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Conserved domains on  [gi|21450317|ref|NP_659168|]
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histone deacetylase 11 [Mus musculus]

Protein Classification

histone deacetylase( domain architecture ID 10177964)

class IV histone deacetylase catalyzes the hydrolysis of N(6)-acetyl-lysine residues of histones (or other proteins) to yield deacetylated proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HDAC_classIV cd09993
Histone deacetylase class IV also known as histone deacetylase 11; Class IV histone ...
 35-319 1.15e-140

Histone deacetylase class IV also known as histone deacetylase 11; Class IV histone deacetylases (HDAC11; EC 3.5.1.98) are predicted Zn-dependent enzymes. This class includes animal HDAC11, plant HDA2 and related bacterial deacetylases. Enzymes in this subfamily participate in regulation of a number of different processes through protein modification (deacetylation). They catalyze hydrolysis of N(6)-acetyl-lysine of histones (or other proteins) to yield a deacetylated proteins. Histone deacetylases often act as members of large multi-protein complexes such as mSin3A or SMRT/N-CoR. Human HDAC11 does not associate with them but can interact with HDAC6 in vivo. It has been suggested that HDAC11 and HDAC6 may use non-histone proteins as their substrates and play a role other than to directly modulate chromatin structure. In normal tissues, expression of HDAC11 is limited to kidney, heart, brain, skeletal muscle and testis, suggesting that its function might be tissue-specific. In mammals, HDAC11 proteins are known to be involved in progression of various tumors. HDAC11 plays an essential role in regulating OX40 ligand (OX40L) expression in Hodgkin lymphoma (HL); selective inhibition of HDAC11 expression significantly up-regulates OX40L and induces apoptosis in HL cell lines. Thus, inhibition of HDAC11 could be a therapeutic drug option for antitumor immune response in HL patients.


:

Pssm-ID: 212519 [Multi-domain]  Cd Length: 275  Bit Score: 399.56  E-value: 1.15e-140
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317  35 HPFDAGKWGKVINFLKEEKLLSDGMLVEAREASEEDLLVVHTRRYLNELKWSfvvATITEIPPVIFLPNFLvqrKVLRPL 114
Cdd:cd09993   1 HRFPMRKYGLLREALLEEGLVLPEDIVEPEPATREDLLRVHDPEYLESLKSG---ELSREEIRRIGFPWSP---ELVERT 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317 115 RTQTGGTIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERvEGISRATIIDLDAHQGNGHERDFMG 194
Cdd:cd09993  75 RLAVGGTILAARLALEHGLAINLAGGTHHAFPDRGEGFCVFNDIAIAARVLLAE-GLVRRVLIVDLDVHQGNGTAAIFAD 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317 195 DKRVYIMDVYNRHIYPGDrfaKEAIRRKVELEWGTEDEEYLEKVERNVRRSLQEHLPDVVVYNAGTDVLEGDRLGGLSIS 274
Cdd:cd09993 154 DPSVFTFSMHGEKNYPFR---KEPSDLDVPLPDGTGDDEYLAALEEALPRLLAEFRPDLVFYNAGVDVLAGDRLGRLSLS 230

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 21450317 275 PAGIVKRDEVVFRVVRAHDIPILMVTSGGYQKRTARIIADSILNL 319
Cdd:cd09993 231 LEGLRERDRLVLRFARARGIPVAMVLGGGYSRDIARLVARHAQTL 275
 
Name Accession Description Interval E-value
HDAC_classIV cd09993
Histone deacetylase class IV also known as histone deacetylase 11; Class IV histone ...
 35-319 1.15e-140

Histone deacetylase class IV also known as histone deacetylase 11; Class IV histone deacetylases (HDAC11; EC 3.5.1.98) are predicted Zn-dependent enzymes. This class includes animal HDAC11, plant HDA2 and related bacterial deacetylases. Enzymes in this subfamily participate in regulation of a number of different processes through protein modification (deacetylation). They catalyze hydrolysis of N(6)-acetyl-lysine of histones (or other proteins) to yield a deacetylated proteins. Histone deacetylases often act as members of large multi-protein complexes such as mSin3A or SMRT/N-CoR. Human HDAC11 does not associate with them but can interact with HDAC6 in vivo. It has been suggested that HDAC11 and HDAC6 may use non-histone proteins as their substrates and play a role other than to directly modulate chromatin structure. In normal tissues, expression of HDAC11 is limited to kidney, heart, brain, skeletal muscle and testis, suggesting that its function might be tissue-specific. In mammals, HDAC11 proteins are known to be involved in progression of various tumors. HDAC11 plays an essential role in regulating OX40 ligand (OX40L) expression in Hodgkin lymphoma (HL); selective inhibition of HDAC11 expression significantly up-regulates OX40L and induces apoptosis in HL cell lines. Thus, inhibition of HDAC11 could be a therapeutic drug option for antitumor immune response in HL patients.


Pssm-ID: 212519 [Multi-domain]  Cd Length: 275  Bit Score: 399.56  E-value: 1.15e-140
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317  35 HPFDAGKWGKVINFLKEEKLLSDGMLVEAREASEEDLLVVHTRRYLNELKWSfvvATITEIPPVIFLPNFLvqrKVLRPL 114
Cdd:cd09993   1 HRFPMRKYGLLREALLEEGLVLPEDIVEPEPATREDLLRVHDPEYLESLKSG---ELSREEIRRIGFPWSP---ELVERT 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317 115 RTQTGGTIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERvEGISRATIIDLDAHQGNGHERDFMG 194
Cdd:cd09993  75 RLAVGGTILAARLALEHGLAINLAGGTHHAFPDRGEGFCVFNDIAIAARVLLAE-GLVRRVLIVDLDVHQGNGTAAIFAD 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317 195 DKRVYIMDVYNRHIYPGDrfaKEAIRRKVELEWGTEDEEYLEKVERNVRRSLQEHLPDVVVYNAGTDVLEGDRLGGLSIS 274
Cdd:cd09993 154 DPSVFTFSMHGEKNYPFR---KEPSDLDVPLPDGTGDDEYLAALEEALPRLLAEFRPDLVFYNAGVDVLAGDRLGRLSLS 230

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 21450317 275 PAGIVKRDEVVFRVVRAHDIPILMVTSGGYQKRTARIIADSILNL 319
Cdd:cd09993 231 LEGLRERDRLVLRFARARGIPVAMVLGGGYSRDIARLVARHAQTL 275
Hist_deacetyl pfam00850
Histone deacetylase domain; Histones can be reversibly acetylated on several lysine residues. ...
 35-318 1.05e-62

Histone deacetylase domain; Histones can be reversibly acetylated on several lysine residues. Regulation of transcription is caused in part by this mechanism. Histone deacetylases catalyze the removal of the acetyl group. Histone deacetylases are related to other proteins.


Pssm-ID: 425906 [Multi-domain]  Cd Length: 298  Bit Score: 201.70  E-value: 1.05e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317    35 HPFDAGKWGKVINFLKEEKLLSDGMLVEAREASEEDLLVVHTRRYLNELKWSFVVATITEIPPVIFLPNFL-VQRKVLRP 113
Cdd:pfam00850   1 HPENPERLKAILEALREAGLLPDLEIIAPRPATEEELLLVHSPEYLEFLEEAAPEGGALLLLSYLSGDDDTpVSPGSYEA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317   114 LRTQTGGTIMAGKLAVE----RGWAINVGGGfHHCSSDRGGGFCAYADITLAIKFLFERvEGISRATIIDLDAHQGNGHE 189
Cdd:pfam00850  81 ALLAAGGTLAAADAVLSgearNAFALVRPPG-HHAERDRASGFCIFNNVAIAAKYLREK-YGLKRVAIVDFDVHHGNGTQ 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317   190 RDFMGDKRVYIMDV--YNRHIYPGDRFAKEAIRRK-------VELEWGTEDEEYLEKVERNVRRSLQEHLPDVVVYNAGT 260
Cdd:pfam00850 159 EIFYDDPSVLTLSIhqYPGGFYPGTGFADETGEGKgkgytlnVPLPPGTGDAEYLAAFEEILLPALEEFQPDLILVSAGF 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 21450317   261 DVLEGDRLGGLSISPAGIVKRDEVVFRVVRAHDIPILMVTSGGYQKRTARIIADSILN 318
Cdd:pfam00850 239 DAHAGDPLGGLNLTTEGFAEITRILLELADPLCIRVVSVLEGGYNLDALARSATAVLA 296
AcuC COG0123
Acetoin utilization deacetylase AcuC or a related deacetylase [Secondary metabolites ...
 17-304 4.53e-61

Acetoin utilization deacetylase AcuC or a related deacetylase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 439893 [Multi-domain]  Cd Length: 308  Bit Score: 197.64  E-value: 4.53e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317  17 PIVYSPRYNITFMGleKLHPFDAGKWGKVINFLKEEKLLSDGMLVEAREASEEDLLVVHTRRYLNELKwsfvvaTITEIP 96
Cdd:COG0123   2 ALIYHPDYLLHDLG--PGHPEPPERLRAILDALEASGLLDDLELVEPPPATEEDLLRVHTPDYVDALR------AASLDG 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317  97 PVIFL-PNFLVQRKVLRPLRTQTGGTIMAGKLAVERGWAI---NVGGGFHHCSSDRGGGFCAYADITLAIKFLfeRVEGI 172
Cdd:COG0123  74 GYGQLdPDTPVSPGTWEAALLAAGGALAAADAVLEGEARNafaLVRPPGHHAERDRAMGFCLFNNAAIAARYL--LAKGL 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317 173 SRATIIDLDAHQGNGHERDFMGDKRVYIMDVYNRHIYPGDRFAKEAIRRK-------VELEWGTEDEEYLEKVERNVRRS 245
Cdd:COG0123 152 ERVAIVDFDVHHGNGTQDIFYDDPDVLTISIHQDPLYPGTGAADETGEGAgegsnlnVPLPPGTGDAEYLAALEEALLPA 231

