NCBI Conserved Domain Search

Conserved domains on [gi|19527294|ref|NP_598833|]

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3-alpha-hydroxysteroid dehydrogenase [Mus musculus]

Protein Classification

aldo/keto reductase( domain architecture ID 14442631)

aldo/keto reductase is a soluble NAD(P)(H) oxidoreductase that catalyzes the reduction of aldehydes and ketones to their corresponding primary and secondary alcohols

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

AKR_AKR1C1-35

cd19108

AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) ...

6-308

0e+00

AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) includes AKR1C1 (20-alpha-hydroxysteroid dehydrogenase, also known as 20alpha-HSD), AKR1C2 (3alpha-HSD type 3), AKR1C3 (17beta-HSD type 5), and AKR1C4 (3alpha-HSD type 1) from Homo sapiens; AKR1C5 (20alpha-HSD, also known as prostaglandin-E(2) 9-reductase) from Rattus norvegicus (ovary); AKR1C6 (estradiol 17beta-HSD type 5) from Mus musculus; AKR1C7 (prostaglandin F synthase 1 or PGF1) from Bos taurus (lung); AKR1C8 (20alpha-HSD) from Rattus norvegicus (ovary); AKR1C9 (3alpha-HSD) from Rattus norvegicus (liver); AKR1C10a (Rho crystallin) from Rana temporaria and AKR1C10b (Rho crystallin) from Rana catesbeina; AKR1C11 (prostaglandin F synthase 2 or PGF2) from Bos taurus (liver); AKR1C12 (aldo-keto reductase or AKR), AKR1C13 (interleukin-3-regulated AKR), and AKR1C14 (3alpha-HSD) from Mus musculus; AKR1C15 (NADPH-dependent reductase), AKR1C16 (NAD+-preferring 3alpha/17beta/20alpha-HSD), and AKR1C17 (NAD+-dependent 3alpha-HSD) from Rattus norvegicus; AKR1C18 (20alpha-HSD), AKR1C19 (3-hydroxybutyrate dehydrogenase or 3HB dehydrogenase), AKR1C20 (3alpha(17beta)-HSD), AKR1C21 (3(17)alpha-HSD), AKR1C22 (dihydrodiol dehydrogenase or DD) from Mus musculus; AKR1C23 (20alpha-HSD) from Equus caballus; AKR1C24 (NAD+-dependent 17beta-HSD) from Rattus norvegicus; AKR1C25 (3(20)alpha-HSD) from Macaca fuscata; AKR1C26 (identical to morphine 6-dehydrogenase or M6DH, acts as NAD(+)-dependent 3alpha/17beta-HSD), AKR1C27/AKR1C28 (NAD(+)-dependent 3alpha/17beta-HSDs), AKR1C29 (identical to 3-hydroxyhexobarbital dehydrogenase or 3HBD, acts as NADPH-preferring reductase with 3alpha/3beta/17beta/20alpha-HSD activity), AKR1C30 (identical to naloxone reductase type 1 and acts as 17beta-HSD), AKR1C31 (3alpha/17beta/20alpha-HSD), AKR1C32 (identical to loxoprofen reductase and acts as 3alpha/20alpha-HSD), and AKR1C33 (identical to naloxone reductase type 2 and mainly acts as 3alpha-HSD) from Oryctolagus cuniculus; AKR1C34 (NAD+-dependent morphine 6-dehydrogenase or M6DH with 3beta/17beta/20alpha-HSD activity) and AKR1C35 (NAD+-dependent dehydrogenase with 3(17)beta-HSD activity) from Mesocricetus auratus.

Pssm-ID: 381334 [Multi-domain] Cd Length: 303 Bit Score: 668.55 E-value: 0e+00

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294   6 PRVVLNDGHFIPALGFGTTVPDKVPKDELIKATKIAIDTGFRHFDSAYLYQIEEEVGQAIRSKIEDGTVKREDIFYTSKL 85
Cdd:cd19108   1 QRVKLNDGHFIPVLGFGTYAPEEVPKSKALEATKLAIDAGFRHIDSAYLYQNEEEVGQAIRSKIADGTVKREDIFYTSKL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  86 WSTFHRPELVRSCLEKTLKNAQLDYVDLYIIHFPMALQPGDKLFPRDEHGKLLAEAVDLCDTWEAMEKCKDAGLAKSIGV 165
Cdd:cd19108  81 WCTFHRPELVRPALEKSLKKLQLDYVDLYLIHFPVALKPGEELFPKDENGKLIFDTVDLCATWEAMEKCKDAGLAKSIGV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 166 SNFNFRQLETILNKPGLKYKPVCNQVECHLYLNQSQMLDYCKSKDIILVSYCTLGSSRDKIWVDQKSPVLLDDPVLCAMA 245
Cdd:cd19108 161 SNFNRRQLEMILNKPGLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAYSALGSQRDKEWVDQNSPVLLEDPVLCALA 240

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19527294 246 NKYKQTPALIAIRYQLQRGIVVLTRSFKEKRIKEFMKVFEFQLASEDMKVLDGLHRNLRYNTA 308
Cdd:cd19108 241 KKHKRTPALIALRYQLQRGVVVLAKSFNEKRIKENLQVFEFQLTSEDMKALDGLNRNLRYLPA 303

Name

Accession

Description

Interval

E-value

AKR_AKR1C1-35

cd19108

AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) ...

6-308

0e+00

Pssm-ID: 381334 [Multi-domain] Cd Length: 303 Bit Score: 668.55 E-value: 0e+00

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294   6 PRVVLNDGHFIPALGFGTTVPDKVPKDELIKATKIAIDTGFRHFDSAYLYQIEEEVGQAIRSKIEDGTVKREDIFYTSKL 85
Cdd:cd19108   1 QRVKLNDGHFIPVLGFGTYAPEEVPKSKALEATKLAIDAGFRHIDSAYLYQNEEEVGQAIRSKIADGTVKREDIFYTSKL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  86 WSTFHRPELVRSCLEKTLKNAQLDYVDLYIIHFPMALQPGDKLFPRDEHGKLLAEAVDLCDTWEAMEKCKDAGLAKSIGV 165
Cdd:cd19108  81 WCTFHRPELVRPALEKSLKKLQLDYVDLYLIHFPVALKPGEELFPKDENGKLIFDTVDLCATWEAMEKCKDAGLAKSIGV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 166 SNFNFRQLETILNKPGLKYKPVCNQVECHLYLNQSQMLDYCKSKDIILVSYCTLGSSRDKIWVDQKSPVLLDDPVLCAMA 245
Cdd:cd19108 161 SNFNRRQLEMILNKPGLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAYSALGSQRDKEWVDQNSPVLLEDPVLCALA 240

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19527294 246 NKYKQTPALIAIRYQLQRGIVVLTRSFKEKRIKEFMKVFEFQLASEDMKVLDGLHRNLRYNTA 308
Cdd:cd19108 241 KKHKRTPALIALRYQLQRGVVVLAKSFNEKRIKENLQVFEFQLTSEDMKALDGLNRNLRYLPA 303

ARA1

COG0656

Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ...

12-305

2.60e-100

Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];

Pssm-ID: 440421 [Multi-domain] Cd Length: 259 Bit Score: 295.43 E-value: 2.60e-100

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  12 DGHFIPALGFGTTvpdKVPKDELIKATKIAIDTGFRHFDSAYLYQIEEEVGQAIRskiEDGtVKREDIFYTSKLWSTFHR 91
Cdd:COG0656   1 NGVEIPALGLGTW---QLPGEEAAAAVRTALEAGYRHIDTAAMYGNEEGVGEAIA---ASG-VPREELFVTTKVWNDNHG 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  92 PELVRSCLEKTLKNAQLDYVDLYIIHFPMAlqpgdklfprdehgkllaeaVDLCDTWEAMEKCKDAGLAKSIGVSNFNFR 171
Cdd:COG0656  74 YDDTLAAFEESLERLGLDYLDLYLIHWPGP--------------------GPYVETWRALEELYEEGLIRAIGVSNFDPE 133

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 172 QLETILNKPGlkYKPVCNQVECHLYLNQSQMLDYCKSKDIILVSYCTLGSSRdkiwvdqkspvLLDDPVLCAMANKYKQT 251
Cdd:COG0656 134 HLEELLAETG--VKPAVNQVELHPYLQQRELLAFCREHGIVVEAYSPLGRGK-----------LLDDPVLAEIAEKHGKT 200

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 19527294 252 PALIAIRYQLQRGIVVLTRSFKEKRIKEFMKVFEFQLASEDMKVLDGLHRNLRY 305
Cdd:COG0656 201 PAQVVLRWHLQRGVVVIPKSVTPERIRENLDAFDFELSDEDMAAIDALDRGERL 254

Aldo_ket_red

pfam00248

Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ...

19-299

4.22e-57

Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.

Pssm-ID: 425554 [Multi-domain] Cd Length: 290 Bit Score: 186.36 E-value: 4.22e-57

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294    19 LGFGT----TVPDKVPKDELIKATKIAIDTGFRHFDSAYLYQI---EEEVGQAIRSKiedgTVKREDIFYTSKL------ 85
Cdd:pfam00248   1 IGLGTwqlgGGWGPISKEEALEALRAALEAGINFIDTAEVYGDgksEELLGEALKDY----PVKRDKVVIATKVpdgdgp 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294    86 WSTFHRPELVRSCLEKTLKNAQLDYVDLYIIHFPmalqpgdklFPrdehgkllaeAVDLCDTWEAMEKCKDAGLAKSIGV 165
Cdd:pfam00248  77 WPSGGSKENIRKSLEESLKRLGTDYIDLYYLHWP---------DP----------DTPIEETWDALEELKKEGKIRAIGV 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294   166 SNFNFRQLETILNKPglKYKPVCNQVECHLY--LNQSQMLDYCKSKDIILVSYCTLGS----------------SRDKIW 227
Cdd:pfam00248 138 SNFDAEQIEKALTKG--KIPIVAVQVEYNLLrrRQEEELLEYCKKNGIPLIAYSPLGGglltgkytrdpdkgpgERRRLL 215

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19527294   228 VDQKSPVLLDDPVLCAMANKYKQTPALIAIRY--QLQRGIVVLTRSFKEKRIKEFMKVFEFQLASEDMKVLDGL 299
Cdd:pfam00248 216 KKGTPLNLEALEALEEIAKEHGVSPAQVALRWalSKPGVTIPIPGASNPEQLEDNLGALEFPLSDEEVARIDEL 289

dkgA

PRK11565

2,5-didehydrogluconate reductase DkgA;

3-293

1.05e-55

2,5-didehydrogluconate reductase DkgA;

Pssm-ID: 183203 [Multi-domain] Cd Length: 275 Bit Score: 182.19 E-value: 1.05e-55

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294    3 SVSPRVVLNDGHFIPALGFGTTvpdKVPKDELIKATKIAIDTGFRHFDSAYLYQIEEEVGQAIRSkiedGTVKREDIFYT 82
Cdd:PRK11565   2 ANPTVIKLQDGNVMPQLGLGVW---QASNEEVITAIHKALEVGYRSIDTAAIYKNEEGVGKALKE----ASVAREELFIT 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294   83 SKLWSTFHRPelVRSCLEKTLKNAQLDYVDLYIIHFPMALQpgdklfprDEHgkllaeavdlCDTWEAMEKCKDAGLAKS 162
Cdd:PRK11565  75 TKLWNDDHKR--PREALEESLKKLQLDYVDLYLMHWPVPAI--------DHY----------VEAWKGMIELQKEGLIKS 134

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  163 IGVSNFNFRQLETILNKPGLKykPVCNQVECHLYLNQSQMLDYCKSKDIILVSYCTLGssrdkiwvdQKSPVLLDDPVLC 242
Cdd:PRK11565 135 IGVCNFQIHHLQRLIDETGVT--PVINQIELHPLMQQRQLHAWNATHKIQTESWSPLA---------QGGKGVFDQKVIR 203

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 19527294  243 AMANKYKQTPALIAIRYQLQRGIVVLTRSFKEKRIKEFMKVFEFQLASEDM 293
Cdd:PRK11565 204 DLADKYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVFDFRLDKDEL 254

Name

Accession

Description

Interval

E-value

AKR_AKR1C1-35

cd19108

AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) ...

6-308

0e+00

Pssm-ID: 381334 [Multi-domain] Cd Length: 303 Bit Score: 668.55 E-value: 0e+00

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294   6 PRVVLNDGHFIPALGFGTTVPDKVPKDELIKATKIAIDTGFRHFDSAYLYQIEEEVGQAIRSKIEDGTVKREDIFYTSKL 85
Cdd:cd19108   1 QRVKLNDGHFIPVLGFGTYAPEEVPKSKALEATKLAIDAGFRHIDSAYLYQNEEEVGQAIRSKIADGTVKREDIFYTSKL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  86 WSTFHRPELVRSCLEKTLKNAQLDYVDLYIIHFPMALQPGDKLFPRDEHGKLLAEAVDLCDTWEAMEKCKDAGLAKSIGV 165
Cdd:cd19108  81 WCTFHRPELVRPALEKSLKKLQLDYVDLYLIHFPVALKPGEELFPKDENGKLIFDTVDLCATWEAMEKCKDAGLAKSIGV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 166 SNFNFRQLETILNKPGLKYKPVCNQVECHLYLNQSQMLDYCKSKDIILVSYCTLGSSRDKIWVDQKSPVLLDDPVLCAMA 245
Cdd:cd19108 161 SNFNRRQLEMILNKPGLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAYSALGSQRDKEWVDQNSPVLLEDPVLCALA 240

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19527294 246 NKYKQTPALIAIRYQLQRGIVVLTRSFKEKRIKEFMKVFEFQLASEDMKVLDGLHRNLRYNTA 308
Cdd:cd19108 241 KKHKRTPALIALRYQLQRGVVVLAKSFNEKRIKENLQVFEFQLTSEDMKALDGLNRNLRYLPA 303

AKR_AKR1D1-3

cd19109

AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes ...

13-319

7.97e-167

AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes 3-oxo-5-beta-steroid 4-dehydrogenase (EC 1.3.1.3) from Homo sapiens (AKR1D1), Rattus norvegicus (liver, AKR1D2), and Oryctolagus cuniculus (AKR1D3). 3-oxo-5-beta-steroid 4-dehydrogenase, also called delta(4)-3-ketosteroid 5-beta-reductase (EC 1.3.99.6), or delta(4)-3-oxosteroid 5-beta-reductase, or 5-beta-reductase, efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites.

Pssm-ID: 381335 [Multi-domain] Cd Length: 308 Bit Score: 466.20 E-value: 7.97e-167

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  13 GHFIPALGFGT-TVPDKVPKDELIKATKIAIDTGFRHFDSAYLYQIEEEVGQAIRSKIEDGTVKREDIFYTSKLWSTFHR 91
Cdd:cd19109   1 GNSIPIIGLGTySEPKTTPKGACAEAVKVAIDTGYRHIDGAYIYQNEHEVGQAIREKIAEGKVKREDIFYCGKLWNTCHP 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  92 PELVRSCLEKTLKNAQLDYVDLYIIHFPMALQPGDKLFPRDEHGKLLAEAVDLCDTWEAMEKCKDAGLAKSIGVSNFNFR 171
Cdd:cd19109  81 PELVRPTLERTLKVLQLDYVDLYIIEMPMAFKPGDEIYPRDENGKWLYHKTNLCATWEALEACKDAGLVKSIGVSNFNRR 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 172 QLETILNKPGLKYKPVCNQVECHLYLNQSQMLDYCKSKDIILVSYCTLGSSRDKIWVDQKSPVLLDDPVLCAMANKYKQT 251
Cdd:cd19109 161 QLELILNKPGLKHKPVSNQVECHPYFTQPKLLEFCQQHDIVIVAYSPLGTCRDPIWVNVSSPPLLEDPLLNSIGKKYNKT 240

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19527294 252 PALIAIRYQLQRGIVVLTRSFKEKRIKEFMKVFEFQLASEDMKVLDGLHRNLRYNTASYFDDHPNHPF 319
Cdd:cd19109 241 AAQVVLRFNIQRGVVVIPKSFNPERIKENFQIFDFSLTEEEMKDIEALNKNVRYVELLMWRDHPEYPF 308

AKR_AKR1B1-19

cd19107

AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase ...

16-323

1.01e-126

AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase (AR, EC 1.1.1.21) from Homo sapiens (AKR1B1), Oryctolagus cuniculus (kidney, AKR1B2), Mus musculus (AKR1B3), Rattus norvegicus (lens, AKR1B4), Bos taurus (lens/testis, AKR1B5), and Sus scrofa (lens, AKR1B6), aldose reductase-related protein 1 (ALD1, EC1.1.1.21) from Mus musculus (AKR1B7), Rattus norvegicus (AKR1B14), and Homo sapiens (AKR1B15), Mus musculus fibroblast growth factor induced protein (FR-1 or AKR1B8, EC 1.1.1.21), Cricetulus griseus aldose reductase-related protein 2 (ALD2 or AKR1B9, EC 1.1.1.21), aldose reductase-like from Homo sapiens (ARL-1 or AKR1B10) and Rattus norvegicus (AKR1B13), aldo-keto reductase from Gallus domesticus (eye, tongue, esophagus, AKR1B12), and Oryctolagus cuniculus AR-like protein (3beta-HSD, AKR1B19). AR, also called aldehyde reductase, catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. ALD1 reduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols. It may play a role in the metabolism of xenobiotic aromatic aldehydes. FR-1, also called aldose reductase-related protein 2, or fibroblast growth factor-regulated protein (FGFRP), is induced by fibroblast growth factor-1. It may play a role in the regulation of the cell cycle. FR-1 belongs to the NADPH-dependent aldo-keto reductase family. ALD2 is an inducible aldo-keto reductase with a preference for aliphatic substrates. It can also act on small aromatic aldehydes, steroid aldehydes and some ketone substrates. ARL-1, also called aldose reductase-like, or aldose reductase-related protein (ARP), or small intestine reductase, or SI reductase, acts as all-trans-retinaldehyde reductase that can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). It may be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. AKR1B15, also called estradiol 17-beta-dehydrogenase AKR1B15, is a mitochondrial aldo-keto reductase that catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs. It has a strong selectivity towards NADP(H). AKR1B19 is aldose reductase-like that may show 3-beta-hydroxysteroid dehydrogenase (3beta-HSD) activity.

Pssm-ID: 381333 [Multi-domain] Cd Length: 307 Bit Score: 364.43 E-value: 1.01e-126

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  16 IPALGFGTTvpdKVPKDELIKATKIAIDTGFRHFDSAYLYQIEEEVGQAIRSKIEDGTVKREDIFYTSKLWSTFHRPELV 95
Cdd:cd19107   4 MPILGLGTW---KSPPGQVTEAVKVAIDAGYRHIDCAYVYQNENEVGEAIQEKIKEQVVKREDLFIVSKLWCTFHEKGLV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  96 RSCLEKTLKNAQLDYVDLYIIHFPMALQPGDKLFPRDEHGKLLAEAVDLCDTWEAMEKCKDAGLAKSIGVSNFNFRQLET 175
Cdd:cd19107  81 KGACQKTLSDLKLDYLDLYLIHWPTGFKPGKELFPLDESGNVIPSDTTFLDTWEAMEELVDEGLVKAIGVSNFNHLQIER 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 176 ILNKPGLKYKPVCNQVECHLYLNQSQMLDYCKSKDIILVSYCTLGSSrDKIWVDQKSPVLLDDPVLCAMANKYKQTPALI 255
Cdd:cd19107 161 ILNKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSP-DRPWAKPEDPSLLEDPKIKEIAAKHNKTTAQV 239

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19527294 256 AIRYQLQRGIVVLTRSFKEKRIKEFMKVFEFQLASEDMKVLDGLHRNLRYNTASYFDDHPNHPFTDEY 323
Cdd:cd19107 240 LIRFPIQRNLVVIPKSVTPERIAENFKVFDFELSSEDMATILSFNRNWRACALLSCSSHKDYPFHAEY 307

AKR_AKR1A1-4

cd19106

AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol ...

10-305

2.39e-119

AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol dehydrogenase [NADP(+)] (ALR, EC 1.1.1.2) from Homo sapiens (AKR1A1), Sus scrofa (AKR1A2), Rattus norvegicus (liver, AKR1A3), and Mus musculus (AKR1A4). ALR, also known as aldehyde reductase, or ALDR1, catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid.

Pssm-ID: 381332 [Multi-domain] Cd Length: 305 Bit Score: 345.52 E-value: 2.39e-119

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  10 LNDGHFIPALGFGTTvpdKVPKDELIKATKIAIDTGFRHFDSAYLYQIEEEVGQAIRSKI-EDGTVKREDIFYTSKLWST 88
Cdd:cd19106   1 LHTGQKMPLIGLGTW---KSKPGQVKAAVKYALDAGYRHIDCAAVYGNEQEVGEALKEKVgPGKAVPREDLFVTSKLWNT 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  89 FHRPELVRSCLEKTLKNAQLDYVDLYIIHFPMALQPGDKLFPRDEHGKLLAEAVDLCDTWEAMEKCKDAGLAKSIGVSNF 168
Cdd:cd19106  78 KHHPEDVEPALRKTLKDLQLDYLDLYLIHWPYAFERGDNPFPKNPDGTIRYDSTHYKETWKAMEKLVDKGLVKAIGLSNF 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 169 NFRQLETILNKPglKYKPVCNQVECHLYLNQSQMLDYCKSKDIILVSYCTLGSSrDKIWVDQKSPVLLDDPVLCAMANKY 248
Cdd:cd19106 158 NSRQIDDILSVA--RIKPAVLQVECHPYLAQNELIAHCKARGLVVTAYSPLGSP-DRPWAKPDEPVLLEEPKVKALAKKY 234

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 19527294 249 KQTPALIAIRYQLQRGIVVLTRSFKEKRIKEFMKVFEFQLASEDMKVLDGLHRNLRY 305
Cdd:cd19106 235 NKSPAQILLRWQVQRGVVVIPKSVTPSRIKQNIQVFDFTLSPEEMKQLDALNRNWRY 291

AKR_AKR2E1-5

cd19116

AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a ...

