd19164 119 LVYLH------------------DVEFVADE--EVLEALKelfKLKDEGKIRNVGISGYPLPVLlrlaELARTTAGrpld 178

                       170       180
                ....*....|....*....|....*.
gi 19527284 182 --LKYkpvcnqveCHLYLNQSKLLAY 205
Cdd:cd19164 179 avLSY--------CHYTLQNTTLLAY 196

AKR_AKR9A_9B

cd19080

AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus ...

19-129

1.64e-06

AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD), are founding members of aldo-keto reductase family 9 member A1-3 (AKR9A1-3), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis. AAD (EC1.1.1.91) is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). The AKR9B family includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.

Pssm-ID: 381306 [Multi-domain] Cd Length: 307 Bit Score: 48.75 E-value: 1.64e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  19 LGFGTYATEEHLKKKSMESTKIA---IDVGFCHIDCSHLYQN---EEEIGQAILSKiedgtvkREDIFYTSKL-WST--- 88
Cdd:cd19080  15 LGTMTFGTEWGWGADREEARAMFdayVEAGGNFIDTANNYTNgtsERLLGEFIAGN-------RDRIVLATKYtMNRrpg 87

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 19527284  89 ------SHRPELVRpSLENSLRKLNLDYVDLYLIHFPVSLKPGNELL 129
Cdd:cd19080  88 dpnaggNHRKNLRR-SVEASLRRLQTDYIDLLYVHAWDFTTPVEEVM 133

PRK09912

L-glyceraldehyde 3-phosphate reductase; Provisional

13-298

1.70e-06

L-glyceraldehyde 3-phosphate reductase; Provisional

Pssm-ID: 182140 [Multi-domain] Cd Length: 346 Bit Score: 48.83 E-value: 1.70e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284   13 GHSIPVLGFGTYATEEHLKKKSMEST--KIAIDVGFCHIDCSHLY-----QNEEEIGQAILskiEDGTVKREDIFYTSK- 84
Cdd:PRK09912  22 GLRLPALSLGLWHNFGHVNALESQRAilRKAFDLGITHFDLANNYgpppgSAEENFGRLLR---EDFAAYRDELIISTKa 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284   85 ---LW-----STSHRPELVrPSLENSLRKLNLDYVDLYLIHFPvslkpgNELLPKDEhgnlifdtvdlcdTWEAMEKCKD 156
Cdd:PRK09912  99 gydMWpgpygSGGSRKYLL-ASLDQSLKRMGLEYVDIFYSHRV------DENTPMEE-------------TASALAHAVQ 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  157 AGLAKSIGVSNFN-RRQLEM--ILNK---PGLKYKPVCNQVecHLYLNQSKLLAYCKMNDIVLVAYGALG----TQRYKY 226
Cdd:PRK09912 159 SGKALYVGISSYSpERTQKMveLLREwkiPLLIHQPSYNLL--NRWVDKSGLLDTLQNNGVGCIAFTPLAqgllTGKYLN 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  227 CINED-------------TPVLLDDP------VLCAMAKKYKRTPALIALRYQL--DRGIVALAKSFNEERIRENMQVFD 285
Cdd:PRK09912 237 GIPQDsrmhregnkvrglTPKMLTEAnlnslrLLNEMAQQRGQSMAQMALSWLLkdERVTSVLIGASRAEQLEENVQALN 316

                        330
                 ....*....|....*....
gi 19527284  286 ---F---QLASDDMKILDG 298
Cdd:PRK09912 317 nltFsteELAQIDQHIADG 335

AKR_unchar

cd19752

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...

75-174

2.29e-06

Pssm-ID: 381391 [Multi-domain] Cd Length: 291 Bit Score: 48.48 E-value: 2.29e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  75 KREDIFYTSKL---------WSTSHR---PELVRPSLENSLRKLNLDYVDLYLIHfpvslkpgnellpkdehgnlIFD-T 141
Cdd:cd19752  65 NRDDVVIATKVgagprdpdgGPESPEglsAETIEQEIDKSLRRLGTDYIDLYYAH--------------------VDDrD 124

                        90       100       110
                ....*....|....*....|....*....|...
gi 19527284 142 VDLCDTWEAMEKCKDAGLAKSIGVSNFNRRQLE 174
Cdd:cd19752 125 TPLEETLEAFNELVKAGKVRAIGASNFAAWRLE 157

AKR_AKR13D1

cd19145

AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of ...

