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Conserved domains on  [gi|24762418|ref|NP_611840|]
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uncharacterized protein Dmel_CG5569 [Drosophila melanogaster]

Protein Classification

Mth938-like domain-containing protein( domain architecture ID 10142263)

Mth938-like domain-containing protein similar to human NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3, an essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Mth938_2P1-like cd05125
Mth938_2P1-like domain. This model contains sequences that are similar to 2P1, a partially ...
 57-172 2.99e-51

Mth938_2P1-like domain. This model contains sequences that are similar to 2P1, a partially characterized nuclear protein, which is homologous to E3-3 from rat and known to be alternatively spliced. Its function is unknown. This family is part of the Mth938 family, for which structures, but no functional data are available.


:

Pssm-ID: 240161  Cd Length: 114  Bit Score: 160.83  E-value: 2.99e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762418  57 LMVTGYSQYGFRLNNDMVlIGPISVFPRSVLSWNVNSFEDINEDSLSLFPTLEPKIDVLIIGIGDQAPPpaLSKRIIEFM 136
Cdd:cd05125   1 NYIDAYSENGFRLNNNKV-IGSGAILPKEVFSWNVSSFEDITEESLSLFELLEPRPEILVIGTGRKSRP--LSPELRKYF 77

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 24762418 137 KKYKINVEILRTEQACATFNFLNAENRMVACALIPP 172
Cdd:cd05125  78 KKLGIAVEVVDTRNACATFNFLAEEGRRVAAALIPP 113
 
Name Accession Description Interval E-value
Mth938_2P1-like cd05125
Mth938_2P1-like domain. This model contains sequences that are similar to 2P1, a partially ...
 57-172 2.99e-51

Mth938_2P1-like domain. This model contains sequences that are similar to 2P1, a partially characterized nuclear protein, which is homologous to E3-3 from rat and known to be alternatively spliced. Its function is unknown. This family is part of the Mth938 family, for which structures, but no functional data are available.


Pssm-ID: 240161  Cd Length: 114  Bit Score: 160.83  E-value: 2.99e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762418  57 LMVTGYSQYGFRLNNDMVlIGPISVFPRSVLSWNVNSFEDINEDSLSLFPTLEPKIDVLIIGIGDQAPPpaLSKRIIEFM 136
Cdd:cd05125   1 NYIDAYSENGFRLNNNKV-IGSGAILPKEVFSWNVSSFEDITEESLSLFELLEPRPEILVIGTGRKSRP--LSPELRKYF 77

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 24762418 137 KKYKINVEILRTEQACATFNFLNAENRMVACALIPP 172
Cdd:cd05125  78 KKLGIAVEVVDTRNACATFNFLAEEGRRVAAALIPP 113
DUF498 pfam04430
Protein of unknown function (DUF498/DUF598); This is a large family of uncharacterized ...
 59-170 4.15e-36

Protein of unknown function (DUF498/DUF598); This is a large family of uncharacterized proteins found in all domains of life. The structure shows a novel fold with three beta sheets. A dimeric form is found in the crystal structure. It was suggested that the cleft in between the two monomers might bing nucleic acid.


Pssm-ID: 461305  Cd Length: 106  Bit Score: 121.86  E-value: 4.15e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762418    59 VTGYSQYGFRLNnDMVLIGPISVFPRSVLSWNVNSFEDINEDSLSLFPTlepKIDVLIIGIGDQAPPPalSKRIIEFMKK 138
Cdd:pfam04430   1 IDGYGFGGFRVN-GVRYRGSLLVLPGGVFAWDVTKGEDLTPEDLALLLA---DPEVLIIGTGARVLFL--PPELREALRK 74

                          90       100       110
                  ....*....|....*....|....*....|..
gi 24762418   139 YKINVEILRTEQACATFNFLNAENRMVACALI 170
Cdd:pfam04430  75 RGIGVEVMDTRAACRTYNVLASEGRRVAAALI 106
 
Name Accession Description Interval E-value
Mth938_2P1-like cd05125
Mth938_2P1-like domain. This model contains sequences that are similar to 2P1, a partially ...
 57-172 2.99e-51

Mth938_2P1-like domain. This model contains sequences that are similar to 2P1, a partially characterized nuclear protein, which is homologous to E3-3 from rat and known to be alternatively spliced. Its function is unknown. This family is part of the Mth938 family, for which structures, but no functional data are available.


