The BEN domain is found in diverse animal proteins; Proteins containing BEN domains are BANP/SMAR1, NAC1 and the Drosophila mod(mdg4) isoform C, the chordopoxvirus virosomal protein E5R and several proteins of polydnaviruses. Computational analysis suggests that the BEN domain mediates protein-DNA and protein-protein interactions during chromatin organisation and transcription.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21389533    373 KVLLRRLLATFFDRNTLANSCGTGIRSSTSDPSRKPLDSRVLNAVKLYCQNFAPSFKESEMN-VIAADMCTNARRVRKR 450
Cdd:smart01025   1 SLFARYLLRVLFPRETLANSSVTGKRSRTGGSGKKPLDPNKVQAIREYLEERFPSVDLDEDWkVCIQAINNKCRRLRRR 79

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21389533    20 LNEQRLLGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGN----SKSAFELPGsVPPACFQQILSFCYTGRLtMTAS 95
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQesesSVSEITLDD-VSPEDFEALLEFMYTGKL-ISEE 78

                          90       100
                  ....*....|....*....|....*
gi 21389533    96 EQLVVMYTAGFLQIQHIVERGTDLM 120
Cdd:pfam00651  79 NVDDLLAAADKLQIPSLVDKCEEFL 103

The BEN domain is found in diverse animal proteins; Proteins containing BEN domains are BANP/SMAR1, NAC1 and the Drosophila mod(mdg4) isoform C, the chordopoxvirus virosomal protein E5R and several proteins of polydnaviruses. Computational analysis suggests that the BEN domain mediates protein-DNA and protein-protein interactions during chromatin organisation and transcription.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21389533    373 KVLLRRLLATFFDRNTLANSCGTGIRSSTSDPSRKPLDSRVLNAVKLYCQNFAPSFKESEMN-VIAADMCTNARRVRKR 450
Cdd:smart01025   1 SLFARYLLRVLFPRETLANSSVTGKRSRTGGSGKKPLDPNKVQAIREYLEERFPSVDLDEDWkVCIQAINNKCRRLRRR 79

kelch-like protein; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21389533   25 LLGLYCDVSIVVK--GQAFKAHRAVLAASSLYFRDLFSGNSKS-AFELPGSVPPacFQQILSFCYTGRLTMTASEQLVVM 101
Cdd:PHA03098   5 ELQKFCDESIIIVngGGIIKVHKIILSSSSEYFKKMFKNNFKEnEINLNIDYDS--FNEVIKYIYTGKINITSNNVKDIL 82

                         90       100
                 ....*....|....*....|..
gi 21389533  102 YTAGFLQIQHIVERGTDLMFKV 123
Cdd:PHA03098  83 SIANYLIIDFLINLCINYIIKI 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21389533   3 QMLHIEIPNFGNTVLGCLNEQRLLGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSKSAFELPGSVPPACFQQIL 82
Cdd:cd18290   1 QTLQMEIPNFGNSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSSRSAVVELPAAVQPQSFQQIL 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 21389533  83 SFCYTGRLTMTASEQLVVMYTAGFLQIQHIVERGTDLMFKVSS 125
Cdd:cd18290  81 SFCYTGRLSMNVGDQFLLMYTAGFLQIQEIMEKGTEFFLKVSS 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21389533   5 LHIEIPNFGNTVLGCLNEQRLLGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSKSAFELPGSVPPACFQQILSF 84
Cdd:cd18227   1 FRVEFPDFSSTILQKLNQQRQQGQLCDISVVVQGHLFRAHKAVLAASSPYFCDQVLLKNSRRIVLPDVMNPRVFENILLS 80

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 21389533  85 CYTGRLTMTASEQLVVMYTAGFLQIQHIVERGTDLM 120
Cdd:cd18227  81 CYTGRLVLPAPEIVSYLTAASFLQMWHVVDKCTELL 116

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21389533    20 LNEQRLLGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGN----SKSAFELPGsVPPACFQQILSFCYTGRLtMTAS 95
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQesesSVSEITLDD-VSPEDFEALLEFMYTGKL-ISEE 78