6-305

2.45e-117

AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a founding member of aldo-keto reductase family 2 member E4 (AKR2E4). It is a NADP-dependent oxidoreductase with high 3-dehydroecdysone reductase activity. It may play a role in the regulation of molting and has lower activity with phenylglyoxal and isatin (in vitro). This family also includes 3-dehydroecdysone 3b-reductase from Spodoptera littoralis and Trichoplusia ni, DL-glyceraldehyde reductase from Drosophila melanogaster, aldo-keto reductase from Bombyx mori, which correspond to aldo-keto reductase family 2 member E1, E2, E3 and E5 (AKR2E1/2/3/5), respectively.

Pssm-ID: 381342 [Multi-domain] Cd Length: 292 Bit Score: 340.03 E-value: 2.45e-117

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294   6 PRVVLNDGHFIPALGFGTTvpDKVPKDELIKATKIAIDTGFRHFDSAYLYQIEEEVGQAIRSKIEDGTVKREDIFYTSKL 85
Cdd:cd19116   1 PTIKLNDGNEIPAIALGTW--KLKDDEGVRQAVKHAIEAGYRHIDTAYLYGNEAEVGEAIREKIAEGVVKREDLFITTKL 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  86 WSTFHRPELVRSCLEKTLKNAQLDYVDLYIIHFPMALQPGDKlfpRDEHGKLLAEAVDLCDTWEAMEKCKDAGLAKSIGV 165
Cdd:cd19116  79 WNSYHEREQVEPALRESLKRLGLDYVDLYLIHWPVAFKENND---SESNGDGSLSDIDYLETWRGMEDLVKLGLTRSIGV 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 166 SNFNFRQLETILNkpGLKYKPVCNQVECHLYLNQSQMLDYCKSKDIILVSYCTLGS-SRDKIWvdqKSPVLLDDPVLCAM 244
Cdd:cd19116 156 SNFNSEQINRLLS--NCNIKPAVNQIEVHPTLTQEKLVAYCQSNGIVVMAYSPFGRlVPRGQT---NPPPRLDDPTLVAI 230

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19527294 245 ANKYKQTPALIAIRYQLQRGIVVLTRSFKEKRIKEFMKVFEFQLASEDMKVLDGLHRNLRY 305
Cdd:cd19116 231 AKKYGKTTAQIVLRYLIDRGVVPIPKSSNKKRIKENIDIFDFQLTPEEVAALNSFNTNQRV 291

AKR_AKR1E1-2

cd19110

AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1, ...

16-323

8.48e-114

AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1,5-anhydro-D-fructose reductase (EC 1.1.1.263) from Mus musculus (liver, AKR1E1) and Homo sapiens (AKR1E2). 1,5-anhydro-D-fructose reductase), also called AF reductase, or aldo-keto reductase family 1 member C-like protein 2 (AKR1CL2), catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol. AKR1E2 is a testis aldo-keto reductase (tAKR), which is also known as testis-specific protein (TSP), or LoopADR.

Pssm-ID: 381336 [Multi-domain] Cd Length: 301 Bit Score: 331.54 E-value: 8.48e-114

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  16 IPALGFGTTvpdKVPKDELIKATKIAIDTGFRHFDSAYLYQIEEEVGQAIRSKIEDGTVKREDIFYTSKLWSTFHRPELV 95
Cdd:cd19110   4 IPAVGLGTW---KASPGEVTEAVKVAIDAGYRHFDCAYLYHNESEVGAGIREKIKEGVVRREDLFIVSKLWCTCHKKSLV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  96 RSCLEKTLKNAQLDYVDLYIIHFPMALQPGDKLFPRDEHGKLLAEAVDLCDTWEAMEKCKDAGLAKSIGVSNFNFRQLET 175
Cdd:cd19110  81 KTACTRSLKALKLNYLDLYLIHWPMGFKPGEPDLPLDRSGMVIPSDTDFLDTWEAMEDLVIEGLVKNIGVSNFNHEQLER 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 176 ILNKPGLKYKPVCNQVECHLYLNQSQMLDYCKSKDIILVSYCTLGSSRDKIwvdqkspVLLDDPVLCAMANKYKQTPALI 255
Cdd:cd19110 161 LLNKPGLRVKPVTNQIECHPYLTQKKLISFCQSRNVSVTAYRPLGGSCEGV-------DLIDDPVIQRIAKKHGKSPAQI 233

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19527294 256 AIRYQLQRGIVVLTRSFKEKRIKEFMKVFEFQLASEDMKVLDGLHRNLRYNTASYFDDHPNHPFTDEY 323
Cdd:cd19110 234 LIRFQIQRNVIVIPKSVTPSRIKENIQVFDFELTEHDMDNLLSLDRNLRLATFPITENHKDYPFHIEY 301

AKR_AKR1-5-like

cd19071

AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ...

16-297

3.27e-112

AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.

Pssm-ID: 381297 [Multi-domain] Cd Length: 251 Bit Score: 325.59 E-value: 3.27e-112

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  16 IPALGFGTtvpDKVPKDELIKATKIAIDTGFRHFDSAYLYQIEEEVGQAIRSKIedgtVKREDIFYTSKLWSTFHRPELV 95
Cdd:cd19071   1 MPLIGLGT---YKLKPEETAEAVLAALEAGYRHIDTAAAYGNEAEVGEAIRESG----VPREELFITTKLWPTDHGYERV 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  96 RSCLEKTLKNAQLDYVDLYIIHFPMALQPGDklfprdehgkllaEAVDLCDTWEAMEKCKDAGLAKSIGVSNFNFRQLET 175
Cdd:cd19071  74 REALEESLKDLGLDYLDLYLIHWPVPGKEGG-------------SKEARLETWRALEELVDEGLVRSIGVSNFNVEHLEE 140

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 176 ILNKPglKYKPVCNQVECHLYLNQSQMLDYCKSKDIILVSYCTLGSSRDKiwvdqkspvLLDDPVLCAMANKYKQTPALI 255
Cdd:cd19071 141 LLAAA--RIKPAVNQIELHPYLQQKELVEFCKEHGIVVQAYSPLGRGRRP---------LLDDPVLKEIAKKYGKTPAQV 209

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 19527294 256 AIRYQLQRGIVVLTRSFKEKRIKEFMKVFEFQLASEDMKVLD 297
Cdd:cd19071 210 LLRWALQRGVVVIPKSSNPERIKENLDVFDFELSEEDMAAID 251

AKR_AKR1G1_CeAKR

cd19154

Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding ...

5-304

3.24e-107

Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.

Pssm-ID: 381380 [Multi-domain] Cd Length: 303 Bit Score: 314.74 E-value: 3.24e-107

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294   5 SPRVVLNDGHFIPALGFGTTvpdKVPKDELIKATKIAIDTGFRHFDSAYLYQIEEEVGQAIRSKIEDGTVKREDIFYTSK 84
Cdd:cd19154   1 SASITLSNGVKMPLIGLGTW---QSKGAEGITAVRTALKAGYRLIDTAFLYQNEEAIGEALAELLEEGVVKREDLFITTK 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  85 LWSTFHRPELVRSCLEKTLKNAQLDYVDLYIIHFPMALQPGDKLFPRDEHGKLLAEAVDLCDTWEAMEKCKDAGLAKSIG 164
Cdd:cd19154  78 LWTHEHAPEDVEEALRESLKKLQLEYVDLYLIHAPAAFKDDEGESGTMENGMSIHDAVDVEDVWRGMEKVYDEGLTKAIG 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 165 VSNFNFRQLETILNKPglKYKPVCNQVECHLYLNQSQMLDYCKSKDIILVSYCTLGS----SRDKIWVDQKSPVLLDDPV 240
Cdd:cd19154 158 VSNFNNDQIQRILDNA--RVKPHNNQVECHLYFPQKELVEFCKKHNISVTSYATLGSpgraNFTKSTGVSPAPNLLQDPI 235

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19527294 241 LCAMANKYKQTPALIAIRYQLQRGIVVLTRSFKEKRIKEFMKVFEFQLASEDMKVLDGLHRNLR 304
Cdd:cd19154 236 VKAIAEKHGKTPAQVLLRYLLQRGIAVIPKSATPSRIKENFNIFDFSLSEEDMATLEEIEKSLR 299

AKR_AKR3G1

cd19123

AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a ...

10-305

3.55e-106

AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a founding member of aldo-keto reductase family 3 member G1 (AKR3G1). It is an aldo/keto reductase that catalyzes the NADPH-dependent reduction of aldehyde- and ketone-groups of different classes of carbonyl compounds to the corresponding alcohols.

Pssm-ID: 381349 [Multi-domain] Cd Length: 297 Bit Score: 312.04 E-value: 3.55e-106

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  10 LNDGHFIPALGFGTTvpdKVPKDELIKATKIAIDTGFRHFDSAYLYQIEEEVGQAIRSKIEDGTVKREDIFYTSKLWSTF 89
Cdd:cd19123   6 LSNGDLIPALGLGTW---KSKPGEVGQAVKQALEAGYRHIDCAAIYGNEAEIGAALAEVFKEGKVKREDLWITSKLWNNS 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  90 HRPELVRSCLEKTLKNAQLDYVDLYIIHFPMALQPGdKLFPRDEHGKLLAEAVDLCDTWEAMEKCKDAGLAKSIGVSNFN 169
Cdd:cd19123  83 HAPEDVLPALEKTLADLQLDYLDLYLMHWPVALKKG-VGFPESGEDLLSLSPIPLEDTWRAMEELVDKGLCRHIGVSNFS 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 170 FRQLETILNKPglKYKPVCNQVECHLYLNQSQMLDYCKSKDIILVSYCTLGS-SRDKIWVDQKSPVLLDDPVLCAMANKY 248
Cdd:cd19123 162 VKKLEDLLATA--RIKPAVNQVELHPYLQQPELLAFCRDNGIHLTAYSPLGSgDRPAAMKAEGEPVLLEDPVINKIAEKH 239

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 19527294 249 KQTPALIAIRYQLQRGIVVLTRSFKEKRIKEFMKVFEFQLASEDMKVLDGLHRNLRY 305
Cdd:cd19123 240 GASPAQVLIAWAIQRGTVVIPKSVNPERIQQNLEAAEVELDASDMATIAALDRHHRY 296

ARA1

COG0656

Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ...

12-305

2.60e-100

Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];

Pssm-ID: 440421 [Multi-domain] Cd Length: 259 Bit Score: 295.43 E-value: 2.60e-100

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  12 DGHFIPALGFGTTvpdKVPKDELIKATKIAIDTGFRHFDSAYLYQIEEEVGQAIRskiEDGtVKREDIFYTSKLWSTFHR 91
Cdd:COG0656   1 NGVEIPALGLGTW---QLPGEEAAAAVRTALEAGYRHIDTAAMYGNEEGVGEAIA---ASG-VPREELFVTTKVWNDNHG 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  92 PELVRSCLEKTLKNAQLDYVDLYIIHFPMAlqpgdklfprdehgkllaeaVDLCDTWEAMEKCKDAGLAKSIGVSNFNFR 171
Cdd:COG0656  74 YDDTLAAFEESLERLGLDYLDLYLIHWPGP--------------------GPYVETWRALEELYEEGLIRAIGVSNFDPE 133

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 172 QLETILNKPGlkYKPVCNQVECHLYLNQSQMLDYCKSKDIILVSYCTLGSSRdkiwvdqkspvLLDDPVLCAMANKYKQT 251
Cdd:COG0656 134 HLEELLAETG--VKPAVNQVELHPYLQQRELLAFCREHGIVVEAYSPLGRGK-----------LLDDPVLAEIAEKHGKT 200

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 19527294 252 PALIAIRYQLQRGIVVLTRSFKEKRIKEFMKVFEFQLASEDMKVLDGLHRNLRY 305
Cdd:COG0656 201 PAQVVLRWHLQRGVVVIPKSVTPERIRENLDAFDFELSDEDMAAIDALDRGERL 254

AKR_AKR4C1-15

cd19125

AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase ...

9-299

5.60e-96

AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase (ALR) from Hordeum vulgare (AKR4C1), Bromus inermis (AKR4C2), Avena fatua (AKR4C3), and Xerophyta viscosa (AKR4C4), two aldose reductases, DpAR1 (AKR4C5) and DpAR2(AKR4C6), from Digitalis purpurea, aldehyde reductase from Zea mays (AKR4C7), four aldo-keto reductases from Arabidopsis thaliana (AKR4C8-11), and another three aldo-keto reductases from Aloe arborescens (AKR4C12) and Oryza sativa (AKR4C14/15). ALR (EC 1.1.1.21), also called AR, aldehyde reductase, or polyol dehydrogenase (NADP(+)), is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. Both DpAR1 and DpAR2 reduce the ketone group of steroid structures. They may be involved in plant steroid metabolism in general and in cardenolide biosynthesis in particular. Plant aldo-keto reductases of the AKR4C subfamily play key roles during stress and are attractive targets for developing stress-tolerant crops.

Pssm-ID: 381351 [Multi-domain] Cd Length: 287 Bit Score: 285.78 E-value: 5.60e-96

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294   9 VLNDGHFIPALGFGT--TVPDKVpKDelikATKIAIDTGFRHFDSAYLYQIEEEVGQAIRSKIEDGTVKREDIFYTSKLW 86
Cdd:cd19125   4 KLNTGAKIPAVGLGTwqADPGVV-GN----AVKTAIKEGYRHIDCAAIYGNEKEIGKALKKLFEDGVVKREDLFITSKLW 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  87 STFHRPELVRSCLEKTLKNAQLDYVDLYIIHFPMALQPGDKLFPRDEHGKLlaeavDLCDTWEAMEKCKDAGLAKSIGVS 166
Cdd:cd19125  79 CTDHAPEDVPPALEKTLKDLQLDYLDLYLIHWPVRLKKGAHMPEPEEVLPP-----DIPSTWKAMEKLVDSGKVRAIGVS 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 167 NFNFRQLETILNKPglKYKPVCNQVECHLYLNQSQMLDYCKSKDIILVSYCTLGSSrDKIWVDQKspvLLDDPVLCAMAN 246
Cdd:cd19125 154 NFSVKKLEDLLAVA--RVPPAVNQVECHPGWQQDKLHEFCKSKGIHLSAYSPLGSP-GTTWVKKN---VLKDPIVTKVAE 227

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 19527294 247 KYKQTPALIAIRYQLQRGIVVLTRSFKEKRIKEFMKVFEFQLASEDMKVLDGL 299
Cdd:cd19125 228 KLGKTPAQVALRWGLQRGTSVLPKSTNEERIKENIDVFDWSIPEEDFAKFSSI 280

AKR_AKR4A_4B

cd19124

AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes ...

12-299

1.93e-88

AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes Glycine max NAD(P)H-dependent 6'-deoxychalcone synthase (6DCS, EC 3.1.170), chalcone reductase (CHR, EC 2.3.1.74) from Medicago sativa, Glycyrrhiza echinate, and Glycyrrhiza glabra, which are founding members of aldo-keto reductase family 4 member A1 (AKR4A1), A2 (AKR4A2), A3 (AKR4A3), and A4 (AKR4A4), respectively. NAD(P)H-6DCS co-acts with chalcone synthase in formation of 4,2',4'-trihydroxychalcone, involved in the biosynthesis of glyceollin type phytoalexins. CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. The AKR4B family of AKR includes Sesbania rostrate chalcone reductase (CHR, AKR4B1), Papaver somniferum codeinone reductase (COR, AKR4B2/ AKR4B3), Fragaria x ananassa D-galacturonate reductase (GalUR, AKR4B4), deoxymugineic acid synthase 1 (DMAS1) from Zea mays (AKR4B5), Oryza sativa (AKR4B6), Hordeum vulgare (AKR4B7), Triticum aestivum (AKR4B8), and Erythroxylum coca methylecgonone reductase (MecgoR, AKR4B10). CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. NADPH-dependent COR and non-functional NADPH-dependent COR from Papaver somniferum are founding members of aldo-keto reductase family 4 member B2 (AKR4B2) and B3 (AKR4B3), respectively. NADPH-dependent COR (EC 1.1.1.247) reduces codeinone to codeine in the penultimate step in morphine biosynthesis. It can use morphinone, hydrocodone, and hydromorphone as substrates during reductive reaction with NADPH as cofactor, and morphine and dihydrocodeine as substrates during oxidative reaction with NADP as cofactor. GalUR (EC 1.1.1.365), also called aldo-keto reductase 2 (AKR2), is involved in ascorbic acid (vitamin C) biosynthesis by catalyzing the conversion from L-galactonate and NADP(+) to D-galacturonate and NADPH. DMAS1 (EC 1.1.1.285) catalyzes the reduction of a 3''-keto intermediate during the biosynthesis of 2'-deoxymugineic acid (DMA) from L-Met. It is involved in the formation of phytosiderophores (MAs) belonging to the mugineic acid family and required to acquire iron. MecgoR catalyzes the stereospecific reduction of methylecgonone to methylecgonine, the penultimate step in cocaine biosynthesis.

Pssm-ID: 381350 [Multi-domain] Cd Length: 281 Bit Score: 266.06 E-value: 1.93e-88

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  12 DGHFIPALGFGTTVPDKVPKDelIKATKI-AIDTGFRHFDSAYLYQIEEEVGQAIRSKIEDGTVK-REDIFYTSKLWSTF 89
Cdd:cd19124   1 SGQTMPVIGMGTASDPPSPED--IKAAVLeAIEVGYRHFDTAAAYGTEEALGEALAEALRLGLVKsRDELFVTSKLWCSD 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  90 HRPELVRSCLEKTLKNAQLDYVDLYIIHFPMALQPGDKLFPRDEHgklLAEAVDLCDTWEAMEKCKDAGLAKSIGVSNFN 169
Cdd:cd19124  79 AHPDLVLPALKKSLRNLQLEYVDLYLIHWPVSLKPGKFSFPIEEE---DFLPFDIKGVWEAMEECQRLGLTKAIGVSNFS 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 170 FRQLETILNKPglKYKPVCNQVECHLYLNQSQMLDYCKSKDIILVSYCTLGSSRDKiWvdqKSPVLLDDPVLCAMANKYK 249
Cdd:cd19124 156 CKKLQELLSFA--TIPPAVNQVEMNPAWQQKKLREFCKANGIHVTAYSPLGAPGTK-W---GSNAVMESDVLKEIAAAKG 229

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 19527294 250 QTPALIAIRYQLQRGIVVLTRSFKEKRIKEFMKVFEFQLASEDMKVLDGL 299
Cdd:cd19124 230 KTVAQVSLRWVYEQGVSLVVKSFNKERMKQNLDIFDWELTEEDLEKISEI 279

AKR_AKR1G1_1I

cd19111

Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase ...

13-305

9.49e-88

Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.

Pssm-ID: 381337 [Multi-domain] Cd Length: 286 Bit Score: 264.75 E-value: 9.49e-88

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  13 GHFIPALGFGTTvpdKVPKDELIKATKIAIDTGFRHFDSAYLYQIEEEVGQAIRSKIEDGTVKREDIFYTSKLWSTFHRP 92
Cdd:cd19111   1 GFPMPVIGLGTY---QSPPEEVRAAVDYALFVGYRHIDTALSYQNEKAIGEALKWWLKNGKLKREEVFITTKLPPVYLEF 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  93 ELVRSCLEKTLKNAQLDYVDLYIIHFPMALQpgdklfPRDEHGKLLAEAVDLCDTWEAMEKCKDAGLAKSIGVSNFNFRQ 172
Cdd:cd19111  78 KDTEKSLEKSLENLKLPYVDLYLIHHPCGFV------NKKDKGERELASSDVTSVWRAMEALVSEGKVKSIGLSNFNPRQ 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 173 LETILNKPglKYKPVCNQVECHLYLNQSQMLDYCKSKDIILVSYCTLGS-SRDKIWVDQKSPVLLDDPVLCAMANKYKQT 251
Cdd:cd19111 152 INKILAYA--KVKPSNLQLECHAYLQQRELRKFCNKKNIVVTAYAPLGSpGRANQSLWPDQPDLLEDPTVLAIAKELDKT 229

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 19527294 252 PALIAIRYQLQRGIVVLTRSFKEKRIKEFMKVFEFQLASEDMKVLDGLHRNLRY 305
Cdd:cd19111 230 PAQVLLRFVLQRGTGVLPKSTNKERIEENFEVFDFELTEEHFKKLKTLDRNMKY 283

AKR_BaDH-like

cd19129

Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium ...

11-307

9.95e-88

Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium diazoefficiens DH is the prototype of this family. It belongs to aldo/keto reductase family.