Pssm-ID: 240161  Cd Length: 114  Bit Score: 160.83  E-value: 2.99e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762418  57 LMVTGYSQYGFRLNNDMVlIGPISVFPRSVLSWNVNSFEDINEDSLSLFPTLEPKIDVLIIGIGDQAPPpaLSKRIIEFM 136
Cdd:cd05125   1 NYIDAYSENGFRLNNNKV-IGSGAILPKEVFSWNVSSFEDITEESLSLFELLEPRPEILVIGTGRKSRP--LSPELRKYF 77

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 24762418 137 KKYKINVEILRTEQACATFNFLNAENRMVACALIPP 172
Cdd:cd05125  78 KKLGIAVEVVDTRNACATFNFLAEEGRRVAAALIPP 113
DUF498 pfam04430
Protein of unknown function (DUF498/DUF598); This is a large family of uncharacterized ...
 59-170 4.15e-36

Protein of unknown function (DUF498/DUF598); This is a large family of uncharacterized proteins found in all domains of life. The structure shows a novel fold with three beta sheets. A dimeric form is found in the crystal structure. It was suggested that the cleft in between the two monomers might bing nucleic acid.


Pssm-ID: 461305  Cd Length: 106  Bit Score: 121.86  E-value: 4.15e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762418    59 VTGYSQYGFRLNnDMVLIGPISVFPRSVLSWNVNSFEDINEDSLSLFPTlepKIDVLIIGIGDQAPPPalSKRIIEFMKK 138
Cdd:pfam04430   1 IDGYGFGGFRVN-GVRYRGSLLVLPGGVFAWDVTKGEDLTPEDLALLLA---DPEVLIIGTGARVLFL--PPELREALRK 74

                          90       100       110
                  ....*....|....*....|....*....|..
gi 24762418   139 YKINVEILRTEQACATFNFLNAENRMVACALI 170
Cdd:pfam04430  75 RGIGVEVMDTRAACRTYNVLASEGRRVAAALI 106
Mth938-like cd00248
Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and ...
 59-170 2.37e-24

Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a dimer, although it is monomeric in solution, with one disulfide bond in each monomer. 2P1 is a partially characterized nuclear protein which is homologous to E3-3 from rat and known to be alternately spliced. Xcr35 and Rpa2829 are hypothetical proteins of unknown function from the Xanthomonas campestris and Rhodopseudomonas palustris genomes, respectively, for which the crystal structures have been determined.


Pssm-ID: 238152  Cd Length: 109  Bit Score: 91.92  E-value: 2.37e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762418  59 VTGYSQYGFRLNNdMVLIGPISVFPRSVLSWNVNSFEDINEDSLSLFPTLEpKIDVLIIGIG-DQAPPPalsKRIIEFMK 137
Cdd:cd00248   2 IDGYGPGGFRIAG-QVYRGPLLVLPDGVVPWDGTSLSDLDPEALLPLLAED-RPDILLIGTGaEIAFLP---RALRAALR 76

                        90       100       110
                ....*....|....*....|....*....|...
gi 24762418 138 KYKINVEILRTEQACATFNFLNAENRMVACALI 170
Cdd:cd00248  77 AAGIGVEVMSTGAACRTYNVLLSEGRRVAAALI 109
Xcc1710_like cd05560
Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from ...
 59-170 4.30e-11

Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. Their three-dimensional structures have been determined, but their functions are unknown.


Pssm-ID: 240187  Cd Length: 109  Bit Score: 57.21  E-value: 4.30e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762418  59 VTGYSQYGFRLNnDMVLIGPISVFPRSVL-SWNVNSFEDINEDSLSLFPTLEPkiDVLIIGIGDQA--PPPALSKRIIEf 135
Cdd:cd05560   2 ITAYGDGYVEIN-DQRYEHSLIVTPDELItDWPVARFEDLTAAHFEALLALQP--EVILLGTGERQrfPPPALLAPLLA- 77

                        90       100       110
                ....*....|....*....|....*....|....*
gi 24762418 136 mkkYKINVEILRTEQACATFNFLNAENRMVACALI 170
Cdd:cd05560  78 ---RGIGVEVMDTQAACRTYNILMGEGRRVVAALL 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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