                          90       100
                  ....*....|....*....|....*
gi 21389533    96 EQLVVMYTAGFLQIQHIVERGTDLM 120
Cdd:pfam00651  79 NVDDLLAAADKLQIPSLVDKCEEFL 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21389533  29 YCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSKSA----FELPGsVPPACFQQILSFCYTGRLTMTASEQLVVMYTA 104
Cdd:cd18186   1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESssseIELDD-VSPEAFEALLDYIYTGELELSEENVEELLAAA 79

                ...
gi 21389533 105 GFL 107
Cdd:cd18186  80 DKL 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21389533   7 IEIPNFGNTVLGCLNEQRLLGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFS----GNSKSAFELpGSVPPACFQQIL 82
Cdd:cd18198   3 IPFPDHSSEILSGLNEQRTQGLLCDVVILVQGREYRTHRSVLAACSQYFKKLFTsgavVDQQNVYEI-DFVSPEALTALL 81

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 21389533  83 SFCYTGRLTMTASEQLVVMYTAGFLQIQHIVERGTDLM 120
Cdd:cd18198  82 EFAYTATLTVSTANVGDILSAARLLEIPCVSHVCAEIL 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21389533  14 NTVLGCLNEQRLLGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGN----SKSAFELPgSVPPACFQQILSFCYTGR 89
Cdd:cd18223   3 DTVLSCLNEQRIQGILCDVTIVVEDTKFKAHKNVLAASSLYFKNAFSSQeiwiSSHVLELP-DLKAEVFAEILNFIYSSK 81

                        90
                ....*....|....*.
gi 21389533  90 LTMTASEQLVVMYTAG 105
Cdd:cd18223  82 VVVKRQETVTDLVAAG 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21389533   7 IEIPNFGNTVLGCLNEQRLLGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSKSAFELPGS----------VPPA 76
Cdd:cd18327   3 IPFPEHSSELLSCLNEQRRAGLLCDLTIKTRGLEYRTHRAVLAACSLYFRKLFTGGGGGSGDLGAGggqdvceldfVGPE 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 21389533  77 CFQQILSFCYTGRLTMTASEQLVVMYTAGFLQIQHIVERGTDLM 120
Cdd:cd18327  83 ALGALLEFAYTATLTISSSNMREVLRAARLLEIPCVADACADIL 126

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21389533  20 LNEQRLLGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSKSAFElPGSV-----PPACFQQILSFCYTGRLTMTA 94
Cdd:cd18329  12 LDEQRKQELFCDCSILVEGQVFKAHRNVLFASSGYFKMLLSQNAKETGQ-PTVAtfdvfSPDTFTIILDFVYSGKLSLTS 90

                        90
                ....*....|....*....
gi 21389533  95 SEQLVVMYTAGFLQIQHIV 113
Cdd:cd18329  91 QNVIEVMSAASYLQMTDVI 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21389533  16 VLGCLNEQRLLGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSG---NSKSAFELPGSVPPACFQQILSFCYTGRLTM 92
Cdd:cd18215   6 VLLNLNRLRSRDILTDVVLVVGREQFRAHKTVLMACSGLFYSIFTDqlkNNVSVINLDPEIEPEGFRILLDFMYTSRLNL 85

                        90       100
                ....*....|....*....|..
gi 21389533  93 TASEQLVVMYTAGFLQIQHIVE 114
Cdd:cd18215  86 REGNIMAVMATAMYLQMEHVVD 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21389533  12 FGNTVLGCLNEQRLLGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSKSAFELPGSVPPACFQQILSFCYTGRLT 91
Cdd:cd18200   1 YSSALLETLNKHRLEGKFCDLSVHVQGRVFRAHKAVLAASSPYFHDKLLLNDTNCLVLPSVIEAAAFENLLQLIYSGRLT 80

                        90       100
                ....*....|....*....|....*....
gi 21389533  92 MTASEQLVVMYTAGFLQIQHIVERGTDLM 120
Cdd:cd18200  81 LCMDALPSHLLVASGLQMWQVVDRCSELL 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21389533  15 TVLGCLNEQRLLGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSG----NSKSAFELPGsVPPACFQQILSFCYTGRL 90
Cdd:cd18256   6 LILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGgmseSSKDVVQIHG-VEPDIFHILLDFIYTGVV 84

