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Conserved domains on  [gi|24584758|ref|NP_652578|]
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uncharacterized protein Dmel_CG6115, isoform A [Drosophila melanogaster]

Protein Classification

LYR motif-containing protein( domain architecture ID 14448812)

LYR motif-containing protein similar to human electron transfer flavoprotein regulatory factor 1 (ETFRF1) that acts as a regulator of the electron transfer flavoprotein by promoting the removal of flavin from the ETF holoenzyme

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Complex1_LYR_ETFRF1_LYRM5 cd20265
LYR (leucine-tyrosine-arginine) motif found in electron transfer flavoprotein regulatory ...
 5-80 2.94e-29

LYR (leucine-tyrosine-arginine) motif found in electron transfer flavoprotein regulatory factor 1 (ETFRF1) and similar proteins; ETFRF1, also called LYR motif-containing protein 5 (LYRM5), or Ghiso (growth-factor inducible soluble) factor, acts as a regulator of the electron transfer flavoprotein by promoting the removal of flavin from the ETF holoenzyme (composed of ETFA and ETFB). It belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


:

Pssm-ID: 380760  Cd Length: 74  Bit Score: 99.19  E-value: 2.94e-29
                       10        20        30        40        50        60        70
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24584758  5 RSKVISLYKHLQYLGREYPGlnGPQKFRKQIHDAFMNHKDEQDPKKIVALLAQGRYLAKEVEALYSLKKYRSVKQR 80
Cdd:cd20265  1 RSRVRQLYKRLLYLGRDYPG--GLDYFRDRLKRAFMKNKDLTDPEEIKKAIARGEYVIKELEALYSLRKYRALKKR 74
 
Name Accession Description Interval E-value
Complex1_LYR_ETFRF1_LYRM5 cd20265
LYR (leucine-tyrosine-arginine) motif found in electron transfer flavoprotein regulatory ...
 5-80 2.94e-29

LYR (leucine-tyrosine-arginine) motif found in electron transfer flavoprotein regulatory factor 1 (ETFRF1) and similar proteins; ETFRF1, also called LYR motif-containing protein 5 (LYRM5), or Ghiso (growth-factor inducible soluble) factor, acts as a regulator of the electron transfer flavoprotein by promoting the removal of flavin from the ETF holoenzyme (composed of ETFA and ETFB). It belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


Pssm-ID: 380760  Cd Length: 74  Bit Score: 99.19  E-value: 2.94e-29
                       10        20        30        40        50        60        70
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24584758  5 RSKVISLYKHLQYLGREYPGlnGPQKFRKQIHDAFMNHKDEQDPKKIVALLAQGRYLAKEVEALYSLKKYRSVKQR 80
Cdd:cd20265  1 RSRVRQLYKRLLYLGRDYPG--GLDYFRDRLKRAFMKNKDLTDPEEIKKAIARGEYVIKELEALYSLRKYRALKKR 74
Complex1_LYR pfam05347
Complex 1 protein (LYR family); Proteins in this family include an accessory subunit of the ...
 7-59 5.18e-10

Complex 1 protein (LYR family); Proteins in this family include an accessory subunit of the higher eukaryotic NADH dehydrogenase complex. In Saccharomyces cerevisiae, the Isd11 protein has been shown to play a role in Fe/S cluster biogenesis in mitochondria. We have named this family LYR after a highly conserved tripeptide motif close to the N-terminus of these proteins.


Pssm-ID: 428432  Cd Length: 59  Bit Score: 49.88  E-value: 5.18e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 24584758    7 KVISLYKHLQYLGREYPGLNGPQKFRKQIHDAFMNHKDEQDPKKIVALLAQGR 59
Cdd:pfam05347  2 QVLSLYRALLRAARKFPDYNFREYFRRRIRDEFRKNKDLTDPEKIEKLLKEGK 54
 
Name Accession Description Interval E-value
Complex1_LYR_ETFRF1_LYRM5 cd20265
LYR (leucine-tyrosine-arginine) motif found in electron transfer flavoprotein regulatory ...
 5-80 2.94e-29

LYR (leucine-tyrosine-arginine) motif found in electron transfer flavoprotein regulatory factor 1 (ETFRF1) and similar proteins; ETFRF1, also called LYR motif-containing protein 5 (LYRM5), or Ghiso (growth-factor inducible soluble) factor, acts as a regulator of the electron transfer flavoprotein by promoting the removal of flavin from the ETF holoenzyme (composed of ETFA and ETFB). It belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