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 21450317 246 LQEHLPDVVVYNAGTDVLEGDRLGGLSISPAGIVKRDEVVFRVVRAHDIPILMVTSGGY 304
Cdd:COG0123 232 LEAFKPDLIVVSAGFDAHADDPLGRLNLTTEGYAWRTRRVLELADHCGGPVVSVLEGGY 290
PTZ00346 PTZ00346
histone deacetylase; Provisional
 69-322 9.80e-15

histone deacetylase; Provisional


Pssm-ID: 240374 [Multi-domain]  Cd Length: 429  Bit Score: 74.68  E-value: 9.80e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317   69 EDLLVVHTRRYLNEL------KWSFVVATIT-----EIPPViflpNFLVQRKVLRPLRTQTGGTIM-AGKLAVERGWain 136
Cdd:PTZ00346  77 EELMAYHTDTYLANLglhscrSWLWNAETSKvffsgDCPPV----EGLMEHSIATASGTLMGAVLLnSGQVDVAVHW--- 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317  137 vGGGFHHCSSDRGGGFCAYADITLAIkflFERVEGISRATIIDLDAHQGNGHERDFMGDKRVYIMDV--YNRHIYPGDRF 214
Cdd:PTZ00346 150 -GGGMHHSKCGECSGFCYVNDIVLGI---LELLKCHDRVLYVDIDMHHGDGVDEAFCTSDRVFTLSLhkFGESFFPGTGH 225

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317  215 AKEA-------IRRKVELEWGTEDEEYLEKVERNVRRSLQEHLPDVVVYNAGTDVLEGDRLGGLSISPAGIVKrdevVFR 287
Cdd:PTZ00346 226 PRDVgygrgryYSMNLAVWDGITDFYYLGLFEHALHSIVRRYSPDAIVLQCGADSLAGDRLGLLNLSSFGHGQ----CVQ 301

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 21450317  288 VVRAHDIPILMVTSGGYQKR-TARIIA--DSILNLHDL 322
Cdd:PTZ00346 302 AVRDLGIPMLALGGGGYTIRnVAKLWAyeTSILTGHPL 339
 
Name Accession Description Interval E-value
HDAC_classIV cd09993
Histone deacetylase class IV also known as histone deacetylase 11; Class IV histone ...
 35-319 1.15e-140

Histone deacetylase class IV also known as histone deacetylase 11; Class IV histone deacetylases (HDAC11; EC 3.5.1.98) are predicted Zn-dependent enzymes. This class includes animal HDAC11, plant HDA2 and related bacterial deacetylases. Enzymes in this subfamily participate in regulation of a number of different processes through protein modification (deacetylation). They catalyze hydrolysis of N(6)-acetyl-lysine of histones (or other proteins) to yield a deacetylated proteins. Histone deacetylases often act as members of large multi-protein complexes such as mSin3A or SMRT/N-CoR. Human HDAC11 does not associate with them but can interact with HDAC6 in vivo. It has been suggested that HDAC11 and HDAC6 may use non-histone proteins as their substrates and play a role other than to directly modulate chromatin structure. In normal tissues, expression of HDAC11 is limited to kidney, heart, brain, skeletal muscle and testis, suggesting that its function might be tissue-specific. In mammals, HDAC11 proteins are known to be involved in progression of various tumors. HDAC11 plays an essential role in regulating OX40 ligand (OX40L) expression in Hodgkin lymphoma (HL); selective inhibition of HDAC11 expression significantly up-regulates OX40L and induces apoptosis in HL cell lines. Thus, inhibition of HDAC11 could be a therapeutic drug option for antitumor immune response in HL patients.


Pssm-ID: 212519 [Multi-domain]  Cd Length: 275  Bit Score: 399.56  E-value: 1.15e-140
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317  35 HPFDAGKWGKVINFLKEEKLLSDGMLVEAREASEEDLLVVHTRRYLNELKWSfvvATITEIPPVIFLPNFLvqrKVLRPL 114
Cdd:cd09993   1 HRFPMRKYGLLREALLEEGLVLPEDIVEPEPATREDLLRVHDPEYLESLKSG---ELSREEIRRIGFPWSP---ELVERT 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317 115 RTQTGGTIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERvEGISRATIIDLDAHQGNGHERDFMG 194
Cdd:cd09993  75 RLAVGGTILAARLALEHGLAINLAGGTHHAFPDRGEGFCVFNDIAIAARVLLAE-GLVRRVLIVDLDVHQGNGTAAIFAD 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317 195 DKRVYIMDVYNRHIYPGDrfaKEAIRRKVELEWGTEDEEYLEKVERNVRRSLQEHLPDVVVYNAGTDVLEGDRLGGLSIS 274
Cdd:cd09993 154 DPSVFTFSMHGEKNYPFR---KEPSDLDVPLPDGTGDDEYLAALEEALPRLLAEFRPDLVFYNAGVDVLAGDRLGRLSLS 230

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 21450317 275 PAGIVKRDEVVFRVVRAHDIPILMVTSGGYQKRTARIIADSILNL 319
Cdd:cd09993 231 LEGLRERDRLVLRFARARGIPVAMVLGGGYSRDIARLVARHAQTL 275
HDAC cd09301
Histone deacetylase (HDAC) classes I, II, IV and related proteins; The HDAC/HDAC-like family ...
 41-319 4.25e-118

Histone deacetylase (HDAC) classes I, II, IV and related proteins; The HDAC/HDAC-like family includes Zn-dependent histone deacetylase classes I, II and IV (class III HDACs, also called sirtuins, are NAD-dependent and structurally unrelated, and therefore not part of this family). Histone deacetylases catalyze hydrolysis of N(6)-acetyl-lysine residues in histone amino termini to yield a deacetylated histone (EC 3.5.1.98), as opposed to the acetylation reaction by some histone acetyltransferases (EC 2.3.1.48). Deacetylases of this family are involved in signal transduction through histone and other protein modification, and can repress/activate transcription of a number of different genes. They usually act via the formation of large multiprotein complexes. They are involved in various cellular processes, including cell cycle regulation, DNA damage response, embryonic development, cytokine signaling important for immune response and post-translational control of the acetyl coenzyme A synthetase. In mammals, they are known to be involved in progression of different tumors. Specific inhibitors of mammalian histone deacetylases are an emerging class of promising novel anticancer drugs.


Pssm-ID: 212512 [Multi-domain]  Cd Length: 279  Bit Score: 342.49  E-value: 4.25e-118
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317  41 KWGKVINFLKEEKLLSDGMLVEAREASEEDLLVVHTRRYLNELKWSFVVATITEIPPVIFLPNFLVQRKVLRPLRTQTGG 120
Cdd:cd09301   1 RIRDLIEALKELGLRPKIELIECREATEELLLKVHTEEYLNELKANFAVATITESKPVIFGPNFPVQRHYFRGARLSTGG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317 121 TIMAGKLAV----ERGWAInVGGGFHHCSSDRGGGFCAYADITLAIKFLFERveGISRATIIDLDAHQGNGHERDFMGDK 196
Cdd:cd09301  81 VVEAAELVAkgelERAFAV-VGAGGHHAGKSRAWGFCYFNDVVLAIKFLRER--GISRILIIDTDAHHGDGTREAFYDDD 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317 197 RVYIMDVYNRHIYPGDRFAKEAIRRKVELEWGTEDEEYLEKVERNVRRSLQEHLPDVVVYNAGTDVLEGDRLGGLSISPA 276
Cdd:cd09301 158 RVLHMSFHNYDIYPFGRGKGKGYKINVPLEDGLGDEEYLDAVERVISKVLEEFEPEVVVLQFGHDTHEGDRLGGFNLSEK 237

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 21450317 277 GIVKRDEVVFRVVRahDIPILMVTSGGYQ-KRTARIIADSILNL 319
Cdd:cd09301 238 GFVKLAEIVKEFAR--GGPILMVLGGGYNpEAAARIWTAIIKEL 279
Hist_deacetyl pfam00850
Histone deacetylase domain; Histones can be reversibly acetylated on several lysine residues. ...
 35-318 1.05e-62

Histone deacetylase domain; Histones can be reversibly acetylated on several lysine residues. Regulation of transcription is caused in part by this mechanism. Histone deacetylases catalyze the removal of the acetyl group. Histone deacetylases are related to other proteins.


Pssm-ID: 425906 [Multi-domain]  Cd Length: 298  Bit Score: 201.70  E-value: 1.05e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317    35 HPFDAGKWGKVINFLKEEKLLSDGMLVEAREASEEDLLVVHTRRYLNELKWSFVVATITEIPPVIFLPNFL-VQRKVLRP 113
Cdd:pfam00850   1 HPENPERLKAILEALREAGLLPDLEIIAPRPATEEELLLVHSPEYLEFLEEAAPEGGALLLLSYLSGDDDTpVSPGSYEA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317   114 LRTQTGGTIMAGKLAVE----RGWAINVGGGfHHCSSDRGGGFCAYADITLAIKFLFERvEGISRATIIDLDAHQGNGHE 189
Cdd:pfam00850  81 ALLAAGGTLAAADAVLSgearNAFALVRPPG-HHAERDRASGFCIFNNVAIAAKYLREK-YGLKRVAIVDFDVHHGNGTQ 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317   190 RDFMGDKRVYIMDV--YNRHIYPGDRFAKEAIRRK-------VELEWGTEDEEYLEKVERNVRRSLQEHLPDVVVYNAGT 260
Cdd:pfam00850 159 EIFYDDPSVLTLSIhqYPGGFYPGTGFADETGEGKgkgytlnVPLPPGTGDAEYLAAFEEILLPALEEFQPDLILVSAGF 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 21450317   261 DVLEGDRLGGLSISPAGIVKRDEVVFRVVRAHDIPILMVTSGGYQKRTARIIADSILN 318
Cdd:pfam00850 239 DAHAGDPLGGLNLTTEGFAEITRILLELADPLCIRVVSVLEGGYNLDALARSATAVLA 296
AcuC COG0123
Acetoin utilization deacetylase AcuC or a related deacetylase [Secondary metabolites ...
 17-304 4.53e-61