                        90       100
                ....*....|....*....|....
gi 21389533  91 TMTASEQLVVMYTAGFLQIQHIVE 114
Cdd:cd18256  85 EVTVSNVQELLVAADMLQLTEVVE 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21389533  14 NTVLGCLNEQRLLGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFS----GNSKSAFELPGsVPPACFQQILSFCYTGR 89
Cdd:cd18306   3 ESVLAKLNALRKNRQFCDVILQVGGHEIPAHRAVLACASPYLFELFSsdsdGESILTVKLDG-LDPDAVEVLVNYAYTSR 81

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 21389533  90 LTMTASEQLVVMYTAGFLQIQHIVERGTDLMFKVSSPH 127
Cdd:cd18306  82 LEVPADLVKSVYSAAKKLKMDRVKKACGDFLLEKLTPQ 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21389533  16 VLGCLNEQRLLGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSKS--AFELPGSVPPACFQQILSFCYTGRLTMT 93
Cdd:cd18278  18 ILLCLNDQRKQDILCDVTLIVEGKEFRAHRAVLAACSEYFLQALVGQTENdlVVSLPEEVTARGFGPLLQFAYTAKLLLS 97

                        90
                ....*....|....*....
gi 21389533  94 ASEQLVVMYTAGFLQIQHI 112
Cdd:cd18278  98 RENIQEVIRCAEFLRMHNL 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21389533  12 FGNTVLGCLNEQRLLGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGN---SKSAFELPGSVPPACFQQILSFCYTG 88
Cdd:cd18247   2 LPSSGFPVMEEIRRQGKLCDVTLKVGDQKFSAHRIVLAATIPYFHAMFTHDmveSKQDEITMQGIEPSALEALINFAYSG 81

                        90       100       110
                ....*....|....*....|....*....|..
gi 21389533  89 RLTMTASEQLVVMYTAGFLQIQHIVERGTDLM 120
Cdd:cd18247  82 RIAIDTSNVQSLLVGASFLQLQSVKDACCEFL 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21389533  13 GNTVLGCLNEQRLLGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSG----NSKSAFELPGsVPPACFQQILSFCYTG 88
Cdd:cd18255   2 SVTLLQGLNALRAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFTGgmreSSQDEIELKG-VSAKGLKHILDFAYTS 80

                        90       100
                ....*....|....*....|....*.
gi 21389533  89 RLTMTASEQLVVMYTAGFLQIQHIVE 114
Cdd:cd18255  81 ELTLDLDCIQDVLGAAVHLQMLPVVE 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21389533   9 IPNFGNTVLGCLNEQRLLGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSKSAFElPGSVPPACFQQILSFCYTG 88
Cdd:cd18333   1 VPSHSRQLLLQLNTQRTKGFLCDVIIVVQNALFRAHKNILAASSVYLKSLVVHDNLINLD-HEMVSPGIFRLILDYIYTG 79

                        90       100
                ....*....|....*....|....*....
gi 21389533  89 RLT--MTASEQLV--VMYTAGFLQIQHIV 113
Cdd:cd18333  80 RLSegDPGSEQNLgaVLAAASYLQIPDLV 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21389533  20 LNEQRLLGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSKSAFEL-PGSVPPACFQQILSFCYTGRLTMTASEQL 98
Cdd:cd18217   9 LNKQREAGFLCDCTIVIGQFQFKAHRNVLAAFSEYFGAQYKDTEDNIVFLdQSQVSADGFQKLLEFIYTGNLNLDSWNVA 88

                        90
                ....*....|....*..
gi 21389533  99 VVMYTAGFLQIQHIVER 115
Cdd:cd18217  89 EIHQAASYLGMEEVVAK 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21389533  14 NTVLGCLNEQRLLGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGN---SKSAFELPGSVPPAcFQQILSFCYTGRL 90
Cdd:cd18212   8 DTVLTNFEEQRKKDFLCDITLIVENVQFRAHKALLAASSEYFSMMFADEgevGQSIYMLEGMVAET-FGALLEFIYTGCL 86