Pssm-ID: 381355 [Multi-domain] Cd Length: 295 Bit Score: 265.09 E-value: 9.95e-88

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  11 NDGHFIPALGFGTTVPDKVPKDElikATKIAIDTGFRHFDSAYLYQIEEEVGQAIRSKIEDGTVKREDIFYTSKLWSTFH 90
Cdd:cd19129   1 NGSGAIPALGFGTLIPDPSATRN---AVKAALEAGFRHFDCAERYRNEAEVGEAMQEVFKAGKIRREDLFVTTKLWNTNH 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  91 RPELVRSCLEKTLKNAQLDYVDLYIIHFPMALQPGDKLFPRDEHGKLL-AEAVDLCDTWEAMEKCKDAGLAKSIGVSNFN 169
Cdd:cd19129  78 RPERVKPAFEASLKRLQLDYLDLYLIHTPFAFQPGDEQDPRDANGNVIyDDGVTLLDTWRAMERLVDEGRCKAIGLSDVS 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 170 FRQLETILNKPglKYKPVCNQVECHLYLNQSQMLDYCKSKDIILVSYCTLGSSRDkiwvdqksPVLLDDPVLCAMANKYK 249
Cdd:cd19129 158 LEKLREIFEAA--RIKPAVVQVESHPYLPEWELLDFCKNHGIVLQAFAPLGHGME--------PKLLEDPVITAIARRVN 227

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 250 QTPALIAIRYQLQRGIVVLTRSFKEKRIKEfmkVFEFQLASEDM--KVLDGLHRNLRYNT 307
Cdd:cd19129 228 KTPAQVLLAWAIQRGTALLTTSKTPSRIRE---NFDISTLPEDAmrEINEGIKTRYRFNS 284

AKR_AKR1I_CgAKR1

cd19155

Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi ...

8-304

2.88e-87

Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.

Pssm-ID: 381381 [Multi-domain] Cd Length: 307 Bit Score: 264.00 E-value: 2.88e-87

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294   8 VVLNDGHFIPALGFGTTvpdKVPKDELIKATKIAIDTGFRHFDSAYLYQIEEEVGQAIRSKIEDGTVKREDIFYTSKLWS 87
Cdd:cd19155   4 VTFNNGEKMPVVGLGTW---QSSPEEIETAVDTALEAGYRHIDTAYVYRNEAAIGNVLKKWIDSGKVKREELFIVTKLPP 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  88 TFHRPELVRSCLEKTLKNAQLDYVDLYIIHFPMALQ-PGDKLFPRDEHGK-LLAEAVDLCDTWEAMEKCKDAGLAKSIGV 165
Cdd:cd19155  81 GGNRREKVEKFLLKSLEKLQLDYVDLYLIHFPVGSLsKEDDSGKLDPTGEhKQDYTTDLLDIWKAMEAQVDQGLTRSIGL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 166 SNFNFRQLETILNKPglKYKPVCNQVECHLYLNQSQMLDYCKSKDIILVSYCTLGS-SRDKIWVDQKSPV-----LLDDP 239
Cdd:cd19155 161 SNFNREQMARILKNA--RIKPANLQVELHVYLQQKDLVDFCSTHSITVTAYAPLGSpGAAHFSPGTGSPSgsspdLLQDP 238

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19527294 240 VLCAMANKYKQTPALIAIRYQLQRGIVVLTRSFKEKRIKEFMKVFEFQLASEDMKVLDGLHRNLR 304
Cdd:cd19155 239 VVKAIAERHGKSPAQVLLRWLMQRGVVVIPKSTNAARIKENFQVFDFELTEADMAKLSSLDKNIR 303

AKR_AKR3B1-3

cd19118

AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde ...

10-299

1.79e-84

AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde reductase 1 (ARI, EC 1.1.1.2), Trichosporonoides megachilieni NADPH-dependent erthyrose reductase (ER) 1/2 and 3, are founding members of aldo-keto reductase family 3 member B1 (AKR3B1), B2 (AKR3B2), and B3 (AKR3B3), respectively. Sporidiobolus salmonicolor NADPH-ARI, also called alcohol dehydrogenase [NADP(+)], or aldehyde reductase I, or ALR 1, catalyzes the asymmetric reduction of aliphatic and aromatic aldehydes and ketones to an R-enantiomer. It reduces ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate. Trichosporonoides megachilieni NADPH-ERs catalyze the reduction of D-erythrose.

Pssm-ID: 381344 [Multi-domain] Cd Length: 283 Bit Score: 256.18 E-value: 1.79e-84

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  10 LNDGHFIPALGFGT--TVPDKVPKdelikATKIAIDTGFRHFDSAYLYQIEEEVGQAIR-SKIEDGTVKREDIFYTSKLW 86
Cdd:cd19118   1 LNTGNKIPAIGLGTwqAEPGEVGA-----AVKIALKAGYRHLDLAKVYQNQHEVGQALKeLLKEEPGVKREDLFITSKLW 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  87 STFHRPELVRSCLEKTLKNAQLDYVDLYIIHFPMALQPGDKLFPR-----DEHGKLLAEAVDLCDTWEAMEKCKDAGLAK 161
Cdd:cd19118  76 NNSHRPEYVEPALDDTLKELGLDYLDLYLIHWPVAFKPTGDLNPLtavptNGGEVDLDLSVSLVDTWKAMVELKKTGKVK 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 162 SIGVSNFNFRQLETILNKPGLkyKPVCNQVECHLYLNQSQMLDYCKSKDIILVSYCTLGSSRdkiwvdQKSPVLLDDPVL 241
Cdd:cd19118 156 SIGVSNFSIDHLQAIIEETGV--VPAVNQIEAHPLLLQDELVDYCKSKNIHITAYSPLGNNL------AGLPLLVQHPEV 227

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 19527294 242 CAMANKYKQTPALIAIRYQLQRGIVVLTRSFKEKRIKEFMKVFEfqLASEDMKVLDGL 299
Cdd:cd19118 228 KAIAAKLGKTPAQVLIAWGIQRGHSVIPKSVTPSRIRSNFEQVE--LSDDEFNAVTAL 283

AKR_AKR3A1-2

cd19117

AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are ...

10-301

3.45e-82

AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are founding members of aldo-keto reductase family 3 member A1 (AKR3A1) and A2 (AKR3A2), respectively. Gcy1p, also called galactose-inducible crystallin-like protein 1, is a glycerol dehydrogenase involved in glycerol catabolism under microaerobic conditions. It has mRNA binding activity. Ypr1p acts as a 2-methylbutyraldehyde reductase that displays high specific activity towards 2-methylbutyraldehyde, as well as other aldehydes such as hexanal.

Pssm-ID: 381343 [Multi-domain] Cd Length: 284 Bit Score: 250.49 E-value: 3.45e-82

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  10 LNDGHFIPALGFGT--TVPDKVPKdelikATKIAIDTGFRHFDSAYLYQIEEEVGQAIRskieDGTVKREDIFYTSKLWS 87
Cdd:cd19117   8 LNTGAEIPAVGLGTwqSKPNEVAK-----AVEAALKAGYRHIDTAAIYGNEEEVGQGIK----DSGVPREEIFITTKLWC 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  88 TFHRPelVRSCLEKTLKNAQLDYVDLYIIHFPMALQPG--DKLFPRDEHGKLLAEAVDLCDTWEAMEKCKDAGLAKSIGV 165
Cdd:cd19117  79 TWHRR--VEEALDQSLKKLGLDYVDLYLMHWPVPLDPDgnDFLFKKDDGTKDHEPDWDFIKTWELMQKLPATGKVKAIGV 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 166 SNFNFRQLETILNKPGLKYKPVCNQVECHLYLNQSQMLDYCKSKDIILVSYCTLGSSrdkiwvdqKSPvLLDDPVLCAMA 245
Cdd:cd19117 157 SNFSIKNLEKLLASPSAKIVPAVNQIELHPLLPQPKLVDFCKSKGIHATAYSPLGST--------NAP-LLKEPVIIKIA 227

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 19527294 246 NKYKQTPALIAIRYQLQRGIVVLTRSFKEKRIKEFMKVFEfqLASEDMKVLDGLHR 301
Cdd:cd19117 228 KKHGKTPAQVIISWGLQRGYSVLPKSVTPSRIESNFKLFT--LSDEEFKEIDELHK 281

AKR_AKR3C2-3

cd19120

Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis ...

13-297

2.20e-81

Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis NADPH-dependent conjugated polyketone reductase C2 (CPR), and similar proteins; Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase (EC 1.1.1.190/EC 1.1.1.191) and Candida parapsilosis NADPH-dependent CPR (EC 1.1.1.358/EC 1.1.1.168) are founding members of aldo-keto reductase family 3 member C2 (AKR3C2) and C3 (AKR3C3), respectively. Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase catalyzes the conversion from (Indol-3-yl)ethanol to (indol-3-yl)acetaldehyde in a NAD/NADP-dependent manner. CPR, also called 2-dehydropantolactone reductase, or 2-dehydropantolactone reductase (A-specific), or ketopantoyl-lactone reductase, acts as a NADPH-dependent conjugated polyketone reductase with broad substrate specificity and strict stereospecificity. It reduces ketopantoyl lactone and isatin.

Pssm-ID: 381346 [Multi-domain] Cd Length: 269 Bit Score: 247.92 E-value: 2.20e-81

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  13 GHFIPALGFGT-----TVPDKVPKDELIKATKIAIDTGFRHFDSAYLYQIEEEVGQAIRskiEDGtVKREDIFYTSKLws 87
Cdd:cd19120   1 GSKIPAIAFGTgtawyKSGDDDIQRDLVDSVKLALKAGFRHIDTAEMYGNEKEVGEALK---ESG-VPREDLFITTKV-- 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  88 tFHRPELVRSCLEKTLKNAQLDYVDLYIIHFPmalqpgdklFPRDEHGKLLAEAvdlcdtWEAMEKCKDAGLAKSIGVSN 167
Cdd:cd19120  75 -SPGIKDPREALRKSLAKLGVDYVDLYLIHSP---------FFAKEGGPTLAEA------WAELEALKDAGLVRSIGVSN 138

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 168 FNFRQLETILNKPglKYKPVCNQVECHLYLN--QSQMLDYCKSKDIILVSYCTLGSsrdkIWVDQKSPVlldDPVLCAMA 245
Cdd:cd19120 139 FRIEDLEELLDTA--KIKPAVNQIEFHPYLYpqQPALLEYCREHGIVVSAYSPLSP----LTRDAGGPL---DPVLEKIA 209

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 19527294 246 NKYKQTPALIAIRYQLQRGIVVLTRSFKEKRIKEFMKVFEFQLASEDMKVLD 297
Cdd:cd19120 210 EKYGVTPAQVLLRWALQKGIVVVTTSSKEERMKEYLEAFDFELTEEEVEEID 261

AKR_AKR2A1-2

cd19112

AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 ...

6-311

7.01e-81

AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 (NADP-dependent D-sorbitol-6-phosphate dehydrogenase or NADP-S6PDH) from Malus domestica, and AKR2A2 (NADPH-dependent mannose-6-phosphate reductase or NADPH-M6PR) from Apium graveolens. NADP-S6PDH (EC 1.1.1.200), also called aldose-6-phosphate reductase [NADPH], synthesizes sorbitol-6-phosphate, a key intermediate in the synthesis of sorbitol which is a major photosynthetic product in many members of the Rosaceae family. NADPH-M6PR (EC 1.1.1.224), also called NADPH-dependent M6P reductase, is a key enzyme involved in mannitol biosynthesis.

Pssm-ID: 381338 [Multi-domain] Cd Length: 308 Bit Score: 247.78 E-value: 7.01e-81

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294   6 PRVVLNDGHFIPALGFGTTVPDK-VPKDELIKATKIaidtGFRHFDSAYLYQIEEEVGQAIRSKIEDGTVKREDIFYTSK 84
Cdd:cd19112   1 STITLNSGHKMPVIGLGVWRMEPgEIKELILNAIKI----GYRHFDCAADYKNEKEVGEALAEAFKTGLVKREDLFITTK 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  85 LWSTFHrpELVRSCLEKTLKNAQLDYVDLYIIHFPMALQ------PGDKLfprDEHGKLLAEA-VDLCDTWEAMEKCKDA 157
Cdd:cd19112  77 LWNSDH--GHVIEACKDSLKKLQLDYLDLYLVHFPVATKhtgvgtTGSAL---GEDGVLDIDVtISLETTWHAMEKLVSA 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 158 GLAKSIGVSNFNFRQLETILNKPglKYKPVCNQVECHLYLNQSQMLDYCKSKDIILVSYCTLG-SSRDKIWVDQKSPvlL 236
Cdd:cd19112 152 GLVRSIGISNYDIFLTRDCLAYS--KIKPAVNQIETHPYFQRDSLVKFCQKHGISVTAHTPLGgAAANAEWFGSVSP--L 227

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19527294 237 DDPVLCAMANKYKQTPALIAIRYQLQRGIVVLTRSFKEKRIKEFMKVFEFQLASEDMKVLDGLHRNLRYNTASYF 311
Cdd:cd19112 228 DDPVLKDLAKKYGKSAAQIVLRWGIQRNTAVIPKSSKPERLKENIDVFDFQLSKEDMKLIKSLDRKYRTNQPAKF 302

AKR_AKR2B1-10

cd19113

AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent ...

6-306

1.19e-79

AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent D-xylose reductase (XR) from Pichia stipites, Kluyveromyces lactis, Pachysolen tannophilus, Candida tropicalis, and Candida tenuis, Gre3p from Saccharomyces cerevisiae, XR from Candida tropicalis, Pichia guilliermondii, Debaryomyces hansenli, and Debaryomyces nepalensis, which correspond to aldo-keto reductase family 2 member B1-B10 (AKR2B1-10), respectively. XR (EC1.1.1.307) catalyzes the NAD(P)H dependent reduction of xylose to xylitol.

Pssm-ID: 381339 [Multi-domain] Cd Length: 310 Bit Score: 244.66 E-value: 1.19e-79

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294   6 PRVVLNDGHFIPALGFGTTvpdKVPKDELIKATKIAIDTGFRHFDSAYLYQIEEEVGQAIRSKIEDGTVKREDIFYTSKL 85
Cdd:cd19113   1 PDIKLNSGYKMPSVGFGCW---KLDNATAADQIYQAIKAGYRLFDGAEDYGNEKEVGEGVNRAIDEGLVKREELFLTSKL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  86 WSTFHRPELVRSCLEKTLKNAQLDYVDLYIIHFPMALQ--PGDKLFPRD----EHGKLLAEAVDLCDTWEAMEKCKDAGL 159
Cdd:cd19113  78 WNNFHDPKNVETALNKTLSDLKLDYVDLFLIHFPIAFKfvPIEEKYPPGfycgDGDNFVYEDVPILDTWKALEKLVDAGK 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 160 AKSIGVSNFNFRQLETILNkpGLKYKPVCNQVECHLYLNQSQMLDYCKSKDIILVSYCTLGsSRDKIWVDQK----SPVL 235
Cdd:cd19113 158 IKSIGVSNFPGALILDLLR--GATIKPAVLQIEHHPYLQQPKLIEYAQKAGITITAYSSFG-PQSFVELNQGralnTPTL 234

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19527294 236 LDDPVLCAMANKYKQTPALIAIRYQLQRGIVVLTRSFKEKRIKEFMKVFEFQLASEDMKVLDGLHRNLRYN 306
Cdd:cd19113 235 FEHDTIKSIAAKHNKTPAQVLLRWATQRGIAVIPKSNLPERLLQNLSVNDFDLTKEDFEEIAKLDIGLRFN 305

AKR_AKR3D1

cd19121

AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, ...

10-299

4.28e-79

AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, EC 1.1.1.365), also called D-galacturonic acid reductase, or GalUR, is a founding member of aldo-keto reductase family 3 member D1 (AKR3D1). It mediates the reduction of D-galacturonate to L-galactonate, the first step in D-galacturonate catabolic process. It also has activity with D-glucuronate and DL-glyceraldehyde. Its activity is seen only with NADPH and not with NADH.

Pssm-ID: 381347 [Multi-domain] Cd Length: 279 Bit Score: 242.44 E-value: 4.28e-79

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  10 LNDGHFIPALGFGTTVPDKvpkDELIKATKIAIDTGFRHFDSAYLYQIEEEVGQAIRSKIeDGTVKREDIFYTSKLWSTF 89
Cdd:cd19121   6 LNTGASIPAVGLGTWQAKA---GEVKAAVAHALKIGYRHIDGALCYQNEDEVGEGIKEAI-AGGVKREDLFVTTKLWSTY 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  90 H-RPELvrsCLEKTLKNAQLDYVDLYIIHFPMALQP--GDKLFPRDEHGKL-LAEAVDLCDTWEAMEKCKDAGLAKSIGV 165
Cdd:cd19121  82 HrRVEL---CLDRSLKSLGLDYVDLYLVHWPVLLNPngNHDLFPTLPDGSRdLDWDWNHVDTWKQMEKVLKTGKTKAIGV 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 166 SNFNFRQLETILnkPGLKYKPVCNQVECHLYLNQSQMLDYCKSKDIILVSYCTLGSSrdkiwvdqKSPVLLDDPVLcAMA 245
Cdd:cd19121 159 SNYSIPYLEELL--KHATVVPAVNQVENHPYLPQQELVDFCKEKGILIEAYSPLGST--------GSPLISDEPVV-EIA 227

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 19527294 246 NKYKQTPALIAIRYQLQRGIVVLTRSFKEKRIKEFMKVFEFQlaSEDMKVLDGL 299
Cdd:cd19121 228 KKHNVGPGTVLISYQVARGAVVLPKSVTPDRIKSNLEIIDLD--DEDMNKLNDI 279

AKR_AKR3F2_3

cd19073

Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti ...

16-297

1.90e-78

Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti isatin reductase and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.

Pssm-ID: 381299 [Multi-domain] Cd Length: 243 Bit Score: 239.48 E-value: 1.90e-78

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  16 IPALGFGTTvpdKVPKDELIKATKIAIDTGFRHFDSAYLYQIEEEVGQAIRskieDGTVKREDIFYTSKLWSTFHRPELV 95
Cdd:cd19073   1 IPALGLGTW---QLRGDDCANAVKEALELGYRHIDTAEIYNNEAEVGEAIA----ESGVPREDLFITTKVWRDHLRPEDL 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  96 RSCLEKTLKNAQLDYVDLYIIHFPmalqpgdklfprdehgkllAEAVDLCDTWEAMEKCKDAGLAKSIGVSNFNFRQLET 175
Cdd:cd19073  74 KKSVDRSLEKLGTDYVDLLLIHWP-------------------NPTVPLEETLGALKELKEAGKVKSIGVSNFTIELLEE 134

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 176 ILNKPGLKykPVCNQVECHLYLNQSQMLDYCKSKDIILVSYCTLGSSRdkiwvdqkspvLLDDPVLCAMANKYKQTPALI 255
Cdd:cd19073 135 ALDISPLP--IAVNQVEFHPFLYQAELLEYCRENDIVITAYSPLARGE-----------VLRDPVIQEIAEKYDKTPAQV 201

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 19527294 256 AIRYQLQRGIVVLTRSFKEKRIKEFMKVFEFQLASEDMKVLD 297
Cdd:cd19073 202 ALRWLVQKGIVVIPKASSEDHLKENLAIFDWELTSEDVAKID 243

AKR_GlAR-like

cd19128

Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), ...

17-299

2.17e-78

Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), also called aldehyde reductase, is the prototype of this family. It catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.

Pssm-ID: 381354 [Multi-domain] Cd Length: 277 Bit Score: 240.50 E-value: 2.17e-78

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  17 PALGFGTTvpdKVPKDELIKATKIAIDTGFRHFDSAYLYQIEEEVGQAIRSKIEDGTVKREDIFYTSKLWSTFHRPELVR 96
Cdd:cd19128   2 PRLGFGTY---KITESESKEAVKNAIKAGYRHIDCAYYYGNEAFIGIAFSEIFKDGGVKREDLFITSKLWPTMHQPENVK 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  97 SCLEKTLKNAQLDYVDLYIIHFPMALQPGDKLFPRDEHGKLLAEAVDLCDTWEAMEKCKDAGLAKSIGVSNFNFRQLETI 176
Cdd:cd19128  79 EQLLITLQDLQLEYLDLFLIHWPLAFDMDTDGDPRDDNQIQSLSKKPLEDTWRAMEQCVDEKLTKNIGVSNYSTKLLTDL 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 177 LNKpgLKYKPVCNQVECHLYLNQSQMLDYCKSKDIILVSYCTLGSSRdkiwvDQKSPVLLDDPVLCAMANKYKQTPALIA 256
Cdd:cd19128 159 LNY--CKIKPFMNQIECHPYFQNDKLIKFCIENNIHVTAYRPLGGSY-----GDGNLTFLNDSELKALATKYNTTPPQVI 231

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 19527294 257 IRYQLQR---GIVVLTRSFKEKRIKEFMKVFEFQLASEDMKVLDGL 299
Cdd:cd19128 232 IAWHLQKwpkNYSVIPKSANKSRCQQNFDINDLALTKEDMDAINTL 277

AKR_AKR2D1

cd19115

AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose ...

5-306

2.82e-77

AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose reductase xyl1 (XR, EC 1.1.1.307) is a founding member of aldo-keto reductase family 2 member D1 (AKR2D1). It catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol in a NAD(P)H dependent manner.