Acetoin utilization deacetylase AcuC or a related deacetylase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 439893 [Multi-domain]  Cd Length: 308  Bit Score: 197.64  E-value: 4.53e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317  17 PIVYSPRYNITFMGleKLHPFDAGKWGKVINFLKEEKLLSDGMLVEAREASEEDLLVVHTRRYLNELKwsfvvaTITEIP 96
Cdd:COG0123   2 ALIYHPDYLLHDLG--PGHPEPPERLRAILDALEASGLLDDLELVEPPPATEEDLLRVHTPDYVDALR------AASLDG 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317  97 PVIFL-PNFLVQRKVLRPLRTQTGGTIMAGKLAVERGWAI---NVGGGFHHCSSDRGGGFCAYADITLAIKFLfeRVEGI 172
Cdd:COG0123  74 GYGQLdPDTPVSPGTWEAALLAAGGALAAADAVLEGEARNafaLVRPPGHHAERDRAMGFCLFNNAAIAARYL--LAKGL 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317 173 SRATIIDLDAHQGNGHERDFMGDKRVYIMDVYNRHIYPGDRFAKEAIRRK-------VELEWGTEDEEYLEKVERNVRRS 245
Cdd:COG0123 152 ERVAIVDFDVHHGNGTQDIFYDDPDVLTISIHQDPLYPGTGAADETGEGAgegsnlnVPLPPGTGDAEYLAALEEALLPA 231

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 21450317 246 LQEHLPDVVVYNAGTDVLEGDRLGGLSISPAGIVKRDEVVFRVVRAHDIPILMVTSGGY 304
Cdd:COG0123 232 LEAFKPDLIVVSAGFDAHADDPLGRLNLTTEGYAWRTRRVLELADHCGGPVVSVLEGGY 290
HDAC_AcuC_like cd09994
Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; AcuC (Acetoin ...
 18-311 1.51e-38

Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; AcuC (Acetoin utilization protein) is a class I deacetylase found only in bacteria and is involved in post-translational control of the acetyl-coenzyme A synthetase (AcsA). Deacetylase AcuC works in coordination with deacetylase SrtN (class III), possibly to maintain AcsA in active (deacetylated) form and let the cell grow under low concentration of acetate. B. subtilis AcuC is a member of operon acuABC; this operon is repressed by the presence of glucose and does not show induction by acetoin; acetoin is a bacterial fermentation product that can be converted to acetate via the butanediol cycle in absence of other carbon sources. Inactivation of AcuC leads to slower growth and lower cell yield under low-acetate conditions in Bacillus subtilis. In general, Class I histone deacetylases (HDACs) are Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine residues in histone amino termini to yield a deacetylated histone (EC 3.5.1.98). Enzymes belonging to this group participate in regulation of a number of processes through protein (mostly different histones) modification (deacetylation). Class I histone deacetylases in general act via the formation of large multiprotein complexes. Members of this class are involved in cell cycle regulation, DNA damage response, embryonic development, cytokine signaling important for immune response and in posttranslational control of the acetyl coenzyme A synthetase.


Pssm-ID: 212520 [Multi-domain]  Cd Length: 313  Bit Score: 139.23  E-value: 1.51e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317  18 IVYSPRYNITFMGleKLHPFDAGKWGKVINFLKEEKLLSDGMLVEAREASEEDLLVVHTRRYLNELKwsfvVATITEIPP 97
Cdd:cd09994   2 FIYSEEYLRYSFG--PNHPFNPPRLSLTKDLLRALGLLPPVDLVPPRPATEEELLLFHTPDYIEAVK----EASRGQEPE 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317  98 VIFL--------PNFlvqRKVLRPLRTQTGGTIMAGKLAVERGW--AINVGGGFHHCSSDRGGGFCAYADITLAIKFLFE 167
Cdd:cd09994  76 GRGRlglgtednPVF---PGMHEAAALVVGGTLLAARLVLEGEArrAFNPAGGLHHAMRGRASGFCVYNDAAVAIERLRD 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317 168 RveGISRATIIDLDAHQGNGHERDFMGDKRVYIMDV--YNRHIYPGDRFAKEAIRRK-------VELEWGTEDEEYLEKV 238
Cdd:cd09994 153 K--GGLRVAYVDIDAHHGDGVQAAFYDDPRVLTISLheSGRYLFPGTGFVDEIGEGEgygyavnIPLPPGTGDDEFLRAF 230

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21450317 239 ERNVRRSLQEHLPDVVVYNAGTDVLEGDRLGGLSISPAGIVKrdevVFRVVR--AHDI---PILMVTSGGYQKR-TARI 311
Cdd:cd09994 231 EAVVPPLLRAFRPDVIVSQHGADAHAGDPLTHLNLSNRAYRA----AVRRIRelADEYcggRWLALGGGGYNPDvVARA 305
HDAC_classI cd09991
Class I histone deacetylases; Class I histone deacetylases (HDACs) are Zn-dependent enzymes ...
 60-310 3.09e-25

Class I histone deacetylases; Class I histone deacetylases (HDACs) are Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine residues in histone amino termini to yield a deacetylated histone (EC 3.5.1.98). Enzymes belonging to this group participate in regulation of a number of processes through protein (mostly different histones) modification (deacetylation). Class I histone deacetylases in general act via the formation of large multiprotein complexes. This group includes animal HDAC1, HDAC2, HDAC3, HDAC8, fungal RPD3, HOS1 and HOS2, plant HDA9, protist, archaeal and bacterial (AcuC) deacetylases. Members of this class are involved in cell cycle regulation, DNA damage response, embryonic development, cytokine signaling important for immune response and in posttranslational control of the acetyl coenzyme A synthetase. In mammals, they are known to be involved in progression of various tumors. Specific inhibitors of mammalian histone deacetylases are an emerging class of promising novel anticancer drugs.


Pssm-ID: 212517 [Multi-domain]  Cd Length: 306  Bit Score: 103.43  E-value: 3.09e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317  60 LVEAREASEEDLLVVHTRRYLNELKwsfvvatitEIPPviflPNFLVQRKVLR--------PL--------RTQTGGTIM 123
Cdd:cd09991  40 IYRPRPATAEELTKFHSDDYIDFLR---------SVSP----DNMKEFKKQLErfnvgedcPVfdglyeycQLYAGGSIA 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317 124 AG-KLA-VERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFL---FERVegisraTIIDLDAHQGNGHERDFMGDKRV 198
Cdd:cd09991 107 AAvKLNrGQADIAINWAGGLHHAKKSEASGFCYVNDIVLAILELlkyHQRV------LYIDIDIHHGDGVEEAFYTTDRV 180

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317 199 yiMDVyNRHIYPGDRFAKEAIR----RK-------VELEWGTEDEEYLEKVERNVRRSLQEHLPDVVVYNAGTDVLEGDR 267
Cdd:cd09991 181 --MTV-SFHKFGEYFFPGTGLRdigaGKgkyyavnVPLKDGIDDESYLQIFEPVLSKVMEVFQPSAVVLQCGADSLAGDR 257

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 21450317 268 LGGLSISPAGIVKrdevVFRVVRAHDIPILMVTSGGYQKR-TAR 310
Cdd:cd09991 258 LGCFNLSIKGHAK----CVKFVKSFNIPLLVLGGGGYTLRnVAR 297
HDAC8 cd10000
Histone deacetylase 8 (HDAC8); HDAC8 is a Zn-dependent class I histone deacetylase that ...
 54-304 5.43e-25

Histone deacetylase 8 (HDAC8); HDAC8 is a Zn-dependent class I histone deacetylase that catalyzes hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. Histone deacetylases usually act via association with DNA binding proteins to target specific chromatin regions. HDAC8 is found in human cytoskeleton-bound protein fraction and insoluble cell pellets. It plays a crucial role in intramembraneous bone formation; germline deletion of HDAC8 is detrimental to skull bone formation. HDAC8 is possibly associated with the smooth muscle actin cytockeleton and may regulate the contractive capacity of smooth muscle cells. HDAC8 is also involved in the metabolic control of the estrogen receptor related receptor (ERR)-alpha/peroxisome proliferator activated receptor (PPAR) gamma coactivator 1 alpha (PGC1-alpha) transcriptional complex as well as in the development of neuroblastoma and T-cell lymphoma. HDAC8-selective small-molecule inhibitors could be a therapeutic drug option for these diseases.


Pssm-ID: 212524 [Multi-domain]  Cd Length: 364  Bit Score: 103.57  E-value: 5.43e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317  54 LLSDGMLVEAREASEEDLLVVHTRRYLNELK----WSFVVATITEI---------PPVIFLPNFLvqrkvlrplRTQTGG 120
Cdd:cd10000  35 LLKQLRVVKPRVATEEELASFHSDEYIQFLKkasnEGDNDEEPSEQqefglgydcPIFEGIYDYA---------AAVAGA 105

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317 121 TIMAGKLAV--ERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEgisRATIIDLDAHQGNGHERDFMGDKRV 198
Cdd:cd10000 106 TLTAAQLLIdgKCKVAINWFGGWHHAQRDEASGFCYVNDIVLGILKLREKFD---RVLYVDLDLHHGDGVEDAFSFTSKV 182

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317 199 YI--MDVYNRHIYPGDRFAKEAIRRK-------VELEWGTEDEEYLEKVERNVRRSLQEHLPDVVVYNAGTDVLEGDRLG 269
Cdd:cd10000 183 MTvsLHKYSPGFFPGTGDVSDVGLGKgkyytvnVPLRDGIQDEQYLQIFTAVVPEIVAAFRPEAVVLQCGADTLAGDPMG 262

                       250       260       270
                ....*....|....*....|....*....|....*
gi 21450317 270 GLSISPAGIVKrdevVFRVVRAHDIPILMVTSGGY 304
Cdd:cd10000 263 AFNLTPVGIGK----CLKYVLGWKLPTLILGGGGY 293
HDAC_classII cd09992
Histone deacetylases and histone-like deacetylases, classII; Class II histone deacetylases are ...
 45-304 1.36e-24

Histone deacetylases and histone-like deacetylases, classII; Class II histone deacetylases are Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine residues of histones (EC 3.5.1.98) and possibly other proteins to yield deacetylated histones/other proteins. This group includes animal HDAC4,5,6,7,8,9,10, fungal HOS3 and HDA1, plant HDA5 and HDA15 as well as other eukaryotes, archaeal and bacterial histone-like deacetylases. Eukaryotic deacetylases mostly use histones (H2, H3, H4) as substrates for deacetylation; however, non-histone substrates are known (for example, tubulin). Substrates for prokaryotic histone-like deacetylases are not known. Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. Histone deacetylases usually act via association with DNA binding proteins to target specific chromatin regions. Interaction partners of class II deacetylases include 14-3-3 proteins, MEF2 family of transcriptional factors, CtBP, calmodulin (CaM), SMRT, N-CoR, BCL6, HP1alpha and SUMO. Histone deacetylases play a role in the regulation of cell cycle, cell differentiation and survival. Class II mammalian HDACs are differentially inhibited by structurally diverse compounds with known antitumor activities, thus presenting them as potential drug targets for human diseases resulting from aberrant acetylation.