                        90       100
                ....*....|....*....|....*....
gi 21389533  91 TMTASEQLVVMYTAGFLQIQHIVERGTDL 119
Cdd:cd18212  87 QVGEKSLEQILATAQFLKVNDLVKAYSDY 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21389533   9 IPNFGNTVLGCLNEQRLLGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSKSAFElPGSVPPACFQQILSFCYTG 88
Cdd:cd18334   1 LPNHAKQLLLQLNQQRAKGFLCDVIIVVENALFRAHKNILAASSMYFKSLVLHDNLINLD-TDMVNPTVFRQILDFIYTG 79

                        90       100
                ....*....|....*....|....*...
gi 21389533  89 RLTMT--ASEQ--LVVMYTAGFLQIQHI 112
Cdd:cd18334  80 KLLTSdqPGEQnfNALLTAASYLQLHDL 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21389533  16 VLGCLNEQRLLGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSKSAFELPGSVPPAcFQQILSFCYTGRLTMTAS 95
Cdd:cd18232   5 VLQALNKQREEGQYCDATLDVGGRVFKAHWSVLACCSHFFQSLYGDGTSGSVVLPESFAEV-FGLLLDFFYTGELALTRE 83

                        90
                ....*....|....*....
gi 21389533  96 EQLVVMYTAGFLQIQHIVE 114
Cdd:cd18232  84 NRDRVLLAAKELRVPEAVE 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21389533   7 IEIPNFGNTVLGCLNEQRLLGLYCDVSIVVKGQAFKAHRAVLAASSLYF----RDLFSGnSKSAFELPGS-VPPACFQQI 81
Cdd:cd18956   1 MEFPEHGGRLLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFhlfyRDRPAG-GRDTVRLNGDiVTAPAFGRL 79

                        90       100       110
                ....*....|....*....|....*....|...
gi 21389533  82 LSFCYTGRLTMTASEQLVVMYTAGFLQIQHIVE 114
Cdd:cd18956  80 LDFMYEGRLDLRSLPVEDVLAAASYLHMYDIVK 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21389533  16 VLGCLNEQRLLGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLF---SGNSKSAFELP----GSVppacfQQILSFCYTG 88
Cdd:cd18233   5 LLQQLHEQRIQGLLCDCMLVVKGVCFKAHKNVLAAFSQYFRSLFqnsSSQKNDVFHLDiknvGGI-----GQILDFMYTS 79

                        90       100
                ....*....|....*....|....*
gi 21389533  89 RLTMTASEQLVVMYTAGFLQIQHIV 113
Cdd:cd18233  80 HLDLNQDNVQVMLDIAQCLQVQNVL 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21389533   7 IEIPNFGNTVLGCLNEQRLLGLYCDVSIVVKGQAFKAHRAVLAASSLYF----------RDLFSGNSKsafelpgSVPPA 76
Cdd:cd18194   1 MEFPEHSRQLLQCLREQRSQGFLCDCTVLVGSAQFPAHRAVLASCSMYFhlfyrdrldkRDLVRLNSD-------IVTAP 73

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 21389533  77 CFQQILSFCYTGRLTMTASEQLVVMYTAGFLQIQHIVE 114
Cdd:cd18194  74 AFGLLLDFMYEGRLALRDLPVEDVLAAASYLHMYDIVK 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21389533  15 TVLGCLNEQRLLGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGN-----------------SKSAFELPGsVPPAC 77
Cdd:cd18195   4 ALLLQLNEQRLRGLFCDVTLIAGDTKFRAHRSVLAASSPYFRELLSSPlplgaaavaaapgatqsPERVLELPG-VKAGV 82

                        90
                ....*....|....*...
gi 21389533  78 FQQILSFCYTGRLTMTAS 95
Cdd:cd18195  83 FSDVLNFIYSSRVALPGS 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21389533   7 IEIPNFGNTVLGCLNEQRLLGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSK---SAFELPGSVPPACFQQILS 83
Cdd:cd18331   2 IQFTRHASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQLKcnlSVINLDPEINPEGFNILLD 81