Pssm-ID: 381341 [Multi-domain] Cd Length: 311 Bit Score: 238.86 E-value: 2.82e-77

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294   5 SPRVVLNDGHFIPALGFGTTvpdKVPKDELIKATKIAIDTGFRHFDSAYLYQIEEEVGQAIRSKIEDGTVKREDIFYTSK 84
Cdd:cd19115   2 SPTVKLNSGYDMPLVGFGLW---KVNNDTCADQVYNAIKAGYRLFDGACDYGNEVEAGQGVARAIKEGIVKREDLFIVSK 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  85 LWSTFHRPELVRSCLEKTLKNAQLDYVDLYIIHFPMALQ---PGDKLFP--RDEHGKLLAEAVDLCDTWEAMEKCKDAGL 159
Cdd:cd19115  79 LWNTFHDGERVEPICRKQLADWGIDYFDLFLIHFPIALKyvdPAVRYPPgwFYDGKKVEFSNAPIQETWTAMEKLVDKGL 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 160 AKSIGVSNFNFRQLETILNKPglKYKPVCNQVECHLYLNQSQMLDYCKSKDIILVSYCTLG-SSRDKIWVDQ--KSPVLL 236
Cdd:cd19115 159 ARSIGVSNFSAQLLMDLLRYA--RIRPATLQIEHHPYLTQPRLVKYAQKEGIAVTAYSSFGpQSFLELDLPGakDTPPLF 236

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 237 DDPVLCAMANKYKQTPALIAIRYQLQRGIVVLTRSFKEKRIKEFMKVFEFQLASEDMKVLDGLHRNLRYN 306
Cdd:cd19115 237 EHDVIKSIAEKHGKTPAQVLLRWATQRGIAVIPKSNNPKRLAQNLDVTGFDLEAEEIKAISALDIGLRFN 306

AKR_AKR5C2

cd19131

Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; ...

8-299

8.62e-77

Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; Escherichia coli DkgA/YqhE is a founding member of aldo-keto reductase family 5 member C2 (AKR5C2). DkgA/YqhE (EC 1.1.1.274), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives.

Pssm-ID: 381357 [Multi-domain] Cd Length: 256 Bit Score: 235.73 E-value: 8.62e-77

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294   8 VVLNDGHFIPALGFGTTvpdKVPKDELIKATKIAIDTGFRHFDSAYLYQIEEEVGQAIRskieDGTVKREDIFYTSKLWS 87
Cdd:cd19131   2 ITLNDGNTIPQLGLGVW---QVSNDEAASAVREALEVGYRSIDTAAIYGNEEGVGKAIR----ASGVPREELFITTKLWN 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  88 TFHRPELVRSCLEKTLKNAQLDYVDLYIIHFPMALQpgdklfprdehGKLLaeavdlcDTWEAMEKCKDAGLAKSIGVSN 167
Cdd:cd19131  75 SDQGYDSTLRAFDESLRKLGLDYVDLYLIHWPVPAQ-----------DKYV-------ETWKALIELKKEGRVKSIGVSN 136

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 168 FNFRQLETILNKPGLKykPVCNQVECHLYLNQSQMLDYCKSKDIILVSYCTLGSSRdkiwvdqkspvLLDDPVLCAMANK 247
Cdd:cd19131 137 FTIEHLQRLIDETGVV--PVVNQIELHPRFQQRELRAFHAKHGIQTESWSPLGQGG-----------LLSDPVIGEIAEK 203

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 19527294 248 YKQTPALIAIRYQLQRGIVVLTRSFKEKRIKEFMKVFEFQLASEDMKVLDGL 299
Cdd:cd19131 204 HGKTPAQVVIRWHLQNGLVVIPKSVTPSRIAENFDVFDFELDADDMQAIAGL 255

AKR_DrGR-like

cd19136

Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like ...

16-299

4.82e-76

Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like protein is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase similar to Bacillus subtilis glyoxal reductase (YvgN) that reduces glyoxal and methylglyoxal (2-oxopropanal).

Pssm-ID: 381362 [Multi-domain] Cd Length: 262 Bit Score: 234.06 E-value: 4.82e-76

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  16 IPALGFGTTvpdKVPK-DELIKATKIAIDTGFRHFDSAYLYQIEEEVGQAIRSKIEDGTVKREDIFYTSKLWSTFHRPEL 94
Cdd:cd19136   1 MPILGLGTF---RLRGeEEVRQAVDAALKAGYRLIDTASVYRNEADIGKALRDLLPKYGLSREDIFITSKLAPKDQGYEK 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  95 VRSCLEKTLKNAQLDYVDLYIIHFPMA--LQPGDklfprDEHGKLLAEavdlcdTWEAMEKCKDAGLAKSIGVSNFNFRQ 172
Cdd:cd19136  78 ARAACLGSLERLGTDYLDLYLIHWPGVqgLKPSD-----PRNAELRRE------SWRALEDLYKEGKLRAIGVSNYTVRH 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 173 LETILNKPglKYKPVCNQVECHLYLNQSQMLDYCKSKDIILVSYCTLGSSrdkiwvdqkSPVLLDDPVLCAMANKYKQTP 252
Cdd:cd19136 147 LEELLKYC--EVPPAVNQVEFHPHLVQKELLKFCKDHGIHLQAYSSLGSG---------DLRLLEDPTVLAIAKKYGRTP 215

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 19527294 253 ALIAIRYQLQRGIVVLTRSFKEKRIKEFMKVFEFQLASEDMKVLDGL 299
Cdd:cd19136 216 AQVLLRWALQQGIGVIPKSTNPERIAENIKVFDFELSEEDMAELNAL 262

AKR_AKR5A_5G

cd19126

AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes ...

8-299

1.02e-72

AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes prostaglandin F2-alpha synthase (PGFS) from Leishmania major (AKR5A1) and Trypanosoma brucei (AKR5A2). PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity for synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde. The AKR5G family of AKR includes Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase, which corresponds to aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.

Pssm-ID: 381352 [Multi-domain] Cd Length: 254 Bit Score: 225.01 E-value: 1.02e-72

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294   8 VVLNDGHFIPALGFGT-TVPDKvpkDELIKATKIAIDTGFRHFDSAYLYQIEEEVGQAIRSkiedGTVKREDIFYTSKLW 86
Cdd:cd19126   1 VTLNNGTRMPWLGLGVfQTPDG---DETERAVQTALENGYRSIDTAAIYKNEEGVGEAIRE----SGVPREELFVTTKLW 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  87 STFHRPELVRSCLEKTLKNAQLDYVDLYIIHFPMAlqpgDKLFprdehgkllaeavdlcDTWEAMEKCKDAGLAKSIGVS 166
Cdd:cd19126  74 NDDQRARRTEDAFQESLDRLGLDYVDLYLIHWPGK----DKFI----------------DTWKALEKLYASGKVKAIGVS 133

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 167 NFNFRQLETILNKPglKYKPVCNQVECHLYLNQSQMLDYCKSKDIILVSYCTLGSSRdkiwvdqkspvLLDDPVLCAMAN 246
Cdd:cd19126 134 NFQEHHLEELLAHA--DVVPAVNQVEFHPYLTQKELRGYCKSKGIVVEAWSPLGQGG-----------LLSNPVLAAIGE 200

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 19527294 247 KYKQTPALIAIRYQLQRGIVVLTRSFKEKRIKEFMKVFEFQLASEDMKVLDGL 299
Cdd:cd19126 201 KYGKSAAQVVLRWDIQHGVVTIPKSVHASRIKENADIFDFELSEDDMTAIDAL 253

AKR_AKR5G1-3

cd19157

AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), ...

8-305

1.60e-72

AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase are founding members of aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.

Pssm-ID: 381383 [Multi-domain] Cd Length: 265 Bit Score: 224.96 E-value: 1.60e-72

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294   8 VVLNDGHFIPALGFGTTvpdKVPKD-ELIKATKIAIDTGFRHFDSAYLYQIEEEVGQAIRskieDGTVKREDIFYTSKLW 86
Cdd:cd19157   2 VTLNNGVKMPWLGLGVF---KVEEGsEVVNAVKTALKNGYRSIDTAAIYGNEEGVGKGIK----ESGIPREELFITSKVW 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  87 STFHRPELVRSCLEKTLKNAQLDYVDLYIIHFPmalqpGDKLFPrdehgkllaeavdlcDTWEAMEKCKDAGLAKSIGVS 166
Cdd:cd19157  75 NADQGYDSTLKAFEASLERLGLDYLDLYLIHWP-----VKGKYK---------------ETWKALEKLYKDGRVRAIGVS 134

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 167 NFNFRQLETILNKPglKYKPVCNQVECHLYLNQSQMLDYCKSKDIilvsyctlgssrdkiWVDQKSPV----LLDDPVLC 242
Cdd:cd19157 135 NFQVHHLEDLLADA--EIVPMVNQVEFHPRLTQKELRDYCKKQGI---------------QLEAWSPLmqgqLLDNPVLK 197

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19527294 243 AMANKYKQTPALIAIRYQLQRGIVVLTRSFKEKRIKEFMKVFEFQLASEDMKVLDGLHRNLRY 305
Cdd:cd19157 198 EIAEKYNKSVAQVILRWDLQNGVVTIPKSIKEHRIIENADVFDFELSQEDMDKIDALNENLRV 260

AKR_AKR5D1_E1

cd19132

AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B ...

10-301

3.12e-72

AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B (DkgB) from Corynebacterium sp. and 2,5-diketo-D-gluconic acid reductase Zymomonas mobilis are founding members of aldo-keto reductase family 5 member D1 (AKR5D1) and E1 (AKR5E1), respectively. DkgB (EC 1.1.1.274), also called 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).

Pssm-ID: 381358 [Multi-domain] Cd Length: 255 Bit Score: 224.07 E-value: 3.12e-72

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  10 LNDGHFIPALGFGTTvpdKVPKDELIKATKIAIDTGFRHFDSAYLYQIEEEVGQAIRSkiedGTVKREDIFYTSKLWSTF 89
Cdd:cd19132   1 LNDGTQIPAIGFGTY---PLKGDEGVEAVVAALQAGYRLLDTAFNYENEGAVGEAVRR----SGVPREELFVTTKLPGRH 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  90 HRPELVRSCLEKTLKNAQLDYVDLYIIHFPMalqpgdklfPRdehgkllaeaVDL-CDTWEAMEKCKDAGLAKSIGVSNF 168
Cdd:cd19132  74 HGYEEALRTIEESLYRLGLDYVDLYLIHWPN---------PS----------RDLyVEAWQALIEAREEGLVRSIGVSNF 134

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 169 NFRQLETILNKPGLKykPVCNQVECHLYLNQSQMLDYCKSKDIILVSYCTLGSSRDkiwvdqkspvLLDDPVLCAMANKY 248
Cdd:cd19132 135 LPEHLDRLIDETGVT--PAVNQIELHPYFPQAEQRAYHREHGIVTQSWSPLGRGSG----------LLDEPVIKAIAEKH 202

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 19527294 249 KQTPALIAIRYQLQRGIVVLTRSFKEKRIKEFMKVFEFQLASEDMKVLDGLHR 301
Cdd:cd19132 203 GKTPAQVVLRWHVQLGVVPIPKSANPERQRENLAIFDFELSDEDMAAIAALDR 255

AKR_AKR3C1

cd19119

Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar ...

10-301

6.13e-72

Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar proteins; Saccharomyces cerevisiae Ara1p (EC 1.1.1.117), also called D-arabinose 1-dehydrogenase (NAD(P)(+)), is a founding members of aldo-keto reductase family 3 member C1 (AKR3C1). It catalyzes the oxidation of D-arabinose, L-xylose, L-fucose, and L-galactose in the presence of NADP(+).

Pssm-ID: 381345 [Multi-domain] Cd Length: 294 Bit Score: 224.68 E-value: 6.13e-72

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  10 LNDGHFIPALGFGTTVPDKvPKDELIKATKIAIDTGFRHFDSAYLYQIEEEVGQAIRSKIEDGTVKREDIFYTSKLWSTF 89
Cdd:cd19119   6 LNTGASIPALGLGTASPHE-DRAEVKEAVEAAIKEGYRHIDTAYAYETEDFVGEAIKRAIDDGSIKREELFITTKVWPTF 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  90 HRPelVRSCLEKTLKNAQLDYVDLYIIHFPMALQ-----PGDKLFPRDEHGKLL-AEAVDLCDTWEAMEKCKDAGLAKSI 163
Cdd:cd19119  85 YDE--VERSLDESLKALGLDYVDLLLVHWPVCFEkdsddSGKPFTPVNDDGKTRyAASGDHITTYKQLEKIYLDGRAKAI 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 164 GVSNFNFRQLETILNKpgLKYKPVCNQVECHLYLNQSQMLDYCKSKDIILVSYCTLGSSRDKIwvdqkspvlLDDPVLCA 243
Cdd:cd19119 163 GVSNYSIVYLERLIKE--CKVVPAVNQVELHPHLPQMDLRDFCFKHGILVTAYSPLGSHGAPN---------LKNPLVKK 231

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 19527294 244 MANKYKQTPALIAIRYQLQRGIVVLTRSFKEKRIKEFMKVfeFQLASEDMKVLDGLHR 301
Cdd:cd19119 232 IAEKYNVSTGDILISYHVRQGVIVLPKSLKPVRIVSNGKI--VSLTKEDLQKLDDIGE 287

AKR_AKR5F1

cd19133

the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid ...

8-299

1.07e-69

the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid reductase (2,5-DKG reductase) is a founding member of aldo-keto reductase family 5 member F1 (AKR5F1). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).

Pssm-ID: 381359 [Multi-domain] Cd Length: 255 Bit Score: 217.44 E-value: 1.07e-69

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294   8 VVLNDGHFIPALGFGT-TVPDKvpkDELIKATKIAIDTGFRHFDSAYLYQIEEEVGQAIRskieDGTVKREDIFYTSKLW 86
Cdd:cd19133   1 VTLNNGVEMPILGFGVfQIPDP---EECERAVLEAIKAGYRLIDTAAAYGNEEAVGRAIK----KSGIPREELFITTKLW 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  87 STFHRPELVRSCLEKTLKNAQLDYVDLYIIHFPMAlqpgdklfprDEHGkllaeavdlcdTWEAMEKCKDAGLAKSIGVS 166
Cdd:cd19133  74 IQDAGYEKAKKAFERSLKRLGLDYLDLYLIHQPFG----------DVYG-----------AWRAMEELYKEGKIRAIGVS 132

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 167 NFNFRQLETILnkPGLKYKPVCNQVECHLYLNQSQMLDYCKSKDIILVSYCTLGSSRDKIwvdqkspvlLDDPVLCAMAN 246
Cdd:cd19133 133 NFYPDRLVDLI--LHNEVKPAVNQIETHPFNQQIEAVEFLKKYGVQIEAWGPFAEGRNNL---------FENPVLTEIAE 201

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 19527294 247 KYKQTPALIAIRYQLQRGIVVLTRSFKEKRIKEFMKVFEFQLASEDMKVLDGL 299
Cdd:cd19133 202 KYGKSVAQVILRWLIQRGIVVIPKSVRPERIAENFDIFDFELSDEDMEAIAAL 254

AKR_CeZK1290-like

cd19135

Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the ...

6-300

1.92e-69

Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.

Pssm-ID: 381361 [Multi-domain] Cd Length: 265 Bit Score: 217.19 E-value: 1.92e-69

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294   6 PRVVLNDGHFIPALGFGTTVPDKVPKDELIKATKiaiDTGFRHFDSAYLYQIEEEVGQAIRskiEDGtVKREDIFYTSKL 85
Cdd:cd19135   3 PTVRLSNGVEMPILGLGTSHSGGYSHEAVVYALK---ECGYRHIDTAKRYGCEELLGKAIK---ESG-VPREDLFLTTKL 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  86 WSTFHRPELVRSCLEKTLKNAQLDYVDLYIIHFPMALQPGDKlfPRDehgkLLAEavdlcdTWEAMEKCKDAGLAKSIGV 165
Cdd:cd19135  76 WPSDYGYESTKQAFEASLKRLGVDYLDLYLLHWPDCPSSGKN--VKE----TRAE------TWRALEELYDEGLCRAIGV 143

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 166 SNFNFRQLETILNKPGLKykPVCNQVECHLYLNQSQMLDYCKSKDIILVSYCTLGSSRdkiwvdqkspvLLDDPVLCAMA 245
Cdd:cd19135 144 SNFLIEHLEQLLEDCSVV--PHVNQVEFHPFQNPVELIEYCRDNNIVFEGYCPLAKGK-----------ALEEPTVTELA 210

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 19527294 246 NKYKQTPALIAIRYQLQRGIVVLTRSFKEKRIKEFMKVFEFQLASEDMKVLDGLH 300
Cdd:cd19135 211 KKYQKTPAQILIRWSIQNGVVTIPKSTKEERIKENCQVFDFSLSEEDMATLDSLH 265

AKR_AKR2C1

cd19114

AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent ...

13-306

2.39e-69

AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent 4-dihydromethyl-trisporate dehydrogenase (TDH), also called 4-dihydromethyltrisporate dehydrogenase, or 4-dihydromethyl-TA dehydrogenase, is a founding member of aldo-keto reductase family 2 member C1 (AKR2C1). It is involved in the biosynthesis of trisporic acid, the sexual hormone of zygomycetes, which induces the first steps of zygophore development. TDH catalyzes the NADP-dependent oxidation of (+) mating-type specific precursor 4-dihydromethyl-trisporate to methyl-trisporate.

Pssm-ID: 381340 [Multi-domain] Cd Length: 302 Bit Score: 218.20 E-value: 2.39e-69

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  13 GHFIPALGFGTTvpdKVPKDELIKATKIAIDTGFRHFDSAYLYQIEEEVGQAIRSKIEDGTVKREDIFYTSKLWSTFHRP 92
Cdd:cd19114   1 GDKMPLVGFGTA---KIKANETEEVIYNAIKVGYRLIDGALLYGNEAEVGRGIRKAIQEGLVKREDLFIVTKLWNNFHGK 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  93 ELVRSCLEKTLKNAQLDYVDLYIIHFPMALQ---PGDKLFPRDEHGKLLA---EAVDLCDTWEAMEKCKDAGLAKSIGVS 166
Cdd:cd19114  78 DHVREAFDRQLKDYGLDYIDLYLIHFPIPAAyvdPAENYPFLWKDKELKKfplEQSPMQECWREMEKLVDAGLVRNIGIA 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 167 NFNFRQLETILNKPglKYKPVCNQVECHLYLNQSQMLDYCKSKDIILVSYCTLGS-SRDKIWVDQKS-PVLLDDPVLCAM 244
Cdd:cd19114 158 NFNVQLILDLLTYA--KIKPAVLQIEHHPYLQQKRLIDWAKKQGIQITAYSSFGNaVYTKVTKHLKHfTNLLEHPVVKKL 235

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19527294 245 ANKYKQTPALIAIRYQLQRGIVVLTRSFKEKRIKEFMKVFEFQLASEDMKVLDGLHRNLRYN 306
Cdd:cd19114 236 ADKHKRDTGQVLLRWAVQRNITVIPKSVNVERMKTNLDITSYKLDEEDMEALYELEANARFN 297

AKR_AKR3F3

cd19140

Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin ...

13-299

1.16e-67

Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.

Pssm-ID: 381366 [Multi-domain] Cd Length: 253 Bit Score: 212.12 E-value: 1.16e-67

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  13 GHFIPALGFGTTvpdKVPKDELIKATKIAIDTGFRHFDSAYLYQIEEEVGQAIRskieDGTVKREDIFYTSKLWSTFHRP 92
Cdd:cd19140   5 GVRIPALGLGTY---PLTGEECTRAVEHALELGYRHIDTAQMYGNEAQVGEAIA----ASGVPRDELFLTTKVWPDNYSP 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  93 ELVRSCLEKTLKNAQLDYVDLYIIHFPmalqpgdklfPRDehgkllaeaVDLCDTWEAMEKCKDAGLAKSIGVSNFNFRQ 172
Cdd:cd19140  78 DDFLASVEESLRKLRTDYVDLLLLHWP----------NKD---------VPLAETLGALNEAQEAGLARHIGVSNFTVAL 138

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 173 LETILNKPGLKYkpVCNQVECHLYLNQSQMLDYCKSKDIILVSYCTLGSSRdkiwvdqkspvLLDDPVLCAMANKYKQTP 252
Cdd:cd19140 139 LREAVELSEAPL--FTNQVEYHPYLDQRKLLDAAREHGIALTAYSPLARGE-----------VLKDPVLQEIGRKHGKTP 205

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 19527294 253 ALIAIRYQLQR-GIVVLTRSFKEKRIKEFMKVFEFQLASEDMKVLDGL 299
Cdd:cd19140 206 AQVALRWLLQQeGVAAIPKATNPERLEENLDIFDFTLSDEEMARIAAL 253

AKR_AKR5A1_2

cd19156

AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from ...

8-305

5.29e-67

AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from Leishmania major and Trypanosoma brucei are founding members of aldo-keto reductase family 5 member A1 (AKR5A1) and A2 (AKR5A2), respectively. PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.

Pssm-ID: 381382 [Multi-domain] Cd Length: 266 Bit Score: 210.84 E-value: 5.29e-67

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294   8 VVLNDGHFIPALGFGT-TVPDKvpkDELIKATKIAIDTGFRHFDSAYLYQIEEEVGQAIRSKiedgTVKREDIFYTSKLW 86
Cdd:cd19156   1 VKLANGVEMPRLGLGVwRVQDG---AEAENAVKWAIEAGYRHIDTAAIYKNEEGVGQGIRES----GVPREEVFVTTKLW 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  87 STFHRPELVRSCLEKTLKNAQLDYVDLYIIHFPMAlqpgdklfprdehGKLLaeavdlcDTWEAMEKCKDAGLAKSIGVS 166
Cdd:cd19156  74 NSDQGYESTLAAFEESLEKLGLDYVDLYLIHWPVK-------------GKFK-------DTWKAFEKLYKEKKVRAIGVS 133

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 167 NFNFRQLETILNKpgLKYKPVCNQVECHLYLNQSQMLDYCKSKDIILVSYCTLGSSRdkiwvdqkspvLLDDPVLCAMAN 246
Cdd:cd19156 134 NFHEHHLEELLKS--CKVAPMVNQIELHPLLTQEPLRKFCKEKNIAVEAWSPLGQGK-----------LLSNPVLKAIGK 200

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 19527294 247 KYKQTPALIAIRYQLQRGIVVLTRSFKEKRIKEFMKVFEFQLASEDMKVLDGLHRNLRY 305
Cdd:cd19156 201 KYGKSAAQVIIRWDIQHGIITIPKSVHEERIQENFDVFDFELTAEEIRQIDGLNTDHRY 259

AKR_AKR3E1

cd19122

AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol ...