Pssm-ID: 212518 [Multi-domain]  Cd Length: 291  Bit Score: 101.42  E-value: 1.36e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317  45 VINFLKEEKLLSDGMLVEAREASEEDLLVVHTRRYLNELKwSFVVATITEIPPVIFlpnflVQRKVLRPLRTQTGGTIMA 124
Cdd:cd09992  11 ILEALEEEGLLDRLVFVEPRPATEEELLRVHTPEYIERVE-ETCEAGGGYLDPDTY-----VSPGSYEAALLAAGAALAA 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317 125 GKlAVERGWAINvggGF-------HHCSSDRGGGFCAYADITLAIKFLFERVeGISRATIIDLDAHQGNGHERDFMGDKR 197
Cdd:cd09992  85 VD-AVLSGEAEN---AFalvrppgHHAEPDRAMGFCLFNNVAIAARYAQKRY-GLKRVLIVDWDVHHGNGTQDIFYDDPS 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317 198 VYIMDVYNRHIYPGDRFAKEAIRRK-------VELEWGTEDEEYLEKVERNVRRSLQEHLPDVVVYNAGTDVLEGDRLGG 270
Cdd:cd09992 160 VLYFSIHQYPFYPGTGAAEETGGGAgegftinVPLPPGSGDAEYLAAFEEVLLPIAREFQPDLVLVSAGFDAHRGDPLGG 239

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 21450317 271 LSISPAG---IVKRdeVVFRVVRAHDIPILMVTSGGY 304
Cdd:cd09992 240 MNLTPEGyarLTRL--LKELADEHCGGRLVFVLEGGY 274
HDAC_Hos1 cd11680
Class I histone deacetylases Hos1 and related proteins; Saccharomyces cerevisiae Hos1 is ...
 60-304 3.96e-23

Class I histone deacetylases Hos1 and related proteins; Saccharomyces cerevisiae Hos1 is responsible for Smc3 deacetylation. Smc3 is an important player during the establishment of sister chromatid cohesion. Hos1 belongs to the class I histone deacetylases (HDACs). HDACs are Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine residues in histone amino termini to yield a deacetylated histone (EC 3.5.1.98). Enzymes belonging to this group participate in regulation of a number of processes through protein (mostly different histones) modification (deacetylation). Class I histone deacetylases in general act via the formation of large multiprotein complexes. Other class I HDACs are animal HDAC1, HDAC2, HDAC3, HDAC8, fungal RPD3 and HOS2, plant HDA9, protist, archaeal and bacterial (AcuC) deacetylases. Members of this class are involved in cell cycle regulation, DNA damage response, embryonic development, cytokine signaling important for immune response and in posttranslational control of the acetyl coenzyme A synthetase.


Pssm-ID: 212543 [Multi-domain]  Cd Length: 294  Bit Score: 97.34  E-value: 3.96e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317  60 LVEAREASEEDLLVVHTRRYLNELKWSFvvATITEIPPVIFLPNFLvqrkvlrplRTQTGGTIMAGKL---AVERGWAIN 136
Cdd:cd11680  41 IIEPERATRKDLTKYHDKDYVDFLLKKY--GLEDDCPVFPFLSMYV---------QLVAGSSLALAKHlitQVERDIAIN 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317 137 VGGGFHHCSSDRGGGFCAYADITLAIKFLfeRVEGISRATIIDLDAHQGNGHERDFMGDKRVYIMDV--YNRHIYPGDRF 214
Cdd:cd11680 110 WYGGRHHAQKSRASGFCYVNDIVLAILRL--RRARFRRVFYLDLDLHHGDGVESAFFFSKNVLTCSIhrYDPGFFPGTGS 187

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317 215 AKEAIRRK---VELEWGTEDEEYLEKVERNVRRSLQEHLPDVVVYNAGTDVLEGDRLG--GLSISPAGIVkrdeVVFRVV 289
Cdd:cd11680 188 LKNSSDKGmlnIPLKRGLSDKTLLRIIDSIVRPLIEKFEPEVIVIQCGCDGLSGDPHKewNLTIRGYGSV----IELLLK 263

                       250
                ....*....|....*
gi 21450317 290 RAHDIPILMVTSGGY 304
Cdd:cd11680 264 EFKDKPTLLLGGGGY 278
HDAC_Clr3 cd11600
Class II Histone deacetylase Clr3 and similar proteins; Clr3 is a class II Histone ...
 35-277 1.89e-22

Class II Histone deacetylase Clr3 and similar proteins; Clr3 is a class II Histone deacetylase Zn-dependent enzyme that catalyzes hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone (EC 3.5.1.98). Clr3 is the homolog of the class-II HDAC HdaI in S. cerevisiae, and is essential for silencing in heterochromatin regions, such as centromeric regions, ribosomal DNA, the mating-type region and telomeric loci. Clr3 has also been implicated in the regulation of stress-related genes; the histone acetyltransferase, Gcn5, in S. cerevisiae, preferentially acetylates global histone H3K14 while Clr3 preferentially deacetylates H3K14ac, and therefore, interplay between Gcn5 and Clr3 is crucial for the regulation of many stress-response genes.


Pssm-ID: 212542 [Multi-domain]  Cd Length: 313  Bit Score: 95.87  E-value: 1.89e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317  35 HPFDAGKWGKVINFLKEEKLLSDGMLVEAREASEEDLLVVHTRRYlnelkWSFVVATITEIPPVIF-LPNFL------VQ 107
Cdd:cd11600   3 HPEDPSRISRIFEKLKEAGLINRMLRIPIREATKEEILLVHSEEH-----WDRVEATEKMSDEQLKdRTEIFerdslyVN 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317 108 RKVLRPLRTQTGGTIMAGKlAVERGwaiNVGGGF-------HHCSSDRGGGFCAYADITLAIKFL-FERVEGISRATIID 179
Cdd:cd11600  78 NDTAFCARLSCGGAIEACR-AVAEG---RVKNAFavvrppgHHAEPDESMGFCFFNNVAVAAKWLqTEYPDKIKKILILD 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317 180 LDAHQGNGHERDFMGDKRV-YI-MDVY-NRHIYPGDRFAK-------EAIRRKVELEW---GTEDEEYLEKVERNVRRSL 246
Cdd:cd11600 154 WDIHHGNGTQRAFYDDPNVlYIsLHRFeNGGFYPGTPYGDyesvgegAGLGFNVNIPWpqgGMGDADYIYAFQRIVMPIA 233

                       250       260       270
                ....*....|....*....|....*....|.
gi 21450317 247 QEHLPDVVVYNAGTDVLEGDRLGGLSISPAG 277
Cdd:cd11600 234 YEFDPDLVIISAGFDAADGDELGQCHVTPAG 264
HDAC_classII_APAH cd10001
Histone deacetylase class IIa; This subfamily includes bacterial acetylpolyamine ...
 18-304 3.29e-19

Histone deacetylase class IIa; This subfamily includes bacterial acetylpolyamine amidohydrolase (APAH) as well as other Class II histone deacetylase (HDAC) and related proteins. Deacetylases of class II are Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine residues of histones (EC 3.5.1.98) and possibly other proteins to yield deacetylated histones/other proteins. Mycoplana ramosa APAH exhibits broad substrate specificity and catalyzes the deacetylation of polyamines such as putrescine, spermidine, and spermine by cleavage of a non-peptide amide bond.


Pssm-ID: 212525 [Multi-domain]  Cd Length: 298  Bit Score: 86.44  E-value: 3.29e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317  18 IVYSPRYnitfmgleKLH----PFDAGKWGK----------VINFLKEEKLlsdGMLVEAREASEEDLLVVHTRRYLNEL 83
Cdd:cd10001   2 IVYSEDH--------LLHhpktELSRGKLVPhpenperaeaILDALKRAGL---GEVLPPRDFGLEPILAVHDPDYVDFL 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317  84 KwsfVVATITEIPPVIFlpnflvqrkvlRPLRTQTGGTIMAGKLAVE-RGWAINVG---GgfHHCSSDRGGGFCAYADIT 159
Cdd:cd10001  71 E---TADTDTPISEGTW-----------EAALAAADTALTAADLVLEgERAAYALCrppG--HHAGRDRAGGFCYFNNAA 134

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317 160 LAIKFLFERVEgisRATIIDLDAHQGNGHERDFMGDKRVYIMDV--YNRHIYPG------DRFAKEAIRRKVE--LEWGT 229
Cdd:cd10001 135 IAAQYLRDRAG---RVAILDVDVHHGNGTQEIFYERPDVLYVSIhgDPRTFYPFflgfadETGEGEGEGYNLNlpLPPGT 211

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21450317 230 EDEEYLEKVERNVRRsLQEHLPDVVVYNAGTDVLEGDRLGGLSISPAGIVKrdevVFRVVRAHDIPILMVTSGGY 304
Cdd:cd10001 212 GDDDYLAALDEALAA-IAAFGPDALVVSLGFDTHEGDPLSDFKLTTEDYAR----IGRRIAALGLPTVFVQEGGY 281
HDAC_Hos2 cd11598
Class I histone deacetylases including ScHos2 and SpPhd1; This subfamily includes Class I ...
 134-307 4.83e-19

Class I histone deacetylases including ScHos2 and SpPhd1; This subfamily includes Class I histone deacetylase (HDAC) Hos2 from Saccharomyces cerevisiae as well as a histone deacetylase Phd1 from Schizosaccharomyces pombe. Hos2 binds to the coding regions of genes during gene activation, specifically it deacetylates the lysines in H3 and H4 histone tails. It is preferentially associated with genes of high activity genome-wide and is shown to be necessary for efficient transcription. Thus, Hos2 is directly required for gene activation in contrast to other class I histone deacetylases. Protein encoded by phd1 is inhibited by trichostatin A (TSA), a specific inhibitor of histone deacetylase, and is involved in the meiotic cell cycle in S. pombe. Class 1 HDACs are Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine residues in histone amino termini to yield a deacetylated histone (EC 3.5.1.98).


