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Conserved domains on  [gi|254675257|ref|NP_659139|]
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long palate lung and nasal epithelium protein 5 precursor [Mus musculus]

Protein Classification

LBP/BPI/CETP family protein( domain architecture ID 1919)

LBP (lipopolysaccharide-binding protein)/BPI (bactericidal permeability-increasing protein)/CETP (cholesteryl ester transfer protein) family protein similar to Mesocricetus auratus cholesteryl ester transfer protein and Equus burchellii antiquorum latherin

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BPI super family cl00188
BPI/LBP/CETP domain; Bactericidal permeability-increasing protein (BPI) / ...
 130-226 1.13e-06

BPI/LBP/CETP domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) domain; binds to and neutralizes lipopolysaccharides from the outer membrane of Gram-negative bacteria.; Apolar pockets on the concave surface bind a molecule of phosphatidylcholine, primarily by interacting with their acyl chains; this suggests that the pockets may also bind the acyl chains of lipopolysaccharide.


The actual alignment was detected with superfamily member pfam01273:

Pssm-ID: 412206  Cd Length: 164  Bit Score: 48.46  E-value: 1.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675257  130 LQITLRCKLYLSFLEILwlEAIkNIRIGVRLEQIGN-KTQVAFEECHTPPGSLNIKILKRsdtllPNQLLKLVTNTLEKS 208
Cdd:pfam01273  73 LKVSGKWPLRGSFLELV--VGV-DITASLRLERDPQgRPTLVLSDCSSSPGSISISLLGG-----LGWLLDLLTNLLEST 144

                          90
                  ....*....|....*...
gi 254675257  209 LPFLLQKIVCPVATNLIN 226
Cdd:pfam01273 145 LPKVLQSQLCPVIQSVLS 162
 
Name Accession Description Interval E-value
LBP_BPI_CETP pfam01273
LBP / BPI / CETP family, N-terminal domain; The N and C terminal domains of the LBP/BPI/CETP ...
 130-226 1.13e-06

LBP / BPI / CETP family, N-terminal domain; The N and C terminal domains of the LBP/BPI/CETP family are structurally similar.


Pssm-ID: 396022  Cd Length: 164  Bit Score: 48.46  E-value: 1.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675257  130 LQITLRCKLYLSFLEILwlEAIkNIRIGVRLEQIGN-KTQVAFEECHTPPGSLNIKILKRsdtllPNQLLKLVTNTLEKS 208
Cdd:pfam01273  73 LKVSGKWPLRGSFLELV--VGV-DITASLRLERDPQgRPTLVLSDCSSSPGSISISLLGG-----LGWLLDLLTNLLEST 144

                          90
                  ....*....|....*...
gi 254675257  209 LPFLLQKIVCPVATNLIN 226
Cdd:pfam01273 145 LPKVLQSQLCPVIQSVLS 162
BPI1 smart00328
BPI/LBP/CETP N-terminal domain; Bactericidal permeability-increasing protein (BPI) / ...
 154-231 8.20e-03

BPI/LBP/CETP N-terminal domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) N-terminal domain


Pssm-ID: 214622 [Multi-domain]  Cd Length: 225  Bit Score: 37.76  E-value: 8.20e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 254675257   154 IRIGVRLEQIGN-KTQVAFEECHTPPGSLNIKILKRSDTLLPNQLLKLVTNTLEKSLPfllqKIVCPVATNLINFLLED 231
Cdd:smart00328 106 ISADLRIESNASgRPTVTLSSCSSSIGDVRLHFSGSVLGWLINLFRKFIENTLRNVLE----DQICPVIDSAVSNKMND 180
 
Name Accession Description Interval E-value
LBP_BPI_CETP pfam01273
LBP / BPI / CETP family, N-terminal domain; The N and C terminal domains of the LBP/BPI/CETP ...
 130-226 1.13e-06

LBP / BPI / CETP family, N-terminal domain; The N and C terminal domains of the LBP/BPI/CETP family are structurally similar.


Pssm-ID: 396022  Cd Length: 164  Bit Score: 48.46  E-value: 1.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675257  130 LQITLRCKLYLSFLEILwlEAIkNIRIGVRLEQIGN-KTQVAFEECHTPPGSLNIKILKRsdtllPNQLLKLVTNTLEKS 208
Cdd:pfam01273  73 LKVSGKWPLRGSFLELV--VGV-DITASLRLERDPQgRPTLVLSDCSSSPGSISISLLGG-----LGWLLDLLTNLLEST 144

                          90
                  ....*....|....*...
gi 254675257  209 LPFLLQKIVCPVATNLIN 226
Cdd:pfam01273 145 LPKVLQSQLCPVIQSVLS 162
BPI1 smart00328
BPI/LBP/CETP N-terminal domain; Bactericidal permeability-increasing protein (BPI) / ...
 154-231 8.20e-03

BPI/LBP/CETP N-terminal domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) N-terminal domain


Pssm-ID: 214622 [Multi-domain]  Cd Length: 225  Bit Score: 37.76  E-value: 8.20e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 254675257   154 IRIGVRLEQIGN-KTQVAFEECHTPPGSLNIKILKRSDTLLPNQLLKLVTNTLEKSLPfllqKIVCPVATNLINFLLED 231
Cdd:smart00328 106 ISADLRIESNASgRPTVTLSSCSSSIGDVRLHFSGSVLGWLINLFRKFIENTLRNVLE----DQICPVIDSAVSNKMND 180
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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