10-297

1.08e-62

AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol 2-dehydrogenase (GLD2, EC 1.1.1.156), also called dihydroxyacetone reductase, is a founding member of aldo-keto reductase family 3 member E1 (AKR3E1). It acts as a glycerol oxidoreductase probably involved in glycerol synthesis.

Pssm-ID: 381348 [Multi-domain] Cd Length: 291 Bit Score: 200.93 E-value: 1.08e-62

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  10 LNDGHFIPALGFGTTVPDKVpKDELIKATKIAIDTGFRHFDSAYLYQIEEEVGQAIRSKI-EDGTVKREDIFYTSKLWST 88
Cdd:cd19122   3 LNNGVKIPAVGFGTFANEGA-KGETYAAVTKALDVGYRHLDCAWFYLNEDEVGDAVRDFLkENPSVKREDLFICTKVWNH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  89 FHRPELVRSCLEKTLKNAQLDYVDLYIIHFPMALQPGDKLFPR-DEHGKLLAEAvDLCD----TWEAMEKCKDAGLAKSI 163
Cdd:cd19122  82 LHEPEDVKWSIDNSLKNLKLDYIDLFLVHWPIAAEKNDQRSPKlGPDGKYVILK-DLTEnpepTWRAMEEIYESGKAKAI 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 164 GVSNFNFRQLETILNKPglKYKPVCNQVECHLYLNQSQMLDYCKSKDIILVSYCTLGSSRDkiwVDQKSPVLLDDPVLCA 243
Cdd:cd19122 161 GVSNWTIPGLKKLLSFA--KVKPHVNQIEIHPFLPNEELVDYCFSNDILPEAYSPLGSQNQ---VPSTGERVSENPTLNE 235

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 19527294 244 MANKYKQTPALIAIRYQLQRGIVVLTRSFKEKRIKEFMKVFEfqLASEDMKVLD 297
Cdd:cd19122 236 VAEKGGYSLAQVLIAWGLRRGYVVLPKSSTPSRIESNFKSIE--LSDEDFEAIN 287

AKR_AKR5H1

cd19134

AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding ...

6-305

3.62e-61

AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding member of aldo-keto reductase family 5 member H1 (AKR5H1). It is a NADPH-dependent aldo-keto reductase that reduces methylglyoxal and phenylglyoxal.

Pssm-ID: 381360 [Multi-domain] Cd Length: 263 Bit Score: 195.84 E-value: 3.62e-61

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294   6 PRVVLNDGHFIPALGFGTTvpdKVPKDELIKATKIAIDTGFRHFDSAYLYQIEEEVGQAIRSKiedgTVKREDIFYTSKL 85
Cdd:cd19134   1 PTVTLNDDNTMPVIGLGVG---ELSDDEAERSVSAALEAGYRLIDTAAAYGNEAAVGRAIAAS----GIPRGELFVTTKL 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  86 WSTFHRPELVRSCLEKTLKNAQLDYVDLYIIHFPMALQpgdklfprdehGKLLaeavdlcDTWEAMEKCKDAGLAKSIGV 165
Cdd:cd19134  74 ATPDQGFTASQAACRASLERLGLDYVDLYLIHWPAGRE-----------GKYV-------DSWGGLMKLREEGLARSIGV 135

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 166 SNFNFRQLETILNKPGlkYKPVCNQVECHLYLNQSQMLDYCKSKDIILVSYCTLGSSRdkiwvdqkspvLLDDPVLCAMA 245
Cdd:cd19134 136 SNFTAEHLENLIDLTF--FTPAVNQIELHPLLNQAELRKVNAQHGIVTQAYSPLGVGR-----------LLDNPAVTAIA 202

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 246 NKYKQTPALIAIRYQLQRGIVVLTRSFKEKRIKEFMKVFEFQLASEDMKVLDGLHRNLRY 305
Cdd:cd19134 203 AAHGRTPAQVLLRWSLQLGNVVISRSSNPERIASNLDVFDFELTADHMDALDGLDDGTRF 262

AKR_AKR3F2

cd19139

Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; ...

16-299

1.46e-59

Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).

Pssm-ID: 381365 [Multi-domain] Cd Length: 248 Bit Score: 191.03 E-value: 1.46e-59

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  16 IPALGFGTTvpdKVPKDELIKATKIAIDTGFRHFDSAYLYQIEEEVGQAIRskieDGTVKREDIFYTSKLW-STFHRPEL 94
Cdd:cd19139   1 IPAFGLGTF---RLKDDVVIDSVRTALELGYRHIDTAQIYDNEAAVGQAIA----ESGVPRDELFITTKIWiDNLSKDKL 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  95 VRScLEKTLKNAQLDYVDLYIIHFPMalqpgdklfPRDEhgkllaeaVDLCDTWEAMEKCKDAGLAKSIGVSNFNFRQLE 174
Cdd:cd19139  74 LPS-LEESLEKLRTDYVDLTLIHWPS---------PNDE--------VPVEEYIGALAEAKEQGLTRHIGVSNFTIALLD 135

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 175 TILNKPGlKYKPVCNQVECHLYLNQSQMLDYCKSKDIILVSYCTLGSSRdkiwvdqkspvLLDDPVLCAMANKYKQTPAL 254
Cdd:cd19139 136 EAIAVVG-AGAIATNQIELSPYLQNRKLVAHCKQHGIHVTSYMTLAYGK-----------VLDDPVLAAIAERHGATPAQ 203

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 19527294 255 IAIRYQLQRGIVVLTRSFKEKRIKEFMKVFEFQLASEDMKVLDGL 299
Cdd:cd19139 204 IALAWAMARGYAVIPSSTKREHLRSNLLALDLTLDADDMAAIAAL 248

AKR_AKR5C1

cd19130

Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; ...

7-299

7.88e-59

Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; Corynebacterium sp. DkgA is a founding member of aldo-keto reductase family 5 member C1 (AKR5C1). DkgA (EC 1.1.1.346), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). 5-keto-D-fructose and dihydroxyacetone can also serve as substrates.

Pssm-ID: 381356 [Multi-domain] Cd Length: 256 Bit Score: 189.74 E-value: 7.88e-59

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294   7 RVVLNDGHFIPALGFGTTvpdKVPKDELIKATKIAIDTGFRHFDSAYLYQIEEEVGQAIRSKiedgTVKREDIFYTSKLW 86
Cdd:cd19130   1 SIVLNDGNSIPQLGYGVF---KVPPADTQRAVATALEVGYRHIDTAAIYGNEEGVGAAIAAS----GIPRDELFVTTKLW 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  87 STFHRPELVRSCLEKTLKNAQLDYVDLYIIHFPmalqpgdklfprdehgklLAEAVDLCDTWEAMEKCKDAGLAKSIGVS 166
Cdd:cd19130  74 NDRHDGDEPAAAFAESLAKLGLDQVDLYLVHWP------------------TPAAGNYVHTWEAMIELRAAGRTRSIGVS 135

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 167 NFNFRQLETILNKPGLKykPVCNQVECHLYLNQSQMLDYCKSKDIILVSYCTLGSSRdkiwvdqkspvLLDDPVLCAMAN 246
Cdd:cd19130 136 NFLPPHLERIVAATGVV--PAVNQIELHPAYQQRTIRDWAQAHDVKIEAWSPLGQGK-----------LLGDPPVGAIAA 202

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 19527294 247 KYKQTPALIAIRYQLQRGIVVLTRSFKEKRIKEFMKVFEFQLASEDMKVLDGL 299
Cdd:cd19130 203 AHGKTPAQIVLRWHLQKGHVVFPKSVRRERMEDNLDVFDFDLTDTEIAAIDAL 255

Aldo_ket_red

pfam00248

Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ...

19-299

4.22e-57

Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.

Pssm-ID: 425554 [Multi-domain] Cd Length: 290 Bit Score: 186.36 E-value: 4.22e-57

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294    19 LGFGT----TVPDKVPKDELIKATKIAIDTGFRHFDSAYLYQI---EEEVGQAIRSKiedgTVKREDIFYTSKL------ 85
Cdd:pfam00248   1 IGLGTwqlgGGWGPISKEEALEALRAALEAGINFIDTAEVYGDgksEELLGEALKDY----PVKRDKVVIATKVpdgdgp 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294    86 WSTFHRPELVRSCLEKTLKNAQLDYVDLYIIHFPmalqpgdklFPrdehgkllaeAVDLCDTWEAMEKCKDAGLAKSIGV 165
Cdd:pfam00248  77 WPSGGSKENIRKSLEESLKRLGTDYIDLYYLHWP---------DP----------DTPIEETWDALEELKKEGKIRAIGV 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294   166 SNFNFRQLETILNKPglKYKPVCNQVECHLY--LNQSQMLDYCKSKDIILVSYCTLGS----------------SRDKIW 227
Cdd:pfam00248 138 SNFDAEQIEKALTKG--KIPIVAVQVEYNLLrrRQEEELLEYCKKNGIPLIAYSPLGGglltgkytrdpdkgpgERRRLL 215

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19527294   228 VDQKSPVLLDDPVLCAMANKYKQTPALIAIRY--QLQRGIVVLTRSFKEKRIKEFMKVFEFQLASEDMKVLDGL 299
Cdd:pfam00248 216 KKGTPLNLEALEALEEIAKEHGVSPAQVALRWalSKPGVTIPIPGASNPEQLEDNLGALEFPLSDEEVARIDEL 289

AKR_AKR5B1

cd19127

AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) ...

8-299

5.64e-57

AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) is a founding member of the aldo-keto reductase family 5 member B1 (AKR5B1). M6DH (EC 1.1.1.218), also called naloxone reductase, oxidizes the C-6 hydroxy group of morphine and codeine.

Pssm-ID: 381353 [Multi-domain] Cd Length: 268 Bit Score: 185.30 E-value: 5.64e-57

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294   8 VVLNDGHFIPALGFGTTvpdKVPKDELIKATKIAIDTGFRHFDSAYLYQIEEEVGQAIRskiEDGtVKREDIFYTSKLWS 87
Cdd:cd19127   1 ITLNNGVEMPALGLGVF---QTPPEETADAVATALADGYRLIDTAAAYGNEREVGEGIR---RSG-VDRSDIFVTTKLWI 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  88 TFHRPELVRSCLEKTLKNAQLDYVDLYIIHFPMAlqpgdklfprdehgkllAEAVDLCDTWEAMEKCKDAGLAKSIGVSN 167
Cdd:cd19127  74 SDYGYDKALRGFDASLRRLGLDYVDLYLLHWPVP-----------------NDFDRTIQAYKALEKLLAEGRVRAIGVSN 136

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 168 FNFRQLETILNKPGLKykPVCNQVECHLYLNQSQMLDYCKSKDIILVSYCTLGS-SRDKIWVDQKSPVLLDDPVLCAMAN 246
Cdd:cd19127 137 FTPEHLERLIDATTVV--PAVNQVELHPYFSQKDLRAFHRRLGIVTQAWSPIGGvMRYGASGPTGPGDVLQDPTITGLAE 214

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 19527294 247 KYKQTPALIAIRYQLQRGIVVLTRSFKEKRIKEFMKVFEFQLASEDMKVLDGL 299
Cdd:cd19127 215 KYGKTPAQIVLRWHLQNGVSAIPKSVHPERIAENIDIFDFALSAEDMAAIDAL 267

AKR_AKR3F1-like

cd19072

Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime ...

16-297

1.01e-56

Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase. Escherichia coli YeaE may act as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.

Pssm-ID: 381298 [Multi-domain] Cd Length: 263 Bit Score: 184.35 E-value: 1.01e-56

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  16 IPALGFGT------TVPDKVPKDELIKATKIAIDTGFRHFDSAYLY---QIEEEVGQAIRskiedgTVKREDIFYTSKLW 86
Cdd:cd19072   4 VPVLGLGTwgigggMSKDYSDDKKAIEALRYAIELGINLIDTAEMYgggHAEELVGKAIK------GFDREDLFITTKVS 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  87 ST-FHRPELVRSClEKTLKNAQLDYVDLYIIHFPmalqpgdklfprdehgkllAEAVDLCDTWEAMEKCKDAGLAKSIGV 165
Cdd:cd19072  78 PDhLKYDDVIKAA-KESLKRLGTDYIDLYLIHWP-------------------NPSIPIEETLRAMEELVEEGKIRYIGV 137

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 166 SNFNFRQLETILNKPGlKYKPVCNQVECHLYLN--QSQMLDYCKSKDIILVSYCTLGssRDKIWVDQKSPVLLDdpvlca 243
Cdd:cd19072 138 SNFSLEELEEAQSYLK-KGPIVANQVEYNLFDReeESGLLPYCQKNGIAIIAYSPLE--KGKLSNAKGSPLLDE------ 208

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 19527294 244 MANKYKQTPALIAIRYQLQR-GIVVLTRSFKEKRIKEFMKVFEFQLASEDMKVLD 297
Cdd:cd19072 209 IAKKYGKTPAQIALNWLISKpNVIAIPKASNIEHLEENAGALGWELSEEDLQRLD 263

dkgA

PRK11565

2,5-didehydrogluconate reductase DkgA;

3-293

1.05e-55

2,5-didehydrogluconate reductase DkgA;

Pssm-ID: 183203 [Multi-domain] Cd Length: 275 Bit Score: 182.19 E-value: 1.05e-55

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294    3 SVSPRVVLNDGHFIPALGFGTTvpdKVPKDELIKATKIAIDTGFRHFDSAYLYQIEEEVGQAIRSkiedGTVKREDIFYT 82
Cdd:PRK11565   2 ANPTVIKLQDGNVMPQLGLGVW---QASNEEVITAIHKALEVGYRSIDTAAIYKNEEGVGKALKE----ASVAREELFIT 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294   83 SKLWSTFHRPelVRSCLEKTLKNAQLDYVDLYIIHFPMALQpgdklfprDEHgkllaeavdlCDTWEAMEKCKDAGLAKS 162
Cdd:PRK11565  75 TKLWNDDHKR--PREALEESLKKLQLDYVDLYLMHWPVPAI--------DHY----------VEAWKGMIELQKEGLIKS 134

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  163 IGVSNFNFRQLETILNKPGLKykPVCNQVECHLYLNQSQMLDYCKSKDIILVSYCTLGssrdkiwvdQKSPVLLDDPVLC 242
Cdd:PRK11565 135 IGVCNFQIHHLQRLIDETGVT--PVINQIELHPLMQQRQLHAWNATHKIQTESWSPLA---------QGGKGVFDQKVIR 203

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 19527294  243 AMANKYKQTPALIAIRYQLQRGIVVLTRSFKEKRIKEFMKVFEFQLASEDM 293
Cdd:PRK11565 204 DLADKYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVFDFRLDKDEL 254

dkgB

PRK11172

2,5-didehydrogluconate reductase DkgB;

16-304

1.96e-47

2,5-didehydrogluconate reductase DkgB;

Pssm-ID: 183012 [Multi-domain] Cd Length: 267 Bit Score: 160.57 E-value: 1.96e-47

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294   16 IPALGFGTTvpdKVPKDELIKATKIAIDTGFRHFDSAYLYQIEEEVGQAIRskiEDGtVKREDIFYTSKLW-STFHRPEL 94
Cdd:PRK11172   3 IPAFGLGTF---RLKDQVVIDSVKTALELGYRAIDTAQIYDNEAAVGQAIA---ESG-VPRDELFITTKIWiDNLAKDKL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294   95 VRScLEKTLKNAQLDYVDLYIIHFPmalQPGDKLfPRDEHGKLLAEAvdlcdtweamekcKDAGLAKSIGVSNFNFRQLE 174
Cdd:PRK11172  76 IPS-LKESLQKLRTDYVDLTLIHWP---SPNDEV-SVEEFMQALLEA-------------KKQGLTREIGISNFTIALMK 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  175 TILNKPGlKYKPVCNQVECHLYLNQSQMLDYCKSKDIILVSYCTLGSSRdkiwvdqkspvLLDDPVLCAMANKYKQTPAL 254
Cdd:PRK11172 138 QAIAAVG-AENIATNQIELSPYLQNRKVVAFAKEHGIHVTSYMTLAYGK-----------VLKDPVIARIAAKHNATPAQ 205

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 19527294  255 IAIRYQLQRGIVVLTRSFKEKRIKEFMKVFEFQLASEDMKVLDGLHRNLR 304
Cdd:PRK11172 206 VILAWAMQLGYSVIPSSTKRENLASNLLAQDLQLDAEDMAAIAALDRNGR 255

AKR_AKR3F1

cd19137

Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding ...

13-297

9.02e-43

Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase.

Pssm-ID: 381363 [Multi-domain] Cd Length: 260 Bit Score: 148.10 E-value: 9.02e-43

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  13 GHFIPALGFGT------TVPDKVPKDELIKATKIAIDTGFRHFDSAYLY---QIEEEVGQAIRSkiedgtVKREDIFYTS 83
Cdd:cd19137   1 GEKIPALGLGTwgiggfLTPDYSRDEEMVELLKTAIELGYTHIDTAEMYgggHTEELVGKAIKD------FPREDLFIVT 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  84 KLWSTFHRPELVRSCLEKTLKNAQLDYVDLYIIHFPmalqpgDKLFPRDEhgkllaeavdlcdTWEAMEKCKDAGLAKSI 163
Cdd:cd19137  75 KVWPTNLRYDDLLRSLQNSLRRLDTDYIDLYLIHWP------NPNIPLEE-------------TLSAMAEGVRQGLIRYI 135

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 164 GVSNFNFRQLETILNKpgLKYKPVCNQVECHLY---LNQSQMLDYCKSKDIILVSYCTLGSSrdkiwvdqkspVLLDDPV 240
Cdd:cd19137 136 GVSNFNRRLLEEAISK--SQTPIVCNQVKYNLEdrdPERDGLLEYCQKNGITVVAYSPLRRG-----------LEKTNRT 202

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 19527294 241 LCAMANKYKQTPALIAIRYQLQR-GIVVLTRSFKEKRIKEFMKVFEFQLASEDMKVLD 297
Cdd:cd19137 203 LEEIAKNYGKTIAQIALAWLIQKpNVVAIPKAGRVEHLKENLKATEIKLSEEEMKLLD 260

AKR_YeaE

cd19138

Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this ...

8-297

4.12e-42

Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this family. It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.

Pssm-ID: 381364 [Multi-domain] Cd Length: 266 Bit Score: 146.62 E-value: 4.12e-42

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294   8 VVLNDGHFIPALGFGT--TVPDKVPKDELIKATKIAIDTGFRHFDSAYLY---QIEEEVGQAIRSKiedgtvkREDIFYT 82
Cdd:cd19138   3 VTLPDGTKVPALGQGTwyMGEDPAKRAQEIEALRAGIDLGMTLIDTAEMYgdgGSEELVGEAIRGR-------RDKVFLV 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  83 SKLWSTFHRPELVRSCLEKTLKNAQLDYVDLYIIHFPmalqpgdklfprdehgkllaEAVDLCDTWEAMEKCKDAGLAKS 162
Cdd:cd19138  76 SKVLPSNASRQGTVRACERSLRRLGTDYLDLYLLHWR--------------------GGVPLAETVAAMEELKKEGKIRA 135

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 163 IGVSNFNFRQLETILNKPGLKyKPVCNQVECHLylnQSQ-----MLDYCKSKDIILVSYCTLGSSRDkiwvdqKSPVLLD 237
Cdd:cd19138 136 WGVSNFDTDDMEELWAVPGGG-NCAANQVLYNL---GSRgieydLLPWCREHGVPVMAYSPLAQGGL------LRRGLLE 205

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19527294 238 DPVLCAMANKYKQTPALIAIRYQLQRGIVV-LTRSFKEKRIKEFMKVFEFQLASEDMKVLD 297
Cdd:cd19138 206 NPTLKEIAARHGATPAQVALAWVLRDGNVIaIPKSGSPEHARENAAAADLELTEEDLAELD 266

PdxI

COG0667

Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme ...

16-301

9.24e-33

Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme transport and metabolism, General function prediction only];

Pssm-ID: 440431 [Multi-domain] Cd Length: 316 Bit Score: 123.36 E-value: 9.24e-33

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  16 IPALGFGT----TVPDKVPKDELIKATKIAIDTGFRHFDSAYLYQI---EEEVGQAIRSKiedgtvKREDIFYTSKLWST 88
Cdd:COG0667  13 VSRLGLGTmtfgGPWGGVDEAEAIAILDAALDAGINFFDTADVYGPgrsEELLGEALKGR------PRDDVVIATKVGRR 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  89 F--------HRPELVRSCLEKTLKNAQLDYVDLYIIHFPmalqpgdklfprDEHgkllaeaVDLCDTWEAMEKCKDAGLA 160
Cdd:COG0667  87 MgpgpngrgLSREHIRRAVEASLRRLGTDYIDLYQLHRP------------DPD-------TPIEETLGALDELVREGKI 147

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 161 KSIGVSNFNFRQLETILNKPGLKYKPVCNQVECHLyLNQS---QMLDYCKSKDIILVSYCTLGS--------------SR 223
Cdd:COG0667 148 RYIGVSNYSAEQLRRALAIAEGLPPIVAVQNEYSL-LDRSaeeELLPAARELGVGVLAYSPLAGglltgkyrrgatfpEG 226

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 224 DKIWVDQKSPVLLDD-----PVLCAMANKYKQTPALIAIRYQLQRGIVVL----TRSfkEKRIKEFMKVFEFQLASEDMK 294
Cdd:COG0667 227 DRAATNFVQGYLTERnlalvDALRAIAAEHGVTPAQLALAWLLAQPGVTSvipgARS--PEQLEENLAAADLELSAEDLA 304


                ....*..
gi 19527294 295 VLDGLHR 301
Cdd:COG0667 305 ALDAALA 311

AKR_AKR11B1-like

cd19084

AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called ...