Pssm-ID: 212540 [Multi-domain]  Cd Length: 311  Bit Score: 86.36  E-value: 4.83e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317 134 AINVGGGFHHCSSDRGGGFCAYADITLAIkflFERVEGISRATIIDLDAHQGNGHERDFMGDKRVYIMDV--YNRHIYPG 211
Cdd:cd11598 123 AINWSGGLHHAKKSEASGFCYVNDIVLAI---LNLLRYFPRVLYIDIDVHHGDGVEEAFYRTDRVMTLSFhkYNGEFFPG 199

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317 212 ---------DRFAKEAIrrKVELEWGTEDEEYLEKVERNVRRSLQEHLPDVVVYNAGTDVLEGDRLGGLSISpagIVKRD 282
Cdd:cd11598 200 tgdlddnggTPGKHFAL--NVPLEDGIDDEQYNLLFKSIIGPTIEKFQPSAIVLQCGADSLGGDRLGQFNLN---IKAHG 274

                       170       180
                ....*....|....*....|....*
gi 21450317 283 EVVfRVVRAHDIPILMVTSGGYQKR 307
Cdd:cd11598 275 ACV-KFVKSFGIPMLVVGGGGYTPR 298
HDAC2 cd10011
Histone deacetylase 2 (HDAC2); Histone deacetylase 2 (HDAC2) is a Zn-dependent class I enzyme ...
 118-307 1.27e-18

Histone deacetylase 2 (HDAC2); Histone deacetylase 2 (HDAC2) is a Zn-dependent class I enzyme that catalyzes hydrolysis of N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. HDAC2 is involved in regulation through association with DNA binding proteins to target specific chromatin regions. It forms transcriptional repressor complexes by associating with several proteins, including the mammalian zinc-finger transcription factor YY1, thus playing an important role in transcriptional regulation, cell cycle progression and developmental events. Additionally, a few non-histone HDAC2 substrates have been found. HDAC2 plays a role in embryonic development and cytokine signaling important for immune response, and is over-expressed in several solid tumors including oral, prostate, ovarian, endometrial and gastric cancer. It participates in DNA-damage response, along with HDAC1; together, they can promote DNA non-homologous end-joining. HDAC2 is considered an important cancer prognostic marker. Inhibitors specifically targeting HDAC2 could be a therapeutic drug option.


Pssm-ID: 212535 [Multi-domain]  Cd Length: 366  Bit Score: 85.89  E-value: 1.27e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317 118 TGGTImAGKLAVER---GWAINVGGGFHHCSSDRGGGFCAYADITLAIkflFERVEGISRATIIDLDAHQGNGHERDFMG 194
Cdd:cd10011 107 TGGSV-AGAVKLNRqqtDMAVNWAGGLHHAKKSEASGFCYVNDIVLAI---LELLKYHQRVLYIDIDIHHGDGVEEAFYT 182

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317 195 DKRVY-IMDVYNRHIYPG-----DRFAKEAIRRKVELEW--GTEDEEYLEKVERNVRRSLQEHLPDVVVYNAGTDVLEGD 266
Cdd:cd10011 183 TDRVMtVSFHKYGEYFPGtgdlrDIGAGKGKYYAVNFPMrdGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGD 262

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 21450317 267 RLGGLSISPAGIVKRDEvvfrVVRAHDIPILMVTSGGYQKR 307
Cdd:cd10011 263 RLGCFNLTVKGHAKCVE----VVKTFNLPLLMLGGGGYTIR 299
HDAC_classII_1 cd09996
Histone deacetylases and histone-like deacetylases, classII; This subfamily includes bacterial ...
 47-261 3.19e-17

Histone deacetylases and histone-like deacetylases, classII; This subfamily includes bacterial as well as eukaryotic Class II histone deacetylase (HDAC) and related proteins. Deacetylases of class II are Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine residues of histones (EC 3.5.1.98) and possibly other proteins to yield deacetylated histones/other proteins. Included in this family is a bacterial HDAC-like amidohydrolase (Bordetella/Alcaligenes species FB18817, denoted as FB188 HDAH) shown to be most similar in sequence and function to class II HDAC6 domain 3 or b (HDAC6b). FB188 HDAH is able to remove the acetyl moiety from acetylated histones, and can be inhibited by common HDAC inhibitors such as SAHA (suberoylanilide hydroxamic acid) as well as class II-specific but not class I specific inhibitors.


Pssm-ID: 212521 [Multi-domain]  Cd Length: 359  Bit Score: 81.45  E-value: 3.19e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317  47 NFLKEEKLLSDGMLVEAREASEEDLLVVHTRRYLNELKwSFVVATITEIPPVIFLPN--FLVQRKvlrplrtQTGGTI-- 122
Cdd:cd09996  45 NLLEVSGLSDHLVLITPRPATDEELLRVHTPEYIDRVK-AASAAGGGEAGGGTPFGPgsYEIALL-------AAGGAIaa 116

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317 123 ----MAGKlaVERGWAINVGGGfHHCSSDRGGGFCAYADITLAIKFLFERvEGISRATIIDLDAHQGNGHERDFMGDKRV 198
Cdd:cd09996 117 vdavLDGE--VDNAYALVRPPG-HHAEPDQGMGFCLFNNVAIAARHALAV-GGVKRVAVVDWDVHHGNGTQAIFYDDPDV 192

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21450317 199 YIMDVYNRHIYPGDRFAKEAIRR--------KVELEWGTEDEEYLEKVERNVRRSLQEHLPDVVVYNAGTD 261
Cdd:cd09996 193 LTISLHQDRCFPPDSGAVEERGEgagegynlNIPLPPGSGDGAYLHAFERIVLPALRAFRPELIIVASGFD 263
HDAC_classII_2 cd11599
Histone deacetylases and histone-like deacetylases, classII; This subfamily includes ...
 60-272 1.05e-16

Histone deacetylases and histone-like deacetylases, classII; This subfamily includes eukaryotic as well as bacterial Class II histone deacetylase (HDAC) and related proteins. Deacetylases of class II are Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine residues of histones (EC 3.5.1.98) and possibly other proteins to yield deacetylated histones/other proteins. In D. discoideum, where four homologs (HdaA, HdaB, HdaC, HdaD) have been identified, HDAC activity is important for regulating the timing of gene expression during development. Also, inhibition of HDAC activity by trichostatin A is shown to cause hyperacetylation of the histone and a delay in cell aggregation and differentiation.


Pssm-ID: 212541 [Multi-domain]  Cd Length: 288  Bit Score: 79.09  E-value: 1.05e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317  60 LVEAREASEEDLLVVHTRRYLNELKwsfvvatiTEIP--PVIFL-PNFLVQRKVLRPLRTQTGGTIMAGKlAVERGWAIN 136
Cdd:cd11599  26 QLEAPPATREQLLRVHDAAYVDRLE--------AAAPeeGLVQLdPDTAMSPGSLEAALRAAGAVVAAVD-AVMAGEARN 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317 137 VgggF-------HHCSSDRGGGFCAYADITLAIKFLFERVeGISRATIIDLDAHQGNGHERDFMGDKRVYIMDVYNRHIY 209
Cdd:cd11599  97 A---FcavrppgHHAERDKAMGFCLFNNVAIAAAHALAHH-GLERVAIVDFDVHHGNGTEDIFRDDPRVLFCSSHQHPLY 172

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 21450317 210 PGDRFAKEAIR---RKVELEWGTEDEEYLEKVERNVRRSLQEHLPDVVVYNAGTDVLEGDRLGGLS 272
Cdd:cd11599 173 PGTGAPDETGHgniVNVPLPAGTGGAEFREAVEDRWLPALDAFKPDLILISAGFDAHRDDPLAQLN 238
HDAC3 cd10005
Histone deacetylase 3 (HDAC3); HDAC3 is a Zn-dependent class I histone deacetylase that ...
 134-307 2.76e-16

Histone deacetylase 3 (HDAC3); HDAC3 is a Zn-dependent class I histone deacetylase that catalyzes hydrolysis of N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. In order to target specific chromatin regions, HDAC3 can interact with DNA-binding proteins (transcriptional factors) either directly or after forming complexes with a number of other proteins, as observed for the SMPT/N-CoR complex which recruits human HDAC3 to specific chromatin loci and activates deacetylation. Human HDAC3 is also involved in deacetylation of non-histone substrates such as RelA, SPY and p53 factors. This protein can also down-regulate p53 function and subsequently modulate cell growth and apoptosis. This gene is therefore regarded as a potential tumor suppressor gene. HDAC3 plays a role in various physiological processes, including subcellular protein localization, cell cycle progression, cell differentiation, apoptosis and survival. HDAC3 has been found to be overexpressed in some tumors including leukemia, lung carcinoma, colon cancer and maxillary carcinoma. Thus, inhibitors precisely targeting HDAC3 (in some cases together with retinoic acid or hyperthermia) could be a therapeutic drug option.


Pssm-ID: 212529  Cd Length: 381  Bit Score: 78.98  E-value: 2.76e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317 134 AINVGGGFHHCSSDRGGGFCAYADITLAIkflFERVEGISRATIIDLDAHQGNGHERDFMGDKRVyiMDV----YNRHIY 209
Cdd:cd10005 124 AINWSGGLHHAKKFEASGFCYVNDIVIAI---LELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRV--MTVsfhkYGNYFF 198

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317 210 P--GDRFAKEAIRRK-----VELEWGTEDEEYLEKVERNVRRSLQEHLPDVVVYNAGTDVLEGDRLGGLSISPAGivkRD 282
Cdd:cd10005 199 PgtGDMYEVGAESGRyysvnVPLKDGIDDQSYLQLFKPVIQQVIDFYQPTCIVLQCGADSLGCDRLGCFNLSIKG---HG 275

                       170       180
                ....*....|....*....|....*
gi 21450317 283 EVVfRVVRAHDIPILMVTSGGYQKR 307
Cdd:cd10005 276 ECV-EFVKSFNIPLLVLGGGGYTVR 299
HDAC1 cd10010
Histone deacetylase 1 (HDAC1); Histone deacetylase 1 (HDAC1) is a Zn-dependent class I enzyme ...
 118-307 1.06e-15

Histone deacetylase 1 (HDAC1); Histone deacetylase 1 (HDAC1) is a Zn-dependent class I enzyme that catalyzes hydrolysis of N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. HDAC1 is involved in regulation through association with DNA binding proteins to target specific chromatin regions. In particular, HDAC1 appears to play a major role in pre-implantation embryogenesis in establishing a repressive chromatin state. Its interaction with retinoblastoma tumor-suppressor protein is essential in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2 (MTA2), it deacetylates p53, thereby modulating its effect on cell growth and apoptosis. It participates in DNA-damage response, along with HDAC2; together, they promote DNA non-homologous end-joining. HDAC1 is also involved in tumorogenesis; its overexpression modulates cancer progression. Specific inhibitors of HDAC1 are currently used in cancer therapy.