Pssm-ID: 380760  Cd Length: 74  Bit Score: 99.19  E-value: 2.94e-29
                       10        20        30        40        50        60        70
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24584758  5 RSKVISLYKHLQYLGREYPGlnGPQKFRKQIHDAFMNHKDEQDPKKIVALLAQGRYLAKEVEALYSLKKYRSVKQR 80
Cdd:cd20265  1 RSRVRQLYKRLLYLGRDYPG--GLDYFRDRLKRAFMKNKDLTDPEEIKKAIARGEYVIKELEALYSLRKYRALKKR 74
Complex1_LYR pfam05347
Complex 1 protein (LYR family); Proteins in this family include an accessory subunit of the ...
 7-59 5.18e-10

Complex 1 protein (LYR family); Proteins in this family include an accessory subunit of the higher eukaryotic NADH dehydrogenase complex. In Saccharomyces cerevisiae, the Isd11 protein has been shown to play a role in Fe/S cluster biogenesis in mitochondria. We have named this family LYR after a highly conserved tripeptide motif close to the N-terminus of these proteins.


Pssm-ID: 428432  Cd Length: 59  Bit Score: 49.88  E-value: 5.18e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 24584758    7 KVISLYKHLQYLGREYPGLNGPQKFRKQIHDAFMNHKDEQDPKKIVALLAQGR 59
Cdd:pfam05347  2 QVLSLYRALLRAARKFPDYNFREYFRRRIRDEFRKNKDLTDPEKIEKLLKEGK 54
Complex1_LYR_2 pfam13233
Complex1_LYR-like; This is a family of proteins carrying the LYR motif of family Complex1_LYR, ...
 8-78 1.77e-07

Complex1_LYR-like; This is a family of proteins carrying the LYR motif of family Complex1_LYR, pfam05347, likely to be involved in Fe-S cluster biogenesis in mitochondria.


Pssm-ID: 463812  Cd Length: 79  Bit Score: 44.26  E-value: 1.77e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24584758    8 VISLYKHLQYLGREYPgLNGPQKFRKQIHDAFMNHKDEQDPKKIVALLAQGRYLAKEVEALYSLKKYRSVK 78
Cdd:pfam13233  1 VLSLYRALLRELRELP-PNGRSYGRQYLRAEFRRHKHLTDPEEIAEFLKSWREYKELLERYNPMTEEERVR 70
Complex1_LYR_SF cd20251
LYR (leucine-tyrosine-arginine) motif found in Complex1_LYR-like superfamily; The ...
 8-59 1.83e-04

LYR (leucine-tyrosine-arginine) motif found in Complex1_LYR-like superfamily; The Complex1_LYR-like superfamily consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus. The human genome has at least ten LYR proteins that were predominantly identified as mitochondrial proteins. Some family members were also found in the cytosol or nucleus. LYR motif-containing protein 4 (LYRM4) represents the only LYR protein that is directly involved in the first steps of Fe-S cluster generation. Other LYR proteins have been identified as accessory subunits or assembly factors of mitochondrial OXPHOS (oxidative phosphorylation) complexes I, II, III and V, and they play specific roles in acetate metabolism.


Pssm-ID: 380755  Cd Length: 57  Bit Score: 35.98  E-value: 1.83e-04
                       10        20        30        40        50
               ....*....|....*....|....*....|....*....|....*....|..
gi 24584758  8 VISLYKHLQYLGREYPGLNGPQKFRKQIHDAFMNHKDEQDPKKIVALLAQGR 59
Cdd:cd20251  1 VLKLYRDLLRLARKGLPSRKRDALRQRIREEFRKNKNETDPEKIEELLAEAR 52
Complex1_LYR_LYRM7 cd20267
LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 7 (LYRM7) and ...
 32-73 1.11e-03

LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 7 (LYRM7) and similar proteins; LYRM7 is an assembly factor required for Rieske iron sulfur (Fe-S) protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. It functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane. LYRM7 mutations cause a multifocal cavitating leukoencephalopathy with a distinct and recognizable magnetic resonance imaging (MRI) pattern. LYRM7 belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


Pssm-ID: 380762  Cd Length: 72  Bit Score: 34.08  E-value: 1.11e-03
                       10        20        30        40
               ....*....|....*....|....*....|....*....|..
gi 24584758 32 RKQIHDAFMNHKDEQDPKKIVALLAQGRylakevEALYSLKK 73
Cdd:cd20267 27 RQKIREEFEKNRNETDPEKIAELLKEAR------EAAEFLRK 62
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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