13-297

4.94e-32

AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.

Pssm-ID: 381310 [Multi-domain] Cd Length: 296 Bit Score: 120.71 E-value: 4.94e-32

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  13 GHFIPALGFGT-----TVPDKVPKDELIKATKIAIDTGFRHFDSAYLY---QIEEEVGQAIRSKiedgtvkREDIFYTSK 84
Cdd:cd19084   1 DLKVSRIGLGTwaiggTWWGEVDDQESIEAIKAAIDLGINFFDTAPVYgfgHSEEILGKALKGR-------RDDVVIATK 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  85 ---LWSTFH------RPELVRSCLEKTLKNAQLDYVDLYIIHFPmalqpgdklfprDEhgkllaeAVDLCDTWEAMEKCK 155
Cdd:cd19084  74 cglRWDGGKgvtkdlSPESIRKEVEQSLRRLQTDYIDLYQIHWP------------DP-------NTPIEETAEALEKLK 134

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 156 DAGLAKSIGVSNFNFRQLETIlnkpgLKY-KPVCNQVECHLyLNQ---SQMLDYCKSKDIILVSYCTLGS-------SRD 224
Cdd:cd19084 135 KEGKIRYIGVSNFSVEQLEEA-----RKYgPIVSLQPPYSM-LEReieEELLPYCRENGIGVLPYGPLAQglltgkyKKE 208

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 225 KIWVD---------------QKSPVLLDdpVLCAMANKYKQTPALIAIRYQLQR--GIVVLTRSFKEKRIKEFMKVFEFQ 287
Cdd:cd19084 209 PTFPPddrrsrfpffrgenfEKNLEIVD--KLKEIAEKYGKSLAQLAIAWTLAQpgVTSAIVGAKNPEQLEENAGALDWE 286

                       330
                ....*....|
gi 19527294 288 LASEDMKVLD 297
Cdd:cd19084 287 LTEEELKEID 296

AKR_AtPLR-like

cd19093

Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR ...

31-297

5.05e-32

Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR (EC 1.1.1.65) is the prototype of this family. It catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+), and is involved in the PLP salvage pathway.

Pssm-ID: 381319 [Multi-domain] Cd Length: 293 Bit Score: 120.80 E-value: 5.05e-32

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  31 KDELIKATKIAIDTGFRHFDSAYLY---QIEEEVGQAIRskiedGTVKREDIFYTSKLWSTFHRPE---LVRSClEKTLK 104
Cdd:cd19093  25 DEDLQAAFDAALEAGVNLFDTAEVYgtgRSERLLGRFLK-----ELGDRDEVVIATKFAPLPWRLTrrsVVKAL-KASLE 98

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 105 NAQLDYVDLYIIHFPMALQPGDklfprdehgkllaeavdlCDTWEAMEKCKDAGLAKSIGVSNFNFRQLETI---LNKPG 181
Cdd:cd19093  99 RLGLDSIDLYQLHWPGPWYSQI------------------EALMDGLADAVEEGLVRAVGVSNYSADQLRRAhkaLKERG 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 182 lkYKPVCNQVECHL---YLNQSQMLDYCKSKDIILVSYCTLG---------------SSRDKIWVDQ---KSPVLLDdpV 240
Cdd:cd19093 161 --VPLASNQVEYSLlyrDPEQNGLLPACDELGITLIAYSPLAqglltgkyspenpppGGRRRLFGRKnleKVQPLLD--A 236

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 19527294 241 LCAMANKYKQTPALIAIRYQLQRGIVVL--TRSfkEKRIKEFMKVFEFQLASEDMKVLD 297
Cdd:cd19093 237 LEEIAEKYGKTPAQVALNWLIAKGVVPIpgAKN--AEQAEENAGALGWRLSEEEVAELD 293

AKR_AKR11B3

cd19085

Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is ...

16-303

2.27e-31

Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is a founding member of aldo-keto reductase family 11 member B3(AKR11B3). It is responsible for methylglyoxal detoxification.

Pssm-ID: 381311 [Multi-domain] Cd Length: 292 Bit Score: 119.23 E-value: 2.27e-31

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  16 IPALGFGT------TVPDKVPKDELIKATKIAIDTGFRHFDSAYLY---QIEEEVGQAIRSKiedgtvkREDIFYTSKLW 86
Cdd:cd19085   1 VSRLGLGCwqfgggYWWGDQDDEESIATIHAALDAGINFFDTAEAYgdgHSEEVLGKALKGR-------RDDVVIATKVS 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  87 STFHRPELVRSCLEKTLKNAQLDYVDLYIIHFPMalqpgdklfprdehgkllaEAVDLCDTWEAMEKCKDAGLAKSIGVS 166
Cdd:cd19085  74 PDNLTPEDVRKSCERSLKRLGTDYIDLYQIHWPS-------------------SDVPLEETMEALEKLKEEGKIRAIGVS 134

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 167 NFNFRQLETILnKPGlkyKPVCNQVECHLyLNQS---QMLDYCKSKDIILVSYCTLG--------SSRDKIWVDQK--SP 233
Cdd:cd19085 135 NFGPAQLEEAL-DAG---RIDSNQLPYNL-LWRAieyEILPFCREHGIGVLAYSPLAqglltgkfSSAEDFPPGDArtRL 209

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 234 VLLDDP-----------VLCAMANKYKQTPALIAIRYQLQRGIV--VLTRSFKEKRIKEFMKVFEFQLASEDMKVLDGLH 300
Cdd:cd19085 210 FRHFEPgaeeetfealeKLKEIADELGVTMAQLALAWVLQQPGVtsVIVGARNPEQLEENAAAVDLELSPSVLERLDEIS 289


                ...
gi 19527294 301 RNL 303
Cdd:cd19085 290 DPL 292

AKR_SF

cd06660

Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ...

17-221

4.30e-27

Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.

Pssm-ID: 381296 [Multi-domain] Cd Length: 232 Bit Score: 106.06 E-value: 4.30e-27

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  17 PALGFGT-TVPDKVPKDELIKATKIAIDTGFRHFDSAYLYQI---EEEVGQAIRSKiedgtVKREDIFYTSKLWSTFHR- 91
Cdd:cd06660   1 SRLGLGTmTFGGDGDEEEAFALLDAALEAGGNFFDTADVYGDgrsERLLGRWLKGR-----GNRDDVVIATKGGHPPGGd 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  92 -------PELVRSCLEKTLKNAQLDYVDLYIIHfpmalqpgdklfpRDEHGKLLAEavdlcdTWEAMEKCKDAGLAKSIG 164
Cdd:cd06660  76 psrsrlsPEHIRRDLEESLRRLGTDYIDLYYLH-------------RDDPSTPVEE------TLEALNELVREGKIRYIG 136

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19527294 165 VSNFNFRQLETILN--KPGLKYKPVCNQVECHLYLNQ---SQMLDYCKSKDIILVSYCTLGS 221
Cdd:cd06660 137 VSNWSAERLAEALAyaKAHGLPGFAAVQPQYSLLDRSpmeEELLDWAEENGLPLLAYSPLAR 198

AKR_AKR11A1_11D1

cd19083

AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto ...

19-299

6.56e-24

AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto reductase IolS, also called vegetative protein 147 (VEG147), is a founding member of aldo-keto reductase family 11 member A1 (AKR11A1). It is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose, and methylglyoxal in the presence of NADPH, albeit with poor efficiency in vitro. Bacillus aryabhattai aldo keto reductase is a founding member of aldo-keto reductase family 11 member D1 (AKR11D1).

Pssm-ID: 381309 [Multi-domain] Cd Length: 307 Bit Score: 99.42 E-value: 6.56e-24

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  19 LGFGTTV-------PDkVPKDELIKATKIAIDTGFRHFDSAYLYQI---EEEVGQAIRSKiedgtvKREDIFYTSKLWST 88
Cdd:cd19083  14 IGLGTNAvgghnlyPN-LDEEEGKDLVREALDNGVNLLDTAFIYGLgrsEELVGEVLKEY------NRNEVVIATKGAHK 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  89 F--------HRPELVRSCLEKTLKNAQLDYVDLYIIHFPmalqpgdklfprdEHGKLLAEAVDlcdtweAMEKCKDAGLA 160
Cdd:cd19083  87 FggdgsvlnNSPEFLRSAVEKSLKRLNTDYIDLYYIHFP-------------DGETPKAEAVG------ALQELKDEGKI 147

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 161 KSIGVSNFNFRQLETiLNKPGLkykpvCNQVE-CHLYLNQ---SQMLDYCKSKDIILVSYCTLGSS------------RD 224
Cdd:cd19083 148 RAIGVSNFSLEQLKE-ANKDGY-----VDVLQgEYNLLQReaeEDILPYCVENNISFIPYFPLASGllagkytkdtkfPD 221

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 225 KIWVDQKSpvLLDDPV----------LCAMANKYKQTPALIAIRYQLQR-GI-VVLTRSFKEKRIKEFMKVFEFQLASED 292
Cdd:cd19083 222 NDLRNDKP--LFKGERfsenldkvdkLKSIADEKGVTVAHLALAWYLTRpAIdVVIPGAKRAEQVIDNLKALDVTLTEEE 299


                ....*..
gi 19527294 293 MKVLDGL 299
Cdd:cd19083 300 IAFIDAL 306

AKR_BsYcsN_EcYdhF-like

cd19092

Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and ...

18-292

2.41e-23

Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and Escherichia coli YdhF are prototypes of this family. They are uncharacterized aldo/keto reductase family oxidoreductases.

Pssm-ID: 381318 [Multi-domain] Cd Length: 287 Bit Score: 97.24 E-value: 2.41e-23

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  18 ALGFGTTVPDKVPKDELIKATKIAIDTGFRHFDSA--Y-LYQIEEEVGQAIRSKiedgTVKREDIFYTSK---------- 84
Cdd:cd19092  10 VLGCMRLADWGESAEELLSLIEAALELGITTFDHAdiYgGGKCEELFGEALALN----PGLREKIEIQTKcgirlgddpr 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  85 LWSTFH---RPELVRSCLEKTLKNAQLDYVDLYIIHFPmalqpgDKLFPRDEhgkllaeavdlcdTWEAMEKCKDAGLAK 161
Cdd:cd19092  86 PGRIKHydtSKEHILASVEGSLKRLGTDYLDLLLLHRP------DPLMDPEE-------------VAEAFDELVKSGKVR 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 162 SIGVSNFNFRQLEtILNKpGLKYKPVCNQVEC---HLYLNQSQMLDYCKSKDIILVSYCTLGSSRDKIWVDQKSPVLLDd 238
Cdd:cd19092 147 YFGVSNFTPSQIE-LLQS-YLDQPLVTNQIELsllHTEAIDDGTLDYCQLLDITPMAWSPLGGGRLFGGFDERFQRLRA- 223

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 19527294 239 pVLCAMANKYKQTPALIAIRYqLQR---GIVVLTRSFKEKRIKEFMKVFEFQLASED 292
Cdd:cd19092 224 -ALEELAEEYGVTIEAIALAW-LLRhpaRIQPILGTTNPERIRSAVKALDIELTREE 278

YdhF

COG4989

Predicted oxidoreductase YdhF [General function prediction only];

31-292

2.94e-21

Predicted oxidoreductase YdhF [General function prediction only];

Pssm-ID: 444013 [Multi-domain] Cd Length: 299 Bit Score: 91.75 E-value: 2.94e-21

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  31 KDELIKATKIAIDTGFRHFDSA--Y-LYQIEEEVGQAI------RSKIE--------------DGTVKREDifyTSKLWs 87
Cdd:COG4989  30 PAEAAALIEAALELGITTFDHAdiYgGYTCEALFGEALklspslREKIElqtkcgirlpsearDNRVKHYD---TSKEH- 105

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  88 tfhrpeLVRSClEKTLKNAQLDYVDLYIIHFPmalqpgDKLFPRDEhgklLAEAVDlcdtweameKCKDAGLAKSIGVSN 167
Cdd:COG4989 106 ------IIASV-EGSLRRLGTDYLDLLLLHRP------DPLMDPEE----VAEAFD---------ELKASGKVRHFGVSN 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 168 FNFRQLEtILNKpGLKYKPVCNQVECHLYlnQSQM-----LDYCKSKDIILVSYCTLGSSRDKIWVDQKSPVLLDdpVLC 242
Cdd:COG4989 160 FTPSQFE-LLQS-ALDQPLVTNQIELSLL--HTDAfddgtLDYCQLNGITPMAWSPLAGGRLFGGFDEQFPRLRA--ALD 233

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 19527294 243 AMANKYKQTPALIAIRYqLQR---GIVVLTRSFKEKRIKEFMKVFEFQLASED 292
Cdd:COG4989 234 ELAEKYGVSPEAIALAW-LLRhpaGIQPVIGTTNPERIKAAAAALDIELTREE 285

COG1453

Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];

16-166

4.43e-17

Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];

Pssm-ID: 441062 [Multi-domain] Cd Length: 365 Bit Score: 80.63 E-value: 4.43e-17

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  16 IPALGFGTTVPDKVPKDELIKATKIAIDTGFRHFDSAYLY-QIEEEVGQAIRSKiedgtvkREDIFYTSKLWSTFHRPEL 94
Cdd:COG1453  13 VSVLGFGGMRLPRKDEEEAEALIRRAIDNGINYIDTARGYgDSEEFLGKALKGP-------RDKVILATKLPPWVRDPED 85

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19527294  95 VRSCLEKTLKNAQLDYVDLYIIHFPMALqpgdklfprdehgKLLAEAVDLCDTWEAMEKCKDAGLAKSIGVS 166
Cdd:COG1453  86 MRKDLEESLKRLQTDYIDLYLIHGLNTE-------------EDLEKVLKPGGALEALEKAKAEGKIRHIGFS 144

AKR_unchar

cd19100

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...

13-166

4.82e-17

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.

Pssm-ID: 381326 [Multi-domain] Cd Length: 238 Bit Score: 78.68 E-value: 4.82e-17

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  13 GHFIPALGFGTTVPDKVPKDELIKATKIAIDTGFRHFDSAYLYQI-EEEVGQAIRSKiedgtvkREDIFYTSKLWStfHR 91
Cdd:cd19100   8 GLKVSRLGFGGGPLGRLSQEEAAAIIRRALDLGINYFDTAPSYGDsEEKIGKALKGR-------RDKVFLATKTGA--RD 78

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19527294  92 PELVRSCLEKTLKNAQLDYVDLYIIHFPMALQPGDKLFprDEHGkllaeavdlcdTWEAMEKCKDAGLAKSIGVS 166
Cdd:cd19100  79 YEGAKRDLERSLKRLGTDYIDLYQLHAVDTEEDLDQVF--GPGG-----------ALEALLEAKEEGKIRFIGIS 140

AKR_unchar

cd19101

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...

6-297

1.15e-16

Pssm-ID: 381327 [Multi-domain] Cd Length: 304 Bit Score: 78.79 E-value: 1.15e-16

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294   6 PRVV-----LNDGHfipalgfgTTVPDKvpkDELIKATKIAIDTGFRHFDSAYLYQIEEE-VGQAIRSKIEDGTVKREDI 79
Cdd:cd19101   3 SRVIngmwqLSGGH--------GGIRDE---DAAVRAMAAYVDAGLTTFDCADIYGPAEElIGEFRKRLRRERDAADDVQ 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  80 FYTSklWSTFHR-----PELVRSCLEKTLKNAQLDYVDLyiihfpmaLQ-----PGDKLFprdehgkllaeavdlCDTWE 149
Cdd:cd19101  72 IHTK--WVPDPGeltmtRAYVEAAIDRSLKRLGVDRLDL--------VQfhwwdYSDPGY---------------LDAAK 126

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 150 AMEKCKDAGLAKSIGVSNFNFRQLETILNKPglkYKPVCNQVECHLyLNQ---SQMLDYCKSKDIILVSYCTLG----SS 222
Cdd:cd19101 127 HLAELQEEGKIRHLGLTNFDTERLREILDAG---VPIVSNQVQYSL-LDRrpeNGMAALCEDHGIKLLAYGTLAggllSE 202

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 223 RdkiWVDQKSP--------------VLLDD-----------PVLCAMANKYKQTPALIAIRYQLQR----GIVVLTRSfk 273
Cdd:cd19101 203 K---YLGVPEPtgpaletrslqkykLMIDEwggwdlfqellRTLKAIADKHGVSIANVAVRWVLDQpgvaGVIVGARN-- 277

                       330       340
                ....*....|....*....|....
gi 19527294 274 EKRIKEFMKVFEFQLASEDMKVLD 297
Cdd:cd19101 278 SEHIDDNVRAFSFRLDDEDRAAID 301

AKR_AKR11C1

cd19086

AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase ...

16-166

3.20e-16

AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase YqkF is a founding member of aldo-keto reductase family 11 member C1 (AKR11C1). It may function as oxidoreductase. This family also includes Bacillus halodurans AKR11C1, an NADPH-dependent 4-hydroxy-2,3-trans-nonenal reductase.

Pssm-ID: 381312 [Multi-domain] Cd Length: 238 Bit Score: 76.36 E-value: 3.20e-16

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  16 IPALGFGT-----TVPDKVPKDELIKATKIAIDTGFRHFDSAYLY---QIEEEVGQAIRSKiedgtvkREDIFYTSKL-- 85
Cdd:cd19086   3 VSEIGFGTwglggDWWGDVDDAEAIRALRAALDLGINFFDTADVYgdgHSERLLGKALKGR-------RDKVVIATKFgn 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  86 -------WSTFHRPELVRSCLEKTLKNAQLDYVDLYIIHfpmalQPGDKLFPRDEHgkllaeavdlcdtWEAMEKCKDAG 158
Cdd:cd19086  76 rfdggpeRPQDFSPEYIREAVEASLKRLGTDYIDLYQLH-----NPPDEVLDNDEL-------------FEALEKLKQEG 137


                ....*...
gi 19527294 159 LAKSIGVS 166
Cdd:cd19086 138 KIRAYGVS 145

AKR_AKR15A-like

cd19090

AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes ...

17-166

4.41e-16

AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH) and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. The family also includes L-galactose dehydrogenase (L-galDH) and D-arabinose 1-dehydrogenase (ARA2). L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).

Pssm-ID: 381316 [Multi-domain] Cd Length: 278 Bit Score: 76.82 E-value: 4.41e-16

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  17 PALGFGTT----VPDKVPKDELIKATKIAIDTGFRHFDSAYLY-QIEEEVGQAIRskiedgTVKREDIFYTSKLwSTFHR 91
Cdd:cd19090   1 SALGLGTAglggVFGGVDDDEAVATIRAALDLGINYIDTAPAYgDSEERLGLALA------ELPREPLVLSTKV-GRLPE 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  92 ------PELVRSCLEKTLKNAQLDYVDLYIIHFPMALQPGDKLFPrdehgkllAEAVdlcdtwEAMEKCKDAGLAKSIGV 165
Cdd:cd19090  74 dtadysADRVRRSVEESLERLGRDRIDLLMIHDPERVPWVDILAP--------GGAL------EALLELKEEGLIKHIGL 139


                .
gi 19527294 166 S 166
Cdd:cd19090 140 G 140

AKR_unchar

cd19099

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...

18-166

6.27e-16

Pssm-ID: 381325 [Multi-domain] Cd Length: 316 Bit Score: 76.97 E-value: 6.27e-16

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  18 ALGFGT--TVPDKVPKDELIKATKIAIDTGFRHFDSA--YLYQI-EEEVGQAIRSKIEDGTVKREDIFYTSK-------- 84
Cdd:cd19099   5 SLGLGTyrGDSDDETDEEYREALKAALDSGINVIDTAinYRGGRsERLIGKALRELIEKGGIKRDEVVIVTKagyipgdg 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  85 --------------------------LWSTFHrPELVRSCLEKTLKNAQLDYVDLYIIHFPMALQPGDKlfpRDEHGKLL 138
Cdd:cd19099  85 deplrplkyleeklgrglidvadsagLRHCIS-PAYLEDQIERSLKRLGLDTIDLYLLHNPEEQLLELG---EEEFYDRL 160

                       170       180
                ....*....|....*....|....*...
gi 19527294 139 AEAvdlcdtWEAMEKCKDAGLAKSIGVS 166
Cdd:cd19099 161 EEA------FEALEEAVAEGKIRYYGIS 182

AKR_AKR13B1

cd19088

AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde ...

16-268

8.08e-16

AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.

Pssm-ID: 381314 [Multi-domain] Cd Length: 256 Bit Score: 75.72 E-value: 8.08e-16

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  16 IPALGFGT---TVPD--KVPKDE-----LIKAtkiAIDTGFRHFDSAYLYQI---EEEVGQAIRSKIED-------GTVK 75
Cdd:cd19088   1 VSRLGYGAmrlTGPGiwGPPADReeaiaVLRR---ALELGVNFIDTADSYGPdvnERLIAEALHPYPDDvviatkgGLVR 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  76 REDifytsKLWSTFHRPELVRSCLEKTLKNAQLDYVDLYIIHFPMAlqpgdklfprdehgkllaeAVDLCDTWEAMEKCK 155
Cdd:cd19088  78 TGP-----GWWGPDGSPEYLRQAVEASLRRLGLDRIDLYQLHRIDP-------------------KVPFEEQLGALAELQ 133

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 156 DAGLAKSIGVSNFNFRQLETILNKPGLkykpVCNQVECHLYLNQS-QMLDYCKSKDIILVSYCTLGSSRDkiwvdqkspv 234
Cdd:cd19088 134 DEGLIRHIGLSNVTVAQIEEARAIVRI----VSVQNRYNLANRDDeGVLDYCEAAGIAFIPWFPLGGGDL---------- 199

                       250       260       270
                ....*....|....*....|....*....|....
gi 19527294 235 LLDDPVLCAMANKYKQTPALIAIRYQLQRGIVVL 268
Cdd:cd19088 200 AQPGGLLAEVAARLGATPAQVALAWLLARSPVML 233

AKR_unchar

cd19102

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...