Pssm-ID: 212534 [Multi-domain]  Cd Length: 371  Bit Score: 77.41  E-value: 1.06e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317 118 TGGTIMAG-KLAVER-GWAINVGGGFHHCSSDRGGGFCAYADITLAIkflFERVEGISRATIIDLDAHQGNGHERDFMGD 195
Cdd:cd10010 111 AGGSVASAvKLNKQQtDIAVNWAGGLHHAKKSEASGFCYVNDIVLAI---LELLKYHQRVLYIDIDIHHGDGVEEAFYTT 187

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317 196 KRVYIMDVYNR-HIYPG-----DRFAKEAIRRKVE--LEWGTEDEEYLEKVERNVRRSLQEHLPDVVVYNAGTDVLEGDR 267
Cdd:cd10010 188 DRVMTVSFHKYgEYFPGtgdlrDIGAGKGKYYAVNypLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGADSLSGDR 267

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 21450317 268 LGGLSISPAGIVKRDEvvfrVVRAHDIPILMVTSGGYQKR 307
Cdd:cd10010 268 LGCFNLTIKGHAKCVE----FVKSFNLPMLMLGGGGYTIR 303
HDAC6-dom2 cd10003
Histone deacetylase 6, domain 2; Histone deacetylase 6 is a class IIb Zn-dependent enzyme that ...
 32-277 1.57e-15

Histone deacetylase 6, domain 2; Histone deacetylase 6 is a class IIb Zn-dependent enzyme that catalyzes hydrolysis of N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. HDACs usually act via association with DNA binding proteins to target specific chromatin regions. HDAC6 is the only histone deacetylase with internal duplication of two catalytic domains which appear to function independently of each other, and also has a C-terminal ubiquitin-binding domain. It is located in the cytoplasm and associates with microtubule motor complex, functioning as the tubulin deacetylase and regulating microtubule-dependent cell motility. Known interaction partners of HDAC6 are alpha tubulin and ubiquitin-like modifier FAT10 (also known as Ubiquitin D or UBD).


Pssm-ID: 212527 [Multi-domain]  Cd Length: 350  Bit Score: 76.61  E-value: 1.57e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317  32 EKLHPFDAGKWGKVINFLKEEKLLSDGMLVEAREASEEDLLVVHTRRYLNELKwsfvvATITEIPPVIF-----LPNFLV 106
Cdd:cd10003  13 DPGHPECPQRISRIYERHNDLGLLERCLRLPSRLATEDELLLCHSEEHLDEMK-----SLEKMKPRELNrlgkeYDSIYI 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317 107 QRKVLRPLRTQTGGTIMAGKlAVERGWAINvGGGF-----HHCSSDRGGGFCAYADITLAIKFLFERvEGISRATIIDLD 181
Cdd:cd10003  88 HPDSYQCALLAAGCVLQVVE-AVLTGESRN-GVAIvrppgHHAEQDTACGFCFFNNVAIAARYAQKK-YGLKRILIVDWD 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317 182 AHQGNGHERDFMGDKRV-YI-MDVY-NRHIYPGDRFAKEAIRRK-------VELEW---GTEDEEYLEKVERNVRRSLQE 248
Cdd:cd10003 165 VHHGNGTQHMFESDPSVlYIsLHRYdNGSFFPNSPEGNYDVVGKgkgegfnVNIPWnkgGMGDAEYIAAFQQVVLPIAYE 244

                       250       260
                ....*....|....*....|....*....
gi 21450317 249 HLPDVVVYNAGTDVLEGDRLGGLSISPAG 277
Cdd:cd10003 245 FNPELVLVSAGFDAARGDPLGGCKVTPEG 273
HDAC6-dom1 cd11682
Histone deacetylase 6, domain 1; Histone deacetylases 6 are class IIb Zn-dependent enzymes ...
 35-346 2.34e-15

Histone deacetylase 6, domain 1; Histone deacetylases 6 are class IIb Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. HDACs usually act via association with DNA binding proteins to target specific chromatin regions. HDAC6 is the only histone deacetylase with internal duplication of two catalytic domains which appear to function independently of each other, and also has a C-terminal ubiquitin-binding domain. It is located in the cytoplasm and associates with microtubule motor complex, functioning as the tubulin deacetylase and regulating microtubule-dependent cell motility. Known interaction partners of HDAC6 are alpha tubulin (substrate) and ubiquitin-like modifier FAT10 (also known as Ubiquitin D or UBD).


Pssm-ID: 212545 [Multi-domain]  Cd Length: 337  Bit Score: 76.04  E-value: 2.34e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317  35 HPFDAGKWGKVINFLKEEKLLSDGMLVEAREASEEDLLVVHTRRYLNELKWSFVVA-----TITEIPPVIFL-PNF---- 104
Cdd:cd11682   7 FPECPERLHAIREKLIQEGLLERCVSVQAREASEEELLLVHSPEYVALMKSTQYMTeeelrTLADTYDSVYLhPNSysca 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317 105 -LVQRKVLRPLRTQTGGTImagklavERGWAINVGGGfHHCSSDRGGGFCAYADITLAIKFLFERvEGISRATIIDLDAH 183
Cdd:cd11682  87 cLAVGSVLQLVDKVLGGEI-------RNGLAIVRPPG-HHAQHDKMDGYCMFNNVAIAARYAQQK-HGVQRVLIVDWDVH 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317 184 QGNGHERDFMGDKRVYIMDVynrHIYPGDRF---AKEAI----------RRKVELEW---GTEDEEYLEKVERNVRRSLQ 247
Cdd:cd11682 158 HGQGTQFIFEQDPSVLYFSI---HRYEQGRFwphLKESDssavgfgrgeGYNINVPWnqvGMRDADYIAAFLHVLLPVAL 234

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317 248 EHLPDVVVYNAGTDVLEGDRLGGLSISPAGIVKRDEVVFRVVRAHdipILMVTSGGYQKR-TARIIADSILNLhdLG--- 323
Cdd:cd11682 235 EFQPQLVLVAAGFDAVIGDPKGEMAATPACFAHLTHLLMGLAGGK---LILSLEGGYNLRsLAEGVCASLKAL--LGdpc 309

                       330       340
                ....*....|....*....|....*
gi 21450317 324 --LIGPEFPCVSAQNSgiplLSCAV 346
Cdd:cd11682 310 pmLESPGAPCRSALAS----VSCTI 330
PTZ00346 PTZ00346
histone deacetylase; Provisional
 69-322 9.80e-15

histone deacetylase; Provisional


Pssm-ID: 240374 [Multi-domain]  Cd Length: 429  Bit Score: 74.68  E-value: 9.80e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317   69 EDLLVVHTRRYLNEL------KWSFVVATIT-----EIPPViflpNFLVQRKVLRPLRTQTGGTIM-AGKLAVERGWain 136
Cdd:PTZ00346  77 EELMAYHTDTYLANLglhscrSWLWNAETSKvffsgDCPPV----EGLMEHSIATASGTLMGAVLLnSGQVDVAVHW--- 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317  137 vGGGFHHCSSDRGGGFCAYADITLAIkflFERVEGISRATIIDLDAHQGNGHERDFMGDKRVYIMDV--YNRHIYPGDRF 214
Cdd:PTZ00346 150 -GGGMHHSKCGECSGFCYVNDIVLGI---LELLKCHDRVLYVDIDMHHGDGVDEAFCTSDRVFTLSLhkFGESFFPGTGH 225

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317  215 AKEA-------IRRKVELEWGTEDEEYLEKVERNVRRSLQEHLPDVVVYNAGTDVLEGDRLGGLSISPAGIVKrdevVFR 287
Cdd:PTZ00346 226 PRDVgygrgryYSMNLAVWDGITDFYYLGLFEHALHSIVRRYSPDAIVLQCGADSLAGDRLGLLNLSSFGHGQ----CVQ 301

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 21450317  288 VVRAHDIPILMVTSGGYQKR-TARIIA--DSILNLHDL 322
Cdd:PTZ00346 302 AVRDLGIPMLALGGGGYTIRnVAKLWAyeTSILTGHPL 339
RPD3-like cd10004
reduced potassium dependency-3 (RPD3)-like; Proteins of the Rpd3-like family are class I ...
 118-307 1.04e-14

reduced potassium dependency-3 (RPD3)-like; Proteins of the Rpd3-like family are class I Zn-dependent Histone deacetylases that catalyze hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone (EC 3.5.1.98). RPD3 is the yeast homolog of class I HDACs. The main function of RPD3-like group members is regulation of a number of different processes through protein (mostly different histones) modification (deacetylation). This group includes fungal RPD3 and acts via the formation of large multiprotein complexes. Members of this group are involved in cell cycle regulation, DNA damage response, embryonic development and cytokine signaling important for immune response. Histone deacetylation by yeast RPD3 represses genes regulated by the Ash1 and Ume6 DNA-binding proteins. In mammals, they are known to be involved in progression of various tumors. Specific inhibitors of mammalian histone deacetylases could be a therapeutic drug option.


