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Conserved domains on  [gi|21070967|ref|NP_620072|]
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neurexin-1 isoform beta1 [Homo sapiens]

Protein Classification

LamG and 4.1m domain-containing protein( domain architecture ID 11129565)

protein containing domains LamG, Syndecan, and 4.1m

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 121-239 1.78e-24

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 97.88  E-value: 1.78e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070967   121 FSTVQKEAVLVrvDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIE 200
Cdd:pfam02210   1 FRTRQPNGLLL--YAGGGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 21070967   201 RYPAGRQLtIFNSQATIIIGG---------KEQGQPFQGQLSGLYYNG 239
Cdd:pfam02210  79 SLPPGESL-LLNLNGPLYLGGlppllllpaLPVRAGFVGCIRDVRVNG 125
4.1m smart00294
putative band 4.1 homologues' binding motif;
387-405 1.05e-05

putative band 4.1 homologues' binding motif;


:

Pssm-ID: 128590  Cd Length: 19  Bit Score: 41.74  E-value: 1.05e-05
                           10
                   ....*....|....*....
gi 21070967    387 MYKYRNRDEGSYHVDESRN 405
Cdd:smart00294   1 MYRYKHRDEGSYHTHEPKG 19
Syndecan super family cl20212
Syndecan domain; Syndecans are transmembrane heparin sulfate proteoglycans which are ...
 367-402 5.11e-03

Syndecan domain; Syndecans are transmembrane heparin sulfate proteoglycans which are implicated in the binding of extracellular matrix components and growth factors.


The actual alignment was detected with superfamily member pfam01034:

Pssm-ID: 460035  Cd Length: 63  Bit Score: 35.45  E-value: 5.11e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 21070967   367 GMVVGIVAAAALCILILLYAMYKYRNRDEGSYHVDE 402
Cdd:pfam01034  11 AVIGGGVVGLLFAVLLVMFLVYRMKKKDEGSYALDE 46
 
Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 121-239 1.78e-24

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 97.88  E-value: 1.78e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070967   121 FSTVQKEAVLVrvDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIE 200
Cdd:pfam02210   1 FRTRQPNGLLL--YAGGGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 21070967   201 RYPAGRQLtIFNSQATIIIGG---------KEQGQPFQGQLSGLYYNG 239
Cdd:pfam02210  79 SLPPGESL-LLNLNGPLYLGGlppllllpaLPVRAGFVGCIRDVRVNG 125
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 90-238 2.24e-23

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 95.56  E-value: 2.24e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070967  90 TYIFSkGGGQITYKWPPNDRPSTRadrLAIGFSTVQKEAVLVRVDSSSGlGDYLELHIHQGKIGVKFNVGTDDIAIEeSN 169
Cdd:cd00110   1 GVSFS-GSSYVRLPTLPAPRTRLS---ISFSFRTTSPNGLLLYAGSQNG-GDFLALELEDGRLVLRYDLGSGSLVLS-SK 74

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21070967 170 AIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGRQLtIFNSQATIIIGGKEQG---------QPFQGQLSGLYYN 238
Cdd:cd00110  75 TPLNDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSA-LLNLDGPLYLGGLPEDlkspglpvsPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
116-239 5.09e-23

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 93.94  E-value: 5.09e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070967    116 RLAIGFSTVQKEAVLVRVDSSSGlGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVD- 194
Cdd:smart00282   1 SISFSFRTTSPNGLLLYAGSKGG-GDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDg 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 21070967    195 SWPVIERYPAGrqLTIFNSQATIIIGG---------KEQGQPFQGQLSGLYYNG 239
Cdd:smart00282  80 GNRVSGESPGG--LTILNLDGPLYLGGlpedlklppLPVTPGFRGCIRNLKVNG 131
4.1m smart00294
putative band 4.1 homologues' binding motif;
387-405 1.05e-05

putative band 4.1 homologues' binding motif;


Pssm-ID: 128590  Cd Length: 19  Bit Score: 41.74  E-value: 1.05e-05
                           10
                   ....*....|....*....
gi 21070967    387 MYKYRNRDEGSYHVDESRN 405
Cdd:smart00294   1 MYRYKHRDEGSYHTHEPKG 19
Syndecan pfam01034
Syndecan domain; Syndecans are transmembrane heparin sulfate proteoglycans which are ...
 367-402 5.11e-03

Syndecan domain; Syndecans are transmembrane heparin sulfate proteoglycans which are implicated in the binding of extracellular matrix components and growth factors.