32-299

8.32e-16

Pssm-ID: 381328 [Multi-domain] Cd Length: 302 Bit Score: 76.56 E-value: 8.32e-16

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  32 DELIKATKIAIDTGFRHFDSAYLYQI---EEEVGQAIRSKiedgtvkREDIFYTSK---LW------STFHRPELVRSCL 99
Cdd:cd19102  26 RDSIAAIRAALDLGINWIDTAAVYGLghsEEVVGRALKGL-------RDRPIVATKcglLWdeegriRRSLKPASIRAEC 98

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 100 EKTLKNAQLDYVDLYIIHFPmalqpgdklfprdehgkllAEAVDLCDTWEAMEKCKDAGLAKSIGVSNFNFRQLETIL-- 177
Cdd:cd19102  99 EASLRRLGVDVIDLYQIHWP-------------------DPDEPIEEAWGALAELKEEGKVRAIGVSNFSVDQMKRCQai 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 178 -----NKPGlkYKPVCNQVEchlylnqSQMLDYCKSKDIILVSYCTLGS-------SRDKI---WVD---QKSPV----- 234
Cdd:cd19102 160 hpiasLQPP--YSLLRRGIE-------AEILPFCAEHGIGVIVYSPMQSglltgkmTPERVaslPADdwrRRSPFfqepn 230

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19527294 235 ------LLDdpVLCAMANKYKQTPALIAIRYQLQR----GIVVLTRSfkEKRIKEFMKVFEFQLASEDMKVLDGL 299
Cdd:cd19102 231 larnlaLVD--ALRPIAERHGRTVAQLAIAWVLRRpevtSAIVGARR--PDQIDETVGAADLRLTPEELAEIEAL 301

AKR_PA4992-like

cd19095

Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the ...

17-169

2.73e-15

Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the prototype of this family. It is a putative aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.

Pssm-ID: 381321 [Multi-domain] Cd Length: 253 Bit Score: 74.19 E-value: 2.73e-15

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  17 PALGFGTT----VPDKVPKDELIKATKIAIDTGFRHFDSAYLY-QIEEEVGQAIRskiedgTVKREDIFYTSKLWSTF-- 89
Cdd:cd19095   1 SVLGLGTSgigrVWGVPSEAEAARLLNTALDLGINLIDTAPAYgRSEERLGRALA------GLRRDDLFIATKVGTHGeg 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  90 ------HRPELVRSCLEKTLKNAQLDYVDLYIIHFPMALQPGDKLFprdehgkllaeavdlcdtwEAMEKCKDAGLAKSI 163
Cdd:cd19095  75 grdrkdFSPAAIRASIERSLRRLGTDYIDLLQLHGPSDDELTGEVL-------------------ETLEDLKAAGKVRYI 135


                ....*.
gi 19527294 164 GVSNFN 169
Cdd:cd19095 136 GVSGDG 141

AKR_unchar

cd19103

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...

21-299

3.01e-15

Pssm-ID: 381329 [Multi-domain] Cd Length: 299 Bit Score: 74.68 E-value: 3.01e-15

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  21 FGTTVPDkvpkDELIKATKIAIDTGFRHFDSAYLYQI---EEEVGQAIRskiedgTVKREDIFYTSKLWSTF--HRPELV 95
Cdd:cd19103  25 FGNHLDE----DTLKAVFDKAMAAGLNLWDTAAVYGMgasEKILGEFLK------RYPREDYIISTKFTPQIagQSADPV 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  96 RSCLEKTLKNAQLDYVDLYIIHFPMALQpgdklfprdehgKLLAEAVDLcdtweamekcKDAGLAKSIGVSNFNFRQL-- 173
Cdd:cd19103  95 ADMLEGSLARLGTDYIDIYWIHNPADVE------------RWTPELIPL----------LKSGKVKHVGVSNHNLAEIkr 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 174 -ETILNKPGLKYKPVCNqvecH---LYLN--QSQMLDYCKSKDIILVSYCTL-----------------GSSRDKIW--V 228
Cdd:cd19103 153 aNEILAKAGVSLSAVQN----HyslLYRSseEAGILDYCKENGITFFAYMVLeqgalsgkydtkhplpeGSGRAETYnpL 228

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19527294 229 DQKSPVLLDdpVLCAMANKYKQTPALIAIRYQLQRGIVVLTRSFKEKRIKEFMKVFEFQLASEDMKVLDGL 299
Cdd:cd19103 229 LPQLEELTA--VMAEIGAKHGASIAQVAIAWAIAKGTTPIIGVTKPHHVEDAARAASITLTDDEIKELEQL 297

AKR_Fe-S_oxidoreductase

cd19096

Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S ...

17-166

3.35e-15

Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S oxidoreductase that belongs to aldo-keto reductase (AKR) superfamily. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.

Pssm-ID: 381322 [Multi-domain] Cd Length: 255 Bit Score: 74.13 E-value: 3.35e-15

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  17 PALGFGT-----TVPDKVPKDELIKATKIAIDTGFRHFDSAYLY---QIEEEVGQAIRskiedgTVKREDIFYTSKL-WS 87
Cdd:cd19096   1 SVLGFGTmrlpeSDDDSIDEEKAIEMIRYAIDAGINYFDTAYGYgggKSEEILGEALK------EGPREKFYLATKLpPW 74

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19527294  88 TFHRPELVRSCLEKTLKNAQLDYVDLYIIHfpmALQpgdklfpRDEHgkllAEAVDLCDTWEAMEKCKDAGLAKSIGVS 166
Cdd:cd19096  75 SVKSAEDFRRILEESLKRLGVDYIDFYLLH---GLN-------SPEW----LEKARKGGLLEFLEKAKKEGLIRHIGFS 139

AKR_unchar

cd19105

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...

6-166

3.74e-15

Pssm-ID: 381331 [Multi-domain] Cd Length: 250 Bit Score: 73.77 E-value: 3.74e-15

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294   6 PRVVL-NDGHFIPALGFGTTvPDKVPKDELIKAtkiAIDTGFRHFDSAYLYQI---EEEVGQAIRskiedgTVKREDIFY 81
Cdd:cd19105   2 PYRTLgKTGLKVSRLGFGGG-GLPRESPELLRR---ALDLGINYFDTAEGYGNgnsEEIIGEALK------GLRRDKVFL 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  82 TSKLWSTFH---RPELVRScLEKTLKNAQLDYVDLYIIHFPMALQpgdklfPRDEHGKLLaeavdlcdtwEAMEKCKDAG 158
Cdd:cd19105  72 ATKASPRLDkkdKAELLKS-VEESLKRLQTDYIDIYQLHGVDTPE------ERLLNEELL----------EALEKLKKEG 134


                ....*...
gi 19527294 159 LAKSIGVS 166
Cdd:cd19105 135 KVRFIGFS 142

AKR_AKR11B2

cd19149

Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; ...

16-297

2.85e-14

Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.

Pssm-ID: 381375 [Multi-domain] Cd Length: 315 Bit Score: 72.31 E-value: 2.85e-14

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  16 IPALGFGT------TVPDKVPKDELIKATKIAIDTGFRHFDSAYLYQI---EEEVGQAIRSKIED-------GTV---KR 76
Cdd:cd19149  11 ASVIGLGTwaigggPWWGGSDDNESIRTIHAALDLGINLIDTAPAYGFghsEEIVGKAIKGRRDKvvlatkcGLRwdrEG 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  77 EDIFYTSKLWSTFH--RPELVRSCLEKTLKNAQLDYVDLYIIHFPmalqpgDKLFPRDEhgkllaeavdlcdTWEAMEKC 154
Cdd:cd19149  91 GSFFFVRDGVTVYKnlSPESIREEVEQSLKRLGTDYIDLYQTHWQ------DVETPIEE-------------TMEALEEL 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 155 KDAGLAKSIGVSNFNFRQLETILNkpglkykpvCNQVEchlyLNQSQ--MLD---------YCKSKDIILVSYCTL---- 219
Cdd:cd19149 152 KRQGKIRAIGASNVSVEQIKEYVK---------AGQLD----IIQEKysMLDrgiekellpYCKKNNIAFQAYSPLeqgl 218

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 220 -------------GSSRDKIWVDQKSPVL----LDDPVLcAMANKYKQTPALIAIRYQLQRG--IVVLTRSFKEKRIKEF 280
Cdd:cd19149 219 ltgkitpdrefdaGDARSGIPWFSPENREkvlaLLEKWK-PLCEKYGCTLAQLVIAWTLAQPgiTSALCGARKPEQAEEN 297

                       330
                ....*....|....*..
gi 19527294 281 MKVFEFQLASEDMKVLD 297
Cdd:cd19149 298 AKAGDIRLSAEDIATMR 314

AKR_EcYajO-like

cd19079

Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this ...

28-297

4.80e-14

Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.

Pssm-ID: 381305 [Multi-domain] Cd Length: 312 Bit Score: 71.46 E-value: 4.80e-14

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  28 KVPKDELIKATKIAIDTGFRHFDSAYLYQI---EEEVGQAIRSKIedgtvKREDIFYTSKLW---------STFHRPELV 95
Cdd:cd19079  31 VLDEEESRPIIKRALDLGINFFDTANVYSGgasEEILGRALKEFA-----PRDEVVIATKVYfpmgdgpngRGLSRKHIM 105

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  96 RSClEKTLKNAQLDYVDLYIIHFPmalqpgdklfprDEHgkllaeaVDLCDTWEAMEKCKDAGLAKSIGVSNF---NFRQ 172
Cdd:cd19079 106 AEV-DASLKRLGTDYIDLYQIHRW------------DYE-------TPIEETLEALHDVVKSGKVRYIGASSMyawQFAK 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 173 LETILNKPGLKyKPVCNQvechLYLN------QSQMLDYCKSKDIILVSYCTLGSSR---------DKIWVDQKSPVL-- 235
Cdd:cd19079 166 ALHLAEKNGWT-KFVSMQ----NHYNllyreeEREMIPLCEEEGIGVIPWSPLARGRlarpwgdttERRRSTTDTAKLky 240

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19527294 236 -----LDDPVLCA---MANKYKQTPALIAIRYQLQRG-----IVVLTrsfKEKRIKEFMKVFEFQLASEDMKVLD 297
Cdd:cd19079 241 dyfteADKEIVDRveeVAKERGVSMAQVALAWLLSKPgvtapIVGAT---KLEHLEDAVAALDIKLSEEEIKYLE 312

AKR_AKR11B1

cd19148

Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also ...

32-297

3.26e-13

Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.

Pssm-ID: 381374 [Multi-domain] Cd Length: 302 Bit Score: 68.87 E-value: 3.26e-13

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  32 DELIKATKIAIDTGFRHFDSAYLY---QIEEEVGQAIRskiedGTVKREDIFYTSKL---WSTFH------RPELVRSCL 99
Cdd:cd19148  25 KEAIETIHKALDLGINLIDTAPVYgfgLSEEIVGKALK-----EYGKRDRVVIATKVgleWDEGGevvrnsSPARIRKEV 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 100 EKTLKNAQLDYVDLYIIHFPmalqpgDKLFPRDEhgkllaeavdlcdTWEAMEKCKDAGLAKSIGVSNFNFRQLETILNK 179
Cdd:cd19148 100 EDSLRRLQTDYIDLYQVHWP------DPLVPIEE-------------TAEALKELLDEGKIRAIGVSNFSPEQMETFRKV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 180 PGLK-YKPVCNQVECHLylnQSQMLDYCKSKDIILVSYCTL--GSSRDKIWVDQKSP---VLLDDPV------------- 240
Cdd:cd19148 161 APLHtVQPPYNLFEREI---EKDVLPYARKHNIVTLAYGALcrGLLSGKMTKDTKFEgddLRRTDPKfqeprfsqylaav 237

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19527294 241 --LCAMANK-YKQTPALIAIRYQLQRGI--VVLTRSFKEKRIKEFMKVFEFQLASEDMKVLD 297
Cdd:cd19148 238 eeLDKLAQErYGKSVIHLAVRWLLDQPGvsIALWGARKPEQLDAVDEVFGWSLNDEDMKEID 299

AKR_PsAKR

cd19091

Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an ...

11-297

7.00e-13

Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an uncharacterized aldo-keto reductase from Polaromonas sp.

Pssm-ID: 381317 [Multi-domain] Cd Length: 319 Bit Score: 68.02 E-value: 7.00e-13

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  11 NDGHFIPALGFGT-TVPDK---------VPKDELIKATKIAIDTGFRHFDSAYLY---QIEEEVGQAIRSKiedgtvkRE 77
Cdd:cd19091   8 RSGLKVSELALGTmTFGGGggffgawggVDQEEADRLVDIALDAGINFFDTADVYsegESEEILGKALKGR-------RD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  78 DIFYTSKLWSTF---------HRPELVRSClEKTLKNAQLDYVDLYIIHFPmalqpgDKLFPRDEhgkllaeavdlcdTW 148
Cdd:cd19091  81 DVLIATKVRGRMgegpndvglSRHHIIRAV-EASLKRLGTDYIDLYQLHGF------DALTPLEE-------------TL 140

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 149 EAMEKCKDAGLAKSIGVSNFNFRQLETIL---NKPGLKyKPVCNQVECHLyLNQS---QMLDYCKSKDIILVSYCTLGSS 222
Cdd:cd19091 141 RALDDLVRQGKVRYIGVSNFSAWQIMKALgisERRGLA-RFVALQAYYSL-LGRDlehELMPLALDQGVGLLVWSPLAGG 218

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 223 R--DKIWVDQKSP------------VLLDDP-------VLCAMANKYKQTPALIAIRYQLQRGIV--VLTRSFKEKRIKE 279
Cdd:cd19091 219 LlsGKYRRGQPAPegsrlrrtgfdfPPVDRErgydvvdALREIAKETGATPAQVALAWLLSRPTVssVIIGARNEEQLED 298

                       330
                ....*....|....*...
gi 19527294 280 FMKVFEFQLASEDMKVLD 297
Cdd:cd19091 299 NLGAAGLSLTPEEIARLD 316

AKR_galDH

cd19163

L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called ...

16-220

9.79e-13

L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+).

Pssm-ID: 381389 [Multi-domain] Cd Length: 293 Bit Score: 67.58 E-value: 9.79e-13

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  16 IPALGFGT----TVPDKVPKDELIKATKIAIDTGFRHFDSAYLYQI---EEEVGQAIRskiedgTVKREDIF-------Y 81
Cdd:cd19163  13 VSKLGFGAsplgGVFGPVDEEEAIRTVHEALDSGINYIDTAPWYGQgrsETVLGKALK------GIPRDSYYlatkvgrY 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  82 TSKLWSTF-HRPELVRSCLEKTLKNAQLDYVDLYIIHFPmalqpgdklfprdEHGKLLAEAVDlcDTWEAMEKCKDAGLA 160
Cdd:cd19163  87 GLDPDKMFdFSAERITKSVEESLKRLGLDYIDIIQVHDI-------------EFAPSLDQILN--ETLPALQKLKEEGKV 151

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19527294 161 KSIGVSNFNFRQLETILNKPG------LKYkpvcnqveCHLYLNQS---QMLDYCKSKDIILVSYCTLG 220
Cdd:cd19163 152 RFIGITGYPLDVLKEVLERSPvkidtvLSY--------CHYTLNDTsllELLPFFKEKGVGVINASPLS 212

Aldo_ket_red_shaker-like

cd19074

Shaker potassium channel beta subunit family and similar proteins; This family includes ...

19-216

3.03e-12

Shaker potassium channel beta subunit family and similar proteins; This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. The family also includes Drosophila melanogaster Hk protein, a founding member of aldo-keto reductase family 6 member B1 (AKR6B1), as well as voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa, founding members of AKR6C1and AKR6C2, respectively. Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.

Pssm-ID: 381300 [Multi-domain] Cd Length: 297 Bit Score: 66.08 E-value: 3.03e-12

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  19 LGFGT--TVPDKVPKDELIKATKIAIDTGFRHFDSAYLY---QIEEEVGQAIRskiedgTVKREDIFYTSKL-WST---- 88
Cdd:cd19074   7 LSLGTwlTFGGQVDDEDAKACVRKAYDLGINFFDTADVYaagQAEEVLGKALK------GWPRESYVISTKVfWPTgpgp 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  89 ----FHRPELVRSClEKTLKNAQLDYVDLYIIHFPmalqpgDKLFPRDEhgkllaeavdlcdTWEAMEKCKDAGLAKSIG 164
Cdd:cd19074  81 ndrgLSRKHIFESI-HASLKRLQLDYVDIYYCHRY------DPETPLEE-------------TVRAMDDLIRQGKILYWG 140

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 19527294 165 VSNFNFRQLE---TILNKPGLkYKPVCNQVECHLyLNQ---SQMLDYCKSKDIILVSY 216
Cdd:cd19074 141 TSEWSAEQIAeahDLARQFGL-IPPVVEQPQYNM-LWReieEEVIPLCEKNGIGLVVW 196

AKR_AKR13A_13D

cd19076

AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto ...

16-166

3.16e-12

AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor. Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.

Pssm-ID: 381302 [Multi-domain] Cd Length: 303 Bit Score: 66.09 E-value: 3.16e-12

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  16 IPALGFG----TTVPDKVPKDELIKATKIAIDTGFRHFDSAYLYQI---EEEVGQAIRSKiedgtvkREDIFYTSK---L 85
Cdd:cd19076  12 VSALGLGcmgmSAFYGPADEEESIATLHRALELGVTFLDTADMYGPgtnEELLGKALKDR-------RDEVVIATKfgiV 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  86 WSTFH-------RPELVRSCLEKTLKNAQLDYVDLYIIHFPmalqpgDKlfprdehgkllaeAVDLCDTWEAMEKCKDAG 158
Cdd:cd19076  85 RDPGSgfrgvdgRPEYVRAACEASLKRLGTDVIDLYYQHRV------DP-------------NVPIEETVGAMAELVEEG 145


                ....*...
gi 19527294 159 LAKSIGVS 166
Cdd:cd19076 146 KVRYIGLS 153

AKR_unchar

cd19097

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...

28-184

1.14e-11

Pssm-ID: 381323 [Multi-domain] Cd Length: 267 Bit Score: 64.09 E-value: 1.14e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  28 KVPKDELIKATKIAIDTGFRHFDSAYLYQIEEEV-GQAIRSKiedgtvkrEDIFYTSKL----WSTFHRPELVRSCLEKT 102
Cdd:cd19097  22 KPSEKEAKKILEYALKAGINTLDTAPAYGDSEKVlGKFLKRL--------DKFKIITKLpplkEDKKEDEAAIEASVEAS 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 103 LKNAQLDYVDLYIIHFPMALqpgdklfprDEHGKLLaeavdlcdtWEAMEKCKDAGLAKSIGVSNFNFRQLETILNKPGL 182
Cdd:cd19097  94 LKRLKVDSLDGLLLHNPDDL---------LKHGGKL---------VEALLELKKEGLIRKIGVSVYSPEELEKALESFKI 155


                ..
gi 19527294 183 KY 184
Cdd:cd19097 156 DI 157

AKR_FDH

cd19162

D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S, ...

17-166

2.14e-10

D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.

Pssm-ID: 381388 [Multi-domain] Cd Length: 290 Bit Score: 60.45 E-value: 2.14e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  17 PALGFGTTV---PDKVPKDELIKATKIAIDTGFRHFDSAYLY---QIEEEVGQAIRSKiedgtvKREDIFYTSKL----- 85
Cdd:cd19162   1 PRLGLGAASlgnLARAGEDEAAATLDAAWDAGIRYFDTAPLYglgLSERRLGAALARH------PRAEYVVSTKVgrlle 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  86 -----WSTFHRPEL------VRSCLEKTLKNAQLDYVDLYIIHFPmalqpgdklfprDEHgklLAEAVDlcDTWEAMEKC 154
Cdd:cd19162  75 pgaagRPAGADRRFdfsadgIRRSIEASLERLGLDRLDLVFLHDP------------DRH---LLQALT--DAFPALEEL 137

                       170
                ....*....|..
gi 19527294 155 KDAGLAKSIGVS 166
Cdd:cd19162 138 RAEGVVGAIGVG 149

AKR_AKR13A1

cd19144

AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC ...

6-294

2.91e-10

AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor.