Pssm-ID: 212528 [Multi-domain]  Cd Length: 375  Bit Score: 74.46  E-value: 1.04e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317 118 TGGTIMAGKLAVERG---WAINVGGGFHHCSSDRGGGFCAYADITLAIkflFERVEGISRATIIDLDAHQGNGHERDFMG 194
Cdd:cd10004 106 SAGGSMEGAARLNRGkcdIAVNWAGGLHHAKKSEASGFCYVNDIVLGI---LELLRYHQRVLYIDIDVHHGDGVEEAFYT 182

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317 195 DKRVYIMDVYNR-HIYPGDRFAKE---------AIrrKVELEWGTEDEEYLEKVERNVRRSLQEHLPDVVVYNAGTDVLE 264
Cdd:cd10004 183 TDRVMTCSFHKYgEYFPGTGELRDigigtgknyAV--NVPLRDGIDDESYKSIFEPVIKHVMEWYQPEAVVLQCGGDSLS 260

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 21450317 265 GDRLGGLSISPAGivkrDEVVFRVVRAHDIPILMVTSGGYQKR 307
Cdd:cd10004 261 GDRLGCFNLSMKG----HANCVNFVKSFNLPMLVLGGGGYTMR 299
PTZ00063 PTZ00063
histone deacetylase; Provisional
 135-322 1.07e-14

histone deacetylase; Provisional


Pssm-ID: 240251  Cd Length: 436  Bit Score: 74.46  E-value: 1.07e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317  135 INVGGGFHHCSSDRGGGFCAYADITLAIkflFERVEGISRATIIDLDAHQGNGHERDFMGDKRVYIMDVYN-RHIYP--G 211
Cdd:PTZ00063 130 VNWSGGLHHAKRSEASGFCYINDIVLGI---LELLKYHARVMYIDIDVHHGDGVEEAFYVTHRVMTVSFHKfGDFFPgtG 206

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317  212 DRFAKEAIRRK-----VELEWGTEDEEYLEKVERNVRRSLQEHLPDVVVYNAGTDVLEGDRLGGLSISpagiVKRDEVVF 286
Cdd:PTZ00063 207 DVTDIGVAQGKyysvnVPLNDGIDDDSFVDLFKPVISKCVEVYRPGAIVLQCGADSLTGDRLGRFNLT----IKGHAACV 282

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 21450317  287 RVVRAHDIPILMVTSGGYQKR-TARIIA---DSILNLHDL 322
Cdd:PTZ00063 283 EFVRSLNIPLLVLGGGGYTIRnVARCWAyetGVILNKHDE 322
HDAC5 cd10007
Histone deacetylase 5; Histone deacetylase 5 is a class IIa Zn-dependent enzyme that catalyzes ...
 27-274 6.45e-14

Histone deacetylase 5; Histone deacetylase 5 is a class IIa Zn-dependent enzyme that catalyzes hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. Histone deacetylases usually act via association with DNA binding proteins to target specific chromatin regions. Class IIa histone deacetylases are signal-dependent co-repressors, having N-terminal regulatory domain with two or three conserved serine residues; phosphorylation of these residues is important for ability to shuttle between the nucleus and cytoplasm and act as transcriptional co-repressors. HDAC5 is involved in integration of chronic drug (cocaine) addiction and depression with changes in chromatin structure and gene expression; cocaine regulates HDAC5 function to antagonize the rewarding impact of cocaine, possibly by blocking drug-stimulated gene expression that supports drug-induced behavioral change. It is also involved in regulation of angiogenesis and cell cycle as well as immune system development. HDAC5 and HDAC9 have been found to be significantly up-regulated in high-risk medulloblastoma compared with low-risk and may potentially be novel drug targets.


Pssm-ID: 212531 [Multi-domain]  Cd Length: 420  Bit Score: 72.33  E-value: 6.45e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317  27 TFM-------GLEKLHPFDAGKWGKVINFLKEEKLLSDGMLVEAREASEEDLLVVHTRRY--------LN--ELKWSFVV 89
Cdd:cd10007  11 TFMlkhqctcGNTNVHPEHAGRIQSVWSRLQETGLLGKCERVRGRKATLDEIQTVHSEHHtllygtspLNrqKLDSKKLL 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317  90 ATITE----IPPV--IFLPNFLVQRKVLRP--LRTQTGGTI-MAGKLA---VERGWAINVGGGfHHCSSDRGGGFCAYAD 157
Cdd:cd10007  91 GPLSQkmyaVLPCggIGVDSDTVWNEMHSSsaVRMAVGCLIeLAFKVAageLKNGFAVIRPPG-HHAEESTAMGFCFFNS 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317 158 ITLAIKFLFERVeGISRATIIDLDAHQGNGHERDFMGDKRVYIMDVY---NRHIYPGDRFAKE-----AIRRKVELEW-- 227
Cdd:cd10007 170 VAIAAKLLQQKL-NVGKILIVDWDIHHGNGTQQAFYNDPNVLYISLHrydDGNFFPGSGAPDEvgagpGVGFNVNIAWtg 248

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 21450317 228 GTE----DEEYLEKVERNVRRSLQEHLPDVVVYNAGTDVLEGDR--LGGLSIS 274
Cdd:cd10007 249 GVDppigDVEYLTAFRTVVMPIANEFSPDVVLVSAGFDAVEGHQspLGGYSVT 301
HDAC7 cd10008
Histone deacetylase 7; Histone deacetylase 7 is a class IIa Zn-dependent enzyme that catalyzes ...
 35-274 3.37e-13

Histone deacetylase 7; Histone deacetylase 7 is a class IIa Zn-dependent enzyme that catalyzes hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. Histone deacetylases usually act via association with DNA binding proteins to target specific chromatin regions. Class IIa histone deacetylases are signal-dependent co-repressors, having N-terminal regulatory domain with two or three conserved serine residues; phosphorylation of these residues is important for ability to shuttle between the nucleus and cytoplasm and act as transcriptional co-repressors. HDAC7 is involved in regulation of myocyte migration and differentiation. Known interaction partners of class IIa HDAC7 are myocyte enhancer factors - MEF2A, -2C, and -2D, 14-3-3 proteins, SMRT and N-CoR co-repressors, HDAC3, ETA (endothelin receptor). This enzyme is also involved in the development of the immune system as well as brain and heart development. Multiple alternatively spliced transcript variants encoding several isoforms have been found for this gene.


Pssm-ID: 212532 [Multi-domain]  Cd Length: 378  Bit Score: 69.65  E-value: 3.37e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317  35 HPFDAGKWGKVINFLKEEKLLSDGMLVEAREASEEDLLVVHTRRY--------LNELKW-SFVVATITEIPPVIFLP--- 102
Cdd:cd10008  24 HPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHvllygtnpLSRLKLdNGKLAGLLAQRMFVMLPcgg 103

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317 103 ---------NFLVQRKVLRplrtQTGGTI--MAGKLA---VERGWAINVGGGfHHCSSDRGGGFCAYADITLAIKFLFER 168
Cdd:cd10008 104 vgvdtdtiwNELHSSNAAR----WAAGSVtdLAFKVAsreLKNGFAVVRPPG-HHADHSTAMGFCFFNSVAIACRQLQQQ 178

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317 169 VEgISRATIIDLDAHQGNGHERDFMGDKRVYIMDVYnRH----IYPGDRFAKEAIRR-----KVELEW--GTE----DEE 233
Cdd:cd10008 179 GK-ASKILIVDWDVHHGNGTQQTFYQDPSVLYISLH-RHddgnFFPGSGAVDEVGAGsgegfNVNVAWagGLDppmgDPE 256

                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 21450317 234 YLEKVERNVRRSLQEHLPDVVVYNAGTDVLEGD--RLGGLSIS 274
Cdd:cd10008 257 YLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHpaPLGGYHVS 299
HDAC9 cd10009
Histone deacetylase 9; Histone deacetylase 9 is a class IIa Zn-dependent enzyme that catalyzes ...
 35-274 1.86e-12

Histone deacetylase 9; Histone deacetylase 9 is a class IIa Zn-dependent enzyme that catalyzes hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. Histone deacetylases usually act via association with DNA binding proteins to target specific chromatin regions. Class IIa histone deacetylases are signal-dependent co-repressors, they have N-terminal regulatory domain with two or three conserved serine residues, phosphorylation of these residues is important for ability to shuttle between the nucleus and cytoplasm and act as transcriptional co-repressors. HDAC9 is involved in regulation of gene expression and dendritic growth in developing cortical neurons. It also plays a role in hematopoiesis. Its deregulated expression may be associated with some human cancers. HDAC5 and HDAC9 have been found to be significantly up-regulated in high-risk medulloblastoma compared with low-risk and may potentially be novel drug targets.


Pssm-ID: 212533 [Multi-domain]  Cd Length: 379  Bit Score: 67.73  E-value: 1.86e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317  35 HPFDAGKWGKVINFLKEEKLLSDGMLVEAREASEEDLLVVHTRRYlnELKWSFVVATITEIPPVIFLPNflVQRKVLRPL 114
Cdd:cd10009  24 HPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHH--SLLYGTNPLDGQKLDPRILLGD--DSQKFFSSL 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317 115 ----------------------RTQTGGTI-MAGKLA---VERGWAINVGGGfHHCSSDRGGGFCAYADITLAIKFLFER 168
Cdd:cd10009 100 pcgglgvdsdtiwnelhssgaaRMAVGCVIeLASKVAsgeLKNGFAVVRPPG-HHAEESTAMGFCFFNSVAITAKYLRDQ 178

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317 169 VEgISRATIIDLDAHQGNGHERDFMGDKRVYIMDVYNR---HIYPGDRFAKEAIR-----RKVELEW--GTE----DEEY 234
Cdd:cd10009 179 LN-ISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYdegNFFPGSGAPNEVGTglgegYNINIAWtgGLDppmgDVEY 257

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 21450317 235 LEKVERNVRRSLQEHLPDVVVYNAGTDVLEGDR--LGGLSIS 274
Cdd:cd10009 258 LEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTppLGGYKVT 299
HDAC10_HDAC6-dom1 cd10002
Histone deacetylase 6, domain 1 and histone deacetylase 10; Histone deacetylases 6 and 10 are ...
 49-303 2.44e-12

Histone deacetylase 6, domain 1 and histone deacetylase 10; Histone deacetylases 6 and 10 are class IIb Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. HDACs usually act via association with DNA binding proteins to target specific chromatin regions. HDAC6 is the only histone deacetylase with internal duplication of two catalytic domains which appear to function independently of each other, and also has a C-terminal ubiquitin-binding domain. It is located in the cytoplasm and associates with microtubule motor complex, functioning as the tubulin deacetylase and regulating microtubule-dependent cell motility. HDAC10 has an N-terminal deacetylase domain and a C-terminal pseudo-repeat that shares significant similarity with its catalytic domain. It is located in the nucleus and cytoplasm, and is involved in regulation of melanogenesis. It transcriptionally down-regulates thioredoxin-interacting protein (TXNIP), leading to altered reactive oxygen species (ROS) signaling in human gastric cancer cells. Known interaction partners of HDAC6 are alpha tubulin (substrate) and ubiquitin-like modifier FAT10 (also known as Ubiquitin D or UBD) while interaction partners of HDAC10 are Pax3, KAP1, hsc70 and HDAC3 proteins.