41-294

7.39e-05

AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.

Pssm-ID: 381371 [Multi-domain] Cd Length: 304 Bit Score: 43.96 E-value: 7.39e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  41 AIDVGFCHIDCSHLY---QNEEEIGQAILS----KIEDGTVKREDIFYTSKLWSTSHrPELVRPSLENSLRKLNLDYVDL 113
Cdd:cd19145  42 AFNSGVTFLDTSDIYgpnTNEVLLGKALKDgpreKVQLATKFGIHEIGGSGVEVRGD-PAYVRAACEASLKRLDVDYIDL 120

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 114 YLIHfpvslkpgnellpkdehgnLIFDTVDLCDTWEAMEKCKDAGLAKSIGVSNFN----RRQLEMilnkpglkyKPVCN 189
Cdd:cd19145 121 YYQH-------------------RIDTTVPIEITMGELKKLVEEGKIKYIGLSEASadtiRRAHAV---------HPITA 172

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284 190 -QVECHLYLN--QSKLLAYCKMNDIVLVAYGALGTQRYKYcinedTPVLLDDPV-------------------------L 241
Cdd:cd19145 173 vQLEWSLWTRdiEEEIIPTCRELGIGIVPYSPLGRGFFAG-----KAKLEELLEnsdvrkshprfqgenleknkvlyerV 247

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 19527284 242 CAMAKKYKRTPALIALRYQLDRG--IVALAKSFNEERIRENMQVFDFQLASDDMK 294
Cdd:cd19145 248 EALAKKKGCTPAQLALAWVLHQGedVVPIPGTTKIKNLNQNIGALSVKLTKEDLK 302

AKR_AKR6C1_2

cd19143

AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) ...

21-195

1.54e-04

AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa are founding members of aldo-keto reductase family 6 member C1 (AKR6C1) and C2 (AKR6C2), respectively. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.

Pssm-ID: 381369 [Multi-domain] Cd Length: 319 Bit Score: 42.97 E-value: 1.54e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  21 FGTYATEEHLKkksmESTKIAIDVGFCHIDCSHLYQN---EEEIGQAIlskiEDGTVKREDIFYTSKL-WSTSHRPE--- 93
Cdd:cd19143  24 FGNQVDVDEAK----ECMKAAYDAGVNFFDNAEVYANgqsEEIMGQAI----KELGWPRSDYVVSTKIfWGGGGPPPndr 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  94 -LVRPSL----ENSLRKLNLDYVDLYLIHFPVSLKPgnellpkdehgnlIFDTVdlcdtwEAMEKCKDAGLAKSIGVSNF 168
Cdd:cd19143  96 gLSRKHIvegtKASLKRLQLDYVDLVFCHRPDPATP-------------IEETV------RAMNDLIDQGKAFYWGTSEW 156

                       170       180       190
                ....*....|....*....|....*....|
gi 19527284 169 NRRQLE---MILNKPGLkYKPVCNQVECHL 195
Cdd:cd19143 157 SAQQIEeahEIADRLGL-IPPVMEQPQYNL 185

AKR_galDH-like

cd19153

L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ...

20-203

1.57e-04

L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).