Pssm-ID: 381370 [Multi-domain] Cd Length: 323 Bit Score: 60.53 E-value: 2.91e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294   6 PRVVL-NDGHFIPALGFGTT------VPDKvPKDELIKATKIAIDTGFRHFDSAYLYQIEEEVgqaIRSKIEDGTVKRED 78
Cdd:cd19144   2 PTRTLgRNGPSVPALGFGAMglsafyGPPK-PDEERFAVLDAAFELGCTFWDTADIYGDSEEL---IGRWFKQNPGKREK 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  79 IFYTSKL----------WSTFHRPELVRSCLEKTLKNAQLDYVDLYIIHFPMALQPGDKlfprdehgkllaeavdlcdTW 148
Cdd:cd19144  78 IFLATKFgieknvetgeYSVDGSPEYVKKACETSLKRLGVDYIDLYYQHRVDGKTPIEK-------------------TV 138

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 149 EAMEKCKDAGLAKSIGVSNFNfrqLETI--------LNKPGLKYKPVCNQVEchlyLNQSQMLDYCKSKDIILVSYCTLG 220
Cdd:cd19144 139 AAMAELVQEGKIKHIGLSECS---AETLrrahavhpIAAVQIEYSPFSLDIE----RPEIGVLDTCRELGVAIVAYSPLG 211

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 221 --------SSRDKIWVDQ--------------KSPVLLDDpvLCAMANKYKQTPALIAIRYQLQRG--IVVLTRSFKEKR 276
Cdd:cd19144 212 rgfltgaiRSPDDFEEGDfrrmaprfqaenfpKNLELVDK--IKAIAKKKNVTAGQLTLAWLLAQGddIIPIPGTTKLKR 289

                       330
                ....*....|....*...
gi 19527294 277 IKEFMKVFEFQLASEDMK 294
Cdd:cd19144 290 LEENLGALKVKLTEEEEK 307

AKR_unchar

cd19104

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...

32-166

4.54e-10

Pssm-ID: 381330 [Multi-domain] Cd Length: 321 Bit Score: 59.59 E-value: 4.54e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  32 DELIKATKIAIDTGFRHFDSAYLY---QIEEEVGQAIRSKiedgtvkREDIFYTSKLWSTFHRPE-----LVRScLEKTL 103
Cdd:cd19104  32 EEQIAAVRRALDLGINFFDTAPSYgdgKSEENLGRALKGL-------PAGPYITTKVRLDPDDLGdiggqIERS-VEKSL 103

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 19527294 104 KNAQLDYVDLYIIHfpmalqpgDKLFPRDEHGKLLAEAVD----LCDTWEAMEKCKDAGLAKSIGVS 166
Cdd:cd19104 104 KRLKRDSVDLLQLH--------NRIGDERDKPVGGTLSTTdvlgLGGVADAFERLRSEGKIRFIGIT 162

AKR_Tas-like

cd19094

Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the ...

41-220

4.14e-09

Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the prototype of this family. It is an NADP(H)-dependent aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NADP(H) as a hydride donor.

Pssm-ID: 381320 [Multi-domain] Cd Length: 328 Bit Score: 56.80 E-value: 4.14e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  41 AIDTGFRHFDSAYLYQI----------EEEVGQAIRSKiedgtVKREDIFYTSK-----LWSTFHR-------PELVRSC 98
Cdd:cd19094  27 AFDEGVNFIDTAEMYPVppspetqgrtEEIIGSWLKKK-----GNRDKVVLATKvagpgEGITWPRgggtrldRENIREA 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  99 LEKTLKNAQLDYVDLYIIHFPMALQP-GDKLFPRDEHGKllAEAVDLCDTWEAMEKCKDAGLAKSIGVSN------FNFR 171
Cdd:cd19094 102 VEGSLKRLGTDYIDLYQLHWPDRYTPlFGGGYYTEPSEE--EDSVSFEEQLEALGELVKAGKIRHIGLSNetpwgvMKFL 179

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 19527294 172 QLETILNKPglkyKPVCNQVECHLyLNQS---QMLDYCKSKDIILVSYCTLG 220
Cdd:cd19094 180 ELAEQLGLP----RIVSIQNPYSL-LNRNfeeGLAEACHRENVGLLAYSPLA 226

AKR_AKR12A1_B1_C1

cd19087

AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, ...

41-168

9.84e-09

AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, Saccharopolyspora erythraea EryBII, and Streptomyces avermitilis aveBVIII are founding members of aldo-keto reductase family 12 member A1 (AKR12A1), B1 (AKR12B1), and C1(AKR12C1), respectively. TylCII acts as a NDP-hexose 2,3-enoyl reductase. EryBII is a mycarose/desosamine reductase involved in L-mycarose and D-desosamine production. aveBVIII functions as a dTDP-4-keto-6-deoxy-L-hexose-2,3-reductase.

Pssm-ID: 381313 [Multi-domain] Cd Length: 310 Bit Score: 55.66 E-value: 9.84e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  41 AIDTGFRHFDSAYLY---QIEEEVGQAIRSKiedgtvkREDIFYTSKlwstFHRP-------------ELVRSClEKTLK 104
Cdd:cd19087  39 ALDAGINFFDTADVYgggRSEEIIGRWIAGR-------RDDIVLATK----VFGPmgddpndrglsrrHIRRAV-EASLR 106

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19527294 105 NAQLDYVDLYIIHFPmalqpgDKLFPRDEhgkllaeavdlcdTWEAMEKCKDAGLAKSIGVSNF 168
Cdd:cd19087 107 RLQTDYIDLYQMHHF------DRDTPLEE-------------TLRALDDLVRQGKIRYIGVSNF 151

AKR_AKR13D1

cd19145

AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of ...

6-296

1.91e-08

AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.

Pssm-ID: 381371 [Multi-domain] Cd Length: 304 Bit Score: 54.75 E-value: 1.91e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294   6 PRVVL-NDGHFIPALGFG-----TTVPDKVPKDELIKATKIAIDTGFRHFDSAYLY---QIEEEVGQAI----RSKIEDG 72
Cdd:cd19145   1 PRVKLgSQGLEVSAQGLGcmglsGDYGAPKPEEEGIALIHHAFNSGVTFLDTSDIYgpnTNEVLLGKALkdgpREKVQLA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  73 TvkREDIFYTSKLWSTFH-RPELVRSCLEKTLKNAQLDYVDLYIIHfpmalqpgdklfpRDEHgkllaeAVDLCDTWEAM 151
Cdd:cd19145  81 T--KFGIHEIGGSGVEVRgDPAYVRAACEASLKRLDVDYIDLYYQH-------------RIDT------TVPIEITMGEL 139

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 152 EKCKDAGLAKSIGVSNfnfRQLETILNKPGLkyKPVCN-QVECHLYLN--QSQMLDYCKSKDIILVSYCTLG-------- 220
Cdd:cd19145 140 KKLVEEGKIKYIGLSE---ASADTIRRAHAV--HPITAvQLEWSLWTRdiEEEIIPTCRELGIGIVPYSPLGrgffagka 214

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 221 ---SSRDKIWVDQKSPVLLDDPV---------LCAMANKYKQTPALIAIRYQLQRG--IVVLTRSFKEKRIKEFMKVFEF 286
Cdd:cd19145 215 kleELLENSDVRKSHPRFQGENLeknkvlyerVEALAKKKGCTPAQLALAWVLHQGedVVPIPGTTKIKNLNQNIGALSV 294

                       330
                ....*....|
gi 19527294 287 QLASEDMKVL 296
Cdd:cd19145 295 KLTKEDLKEI 304

AKR_AKR9C1

cd19081

AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a ...

58-297

3.47e-08

AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a founding member of aldo-keto reductase family 9 member C1 (AKR9C1).

Pssm-ID: 381307 [Multi-domain] Cd Length: 308 Bit Score: 54.14 E-value: 3.47e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  58 EEEVGQAIRSKiedgtVKREDIFYTSKL--WSTFHRPEL----VRSCLEKTLKNAQLDYVDLYIIHFPmalqpgDklfpr 131
Cdd:cd19081  62 ETIIGRWLKSR-----GKRDRVVIATKVgfPMGPNGPGLsrkhIRRAVEASLRRLQTDYIDLYQAHWD------D----- 125

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 132 dehgkllaEAVDLCDTWEAMEKCKDAGLAKSIGVSNFNFRQLETILN---KPGLKyKPVCNQVECHLYLNQS---QMLDY 205
Cdd:cd19081 126 --------PATPLEETLGALNDLIRQGKVRYIGASNYSAWRLQEALElsrQHGLP-RYVSLQPEYNLVDRESfegELLPL 196

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 206 CKSKDIILVSYCTL----------------GSSRDKIWVDQkspvLLDDP------VLCAMANKYKQTPALIAIRYQLQR 263
Cdd:cd19081 197 CREEGIGVIPYSPLaggfltgkyrseadlpGSTRRGEAAKR----YLNERglrildALDEVAAEHGATPAQVALAWLLAR 272

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 19527294 264 GIV--VLTRSFKEKRIKEFMKVFEFQLASEDMKVLD 297
Cdd:cd19081 273 PGVtaPIAGARTVEQLEDLLAAAGLRLTDEEVARLD 308

AKR_AKR6C1_2

cd19143

AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) ...

18-195

1.21e-07

AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa are founding members of aldo-keto reductase family 6 member C1 (AKR6C1) and C2 (AKR6C2), respectively. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.

Pssm-ID: 381369 [Multi-domain] Cd Length: 319 Bit Score: 52.21 E-value: 1.21e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  18 ALGFG--TTVPDKVPKDELIKATKIAIDTGFRHFDSAYLY---QIEEEVGQAIRskieDGTVKREDIFYTSKL-W----- 86
Cdd:cd19143  15 ALSFGswVTFGNQVDVDEAKECMKAAYDAGVNFFDNAEVYangQSEEIMGQAIK----ELGWPRSDYVVSTKIfWggggp 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  87 ----STFHRPELVRSClEKTLKNAQLDYVDLYIIHFPmalqpgDKLFPRDEhgkllaeavdlcdTWEAMEKCKDAGLAKS 162
Cdd:cd19143  91 ppndRGLSRKHIVEGT-KASLKRLQLDYVDLVFCHRP------DPATPIEE-------------TVRAMNDLIDQGKAFY 150

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 19527294 163 IGVSNFNFRQLET---ILNKPGLkYKPVCNQVECHL 195
Cdd:cd19143 151 WGTSEWSAQQIEEaheIADRLGL-IPPVMEQPQYNL 185

AKR_AKR7A1-5

cd19075

AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1 ...

6-192

1.34e-07

AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1/AKR7A3/AFAR) from Rattus norvegicus, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR1/AFAR) and aflatoxin B1 aldehyde reductase member 3 (AKR7A3/AFAR2) from Homo sapiens, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR2) from Rattus norvegicus, and aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AKR7A5/AFAR) from Mus musculus, are founding members of aldo-keto reductase family 7 member A1-5 (AKR7A1-5), respectively. AKR7A2 (EC 1.1.1.n11), also called AFB1 aldehyde reductase 1, or AFB1-AR 1, or aldoketoreductase 7, or succinic semialdehyde reductase, or SSA reductase, catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate (GHB). It has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). AKR7A2, AKR7A3 (also called AFB1 aldehyde reductase 2 or AFB1-AR 2), and AKR7A4 (also called AFB1 aldehyde reductase 3, or AFB1-AR 3, or aldoketoreductase 7-like), may be involved in protection of liver against the toxic and carcinogenic effects of aflatoxin B1 (AFB1), a potent hepatocarcinogen. They can reduce the dialdehyde protein-binding form of AFB1 to the non-binding AFB1 dialcohol.

Pssm-ID: 381301 [Multi-domain] Cd Length: 304 Bit Score: 52.17 E-value: 1.34e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294   6 PRVVLNDGHFIPALGFGTtvPDKVpkDELIKATKiaiDTGFRHFDSAYLY---QIEEEVGQAiRSKIEDGTV--Kredif 80
Cdd:cd19075   1 PKIILGTMTFGSQGRFTT--AEAA--AELLDAFL---ERGHTEIDTARVYpdgTSEELLGEL-GLGERGFKIdtK----- 67

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  81 yTSKLWSTFHRPELVRSCLEKTLKNAQLDYVDLYIIHFPmalqpgDklfprdehgkllaEAVDLCDTWEAMEKCKDAGLA 160
Cdd:cd19075  68 -ANPGVGGGLSPENVRKQLETSLKRLKVDKVDVFYLHAP------D-------------RSTPLEETLAAIDELYKEGKF 127

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 19527294 161 KSIGVSNFNFRQLETILN--------KP----GLkYKPVCNQVE 192
Cdd:cd19075 128 KEFGLSNYSAWEVAEIVEickengwvLPtvyqGM-YNAITRQVE 170

AKR_AKR13C1_2

cd19078

AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli ...

18-297

2.15e-07

AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli aldehyde reductase (AKR13C1) and Thermotoga maritima aldo-keto reductase (AKR13C2). Aldehyde reductase (EC 1.1.1.21), also called aldose reductase, is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides.

Pssm-ID: 381304 [Multi-domain] Cd Length: 301 Bit Score: 51.46 E-value: 2.15e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  18 ALGFGT--------TVPDKvpkDELIKATKIAIDTGFRHFDSAYLY---QIEEEVGQAIRSKiedgtvkREDIFYTSKLW 86
Cdd:cd19078   6 AIGLGCmgmshgygPPPDK---EEMIELIRKAVELGITFFDTAEVYgpyTNEELVGEALKPF-------RDQVVIATKFG 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  87 STFH-----------RPELVRSCLEKTLKNAQLDYVDLYIIHFPmalqpgDKLFPrdehgkllAEAVDlcdtwEAMEKCK 155
Cdd:cd19078  76 FKIDggkpgplgldsRPEHIRKAVEGSLKRLQTDYIDLYYQHRV------DPNVP--------IEEVA-----GTMKELI 136

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 156 DAGLAKSIGVSNFNfrqLETIlnKPGLKYKPVCN-QVECHLYLN--QSQMLDYCKSKDIILVSYCTLG------------ 220
Cdd:cd19078 137 KEGKIRHWGLSEAG---VETI--RRAHAVCPVTAvQSEYSMMWRepEKEVLPTLEELGIGFVPFSPLGkgfltgkident 211

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 221 ---SSRDKIWVDQKSP-------VLLDdpVLCAMANKYKQTPALIAIRYQLQRG--IVVLTRSFKEKRIKEFMKVFEFQL 288
Cdd:cd19078 212 kfdEGDDRASLPRFTPealeanqALVD--LLKEFAEEKGATPAQIALAWLLAKKpwIVPIPGTTKLSRLEENIGAADIEL 289


                ....*....
gi 19527294 289 ASEDMKVLD 297
Cdd:cd19078 290 TPEELREIE 298

AKR_AKR14A1_2

cd19089

AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate ...

41-266

3.77e-07

AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo. Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2). It catalyzes the conversion of 3-hydroxybutanal (3-HB) to 1,3-butanediol (1,3-BDO) by using NADPH as a cofactor.

Pssm-ID: 381315 [Multi-domain] Cd Length: 308 Bit Score: 50.72 E-value: 3.77e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  41 AIDTGFRHFDSAYLY-----QIEEEVGQAIRskiEDGTVKREDIFYTSKL-----------WSTfhRPELVRScLEKTLK 104
Cdd:cd19089  38 AFDLGITHFDLANNYgpppgSAEENFGRILK---RDLRPYRDELVISTKAgygmwpgpygdGGS--RKYLLAS-LDQSLK 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 105 NAQLDYVDLYIIHFPmalqpgDKLFPRDEHGKLLAEAVdlcdtweamekckDAGLAKSIGVSNFN---FRQLETILNKpg 181
Cdd:cd19089 112 RMGLDYVDIFYHHRY------DPDTPLEETMTALADAV-------------RSGKALYVGISNYPgakARRAIALLRE-- 170

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294 182 LKYKPVCNQVECHLyLNQS---QMLDYCKSKDIILVSYCTL---------------GSSRDKIWVDQKSPVLLDDPV--- 240
Cdd:cd19089 171 LGVPLIIHQPRYSL-LDRWaedGLLEVLEEAGIGFIAFSPLaqglltdkylngippDSRRAAESKFLTEEALTPEKLeql 249

                       250       260
                ....*....|....*....|....*...
gi 19527294 241 --LCAMANKYKQTPALIAIRYQLQRGIV 266
Cdd:cd19089 250 rkLNKIAAKRGQSLAQLALSWVLRDPRV 277

AKR_AKR10A1_2

cd19082

AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) ...

45-167

7.85e-07

AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) and Streptomyces glaucescens aldo-keto reductase (StrT) are founding members of aldo-keto reductase family 10 member A1 (AKR10A1) and A2 (AKR10A2). BlmT is bluensomycin aldo-keto reductase (AKR) and StrT is streptomycin AKR.

Pssm-ID: 381308 [Multi-domain] Cd Length: 291 Bit Score: 49.86 E-value: 7.85e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  45 GFRHFDSAYLYQI-------EEEVGQAIRSKIedgtvKREDIFYTSK-----LWSTF-HR--PELVRSCLEKTLKNAQLD 109
Cdd:cd19082  30 GGNFIDTARVYGDwvergasERVIGEWLKSRG-----NRDKVVIATKgghpdLEDMSrSRlsPEDIRADLEESLERLGTD 104

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 19527294 110 YVDLYIIHfpmalqpgdklfpRDEHGKLLAEAVDlcdtweAMEKCKDAGLAKSIGVSN 167
Cdd:cd19082 105 YIDLYFLH-------------RDDPSVPVGEIVD------TLNELVRAGKIRAFGASN 143

tas

PRK10625

putative aldo-keto reductase; Provisional

95-167

1.02e-06

putative aldo-keto reductase; Provisional

Pssm-ID: 236727 [Multi-domain] Cd Length: 346 Bit Score: 49.85 E-value: 1.02e-06

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19527294   95 VRSCLEKTLKNAQLDYVDLYIIHFPMAlqpgdklfPRDEHGKL------LAEAVDLCDTWEAMEKCKDAGLAKSIGVSN 167
Cdd:PRK10625 110 IREALHDSLKRLQTDYLDLYQVHWPQR--------PTNCFGKLgyswtdSAPAVSLLETLDALAEQQRAGKIRYIGVSN 180

AKR_AKR15A

cd19152

AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum ...

17-165

1.77e-06

AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH), and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH(EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.

Pssm-ID: 381378 [Multi-domain] Cd Length: 308 Bit Score: 48.76 E-value: 1.77e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  17 PALGFGTtVP-----DKVPKDELIKATKIAIDTGFRHFDSAYLYQI---EEEVGQAIRSKiedgtvKREDIFYTSKL-W- 86
Cdd:cd19152   1 PKLGFGT-APlgnlyEAVSDEEAKATLVAAWDLGIRYFDTAPWYGAglsEERLGAALREL------GREDYVISTKVgRl 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  87 --------STF---------HRPEL------VRSCLEKTLKNAQLDYVDLYIIHFPmalqpgDKLFPRDEHGKLLAEAVD 143
Cdd:cd19152  74 lvplqevePTFepgfwnplpFDAVFdysydgILRSIEDSLQRLGLSRIDLLSIHDP------DEDLAGAESDEHFAQAIK 147

                       170       180
                ....*....|....*....|..
gi 19527294 144 lcDTWEAMEKCKDAGLAKSIGV 165
Cdd:cd19152 148 --GAFRALEELREEGVIKAIGL 167

AKR_unchar

cd19752

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...

92-219

5.93e-06

Pssm-ID: 381391 [Multi-domain] Cd Length: 291 Bit Score: 46.94 E-value: 5.93e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  92 PELVRSCLEKTLKNAQLDYVDLYIIHfpmalqpgdKLFPRdehgkllaeaVDLCDTWEAMEKCKDAGLAKSIGVSNFNFR 171
Cdd:cd19752  94 AETIEQEIDKSLRRLGTDYIDLYYAH---------VDDRD----------TPLEETLEAFNELVKAGKVRAIGASNFAAW 154

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19527294 172 QLE---TILNKPGLKyKPVCNQVEcHLYL---------NQS----QMLDYCKS-KDIILVSYCTL 219
Cdd:cd19752 155 RLErarQIARQQGWA-EFSAIQQR-HSYLrprpgadfgVQRivtdELLDYASSrPDLTLLAYSPL 217

AKR_galDH-like

cd19153

L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ...

18-214

3.09e-05

L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).

Pssm-ID: 381379 [Multi-domain] Cd Length: 294 Bit Score: 44.83 E-value: 3.09e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  18 ALGFGTTVPDKVPKDELIKATKIAIDTGFRHFDSAYLY---QIEEEVGQAIRSKiedgTVKREDIFYTSKLW----STF- 89
Cdd:cd19153  19 TAALGGVYGDGLEQDEAVAIVAEAFAAGINHFDTSPYYgaeSSEAVLGKALAAL----QVPRSSYTVATKVGryrdSEFd 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  90 HRPELVRSCLEKTLKNAQLDYVDLYIIHfpmalqpgDKLFprdehgklLAEAVDLCDTWEAMEKCKDAGLAKSIGVSNFN 169
Cdd:cd19153  95 YSAERVRASVATSLERLHTTYLDVVYLH--------DIEF--------VDYDTLVDEALPALRTLKDEGVIKRIGIAGYP 158

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 19527294 170 FRQLETILNK--PGlkyKPVCNQVECHLYLNQSQMLD---YCKSKDIILV 214
Cdd:cd19153 159 LDTLTRATRRcsPG---SLDAVLSYCHLTLQDARLESdapGLVRGAGPHV 205

AKR_AKR6B1

cd19142

AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding ...

16-117

9.50e-05

AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding member of aldo-keto reductase family 6 member B1 (AKR6B1). Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase.

Pssm-ID: 381368 [Multi-domain] Cd Length: 325 Bit Score: 43.61 E-value: 9.50e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19527294  16 IPALGFGT------TVPDKVpKDELIKAtkiAIDTGFRHFDSAYLY---QIEEEVGQAIRSKiedgTVKREDIFYTSKL- 85
Cdd:cd19142  13 VSNVGLGTwstfstAISEEQ-AEEIVTL---AYENGINYFDTSDAFtsgQAETELGRILKKK----GWKRSSYIVSTKIy 84

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 19527294  86 WSTfhRPE---LVR----SCLEKTLKNAQLDYVDLYIIH 117
Cdd:cd19142  85 WSY--GSEergLSRkhiiESVRASLRRLQLDYIDIVIIH 121

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01