Pssm-ID: 212526 [Multi-domain]  Cd Length: 336  Bit Score: 66.95  E-value: 2.44e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317  49 LKEEKLLSDGMLVEAREASEEDLLVVHTRRYLNELKwSFVVATITEIPP-------VIFLPN-FLVQRKVLrplrtqtGG 120
Cdd:cd10002  21 LTQDGLLERCVKIPAREAEEDEILLVHSQEYIDLVK-STETMEKEELESlcsgydsVYLCPStYEAARLAA-------GS 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317 121 TIMAGKLAVERGwainVGGGF-------HHCSSDRGGGFCAYADITLAIKFLFErVEGISRATIIDLDAHQGNGHERDFM 193
Cdd:cd10002  93 TIELVKAVMAGK----IQNGFalirppgHHAMRNEANGYCIFNNVAIAAKYAIE-KLGLKRILIVDWDVHHGQGTQQGFY 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317 194 GDKRVyimDVYNRHIYPGDRF-------------AKEAIRRKVELEWGTE---DEEYLEKVERNVRRSLQEHLPDVVVYN 257
Cdd:cd10002 168 EDPRV---LYFSIHRYEHGRFwphlfesdydyigVGHGYGFNVNVPLNQTglgDADYLAIFHHILLPLALEFQPELVLVS 244

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 21450317 258 AGTDVLEGDRLGGLSISPAGIvkrdevvfrvvrAHDIPILMVTSGG 303
Cdd:cd10002 245 AGFDASIGDPEGEMAVTPAGY------------AHLTRLLMGLAGG 278
HDAC4 cd10006
Histone deacetylase 4; Histone deacetylase 4 is a class IIa Zn-dependent enzyme that catalyzes ...
 30-274 4.03e-12

Histone deacetylase 4; Histone deacetylase 4 is a class IIa Zn-dependent enzyme that catalyzes hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. Histone deacetylases usually act via association with DNA binding proteins to target specific chromatin regions. Class IIa histone deacetylases are signal-dependent co-repressors, having N-terminal regulatory domain with two or three conserved serine residues; phosphorylation of these residues is important for ability to shuttle between the nucleus and cytoplasm and act as transcriptional co-repressors. HDAC4 participates in regulation of chondrocyte hypertrophy and skeletogenesis. However, biological substrates for HDAC4 have not been identified; only low lysine deacetylation activity has been demonstrated and active site mutant has enhanced activity toward acetylated lysines. HDAC4 does not bind DNA directly, but through transcription factors MEF2C (myocyte enhancer factor-2C) and MEF2D. Other known interaction partners of the protein are 14-3-3 proteins, SMRT and N-CoR co-repressors, BCL6, HP1, SUMO-1 ubiquitin-like protein, and ANKRA2. It appears to interact in a multiprotein complex with RbAp48 and HDAC3. Furthermore, HDAC4 is required for TGFbeta1-induced myofibroblastic differentiation.


Pssm-ID: 212530 [Multi-domain]  Cd Length: 409  Bit Score: 66.60  E-value: 4.03e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317  30 GLEKLHPFDAGKWGKVINFLKEEKLLSDGMLVEAREASEEDLLVVHTRRY--------LNELKWSFVVATITEIPPVIFL 101
Cdd:cd10006  22 GNSNSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHtllygtnpLNRQKLDSKKLLGSLASVFVRL 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317 102 P--NFLVQRKVLRPLRTQTGGTIMAGKLAVERGWAINVG---GGF-------HHCSSDRGGGFCAYADITLAIKFLFERV 169
Cdd:cd10006 102 PcgGVGVDSDTIWNEVHSSGAARLAVGCVVELVFKVATGelkNGFavvrppgHHAEESTPMGFCYFNSVAIAAKLLQQRL 181

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317 170 EgISRATIIDLDAHQGNGHERDFMGDKRVYIMDVY---NRHIYPGDRFAKE-----AIRRKVELEW--GTE----DEEYL 235
Cdd:cd10006 182 N-VSKILIVDWDVHHGNGTQQAFYSDPNVLYMSLHrydDGNFFPGSGAPDEvgtgpGVGFNVNMAFtgGLDppmgDAEYL 260

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 21450317 236 EKVERNVRRSLQEHLPDVVVYNAGTDVLEGD--RLGGLSIS 274
Cdd:cd10006 261 AAFRTVVMPIASEFAPDVVLVSSGFDAVEGHptPLGGYNLS 301
HDAC_classIIa cd11681
Histone deacetylases, class IIa; Class IIa histone deacetylases are Zn-dependent enzymes that ...
 35-276 3.56e-10

Histone deacetylases, class IIa; Class IIa histone deacetylases are Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine residues of histones (EC 3.5.1.98) to yield deacetylated histones. This subclass includes animal HDAC4, HDAC5, HDAC7, and HDCA9. Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. Histone deacetylases usually act via association with DNA binding proteins to target specific chromatin regions. Class IIa histone deacetylases are signal-dependent co-repressors, they have N-terminal regulatory domain with two or three conserved serine residues, phosphorylation of these residues is important for ability to shuttle between the nucleus and cytoplasm and act as transcriptional co-repressors. HDAC9 is involved in regulation of gene expression and dendritic growth in developing cortical neurons. It also plays a role in hematopoiesis. HDAC7 is involved in regulation of myocyte migration and differentiation. HDAC5 is involved in integration of chronic drug (cocaine) addiction and depression with changes in chromatin structure and gene expression. HDAC4 participates in regulation of chondrocyte hypertrophy and skeletogenesis.


Pssm-ID: 212544 [Multi-domain]  Cd Length: 377  Bit Score: 60.44  E-value: 3.56e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317  35 HPFDAGKWGKVINFLKEEKLLSDGMLVEAREASEEDLLVVHTRRY--------LNELKWSfvvATITEIPPvifLPNFLV 106
Cdd:cd11681  24 HPEHGGRLQSIWSRLQETGLVNRCERLRGRKATLEELQLVHSEVHtllygtnpLSRLKLD---PTKLAGLP---QKSFVR 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317 107 ---------QRKVLRPLRTQTGGTIMAG-----KLAVERGWAINvggGF-------HHCSSDRGGGFCAYADITLAIKFL 165
Cdd:cd11681  98 lpcggigvdSDTVWNELHTSNAARMAVGcvidlAFKVATGELKN---GFavvrppgHHAEPSQAMGFCFFNSVAIAAKQL 174

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317 166 FERVeGISRATIIDLDAHQGNGHERDFMGDKRVYIMDVYnRH----IYPGDRFAKE-----AIRRKVELEW------GTE 230
Cdd:cd11681 175 QQKL-KLRKILIVDWDVHHGNGTQQIFYEDPNVLYISLH-RYddgnFFPGTGAPTEvgsgaGEGFNVNIAWsggldpPMG 252

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 21450317 231 DEEYLEKVERNVRRSLQEHLPDVVVYNAGTDVLEG--DRLGGLSISPA 276
Cdd:cd11681 253 DAEYLAAFRTVVMPIAREFSPDIVLVSAGFDAAEGhpPPLGGYKVSPA 300
HDAC10 cd11683
Histone deacetylase 10; Histone deacetylases 10 are class IIb Zn-dependent enzymes that ...
 61-337 1.71e-07

Histone deacetylase 10; Histone deacetylases 10 are class IIb Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. HDACs usually act via association with DNA binding proteins to target specific chromatin regions. HDAC10 has an N-terminal deacetylase domain and a C-terminal pseudo-repeat that shares significant similarity with its catalytic domain. It is located in the nucleus and cytoplasm, and is involved in regulation of melanogenesis. It transcriptionally down-regulates thioredoxin-interacting protein (TXNIP), leading to altered reactive oxygen species (ROS) signaling in human gastric cancer cells. Known interaction partners of HDAC10 are Pax3, KAP1, hsc70 and HDAC3 proteins.


Pssm-ID: 212546 [Multi-domain]  Cd Length: 337  Bit Score: 52.17  E-value: 1.71e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317  61 VEAREASEEDLLVVHTRRYLNELKWSFVV------ATITEIPPVIFLPNFLVQRKVLRPLRTQTGGTIMAGKlaVERGWA 134
Cdd:cd11683  33 LPAREASEEEILLVHSPEYLSLVRETQVMnkeelmAISGKYDAVYFHPNTFHCARLAAGATLQLVDAVLTGE--VQNGMA 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317 135 INVGGGfHHCSSDRGGGFCAYADITLAIKFLfERVEGISRATIIDLDAHQGNGHERDFMGDKRVYimdVYNRHIYPGDRF 214
Cdd:cd11683 111 LVRPPG-HHSQRNAANGFCVFNNVAIAAEYA-KKKYGLHRILIVDWDVHHGQGIQYIFEEDPSVL---YFSWHRYEHQRF 185

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450317 215 -------AKEAIRR------KVELEW---GTEDEEYLEKVERNVRRSLQEHLPDVVVYNAGTDVLEGDRLGGLSISPAgi 278
Cdd:cd11683 186 wpflresDYDAVGRgkglgfNINLPWnkvGMGNADYLAAFFHVLLPLAFEFDPELVLVSAGFDSAIGDPEGQMCATPE-- 263

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21450317 279 vkrdevvfrvVRAHDIPILM---------VTSGGYQKRTariIADSI-LNLHDL------GLIGPEFPCVSAQNS 337
Cdd:cd11683 264 ----------CFAHLTHLLMvlaggklcaVLEGGYHLES---LAESVcMTVQTLlgdplpRLSGEMTPCQSALES 325
HDAC_Hos3 cd09998
Class II histone deacetylases Hos3 and related proteins; Fungal histone deacetylase Hos3 from ...
 142-187 1.41e-04

Class II histone deacetylases Hos3 and related proteins; Fungal histone deacetylase Hos3 from Saccharomyces cerevisiae is a Zn-dependent enzyme belonging to HDAC class II. It catalyzes hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. Histone deacetylases usually act via association with DNA binding proteins to target specific chromatin regions. Hos3 deacetylase is homodimer, in vitro it shows specificity to H4, H3 and H2A.


Pssm-ID: 212522 [Multi-domain]  Cd Length: 353  Bit Score: 43.21  E-value: 1.41e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 21450317 142 HHCSSDRGGGFCAYADITLAIKFLFERvEGISRATIIDLDAHQGNG 187
Cdd:cd09998 120 HHCSESTPSGFCWVNNVHVGAAHAYLT-HGITRVVILDIDLHHGNG 164
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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