Pssm-ID: 381379 [Multi-domain] Cd Length: 294 Bit Score: 42.91 E-value: 1.57e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  20 GFGTYATEEHLKKKSMESTKIAIDVGFCHIDCSHLYQN---EEEIGQAiLSKIEdgtVKREDIFYTSKL-------WSTS 89
Cdd:cd19153  21 ALGGVYGDGLEQDEAVAIVAEAFAAGINHFDTSPYYGAessEAVLGKA-LAALQ---VPRSSYTVATKVgryrdseFDYS 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  90 HrpELVRPSLENSLRKLNLDYVDLYLIHfpvslkpGNELLPKDEhgnlifdtvDLCDTWEAMEKCKDAGLAKSIGVSNFN 169
Cdd:cd19153  97 A--ERVRASVATSLERLHTTYLDVVYLH-------DIEFVDYDT---------LVDEALPALRTLKDEGVIKRIGIAGYP 158

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 19527284 170 RRQLEMILNK--PGlkyKPVCNQVECHLYLNQSKLL 203
Cdd:cd19153 159 LDTLTRATRRcsPG---SLDAVLSYCHLTLQDARLE 191

AKR_AKR15A

cd19152

AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum ...

17-165

1.58e-04

AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH), and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH(EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.

Pssm-ID: 381378 [Multi-domain] Cd Length: 308 Bit Score: 42.60 E-value: 1.58e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  17 PVLGFGT------YATEEHlkKKSMESTKIAIDVGFCHIDCSHLYQN---EEEIGQAILSKiedgtvKREDIFYTSKL-- 85
Cdd:cd19152   1 PKLGFGTaplgnlYEAVSD--EEAKATLVAAWDLGIRYFDTAPWYGAglsEERLGAALREL------GREDYVISTKVgr 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  86 ----------------WSTS-HRPEL------VRPSLENSLRKLNLDYVDLYLIHFPvslkpgNELLPKDEHGNLIFDTV 142
Cdd:cd19152  73 llvplqeveptfepgfWNPLpFDAVFdysydgILRSIEDSLQRLGLSRIDLLSIHDP------DEDLAGAESDEHFAQAI 146

                       170       180
                ....*....|....*....|...
gi 19527284 143 DlcDTWEAMEKCKDAGLAKSIGV 165
Cdd:cd19152 147 K--GAFRALEELREEGVIKAIGL 167

AKR_AKR6B1

cd19142

AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding ...

13-117

1.73e-04

AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding member of aldo-keto reductase family 6 member B1 (AKR6B1). Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase.

Pssm-ID: 381368 [Multi-domain] Cd Length: 325 Bit Score: 42.84 E-value: 1.73e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284  13 GHSIPVLGFGTYATEEH-LKKKSMES-TKIAIDVGFCHIDCSHLYQN---EEEIGqAILSKiedGTVKREDIFYTSKL-W 86
Cdd:cd19142  10 GLRVSNVGLGTWSTFSTaISEEQAEEiVTLAYENGINYFDTSDAFTSgqaETELG-RILKK---KGWKRSSYIVSTKIyW 85

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 19527284  87 STshRPE---LVRP----SLENSLRKLNLDYVDLYLIH 117
Cdd:cd19142  86 SY--GSEergLSRKhiieSVRASLRRLQLDYIDIVIIH 121

PLN02587

L-galactose dehydrogenase

11-203

2.25e-03

L-galactose dehydrogenase

Pssm-ID: 178198 [Multi-domain] Cd Length: 314 Bit Score: 39.38 E-value: 2.25e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284   11 NDGHSIPVLGFGT--------YATEEhlkkKSMESTKIAIDVGFCHIDCSHLYQNEeeIGQAILSK-IEDGTVKREDIFY 81
Cdd:PLN02587   6 STGLKVSSVGFGAsplgsvfgPVSEE----DAIASVREAFRLGINFFDTSPYYGGT--LSEKVLGKaLKALGIPREKYVV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527284   82 TSKLWSTSH----RPELVRPSLENSLRKLNLDYVDLYLIHfpvslkpgnellpKDEHGNLifDTVdLCDTWEAMEKCKDA 157
Cdd:PLN02587  80 STKCGRYGEgfdfSAERVTKSVDESLARLQLDYVDILHCH-------------DIEFGSL--DQI-VNETIPALQKLKES 143

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 19527284  158 GLAKSIGVSNFNRRQLEMILNK--PG-----LKYkpvcnqveCHLYLNQSKLL 203
Cdd:PLN02587 144 GKVRFIGITGLPLAIFTYVLDRvpPGtvdviLSY--------CHYSLNDSSLE 188

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01