Pssm-ID: 460035  Cd Length: 63  Bit Score: 35.45  E-value: 5.11e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 21070967   367 GMVVGIVAAAALCILILLYAMYKYRNRDEGSYHVDE 402
Cdd:pfam01034  11 AVIGGGVVGLLFAVLLVMFLVYRMKKKDEGSYALDE 46
 
Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 121-239 1.78e-24

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 97.88  E-value: 1.78e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070967   121 FSTVQKEAVLVrvDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIE 200
Cdd:pfam02210   1 FRTRQPNGLLL--YAGGGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 21070967   201 RYPAGRQLtIFNSQATIIIGG---------KEQGQPFQGQLSGLYYNG 239
Cdd:pfam02210  79 SLPPGESL-LLNLNGPLYLGGlppllllpaLPVRAGFVGCIRDVRVNG 125
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 90-238 2.24e-23

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 95.56  E-value: 2.24e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070967  90 TYIFSkGGGQITYKWPPNDRPSTRadrLAIGFSTVQKEAVLVRVDSSSGlGDYLELHIHQGKIGVKFNVGTDDIAIEeSN 169
Cdd:cd00110   1 GVSFS-GSSYVRLPTLPAPRTRLS---ISFSFRTTSPNGLLLYAGSQNG-GDFLALELEDGRLVLRYDLGSGSLVLS-SK 74

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21070967 170 AIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGRQLtIFNSQATIIIGGKEQG---------QPFQGQLSGLYYN 238
Cdd:cd00110  75 TPLNDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSA-LLNLDGPLYLGGLPEDlkspglpvsPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
116-239 5.09e-23

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 93.94  E-value: 5.09e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070967    116 RLAIGFSTVQKEAVLVRVDSSSGlGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVD- 194
Cdd:smart00282   1 SISFSFRTTSPNGLLLYAGSKGG-GDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDg 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 21070967    195 SWPVIERYPAGrqLTIFNSQATIIIGG---------KEQGQPFQGQLSGLYYNG 239
Cdd:smart00282  80 GNRVSGESPGG--LTILNLDGPLYLGGlpedlklppLPVTPGFRGCIRNLKVNG 131
Laminin_G_1 pfam00054
Laminin G domain;
121-194 1.36e-06

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 47.31  E-value: 1.36e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21070967   121 FSTVQKEAVLVRVDSSSGlGDYLELHIHQGKIGVKFNVGTDDiAIEESNAIINDGKYHVVRFTRSGGNATLQVD 194
Cdd:pfam00054   1 FRTTEPSGLLLYNGTQTE-RDFLALELRDGRLEVSYDLGSGA-AVVRSGDKLNDGKWHSVELERNGRSGTLSVD 72
4.1m smart00294
putative band 4.1 homologues' binding motif;
387-405 1.05e-05

putative band 4.1 homologues' binding motif;


Pssm-ID: 128590  Cd Length: 19  Bit Score: 41.74  E-value: 1.05e-05
                           10
                   ....*....|....*....
gi 21070967    387 MYKYRNRDEGSYHVDESRN 405
Cdd:smart00294   1 MYRYKHRDEGSYHTHEPKG 19
Syndecan pfam01034
Syndecan domain; Syndecans are transmembrane heparin sulfate proteoglycans which are ...
 367-402 5.11e-03

Syndecan domain; Syndecans are transmembrane heparin sulfate proteoglycans which are implicated in the binding of extracellular matrix components and growth factors.


Pssm-ID: 460035  Cd Length: 63  Bit Score: 35.45  E-value: 5.11e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 21070967   367 GMVVGIVAAAALCILILLYAMYKYRNRDEGSYHVDE 402
Cdd:pfam01034  11 AVIGGGVVGLLFAVLLVMFLVYRMKKKDEGSYALDE 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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